| Year |
Citation |
Score |
| 2024 |
Kallifidas D, Dhakal D, Chen M, Chen QY, Kokkaliari S, Colon Rosa NA, Ratnayake R, Bruner SD, Paul VJ, Ding Y, Luesch H. Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs. Organic Letters. PMID 38330916 DOI: 10.1021/acs.orglett.3c04083 |
0.462 |
|
| 2023 |
Tang Q, Ratnayake R, Seabra G, Jiang Z, Fang R, Cui L, Ding Y, Kahveci T, Bian J, Li C, Luesch H, Li Y. Morphological Profiling for Drug Discovery in the Era of Deep Learning. Arxiv. PMID 38168460 |
0.409 |
|
| 2023 |
Atanasova KR, Perkins CM, Ratnayake R, Jiang J, Chen QY, Schmittgen TD, Luesch H. Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids. Biorxiv : the Preprint Server For Biology. PMID 38077007 DOI: 10.1101/2023.11.27.567685 |
0.65 |
|
| 2023 |
Al-Awadhi FH, Simon EF, Liu N, Ratnayake R, Paul VJ, Luesch H. Discovery and Anti-Inflammatory Activity of a Cyanobacterial Fatty Acid Targeting the Keap1/Nrf2 Pathway. Marine Drugs. 21. PMID 37999377 DOI: 10.3390/md21110553 |
0.796 |
|
| 2023 |
Kokkaliari S, Luo D, Paul VJ, Luesch H. Isolation and Biological Activity of Iezoside and Iezoside B, SERCA Inhibitors from Floridian Marine Cyanobacteria. Marine Drugs. 21. PMID 37504909 DOI: 10.3390/md21070378 |
0.8 |
|
| 2023 |
Luo D, Ratnayake R, Atanasova KR, Paul VJ, Luesch H. Targeted and Functional Genomics Approaches to the Mechanism of Action of Lagunamide D, a Mitochondrial Cytotoxin from Marine Cyanobacteria. Biochemical Pharmacology. 115608. PMID 37201874 DOI: 10.1016/j.bcp.2023.115608 |
0.795 |
|
| 2023 |
Dhakal D, Kallifidas D, Chen M, Kokkaliari S, Chen QY, Paul VJ, Ding Y, Luesch H. Heterologous Production of the C33-C45 Polyketide Fragment of Anticancer Apratoxins in a Cyanobacterial Host. Organic Letters. PMID 36961224 DOI: 10.1021/acs.orglett.3c00462 |
0.787 |
|
| 2022 |
Dhakal D, Kokkaliari S, Rubin GM, Paul VJ, Ding Y, Luesch H. Biosynthesis of Lyngbyastatins 1 and 3, Cytotoxic Depsipeptides from an sp. Marine Cyanobacterium. Journal of Natural Products. PMID 36546857 DOI: 10.1021/acs.jnatprod.2c00782 |
0.751 |
|
| 2022 |
da Silva L, Jiang J, Perkins C, Atanasova KR, Bray JK, Bulut G, Azevedo-Pouly A, Campbell-Thompson M, Yang X, Hakimjavadi H, Chamala S, Ratnayake R, Gharaibeh RZ, Li C, Luesch H, et al. Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia. Cell Death Discovery. 8: 378. PMID 36055991 DOI: 10.1038/s41420-022-01165-4 |
0.668 |
|
| 2022 |
Pohl MO, Martin-Sancho L, Ratnayake R, White KM, Riva L, Chen QY, Lieber G, Busnadiego I, Yin X, Lin S, Pu Y, Pache L, Rosales R, Déjosez M, Qin Y, ... ... Luesch H, et al. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity. Acs Infectious Diseases. PMID 35766385 DOI: 10.1021/acsinfecdis.2c00008 |
0.782 |
|
| 2022 |
Atanasova KR, Chakraborty S, Ratnayake R, Khare KD, Luesch H, Lele TP. An epigenetic small molecule screen to target abnormal nuclear morphology in human cells. Molecular Biology of the Cell. mbcE21100528. PMID 35323046 DOI: 10.1091/mbc.E21-10-0528 |
0.693 |
|
| 2022 |
Gunasekera SP, Kokkaliari S, Ratnayake R, Sauvage T, Dos Santos LAH, Luesch H, Paul VJ. Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium sp. Collected from the Reefs of Fort Lauderdale, Florida. Molecules (Basel, Switzerland). 27. PMID 35268819 DOI: 10.3390/molecules27051717 |
0.699 |
|
| 2022 |
Brumley DA, Gunasekera SP, Sauvage T, Dos Santos LAH, Chen QY, Paul VJ, Luesch H. Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, sp. Journal of Natural Products. PMID 35167289 DOI: 10.1021/acs.jnatprod.1c01073 |
0.731 |
|
| 2021 |
Cai W, Ratnayake R, Wang M, Chen QY, Raisch KP, Dang LH, Law BK, Luesch H. Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm. Current Research in Pharmacology and Drug Discovery. 2: 100053. PMID 34909679 DOI: 10.1016/j.crphar.2021.100053 |
0.802 |
|
| 2021 |
Qiu B, Tan A, Tan YZ, Chen QY, Luesch H, Wang X. Largazole Inhibits Ocular Angiogenesis by Modulating the Expression of VEGFR2 and p21. Marine Drugs. 19. PMID 34436310 DOI: 10.3390/md19080471 |
0.674 |
|
| 2021 |
Dhakal D, Chen M, Luesch H, Ding Y. Heterologous production of cyanobacterial compounds. Journal of Industrial Microbiology & Biotechnology. PMID 33928376 DOI: 10.1093/jimb/kuab003 |
0.72 |
|
| 2021 |
Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, et al. A Modular Synthetic Route Involving -Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. Journal of Medicinal Chemistry. PMID 33881312 DOI: 10.1021/acs.jmedchem.1c00168 |
0.781 |
|
| 2021 |
Matthew S, Chen QY, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, Prota AE, Lim ST, Wang X, Díaz JF, Risinger AL, Paul VJ, Oliva MÁ, Luesch H. Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619102 DOI: 10.1073/pnas.2021847118 |
0.802 |
|
| 2021 |
Elsadek LA, Matthews JH, Nishimura S, Nakatani T, Ito A, Gu T, Luo D, Salvador-Reyes LA, Paul VJ, Kakeya H, Luesch H. Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A. Chembiochem : a European Journal of Chemical Biology. PMID 33527693 DOI: 10.1002/cbic.202000685 |
0.794 |
|
| 2021 |
Grenning AJ, Emmetiere F, Ratnayake R, Schares HAM, Jones KFM, Bevan-Smith E, Luesch H, Harki DA. Function-oriented and modular (+/-)-cis-pseudoguaianolide synthesis: Discovery of new Nrf2 Activators and NF-κB Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33502811 DOI: 10.1002/chem.202100038 |
0.677 |
|
| 2021 |
Liang X, Chen QY, Seabra GM, Matthew S, Kwan JC, Li C, Paul VJ, Luesch H. Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells. Journal of Natural Products. PMID 33480689 DOI: 10.1021/acs.jnatprod.0c01003 |
0.816 |
|
| 2020 |
Lizarme-Salas Y, Ariawan AD, Ratnayake R, Luesch H, Finch A, Hunter L. Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity. Beilstein Journal of Organic Chemistry. 16: 2663-2670. PMID 33178356 DOI: 10.3762/bjoc.16.216 |
0.694 |
|
| 2020 |
Chen QY, Luo D, Seabra GM, Luesch H. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorganic & Medicinal Chemistry. 28: 115756. PMID 33002682 DOI: 10.1016/J.Bmc.2020.115756 |
0.813 |
|
| 2020 |
Nasser AA, Eissa IH, Oun MR, El-Zahabi MA, Taghour MS, Belal A, Saleh AM, Mehany ABM, Luesch H, Mostafa AE, Afifi WM, Rocca JR, Mahdy HA. Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR and EGFR. Organic & Biomolecular Chemistry. PMID 32959865 DOI: 10.1039/D0Ob01557A |
0.411 |
|
| 2020 |
Jiang G, Zhang P, Ratnayake R, Yang G, Zhang Y, Zuo R, Powell M, Huguet-Tapia JC, Abboud KA, Dang LH, Teplitski M, Paul V, Xiao R, Zaman KAU, Hu Z, ... ... Luesch H, et al. Fungal epithiodiketopiperazines carrying α,β-polysulfide bridges from Penecillium steckii YE, and their chemical interconversion. Chembiochem : a European Journal of Chemical Biology. PMID 32816319 DOI: 10.1002/Cbic.202000403 |
0.755 |
|
| 2020 |
Paciaroni NG, Norwood VM, Ratnayake R, Luesch H, Huigens RW. Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorganic & Medicinal Chemistry. 28: 115546. PMID 32616180 DOI: 10.1016/J.Bmc.2020.115546 |
0.726 |
|
| 2020 |
Al-Awadhi FH, Salvador-Reyes LA, Elsadek LA, Ratnayake R, Chen QY, Luesch H. Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases. Acs Chemical Neuroscience. PMID 32559056 DOI: 10.1021/Acschemneuro.0C00093 |
0.784 |
|
| 2020 |
Al-Awadhi FH, Luesch H. Targeting eukaryotic proteases for natural products-based drug development. Natural Product Reports. 37: 827-860. PMID 32519686 DOI: 10.1039/C9Np00060G |
0.805 |
|
| 2020 |
Brumley DA, Gunasekera SP, Chen QY, Paul VJ, Luesch H. Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore. Organic Letters. PMID 32418432 DOI: 10.1021/Acs.Orglett.0C01281 |
0.733 |
|
| 2020 |
Tamashunas AC, Tocco VJ, Matthews J, Zhang Q, Atanasova KR, Paschall L, Pathak S, Ratnayake R, Stephens AD, Luesch H, Licht JD, Lele TP. High-throughput gene screen reveals modulators of nuclear shape. Molecular Biology of the Cell. mbcE19090520. PMID 32320319 DOI: 10.1091/Mbc.E19-09-0520 |
0.773 |
|
| 2020 |
Luo D, Luesch H. Ahp-Cyclodepsipeptide Inhibitors of Elastase: Lyngbyastatin 7 Stability, Scalable Synthesis, and Focused Library Analysis. Acs Medicinal Chemistry Letters. 11: 419-425. PMID 32292544 DOI: 10.1021/Acsmedchemlett.9B00473 |
0.802 |
|
| 2020 |
Ratnayake R, Gunasekera SP, Ma JJ, Dang LH, Carney T, Paul VJ, Luesch H. Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. Chembiochem : a European Journal of Chemical Biology. PMID 32237262 DOI: 10.1002/Cbic.202000180 |
0.705 |
|
| 2020 |
Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. Tutuilamides A-C: Vinyl-Chloride Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. Acs Chemical Biology. PMID 31935054 DOI: 10.2210/Pdb6Th7/Pdb |
0.808 |
|
| 2020 |
Norwood VM, Brice-Tutt A, Eans SO, Stacy H, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens Iii RW. Preventing Morphine Seeking Behavior through the Re-engineering of Vincamine's Biological Activity. Journal of Medicinal Chemistry. PMID 31913038 DOI: 10.1021/Acs.Jmedchem.9B01924 |
0.674 |
|
| 2020 |
Norwood V, Brice-Tutt AC, Eans SO, Stacy HM, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens RW. Preventing Morphine-SeekingBehavior through the Re-Engineeringof Vincamine’s Biological Activity Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B01924.S001 |
0.674 |
|
| 2020 |
Liu Q, Liu L, Ratnayake R, Luesch H, Guo Y, Ye T. Nine‐Step Total Synthesis and Biological Evaluation of Rhizonin A Chinese Journal of Chemistry. DOI: 10.1002/Cjoc.202000222 |
0.667 |
|
| 2019 |
Liu L, Guo Y, Liu Q, Ratnayake R, Luesch H, Ye T. Total Synthesis of Endolides A and B. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 2279-2284. PMID 34163101 DOI: 10.1055/s-0037-1610736 |
0.648 |
|
| 2019 |
Bousquet MS, Ratnayake R, Pope JL, Chen QY, Zhu F, Chen S, Carney TJ, Gharaibeh RZ, Jobin C, Paul VJ, Luesch H. Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. Free Radical Biology & Medicine. PMID 31536771 DOI: 10.1016/J.Freeradbiomed.2019.09.013 |
0.785 |
|
| 2019 |
Liang X, Matthew S, Chen QY, Kwan JC, Paul VJ, Luesch H. Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium. Organic Letters. PMID 31414826 DOI: 10.1021/Acs.Orglett.9B02525 |
0.805 |
|
| 2019 |
Qiu B, Tan A, Veluchamy AB, Li Y, Murray H, Cheng W, Liu C, Busoy JM, Chen QY, Sistla S, Hunziker W, Cheung CMG, Wong TY, Hong W, Luesch H, et al. Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases. Investigative Ophthalmology & Visual Science. 60: 3254-3263. PMID 31361305 DOI: 10.1167/Iovs.19-26936 |
0.678 |
|
| 2019 |
Liang X, Luo D, Luesch H. Advances in Exploring the Therapeutic Potential of Marine Natural Products. Pharmacological Research. 104373. PMID 31351913 DOI: 10.1016/J.Phrs.2019.104373 |
0.802 |
|
| 2019 |
Linington RG, Kubanek J, Luesch H. New methods for isolation and structure determination of natural products. Natural Product Reports. PMID 31250867 DOI: 10.1039/C9Np90023C |
0.326 |
|
| 2019 |
Liang X, Luo D, Yan JL, Rezaei MA, Salvador-Reyes LA, Gunasekera SP, Li C, Ye T, Paul VJ, Luesch H. Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria. Organic Letters. PMID 30779584 DOI: 10.1021/Acs.Orglett.9B00163 |
0.804 |
|
| 2019 |
Luo D, Putra MY, Ye T, Paul VJ, Luesch H. Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria. Marine Drugs. 17. PMID 30717076 DOI: 10.3390/Md17020083 |
0.795 |
|
| 2019 |
Gunasekera SP, Meyer JL, Ding Y, Abboud KA, Luo D, Campbell JE, Angerhofer A, Goodsell JL, Raymundo LJ, Liu J, Ye T, Luesch H, Teplitski M, Paul VJ. Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles. Journal of Natural Products. PMID 30636420 DOI: 10.1021/Acs.Jnatprod.8B00804 |
0.79 |
|
| 2019 |
Liu L, Guo Y, Liu Q, Ratnayake R, Luesch H, Ye T. Total Synthesis of Endolides A and B Synlett. 30: 2279-2284. DOI: 10.1055/S-0037-1610736 |
0.675 |
|
| 2018 |
Chen QY, Chaturvedi PR, Luesch H. Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor. Organic Process Research & Development. 22: 190-199. PMID 37332527 DOI: 10.1021/acs.oprd.7b00352 |
0.683 |
|
| 2018 |
Brumley D, Spencer KA, Gunasekera SP, Sauvage T, Biggs J, Paul VJ, Luesch H. Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales). Journal of Natural Products. PMID 30489078 DOI: 10.1021/Acs.Jnatprod.8B00650 |
0.809 |
|
| 2018 |
Yan JL, Cheng Y, Chen J, Ratnayake R, Dang LH, Luesch H, Guo Y, Ye T. Total Synthesis of Asperphenins A and B. Organic Letters. PMID 30232896 DOI: 10.1021/Acs.Orglett.8B02652 |
0.665 |
|
| 2018 |
Cai W, Ratnayake R, Gerber MH, Chen QY, Yu Y, Derendorf H, Trevino JG, Luesch H. Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model. Investigational New Drugs. PMID 30073464 DOI: 10.1007/S10637-018-0647-0 |
0.797 |
|
| 2018 |
Al-Awadhi FH, Gao B, Rezaei MA, Kwan JC, Li C, Ye T, Paul VJ, Luesch H. Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium. Journal of Medicinal Chemistry. PMID 30015488 DOI: 10.1021/Acs.Jmedchem.8B00885 |
0.826 |
|
| 2018 |
Garrison AT, Abouelhassan Y, Kallifidas D, Tan H, Kim YS, Jin S, Luesch H, Huigens Iii RW. An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication and Prodrug Exploration. Journal of Medicinal Chemistry. PMID 29638121 DOI: 10.1021/Acs.Jmedchem.7B01903 |
0.764 |
|
| 2018 |
Cai W, Matthew S, Chen QY, Paul VJ, Luesch H. Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. Bioorganic & Medicinal Chemistry. PMID 29606488 DOI: 10.1016/J.Bmc.2018.03.022 |
0.81 |
|
| 2018 |
Jiang G, Zhang Y, Powell MM, Zhang P, Zuo R, Zhang Y, Kallifidas D, Tieu AM, Luesch H, Loria R, Ding Y. High-yield production of herbicidal thaxtomins and analogs in a nonpathogenicstrain. Applied and Environmental Microbiology. PMID 29602787 DOI: 10.1128/Aem.00164-18 |
0.797 |
|
| 2018 |
Matthews JH, Liang X, Paul VJ, Luesch H. A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance. Acs Chemical Biology. PMID 29565554 DOI: 10.1021/Acschembio.7B01025 |
0.737 |
|
| 2018 |
Kallifidas D, Jiang G, Ding Y, Luesch H. Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters. Microbial Cell Factories. 17: 25. PMID 29454348 DOI: 10.1186/S12934-018-0874-2 |
0.775 |
|
| 2018 |
Al-Awadhi FH, Paul VJ, Luesch H. Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer. Chembiochem : a European Journal of Chemical Biology. PMID 29405541 DOI: 10.1002/Cbic.201700627 |
0.807 |
|
| 2018 |
Yang G, Cozad MA, Holland DA, Zhang Y, Luesch H, Ding Y. Photosynthetic production of sunscreen shinorine using an engineered cyanobacterium. Acs Synthetic Biology. PMID 29304277 DOI: 10.1021/Acssynbio.7B00397 |
0.536 |
|
| 2018 |
Chen Q, Chaturvedi PR, Luesch H. Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor Organic Process Research & Development. 22: 190-199. DOI: 10.1021/Acs.Oprd.7B00352 |
0.708 |
|
| 2018 |
Al-Awadhi FH, Paul VJ, Luesch H. Cover Feature: Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer (ChemBioChem 8/2018) Chembiochem. 19: 765-765. DOI: 10.1002/Cbic.201800138 |
0.789 |
|
| 2017 |
Cai W, Chen QY, Dang LH, Luesch H. Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors". Acs Medicinal Chemistry Letters. 8: 1342. PMID 29266134 DOI: 10.1021/Acsmedchemlett.7B00498 |
0.763 |
|
| 2017 |
Matthew S, Schupp PJ, Luesch H. Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii. Journal of Natural Products. PMID 29257686 DOI: 10.1021/Acs.Jnatprod.7B00982 |
0.623 |
|
| 2017 |
Cai W, Salvador-Reyes LA, Zhang W, Chen QY, Matthew S, Ratnayake R, Seo SJ, Dolles S, Gibson DJ, Paul VJ, Luesch H. Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. Acs Chemical Biology. PMID 29205032 DOI: 10.1021/Acschembio.7B00827 |
0.787 |
|
| 2017 |
Al-Awadhi FH, Law BK, Paul VJ, Luesch H. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. Journal of Natural Products. PMID 29087712 DOI: 10.1021/Acs.Jnatprod.7B00551 |
0.798 |
|
| 2017 |
Cai W, Chen QY, Dang LH, Luesch H. Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors. Acs Medicinal Chemistry Letters. 8: 1007-1012. PMID 29057042 DOI: 10.1021/Acsmedchemlett.7B00192 |
0.772 |
|
| 2017 |
Alfurhood JA, Sun H, Kabb CP, Tucker BS, Matthews JH, Luesch H, Sumerlin BS. Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers. Polymer Chemistry. 8: 4983-4987. PMID 28959359 DOI: 10.1039/C7Py00196G |
0.624 |
|
| 2017 |
Yang G, Zhang Y, Lee NK, Cozad MA, Kearney SE, Luesch H, Ding Y. Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways. Scientific Reports. 7: 11888. PMID 28928426 DOI: 10.1038/S41598-017-12244-3 |
0.546 |
|
| 2017 |
Al-Awadhi FH, Salvador LA, Law BK, Paul VJ, Luesch H. Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer. Marine Drugs. 15. PMID 28926939 DOI: 10.3390/Md15090290 |
0.805 |
|
| 2017 |
Tocco VJ, Li Y, Christopher KG, Matthews JH, Aggarwal V, Paschall L, Luesch H, Licht JD, Dickinson RB, Lele TP. The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells. Journal of Cellular Physiology. PMID 28542912 DOI: 10.1002/Jcp.26031 |
0.629 |
|
| 2017 |
Yang H, Abouelhassan Y, Burch GM, Kallifidas D, Huang G, Yousaf H, Jin S, Luesch H, Huigens RW. A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis. Scientific Reports. 7: 2003. PMID 28515440 DOI: 10.1038/S41598-017-01045-3 |
0.777 |
|
| 2017 |
Kim B, Ratnayake R, Lee H, Shi G, Zeller SL, Li C, Luesch H, Hong J. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorganic & Medicinal Chemistry. PMID 28416100 DOI: 10.1016/J.Bmc.2017.03.071 |
0.765 |
|
| 2017 |
Luesch H. I8 Marine natural products as starting points for drug discovery and development Biochemical Pharmacology. 139: 106-107. DOI: 10.1016/J.Bcp.2017.06.054 |
0.348 |
|
| 2017 |
Paciaroni NG, Ratnayake R, Matthews JH, Norwood VM, Arnold AC, Dang LH, Luesch H, Huigens RW. Back Cover: A Tryptoline Ring‐Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine (Chem. Eur. J. 18/2017) Chemistry: a European Journal. 23: 4463-4463. DOI: 10.1002/Chem.201605731 |
0.777 |
|
| 2016 |
Paciaroni N, Ratnayake R, Matthews J, Norwood V, Arnold A, Dang L, Luesch H, Huigens Iii RW. A Tryptoline Ring Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27900785 DOI: 10.1002/Chem.201604795 |
0.811 |
|
| 2016 |
Wu P, Cai W, Chen QY, Xu S, Yin R, Li Y, Zhang W, Luesch H. Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product. Organic Letters. PMID 27723359 DOI: 10.1021/Acs.Orglett.6B02780 |
0.769 |
|
| 2016 |
Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H. Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata. Journal of Natural Products. PMID 27380142 DOI: 10.1021/Acs.Jnatprod.6B00203 |
0.791 |
|
| 2016 |
Al-Awadhi FH, Ratnayake R, Paul VJ, Luesch H. Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium. Bioorganic & Medicinal Chemistry. PMID 27211244 DOI: 10.1016/J.Bmc.2016.04.062 |
0.814 |
|
| 2016 |
Gunasekera SP, Li Y, Ratnayake R, Luo D, Lo J, Reibenspies JH, Xu Z, Clare-Salzler MJ, Ye T, Paul VJ, Luesch H. Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27139508 DOI: 10.1002/Chem.201600674 |
0.816 |
|
| 2016 |
Cai W, Matthews JH, Paul VJ, Luesch H. Pitiamides A and B, Multifunctional Fatty Acid Amides from Marine Cyanobacteria. Planta Medica. PMID 27135625 DOI: 10.1055/S-0042-105157 |
0.763 |
|
| 2016 |
Garrison AT, Abouelhassan Y, Norwood VM, Kallifidas D, Bai F, Nguyen MT, Rolfe M, Burch GM, Jin S, Luesch H, Huigens Iii RW. Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines that Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 27018907 DOI: 10.1021/Acs.Jmedchem.5B02004 |
0.768 |
|
| 2016 |
Bousquet MS, Ma JJ, Ratnayake R, Havre PA, Yao J, Dang NH, Paul VJ, Carney TJ, Dang LH, Luesch H. Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer. Acs Chemical Biology. PMID 26938486 DOI: 10.1021/Acschembio.5B00860 |
0.783 |
|
| 2016 |
Salvador LA, Paul VJ, Luesch H. Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida. Journal of Natural Products. PMID 26885760 DOI: 10.1021/Acs.Jnatprod.6B00120 |
0.762 |
|
| 2015 |
Luo D, Chen QY, Luesch H. Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases. The Journal of Organic Chemistry. PMID 26709602 DOI: 10.1021/Acs.Joc.5B02386 |
0.827 |
|
| 2015 |
Garrison AT, Abouelhassan Y, Kallifidas D, Bai F, Ukhanova M, Mai V, Jin S, Luesch H, Huigens RW. Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis. Angewandte Chemie (International Ed. in English). PMID 26480852 DOI: 10.1002/Anie.201508155 |
0.748 |
|
| 2015 |
Engene N, Tronholm A, Salvador-Reyes LA, Luesch H, Paul VJ. Caldora penicillata gen. nov., comb. nov. (Cyanobacteria), a pantropical marine species with biomedical relevance. Journal of Phycology. 51: 670-681. PMID 26327714 DOI: 10.1111/Jpy.12309 |
0.307 |
|
| 2015 |
Salvador-Reyes LA, Sneed J, Paul VJ, Luesch H. Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. Journal of Natural Products. PMID 26204500 DOI: 10.1021/Acs.Jnatprod.5B00293 |
0.387 |
|
| 2015 |
Luo D, Luesch H. A dive into membrane dynamics with sponge peptides. Chemistry & Biology. 22: 565-7. PMID 26000744 DOI: 10.1016/J.Chembiol.2015.05.003 |
0.746 |
|
| 2015 |
Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Luesch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, Choe K. Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. Acs Chemical Biology. 10: 1871-9. PMID 25946346 DOI: 10.1021/Acschembio.5B00304 |
0.809 |
|
| 2015 |
Salvador-Reyes LA, Engene N, Paul VJ, Luesch H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. Journal of Natural Products. 78: 486-92. PMID 25635943 DOI: 10.1021/Np500931Q |
0.407 |
|
| 2015 |
Salvador-Reyes LA, Luesch H. Biological targets and mechanisms of action of natural products from marine cyanobacteria. Natural Product Reports. 32: 478-503. PMID 25571978 DOI: 10.1039/C4Np00104D |
0.423 |
|
| 2015 |
Al-Awadhi F, Paul V, Luesch H. Isolation, structure elucidation and biological evaluation of novel cathepsin inhibitors from marine cyanobacteria Planta Medica. 81. DOI: 10.1055/S-0035-1556352 |
0.802 |
|
| 2015 |
Cai W, Salvador-Reyes L, Zhang W, Matthew S, Ratnayake R, Paul V, Dang L, Luesch H. Discovery, synthesis, and biological evaluation of apratyramide, a marine-derived transcriptional stimulator of VEGF-A Planta Medica. 81. DOI: 10.1055/S-0035-1556169 |
0.783 |
|
| 2014 |
Salvador LA, Park H, Al-Awadhi FH, Liu Y, Kim B, Zeller SL, Chen QY, Hong J, Luesch H. Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. Acs Medicinal Chemistry Letters. 5: 905-10. PMID 25147612 DOI: 10.1021/Ml500170R |
0.811 |
|
| 2014 |
Kim B, Park H, Salvador LA, Serrano PE, Kwan JC, Zeller SL, Chen QY, Ryu S, Liu Y, Byeon S, Luesch H, Hong J. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorganic & Medicinal Chemistry Letters. 24: 3728-31. PMID 25070421 DOI: 10.1016/J.Bmcl.2014.07.006 |
0.798 |
|
| 2014 |
Chen QY, Liu Y, Cai W, Luesch H. Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity. Journal of Medicinal Chemistry. 57: 3011-29. PMID 24660812 DOI: 10.1021/Jm4019965 |
0.812 |
|
| 2014 |
Yu M, Salvador LA, Sy SK, Tang Y, Singh RS, Chen QY, Liu Y, Hong J, Derendorf H, Luesch H. Largazole pharmacokinetics in rats by LC-MS/MS. Marine Drugs. 12: 1623-40. PMID 24658499 DOI: 10.3390/Md12031623 |
0.762 |
|
| 2014 |
Kwan JC, Liu Y, Ratnayake R, Hatano R, Kuribara A, Morimoto C, Ohnuma K, Paul VJ, Ye T, Luesch H. Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Chembiochem : a European Journal of Chemical Biology. 15: 799-804. PMID 24591193 DOI: 10.1002/Cbic.201300762 |
0.818 |
|
| 2014 |
Chen Q, Liu Y, Cai W, Luesch H. Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with enhanced activity Planta Medica. 80. DOI: 10.1055/S-0034-1382377 |
0.629 |
|
| 2013 |
Ratnayake R, Liu Y, Paul VJ, Luesch H. Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system. Cancer Prevention Research (Philadelphia, Pa.). 6: 989-99. PMID 24005795 DOI: 10.1158/1940-6207.Capr-13-0014 |
0.747 |
|
| 2013 |
Montaser R, Paul VJ, Luesch H. Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Organic Letters. 15: 4050-3. PMID 23915229 DOI: 10.1055/S-0033-1348539 |
0.804 |
|
| 2013 |
Wang R, Mason DE, Choe KP, Lewin AS, Peters EC, Luesch H. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway Acs Chemical Biology. 8: 1764-1774. PMID 23773140 DOI: 10.1021/Cb4000103 |
0.407 |
|
| 2013 |
Liu H, Liu Y, Wang Z, Xing X, Maguire AR, Luesch H, Zhang H, Xu Z, Ye T. Total synthesis and biological evaluation of grassypeptolide A. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 6774-84. PMID 23536467 DOI: 10.1002/Chem.201203667 |
0.541 |
|
| 2013 |
Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. Journal of Medicinal Chemistry. 56: 1276-90. PMID 23350733 DOI: 10.1021/Jm3017305 |
0.814 |
|
| 2013 |
Wang R, Paul VJ, Luesch H. Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radical Biology & Medicine. 57: 141-53. PMID 23291594 DOI: 10.1016/J.Freeradbiomed.2012.12.019 |
0.467 |
|
| 2013 |
Gupta E, Santos N, Liu Y, Havre P, Dang NH, Luesch H, Dang LH. Targeting HIF-1α and HIF-2α to Overcome Treatment Resistance Mediated by Oncogenic KRAS in Colorectal Cancer Journal of Cancer Therapy. 4: 1132-1139. DOI: 10.4236/Jct.2013.46129 |
0.546 |
|
| 2012 |
Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of Medicinal Chemistry. 55: 10749-65. PMID 23181502 DOI: 10.1021/Jm301630S |
0.827 |
|
| 2012 |
Montaser R, Paul VJ, Luesch H. Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Chembiochem : a European Journal of Chemical Biology. 13: 2676-81. PMID 23143757 DOI: 10.1002/Cbic.201200502 |
0.783 |
|
| 2012 |
Yang S, Zhang W, Ding N, Lo J, Liu Y, Clare-Salzler MJ, Luesch H, Li Y. Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorganic & Medicinal Chemistry. 20: 4774-80. PMID 22748705 DOI: 10.1016/J.Bmc.2012.05.077 |
0.538 |
|
| 2012 |
Salvador LA, Luesch H. Discovery and mechanism of natural products as modulators of histone acetylation. Current Drug Targets. 13: 1029-47. PMID 22594471 DOI: 10.2174/138945012802008973 |
0.802 |
|
| 2012 |
Hong J, Luesch H. Largazole: from discovery to broad-spectrum therapy. Natural Product Reports. 29: 449-56. PMID 22334030 DOI: 10.1039/C2Np00066K |
0.627 |
|
| 2012 |
Montaser R, Paul V, Luesch H. Chemistry and biology of novel cyanobacterial secondary metabolites from Guam Planta Medica. 78. DOI: 10.1055/S-0032-1320703 |
0.785 |
|
| 2012 |
Salvador L, Taori K, Ostrov D, Biggs J, Paul V, Luesch H. Novel elastase inhibitors from marine cyanobacteria: Structural diversity, target-bound crystal structures and cellular effects Planta Medica. 78. DOI: 10.1055/S-0032-1320292 |
0.789 |
|
| 2011 |
Santos N, Wenger JB, Havre P, Liu Y, Dagan R, Imanirad I, Ivey AM, Zlotecki RA, Algood CB, Gilbert SM, Allegra CJ, Okunieff P, Vieweg J, Dang NH, Luesch H, et al. Combination therapy for renal cell cancer: What are possible options? Oncology. 81: 220-229. PMID 22085914 DOI: 10.1159/000333470 |
0.518 |
|
| 2011 |
Chen QY, Liu Y, Luesch H. Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity. Acs Medicinal Chemistry Letters. 2: 861-865. PMID 22081789 DOI: 10.1021/Ml200176M |
0.789 |
|
| 2011 |
Wenger JB, Santos N, Liu Y, Dallas J, Subbiah S, Hochwald S, Huang EH, Dang DT, Allegra CJ, Luesch H, Dang LH. Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? Oncology Reviews. 5: 177-184. PMID 21949574 DOI: 10.1007/S12156-011-0082-3 |
0.482 |
|
| 2011 |
Montaser R, Luesch H. Marine natural products: a new wave of drugs? Future Medicinal Chemistry. 3: 1475-89. PMID 21882941 DOI: 10.4155/Fmc.11.118 |
0.794 |
|
| 2011 |
Montaser R, Paul VJ, Luesch H. Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry. 72: 2068-74. PMID 21843895 DOI: 10.1016/J.Phytochem.2011.07.014 |
0.812 |
|
| 2011 |
Meickle T, Gunasekera SP, Liu Y, Luesch H, Paul VJ. Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. Bioorganic & Medicinal Chemistry. 19: 6576-80. PMID 21705224 DOI: 10.1016/J.Bmc.2011.05.051 |
0.579 |
|
| 2011 |
Lee SU, Kwak HB, Pi SH, You HK, Byeon SR, Ying Y, Luesch H, Hong J, Kim SH. In Vitro and In Vivo Osteogenic Activity of Largazole. Acs Medicinal Chemistry Letters. 2: 248-251. PMID 21666868 DOI: 10.1021/Ml1002794 |
0.52 |
|
| 2011 |
Salvador LA, Biggs JS, Paul VJ, Luesch H. Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. Journal of Natural Products. 74: 917-27. PMID 21446699 DOI: 10.1021/Np200076T |
0.81 |
|
| 2011 |
Gunasekera SP, Owle CS, Montaser R, Luesch H, Paul VJ. Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. Journal of Natural Products. 74: 871-6. PMID 21341718 DOI: 10.1021/Np1008015 |
0.807 |
|
| 2011 |
Kwan JC, Meickle T, Ladwa D, Teplitski M, Paul V, Luesch H. Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa Molecular Biosystems. 7: 1205-1216. PMID 21258753 DOI: 10.1039/C0Mb00180E |
0.69 |
|
| 2011 |
Montaser R, Abboud KA, Paul VJ, Luesch H. Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. Journal of Natural Products. 74: 109-12. PMID 21138309 DOI: 10.1021/Np1006839 |
0.804 |
|
| 2011 |
Akindele AJ, Eksioglu EA, Kwan JC, Adeyemi OO, Liu C, Luesch H, James MO. Biological effects of Byrsocarpus coccineus in vitro. Pharmaceutical Biology. 49: 152-60. PMID 21110733 DOI: 10.3109/13880209.2010.504967 |
0.647 |
|
| 2011 |
Wenger JB, Chun SY, Dang DT, Luesch H, Dang LH. Combination therapy targeting cancer metabolism Medical Hypotheses. 76: 169-172. PMID 20947261 DOI: 10.1016/J.Mehy.2010.09.008 |
0.328 |
|
| 2010 |
Kwan JC, Ratnayake R, Abboud KA, Paul VJ, Luesch H. Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. The Journal of Organic Chemistry. 75: 8012-23. PMID 21047144 DOI: 10.1021/Jo1013564 |
0.808 |
|
| 2010 |
Kwan JC, Luesch H. Weapons in disguise-Activating mechanisms and protecting group chemistry in nature Chemistry - a European Journal. 16: 13020-13029. PMID 20931575 DOI: 10.1002/Chem.201001562 |
0.698 |
|
| 2010 |
Salvador LA, Paul VJ, Luesch H. Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. Journal of Natural Products. 73: 1606-9. PMID 20806908 DOI: 10.1021/Np100467D |
0.79 |
|
| 2010 |
Liu Y, Salvador LA, Byeon S, Ying Y, Kwan JC, Law BK, Hong J, Luesch H. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 335: 351-61. PMID 20739454 DOI: 10.1124/Jpet.110.172387 |
0.818 |
|
| 2010 |
Matthew S, Salvador LA, Schupp PJ, Paul VJ, Luesch H. Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. Journal of Natural Products. 73: 1544-52. PMID 20704304 DOI: 10.1021/Np1004032 |
0.813 |
|
| 2010 |
Matthew S, Ratnayake R, Becerro MA, Ritson-Williams R, Paul VJ, Luesch H. Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Marine Drugs. 8: 1803-16. PMID 20631871 DOI: 10.3390/Md8061803 |
0.811 |
|
| 2010 |
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology. 12: 758-67. PMID 20622870 DOI: 10.1038/Ncb2080 |
0.448 |
|
| 2010 |
Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chemistry & Biology. 17: 537-47. PMID 20534351 DOI: 10.1016/J.Chembiol.2010.03.013 |
0.592 |
|
| 2010 |
Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H. Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 73: 463-6. PMID 20166701 DOI: 10.1021/Np900614N |
0.702 |
|
| 2010 |
Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ. Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. Journal of Natural Products. 73: 459-62. PMID 20020755 DOI: 10.1021/Np900603F |
0.719 |
|
| 2009 |
Luesch H, Abreu P. A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale cDNA library screening. Methods in Molecular Biology (Clifton, N.J.). 572: 261-77. PMID 20694698 DOI: 10.1007/978-1-60761-244-5_17 |
0.363 |
|
| 2009 |
Kwan JC, Taori K, Paul VJ, Luesch H. Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena. Marine Drugs. 7: 528-38. PMID 20098596 DOI: 10.3390/Md7040528 |
0.807 |
|
| 2009 |
Matthew S, Paul VJ, Luesch H. Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides. Phytochemistry. 70: 2058-63. PMID 19815244 DOI: 10.1016/J.Phytochem.2009.09.010 |
0.699 |
|
| 2009 |
Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. Journal of Medicinal Chemistry. 52: 5732-47. PMID 19715320 DOI: 10.1021/Jm9009394 |
0.717 |
|
| 2009 |
Taori K, Liu Y, Paul VJ, Luesch H. Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem : a European Journal of Chemical Biology. 10: 1634-9. PMID 19514039 DOI: 10.1002/Cbic.200900192 |
0.813 |
|
| 2009 |
Schriner SE, Avanesian A, Liu Y, Luesch H, Jafari M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radical Biology & Medicine. 47: 577-84. PMID 19486939 DOI: 10.1016/J.Freeradbiomed.2009.05.025 |
0.497 |
|
| 2009 |
Wang R, Kern JT, Goodfriend TL, Ball DL, Luesch H. Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 81: 53-9. PMID 19481916 DOI: 10.1016/J.Plefa.2009.04.008 |
0.372 |
|
| 2009 |
Meickle T, Matthew S, Ross C, Luesch H, Paul V. Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa. Planta Medica. 75: 1427-30. PMID 19431099 DOI: 10.1055/S-0029-1185675 |
0.696 |
|
| 2009 |
Liu Y, Law BK, Luesch H. Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Molecular Pharmacology. 76: 91-104. PMID 19403701 DOI: 10.1124/Mol.109.056085 |
0.562 |
|
| 2009 |
Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ. Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Applied and Environmental Microbiology. 75: 2879-88. PMID 19270119 DOI: 10.1128/Aem.02656-08 |
0.66 |
|
| 2009 |
Matthew S, Paul VJ, Luesch H. Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Medica. 75: 528-33. PMID 19214948 DOI: 10.1055/S-0029-1185332 |
0.713 |
|
| 2008 |
Luesch H, Liu Y. Genome-wide overexpression screen for activators of antioxidant gene transcription. Methods in Molecular Biology (Clifton, N.J.). 477: 343-54. PMID 19082959 DOI: 10.1007/978-1-60327-517-0_26 |
0.514 |
|
| 2008 |
Ying Y, Liu Y, Byeon SR, Kim H, Luesch H, Hong J. Synthesis and activity of largazole analogues with linker and macrocycle modification. Organic Letters. 10: 4021-4. PMID 18707106 DOI: 10.1021/Ol801532S |
0.681 |
|
| 2008 |
Taori K, Paul VJ, Luesch H. Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. Journal of Natural Products. 71: 1625-9. PMID 18693761 DOI: 10.1021/Np8002172 |
0.808 |
|
| 2008 |
Ying Y, Taori K, Kim H, Hong J, Luesch H. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 8455-9. PMID 18507379 DOI: 10.1021/Ja8013727 |
0.813 |
|
| 2008 |
Matthew S, Schupp PJ, Luesch H. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. Journal of Natural Products. 71: 1113-6. PMID 18461997 DOI: 10.1021/Np700717S |
0.68 |
|
| 2008 |
Gunasekera SP, Ross C, Paul VJ, Matthew S, Luesch H. Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa. Journal of Natural Products. 71: 887-90. PMID 18393465 DOI: 10.1021/Np0706769 |
0.67 |
|
| 2008 |
Kwan JC, Rocca JR, Abboud KA, Paul VJ, Luesch H. Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. Organic Letters. 10: 789-92. PMID 18220404 DOI: 10.1021/Ol702946D |
0.693 |
|
| 2008 |
Taori K, Paul VJ, Luesch H. Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. Journal of the American Chemical Society. 130: 1806-7. PMID 18205365 DOI: 10.1021/Ja7110064 |
0.826 |
|
| 2008 |
Matthew S, Ross C, Paul VJ, Luesch H. Serine protease inhibitors from the Floridian marine cyanobacterium Lyngbya confervoides Planta Medica. 74. DOI: 10.1055/S-0028-1084380 |
0.659 |
|
| 2008 |
Luesch H, Liu Y, Taori K, Kwan J, Matthew S, Paul V. Bioactive natural products from marine cyanobacteria: new structures and modes of action Planta Medica. 74. DOI: 10.1055/S-0028-1083977 |
0.782 |
|
| 2008 |
Matthew S, Ross C, Paul VJ, Luesch H. Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides Tetrahedron. 64: 4081-4089. DOI: 10.1016/J.Tet.2008.02.035 |
0.696 |
|
| 2007 |
Taori K, Matthew S, Rocca JR, Paul VJ, Luesch H. Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. Journal of Natural Products. 70: 1593-600. PMID 17910513 DOI: 10.1021/Np0702436 |
0.818 |
|
| 2007 |
Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H. A genomic screen for activators of the antioxidant response element. Proceedings of the National Academy of Sciences of the United States of America. 104: 5205-10. PMID 17360324 DOI: 10.1073/Pnas.0700898104 |
0.628 |
|
| 2007 |
Matthew S, Ross C, Rocca JR, Paul VJ, Luesch H. Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Journal of Natural Products. 70: 124-7. PMID 17253864 DOI: 10.1021/Np060471K |
0.702 |
|
| 2006 |
Luesch H. Towards high-throughput characterization of small molecule mechanisms of action. Molecular Biosystems. 2: 609-20. PMID 17216042 DOI: 10.1039/B609384A |
0.304 |
|
| 2006 |
Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG. A functional genomics approach to the mode of action of apratoxin A. Nature Chemical Biology. 2: 158-67. PMID 16474387 DOI: 10.1038/Nchembio769 |
0.498 |
|
| 2005 |
Luesch H, Wu TY, Ren P, Gray NS, Schultz PG, Supek F. A genome-wide overexpression screen in yeast for small-molecule target identification. Chemistry & Biology. 12: 55-63. PMID 15664515 DOI: 10.1016/J.Chembiol.2004.10.015 |
0.677 |
|
| 2003 |
Williams PG, Luesch H, Yoshida WY, Moore RE, Paul VJ. Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. Journal of Natural Products. 66: 595-8. PMID 12762789 DOI: 10.1021/Np030011G |
0.49 |
|
| 2003 |
Mooberry SL, Leal RM, Tinley TL, Luesch H, Moore RE, Corbett TH. The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. International Journal of Cancer. Journal International Du Cancer. 104: 512-21. PMID 12584751 DOI: 10.1002/Ijc.10982 |
0.486 |
|
| 2003 |
Luesch H, Hoffmann D, Hevel JM, Becker JE, Golakoti T, Moore RE. Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities. The Journal of Organic Chemistry. 68: 83-91. PMID 12515465 DOI: 10.1021/Jo026479Q |
0.381 |
|
| 2002 |
Luesch H, Yoshida WY, Harrigan GG, Doom JP, Moore RE, Paul VJ. Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp. Journal of Natural Products. 65: 1945-8. PMID 12502348 DOI: 10.1021/Np0202879 |
0.459 |
|
| 2002 |
Luesch H, Williams PG, Yoshida WY, Moore RE, Paul VJ. Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp. Journal of Natural Products. 65: 996-1000. PMID 12141859 DOI: 10.1021/Np0200461 |
0.407 |
|
| 2002 |
Luesch H, Yoshida WY, Moore RE, Paul VJ. New apratoxins of marine cyanobacterial origin from Guam and Palau. Bioorganic & Medicinal Chemistry. 10: 1973-8. PMID 11937357 DOI: 10.1016/S0968-0896(02)00014-7 |
0.506 |
|
| 2002 |
Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL, Corbett TH. Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. Journal of Natural Products. 65: 16-20. PMID 11809057 DOI: 10.1021/Np010317S |
0.459 |
|
| 2001 |
Harrigan GG, Goetz GH, Luesch H, Yang S, Likos J. Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species. Journal of Natural Products. 64: 1133-1138. PMID 11575943 DOI: 10.1021/Np0101999 |
0.391 |
|
| 2001 |
Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. Journal of Natural Products. 64: 907-10. PMID 11473421 DOI: 10.1021/Np010049Y |
0.414 |
|
| 2001 |
Luesch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH. Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. Journal of the American Chemical Society. 123: 5418-23. PMID 11389621 DOI: 10.1021/Ja010453J |
0.456 |
|
| 2001 |
Luesch H, Pangilinan R, Yoshida WY, Moore RE, Paul VJ. Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 64: 304-7. PMID 11277744 DOI: 10.1021/Np000456U |
0.485 |
|
| 2000 |
Luesch H, Yoshida WY, Moore RE, Paul VJ. Isolation and structure of the cytotoxin lyngbyabellin B and absolute configuration of lyngbyapeptin A from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 1437-9. PMID 11076573 DOI: 10.1021/Np000104N |
0.465 |
|
| 2000 |
Luesch H, Yoshida WY, Moore RE, Paul VJ. Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 1106-12. PMID 10978206 DOI: 10.1021/Np000078T |
0.447 |
|
| 2000 |
Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL. Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula. Journal of Natural Products. 63: 611-5. PMID 10843570 DOI: 10.1021/Np990543Q |
0.489 |
|
| 1999 |
Luesch H, Yoshida WY, Moore RE, Paul VJ. Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 62: 1702-6. PMID 10654420 DOI: 10.1021/Np990310Z |
0.415 |
|
| 1999 |
Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ. Symplostatin 2: a dolastatin 13 analogue from the marine cyanobacterium Symploca hydnoides. Journal of Natural Products. 62: 655-8. PMID 10217737 DOI: 10.1021/Np980553B |
0.516 |
|
| 1999 |
Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Biggs J, Park PU, Paul VJ. Tumonoic acids, novel metabolites from a cyanobacterial assemblage of Lyngbya majuscula and Schizothrix calcicola. Journal of Natural Products. 62: 464-7. PMID 10096859 DOI: 10.1021/Np980460U |
0.53 |
|
| 1998 |
Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ, Mooberry SL, Corbett TH, Valeriote FA. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. Journal of Natural Products. 61: 1075-7. PMID 9748368 DOI: 10.1021/Np980321C |
0.444 |
|
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