| Year |
Citation |
Score |
| 2017 |
Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Archives of Biochemistry and Biophysics. PMID 28526426 DOI: 10.1016/j.abb.2017.05.010 |
0.424 |
|
| 2016 |
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3β Increases Basal Autophagy and AMPK Signaling in Nutrient-laden Human Aortic Endothelial Cells. Bioscience Reports. PMID 27534430 DOI: 10.1042/Bsr20160174 |
0.765 |
|
| 2016 |
Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism: Clinical and Experimental. 65: 634-45. PMID 27085772 DOI: 10.1016/J.Metabol.2016.01.005 |
0.745 |
|
| 2016 |
Pepin É, Al-Mass A, Attané C, Zhang K, Lamontagne J, Lussier R, Madiraju SR, Joly E, Ruderman NB, Sladek R, Prentki M, Peyot ML. Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression. Plos One. 11: e0153017. PMID 27043434 DOI: 10.1371/Journal.Pone.0153017 |
0.366 |
|
| 2016 |
Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. The Journal of Biological Chemistry. PMID 26797128 DOI: 10.1074/Jbc.M115.696849 |
0.443 |
|
| 2015 |
Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 64: 3155-9. PMID 26001396 DOI: 10.2337/Db14-1765 |
0.422 |
|
| 2015 |
Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. Plos One. 10: e0127388. PMID 25996822 DOI: 10.1371/journal.pone.0127388 |
0.427 |
|
| 2015 |
Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. Plos One. 10: e0121959. PMID 25798922 DOI: 10.1371/journal.pone.0121959 |
0.342 |
|
| 2015 |
Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. Plos One. 10: e0115341. PMID 25647160 DOI: 10.1371/journal.pone.0115341 |
0.341 |
|
| 2015 |
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. American Journal of Physiology. Cell Physiology. 308: C249-63. PMID 25354528 DOI: 10.1152/Ajpcell.00265.2014 |
0.772 |
|
| 2014 |
Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Archives of Biochemistry and Biophysics. 562: 62-9. PMID 25172224 DOI: 10.1016/j.abb.2014.08.013 |
0.427 |
|
| 2014 |
Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 7: 241-53. PMID 25018645 DOI: 10.2147/DMSO.S43731 |
0.456 |
|
| 2014 |
Xu XJ, Valentine RJ, Ruderman NB. AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Current Obesity Reports. 3: 248-55. PMID 24891985 DOI: 10.1007/s13679-014-0095-x |
0.334 |
|
| 2014 |
Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. Plos One. 9: e97554. PMID 24835252 DOI: 10.1371/Journal.Pone.0097554 |
0.717 |
|
| 2013 |
Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. Journal of Endocrinology, Diabetes & Obesity. 1: 1008. PMID 26120590 |
0.469 |
|
| 2013 |
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. The Journal of Clinical Investigation. 123: 2764-72. PMID 23863634 DOI: 10.1172/Jci67227 |
0.743 |
|
| 2013 |
Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes. 62: 2122-9. PMID 23378607 DOI: 10.2337/Db12-0428 |
0.311 |
|
| 2013 |
Tabit CE, Shenouda SM, Holbrook M, Fetterman JL, Kiani S, Frame AA, Kluge MA, Held A, Dohadwala MM, Gokce N, Farb MG, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM. Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 127: 86-95. PMID 23204109 DOI: 10.1161/Circulationaha.112.127514 |
0.432 |
|
| 2012 |
Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. Plos One. 7: e35092. PMID 22514710 DOI: 10.1371/Journal.Pone.0035092 |
0.724 |
|
| 2012 |
Ix JH, Biggs ML, Mukamal KJ, Kizer JR, Zieman SJ, Siscovick DS, Mozzaffarian D, Jensen MK, Nelson L, Ruderman N, Djousse L. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 125: 2316-22. PMID 22511752 DOI: 10.1161/Circulationaha.111.072751 |
0.315 |
|
| 2012 |
Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. American Journal of Physiology. Cell Physiology. 303: C4-C13. PMID 22378745 DOI: 10.1152/Ajpcell.00296.2011 |
0.752 |
|
| 2012 |
Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. Journal of Lipid Research. 53: 792-801. PMID 22323564 DOI: 10.1194/Jlr.P022905 |
0.739 |
|
| 2011 |
Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle (Georgetown, Tex.). 10: 3447-51. PMID 22067655 DOI: 10.4161/cc.10.20.17886 |
0.432 |
|
| 2011 |
Chuang JH, Kao YJ, Ruderman NB, Tung LC, Lin Y. Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins. Analytical Biochemistry. 418: 298-300. PMID 21871431 DOI: 10.1016/J.Ab.2011.08.006 |
0.49 |
|
| 2011 |
Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1255-65. PMID 21724864 DOI: 10.1152/Ajpheart.01279.2010 |
0.736 |
|
| 2011 |
Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics. 509: 133-41. PMID 21420928 DOI: 10.1016/j.abb.2011.03.008 |
0.355 |
|
| 2011 |
Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Investigative Ophthalmology & Visual Science. 52: 3630-9. PMID 21345991 DOI: 10.1167/Iovs.10-5784 |
0.749 |
|
| 2011 |
Gauthier MS, O'Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochemical and Biophysical Research Communications. 404: 382-7. PMID 21130749 DOI: 10.1016/J.Bbrc.2010.11.127 |
0.748 |
|
| 2010 |
Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 59: 2426-34. PMID 20682696 DOI: 10.2337/db09-1870 |
0.435 |
|
| 2010 |
Liu Q, Gauthier MS, Sun L, Ruderman N, Lodish H. Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: Requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio Faseb Journal. 24: 4229-4239. PMID 20667975 DOI: 10.1096/Fj.10-159723 |
0.543 |
|
| 2010 |
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? American Journal of Physiology. Endocrinology and Metabolism. 298: E751-60. PMID 20103737 DOI: 10.1152/Ajpendo.00745.2009 |
0.728 |
|
| 2009 |
Joly E, Roduit R, Peyot ML, Habinowski SA, Ruderman NB, Witters LA, Prentki M. Glucose represses PPARα gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell. Journal of Diabetes. 1: 263-72. PMID 20923527 DOI: 10.1111/J.1753-0407.2009.00043.X |
0.37 |
|
| 2009 |
Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M. Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 57: 963-71. PMID 19581628 DOI: 10.1369/Jhc.2009.954016 |
0.327 |
|
| 2009 |
Kelly M, Gauthier MS, Saha AK, Ruderman NB. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 58: 1953-60. PMID 19502419 DOI: 10.2337/Db08-1293 |
0.704 |
|
| 2009 |
Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology. 150: 3465-74. PMID 19406947 DOI: 10.1210/En.2008-1557 |
0.341 |
|
| 2009 |
Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. The Journal of Biological Chemistry. 284: 16848-59. PMID 19389712 DOI: 10.1074/Jbc.M109.006650 |
0.339 |
|
| 2009 |
Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. The Biochemical Journal. 418: 261-75. PMID 19196246 DOI: 10.1042/BJ20082055 |
0.401 |
|
| 2009 |
Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochemical and Biophysical Research Communications. 378: 836-41. PMID 19071085 DOI: 10.1016/J.Bbrc.2008.11.130 |
0.737 |
|
| 2008 |
Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. The Journal of Biological Chemistry. 283: 27628-35. PMID 18687677 DOI: 10.1074/Jbc.M805711200 |
0.769 |
|
| 2008 |
Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. The Journal of Biological Chemistry. 283: 16514-24. PMID 18390901 DOI: 10.1074/Jbc.M708177200 |
0.773 |
|
| 2006 |
Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 55: S48-54. PMID 17130644 DOI: 10.2337/Db06-S007 |
0.708 |
|
| 2006 |
Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring, Md.). 14: 25S-33S. PMID 16642960 DOI: 10.1038/oby.2006.279 |
0.35 |
|
| 2006 |
LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. American Journal of Physiology. Endocrinology and Metabolism. 291: E175-81. PMID 16464908 DOI: 10.1152/Ajpendo.00453.2005 |
0.739 |
|
| 2006 |
Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, et al. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. American Journal of Physiology. Endocrinology and Metabolism. 290: E1296-303. PMID 16434556 DOI: 10.1152/ajpendo.00341.2005 |
0.336 |
|
| 2006 |
Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 281: 2654-60. PMID 16326714 DOI: 10.1074/Jbc.M505311200 |
0.39 |
|
| 2006 |
Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology. Endocrinology and Metabolism. 290: E471-9. PMID 16234268 DOI: 10.1152/ajpendo.00316.2005 |
0.395 |
|
| 2005 |
Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes. 54: 3458-65. PMID 16306362 DOI: 10.2337/Diabetes.54.12.3458 |
0.457 |
|
| 2005 |
Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. American Journal of Physiology. Endocrinology and Metabolism. 289: E794-800. PMID 15956049 DOI: 10.1152/Ajpendo.00144.2005 |
0.351 |
|
| 2005 |
Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 54: 1838-45. PMID 15919807 DOI: 10.2337/Diabetes.54.6.1838 |
0.731 |
|
| 2005 |
Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends in Pharmacological Sciences. 26: 69-76. PMID 15681023 DOI: 10.1016/J.Tips.2004.12.011 |
0.356 |
|
| 2005 |
Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochemical and Biophysical Research Communications. 326: 851-8. PMID 15607747 DOI: 10.1016/J.Bbrc.2004.11.114 |
0.334 |
|
| 2005 |
Ye J, Ruderman NB, Kraegen EW. AMP-activated protein kinase and malonyl-CoA: Targets for treating insulin resistance? Drug Discovery Today: Therapeutic Strategies. 2: 157-163. DOI: 10.1016/J.DDSTR.2005.05.019 |
0.368 |
|
| 2004 |
Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 47: 2012-21. PMID 15578153 DOI: 10.1007/S00125-004-1570-9 |
0.36 |
|
| 2004 |
Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications. 324: 1204-9. PMID 15504342 DOI: 10.1016/J.Bbrc.2004.09.177 |
0.746 |
|
| 2004 |
Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. The Journal of Biological Chemistry. 279: 47898-905. PMID 15371448 DOI: 10.1074/Jbc.M408149200 |
0.448 |
|
| 2004 |
Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB. Metabolic and hormonal interactions between muscle and adipose tissue. The Proceedings of the Nutrition Society. 63: 381-5. PMID 15294059 DOI: 10.1079/PNS2004356 |
0.691 |
|
| 2004 |
Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochemical and Biophysical Research Communications. 320: 449-54. PMID 15219849 DOI: 10.1016/J.Bbrc.2004.05.188 |
0.663 |
|
| 2004 |
Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nature Reviews. Drug Discovery. 3: 340-51. PMID 15060529 DOI: 10.1038/Nrd1344 |
0.471 |
|
| 2004 |
Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 53: 1007-19. PMID 15047616 DOI: 10.2337/Diabetes.53.4.1007 |
0.458 |
|
| 2004 |
Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochemical and Biophysical Research Communications. 314: 580-5. PMID 14733947 |
0.316 |
|
| 2003 |
Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Molecular and Cellular Biochemistry. 253: 65-70. PMID 14619957 |
0.449 |
|
| 2003 |
Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. The Journal of Biological Chemistry. 278: 50810-7. PMID 14522956 DOI: 10.1074/Jbc.M309469200 |
0.31 |
|
| 2003 |
Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 144: 5166-71. PMID 14500570 DOI: 10.1210/en.2003-0849 |
0.394 |
|
| 2003 |
Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise Acta Physiologica Scandinavica. 178: 435-442. PMID 12864749 DOI: 10.1046/J.1365-201X.2003.01164.X |
0.43 |
|
| 2003 |
Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 52: 1635-40. PMID 12829626 DOI: 10.2337/Diabetes.52.7.1635 |
0.37 |
|
| 2003 |
Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochemical Society Transactions. 31: 202-6. PMID 12546685 DOI: 10.1042/Bst0310202 |
0.79 |
|
| 2003 |
Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. The Journal of Clinical Endocrinology and Metabolism. 88: 82-7. PMID 12519834 DOI: 10.1210/jc.2002-020330 |
0.301 |
|
| 2003 |
Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes Care. 26: S73-7. PMID 12502622 DOI: 10.2337/Diacare.26.2007.S73 |
0.316 |
|
| 2002 |
Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation Proceedings of the National Academy of Sciences of the United States of America. 99: 16309-16313. PMID 12456889 DOI: 10.1073/Pnas.222657499 |
0.445 |
|
| 2002 |
Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 51: 2886-94. PMID 12351423 |
0.373 |
|
| 2002 |
Tomás E, Zorzano A, Ruderman NB. Exercise and insulin signaling: a historical perspective. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 765-72. PMID 12133890 DOI: 10.1152/japplphysiol.00267.2002 |
0.323 |
|
| 2002 |
Shafrir E, Ziv E, Saha AK, Ruderman NB. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes/Metabolism Research and Reviews. 18: 217-23. PMID 12112940 DOI: 10.1002/dmrr.288 |
0.344 |
|
| 2002 |
Lin Y, Brady MJ, Wolanske K, Holbert R, Ruderman NB, Yaney GC. Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle. American Journal of Physiology. Endocrinology and Metabolism. 283: E318-25. PMID 12110537 DOI: 10.1152/Ajpendo.00390.2001 |
0.675 |
|
| 2002 |
Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51: 2005-11. PMID 12086926 DOI: 10.2337/Diabetes.51.7.2005 |
0.381 |
|
| 2002 |
Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Annals of the New York Academy of Sciences. 967: 43-51. PMID 12079834 DOI: 10.1111/J.1749-6632.2002.Tb04262.X |
0.796 |
|
| 2002 |
Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. The Journal of Biological Chemistry. 277: 32571-7. PMID 12065578 DOI: 10.1074/Jbc.M201692200 |
0.377 |
|
| 2002 |
Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes Circulation. 105: e138-143. PMID 11994264 DOI: 10.1161/01.Cir.0000013954.65303.C5 |
0.394 |
|
| 2002 |
Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z. 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Molecular Endocrinology (Baltimore, Md.). 16: 552-62. PMID 11875115 DOI: 10.1210/Mend.16.3.0790 |
0.425 |
|
| 2002 |
Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 51: 159-67. PMID 11756336 DOI: 10.2337/Diabetes.51.1.159 |
0.551 |
|
| 2002 |
Sternthal E, Ruderman N. Insulin: Promise and problems at 80 years Current Opinion in Endocrinology & Diabetes. 9: 283-284. DOI: 10.1097/00060793-200208000-00001 |
0.32 |
|
| 2001 |
Patel N, Khayat ZA, Ruderman NB, Klip A. Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition. Biochemical and Biophysical Research Communications. 285: 1066-70. PMID 11467861 DOI: 10.1006/Bbrc.2001.5275 |
0.378 |
|
| 2001 |
Kaushik VK, Young ME, Dean DJ, Kurowski TG, Saha AK, Ruderman NB. Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. American Journal of Physiology. Endocrinology and Metabolism. 281: E335-40. PMID 11440910 DOI: 10.1152/AJPENDO.2001.281.2.E335 |
0.35 |
|
| 2001 |
Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circulation Research. 88: 1276-82. PMID 11420304 DOI: 10.1161/Hh1201.092998 |
0.746 |
|
| 2001 |
Lin Y, Itani SI, Kurowski TG, Dean DJ, Luo Z, Yaney GC, Ruderman NB. Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 281: E8-E15. PMID 11404218 DOI: 10.1152/Ajpendo.2001.281.1.E8 |
0.663 |
|
| 2001 |
Ruderman N, Flier JS. Cell biology. Chewing the fat--ACC and energy balance. Science (New York, N.Y.). 291: 2558-9. PMID 11286278 DOI: 10.1126/Science.1060277 |
0.304 |
|
| 2000 |
Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 49: 1295-300. PMID 10923628 DOI: 10.2337/Diabetes.49.8.1295 |
0.392 |
|
| 2000 |
Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Journal of Biological Chemistry. 275: 24279-24283. PMID 10854420 DOI: 10.1074/Jbc.C000291200 |
0.371 |
|
| 2000 |
Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. The American Journal of Physiology. 277: E1070-6. PMID 10600797 DOI: 10.1152/ajpendo.1999.277.6.E1070 |
0.387 |
|
| 1999 |
Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. American Journal of Physiology. Endocrinology and Metabolism. 276: E1-E18. PMID 29590890 DOI: 10.1152/ajpendo.1999.276.1.E1 |
0.481 |
|
| 1999 |
Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications. 265: 112-5. PMID 10548499 DOI: 10.1006/Bbrc.1999.1635 |
0.786 |
|
| 1999 |
Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. The American Journal of Physiology. 276: E1030-7. PMID 10362615 DOI: 10.1152/ajpendo.1999.276.6.E1030 |
0.317 |
|
| 1999 |
Ruderman NB, Dean D. Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle. Journal of Basic and Clinical Physiology and Pharmacology. 9: 295-308. PMID 10212840 DOI: 10.1515/JBCPP.1998.9.2-4.295 |
0.404 |
|
| 1999 |
Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia. 42: 310-6. PMID 10096783 DOI: 10.1007/S001250051156 |
0.447 |
|
| 1999 |
Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, Ruderman NB. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes. 48: 658-63. PMID 10078574 DOI: 10.2337/Diabetes.48.3.658 |
0.652 |
|
| 1998 |
Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW. Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Advances in Experimental Medicine and Biology. 441: 263-70. PMID 9781332 DOI: 10.1007/978-1-4899-1928-1_24 |
0.394 |
|
| 1998 |
Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 47: 699-713. PMID 9588440 DOI: 10.2337/Diabetes.47.5.699 |
0.359 |
|
| 1998 |
Khan F, Cohen RA, Ruderman NB, Chipkin SR, Coffman JD. Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus. Vascular Medicine (London, England). 1: 187-93. PMID 9546937 DOI: 10.1177/1358863X9600100303 |
0.308 |
|
| 1997 |
Oakes ND, Bell KS, Furler SM, Camilleri S, Saha AK, Ruderman NB, Chisholm DJ, Kraegen EW. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes. 46: 2022-8. PMID 9392490 DOI: 10.2337/DIAB.46.12.2022 |
0.334 |
|
| 1997 |
Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. The Journal of Biological Chemistry. 272: 13255-61. PMID 9148944 DOI: 10.1074/jbc.272.20.13255 |
0.314 |
|
| 1997 |
Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. The American Journal of Physiology. 272: E641-8. PMID 9142886 DOI: 10.1152/ajpendo.1997.272.4.E641 |
0.364 |
|
| 1996 |
Gupta S, Phipps K, Ruderman NB. Differential stimulation of Na+ pump activity by insulin and nitric oxide in rabbit aorta. The American Journal of Physiology. 270: H1287-93. PMID 8967368 DOI: 10.1152/ajpheart.1996.270.4.H1287 |
0.366 |
|
| 1995 |
Saha AK, Kurowski TG, Ruderman NB. A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. The American Journal of Physiology. 269: E283-9. PMID 7653546 DOI: 10.1152/ajpendo.1995.269.2.E283 |
0.321 |
|
| 1994 |
Chen KS, Heydrick SJ, Brown ML, Friel JC, Ruderman NB. Insulin increases a biochemically distinct pool of diacylglycerol in the rat soleus muscle. The American Journal of Physiology. 266: E479-85. PMID 8166270 DOI: 10.1152/ajpendo.1994.266.3.E479 |
0.319 |
|
| 1993 |
Chen KS, Friel JC, Ruderman NB. Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. The American Journal of Physiology. 265: E736-42. PMID 8238500 DOI: 10.1152/ajpendo.1993.265.5.E736 |
0.368 |
|
| 1992 |
Balon TW, Treadway JL, Hughes JB, Young JC, Ruderman NB. Effect of prior exercise and insulin on potential thermogenic systems in rat skeletal muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). 72: 2203-9. PMID 1629074 DOI: 10.1152/Jappl.1992.72.6.2203 |
0.32 |
|
| 1992 |
Coderre L, Monfar MM, Chen KS, Heydrick SJ, Kurowski TG, Ruderman NB, Pilch PF. Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles Endocrinology. 131: 1821-1825. PMID 1396328 DOI: 10.1210/Endo.131.4.1396328 |
0.306 |
|
| 1991 |
Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS. Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. Diabetes. 40: 1707-11. PMID 1756911 DOI: 10.2337/diab.40.12.1707 |
0.397 |
|
| 1991 |
Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Molecular Endocrinology (Baltimore, Md.). 5: 769-77. PMID 1656240 DOI: 10.1210/Mend-5-6-769 |
0.353 |
|
| 1990 |
Balon TW, Zorzano A, Treadway JL, Goodman MN, Ruderman NB. Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. The American Journal of Physiology. 258: E92-7. PMID 2405703 DOI: 10.1152/Ajpendo.1990.258.1.E92 |
0.314 |
|
| 1990 |
Ruderman N, Apelian AZ, Schneider SH. Exercise in therapy and prevention of type II diabetes. Implications for blacks. Diabetes Care. 13: 1163-8. PMID 2261837 DOI: 10.2337/Diacare.13.11.1163 |
0.326 |
|
| 1990 |
Ruderman NB, Kapeller R, White MF, Cantley LC. Activation of phosphatidylinositol 3-kinase by insulin Proceedings of the National Academy of Sciences of the United States of America. 87: 1411-1415. PMID 2154747 DOI: 10.1073/Pnas.87.4.1411 |
0.372 |
|
| 1989 |
Treadway JL, James DE, Burcel E, Ruderman NB. Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. The American Journal of Physiology. 256: E138-44. PMID 2643337 DOI: 10.1152/ajpendo.1989.256.1.E138 |
0.345 |
|
| 1987 |
Zorzano A, Balon TW, Jakubowski JA, Goodman MN, Deykin D, Ruderman NB. Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake. The Biochemical Journal. 240: 437-43. PMID 3545188 DOI: 10.1042/bj2400437 |
0.307 |
|
| 1987 |
Zorzano A, Balon TW, Goodman MN, Ruderman NB. Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. The American Journal of Physiology. 251: E664-9. PMID 3538900 DOI: 10.1152/ajpendo.1986.251.6.E664 |
0.327 |
|
| 1986 |
Zorzano A, Balon TW, Goodman MN, Ruderman NB. Additive effects of prior exercise and insulin on glucose and AIB uptake by rat muscle. The American Journal of Physiology. 251: E21-6. PMID 3524258 DOI: 10.1152/ajpendo.1986.251.1.E21 |
0.318 |
|
| 1986 |
Schneider SH, Vitug A, Ruderman N. Atherosclerosis and physical activity. Diabetes/Metabolism Reviews. 1: 513-53. PMID 3522141 DOI: 10.1002/Dmr.5610010410 |
0.325 |
|
| 1985 |
Zorzano A, Balon TW, Garetto LP, Goodman MN, Ruderman NB. Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin. The American Journal of Physiology. 248: E546-52. PMID 3887941 DOI: 10.1152/ajpendo.1985.248.5.E546 |
0.324 |
|
| 1985 |
Salzman R, Manson JE, Griffing GT, Kimmerle R, Ruderman N, McCall A, Stoltz EI, Mullin C, Small D, Armstrong J. Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. The New England Journal of Medicine. 312: 1078-84. PMID 3885035 DOI: 10.1056/Nejm198504253121702 |
0.395 |
|
| 1984 |
Richter EA, Garetto LP, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise: modulation by local factors. The American Journal of Physiology. 246: E476-82. PMID 6430094 DOI: 10.1152/ajpendo.1984.246.6.E476 |
0.333 |
|
| 1984 |
Garetto LP, Richter EA, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise in the rat: the two phases. The American Journal of Physiology. 246: E471-5. PMID 6377909 DOI: 10.1152/ajpendo.1984.246.6.E471 |
0.317 |
|
| 1982 |
Richter EA, Garetto LP, Goodman MN, Ruderman NB. Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. The Journal of Clinical Investigation. 69: 785-93. PMID 6804492 DOI: 10.1172/JCI110517 |
0.323 |
|
| 1981 |
Conover CA, Rozovski SJ, Ruderman NB. Regulation of ornithine decarboxylase in skeletal muscle: evidence for the involvement of an insulin-dependent serum factor. Diabetes. 30: 678-84. PMID 7018971 DOI: 10.2337/diab.30.8.678 |
0.328 |
|
| 1981 |
Brady LJ, Goodman MN, Kalish FN, Ruderman NB. Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. The American Journal of Physiology. 240: E184-90. PMID 7008629 DOI: 10.1152/ajpendo.1981.240.2.E184 |
0.307 |
|
| 1980 |
Conover CA, Rozovski SJ, Belur ER, Aoki TT, Ruderman NB. Ornithine decarboxylase activity in insulin-deficient states. The Biochemical Journal. 192: 725-32. PMID 7016116 DOI: 10.1042/bj1920725 |
0.307 |
|
| 1979 |
Goodman MN, Ruderman NB. Insulin sensitivity of rat skeletal muscle: effects of starvation and aging. The American Journal of Physiology. 236: E519-23. PMID 443372 DOI: 10.1152/ajpendo.1979.236.5.E519 |
0.311 |
|
| 1976 |
MacDonald M, Neufeldt N, Park BN, Berger M, Ruderman N. Alanine metabolism and gluconeogenesis in the rat. The American Journal of Physiology. 231: 619-26. PMID 961915 DOI: 10.1152/Ajplegacy.1976.231.2.619 |
0.331 |
|
| 1976 |
Berger M, Hagg SA, Goodman MN, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. The Biochemical Journal. 158: 191-202. PMID 136249 DOI: 10.1042/bj1580191 |
0.345 |
|
| 1975 |
Shafrir E, Ruderman NB. Enzymes of carbohydrate and fat metabolism in anti-insulin serum diabetes; inactivation by free fatty acids and the protective effect of cellular protein. Diabetologia. 10: 731-42. PMID 4155389 DOI: 10.1007/BF01219535 |
0.301 |
|
| 1975 |
Berger M, Hagg S, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. The Biochemical Journal. 146: 231-8. PMID 807202 DOI: 10.1042/bj1460231 |
0.333 |
|
| 1974 |
Ruderman NB, Goodman MN. Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis. The American Journal of Physiology. 226: 136-43. PMID 4203779 DOI: 10.1152/Ajplegacy.1974.226.1.136 |
0.313 |
|
| 1973 |
Ruderman NB, Goodman MN. Regulation of ketone body metabolism in skeletal muscle. The American Journal of Physiology. 224: 1391-7. PMID 4712152 DOI: 10.1152/Ajplegacy.1973.224.6.1391 |
0.311 |
|
| 1968 |
Ruderman NB, Herrera MG. Glucose regulation of hepatic gluconeogenesis. The American Journal of Physiology. 214: 1346-51. PMID 5649490 DOI: 10.1152/Ajplegacy.1968.214.6.1346 |
0.325 |
|
| 1968 |
Herrera MG, Kamm D, Ruderman N. Non-hormonal factors in the control of gluconeogenesis. Advances in Enzyme Regulation. 4: 225-35. PMID 4862942 DOI: 10.1016/0065-2571(66)90017-3 |
0.369 |
|
| 1967 |
Ruderman NB, Lauris V, Herrera MG. Insulin preservation of glucokinase activity in isolated perfused rat liver. The American Journal of Physiology. 212: 1169-73. PMID 4290362 DOI: 10.1152/Ajplegacy.1967.212.5.1169 |
0.382 |
|
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