Yueming Li - Publications

Affiliations: 
Cornell University, Ithaca, NY, United States 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Li YM, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.444
2020 Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/Acschemneuro.0C00389  0.485
2019 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052  0.438
2017 Johnson DS, Li YM, Pettersson M, St George-Hyslop PH. Structural and Chemical Biology of Presenilin Complexes. Cold Spring Harbor Perspectives in Medicine. PMID 28320827 DOI: 10.1101/Cshperspect.A024067  0.423
2017 Fried ES, Li YM, Gilchrist ML. Phase Composition Control in Microsphere-Supported Biomembrane Systems. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 28198634 DOI: 10.1021/Acs.Langmuir.6B04150  0.306
2017 Gertsik N, Am Ende CW, Geoghegan KF, Nguyen C, Mukherjee P, Mente S, Seneviratne U, Johnson DS, Li YM. Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes. Cell Chemical Biology. PMID 28065657 DOI: 10.1016/J.Chembiol.2016.12.006  0.44
2016 Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. Acs Chemical Neuroscience. PMID 27253220 DOI: 10.1021/Acschemneuro.6B00127  0.431
2016 Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence that the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. The Journal of Biological Chemistry. PMID 26887941 DOI: 10.1074/Jbc.C115.701649  0.425
2015 Gilchrist ML, Ahn K, Li YM. Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Analytical Chemistry. PMID 26699370 DOI: 10.1021/Acs.Analchem.5B03762  0.369
2014 Gertsik N, Chiu D, Li YM. Complex regulation of γ-secretase: from obligatory to modulatory subunits. Frontiers in Aging Neuroscience. 6: 342. PMID 25610395 DOI: 10.3389/Fnagi.2014.00342  0.507
2014 Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. The Journal of Biological Chemistry. 289: 34851-61. PMID 25352592 DOI: 10.1074/Jbc.M114.609636  0.485
2014 Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer. Cell Reports. 8: 1077-92. PMID 25131208 DOI: 10.1016/J.Celrep.2014.07.028  0.389
2014 Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM. Development of CBAP-BPyne, a probe for γ-secretase and presenilinase. Medchemcomm. 5: 338-341. PMID 24914408 DOI: 10.1039/C3Md00281K  0.474
2014 Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y, Djaballah H, Kharas MG. A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins. Combinatorial Chemistry & High Throughput Screening. 17: 596-609. PMID 24912481 DOI: 10.2174/1386207317666140609122714  0.309
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/Bi401537V  0.441
2013 Crump CJ, Johnson DS, Li YM. Development and mechanism of γ-secretase modulators for Alzheimer's disease. Biochemistry. 52: 3197-216. PMID 23614767 DOI: 10.1021/Bi400377P  0.523
2013 Chau DM, Shum D, Radu C, Bhinder B, Gin D, Gilchrist ML, Djaballah H, Li YM. A novel high throughput 1536-well notch1 γsecretase AlphaLISA assay Combinatorial Chemistry and High Throughput Screening. 16: 415-424. PMID 23448293 DOI: 10.2174/1386207311316060001  0.401
2013 Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. The Journal of Biological Chemistry. 288: 9710-20. PMID 23396974 DOI: 10.1074/Jbc.M112.398602  0.465
2013 Li Y. Endogenous and exogenous regulation of gamma-secretase Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O10  0.459
2012 Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 51: 7209-11. PMID 22931393 DOI: 10.1021/Bi301137H  0.419
2012 Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proceedings of the National Academy of Sciences of the United States of America. 109: 8534-9. PMID 22586122 DOI: 10.1073/Pnas.1202691109  0.412
2012 Chau DM, Crump CJ, Villa JC, Scheinberg DA, Li YM. Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase. The Journal of Biological Chemistry. 287: 17288-96. PMID 22461631 DOI: 10.1074/Jbc.M111.300483  0.436
2012 Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000. PMID 22418280 DOI: 10.1016/J.Bmcl.2012.02.027  0.385
2012 Li Y. Gamma-secretase: from pathogenesis to therapeutics. Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L4  0.423
2011 Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. Acs Chemical Neuroscience. 2: 705-710. PMID 22229075 DOI: 10.1021/Cn200098P  0.488
2011 Crump CJ, Johnson DS, Li YM. Target of γ-secretase modulators, presenilin marks the spot. The Embo Journal. 30: 4696-8. PMID 22126818 DOI: 10.1038/Emboj.2011.410  0.483
2011 Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/J.Cell.2011.09.036  0.35
2011 Antczak C, Shum D, Bassit B, Frattini MG, Li Y, de Stanchina E, Scheinberg DA, Djaballah H. Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorganic & Medicinal Chemistry Letters. 21: 4528-32. PMID 21719286 DOI: 10.1016/J.Bmcl.2011.05.129  0.346
2011 Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. The Journal of Biological Chemistry. 286: 21440-9. PMID 21454611 DOI: 10.1074/Jbc.M110.193326  0.433
2010 Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic gamma-secretase activity of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 107: 21435-40. PMID 21115843 DOI: 10.1073/Pnas.1013246107  0.475
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Li YM, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018  0.462
2010 Tian Y, Crump CJ, Li YM. Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production. The Journal of Biological Chemistry. 285: 32549-56. PMID 20675367 DOI: 10.1074/Jbc.M110.128439  0.471
2010 Placanica L, Chien JW, Li YM. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 49: 2796-804. PMID 20178366 DOI: 10.1021/Bi901388T  0.465
2009 Shelton CC, Tian Y, Shum D, Radu C, Djaballah H, Li YM. A miniaturized 1536-well format gamma-secretase assay. Assay and Drug Development Technologies. 7: 461-70. PMID 19715456 DOI: 10.1089/Adt.2009.0202  0.456
2009 Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA. Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. Journal of Molecular Biology. 387: 1211-28. PMID 19236878 DOI: 10.1016/J.Jmb.2009.02.032  0.391
2009 Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry. 284: 2967-77. PMID 19036728 DOI: 10.1074/Jbc.M807269200  0.478
2008 Lei X, Ahn K, Zhu L, Ubarretxena-Belandia I, Li YM. Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. Biochemistry. 47: 11920-9. PMID 18937501 DOI: 10.1021/Bi800385R  0.419
2008 Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200  0.396
2007 Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. The Journal of Biological Chemistry. 282: 23639-44. PMID 17556361 DOI: 10.1074/Jbc.M704601200  0.453
2007 Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. Journal of Biomolecular Screening. 12: 521-35. PMID 17435169 DOI: 10.1177/1087057107300463  0.34
2007 Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Molecular Neurodegeneration. 2: 4. PMID 17288597 DOI: 10.1186/1750-1326-2-4  0.449
2006 Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3845-54. PMID 16597739 DOI: 10.1523/Jneurosci.5384-05.2006  0.492
2005 Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, ... ... Li Y, et al. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells. Journal of Alzheimer's Disease : Jad. 7: 139-48; discussion 1. PMID 15851852 DOI: 10.3233/Jad-2005-7207  0.358
2005 Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, ... ... Li Y, et al. Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics. The Journal of Biological Chemistry. 280: 17792-7. PMID 15737955 DOI: 10.1074/jbc.M414331200  0.405
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  0.418
2004 Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proceedings of the National Academy of Sciences of the United States of America. 101: 17050-5. PMID 15563588 DOI: 10.1073/Pnas.0408007101  0.486
2004 Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. The Journal of Biological Chemistry. 279: 48615-9. PMID 15456788 DOI: 10.1074/Jbc.C400396200  0.455
2004 Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200  0.459
2004 Li Y, Tarassishin L, Yin Y, Bassit B. O2-03-06 Mechanism of gamma-secretase mediated APP and notch processing Neurobiology of Aging. 25: S37-S38. DOI: 10.1016/S0197-4580(04)80124-6  0.313
2003 Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochemical and Biophysical Research Communications. 312: 309-15. PMID 14637138 DOI: 10.1016/J.Bbrc.2003.10.123  0.363
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.501
2003 Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100  0.472
2003 Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity. The Journal of Biological Chemistry. 278: 21286-94. PMID 12665519 DOI: 10.1074/Jbc.M209859200  0.415
2000 Beher D, Li Y, Gardell SJ, Shearman MS. Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation Neurobiology of Aging. 21: 187. DOI: 10.1016/S0197-4580(00)82183-1  0.393
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