Year |
Citation |
Score |
2020 |
Shivshankar P, Li YD, Mueller-Ortiz SL, Wetsel RA. In response to complement anaphylatoxin peptides C3a and C5a, human vascular endothelial cells migrate and mediate the activation of B-cells and polarization of T-cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32301538 DOI: 10.1096/Fj.201902397R |
0.492 |
|
2020 |
Shivshankar P, Fekry B, Eckel-Mahan K, Wetsel RA. Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology? Frontiers in Cellular and Infection Microbiology. 10. DOI: 10.3389/Fcimb.2020.00418 |
0.348 |
|
2019 |
Simmons KT, Mazzilli JL, Mueller-Ortiz SL, Domozhirov AY, Garcia CA, Zsigmond EM, Wetsel RA. Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration. Molecular Immunology. 118: 91-98. PMID 31862673 DOI: 10.1016/J.Molimm.2019.11.007 |
0.305 |
|
2019 |
Tan SM, Ziemann M, Thallas-Bonke V, Snelson M, Kumar V, Laskowski A, Nguyen TV, Huynh K, Clarke MV, Libianto R, Baker ST, Skene A, Power DA, MacIsaac RJ, Henstridge DC, ... Wetsel RA, et al. Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility. Diabetes. PMID 31624141 DOI: 10.2337/Db19-0043 |
0.352 |
|
2019 |
Mueller-Ortiz SL, Shivshankar P, Wetsel RA. The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with . Journal of Immunology (Baltimore, Md. : 1950). PMID 31597707 DOI: 10.4049/Jimmunol.1900314 |
0.418 |
|
2019 |
Muenstermann M, Strobel L, Klos A, Wetsel RA, Woodruff TM, Köhl J, Johswich KO. Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections. Virulence. PMID 31274379 DOI: 10.1080/21505594.2019.1640035 |
0.509 |
|
2018 |
Shivshankar P, Fekry B, Li Y, Eckel-Mahan K, Wetsel R. C5a modulates immune cell egression in lymphoid tissues via endothelial-dependent inducible nitric oxide synthase Molecular Immunology. 102: 214. DOI: 10.1016/J.Molimm.2018.06.213 |
0.384 |
|
2018 |
Shivshankar P, Li Y, Wetsel R. Chronic intradermal C5a exposure stimulates cardiac fibrosis – A role of inflamed lymphatic endothelium Molecular Immunology. 102: 213. DOI: 10.1016/J.Molimm.2018.06.212 |
0.36 |
|
2018 |
Mueller-Ortiz S, Shivshankar P, Wetsel R. The second receptor for C5a, C5aR2, is detrimental to the host during systemic infection with Listeria monocytogenes Molecular Immunology. 102: 191. DOI: 10.1016/J.Molimm.2018.06.161 |
0.416 |
|
2018 |
Muenstermann M, Herrmann J, Strobel L, Woodruff T, Klos A, Wetsel R, Gerard C, Köhl J, Johswich KO. The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease Molecular Immunology. 102: 168-169. DOI: 10.1016/J.Molimm.2018.06.109 |
0.309 |
|
2017 |
Hernandez MX, Jiang S, Cole TA, Chu SH, Fonseca MI, Fang MJ, Hohsfield LA, Torres MD, Green KN, Wetsel RA, Mortazavi A, Tenner AJ. Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss. Molecular Neurodegeneration. 12: 66. PMID 28923083 DOI: 10.1186/S13024-017-0210-Z |
0.389 |
|
2017 |
Mueller-Ortiz SL, Calame DG, Shenoi N, Li YD, Wetsel RA. The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway. Journal of Immunology (Baltimore, Md. : 1950). PMID 28275134 DOI: 10.4049/Jimmunol.1601420 |
0.469 |
|
2016 |
Stokowska A, Atkins AL, Morán J, Pekny T, Bulmer L, Pascoe MC, Barnum SR, Wetsel RA, Nilsson JA, Dragunow M, Pekna M. Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia. Brain : a Journal of Neurology. PMID 27956400 DOI: 10.1093/Brain/Aww314 |
0.478 |
|
2016 |
Kim YU, Kim BS, Lim H, Wetsel RA, Chung Y. Enforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3⁺ T Cells. Biomolecules & Therapeutics. PMID 27737526 DOI: 10.4062/Biomolther.2016.075 |
0.32 |
|
2016 |
Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y. Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. Plos Pathogens. 12: e1005678. PMID 27304426 DOI: 10.1371/Journal.Ppat.1005678 |
0.388 |
|
2016 |
Shivshankar P, Mueller-Ortiz SL, Wetsel RA. In response to C3a/C5a, human vascular endothelial cells transmigrate and mediate the activation of B-cells and polarization of T-cells Immunobiology. 221: 1221-1222. DOI: 10.1016/J.Imbio.2016.06.217 |
0.425 |
|
2016 |
Shivshankar P, Aldrich MB, Sevick-Muraca EM, Wetsel RA. Near-infrared fluorescence optical imaging demonstrates that C5a-C5aR1 signaling impairs normal lymphatic function Immunobiology. 221: 1186-1187. DOI: 10.1016/J.Imbio.2016.06.138 |
0.34 |
|
2015 |
Wang D, Quan Y, Yan Q, Morales JE, Wetsel RA. Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells. Stem Cells Translational Medicine. PMID 26285657 DOI: 10.5966/Sctm.2015-0049 |
0.312 |
|
2015 |
Kim YU, Lim H, Jung HE, Wetsel RA, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. Plos One. 10: e0120294. PMID 25768299 DOI: 10.1371/Journal.Pone.0120294 |
0.377 |
|
2015 |
Nonaka MI, Zsigmond E, Kudo A, Kawakami H, Yoshida K, Yoshida M, Kawano N, Miyado K, Nonaka M, Wetsel RA. Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility. Immunobiology. 220: 467-75. PMID 25468721 DOI: 10.1016/J.Imbio.2014.11.001 |
0.309 |
|
2015 |
Yuan X, Shan M, You R, Frazier MV, Hong MJ, Wetsel RA, Drouin S, Seryshev A, Song LZ, Cornwell L, Rossen RD, Corry DB, Kheradmand F. Activation of C3a receptor is required in cigarette smoke-mediated emphysema. Mucosal Immunology. 8: 874-85. PMID 25465103 DOI: 10.1038/Mi.2014.118 |
0.414 |
|
2014 |
Calame DG, Mueller-Ortiz SL, Morales JE, Wetsel RA. The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression. Journal of Immunology (Baltimore, Md. : 1950). 193: 5099-107. PMID 25297874 DOI: 10.4049/Jimmunol.1401750 |
0.45 |
|
2014 |
Mueller-Ortiz SL, Morales JE, Wetsel RA. The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 193: 1278-89. PMID 24981453 DOI: 10.4049/Jimmunol.1302787 |
0.445 |
|
2014 |
Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, Wetsel RA, Pabst O, Klos A. The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response. The Journal of Infectious Diseases. 209: 1269-78. PMID 24273177 DOI: 10.1093/Infdis/Jit640 |
0.468 |
|
2014 |
Yan Q, Quan Y, Sun H, Peng X, Zou Z, Alcorn JL, Wetsel RA, Wang D. A site-specific genetic modification for induction of pluripotency and subsequent isolation of derived lung alveolar epithelial type II cells. Stem Cells (Dayton, Ohio). 32: 402-13. PMID 24123810 DOI: 10.1002/Stem.1570 |
0.315 |
|
2014 |
Hu X, Wetsel RA, Ramos TN, Mueller-Ortiz SL, Schoeb TR, Barnum SR. Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis. Immunobiology. 219: 104-8. PMID 24028840 DOI: 10.1016/J.Imbio.2013.08.007 |
0.389 |
|
2013 |
Järlestedt K, Rousset CI, Ståhlberg A, Sourkova H, Atkins AL, Thornton C, Barnum SR, Wetsel RA, Dragunow M, Pekny M, Mallard C, Hagberg H, Pekna M. Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3797-804. PMID 23737250 DOI: 10.1096/Fj.13-230011 |
0.521 |
|
2013 |
Wu MC, Brennan FH, Lynch JP, Mantovani S, Phipps S, Wetsel RA, Ruitenberg MJ, Taylor SM, Woodruff TM. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America. 110: 9439-44. PMID 23696668 DOI: 10.1073/Pnas.1218815110 |
0.489 |
|
2013 |
Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A. The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. Plos One. 8: e62257. PMID 23638016 DOI: 10.1371/Journal.Pone.0062257 |
0.541 |
|
2012 |
Lim H, Kim YU, Drouin SM, Mueller-Ortiz S, Yun K, Morschl E, Wetsel RA, Chung Y. Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice. Plos One. 7: e52666. PMID 23285141 DOI: 10.1371/Journal.Pone.0052666 |
0.502 |
|
2012 |
Darley MM, Ramos TN, Wetsel RA, Barnum SR. Deletion of carboxypeptidase N delays onset of experimental cerebral malaria. Parasite Immunology. 34: 444-7. PMID 22708514 DOI: 10.1111/J.1365-3024.2012.01376.X |
0.463 |
|
2012 |
Pavlovski D, Thundyil J, Monk PN, Wetsel RA, Taylor SM, Woodruff TM. Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3680-90. PMID 22651932 DOI: 10.1096/Fj.11-202382 |
0.445 |
|
2012 |
Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 1469-78. PMID 22205026 DOI: 10.4049/Jimmunol.1102310 |
0.521 |
|
2012 |
Mueller-Ortiz SL, Morales JE, Clark A, Wetsel RA. The complement anaphylatoxin C3a is critical in generating both innate and adaptive immune responses to Listeria monocytogenes due to its indispensible role in immune cell survival Immunobiology. 217: 1209. DOI: 10.1016/J.Imbio.2012.08.230 |
0.382 |
|
2012 |
Woodruff TM, Wu MC, Brennan FH, Wetsel RA, Ruitenberg MJ, Taylor SM. The C3a receptor mediates protection from intestinal ischemia reperfusion injuries by impairing neutrophil mobilization Immunobiology. 217: 1209. DOI: 10.1016/J.Imbio.2012.08.229 |
0.416 |
|
2011 |
Mashruwala MA, Smith AK, Lindsey DR, Moczygemba M, Wetsel RA, Klein JR, Actor JK, Jagannath C. A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis. Tuberculosis (Edinburgh, Scotland). 91: S82-9. PMID 22154007 DOI: 10.1016/J.Tube.2011.10.016 |
0.396 |
|
2011 |
Banda N, Hyatt S, Glogowska M, Takahashi K, Merkel T, Stahl G, Lu B, Gerard C, Wetsel R, Arend W, Holers V. Independent roles for complement C3a and C5a receptors and the membrane attack complex in the pathogenesis of collagen antibody-induced arthritis in mice: Potential therapeutic implications Molecular Immunology. 48: 1670. DOI: 10.1016/J.Molimm.2011.06.234 |
0.496 |
|
2010 |
Wang D, Morales JE, Calame DG, Alcorn JL, Wetsel RA. Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 625-34. PMID 20087316 DOI: 10.1038/Mt.2009.317 |
0.314 |
|
2010 |
Mueller-Ortiz SL, Morales JE, Wetsel RA. Mice lacking the C3a receptor (C3aR) are susceptible to Listeria monocytogenes systemic infection despite having an elevated CD4+ Th1 cytokine response Molecular Immunology. 47: 2277-2278. DOI: 10.1016/J.Molimm.2010.05.237 |
0.474 |
|
2009 |
Mueller-Ortiz SL, Wang D, Morales JE, Li L, Chang JY, Wetsel RA. Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. Journal of Immunology (Baltimore, Md. : 1950). 182: 6533-9. PMID 19414808 DOI: 10.4049/Jimmunol.0804207 |
0.523 |
|
2009 |
Markiewski MM, DeAngelis RA, Strey CW, Foukas PG, Gerard C, Gerard N, Wetsel RA, Lambris JD. The regulation of liver cell survival by complement. Journal of Immunology (Baltimore, Md. : 1950). 182: 5412-8. PMID 19380788 DOI: 10.4049/Jimmunol.0804179 |
0.415 |
|
2009 |
Wenderfer SE, Wang H, Ke B, Wetsel RA, Braun MC. C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse. Molecular Immunology. 46: 1397-404. PMID 19167760 DOI: 10.1016/J.Molimm.2008.12.004 |
0.48 |
|
2008 |
Chang JY, Lin CC, Salamanca S, Pangburn MK, Wetsel RA. Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds. Archives of Biochemistry and Biophysics. 480: 104-10. PMID 18854167 DOI: 10.1016/J.Abb.2008.09.013 |
0.419 |
|
2008 |
Hollmann TJ, Mueller-Ortiz SL, Braun MC, Wetsel RA. Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Molecular Immunology. 45: 1907-15. PMID 18063050 DOI: 10.1016/J.Molimm.2007.10.037 |
0.718 |
|
2008 |
Soimo K, Morales J, Ortiz S, Nonaka M, Nonaka M, Blom A, Wetsel R. Generation of C4b binding protein deficient mice: Evaluation of biological functions of C4bBP in vivo Molecular Immunology. 45: 4115. DOI: 10.1016/J.Molimm.2008.08.060 |
0.328 |
|
2008 |
Miwa T, Zhou L, Wetsel R, Song W. Renal ischaemia reperfusion injury in DAF−/−CD59a−/− mice is mediated by properdin and the alternative pathway complement Molecular Immunology. 45: 4111. DOI: 10.1016/J.Molimm.2008.08.048 |
0.321 |
|
2008 |
Sinha M, Drouin S, Woodruff T, Taylor S, Wetsel R. The receptor for complement anaphylatoxin C5a protects against the development of airway hyperresponsiveness in allergic asthma by inhibiting cysteinyl leukotriene pathway Molecular Immunology. 45: 4109-4110. DOI: 10.1016/J.Molimm.2008.08.044 |
0.746 |
|
2008 |
Mueller-Ortiz S, Wang D, Morales J, Li L, Chang J, Wetsel R. Double KO mice deficient in CPN and the anaphylatoxin receptors demonstrate that lethality due to acute complement activation is caused by C5a but not C3a Molecular Immunology. 45: 4108. DOI: 10.1016/J.Molimm.2008.08.040 |
0.531 |
|
2008 |
Wenderfer S, Ke B, Somio K, Wetsel R, Braun M. Mice with combined C4 binding protein and factor H deficiency develop progressive lethal renal disease Molecular Immunology. 45: 4101. DOI: 10.1016/J.Molimm.2008.08.019 |
0.343 |
|
2007 |
Wenderfer SE, Soimo K, Wetsel RA, Braun MC. Analysis of C4 and the C4 binding protein in the MRL/lpr mouse. Arthritis Research & Therapy. 9: R114. PMID 17971229 DOI: 10.1186/Ar2320 |
0.417 |
|
2007 |
Moulton RA, Mashruwala MA, Smith AK, Lindsey DR, Wetsel RA, Haviland DL, Hunter RL, Jagannath C. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. Journal of Leukocyte Biology. 82: 956-67. PMID 17675563 DOI: 10.1189/Jlb.0206119 |
0.436 |
|
2007 |
Kiss A, Montes M, Susarla S, Jaensson EA, Drouin SM, Wetsel RA, Yao Z, Martin R, Hamzeh N, Adelagun R, Amar S, Kheradmand F, Corry DB. A new mechanism regulating the initiation of allergic airway inflammation. The Journal of Allergy and Clinical Immunology. 120: 334-42. PMID 17544098 DOI: 10.1016/J.Jaci.2007.04.025 |
0.316 |
|
2007 |
Dillard P, Wetsel RA, Drouin SM. Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses. American Journal of Respiratory and Critical Care Medicine. 175: 1250-8. PMID 17400733 DOI: 10.1164/Rccm.200701-049Oc |
0.474 |
|
2007 |
Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 110: 228-36. PMID 17363730 DOI: 10.1182/Blood-2006-12-063636 |
0.388 |
|
2007 |
Wang D, Haviland DL, Burns AR, Zsigmond E, Wetsel RA. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4449-54. PMID 17360544 DOI: 10.1073/Pnas.0700052104 |
0.317 |
|
2007 |
Connelly MA, Moulton RA, Smith AK, Lindsey DR, Sinha M, Wetsel RA, Jagannath C. Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells. Journal of Leukocyte Biology. 81: 212-20. PMID 16997854 DOI: 10.1189/Jlb.1005582 |
0.761 |
|
2007 |
Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel R, Miwa T, Song W. Regulation of Toll-like receptor signaling by complement in vivo Molecular Immunology. 44: 263. DOI: 10.1016/J.Molimm.2006.07.272 |
0.314 |
|
2007 |
Wang D, Haviland DL, Zsigmond E, Wetsel RA. Human embryonic stem cell derived alveolar epithelial type II cells express C3 and C5 Molecular Immunology. 44: 255. DOI: 10.1016/J.Molimm.2006.07.253 |
0.302 |
|
2007 |
Mueller-Ortiz SL, Wang D, Morales JE, Wetsel RA. Targeted disruption of the carboxypeptidase N (CPN1) gene generates mice with elevated inflammation in models of pneumonia and peritonitis Molecular Immunology. 44: 217. DOI: 10.1016/J.Molimm.2006.07.165 |
0.336 |
|
2007 |
Ke B, Verani R, Navarro P, Pickering M, Wenderfer S, Wetsel RA, Braun MC. A reciprocal role for the C3a and C5a receptors in glomerular injury in the factor H deficient mouse Molecular Immunology. 44: 193. DOI: 10.1016/J.Molimm.2006.07.109 |
0.48 |
|
2007 |
Fang C, Miwa T, Wetsel R, shen H, Song W. Enhanced CD8+ T cell response to lymphocytic choriomeningitis virus (LCMV) infection in decay-accelerating factor (DAF)-deficient mice Molecular Immunology. 44: 167. DOI: 10.1016/J.Molimm.2006.07.050 |
0.333 |
|
2007 |
Dillard P, Wetsel RA, Drouin SM. The complement anaphylatoxin C3a regulates Muc5ac expression by airway epithelial Clara cells independently of TH2 responses Molecular Immunology. 44: 163-164. DOI: 10.1016/J.Molimm.2006.07.043 |
0.458 |
|
2006 |
Nelson KC, Zhao M, Schroeder PR, Li N, Wetsel RA, Diaz LA, Liu Z. Role of different pathways of the complement cascade in experimental bullous pemphigoid. The Journal of Clinical Investigation. 116: 2892-900. PMID 17024247 DOI: 10.1172/Jci17891 |
0.414 |
|
2006 |
Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. Generation of C5a in the absence of C3: a new complement activation pathway. Nature Medicine. 12: 682-7. PMID 16715088 DOI: 10.1038/Nm1419 |
0.479 |
|
2006 |
Rahpeymai Y, Hietala MA, Wilhelmsson U, Fotheringham A, Davies I, Nilsson AK, Zwirner J, Wetsel RA, Gerard C, Pekny M, Pekna M. Complement: a novel factor in basal and ischemia-induced neurogenesis. The Embo Journal. 25: 1364-74. PMID 16498410 DOI: 10.1038/Sj.Emboj.7601004 |
0.548 |
|
2006 |
Mueller-Ortiz SL, Hollmann TJ, Haviland DL, Wetsel RA. Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L157-65. PMID 16461429 DOI: 10.1152/Ajplung.00358.2005 |
0.697 |
|
2006 |
Drouin SM, Sinha M, Sfyroera G, Lambris JD, Wetsel RA. A protective role for the fifth complement component (c5) in allergic airway disease. American Journal of Respiratory and Critical Care Medicine. 173: 852-7. PMID 16439722 DOI: 10.1164/Rccm.200503-334Oc |
0.769 |
|
2005 |
Wenderfer SE, Ke B, Hollmann TJ, Wetsel RA, Lan HY, Braun MC. C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice. Journal of the American Society of Nephrology : Jasn. 16: 3572-82. PMID 16207826 DOI: 10.1681/Asn.2005040373 |
0.681 |
|
2005 |
Borders CW, Courtney A, Ronen K, Pilar Laborde-Lahoz M, Guidry TV, Hwang SA, Olsen M, Hunter RL, Hollmann TJ, Wetsel RA, Actor JK. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Scandinavian Journal of Immunology. 62: 123-30. PMID 16101818 DOI: 10.1111/J.1365-3083.2005.01643.X |
0.685 |
|
2004 |
Boos L, Campbell IL, Ames R, Wetsel RA, Barnum SR. Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 173: 4708-14. PMID 15383607 DOI: 10.4049/Jimmunol.173.7.4708 |
0.523 |
|
2004 |
Lee LY, Höök M, Haviland D, Wetsel RA, Yonter EO, Syribeys P, Vernachio J, Brown EL. Inhibition of complement activation by a secreted Staphylococcus aureus protein. The Journal of Infectious Diseases. 190: 571-9. PMID 15243934 DOI: 10.1086/422259 |
0.331 |
|
2004 |
Riedemann NC, Guo RF, Gao H, Sun L, Hoesel M, Hollmann TJ, Wetsel RA, Zetoune FS, Ward PA. Regulatory role of C5a on macrophage migration inhibitory factor release from neutrophils. Journal of Immunology (Baltimore, Md. : 1950). 173: 1355-9. PMID 15240730 DOI: 10.4049/Jimmunol.173.2.1355 |
0.695 |
|
2004 |
Markiewski MM, Mastellos D, Tudoran R, DeAngelis RA, Strey CW, Franchini S, Wetsel RA, Erdei A, Lambris JD. C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. Journal of Immunology (Baltimore, Md. : 1950). 173: 747-54. PMID 15240660 DOI: 10.4049/Jimmunol.173.2.747 |
0.493 |
|
2004 |
Matthews KW, Drouin SM, Liu C, Martin JF, Skidgel RA, Wetsel RA. Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development. Developmental and Comparative Immunology. 28: 647-55. PMID 15177117 DOI: 10.1016/J.Dci.2003.10.005 |
0.31 |
|
2004 |
Mueller-Ortiz SL, Drouin SM, Wetsel RA. The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia. Infection and Immunity. 72: 2899-906. PMID 15102802 DOI: 10.1128/Iai.72.5.2899-2906.2004 |
0.425 |
|
2004 |
Riedemann NC, Guo RF, Hollmann TJ, Gao H, Neff TA, Reuben JS, Speyer CL, Sarma JV, Wetsel RA, Zetoune FS, Ward PA. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 370-2. PMID 14688199 DOI: 10.1096/Fj.03-0708Fje |
0.664 |
|
2004 |
Ratajczak J, Reca R, Kucia M, Majka M, Allendorf DJ, Baran JT, Janowska-Wieczorek A, Wetsel RA, Ross GD, Ratajczak MZ. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood. 103: 2071-8. PMID 14604969 DOI: 10.1182/Blood-2003-06-2099 |
0.502 |
|
2004 |
Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Erratum: Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome (Journal of Clinical Investigation (2003) 112 (1644-1654) doi:10.1172/JCI200318817) Journal of Clinical Investigation. 113. DOI: 10.1172/Jci200418817C1 |
0.664 |
|
2004 |
Riedemann NC, Guo R, Hollman T, Wetsel RA, Ward PA. REGULATION OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) PRODUCTION DURING SEPSIS BY C5a Shock. 21: 26. DOI: 10.1097/00024382-200403001-00103 |
0.416 |
|
2003 |
Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. The Journal of Clinical Investigation. 112: 1644-54. PMID 14660741 DOI: 10.1172/Jci18817 |
0.677 |
|
2003 |
Lawrenz MB, Wooten RM, Zachary JF, Drouin SM, Weis JJ, Wetsel RA, Norris SJ. Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice. Infection and Immunity. 71: 4432-40. PMID 12874322 DOI: 10.1128/Iai.71.8.4432-4440.2003 |
0.394 |
|
2002 |
Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. Journal of Immunology (Baltimore, Md. : 1950). 169: 5926-33. PMID 12421977 DOI: 10.4049/Jimmunol.169.10.5926 |
0.445 |
|
2001 |
Drouin SM, Corry DB, Kildsgaard J, Wetsel RA. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. Journal of Immunology (Baltimore, Md. : 1950). 167: 4141-5. PMID 11591733 DOI: 10.4049/Jimmunol.167.8.4141 |
0.413 |
|
2001 |
Actor JK, Breij E, Wetsel RA, Hoffmann H, Hunter RL, Jagannath C. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis. Scandinavian Journal of Immunology. 53: 464-74. PMID 11309154 DOI: 10.1046/J.1365-3083.2001.00902.X |
0.401 |
|
2001 |
Drouin SM, Kildsgaard J, Haviland J, Zabner J, Jia HP, McCray P.B. J, Tack BF, Wetsel RA. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma Journal of Immunology. 166: 2025-2032. PMID 11160252 DOI: 10.4049/Jimmunol.166.3.2025 |
0.467 |
|
2000 |
Nataf S, Carroll SL, Wetsel RA, Szalai AJ, Barnum SR. Attenuation of experimental autoimmune demyelination in complement-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 5867-73. PMID 11067947 DOI: 10.4049/Jimmunol.165.10.5867 |
0.415 |
|
2000 |
Kildsgaard J, Hollmann TJ, Matthews KW, Bian K, Murad F, Wetsel RA. Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock Journal of Immunology. 165: 5406-5409. PMID 11067891 DOI: 10.4049/Jimmunol.165.10.5406 |
0.707 |
|
2000 |
Jagannath C, Hoffmann H, Sepulveda E, Actor JK, Wetsel RA, Hunter RL. Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5). Scandinavian Journal of Immunology. 52: 369-79. PMID 11013008 DOI: 10.1046/J.1365-3083.2000.00770.X |
0.408 |
|
2000 |
Zahedi R, Braun M, Wetsel RA, Ault BH, Khan A, Welch TR, Frenzke M, Davis AE. The C5a receptor is expressed by human renal proximal tubular epithelial cells. Clinical and Experimental Immunology. 121: 226-33. PMID 10931135 DOI: 10.1046/J.1365-2249.2000.01249.X |
0.447 |
|
2000 |
Kildsgaard J, Zsigmond E, Chan L, Wetsel RA. A critical evaluation of the putative role of C3adesArg (ASP) in lipid metabolism and hyperapobetalipoproteinemia. Molecular Immunology. 36: 869-76. PMID 10698341 DOI: 10.1016/S0161-5890(99)00108-X |
0.351 |
|
2000 |
Watanabe H, Garnier G, Circolo A, Wetsel RA, Ruiz P, Holers VM, Boackle SA, Colten HR, Gilkeson GS. Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. Journal of Immunology (Baltimore, Md. : 1950). 164: 786-94. PMID 10623824 DOI: 10.4049/Jimmunol.164.2.786 |
0.386 |
|
2000 |
Kildsgaard J, Hollmann T, Matthews K, Drouin S, Haviland D, Wetsel R. Contraposition of endotoxin-induced shock in C3A receptor- and C3-deficient mice Immunopharmacology. 49: 80. DOI: 10.1016/S0162-3109(00)80234-9 |
0.726 |
|
2000 |
Drouin SM, Kildsgaard J, Haviland J, Jia HP, McCray PB, Tack BF, Wetsel RA. Comparative expression of anaphylatoxin C3a and C5a receptors on lung bronchial epithelial and smooth muscle cells in mouse models of asthma and sepsis Immunopharmacology. 49: 26. DOI: 10.1016/S0162-3109(00)80081-8 |
0.467 |
|
1999 |
Circolo A, Garnier G, Fukuda W, Wang X, Hidvegi T, Szalai AJ, Briles DE, Volanakis JE, Wetsel RA, Colten HR. Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA. Immunopharmacology. 42: 135-49. PMID 10408374 DOI: 10.1016/S0162-3109(99)00021-1 |
0.398 |
|
1999 |
Wetsel RA, Kildsgaard J, Zsigmond E, Liao W, Chan L. Genetic deficiency of acylation stimulating protein (ASP(C3ades-Arg)) does not cause hyperapobetalipoproteinemia in mice. The Journal of Biological Chemistry. 274: 19429-33. PMID 10383458 DOI: 10.1074/Jbc.274.27.19429 |
0.348 |
|
1998 |
Lubinski JM, Wang L, Soulika AM, Burger R, Wetsel RA, Colten H, Cohen GH, Eisenberg RJ, Lambris JD, Friedman HM. Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo Journal of Virology. 72: 8257-8263. PMID 9733869 DOI: 10.1128/Jvi.72.10.8257-8263.1998 |
0.338 |
|
1998 |
Hollmann TJ, Haviland DL, Kildsgaard J, Watts K, Wetsel RA. Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene. Molecular Immunology. 35: 137-48. PMID 9694514 DOI: 10.1016/S0161-5890(98)00021-2 |
0.631 |
|
1998 |
Wang X, Circolo A, Lokki ML, Shackelford PG, Wetsel RA, Colten HR. Molecular heterogeneity in deficiency of complement protein C2 type I. Immunology. 93: 184-91. PMID 9616367 DOI: 10.1046/J.1365-2567.1998.00392.X |
0.336 |
|
1998 |
Zahedi R, Braun M, Wetsel RA, Davis AE. The C5a receptor is expressed by mesangial and proximal tubular epithelial cells Molecular Immunology. 35: 358. DOI: 10.1016/S0161-5890(98)90642-3 |
0.467 |
|
1996 |
Müller-Ladner U, Jones JL, Wetsel RA, Gay S, Raine CS, Barnum SR. Enhanced expression of chemotactic receptors in multiple sclerosis lesions. Journal of the Neurological Sciences. 144: 135-41. PMID 8994115 DOI: 10.1016/S0022-510X(96)00217-1 |
0.372 |
|
1996 |
Singer L, Van Hee ML, Lokki ML, Kramer J, Borzy MS, Wetsel RA. Inherited complement C3 deficiency: reduced C3 mRNA and protein levels in a Laotian kindred. Clinical Immunology and Immunopathology. 81: 244-52. PMID 8938101 DOI: 10.1006/Clin.1996.0185 |
0.335 |
|
1996 |
Wetsel RA, Kulics J, Lokki ML, Kiepiela P, Akama H, Johnson CA, Densen P, Colten HR. Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion. The Journal of Biological Chemistry. 271: 5824-31. PMID 8621452 DOI: 10.1074/Jbc.271.10.5824 |
0.315 |
|
1995 |
Wetsel RA. Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells. Immunology Letters. 44: 183-7. PMID 7797249 DOI: 10.1016/0165-2478(94)00212-A |
0.392 |
|
1995 |
Wetsel RA. Structure, function and cellular expression of complement anaphylatoxin receptors. Current Opinion in Immunology. 7: 48-53. PMID 7772282 DOI: 10.1016/0952-7915(95)80028-X |
0.466 |
|
1995 |
Lacy M, Jones J, Whittemore SR, Haviland DL, Wetsel RA, Barnum SR. Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia Journal of Neuroimmunology. 61: 71-78. PMID 7560015 DOI: 10.1016/0165-5728(95)00075-D |
0.401 |
|
1995 |
McCoy R, Haviland DL, Molmenti EP, Ziambaras T, Wetsel RA, Perlmutter DH. N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation Journal of Experimental Medicine. 182: 207-217. PMID 7540650 DOI: 10.1084/Jem.182.1.207 |
0.438 |
|
1994 |
Singer L, Colten HR, Wetsel RA. Complement C3 deficiency: human, animal, and experimental models. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology. 62: 14-28. PMID 8031472 DOI: 10.1159/000163873 |
0.372 |
|
1994 |
Katz Y, Singer L, Wetsel RA, Schlesinger M, Fishelson Z. Inherited complement C3 deficiency: a defect in C3 secretion. European Journal of Immunology. 24: 1517-22. PMID 8026514 DOI: 10.1002/Eji.1830240709 |
0.306 |
|
1992 |
Kawamura N, Singer L, Wetsel RA, Colten HR. Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene. The Biochemical Journal. 705-12. PMID 1590761 DOI: 10.1042/Bj2830705 |
0.319 |
|
1992 |
Johnson CA, Densen P, Wetsel RA, Cole FS, Goeken NE, Colten HR. Molecular heterogeneity of C2 deficiency. The New England Journal of Medicine. 326: 871-4. PMID 1542325 DOI: 10.1056/Nejm199203263261306 |
0.3 |
|
1987 |
Wetsel RA, Ogata RT, Tack BF. Primary structure of the fifth component of murine complement. Biochemistry. 26: 737-43. PMID 2436653 DOI: 10.1021/Bi00377A013 |
0.308 |
|
1985 |
Sottrup-Jensen L, Stepanik TM, Kristensen T, Lønblad PB, Jones CM, Wierzbicki DM, Magnusson S, Domdey H, Wetsel RA, Lundwall A. Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4. Proceedings of the National Academy of Sciences of the United States of America. 82: 9-13. PMID 2578664 DOI: 10.1073/Pnas.82.1.9 |
0.312 |
|
1982 |
Wetsel RA, Kolb WP. Expression of C5a-like biological activity by the fifth component of human complement upon limited digestion with non-complement enzymes without release of polypeptide fragments Molecular Immunology. 19: 1409. DOI: 10.1016/0161-5890(82)90176-6 |
0.391 |
|
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