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Simon A. Hinke, Ph.D. - Publications

Affiliations: 
2003 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Animal Physiology Biology, Molecular Biology
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Du F, Hinke S, Cavanaugh C, Polidori D, Wallace N, Kirchner T, Jennis M, Lang W, Kuo GH, Gaul M, Lenhard J, Demarest K, Ajami NJ, Liang Y, Hornby PJ. Potent SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents. The Journal of Pharmacology and Experimental Therapeutics. PMID 29674332 DOI: 10.1124/jpet.118.248575  0.352
2018 Hinke SA, Cieniewicz AM, Kirchner T, D'Aquino K, Nanjunda R, Aligo J, Perkinson R, Cooper P, Boayke K, Chiu ML, Jarantow S, Lacy ER, Liang Y, Johnson DL, Whaley JM, et al. Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody. Molecular Metabolism. PMID 29453154 DOI: 10.1016/j.molmet.2018.01.014  0.38
2016 Cieniewicz AM, Kirchner T, Hinke SA, Nanjunda R, D'Aquino K, Boayke K, Cooper PR, Perkinson R, Chiu ML, Johnson DL, Whaley JM, Lacy ER, Lingham RB, Liang Y, Kihm AJ. Novel Monoclonal Antibody is an Allosteric Insulin Receptor Antagonist that Induces Insulin Resistance. Diabetes. PMID 27797911 DOI: 10.2337/db16-0633  0.429
2014 Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circulation Research. 114: 607-15. PMID 24323672 DOI: 10.1161/Circresaha.114.302168  0.325
2012 Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. The Embo Journal. 31: 3991-4004. PMID 22940692 DOI: 10.1038/Emboj.2012.244  0.498
2012 Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Erratum: Anchored phosphatases modulate glucose homeostasis (EMBO Journal (2012) 31 (3991-4004) DOI: 10.1038/emboj.2012.244) The Embo Journal. 31: 4481-4481. DOI: 10.1038/Emboj.2012.297  0.431
2011 Hinke SA. Inverse vaccination with islet autoantigens to halt progression of autoimmune diabetes Drug Development Research. 72: 788-804. DOI: 10.1002/Ddr.20488  0.388
2009 Hinke SA. Epac2: a molecular target for sulfonylurea-induced insulin release. Science Signaling. 2: pe54. PMID 19706871 DOI: 10.1126/Scisignal.285Pe54  0.41
2007 Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. British Journal of Pharmacology. 150: 1031-43. PMID 17339833 DOI: 10.1038/Sj.Bjp.0707189  0.34
2007 Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radical Biology & Medicine. 42: 64-78. PMID 17157194 DOI: 10.1016/J.Freeradbiomed.2006.09.018  0.392
2006 Hinke SA, Pederson RA, McIntosh CH. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM). Advances in Experimental Medicine and Biology. 575: 119-33. PMID 16700515 DOI: 10.1007/0-387-32824-6_13  0.656
2005 Martens GA, Cai Y, Hinke S, Stangé G, Van de Casteele M, Pipeleers D. Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. The Journal of Biological Chemistry. 280: 20389-96. PMID 15774474 DOI: 10.1074/Jbc.M411869200  0.429
2005 Martens G, Cai Y, Hinke S, Stangé G, Van de Casteele M, Pipeleers D. Nutrient sensing in pancreatic beta cells suppresses mitochondrial superoxide generation and its contribution to apoptosis. Biochemical Society Transactions. 33: 300-1. PMID 15667332 DOI: 10.1042/Bst0330300  0.385
2004 Hinke SA, Manhart S, Speck M, Pederson RA, Demuth HU, McIntosh CH. In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide. Life Sciences. 75: 1857-70. PMID 15302229 DOI: 10.1016/J.Lfs.2004.03.024  0.705
2004 Delmeire D, Flamez D, Moens K, Hinke SA, Van Schravendijk C, Pipeleers D, Schuit F. Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochemical Pharmacology. 68: 33-9. PMID 15183115 DOI: 10.1016/J.Bcp.2004.02.035  0.52
2004 Hinke SA, Hellemans K, Schuit FC. Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal. The Journal of Physiology. 558: 369-80. PMID 15181163 DOI: 10.1113/Jphysiol.2004.064881  0.51
2004 Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. Diabetes. 53: 1326-35. PMID 15111503 DOI: 10.2337/Diabetes.53.5.1326  0.562
2004 Hinke SA, Manhart S, Kühn-Wache K, Nian C, Demuth HU, Pederson RA, McIntosh CH. [Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo. The Journal of Biological Chemistry. 279: 3998-4006. PMID 14610075 DOI: 10.1074/Jbc.M311304200  0.729
2003 Delmeire D, Flamez D, Hinke SA, Cali J, Pipeleers D, Schuit F. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia. 46: 1383-1393. PMID 13680124 DOI: 10.1007/S00125-003-1203-8  0.465
2003 Hinke SA, Gelling R, Manhart S, Lynn F, Pederson RA, Kühn-Wache K, Rosche F, Demuth HU, Coy D, McIntosh CH. Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP). Biological Chemistry. 384: 403-7. PMID 12715891 DOI: 10.1515/Bc.2003.046  0.662
2003 Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH. Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential. Advances in Experimental Medicine and Biology. 524: 293-301. PMID 12675251 DOI: 10.1007/0-306-47920-6_35  0.762
2003 Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU. Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. Biochemistry. 42: 3081-8. PMID 12627975 DOI: 10.1021/Bi026868E  0.681
2003 Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. American Journal of Physiology. Endocrinology and Metabolism. 284: E931-9. PMID 12540373 DOI: 10.1152/Ajpendo.00270.2002  0.77
2003 Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 91-3. PMID 12475913 DOI: 10.1096/Fj.02-0243Fje  0.774
2002 Demuth HU, Hinke SA, Pederson RA, McIntosh CH. Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective". Biochemical and Biophysical Research Communications. 296: 229-32. PMID 12163006 DOI: 10.1016/S0006-291X(02)00753-2  0.596
2002 Hinke SA, McIntosh CH, Hoffmann T, Kühn-Wache K, Wagner L, Bär J, Manhart S, Wermann M, Pederson RA, Demuth HU. On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors. Diabetes Care. 25: 1490-1; author reply. PMID 12145269 DOI: 10.2337/Diacare.25.8.1490-B  0.673
2002 Hinke SA, Kühn-Wache K, Hoffmann T, Pederson RA, McIntosh CH, Demuth HU. Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1. Biochemical and Biophysical Research Communications. 291: 1302-8. PMID 11883961 DOI: 10.1006/Bbrc.2002.6607  0.656
2002 Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH. Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. 51: 652-61. PMID 11872663 DOI: 10.2337/Diabetes.51.3.652  0.722
2001 Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH. Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP). Biochimica Et Biophysica Acta. 1547: 143-55. PMID 11343800 DOI: 10.1016/S0167-4838(01)00181-9  0.752
2001 Pospisilik JA, Hinke SA, Pederson RA, Hoffmann T, Rosche F, Schlenzig D, Glund K, Heiser U, McIntosh CH, Demuth H. Metabolism of glucagon by dipeptidyl peptidase IV (CD26). Regulatory Peptides. 96: 133-41. PMID 11111019 DOI: 10.1016/S0167-0115(00)00170-1  0.653
2000 Kühn-Wache K, Manhart S, Hoffmann T, Hinke SA, Gelling R, Pederson RA, McIntosh CH, Demuth HU. Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance. Advances in Experimental Medicine and Biology. 477: 187-95. PMID 10849746 DOI: 10.1007/0-306-46826-3_21  0.681
2000 Hinke SA, Pauly RP, Ehses J, Kerridge P, Demuth HU, McIntosh CH, Pederson RA. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide. The Journal of Endocrinology. 165: 281-91. PMID 10810292 DOI: 10.1677/Joe.0.1650281  0.77
2000 Hinke SA, Pospisilik JA, Demuth HU, Mannhart S, Kühn-Wache K, Hoffmann T, Nishimura E, Pederson RA, McIntosh CH. Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs. The Journal of Biological Chemistry. 275: 3827-34. PMID 10660533 DOI: 10.1074/Jbc.275.6.3827  0.701
1999 McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA. Glucose-Dependent Insulinotropic Polypeptide Stimulation of Lipolysis in Differentiated 3T3-L1 Cells: Wortmannin-Sensitive Inhibition by Insulin* * This work was supported by grants from Zymogenetics Inc. (Seattle, WA), the Medical Research Council of Canada (5-90007-RAP/CHSM) and the Canadian Diabetes Association (CHSM/RAP). Endocrinology. 140: 398-404. PMID 28200744 DOI: 10.1210/endo.140.1.6464  0.359
1999 Wheeler MB, Gelling RW, Hinke SA, Tu B, Pederson RA, Lynn F, Ehses J, McIntosh CH. Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization. The Journal of Biological Chemistry. 274: 24593-601. PMID 10455124 DOI: 10.1074/Jbc.274.35.24593  0.761
1999 McIntosh CH, Bremsak I, Lynn FC, Gill R, Hinke SA, Gelling R, Nian C, McKnight G, Jaspers S, Pederson RA. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology. 140: 398-404. PMID 9886851 DOI: 10.1210/Endo.140.1.6464  0.702
1997 Gelling RW, Coy DH, Pederson RA, Wheeler MB, Hinke S, Kwan T, McIntosh CH. GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro. Regulatory Peptides. 69: 151-4. PMID 9226399 DOI: 10.1016/S0167-0115(97)00009-8  0.697
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