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Kiran V. Mahasenan, Ph.D. - Publications

Affiliations: 
2012 Pharmacy Ohio State University, Columbus, Columbus, OH 
Area:
Pharmacy
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR, Feltzer R, Mobashery S, Chang M. Exploration of the Structural Space in 4()-Quinazolinone Antibacterials. Journal of Medicinal Chemistry. PMID 32343145 DOI: 10.1021/Acs.Jmedchem.0C00153  0.371
2019 Alcorlo M, Dik DA, De Benedetti S, Mahasenan KV, Lee M, Domínguez-Gil T, Hesek D, Lastochkin E, López D, Boggess B, Mobashery S, Hermoso JA. Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division. Nature Communications. 10: 5567. PMID 31804467 DOI: 10.1038/S41467-019-13354-4  0.344
2019 Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant . Antimicrobial Agents and Chemotherapy. PMID 30858202 DOI: 10.1128/Aac.02637-18  0.387
2018 Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. Biochemistry. PMID 30256085 DOI: 10.1021/Acs.Biochem.8B00800  0.36
2018 Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. In Search of Selectivity in Inhibition of ADAM10. Acs Medicinal Chemistry Letters. 9: 708-713. PMID 30034605 DOI: 10.1021/Acsmedchemlett.8B00163  0.378
2018 Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Scientific Reports. 8: 4110. PMID 29515200 DOI: 10.1038/S41598-018-22527-Y  0.32
2018 Bernardo-Garcia N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. Acs Chemical Biology. PMID 29357220 DOI: 10.1021/Acschembio.7B00817  0.369
2018 Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S. Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt ofPseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 115: 4393-4398. DOI: 10.2210/Pdb6Fbt/Pdb  0.351
2017 Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. Acs Medicinal Chemistry Letters. 8: 654-659. PMID 28626528 DOI: 10.1021/Acsmedchemlett.7B00130  0.343
2017 Acebron I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S. Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 28482153 DOI: 10.1021/Jacs.7B01626  0.313
2017 Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S. Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis. Journal of the American Chemical Society. PMID 28099001 DOI: 10.1021/Jacs.6B12565  0.363
2017 Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF. Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure (London, England : 1993). PMID 28089449 DOI: 10.1016/J.Str.2016.12.007  0.336
2016 Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA. Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 27618662 DOI: 10.1016/J.Str.2016.07.019  0.345
2016 Lee M, Dominguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S. Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27035839 DOI: 10.1021/Acschembio.6B00194  0.321
2015 Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S. Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. Bioorganic & Medicinal Chemistry Letters. PMID 26733473 DOI: 10.1016/J.Bmcl.2015.12.041  0.366
2015 Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 125: 2530-43. PMID 25742700 DOI: 10.1182/Blood-2014-12-619783  0.479
2014 Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA. Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. Acs Chemical Biology. 9: 2058-66. PMID 24988330 DOI: 10.1021/Cb500439C  0.313
2014 Fu HL, Valiathan RR, Payne L, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Fridman R. Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1). The Journal of Biological Chemistry. 289: 9275-87. PMID 24509848 DOI: 10.1074/Jbc.M113.541102  0.344
2013 Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R. Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. The Journal of Biological Chemistry. 288: 7430-7. PMID 23335507 DOI: 10.1074/Jbc.R112.444158  0.304
2013 Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, et al. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of Natural Products. 76: 311-5. PMID 23167812 DOI: 10.1021/Np300638F  0.459
2013 Yan F, Gordon K, Mahasenan K, Lustberg M, Alinari L, Earl CT, Kaur B, Li C, Baiocchi RA. Abstract 4637: Developing a first in class of drug to inhibit protein arginine methyltransferase 5 (PRMT5) enzyme dysregulation in glioblastoma multiforme. Cancer Research. 73: 4637-4637. DOI: 10.1158/1538-7445.Am2013-4637  0.552
2013 Tarighat SS, Mahasenan K, Perrotti D, Garzon R, Caligiuri M, Li C, Blum W, Marcucci G, Baiocchi RA. Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia . Cancer Research. 73: 1128-1128. DOI: 10.1158/1538-7445.Am2013-1128  0.531
2012 Mahasenan KV, Li C. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example. Journal of Chemical Information and Modeling. 52: 1345-55. PMID 22540736 DOI: 10.1021/Ci300040C  0.508
2012 Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction. Acs Chemical Biology. 7: 761-9. PMID 22276994 DOI: 10.1021/Cb200450W  0.454
2011 Mahasenan KV, Pavlovicz RE, Henderson BJ, González-Cestari TF, Yi B, McKay DB, Li C. Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. Acs Medicinal Chemistry Letters. 2: 855-60. PMID 24936233 DOI: 10.1021/Ml2001714  0.495
2011 Henderson BJ, Carper DJ, González-Cestari TF, Yi B, Mahasenan K, Pavlovicz RE, Dalefield ML, Coleman RS, Li C, McKay DB. Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. Journal of Medicinal Chemistry. 54: 8681-92. PMID 22060139 DOI: 10.1021/Jm201294R  0.45
2011 Yan F, Smith P, Alinari L, Ryu J, Yu B, Karkhanis V, Tae S, Patton JT, Wilding EE, Gordon K, Mahasenan K, Bhasin D, Agostinelli C, Pileri SA, Byrd JC, et al. Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma Blood. 118: 595-595. DOI: 10.1182/Blood.V118.21.595.595  0.55
2011 Gu C, Mahasenan KV, Auvil T, Joshi K, Gupta S, Mattson A, Li C, Nakano I. Abstract 3298: Structure-based computer-aided drug design to discover novel small molecules that target brain tumor stem cells Cancer Research. 71: 3298-3298. DOI: 10.1158/1538-7445.Am2011-3298  0.354
2010 Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of Medicinal Chemistry. 53: 966-82. PMID 20047276 DOI: 10.1021/Jm900723W  0.466
2009 Tiwari R, Mahasenan K, Pavlovicz R, Li C, Tjarks W. Carborane clusters in computational drug design: a comparative docking evaluation using AutoDock, FlexX, Glide, and Surflex. Journal of Chemical Information and Modeling. 49: 1581-9. PMID 19449853 DOI: 10.1021/Ci900031Y  0.454
2007 George TG, Endeshaw MM, Morgan RE, Mahasenan KV, Delfín DA, Mukherjee MS, Yakovich AJ, Fotie J, Li C, Werbovetz KA. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorganic & Medicinal Chemistry. 15: 6071-9. PMID 17618122 DOI: 10.1016/J.Bmc.2007.06.042  0.475
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