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Lloyd C. Trotman - Publications

Affiliations: 
Molecular and Cellular Biology Stony Brook University, Stony Brook, NY, United States 
Area:
Molecular Biology, Cell Biology, Oncology
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Amit M, Anastasaki C, Dantzer R, Demir IE, Deneen B, Dixon KO, Egeblad M, Gibson EM, Hervey-Jumper SL, Hondermarck H, Magnon C, Monje M, Na'ara S, Pan Y, Repasky EA, ... ... Trotman LC, et al. Next Directions in the Neuroscience of Cancers Arising outside the CNS. Cancer Discovery. 14: 669-673. PMID 38571430 DOI: 10.1158/2159-8290.CD-23-1495  0.322
2023 M Swamynathan M, Mathew G, Aziz A, Gordon C, Hillowe A, Wang H, Jhaveri A, Kendall J, Cox H, Giarrizzo M, Azabdaftari G, Rizzo RC, Diermeier SD, Ojima I, Bialkowska AB, ... ... Trotman LC, et al. FABP5 Inhibition against -Mutant Therapy Resistant Prostate Cancer. Cancers. 16. PMID 38201488 DOI: 10.3390/cancers16010060  0.435
2023 Hillowe A, Gordon C, Wang L, Rizzo RC, Trotman LC, Ojima I, Bialkowska A, Kaczocha M. Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells. Plos One. 18: e0292483. PMID 37796964 DOI: 10.1371/journal.pone.0292483  0.464
2023 Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, ... ... Trotman L, et al. The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells. Nature Cancer. PMID 37460872 DOI: 10.1038/s43018-023-00594-z  0.519
2022 Aakula A, Isomursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, Li SP, Trotman L, Taimen P, Rannikko A, Lammerding J, et al. PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers. Molecular Oncology. PMID 36461911 DOI: 10.1002/1878-0261.13353  0.437
2021 Taranda J, Mathew G, Watrud K, El-Amine N, Lee MF, Elowsky C, Bludova A, Escobar Avelar S, Nowak DG, Wee TL, Wilkinson JE, Trotman LC, Osten P. Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases. Cell Reports. 37: 110027. PMID 34788609 DOI: 10.1016/j.celrep.2021.110027  0.394
2020 Oni TE, Biffi G, Baker LA, Hao Y, Tonelli C, Somerville TDD, Deschênes A, Belleau P, Hwang CI, Sánchez-Rivera FJ, Cox H, Brosnan E, Doshi A, Lumia RP, Khaledi K, ... ... Trotman LC, et al. SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. The Journal of Experimental Medicine. 217. PMID 32633781 DOI: 10.1084/Jem.20192389  0.383
2020 Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, ... ... Trotman LC, et al. Roadmap for the Emerging Field of Cancer Neuroscience. Cell. 181: 219-222. PMID 32302564 DOI: 10.1016/J.Cell.2020.03.034  0.43
2020 Mathew G, Trotman LC. Competence against insufficiency: Why are men mostly safe from a rare and deadly prostate cancer? The Journal of Experimental Medicine. 217. PMID 32236496 DOI: 10.1084/Jem.20200087  0.523
2019 Lee MF, Trotman LC. PTEN: Bridging Endocytosis and Signaling. Cold Spring Harbor Perspectives in Medicine. PMID 31818848 DOI: 10.1101/Cshperspect.A036103  0.362
2019 Carbonetti G, Converso C, Clement T, Wang C, Trotman L, Ojima I, Kaczocha M. Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth. The Prostate. PMID 31661167 DOI: 10.1002/Pros.23921  0.507
2019 Froeling FEM, Mosur Swamynathan M, Deschênes A, Chio IIC, Brosnan E, Yao MA, Alagesan P, Lucito MS, Li J, Chang AY, Trotman LC, Belleau P, Park Y, Rogoff HA, Watson JD, et al. Bioactivation of napabucasin triggers reactive oxygen species-mediated cancer cell death. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31527169 DOI: 10.1158/1078-0432.Ccr-19-0302  0.366
2019 Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, ... Trotman LC, et al. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. The Journal of Cell Biology. PMID 31092557 DOI: 10.1083/Jcb.201902048  0.585
2018 Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, ... ... Trotman LC, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science (New York, N.Y.). 361. PMID 30262472 DOI: 10.1126/Science.Aao4227  0.44
2018 Naguib A, Mathew G, Reczek CR, Watrud K, Ambrico A, Herzka T, Salas IC, Lee MF, El-Amine N, Zheng W, Di Francesco ME, Marszalek JR, Pappin DJ, Chandel NS, Trotman LC. Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Reports. 23: 58-67. PMID 29617673 DOI: 10.1016/J.Celrep.2018.03.032  0.391
2018 D'Andrea V, Nowak D, Watrud K, Ambrico A, Casanova-Salas I, Trotman L. Abstract 1097: The Phlpp2 phosphatase protects Myc and is a target for the prevention of prostate cancer metastasis Cancer Research. 78: 1097-1097. DOI: 10.1158/1538-7445.Am2018-1097  0.543
2017 Alexander J, Kendall J, McIndoo J, Rodgers L, Aboukhalil R, Levy D, Stepansky A, Sun G, Chobadjiev L, Riggs M, Cox H, Hakker I, Nowak DG, Laze J, Llukani E, ... ... Trotman LC, et al. Utility of single cell genomics in diagnostic evaluation of prostate cancer. Cancer Research. PMID 29180472 DOI: 10.1158/0008-5472.Can-17-1138  0.457
2017 Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, ... ... Trotman LC, et al. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. The Journal of Cell Biology. PMID 28193700 DOI: 10.1083/Jcb.201604025  0.455
2016 Labbé DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, Bégin LR, Trotman LC, Paquet M, Tremblay ML. PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers. Cancer Research. PMID 27020859 DOI: 10.1158/0008-5472.Can-15-1501  0.562
2016 Labbé DP, Uetani N, Vinette V, Aubry I, Migon E, Sirois J, Haigh JJ, Lessard L, Bégin LR, Trotman LC, Paquet M, Tremblay ML. Abstract B39: PTP1B deficiency potentiate prostate cancer invasiveness by sensitizing Pten-null tumors to high-fat diet Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B39  0.508
2016 Stahlhut CE, Ambrico AJ, Watrud KE, Cho H, Wang L, Qi J, Cantley LC, Bradner J, Trotman L. Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer Cancer Research. 76: 4165-4165. DOI: 10.1158/1538-7445.Am2016-4165  0.74
2015 Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt CP, Chen M, Zong WX, Marks MS, Joshua-Tor L, Pappin DJ, Trotman LC. PTEN functions by recruitment to cytoplasmic vesicles. Molecular Cell. 58: 255-68. PMID 25866245 DOI: 10.1016/J.Molcel.2015.03.011  0.613
2015 Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, ... ... Trotman LC, et al. MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer Discovery. 5: 636-51. PMID 25829425 DOI: 10.1158/2159-8290.Cd-14-1113  0.727
2015 Cho H, Herzka T, Stahlhut C, Watrud K, Robinson BD, Trotman LC. Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome. Methods (San Diego, Calif.). 77: 197-204. PMID 25592467 DOI: 10.1016/J.Ymeth.2014.12.022  0.698
2015 Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt C, Chen M, Zong W, Marks MS, Joshua-Tor L, Pappin DJ, Trotman LC. Abstract LB-063: PTEN function is controlled by recruitment to cytoplasmic vesicles Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-063  0.575
2015 Stahlhut CE, Watrud KE, Ambrico AJ, Cho H, Wang L, Qi J, Cantley LC, Bradner J, Trotman LC. Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer Cancer Research. 75: 2636-2636. DOI: 10.1158/1538-7445.Am2015-2636  0.732
2015 Nowak DG, Cho H, Herzka T, Wang VMY, Senturk S, DeMarco DV, Ding D, Fellmann C, Beinortas T, Kleinman D, Watrud K, Chen M, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, ... ... Trotman LC, et al. Abstract 2258: Myc drives Pten/ p53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2 Cancer Research. 75: 2258-2258. DOI: 10.1158/1538-7445.Am2015-2258  0.675
2014 Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proceedings of the National Academy of Sciences of the United States of America. 111: E3957-65. PMID 25201979 DOI: 10.1073/Pnas.1404221111  0.345
2014 Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, ... ... Trotman LC, et al. A unified nomenclature and amino acid numbering for human PTEN. Science Signaling. 7: pe15. PMID 24985344 DOI: 10.1126/Scisignal.2005560  0.31
2014 Chen M, Nowak DG, Trotman LC. Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 3057-63. PMID 24928944 DOI: 10.1158/1078-0432.Ccr-12-3680  0.492
2014 Cho H, Herzka T, Zheng W, Qi J, Wilkinson JE, Bradner JE, Robinson BD, Castillo-Martin M, Cordon-Cardo C, Trotman LC. RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Discovery. 4: 318-333. PMID 24444712 DOI: 10.1158/2159-8290.Cd-13-0346  0.738
2014 Newton AC, Trotman LC. Turning off AKT: PHLPP as a drug target. Annual Review of Pharmacology and Toxicology. 54: 537-58. PMID 24392697 DOI: 10.1146/Annurev-Pharmtox-011112-140338  0.456
2014 Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML. Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Molecular Cancer Research : McR. 12: 184-9. PMID 24379448 DOI: 10.1158/1541-7786.Mcr-13-0477  0.466
2013 Naguib A, Trotman LC. PTEN plasticity: how the taming of a lethal gene can go too far. Trends in Cell Biology. 23: 374-9. PMID 23578748 DOI: 10.1016/J.Tcb.2013.03.003  0.446
2013 Chen M, Herzka TM, Zeeman ME, Plafker KS, Minderer M, Castillo-Martin M, Cordon-Cardo C, Plafker SM, Trotman LC. Abstract 5258: PTEN levels are controlled by a nuclear transport receptor in lung cancer. Cancer Research. 73: 5258-5258. DOI: 10.1158/1538-7445.Am2013-5258  0.322
2013 Cho H, Herzka T, Zheng W, Castillo-Martin M, Cordon-Cardo C, Trotman LC. Abstract 4091: RapidCap: A new generation of mouse models for prostate cancer. Cancer Research. 73: 4091-4091. DOI: 10.1158/1538-7445.Am2013-4091  0.704
2012 Lessard L, Labbé DP, Deblois G, Bégin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguère V, Tremblay ML. PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Research. 72: 1529-37. PMID 22282656 DOI: 10.1158/0008-5472.Can-11-2602  0.562
2012 Howitt J, Lackovic J, Low LH, Naguib A, Macintyre A, Goh CP, Callaway JK, Hammond V, Thomas T, Dixon M, Putz U, Silke J, Bartlett P, Yang B, Kumar S, ... Trotman LC, et al. Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. The Journal of Cell Biology. 196: 29-36. PMID 22213801 DOI: 10.1083/Jcb.201105009  0.364
2011 Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, ... ... Trotman LC, et al. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 20: 173-86. PMID 21840483 DOI: 10.1016/J.Ccr.2011.07.013  0.593
2011 Trotman LC. Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era. Molecular Biology of the Cell. 22: 715. PMID 21406578 DOI: 10.1091/Mbc.E10-12-0956  0.391
2011 Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, ... ... Trotman LC, et al. Abstract 2405: Identification of PHLPP as a tumour suppressor reveals the role of pathway feedback compensation in PTEN-mutant prostate cancer progression Cancer Research. 71: 2405-2405. DOI: 10.1158/1538-7445.Am2011-2405  0.611
2011 Naguib A, Nowak DG, Chen M, Trotman LC. Abstract 1269: Identifying Pten-sensitive drug therapy through metabolic phenotype-arrays Cancer Research. 71: 1269-1269. DOI: 10.1158/1538-7445.Am2011-1269  0.566
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... Trotman LC, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/Nbt0910-904  0.453
2010 Trotman L, Powers S. New views into the prostate cancer genome. Cancer Cell. 18: 1-2. PMID 20609345 DOI: 10.1016/J.Ccr.2010.06.011  0.518
2010 Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A, Salmena L, Sampieri K, Haveman WJ, Brogi E, Richardson AL, Zhang J, Pandolfi PP. Subtle variations in Pten dose determine cancer susceptibility. Nature Genetics. 42: 454-8. PMID 20400965 DOI: 10.1038/Ng.556  0.339
2010 Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis Journal of Clinical Investigation. 120: 681-693. PMID 20197621 DOI: 10.1172/Jci40535  0.55
2010 Alimonti A, Nardella C, Pavese I, Clohessy JG, Carracedo A, Trotman LC, Woscholski R, Cognetti F, Scher HI, Pandolfi P. PTEN and MDM2 inhibitors: Toward a novel pro-senescence therapy approach for patients with cancer. Journal of Clinical Oncology. 28: e13572-e13572. DOI: 10.1200/Jco.2010.28.15_Suppl.E13572  0.338
2008 Trotman L. Lloyd Trotman: of mice and men, cancer, and PTEN. Interviewed by Caitlin Sedwick. The Journal of Cell Biology. 181: 402-3. PMID 18458154 DOI: 10.1083/jcb.1813pi  0.31
2007 Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, et al. Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression Cell. 128: 141-156. PMID 17218261 DOI: 10.1016/J.Cell.2006.11.040  0.455
2007 Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 128: 129-39. PMID 17218260 DOI: 10.1016/J.Cell.2006.11.039  0.475
2007 Carver BS, Lin H, Chen Z, Trotman L, Scardino PT, Pandolfi PP. 663: XPD (ERCC-2) and Prostate Cancer: Susceptibility Depends on the Degree of DNA Damage and Transcriptional Interference Journal of Urology. 177: 222-223. DOI: 10.1016/S0022-5347(18)30903-0  0.48
2006 Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP. Identification of a tumour suppressor network opposing nuclear Akt function. Nature. 441: 523-7. PMID 16680151 DOI: 10.1038/Nature04809  0.491
2005 Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 436: 725-30. PMID 16079851 DOI: 10.1038/Nature03918  0.581
2003 Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van Dyke T, Cordon-Cardo C, Pandolfi PP. Pten dose dictates cancer progression in the prostate. Plos Biology. 1: E59. PMID 14691534 DOI: 10.1371/Journal.Pbio.0000059  0.572
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