| Year |
Citation |
Score |
| 2023 |
Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y, Szyf M. Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition. Translational Psychiatry. 13: 259. PMID 37443311 DOI: 10.1038/s41398-023-02561-9 |
0.436 |
|
| 2023 |
Sapozhnikov DM, Szyf M. Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance. Biomedicines. 11. PMID 37238909 DOI: 10.3390/biomedicines11051238 |
0.386 |
|
| 2022 |
Sapozhnikov DM, Szyf M. Enzyme-free targeted DNA demethylation using CRISPR-dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression. Nature Protocols. PMID 36207463 DOI: 10.1038/s41596-022-00741-3 |
0.524 |
|
| 2022 |
Har-Zahav A, Lixandru D, Cheishvili D, Matei IV, Florea IR, Aspritoiu VM, Blus-Kadosh I, Meivar-Levy I, Serban AM, Popescu I, Szyf M, Ferber S, Dima SO. The role of DNA demethylation in liver to pancreas transdifferentiation. Stem Cell Research & Therapy. 13: 476. PMID 36114514 DOI: 10.1186/s13287-022-03159-6 |
0.309 |
|
| 2022 |
Inserra A, Campanale A, Cheishvili D, Dymov S, Wong A, Marcal N, Syme RA, Taylor L, De Gregorio D, Kennedy TE, Szyf M, Gobbi G. Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 110594. PMID 35777526 DOI: 10.1016/j.pnpbp.2022.110594 |
0.364 |
|
| 2022 |
Steiger H, Booij L, Thaler L, St-Hilaire A, Israël M, Casey KF, Oliverio S, Crescenzi O, Lee V, Turecki G, Joober R, Szyf M, Breton É. DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-17. PMID 35703085 DOI: 10.1080/15622975.2022.2089731 |
0.519 |
|
| 2022 |
Ateeq B, Unterberger A, Szyf M, ARabbani S. Corrigendum to "Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo" [Neoplasia 10/3 (2008) 266-278]. Neoplasia (New York, N.Y.). 27: 100777. PMID 35366463 DOI: 10.1016/j.neo.2022.100777 |
0.494 |
|
| 2021 |
Szyf M. The epigenetics of early life adversity and trauma inheritance: an interview with Moshe Szyf. Epigenomics. 14: 309-314. PMID 34877868 DOI: 10.2217/epi-2021-0483 |
0.343 |
|
| 2021 |
Sapozhnikov DM, Szyf M. Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9. Nature Communications. 12: 5711. PMID 34588447 DOI: 10.1038/s41467-021-25991-9 |
0.544 |
|
| 2021 |
Topham L, Gregoire S, Kang H, Salmon-Divon M, Lax E, Millecamps M, Szyf M, Stone L. The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex. Pain Reports. 6: e944. PMID 34278163 DOI: 10.1097/PR9.0000000000000944 |
0.369 |
|
| 2021 |
Warhaftig G, Zifman N, Sokolik CM, Massart R, Gabay O, Sapozhnikov D, Vaisheva F, Lictenstein Y, Confortti N, Ahdoot H, Jacob A, Bareli T, Szyf M, Yadid G. Reduction of DNMT3a and RORA in the nucleus accumbens plays a causal role in post-traumatic stress disorder-like behavior: reversal by combinatorial epigenetic therapy. Molecular Psychiatry. PMID 34253866 DOI: 10.1038/s41380-021-01178-y |
0.35 |
|
| 2021 |
Szyf M. Perinatal stress and epigenetics. Handbook of Clinical Neurology. 180: 125-148. PMID 34225925 DOI: 10.1016/B978-0-12-820107-7.00008-2 |
0.497 |
|
| 2021 |
Cheishvili D, Parashar S, Mahmood N, Arakelian A, Kremer R, Goltzman D, Szyf M, Rabbani SA. Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 34155692 DOI: 10.1002/jbmr.4392 |
0.315 |
|
| 2020 |
Mahmood N, Arakelian A, Cheishvili D, Szyf M, Rabbani SA. S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis. Journal of Cellular and Molecular Medicine. PMID 32720467 DOI: 10.1111/Jcmm.15642 |
0.416 |
|
| 2020 |
Mehdi A, Cheishvili D, Arakelian A, Bismar TA, Szyf M, Rabbani SA. DNA methylation signatures of Prostate Cancer in peripheral T-cells. Bmc Cancer. 20: 588. PMID 32576165 DOI: 10.1186/S12885-020-07078-8 |
0.398 |
|
| 2020 |
Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L. DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents. Journal of Affective Disorders. 271: 160-168. PMID 32479312 DOI: 10.1016/J.Jad.2020.03.062 |
0.442 |
|
| 2020 |
Topham L, Gregoire S, Kang H, Salmon-Divon M, Lax E, Millecamps M, Szyf M, Stone L. The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to one year following nerve injury. Pain. PMID 32427748 DOI: 10.1097/J.Pain.0000000000001917 |
0.406 |
|
| 2020 |
Weinstein-Fudim L, Ergaz Z, Szyf M, Ornoy A. Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA). International Journal of Molecular Sciences. 21. PMID 32325788 DOI: 10.3390/Ijms21082834 |
0.337 |
|
| 2020 |
El-Zein M, Cheishvili D, Gotlieb W, Gilbert L, Hemmings R, Behr MA, Szyf M, Franco EL, Bouten S, Chan A, Massa A, Samios K, Ferenczy A, Ziegler C, et al. Genome-wide DNA methylation profiling identifies two novel genes in cervical neoplasia. International Journal of Cancer. PMID 31983058 DOI: 10.1002/Ijc.32880 |
0.496 |
|
| 2019 |
Szyf M. The epigenetics of perinatal stress
. Dialogues in Clinical Neuroscience. 21: 369-378. PMID 31949404 DOI: 10.31887/Dcns.2019.21.4/Mszyf |
0.517 |
|
| 2019 |
Hoye JR, Cheishvili D, Yarger HA, Roth TL, Szyf M, Dozier M. Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children. Development and Psychopathology. 1-9. PMID 31854285 DOI: 10.1017/S0954579419001421 |
0.431 |
|
| 2019 |
Constantinof A, Boureau L, Moisiadis VG, Kostaki A, Szyf M, Matthews SG. Prenatal Glucocorticoid Exposure Results in Changes in Gene Transcription and DNA Methylation in the Female Juvenile Guinea Pig Hippocampus Across Three Generations. Scientific Reports. 9: 18211. PMID 31796763 DOI: 10.1038/S41598-019-54456-9 |
0.507 |
|
| 2019 |
Grégoire S, Jang SH, Szyf M, Stone LS. Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood. Behavioural Brain Research. 112396. PMID 31786273 DOI: 10.1016/J.Bbr.2019.112396 |
0.315 |
|
| 2019 |
Cao-Lei L, Elgbeili G, Szyf M, Laplante DP, King S. Differential genome-wide DNA methylation patterns in childhood obesity. Bmc Research Notes. 12: 174. PMID 30909978 DOI: 10.1186/S13104-019-4189-0 |
0.375 |
|
| 2019 |
Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E. A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women Journal of Psychiatry & Neuroscience : Jpn. 44: 1-9. PMID 30693739 DOI: 10.1503/Jpn.170242 |
0.522 |
|
| 2019 |
Schmidt M, Lax E, Zhou R, Cheishvili D, Ruder AM, Ludiro A, Lapert F, Macedo da Cruz A, Sandrini P, Calzoni T, Vaisheva F, Brandwein C, Luoni A, Massart R, Lanfumey L, ... ... Szyf M, et al. Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood. Translational Psychiatry. 9: 23. PMID 30655507 DOI: 10.1038/S41398-018-0348-7 |
0.593 |
|
| 2019 |
Nemoda Z, Yu W, Sante JD, Suderman M, Kruk E, Fazekas K, Unoka Z, Tremblay RE, Szyf M, Booij L. Does It Matter Which Cells We Use In Dna Methylation Analyses Of Glucocorticoid Signaling Genes European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.358 |
0.56 |
|
| 2018 |
Cecil CAM, Walton E, Pingault JB, Provençal N, Pappa I, Vitaro F, Côté S, Szyf M, Tremblay RE, Tiemeier H, Viding E, McCrory EJ. DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 30411855 DOI: 10.1002/Ajmg.B.32689 |
0.423 |
|
| 2018 |
Lax E, Warhaftig G, Ohana D, Maayan R, Delayahu Y, Roska P, Ponizovsky AM, Weizman A, Yadid G, Szyf M. A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention. Frontiers in Molecular Neuroscience. 11: 322. PMID 30250424 DOI: 10.3389/Fnmol.2018.00322 |
0.576 |
|
| 2018 |
Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L. Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Translational Psychiatry. 8: 147. PMID 30089832 DOI: 10.1038/S41398-018-0195-6 |
0.522 |
|
| 2018 |
Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L. Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates. Psychoneuroendocrinology. 97: 196-205. PMID 30059826 DOI: 10.1016/J.Psyneuen.2018.07.019 |
0.586 |
|
| 2018 |
Lax E, Szyf M. The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics. Progress in Molecular Biology and Translational Science. 157: 93-104. PMID 29933958 DOI: 10.1016/Bs.Pmbts.2018.01.003 |
0.515 |
|
| 2018 |
Cheishvili D, Parashar S, Mahmood N, Arakelian A, Kremer R, Goltzman D, Szyf M, Rabbani SA. Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Post-menopausal Women. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 29924424 DOI: 10.1002/Jbmr.3527 |
0.48 |
|
| 2018 |
Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V. DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse. Psychiatry Research. 265: 341-348. PMID 29793048 DOI: 10.1016/J.Psychres.2018.04.064 |
0.479 |
|
| 2018 |
Parashar S, Cheishvili D, Mahmood N, Arakelian A, Tanvir I, Khan HA, Kremer R, Mihalcioiu C, Szyf M, Rabbani SA. DNA methylation signatures of breast cancer in peripheral T-cells. Bmc Cancer. 18: 574. PMID 29776342 DOI: 10.1186/s12885-018-4482-7 |
0.424 |
|
| 2018 |
Boureau L, Constantinof A, Moisiadis VG, Matthews SG, Szyf M. The DNA methylation landscape of enhancers in the guinea pig hippocampus. Epigenomics. 10: 349-365. PMID 29616589 DOI: 10.2217/Epi-2017-0064 |
0.585 |
|
| 2018 |
Mahmood N, Cheishvili D, Arakelian A, Tanvir I, Khan HA, Pépin AS, Szyf M, Rabbani SA. Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications. Oncotarget. 9: 5169-5183. PMID 29435170 DOI: 10.18632/Oncotarget.23704 |
0.358 |
|
| 2018 |
Cao-Lei L, Dancause KN, Elgbeili G, Laplante DP, Szyf M, King S. DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child's C-peptide secretion in adolescence: Project Ice Storm. Plos One. 13: e0192199. PMID 29401509 DOI: 10.1371/Journal.Pone.0192199 |
0.451 |
|
| 2018 |
Zhang Y, Petropoulos S, Liu J, Cheishvili D, Zhou R, Dymov S, Li K, Li N, Szyf M. The signature of liver cancer in immune cells DNA methylation. Clinical Epigenetics. 10: 8. PMID 29375724 DOI: 10.1186/S13148-017-0436-1 |
0.399 |
|
| 2018 |
Ornoy A, Weinstein-Fudim L, Tfilin M, Ergaz Z, Yanai J, Szyf M, Turgeman G. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicology and Teratology. PMID 29343446 DOI: 10.1016/J.Ntt.2018.01.005 |
0.335 |
|
| 2018 |
Mahmood N, Cheishvili D, Arakelian A, Muller WJ, Tanveer I, Khan H, Szyf M, Rabbani SA. Abstract A09: Development of epigenetic-based strategies for blocking breast cancer growth, invasion, and metastasis in vitro and in vivo Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Tcm17-A09 |
0.349 |
|
| 2018 |
Mahmood N, Arakelian A, Muller WJ, Szyf M, Rabbani SA. Abstract 1388: Pharmacologic targeting of DNA methylation blocks breast cancer growth and metastasis Cancer Research. 78: 1388-1388. DOI: 10.1158/1538-7445.Am2018-1388 |
0.454 |
|
| 2017 |
Wang Y, Sun Z, Szyf M. S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells. Oncotarget. 8: 111866-111881. PMID 29340097 DOI: 10.18632/Oncotarget.22942 |
0.344 |
|
| 2017 |
Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T. Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29182159 DOI: 10.1038/Npp.2017.290 |
0.372 |
|
| 2017 |
Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Körner C, Furth N, Lauriola M, ... ... Szyf M, et al. Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone. Nucleic Acids Research. PMID 29036586 DOI: 10.1093/Nar/Gkx865 |
0.473 |
|
| 2017 |
Gouin JP, Zhou QQ, Booij L, Boivin M, Côté SM, Hébert M, Ouellet-Morin I, Szyf M, Tremblay RE, Turecki G, Vitaro F. Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness. Scientific Reports. 7: 7446. PMID 28785027 DOI: 10.1038/S41598-017-07950-X |
0.425 |
|
| 2017 |
Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L. Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 28774705 DOI: 10.1016/J.Euroneuro.2017.07.005 |
0.488 |
|
| 2017 |
Nemoda Z, Szyf M. Epigenetic Alterations and Prenatal Maternal Depression. Birth Defects Research. 109: 888-897. PMID 28714605 DOI: 10.1002/Bdr2.1081 |
0.537 |
|
| 2017 |
Cao-Lei L, De Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M. Prenatal Stress and Epigenetics. Neuroscience and Biobehavioral Reviews. PMID 28528960 DOI: 10.1016/J.Neubiorev.2017.05.016 |
0.439 |
|
| 2017 |
Massart R, Suderman M, Mongrain V, Szyf M. DNA methylation and transcription onset in the brain. Epigenomics. PMID 28517952 DOI: 10.2217/Epi-2016-0184 |
0.57 |
|
| 2017 |
Cheishvili D, Christiansen S, Stochinsky R, Pepin AS, Sapozhnikov DM, Zhou R, Schmeltzer L, Dymov S, Szyf M. DNA methylation controls unmethylated transcription start sites in the genome in trans. Epigenomics. PMID 28470094 DOI: 10.2217/Epi-2016-0141 |
0.608 |
|
| 2017 |
Cheishvili D, Szyf M. Abstract 4349: Adverse & anticancer activities of 5-azaCdR & DNA methyltransferase (DNMT) isoform specific inhibitors: therapeutic implications Cancer Research. 77: 4349-4349. DOI: 10.1158/1538-7445.Am2017-4349 |
0.505 |
|
| 2017 |
Ornoy A, Weinstein-Fudim L, Szyf M, Ergaz Z. High sucrose low copper diet in diabetic and non-diabetic pregnant rats induces long-term changes in the offspring epigenome manifested by DNA hypo-methylation of critical developmental genes Reproductive Toxicology. 72: 25-26. DOI: 10.1016/J.Reprotox.2017.06.063 |
0.39 |
|
| 2017 |
Carmo SD, Jacobs ML, Lax EM, Hall H, Ritson J, Iulita MF, Yang J, Yu L, Ducatenzeiler A, Bennett DA, Szyf M, Cuello AC. [P4-035]: AMYLOID β-DRIVEN DNA DEMETHYLATION AS A TARGET FOR ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P1269-P1270. DOI: 10.1016/J.Jalz.2017.06.1899 |
0.352 |
|
| 2016 |
Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L. Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Human Brain Mapping. PMID 28032437 DOI: 10.1002/Hbm.23503 |
0.502 |
|
| 2016 |
Grégoire S, Millecamps M, Naso L, Carmo SD, Cuello AC, Szyf M, Stone LS. Therapeutic benefits of the methyl donor S-adenosylmethionine (SAM) on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice. Pain. PMID 28030474 DOI: 10.1097/J.Pain.0000000000000811 |
0.502 |
|
| 2016 |
Luoni A, Massart R, Nieratschker V, Nemoda Z, Blasi G, Gilles M, Witt SH, Suderman MJ, Suomi SJ, Porcelli A, Rizzo G, Fazio L, Torretta S, Rampino A, Berry A, ... ... Szyf M, et al. Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders. Translational Psychiatry. 6: e943. PMID 27824361 DOI: 10.1038/Tp.2016.211 |
0.344 |
|
| 2016 |
Richetto J, Massart R, Weber-Stadlbauer U, Szyf M, Riva MA, Meyer U. Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders. Biological Psychiatry. PMID 27769567 DOI: 10.1016/J.Biopsych.2016.08.010 |
0.483 |
|
| 2016 |
Massart R, Suderman MJ, Nemoda Z, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M. The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys. Child Development. PMID 27739069 DOI: 10.1111/Cdev.12640 |
0.401 |
|
| 2016 |
Szyf M. The elusive role of 5'-hydroxymethylcytosine. Epigenomics. PMID 27733056 DOI: 10.2217/Epi-2016-0076 |
0.541 |
|
| 2016 |
Cao-Lei L, Dancause KN, Elgbeili G, Laplante DP, Szyf M, King S. Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm. Early Human Development. 103: 189-192. PMID 27718477 DOI: 10.1016/J.Earlhumdev.2016.09.013 |
0.489 |
|
| 2016 |
Massart R, Nemoda Z, Suderman MJ, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M. Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation. Development and Psychopathology. 1-14. PMID 27687908 DOI: 10.1017/S0954579416000833 |
0.572 |
|
| 2016 |
Do Carmo S, Hanzel CE, Jacobs ML, Machnes Z, Iulita MF, Yang J, Yu L, Ducatenzeiler A, Danik M, Breuillaud LS, Bennett DA, Szyf M, Cuello AC. Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer's Model. Scientific Reports. 6: 34051. PMID 27681803 DOI: 10.1038/Srep34051 |
0.438 |
|
| 2016 |
Cao-Lei L, Veru F, Elgbeili G, Szyf M, Laplante DP, King S. DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm. Clinical Epigenetics. 8: 54. PMID 27182285 DOI: 10.1186/S13148-016-0219-0 |
0.436 |
|
| 2016 |
Szyf M, Tang YY, Hill KG, Musci R. The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion. Translational Behavioral Medicine. 6: 55-62. PMID 27012253 DOI: 10.1007/S13142-016-0387-7 |
0.575 |
|
| 2016 |
Naumova OY, Hein S, Suderman M, Barbot B, Lee M, Raefski A, Dobrynin PV, Brown PJ, Szyf M, Luthar SS, Grigorenko EL. Epigenetic Patterns Modulate the Connection Between Developmental Dynamics of Parenting and Offspring Psychosocial Adjustment. Child Development. 87: 98-110. PMID 26822446 DOI: 10.1111/Cdev.12485 |
0.393 |
|
| 2016 |
Massart R, Dymov S, Millecamps M, Suderman M, Gregoire S, Koenigs K, Alvarado S, Tajerian M, Stone LS, Szyf M. Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells. Scientific Reports. 6: 19615. PMID 26817950 DOI: 10.1038/Srep19615 |
0.797 |
|
| 2016 |
Booij L, Levesque ML, Fahim C, Ismaylova E, Vitaro F, Brendgen M, Dionne G, Boivin M, Szyf M, Tremblay RE. Serotonin transporter methylation, neural responses to sadness and resting state functional connectivity: a study in adolescent monozygotic twins European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)31300-1 |
0.317 |
|
| 2016 |
Farrell C, O’Keane V, Harkin A, O’Leary N, Jairaj C, Booij L, Szyf M. Association of maternal emotional abuse with decreased serotonin transporter gene (SLC6A4) methylation European Neuropsychopharmacology. 26: S177. DOI: 10.1016/S0924-977X(16)31006-9 |
0.361 |
|
| 2016 |
Carmo SD, Jacobs ML, Machnes Z, Iulita MF, Yang J, Yu L, Ducatenzeiler A, Wilson EN, Bennett DA, Szyf M, Cuello AC. Dna Demethylation And Remethylation In Alzheimer’S Pathology Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.399 |
0.526 |
|
| 2015 |
Chiarella J, Tremblay RE, Szyf M, Provençal N, Booij L. Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins. Twin Research and Human Genetics : the Official Journal of the International Society For Twin Studies. 18: 623-34. PMID 26608878 DOI: 10.1017/Thg.2015.84 |
0.448 |
|
| 2015 |
Cheishvili D, Stefanska B, Yi C, Chen Li C, Yu P, Arakelian A, Tanvir I, Ahmed Khan H, Rabbani S, Szyf M. A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness. Oncotarget. PMID 26427334 DOI: 10.18632/Oncotarget.5291 |
0.443 |
|
| 2015 |
Suderman M, Pappas JJ, Borghol N, Buxton JL, McArdle WL, Ring SM, Hertzman C, Power C, Szyf M, Pembrey M. Lymphoblastoid cell lines reveal associations of adult DNA methylation with childhood and current adversity that are distinct from whole blood associations. International Journal of Epidemiology. 44: 1331-40. PMID 26351305 DOI: 10.1093/Ije/Dyv168 |
0.527 |
|
| 2015 |
Cao-Lei L, Dancause KN, Elgbeili G, Massart R, Szyf M, Liu A, Laplante DP, King S. DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13½ years: Project Ice Storm. Epigenetics : Official Journal of the Dna Methylation Society. 0. PMID 26098974 DOI: 10.1080/15592294.2015.1063771 |
0.464 |
|
| 2015 |
Massart R, Barnea R, Dikshtein Y, Suderman M, Meir O, Hallett M, Kennedy P, Nestler EJ, Szyf M, Yadid G. Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8042-58. PMID 26019323 DOI: 10.1523/Jneurosci.3053-14.2015 |
0.356 |
|
| 2015 |
Szyf M. Prospects for the development of epigenetic drugs for CNS conditions. Nature Reviews. Drug Discovery. 14: 461-74. PMID 26000723 DOI: 10.1038/Nrd4580 |
0.345 |
|
| 2015 |
Alvarado S, Mak T, Liu S, Storey KB, Szyf M. Dynamic changes in global and gene-specific DNA methylation during hibernation in adult thirteen-lined ground squirrels, Ictidomys tridecemlineatus. The Journal of Experimental Biology. 218: 1787-95. PMID 25908059 DOI: 10.1242/Jeb.116046 |
0.615 |
|
| 2015 |
Alvarado S, Tajerian M, Suderman M, Machnes Z, Pierfelice S, Millecamps M, Stone LS, Szyf M. An epigenetic hypothesis for the genomic memory of pain. Frontiers in Cellular Neuroscience. 9: 88. PMID 25852480 DOI: 10.3389/Fncel.2015.00088 |
0.791 |
|
| 2015 |
Nemoda Z, Massart R, Suderman M, Hallett M, Li T, Coote M, Cody N, Sun ZS, Soares CN, Turecki G, Steiner M, Szyf M. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. Translational Psychiatry. 5: e545. PMID 25849984 DOI: 10.1038/Tp.2015.32 |
0.488 |
|
| 2015 |
Frodl T, Szyf M, Carballedo A, Ly V, Dymov S, Vaisheva F, Morris D, Fahey C, Meaney J, Gill M, Booij L. DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli. Journal of Psychiatry & Neuroscience : Jpn. 40: 140180. PMID 25825812 DOI: 10.1503/Jpn.140180 |
0.486 |
|
| 2015 |
Booij L, Casey KF, Antunes JM, Szyf M, Joober R, Israël M, Steiger H. DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls: A genome-wide study. The International Journal of Eating Disorders. PMID 25808061 DOI: 10.1002/Eat.22374 |
0.511 |
|
| 2015 |
Booij L, Szyf M, Carballedo A, Frey EM, Morris D, Dymov S, Vaisheva F, Ly V, Fahey C, Meaney J, Gill M, Frodl T. DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls. Plos One. 10: e0119061. PMID 25781010 DOI: 10.1371/Journal.Pone.0119061 |
0.421 |
|
| 2015 |
Alvarado S, Rajakumar R, Abouheif E, Szyf M. Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants. Nature Communications. 6: 6513. PMID 25758336 DOI: 10.1038/Ncomms7513 |
0.496 |
|
| 2015 |
Cao-Lei L, Elgbeili G, Massart R, Laplante DP, Szyf M, King S. Pregnant women's cognitive appraisal of a natural disaster affects DNA methylation in their children 13 years later: Project Ice Storm. Translational Psychiatry. 5: e515. PMID 25710121 DOI: 10.1038/Tp.2015.13 |
0.498 |
|
| 2015 |
Shukeir N, Stefanska B, Parashar S, Chik F, Arakelian A, Szyf M, Rabbani SA. Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo. British Journal of Pharmacology. 172: 2769-81. PMID 25631332 DOI: 10.1111/Bph.13102 |
0.495 |
|
| 2015 |
Petropoulos S, Guillemin C, Ergaz Z, Dimov S, Suderman M, Weinstein-Fudim L, Ornoy A, Szyf M. Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling. Endocrinology. 156: 2222-38. PMID 25514087 DOI: 10.1210/En.2014-1643 |
0.454 |
|
| 2015 |
Cheishvili D, Boureau L, Szyf M. DNA demethylation and invasive cancer: implications for therapeutics. British Journal of Pharmacology. 172: 2705-15. PMID 25134627 DOI: 10.1111/Bph.12885 |
0.539 |
|
| 2015 |
Szyf M. Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 25: 682-702. PMID 24857313 DOI: 10.1016/J.Euroneuro.2014.01.009 |
0.455 |
|
| 2015 |
Nagy C, Suderman M, Yang J, Szyf M, Mechawar N, Ernst C, Turecki G. Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Molecular Psychiatry. 20: 320-8. PMID 24662927 DOI: 10.1038/Mp.2014.21 |
0.49 |
|
| 2015 |
Szyf M. DNA methylation mediating the impact of exposure on behavior Neurotoxicology and Teratology. 49: 144. DOI: 10.1016/J.Ntt.2015.04.141 |
0.522 |
|
| 2015 |
Gregoire S, Massart R, Dymov S, Millecamps M, Szyf M, Stone L. (252) Broad and highly organized changes in DNA methylation in prefrontal cortex and T cells in a model of chronic neuropathic pain in rats The Journal of Pain. 16: S39. DOI: 10.1016/j.jpain.2015.01.169 |
0.326 |
|
| 2014 |
Szyf M. Examining peripheral DNA methylation in behavioral epigenetic and epigenetic psychiatry: opportunities and challenges. Epigenomics. 6: 581-4. PMID 25531252 DOI: 10.2217/Epi.14.57 |
0.573 |
|
| 2014 |
Lévesque ML, Casey KF, Szyf M, Ismaylova E, Ly V, Verner MP, Suderman M, Brendgen M, Vitaro F, Dionne G, Boivin M, Tremblay RE, Booij L. Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth. Epigenetics : Official Journal of the Dna Methylation Society. 9: 1410-21. PMID 25437055 DOI: 10.4161/15592294.2014.970060 |
0.549 |
|
| 2014 |
Pappas JJ, Petropoulos S, Suderman M, Iqbal M, Moisiadis V, Turecki G, Matthews SG, Szyf M. The multidrug resistance 1 gene Abcb1 in brain and placenta: comparative analysis in human and guinea pig. Plos One. 9: e111135. PMID 25353162 DOI: 10.1371/Journal.Pone.0111135 |
0.316 |
|
| 2014 |
Cao-Lei L, Massart R, Suderman MJ, Machnes Z, Elgbeili G, Laplante DP, Szyf M, King S. DNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm. Plos One. 9: e107653. PMID 25238154 DOI: 10.1371/Journal.Pone.0107653 |
0.381 |
|
| 2014 |
Cheishvili D, Chik F, Li CC, Bhattacharya B, Suderman M, Arakelian A, Hallett M, Rabbani SA, Szyf M. Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness. Carcinogenesis. 35: 2436-46. PMID 25178277 DOI: 10.1093/Carcin/Bgu181 |
0.51 |
|
| 2014 |
Nieratschker V, Massart R, Gilles M, Luoni A, Suderman MJ, Krumm B, Meier S, Witt SH, Nöthen MM, Suomi SJ, Peus V, Scharnholz B, Dukal H, Hohmeyer C, Wolf IA, ... ... Szyf M, et al. MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD. Translational Psychiatry. 4: e429. PMID 25158004 DOI: 10.1038/Tp.2014.75 |
0.37 |
|
| 2014 |
Weaver IC, Hellstrom IC, Brown SE, Andrews SD, Dymov S, Diorio J, Zhang TY, Szyf M, Meaney MJ. The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369. PMID 25135974 DOI: 10.1098/Rstb.2013.0513 |
0.475 |
|
| 2014 |
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, ... ... Szyf M, et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience. 17: 1156-63. PMID 25129075 DOI: 10.1038/Nn.3786 |
0.473 |
|
| 2014 |
Buxton JL, Suderman M, Pappas JJ, Borghol N, McArdle W, Blakemore AI, Hertzman C, Power C, Szyf M, Pembrey M. Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci. Scientific Reports. 4: 4954. PMID 24828261 DOI: 10.1038/Srep04954 |
0.563 |
|
| 2014 |
Alvarado S, Fernald RD, Storey KB, Szyf M. The dynamic nature of DNA methylation: a role in response to social and seasonal variation. Integrative and Comparative Biology. 54: 68-76. PMID 24813708 DOI: 10.1093/icb/icu034 |
0.511 |
|
| 2014 |
Stefanska B, Cheishvili D, Suderman M, Arakelian A, Huang J, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Tanvir I, Khan HA, Rabbani SA, Szyf M. Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 3118-32. PMID 24763612 DOI: 10.1158/1078-0432.Ccr-13-0283 |
0.355 |
|
| 2014 |
Provençal N, Suderman MJ, Guillemin C, Vitaro F, Côté SM, Hallett M, Tremblay RE, Szyf M. Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells. Plos One. 9: e89839. PMID 24691403 DOI: 10.1371/Journal.Pone.0089839 |
0.505 |
|
| 2014 |
Massart R, Suderman M, Provencal N, Yi C, Bennett AJ, Suomi S, Szyf M. Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation. Neuroscience. 268: 139-48. PMID 24657458 DOI: 10.1016/J.Neuroscience.2014.03.021 |
0.503 |
|
| 2014 |
Suderman M, Borghol N, Pappas JJ, Pinto Pereira SM, Pembrey M, Hertzman C, Power C, Szyf M. Childhood abuse is associated with methylation of multiple loci in adult DNA. Bmc Medical Genomics. 7: 13. PMID 24618023 DOI: 10.1186/1755-8794-7-13 |
0.554 |
|
| 2014 |
Ergaz Z, Guillemin C, Neeman-Azulay M, Weinstein-Fudim L, Stodgell CJ, Miller RK, Szyf M, Ornoy A. Placental oxidative stress and decreased global DNA methylation are corrected by copper in the Cohen diabetic rat. Toxicology and Applied Pharmacology. 276: 220-30. PMID 24593922 DOI: 10.1016/J.Taap.2014.02.017 |
0.368 |
|
| 2014 |
Guillemin C, Provençal N, Suderman M, Côté SM, Vitaro F, Hallett M, Tremblay RE, Szyf M. DNA methylation signature of childhood chronic physical aggression in T cells of both men and women. Plos One. 9: e86822. PMID 24475181 DOI: 10.1371/Journal.Pone.0086822 |
0.441 |
|
| 2014 |
Petropoulos S, Matthews SG, Szyf M. Adult glucocorticoid exposure leads to transcriptional and DNA methylation changes in nuclear steroid receptors in the hippocampus and kidney of mouse male offspring. Biology of Reproduction. 90: 43. PMID 24451982 DOI: 10.1095/Biolreprod.113.115899 |
0.447 |
|
| 2014 |
Schwimmer H, Metzer A, Pilosof Y, Szyf M, Machnes ZM, Fares F, Harel O, Haim A. Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation Chronobiology International. 31: 144-150. PMID 24131150 DOI: 10.3109/07420528.2013.842925 |
0.389 |
|
| 2014 |
Chik F, Machnes Z, Szyf M. Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine. Carcinogenesis. 35: 138-44. PMID 23985780 DOI: 10.1093/Carcin/Bgt284 |
0.541 |
|
| 2014 |
Nemoda Z, Steiner M, Li T, Coote M, Massart R, Suderman M, Soares C, Szyf M. Maternal mood disorder is associated with a distinct DNA methylation signature in neonatal cord blood F1000research. 5. DOI: 10.7490/F1000Research.1095661.1 |
0.384 |
|
| 2014 |
Tajerian M, Alvarado S, Millecamps M, Szyf M, Stone LS. The epigenetic signature of chronic pain in the mouse brain Molecular Pain. 10: O17. DOI: 10.1186/1744-8069-10-S1-O17 |
0.743 |
|
| 2013 |
Szyf M. The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 58: 697-704. PMID 24331290 DOI: 10.1177/070674371305801208 |
0.529 |
|
| 2013 |
Alvarado S, Wyglinski J, Suderman M, Andrews SA, Szyf M. Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. Plos One. 8: e74009. PMID 24204564 DOI: 10.1371/Journal.Pone.0074009 |
0.385 |
|
| 2013 |
Machnes ZM, Huang TC, Chang PK, Gill R, Reist N, Dezsi G, Ozturk E, Charron F, O'Brien TJ, Jones NC, McKinney RA, Szyf M. DNA methylation mediates persistent epileptiform activity in vitro and in vivo. Plos One. 8: e76299. PMID 24098468 DOI: 10.1371/Journal.Pone.0076299 |
0.527 |
|
| 2013 |
Crudo A, Petropoulos S, Suderman M, Moisiadis VG, Kostaki A, Hallett M, Szyf M, Matthews SG. Effects of antenatal synthetic glucocorticoid on glucocorticoid receptor binding, DNA methylation, and genome-wide mRNA levels in the fetal male hippocampus. Endocrinology. 154: 4170-81. PMID 24029241 DOI: 10.1210/En.2013-1484 |
0.534 |
|
| 2013 |
Provençal N, Suderman MJ, Caramaschi D, Wang D, Hallett M, Vitaro F, Tremblay RE, Szyf M. Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. Plos One. 8: e71691. PMID 23977113 DOI: 10.1371/Journal.Pone.0071691 |
0.388 |
|
| 2013 |
Stefanska B, Suderman M, Machnes Z, Bhattacharyya B, Hallett M, Szyf M. Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. Carcinogenesis. 34: 2738-49. PMID 23955541 DOI: 10.1093/Carcin/Bgt273 |
0.545 |
|
| 2013 |
Stefanska B, Bouzelmat A, Huang J, Suderman M, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Szyf M. Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. Plos One. 8: e68439. PMID 23950870 DOI: 10.1371/Journal.Pone.0068439 |
0.407 |
|
| 2013 |
Szyf M. DNA methylation, behavior and early life adversity. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 40: 331-8. PMID 23876773 DOI: 10.1016/J.Jgg.2013.06.004 |
0.48 |
|
| 2013 |
Alvarado S, Tajerian M, Millecamps M, Suderman M, Stone LS, Szyf M. Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex. Molecular Pain. 9: 21. PMID 23597049 DOI: 10.1186/1744-8069-9-21 |
0.708 |
|
| 2013 |
Labonté B, Suderman M, Maussion G, Lopez JP, Navarro-Sánchez L, Yerko V, Mechawar N, Szyf M, Meaney MJ, Turecki G. Genome-wide methylation changes in the brains of suicide completers. The American Journal of Psychiatry. 170: 511-20. PMID 23511308 DOI: 10.1176/Appi.Ajp.2012.12050627 |
0.562 |
|
| 2013 |
Suderman M, Borghol N, Pappas JJ, McArdle W, Racine A, Hallett MT, Pembrey ME, Hertzman C, Power C, Szyf M. Epigenomic socioeconomic studies more similar than different. Proceedings of the National Academy of Sciences of the United States of America. 110: E1246. PMID 23493547 DOI: 10.1073/Pnas.1221019110 |
0.399 |
|
| 2013 |
Szyf M. DNA demethylation and cancer metastasis: therapeutic implications. Expert Opinion On Drug Discovery. 3: 519-31. PMID 23484924 DOI: 10.1517/17460441.3.5.519 |
0.604 |
|
| 2013 |
Booij L, Wang D, Lévesque ML, Tremblay RE, Szyf M. Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20120251. PMID 23440465 DOI: 10.1098/Rstb.2012.0251 |
0.541 |
|
| 2013 |
Crudo A, Suderman M, Moisiadis VG, Petropoulos S, Kostaki A, Hallett M, Szyf M, Matthews SG. Glucocorticoid programming of the fetal male hippocampal epigenome. Endocrinology. 154: 1168-80. PMID 23389956 DOI: 10.1210/En.2012-1980 |
0.469 |
|
| 2013 |
Tajerian M, Alvarado S, Millecamps M, Vachon P, Crosby C, Bushnell MC, Szyf M, Stone LS. Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. Plos One. 8: e55259. PMID 23383129 DOI: 10.1371/Journal.Pone.0055259 |
0.751 |
|
| 2013 |
Szyf M, Bick J. DNA methylation: a mechanism for embedding early life experiences in the genome. Child Development. 84: 49-57. PMID 22880724 DOI: 10.1111/J.1467-8624.2012.01793.X |
0.498 |
|
| 2013 |
Kabro A, Lachance H, Marcoux-Archambault I, Perrier V, Doré V, Gros C, Masson V, Gregoire JM, Ausseil F, Cheishvili D, Laulan NB, St-Pierre Y, Szyf M, Arimondo PB, Gagnon A. Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity Medchemcomm. 4: 1562-1570. DOI: 10.1039/C3Md00214D |
0.531 |
|
| 2012 |
Provençal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, Bennett AJ, Pierre PJ, Friedman DP, Côté SM, Hallett M, Tremblay RE, Suomi SJ, Szyf M. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15626-42. PMID 23115197 DOI: 10.1523/Jneurosci.1470-12.2012 |
0.55 |
|
| 2012 |
Suderman M, McGowan PO, Sasaki A, Huang TC, Hallett MT, Meaney MJ, Turecki G, Szyf M. Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 109: 17266-72. PMID 23045659 DOI: 10.1073/Pnas.1121260109 |
0.523 |
|
| 2012 |
Szyf M. Mind-body interrelationship in DNA methylation. Chemical Immunology and Allergy. 98: 85-99. PMID 22767059 DOI: 10.1159/000336503 |
0.61 |
|
| 2012 |
Labonté B, Suderman M, Maussion G, Navaro L, Yerko V, Mahar I, Bureau A, Mechawar N, Szyf M, Meaney MJ, Turecki G. Genome-wide epigenetic regulation by early-life trauma. Archives of General Psychiatry. 69: 722-31. PMID 22752237 DOI: 10.1001/Archgenpsychiatry.2011.2287 |
0.593 |
|
| 2012 |
Wang D, Szyf M, Benkelfat C, Provençal N, Turecki G, Caramaschi D, Côté SM, Vitaro F, Tremblay RE, Booij L. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. Plos One. 7: e39501. PMID 22745770 DOI: 10.1371/Journal.Pone.0039501 |
0.52 |
|
| 2012 |
Crudo A, Petropoulos S, Moisiadis VG, Iqbal M, Kostaki A, Machnes Z, Szyf M, Matthews SG. Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects. Endocrinology. 153: 3269-83. PMID 22564977 DOI: 10.1210/En.2011-2160 |
0.561 |
|
| 2012 |
Szyf M. DNA methylation signatures for breast cancer classification and prognosis. Genome Medicine. 4: 26. PMID 22494847 DOI: 10.1186/Gm325 |
0.545 |
|
| 2012 |
Labonte B, Yerko V, Gross J, Mechawar N, Meaney MJ, Szyf M, Turecki G. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biological Psychiatry. 72: 41-8. PMID 22444201 DOI: 10.1016/J.Biopsych.2012.01.034 |
0.443 |
|
| 2012 |
Szyf M. Inflammation and age-dependent DNA demethylation. Epigenomics. 4: 16. PMID 22435124 |
0.343 |
|
| 2012 |
Szyf M. Genes methylated in cancer that are resistant to activation by DNA demethylating agents and histone deacetylase inhibitors. Epigenomics. 4: 15. PMID 22435123 |
0.439 |
|
| 2012 |
Szyf M. DNA methylation biomarkers for colorectal carcinoma and adenomatous polyps. Epigenomics. 4: 14-5. PMID 22435121 |
0.42 |
|
| 2012 |
Borghol N, Suderman M, McArdle W, Racine A, Hallett M, Pembrey M, Hertzman C, Power C, Szyf M. Associations with early-life socio-economic position in adult DNA methylation. International Journal of Epidemiology. 41: 62-74. PMID 22422449 DOI: 10.1093/Ije/Dyr147 |
0.447 |
|
| 2012 |
Szyf M. Heterogeneous DNA methylation as an early marker of cancer. Epigenomics. 4: 13-4. PMID 22332654 DOI: 10.2217/Epi.11.115 |
0.548 |
|
| 2012 |
Szyf M. The early-life social environment and DNA methylation. Clinical Genetics. 81: 341-9. PMID 22236068 DOI: 10.1111/J.1399-0004.2012.01843.X |
0.598 |
|
| 2012 |
Naumova OY, Lee M, Koposov R, Szyf M, Dozier M, Grigorenko EL. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents. Development and Psychopathology. 24: 143-55. PMID 22123582 DOI: 10.1017/S0954579411000605 |
0.451 |
|
| 2012 |
Machnes ZM, Stefanska B, Szyf M. Abstract 4103: Hepatocellular carcinoma-specific isoforms of methylated DNA-binding protein 2 and their therapeutic and diagnostic potential Cancer Research. 72: 4103-4103. DOI: 10.1158/1538-7445.Am2012-4103 |
0.457 |
|
| 2012 |
Stefanska B, Suderman M, Huang J, Hallett M, Han Z, Szyf M. Abstract 4028: Therapeutic relevance of two novel cancer candidate genes,RASAL2andNENF, activated by DNA hypomethylation Cancer Research. 72: 4028-4028. DOI: 10.1158/1538-7445.Am2012-4028 |
0.431 |
|
| 2011 |
Chik F, Szyf M, Rabbani SA. Role of epigenetics in cancer initiation and progression. Advances in Experimental Medicine and Biology. 720: 91-104. PMID 21901621 DOI: 10.1007/978-1-4614-0254-1_8 |
0.433 |
|
| 2011 |
Tajerian M, Alvarado S, Millecamps M, Dashwood T, Anderson KM, Haglund L, Ouellet J, Szyf M, Stone LS. DNA methylation of SPARC and chronic low back pain. Molecular Pain. 7: 65. PMID 21867537 DOI: 10.1186/1744-8069-7-65 |
0.802 |
|
| 2011 |
Szyf M. The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics. 6: 971-8. PMID 21772123 DOI: 10.4161/Epi.6.8.16793 |
0.539 |
|
| 2011 |
Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M, Han ZG, Szyf M. Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer Research. 71: 5891-903. PMID 21747116 DOI: 10.1158/0008-5472.Can-10-3823 |
0.502 |
|
| 2011 |
Szyf M. DNA methylation, the early-life social environment and behavioral disorders. Journal of Neurodevelopmental Disorders. 3: 238-49. PMID 21484196 DOI: 10.1007/S11689-011-9079-2 |
0.45 |
|
| 2011 |
McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, Szyf M. Broad epigenetic signature of maternal care in the brain of adult rats. Plos One. 6: e14739. PMID 21386994 DOI: 10.1371/Journal.Pone.0014739 |
0.427 |
|
| 2011 |
Szyf M. The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 235-55. PMID 21297083 DOI: 10.1093/Toxsci/Kfr024 |
0.519 |
|
| 2011 |
Chik F, Szyf M. Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis. 32: 224-32. PMID 20980350 DOI: 10.1093/Carcin/Bgq221 |
0.52 |
|
| 2011 |
Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, et al. Child health, developmental plasticity, and epigenetic programming. Endocrine Reviews. 32: 159-224. PMID 20971919 DOI: 10.1210/Er.2009-0039 |
0.332 |
|
| 2011 |
Stefanska B, Bhattacharyya B, Suderman M, Huang J, Hallett M, Han Z, Szyf M. Abstract 96: The functional role of DNA hypomethylation in liver cancer Cancer Research. 71: 96-96. DOI: 10.1158/1538-7445.Am2011-96 |
0.465 |
|
| 2011 |
Szyf M. The implication of DNA methylation on toxicology: Towards toxicomethylomics; the toxicology of DNA methylation Reproductive Toxicology. 31: 249-249. DOI: 10.1016/J.Reprotox.2010.12.059 |
0.613 |
|
| 2010 |
Szyf M. A dynamic methylome; implications of non-CG methylation/demethylation. Cell Cycle (Georgetown, Tex.). 9: 3846-7. PMID 20948285 DOI: 10.4161/Cc.9.19.13563 |
0.421 |
|
| 2010 |
Szyf M. DNA methylation and demethylation probed by small molecules. Biochimica Et Biophysica Acta. 1799: 750-9. PMID 20840878 DOI: 10.1016/J.Bbagrm.2010.09.002 |
0.636 |
|
| 2010 |
McGowan PO, Szyf M. Environmental epigenomics: understanding the effects of parental care on the epigenome. Essays in Biochemistry. 48: 275-87. PMID 20822499 DOI: 10.1042/Bse0480275 |
0.473 |
|
| 2010 |
McGowan PO, Szyf M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiology of Disease. 39: 66-72. PMID 20053376 DOI: 10.1016/J.Nbd.2009.12.026 |
0.463 |
|
| 2010 |
Szyf M. Epigenetic therapeutics in autoimmune disease. Clinical Reviews in Allergy & Immunology. 39: 62-77. PMID 19644776 DOI: 10.1007/S12016-009-8172-8 |
0.532 |
|
| 2010 |
Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Current Oncology (Toronto, Ont.). 15: 72-5. PMID 18454186 DOI: 10.3747/Co.V15I2.210 |
0.621 |
|
| 2010 |
Alvarado SG, Andrews SD, Chik F, Szyf M. Abstract 172: A role for the demethylation of microRNA-496 in MBD2-mediated repression Cancer Research. 70: 172-172. DOI: 10.1158/1538-7445.Am10-172 |
0.424 |
|
| 2010 |
Stefanska B, Bhattacharyya B, Han ZG, Huang J, Suderman M, Hallett M, Rabbani SA, Szyf M. Abstract 158: The landscape of DNA hypomethylation in liver cancer, its correlation with other cancers, and its potential role in cancer Cancer Research. 70: 158-158. DOI: 10.1158/1538-7445.Am10-158 |
0.43 |
|
| 2009 |
Unterberger A, Szyf M, Nathanielsz PW, Cox LA. Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons. Journal of Medical Primatology. 38: 219-27. PMID 19602098 DOI: 10.1111/J.1600-0684.2008.00320.X |
0.407 |
|
| 2009 |
Csoka AB, Szyf M. Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Medical Hypotheses. 73: 770-80. PMID 19501473 DOI: 10.1016/J.Mehy.2008.10.039 |
0.509 |
|
| 2009 |
Szyf M. The early life environment and the epigenome. Biochimica Et Biophysica Acta. 1790: 878-85. PMID 19364482 DOI: 10.1016/J.Bbagen.2009.01.009 |
0.363 |
|
| 2009 |
McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience. 12: 342-8. PMID 19234457 DOI: 10.1038/Nn.2270 |
0.387 |
|
| 2009 |
Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, Ernst N, Quirion R, Gratton A, Szyf M, Turecki G. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Archives of General Psychiatry. 66: 22-32. PMID 19124685 DOI: 10.1001/Archpsyc.66.1.22 |
0.355 |
|
| 2009 |
Szyf M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annual Review of Pharmacology and Toxicology. 49: 243-63. PMID 18851683 DOI: 10.1146/Annurev-Pharmtox-061008-103102 |
0.517 |
|
| 2008 |
Szyf M, Meaney MJ. Epigenetics, behaviour, and health. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology. 4: 37-49. PMID 20525124 DOI: 10.1186/1710-1492-4-1-37 |
0.402 |
|
| 2008 |
Unterberger A, Torrisani J, Szyf M. A method for purification, identification and validation of DNMT1 mRNA binding proteins. Biological Procedures Online. 10: 47-57. PMID 19048127 DOI: 10.1251/Bpo142 |
0.368 |
|
| 2008 |
Patra SK, Szyf M. DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A. The Febs Journal. 275: 5217-35. PMID 18803665 DOI: 10.1111/J.1742-4658.2008.06658.X |
0.593 |
|
| 2008 |
McGowan PO, Meaney MJ, Szyf M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Research. 1237: 12-24. PMID 18694740 DOI: 10.1016/J.Brainres.2008.07.074 |
0.516 |
|
| 2008 |
Ernst C, McGowan PO, Deleva V, Meaney MJ, Szyf M, Turecki G. The effects of pH on DNA methylation state: In vitro and post-mortem brain studies. Journal of Neuroscience Methods. 174: 123-5. PMID 18656499 DOI: 10.1016/J.Jneumeth.2008.06.027 |
0.533 |
|
| 2008 |
Poulter MO, Du L, Weaver IC, Palkovits M, Faludi G, Merali Z, Szyf M, Anisman H. GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biological Psychiatry. 64: 645-52. PMID 18639864 DOI: 10.1016/J.Biopsych.2008.05.028 |
0.399 |
|
| 2008 |
Brown SE, Suderman MJ, Hallett M, Szyf M. DNA demethylation induced by the methyl-CpG-binding domain protein MBD3. Gene. 420: 99-106. PMID 18602768 DOI: 10.1016/J.Gene.2008.05.009 |
0.627 |
|
| 2008 |
Brown SE, Weaver IC, Meaney MJ, Szyf M. Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus. Neuroscience Letters. 440: 49-53. PMID 18539393 DOI: 10.1016/J.Neulet.2008.05.028 |
0.574 |
|
| 2008 |
Cameron NM, Shahrokh D, Del Corpo A, Dhir SK, Szyf M, Champagne FA, Meaney MJ. Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. Journal of Neuroendocrinology. 20: 795-801. PMID 18513204 DOI: 10.1111/J.1365-2826.2008.01725.X |
0.32 |
|
| 2008 |
McGowan PO, Sasaki A, Huang TC, Unterberger A, Suderman M, Ernst C, Meaney MJ, Turecki G, Szyf M. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. Plos One. 3: e2085. PMID 18461137 DOI: 10.1371/Journal.Pone.0002085 |
0.439 |
|
| 2008 |
Ateeq B, Unterberger A, Szyf M, Rabbani SA. Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia (New York, N.Y.). 10: 266-78. PMID 18320071 DOI: 10.1593/Neo.07947 |
0.45 |
|
| 2008 |
Brown SE, Szyf M. Dynamic epigenetic states of ribosomal RNA promoters during the cell cycle. Cell Cycle (Georgetown, Tex.). 7: 382-90. PMID 18235221 DOI: 10.4161/Cc.7.3.5283 |
0.47 |
|
| 2008 |
Hamm S, Just G, Lacoste N, Moitessier N, Szyf M, Mamer O. On the mechanism of demethylation of 5-methylcytosine in DNA. Bioorganic & Medicinal Chemistry Letters. 18: 1046-9. PMID 18162397 DOI: 10.1016/J.Bmcl.2007.12.027 |
0.573 |
|
| 2008 |
Szyf M, McGowan P, Meaney MJ. The social environment and the epigenome. Environmental and Molecular Mutagenesis. 49: 46-60. PMID 18095330 DOI: 10.1002/Em.20357 |
0.487 |
|
| 2008 |
Choi AO, Brown SE, Szyf M, Maysinger D. Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. Journal of Molecular Medicine (Berlin, Germany). 86: 291-302. PMID 17965848 DOI: 10.1007/S00109-007-0274-2 |
0.335 |
|
| 2007 |
Brown SE, Fraga MF, Weaver IC, Berdasco M, Szyf M. Variations in DNA methylation patterns during the cell cycle of HeLa cells. Epigenetics. 2: 54-65. PMID 17965591 DOI: 10.4161/Epi.2.1.3880 |
0.603 |
|
| 2007 |
D'Alessio AC, Weaver IC, Szyf M. Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. Molecular and Cellular Biology. 27: 7462-74. PMID 17709385 DOI: 10.1128/Mcb.01120-07 |
0.551 |
|
| 2007 |
Szyf M. The dynamic epigenome and its implications in toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 7-23. PMID 17675334 DOI: 10.1093/Toxsci/Kfm177 |
0.45 |
|
| 2007 |
Arvanitis DN, Ducatenzeiler A, Ou JN, Grodstein E, Andrews SD, Tendulkar SR, Ribeiro-da-Silva A, Szyf M, Cuello AC. High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB. Journal of Neurochemistry. 103: 216-28. PMID 17587310 DOI: 10.1111/J.1471-4159.2007.04704.X |
0.302 |
|
| 2007 |
Szyf M, Weaver I, Meaney M. Maternal care, the epigenome and phenotypic differences in behavior. Reproductive Toxicology (Elmsford, N.Y.). 24: 9-19. PMID 17561370 DOI: 10.1016/J.Reprotox.2007.05.001 |
0.438 |
|
| 2007 |
Brown SE, Szyf M. Epigenetic programming of the rRNA promoter by MBD3. Molecular and Cellular Biology. 27: 4938-52. PMID 17452452 DOI: 10.1128/Mcb.02037-07 |
0.477 |
|
| 2007 |
Weaver IC, D'Alessio AC, Brown SE, Hellstrom IC, Dymov S, Sharma S, Szyf M, Meaney MJ. The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1756-68. PMID 17301183 DOI: 10.1523/Jneurosci.4164-06.2007 |
0.539 |
|
| 2007 |
Ou JN, Torrisani J, Unterberger A, Provençal N, Shikimi K, Karimi M, Ekström TJ, Szyf M. Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. Biochemical Pharmacology. 73: 1297-307. PMID 17276411 DOI: 10.1016/J.Bcp.2006.12.032 |
0.611 |
|
| 2007 |
D'Alessio AC, Szyf M. Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 84: 463-76. PMID 16936820 DOI: 10.1139/O06-090 |
0.572 |
|
| 2007 |
Cox L, Unterberger A, Szyf M, Nathanielsz P. 2C-6 Global DNA methylation (GM) and response to moderate maternal nutrient restriction (MNR) in the fetal baboon are tissue and stage of gestation specific Early Human Development. 83: S56. DOI: 10.1016/S0378-3782(07)70083-X |
0.477 |
|
| 2007 |
Meaney MJ, Weaver ICG, Wu T, Hellstrom I, Diorio J, Szyf M. Maternal programming of glucocorticoid receptor expression and HPA responses to stress through DNA methylation in the rat Handbook of Neurochemistry and Molecular Neurobiology: Behavioral Neurochemistry, Neuroendocrinology and Molecular Neurobiology. 595-617. DOI: 10.1007/978-0-387-30405-2_15 |
0.358 |
|
| 2006 |
Torrisani J, Unterberger A, Tendulkar SR, Shikimi K, Szyf M. AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability. Molecular and Cellular Biology. 27: 395-410. PMID 17030625 DOI: 10.1128/Mcb.01236-06 |
0.571 |
|
| 2006 |
Unterberger A, Andrews SD, Weaver IC, Szyf M. DNA methyltransferase 1 knockdown activates a replication stress checkpoint. Molecular and Cellular Biology. 26: 7575-86. PMID 17015478 DOI: 10.1128/Mcb.01887-05 |
0.569 |
|
| 2006 |
Milutinovic S, D'Alessio AC, Detich N, Szyf M. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Carcinogenesis. 28: 560-71. PMID 17012225 DOI: 10.1093/Carcin/Bgl167 |
0.598 |
|
| 2006 |
Shukeir N, Pakneshan P, Chen G, Szyf M, Rabbani SA. Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo. Cancer Research. 66: 9202-10. PMID 16982764 DOI: 10.1158/0008-5472.Can-06-1954 |
0.458 |
|
| 2006 |
Szyf M. Targeting DNA methylation in cancer. Bulletin Du Cancer. 93: 961-72. PMID 16980240 |
0.49 |
|
| 2006 |
Szyf M. Therapeutic implications of DNA methylation. Future Oncology (London, England). 1: 125-35. PMID 16555982 DOI: 10.1517/14796694.1.1.125 |
0.615 |
|
| 2006 |
Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf M, Meaney MJ. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology. 147: 2909-15. PMID 16513834 DOI: 10.1210/En.2005-1119 |
0.385 |
|
| 2006 |
Weaver IC, Meaney MJ, Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proceedings of the National Academy of Sciences of the United States of America. 103: 3480-5. PMID 16484373 DOI: 10.1073/Pnas.0507526103 |
0.352 |
|
| 2005 |
Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11045-54. PMID 16306417 DOI: 10.1523/Jneurosci.3652-05.2005 |
0.441 |
|
| 2005 |
Pakneshan P, Szyf M, Rabbani SA. Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications. Current Cancer Drug Targets. 5: 471-88. PMID 16305345 DOI: 10.2174/156800905774574011 |
0.415 |
|
| 2005 |
Szyf M, Weaver IC, Champagne FA, Diorio J, Meaney MJ. Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Frontiers in Neuroendocrinology. 26: 139-62. PMID 16303171 DOI: 10.1016/J.Yfrne.2005.10.002 |
0.519 |
|
| 2005 |
Meaney MJ, Szyf M. Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience. 7: 103-23. PMID 16262207 |
0.433 |
|
| 2005 |
Meaney MJ, Szyf M. Maternal care as a model for experience-dependent chromatin plasticity? Trends in Neurosciences. 28: 456-63. PMID 16054244 DOI: 10.1016/J.Tins.2005.07.006 |
0.305 |
|
| 2005 |
Szyf M. DNA methylation and demethylation as targets for anticancer therapy. Biochemistry. Biokhimiia. 70: 533-49. PMID 15948707 DOI: 10.1007/S10541-005-0147-7 |
0.532 |
|
| 2005 |
Pakneshan P, Szyf M, Rabbani SA. Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells. Carcinogenesis. 26: 557-64. PMID 15618232 DOI: 10.1093/Carcin/Bgi009 |
0.485 |
|
| 2004 |
Fish EW, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M, Meaney MJ. Epigenetic programming of stress responses through variations in maternal care. Annals of the New York Academy of Sciences. 1036: 167-80. PMID 15817737 DOI: 10.1196/Annals.1330.011 |
0.359 |
|
| 2004 |
Szyf M, Pakneshan P, Rabbani SA. DNA methylation and breast cancer. Biochemical Pharmacology. 68: 1187-97. PMID 15313416 DOI: 10.1016/J.Bcp.2004.04.030 |
0.575 |
|
| 2004 |
Weaver IC, Diorio J, Seckl JR, Szyf M, Meaney MJ. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Annals of the New York Academy of Sciences. 1024: 182-212. PMID 15265782 DOI: 10.1196/Annals.1321.099 |
0.344 |
|
| 2004 |
Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nature Neuroscience. 7: 847-54. PMID 15220929 DOI: 10.1038/Nn1276 |
0.827 |
|
| 2004 |
Szyf M, Pakneshan P, Rabbani SA. DNA demethylation and cancer: therapeutic implications. Cancer Letters. 211: 133-43. PMID 15219937 DOI: 10.1016/J.Canlet.2004.04.009 |
0.607 |
|
| 2004 |
Pakneshan P, Szyf M, Farias-Eisner R, Rabbani SA. Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis. The Journal of Biological Chemistry. 279: 31735-44. PMID 15150277 DOI: 10.1074/Jbc.M401669200 |
0.348 |
|
| 2004 |
Milutinovic S, Brown SE, Zhuang Q, Szyf M. DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. The Journal of Biological Chemistry. 279: 27915-27. PMID 15087453 DOI: 10.1074/Jbc.M312823200 |
0.623 |
|
| 2004 |
Szyf M. DNA methylation and cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 6: 341-53. PMID 14744498 DOI: 10.1016/j.drup.2003.10.002 |
0.554 |
|
| 2004 |
Ivanov MA, Lamrihi B, Szyf M, Scherman D, Bigey P. Enhanced antitumor activity of a combination of MBD2-antisense electrotransfer gene therapy and bleomycin electrochemotherapy. The Journal of Gene Medicine. 5: 893-899. PMID 14533198 DOI: 10.1002/Jgm.438 |
0.501 |
|
| 2004 |
Szyf M. Targeting DNA methylation in cancer. Ageing Research Reviews. 2: 299-328. PMID 12726777 DOI: 10.1016/S1568-1637(03)00012-6 |
0.629 |
|
| 2003 |
Campbell PM, Bovenzi V, Szyf M. Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo. Carcinogenesis. 25: 499-507. PMID 14688029 DOI: 10.1093/Carcin/Bgh045 |
0.429 |
|
| 2003 |
Detich N, Bovenzi V, Szyf M. Valproate induces replication-independent active DNA demethylation. The Journal of Biological Chemistry. 278: 27586-92. PMID 12748177 DOI: 10.1074/Jbc.M303740200 |
0.629 |
|
| 2003 |
Detich N, Hamm S, Just G, Knox JD, Szyf M. The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. The Journal of Biological Chemistry. 278: 20812-20. PMID 12676953 DOI: 10.1074/Jbc.M211813200 |
0.566 |
|
| 2003 |
Milutinovic S, Zhuang Q, Niveleau A, Szyf M. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes Journal of Biological Chemistry. 278: 14985-14995. PMID 12576480 DOI: 10.1074/Jbc.M213219200 |
0.572 |
|
| 2003 |
Campbell PM, Szyf M. Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. Carcinogenesis. 24: 17-24. PMID 12538344 DOI: 10.1093/Carcin/24.1.17 |
0.477 |
|
| 2003 |
Szyf M. Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis. Methods (San Diego, Calif.). 27: 184-91. PMID 12095279 DOI: 10.1016/S1046-2023(02)00073-7 |
0.516 |
|
| 2002 |
Weaver IC, Szyf M, Meaney MJ. From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocrine Research. 28: 699. PMID 12530685 DOI: 10.1081/Erc-120016989 |
0.47 |
|
| 2002 |
Guo Y, Pakneshan P, Gladu J, Slack A, Szyf M, Rabbani SA. Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. The Journal of Biological Chemistry. 277: 41571-9. PMID 12198113 DOI: 10.1074/Jbc.M201864200 |
0.78 |
|
| 2002 |
Detich N, Theberge J, Szyf M. Promoter-specific activation and demethylation by MBD2/demethylase. The Journal of Biological Chemistry. 277: 35791-4. PMID 12177048 DOI: 10.1074/Jbc.C200408200 |
0.488 |
|
| 2002 |
Slack A, Bovenzi V, Bigey P, Ivanov MA, Ramchandani S, Bhattacharya S, tenOever B, Lamrihi B, Scherman D, Szyf M. Antisense MBD2 gene therapy inhibits tumorigenesis Journal of Gene Medicine. 4: 381-389. PMID 12124980 DOI: 10.1002/Jgm.288 |
0.855 |
|
| 2002 |
Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M. The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. The Journal of Biological Chemistry. 277: 25026-31. PMID 11978794 DOI: 10.1074/Jbc.M202256200 |
0.852 |
|
| 2002 |
Szyf M, Bhattacharya SK. Extracting DNA demethylase activity from mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 200: 163-76. PMID 11951651 DOI: 10.1385/1-59259-182-5:163 |
0.454 |
|
| 2002 |
Szyf M, Bhattacharya SK. Measuring DNA demethylase activity in vitro. Methods in Molecular Biology (Clifton, N.J.). 200: 155-61. PMID 11951650 DOI: 10.1385/1-59259-182-5:155 |
0.466 |
|
| 2002 |
Milutinovic S, Zhuang Q, Szyf M. Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification Journal of Biological Chemistry. 277: 20974-20978. PMID 11929879 DOI: 10.1074/Jbc.M202504200 |
0.532 |
|
| 2002 |
Siedow A, Szyf M, Gratchev A, Kobalz U, Hanski ML, Bumke-Vogt C, Foss HD, Riecken EO, Hanski C. De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 23: 54-60. PMID 11893907 DOI: 10.1159/000048689 |
0.339 |
|
| 2001 |
Weaver IC, La Plante P, Weaver S, Parent A, Sharma S, Diorio J, Chapman KE, Seckl JR, Szyf M, Meaney MJ. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Molecular and Cellular Endocrinology. 185: 205-18. PMID 11738810 DOI: 10.1016/S0303-7207(01)00635-9 |
0.332 |
|
| 2001 |
Hodge DR, Xiao W, Clausen PA, Heidecker G, Szyf M, Farrar WL. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. The Journal of Biological Chemistry. 276: 39508-11. PMID 11551897 DOI: 10.1074/Jbc.C100343200 |
0.344 |
|
| 2001 |
Szyf M, Detich N. Regulation of the DNA methylation machinery and its role in cellular transformation. Progress in Nucleic Acid Research and Molecular Biology. 69: 47-79. PMID 11550798 DOI: 10.1016/S0079-6603(01)69044-5 |
0.649 |
|
| 2001 |
Cervoni N, Szyf M. Demethylase activity is directed by histone acetylation. The Journal of Biological Chemistry. 276: 40778-87. PMID 11524416 DOI: 10.1074/Jbc.M103921200 |
0.826 |
|
| 2001 |
Szyf M. The DNA methylation machinery as a therapeutic target. Current Drug Targets. 1: 101-18. PMID 11475533 DOI: 10.2174/1389450003349362 |
0.564 |
|
| 2001 |
Szyf M. Towards a pharmacology of DNA methylation. Trends in Pharmacological Sciences. 22: 350-4. PMID 11431029 DOI: 10.1016/S0165-6147(00)01713-2 |
0.625 |
|
| 2001 |
Slack A, Pinard M, Araujo FD, Szyf M. A novel regulatory element in the dnmt1 gene that responds to co-activation by Rb and c-Jun Gene. 268: 87-96. PMID 11368904 DOI: 10.1016/S0378-1119(01)00427-9 |
0.684 |
|
| 2001 |
Detich N, Ramchandani S, Szyf M. A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity. The Journal of Biological Chemistry. 276: 24881-90. PMID 11335728 DOI: 10.1074/Jbc.M103056200 |
0.764 |
|
| 2001 |
Szyf M. The role of DNA methyltransferase 1 in growth control. Frontiers in Bioscience : a Journal and Virtual Library. 6: D599-609. PMID 11282571 DOI: 10.2741/Szyf |
0.612 |
|
| 2001 |
Araujo FD, Croteau S, Slack AD, Milutinovic S, Bigey P, Price GB, Zannis-Hadjopoulos M, Zannis-Hajopoulos M, Szyf M. The DNMT1 target recognition domain resides in the N terminus. The Journal of Biological Chemistry. 276: 6930-6. PMID 11104769 DOI: 10.1074/Jbc.M009037200 |
0.73 |
|
| 2001 |
Szyf M. The role of DNA methyltransferase 1 in growth control Frontiers in Bioscience. 6: d599-609. DOI: 10.2741/a630 |
0.342 |
|
| 2000 |
Szyf M, Slack AD. Mechanisms of epigenetic silencing of the c21 gene in Y1 adrenocortical tumor cells. Endocrine Research. 26: 921-30. PMID 11196471 DOI: 10.3109/07435800009048618 |
0.76 |
|
| 2000 |
Szyf M, Knox DJ, Milutinovic S, Slack AD, Araujo FD. How does DNA methyltransferase cause oncogenic transformation? Annals of the New York Academy of Sciences. 910: 156-74; discussion 1. PMID 10911912 DOI: 10.1111/J.1749-6632.2000.Tb06707.X |
0.794 |
|
| 2000 |
Knox JD, Araujo FD, Bigey P, Slack AD, Price GB, Zannis-Hadjopoulos M, Szyf M. Inhibition of DNA methyltransferase inhibits DNA replication. The Journal of Biological Chemistry. 275: 17986-90. PMID 10849434 DOI: 10.1074/Jbc.C900894199 |
0.79 |
|
| 2000 |
Bigey P, Ramchandani S, Theberge J, Araujo FD, Szyf M. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene. 242: 407-18. PMID 10721735 DOI: 10.1016/S0378-1119(99)00501-6 |
0.797 |
|
| 2000 |
Milutinovic S, Knox JD, Szyf M. DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1). The Journal of Biological Chemistry. 275: 6353-9. PMID 10692435 DOI: 10.1074/Jbc.275.9.6353 |
0.521 |
|
| 1999 |
Slack A, Cervoni N, Pinard M, Szyf M. Feedback regulation of DNA methyltransferase gene expression by methylation. European Journal of Biochemistry / Febs. 264: 191-9. PMID 10447688 DOI: 10.1046/J.1432-1327.1999.00603.X |
0.85 |
|
| 1999 |
Deng J, Szyf M. Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation. Brain Research. Molecular Brain Research. 71: 23-31. PMID 10407183 DOI: 10.1016/S0169-328X(99)00147-3 |
0.573 |
|
| 1999 |
Ramchandani S, Bhattacharya SK, Cervoni N, Szyf M. DNA methylation is a reversible biological signal. Proceedings of the National Academy of Sciences of the United States of America. 96: 6107-12. PMID 10339549 DOI: 10.1073/Pnas.96.11.6107 |
0.845 |
|
| 1999 |
Slack A, Cervoni N, Pinard M, Szyf M. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. The Journal of Biological Chemistry. 274: 10105-12. PMID 10187792 DOI: 10.1074/Jbc.274.15.10105 |
0.811 |
|
| 1999 |
Araujo FD, Knox JD, Ramchandani S, Pelletier R, Bigey P, Price G, Szyf M, Zannis-Hadjopoulos M. Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus. The Journal of Biological Chemistry. 274: 9335-41. PMID 10092611 DOI: 10.1074/Jbc.274.14.9335 |
0.822 |
|
| 1999 |
Cervoni N, Bhattacharya S, Szyf M. DNA demethylase is a processive enzyme. The Journal of Biological Chemistry. 274: 8363-6. PMID 10085064 DOI: 10.1074/Jbc.274.13.8363 |
0.821 |
|
| 1999 |
Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature. 397: 579-83. PMID 10050851 DOI: 10.1038/17533 |
0.847 |
|
| 1999 |
Bigey P, Knox JD, Croteau S, Bhattacharya SK, Théberge J, Szyf M. Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase. The Journal of Biological Chemistry. 274: 4594-606. PMID 9988694 DOI: 10.1074/Jbc.274.8.4594 |
0.537 |
|
| 1999 |
Araujo FD, Knox JD, Szyf M, Price GB, Zannis-Hadjopoulos M. Concurrent Replication and Methylation at Mammalian Origins of Replication Molecular and Cellular Biology. 19: 4546-4546. DOI: 10.1128/mcb.19.6.4546 |
0.378 |
|
| 1998 |
Szyf M. Targeting DNA methyltransferase in cancer. Cancer Metastasis Reviews. 17: 219-31. PMID 9770119 DOI: 10.1023/A:1006023023787 |
0.583 |
|
| 1998 |
Deng J, Szyf M. Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene. The Journal of Biological Chemistry. 273: 22869-72. PMID 9722504 DOI: 10.1074/Jbc.273.36.22869 |
0.614 |
|
| 1998 |
Ramchandani S, Bigey P, Szyf M. Genomic structure of the human DNA methyltransferase gene. Biological Chemistry. 379: 535-40. PMID 9628348 |
0.799 |
|
| 1998 |
Araujo FD, Knox JD, Szyf M, Price GB, Zannis-Hadjopoulos M. Concurrent replication and methylation at mammalian origins of replication Molecular and Cellular Biology. 18: 3475-3482. PMID 9584187 DOI: 10.1128/Mcb.18.6.3475 |
0.611 |
|
| 1997 |
Ramchandani S, MacLeod AR, Pinard M, von Hofe E, Szyf M. Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proceedings of the National Academy of Sciences of the United States of America. 94: 684-9. PMID 9012845 DOI: 10.1073/Pnas.94.2.684 |
0.823 |
|
| 1996 |
Szyf M. The DNA methylation machinery as a target for anticancer therapy. Pharmacology & Therapeutics. 70: 1-37. PMID 8804109 DOI: 10.1016/0163-7258(96)00002-2 |
0.614 |
|
| 1995 |
Rouleau J, MacLeod AR, Szyf M. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. The Journal of Biological Chemistry. 270: 1595-601. PMID 7829490 DOI: 10.1074/jbc.270.4.1595 |
0.445 |
|
| 1995 |
Szyf M, Theberge J, Bozovic V. Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. The Journal of Biological Chemistry. 270: 12690-6. PMID 7759521 DOI: 10.1074/Jbc.270.21.12690 |
0.478 |
|
| 1995 |
MacLeod AR, Rouleau J, Szyf M. Regulation of DNA methylation by the Ras signaling pathway. The Journal of Biological Chemistry. 270: 11327-37. PMID 7744770 DOI: 10.1074/Jbc.270.19.11327 |
0.555 |
|
| 1995 |
MacLeod AR, Szyf M. Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. The Journal of Biological Chemistry. 270: 8037-43. PMID 7713905 DOI: 10.1074/Jbc.270.14.8037 |
0.499 |
|
| 1994 |
Szyf M. DNA methylation properties: consequences for pharmacology. Trends in Pharmacological Sciences. 15: 233-8. PMID 7940985 DOI: 10.1016/0165-6147(94)90317-4 |
0.631 |
|
| 1992 |
Szyf M. DNA methylation patterns: an additional level of information? Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 69: 764-7. PMID 1818583 DOI: 10.1139/O91-117 |
0.601 |
|
| 1990 |
Szyf M, Tanigawa G, McCarthy PL. A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. Molecular and Cellular Biology. 10: 4396-400. PMID 1973527 DOI: 10.1128/MCB.10.8.4396 |
0.49 |
|
| 1989 |
Szyf M, Schimmer BP, Seidman JG. Nucleotide-sequence-specific de novo methylation in a somatic murine cell line. Proceedings of the National Academy of Sciences of the United States of America. 86: 6853-7. PMID 2789380 DOI: 10.1073/Pnas.86.18.6853 |
0.445 |
|
| 1986 |
Szyf M, Meisels E, Razin A. Biological role of DNA methylation: sequence-specific single-strand breaks associated with hypomethylation of GATC sites in Escherichia coli DNA. Journal of Bacteriology. 168: 1487-90. PMID 3536887 DOI: 10.1128/jb.168.3.1487-1490.1986 |
0.429 |
|
| 1986 |
Kohen R, Szyf M, Chevion M. Quantitation of single- and double-strand DNA breaks in vitro and in vivo. Analytical Biochemistry. 154: 485-91. PMID 3524311 DOI: 10.1016/0003-2697(86)90019-9 |
0.415 |
|
| 1986 |
Razin A, Szyf M, Kafri T, Roll M, Giloh H, Scarpa S, Carotti D, Cantoni GL. Replacement of 5-methylcytosine by cytosine: A possible mechanism for transient DNA demethylation during differentiation Proceedings of the National Academy of Sciences of the United States of America. 83: 2827-2831. PMID 3458243 DOI: 10.1073/Pnas.83.9.2827 |
0.501 |
|
| 1985 |
Nur I, Szyf M, Razin A, Glaser G, Rottem S, Razin S. Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). Journal of Bacteriology. 164: 19-24. PMID 4044519 DOI: 10.1128/jb.164.1.19-24.1985 |
0.48 |
|
| 1985 |
Szyf M, Eliasson L, Mann V, Klein G, Razin A. Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle. Proceedings of the National Academy of Sciences of the United States of America. 82: 8090-4. PMID 2999791 DOI: 10.1073/Pnas.82.23.8090 |
0.543 |
|
| 1985 |
Benvenisty N, Szyf M, Mencher D, Razin A, Reshef L. Tissue-specific hypomethylation and expression of rat phosphoenolpyruvate carboxykinase gene induced by in vivo treatment of fetuses and neonates with 5-azacytidine Biochemistry. 24: 5015-5019. PMID 2416339 DOI: 10.1021/Bi00340A009 |
0.455 |
|
| 1984 |
Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, Naveh-Many T, Sciaky-Gallili N, Cedar H. Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America. 81: 2275-9. PMID 6585800 DOI: 10.1073/Pnas.81.8.2275 |
0.601 |
|
| 1984 |
Razin A, Szyf M. DNA methylation patterns. Formation and function. Biochimica Et Biophysica Acta. 782: 331-42. PMID 6383476 DOI: 10.1016/0167-4781(84)90043-5 |
0.564 |
|
| 1984 |
Pollack Y, Kasir J, Shemer R, Metzger S, Szyf M. Methylation pattern of mouse mitochondrial DNA. Nucleic Acids Research. 12: 4811-24. PMID 6330684 DOI: 10.1093/Nar/12.12.4811 |
0.563 |
|
| 1984 |
Szyf M, Avraham-Haetzni K, Reifman A, Shlomai J, Kaplan F, Oppenheim A, Razin A. DNA methylation pattern is determined by the intracellular level of the methylase. Proceedings of the National Academy of Sciences of the United States of America. 81: 3278-82. PMID 6233606 DOI: 10.1073/Pnas.81.11.3278 |
0.583 |
|
| 1983 |
Gruenbaum Y, Szyf M, Cedar H, Razin A. Methylation of replicating and post-replicated mouse L-cell DNA. Proceedings of the National Academy of Sciences of the United States of America. 80: 4919-21. PMID 6576364 DOI: 10.1073/Pnas.80.16.4919 |
0.567 |
|
| 1983 |
Szyf M, Gruenbaum Y, Urieli-Shoval S, Razin A. Studies on the biological role of DNA methylation: V. The pattern of E.coli DNA methylation. Nucleic Acids Research. 10: 7247-59. PMID 6296768 DOI: 10.1093/Nar/10.22.7247 |
0.586 |
|
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