| Year |
Citation |
Score |
| 2022 |
Bilyk O, Oliveira GS, de Angelo RM, Almeida MO, Honório KM, Leeper FJ, Dias MVB, Leadlay PF. Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis. Journal of the American Chemical Society. 144: 14555-14563. PMID 35921248 DOI: 10.1021/jacs.2c03313 |
0.305 |
|
| 2020 |
Little RF, Samborskyy M, Leadlay PF. The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic. Plos One. 15: e0239054. PMID 32925967 DOI: 10.1371/Journal.Pone.0239054 |
0.365 |
|
| 2020 |
Zhai G, Wang W, Xu W, Sun G, Hu C, Wu X, Cong Z, Deng L, Shi Y, Leadlay PF, Song H, Hong K, Deng Z, Sun Y. Cross-module Enoylreduction in the Azalomycin F Polyketide Synthase. Angewandte Chemie (International Ed. in English). PMID 32865309 DOI: 10.1002/Anie.202011357 |
0.371 |
|
| 2020 |
Shen Y, Sun F, Zhang L, Cheng Y, Zhu H, Wang SP, Jiao WH, Leadlay PF, Zhou Y, Lin HW. Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase. The Journal of Biological Chemistry. PMID 32165500 DOI: 10.1074/Jbc.Ra119.010922 |
0.384 |
|
| 2019 |
Koomsiri W, Inahashi Y, Leetanasaksakul K, Shiomi K, Takahashi YK, O Mura S, Samborskyy M, Leadlay PF, Wattana-Amorn P, Thamchaipenet A, Nakashima T. Sarpeptins A and B, Lipopeptides Produced by sp. KO-7888 Overexpressing a Specific SARP Regulator. Journal of Natural Products. PMID 31381320 DOI: 10.1021/Acs.Jnatprod.9B00074 |
0.352 |
|
| 2019 |
Bilyk O, Samborskyy M, Leadlay PF. The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety. Plos One. 14: e0215958. PMID 31039188 DOI: 10.1371/Journal.Pone.0215958 |
0.409 |
|
| 2019 |
de Araújo NC, Bury PDS, Tavares MT, Huang F, Parise Filho R, Leadlay P, Dias MVB. Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin. Acs Chemical Biology. PMID 30995396 DOI: 10.1021/Acschembio.9B00115 |
0.39 |
|
| 2019 |
Hong H, Samborskyy M, Zhou Y, Leadlay PF. C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A. Cell Chemical Biology. PMID 30713097 DOI: 10.1016/J.Chembiol.2018.12.004 |
0.405 |
|
| 2019 |
Häckh M, Lucas X, Marolt M, Leadlay PF, Müller M, Günther S, Lüdeke S. Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase. Chembiochem : a European Journal of Chemical Biology. PMID 30600894 DOI: 10.1002/Cbic.201800799 |
0.378 |
|
| 2019 |
Häckh M, Lucas X, Marolt M, Leadlay PF, Müller M, Günther S, Lüdeke S. Cover Feature: Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase (ChemBioChem 9/2019) Chembiochem. 20: 1090-1090. DOI: 10.1002/Cbic.201900222 |
0.322 |
|
| 2018 |
Zhou Y, Lin X, Williams SR, Liu L, Shen Y, Wang SP, Sun F, Xu S, Deng H, Leadlay PF, Lin HW. Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-dependent Reductase. Acs Chemical Biology. PMID 29979567 DOI: 10.1021/Acschembio.8B00325 |
0.399 |
|
| 2018 |
Li S, Guo J, Reva A, Huang F, Xiong B, Liu Y, Deng Z, Leadlay PF, Sun Y. Methyltransferases of gentamicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358400 DOI: 10.1073/Pnas.1711603115 |
0.368 |
|
| 2017 |
Hong H, Samborskyy M, Usachova K, Schnatz K, Leadlay PF. Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes. Beilstein Journal of Organic Chemistry. 13: 2408-2415. PMID 29234468 DOI: 10.17863/Cam.20366 |
0.36 |
|
| 2017 |
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, ... ... Leadlay PF, et al. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. Nature Communications. 8: 1206. PMID 29089518 DOI: 10.1038/S41467-017-01344-3 |
0.662 |
|
| 2017 |
Bury PDS, Huang F, Li S, Sun Y, Leadlay PF, Dias MVB. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-methyltransferase Involved in Gentamicin Biosynthesis. Acs Chemical Biology. PMID 28876898 DOI: 10.1021/Acschembio.7B00466 |
0.391 |
|
| 2017 |
Xu W, Zhai G, Liu Y, Li Y, Shi Y, Hong K, Hong H, Leadlay PF, Deng Z, Sun Y. An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain. Angewandte Chemie (International Ed. in English). PMID 28418225 DOI: 10.1002/Anie.201701220 |
0.36 |
|
| 2017 |
Rabe P, Samborskyy M, Leadlay PF, Dickschat JS. Isoafricanol synthase from Streptomyces malaysiensis. Organic & Biomolecular Chemistry. PMID 28247907 DOI: 10.1039/C7Ob00234C |
0.548 |
|
| 2017 |
Yurkovich ME, Jenkins R, Sun Y, Tosin M, Leadlay PF. The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase. Chemical Communications (Cambridge, England). PMID 28124037 DOI: 10.1039/C6Cc09934C |
0.337 |
|
| 2017 |
Havemann J, Yurkovich ME, Jenkins R, Harringer S, Tao W, Wen S, Sun Y, Leadlay PF, Tosin M. Chemical probing of thiotetronate bio-assembly. Chemical Communications (Cambridge, England). PMID 28119973 DOI: 10.1039/C6Cc09933E |
0.338 |
|
| 2016 |
Tao W, Yurkovich ME, Wen S, Lebe KE, Samborskyy M, Liu Y, Yang A, Liu Y, Ju Y, Deng Z, Tosin M, Sun Y, Leadlay PF. A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chemical Science. 7: 376-385. PMID 28791099 DOI: 10.1039/C5Sc03059E |
0.393 |
|
| 2016 |
Hong H, Sun Y, Zhou Y, Stephens E, Samborskyy M, Leadlay PF. Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase. Beilstein Journal of Organic Chemistry. 12: 2164-2172. PMID 27829923 DOI: 10.3762/Bjoc.12.206 |
0.416 |
|
| 2016 |
Murphy AC, Hong H, Vance S, Broadhurst RW, Leadlay PF. Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation. Chemical Communications (Cambridge, England). PMID 27307197 DOI: 10.1039/C6Cc03501A |
0.368 |
|
| 2016 |
Netzker T, Schroeckh V, Gregory MA, Flak M, Krespach MK, Leadlay PF, Brakhage AA. An efficient method to generate gene deletion mutants of the rapamycin producing bacterium Streptomyces iranensis HM 35. Applied and Environmental Microbiology. PMID 27037115 DOI: 10.1128/Aem.00371-16 |
0.362 |
|
| 2016 |
Parascandolo JS, Havemann J, Potter HK, Huang F, Riva E, Connolly J, Wilkening I, Song L, Leadlay PF, Tosin M. Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes. Angewandte Chemie (International Ed. in English). PMID 26833898 DOI: 10.1002/Anie.201509038 |
0.403 |
|
| 2015 |
Hong H, Samborskyy M, Lindner F, Leadlay PF. An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics. Angewandte Chemie (International Ed. in English). PMID 26630438 DOI: 10.1002/Anie.201509300 |
0.42 |
|
| 2015 |
Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF. Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 26377145 DOI: 10.1002/Anie.201507090 |
0.399 |
|
| 2015 |
Zhou Y, Murphy AC, Samborskyy M, Prediger P, Dias LC, Leadlay PF. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin. Chemistry & Biology. 22: 745-54. PMID 26091168 DOI: 10.1016/J.Chembiol.2015.05.010 |
0.386 |
|
| 2015 |
Annaval T, Paris C, Leadlay PF, Jacob C, Weissman KJ. Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry. Chembiochem : a European Journal of Chemical Biology. 16: 1357-64. PMID 25851784 DOI: 10.1002/Cbic.201500113 |
0.334 |
|
| 2015 |
Zhou Y, Prediger P, Dias LC, Murphy AC, Leadlay PF. Macrodiolide formation by the thioesterase of a modular polyketide synthase. Angewandte Chemie (International Ed. in English). 54: 5232-5. PMID 25753953 DOI: 10.1002/Anie.201500401 |
0.379 |
|
| 2015 |
Huang C, Huang F, Moison E, Guo J, Jian X, Duan X, Deng Z, Leadlay PF, Sun Y. Delineating the biosynthesis of gentamicin x2, the common precursor of the gentamicin C antibiotic complex. Chemistry & Biology. 22: 251-61. PMID 25641167 DOI: 10.1016/J.Chembiol.2014.12.012 |
0.35 |
|
| 2014 |
Riva E, Wilkening I, Gazzola S, Li WM, Smith L, Leadlay PF, Tosin M. Chemical probes for the functionalization of polyketide intermediates. Angewandte Chemie (International Ed. in English). 53: 11944-9. PMID 25212788 DOI: 10.1002/Anie.201407448 |
0.36 |
|
| 2014 |
Luhavaya H, Williams SR, Hong H, Gonzaga de Oliveira L, Leadlay PF. Site-specific modification of the anticancer and antituberculosis polyether salinomycin by biosynthetic engineering. Chembiochem : a European Journal of Chemical Biology. 15: 2081-5. PMID 25155178 DOI: 10.1002/Cbic.201402300 |
0.348 |
|
| 2014 |
Leadlay PF. Structural biology: enzyme assembly line pictured. Nature. 510: 482-3. PMID 24965648 DOI: 10.1038/Nature13505 |
0.326 |
|
| 2014 |
Vieweg L, Reichau S, Schobert R, Leadlay PF, Süssmuth RD. Recent advances in the field of bioactive tetronates. Natural Product Reports. 31: 1554-84. PMID 24965099 DOI: 10.1039/C4Np00015C |
0.302 |
|
| 2014 |
Hahn F, Kandziora N, Friedrich S, Leadlay PF. Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis. Beilstein Journal of Organic Chemistry. 10: 634-40. PMID 24778714 DOI: 10.3762/Bjoc.10.55 |
0.571 |
|
| 2014 |
Guo J, Huang F, Huang C, Duan X, Jian X, Leeper F, Deng Z, Leadlay PF, Sun Y. Specificity and promiscuity at the branch point in gentamicin biosynthesis. Chemistry & Biology. 21: 608-18. PMID 24746560 DOI: 10.1016/J.Chembiol.2014.03.005 |
0.363 |
|
| 2014 |
Hüttel W, Spencer JB, Leadlay PF. Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8. PMID 24605157 DOI: 10.3762/Bjoc.10.34 |
0.338 |
|
| 2014 |
Kandziora N, Andexer JN, Moss SJ, Wilkinson B, Leadlay PF, Hahn F. Uncovering the origin of Z-configured double bonds in polyketides: Intermediate E-double bond formation during borrelidin biosynthesis Chemical Science. 5: 3563-3567. DOI: 10.1039/C4Sc00883A |
0.544 |
|
| 2013 |
Hong H, Fill T, Leadlay PF. A common origin for guanidinobutanoate starter units in antifungal natural products. Angewandte Chemie (International Ed. in English). 52: 13096-9. PMID 24218293 DOI: 10.1002/Anie.201308136 |
0.341 |
|
| 2013 |
Porter JL, Tobias NJ, Pidot SJ, Falgner S, Tuck KL, Vettiger A, Hong H, Leadlay PF, Stinear TP. The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis. Plos One. 8: e70520. PMID 23894666 DOI: 10.1371/Journal.Pone.0070520 |
0.379 |
|
| 2013 |
Kanchanabanca C, Tao W, Hong H, Liu Y, Hahn F, Samborskyy M, Deng Z, Sun Y, Leadlay PF. Unusual acetylation-elimination in the formation of tetronate antibiotics. Angewandte Chemie (International Ed. in English). 52: 5785-8. PMID 23606658 DOI: 10.1002/Anie.201301680 |
0.515 |
|
| 2012 |
Herrmann S, Siegl T, Luzhetska M, Petzke L, Jilg C, Welle E, Erb A, Leadlay PF, Bechthold A, Luzhetskyy A. Site-specific recombination strategies for engineering actinomycete genomes. Applied and Environmental Microbiology. 78: 1804-12. PMID 22247163 DOI: 10.1128/Aem.06054-11 |
0.32 |
|
| 2012 |
Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF. Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII. Journal of Molecular Biology. 415: 92-101. PMID 22056329 DOI: 10.1016/J.Jmb.2011.10.036 |
0.321 |
|
| 2011 |
Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science (Royal Society of Chemistry : 2010). 2011: 273-278. PMID 22822423 DOI: 10.1039/C0Sc00297F |
0.618 |
|
| 2011 |
Tosin M, Smith L, Leadlay PF. Insights into lasalocid A ring formation by chemical chain termination in vivo. Angewandte Chemie (International Ed. in English). 50: 11930-3. PMID 22025396 DOI: 10.1002/Anie.201106323 |
0.331 |
|
| 2011 |
Dickschat JS, Vergnolle O, Hong H, Garner S, Bidgood SR, Dooley HC, Deng Z, Leadlay PF, Sun Y. An additional dehydratase-like activity is required for lankacidin antibiotic biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 2408-12. PMID 21953738 DOI: 10.1002/Cbic.201100474 |
0.54 |
|
| 2011 |
Vergnolle O, Hahn F, Baerga-Ortiz A, Leadlay PF, Andexer JN. Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation. Chembiochem : a European Journal of Chemical Biology. 12: 1011-4. PMID 21472957 DOI: 10.1002/Cbic.201100011 |
0.528 |
|
| 2011 |
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, ... Leadlay PF, et al. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proceedings of the National Academy of Sciences of the United States of America. 108: 4776-81. PMID 21383123 DOI: 10.1073/Pnas.1015773108 |
0.675 |
|
| 2011 |
Kwan DH, Tosin M, Schläger N, Schulz F, Leadlay PF. Insights into the stereospecificity of ketoreduction in a modular polyketide synthase. Organic & Biomolecular Chemistry. 9: 2053-6. PMID 21340070 DOI: 10.1039/C1Ob00022E |
0.796 |
|
| 2010 |
Magdevska V, Gaber R, GoranoviÄ D, KuÅ¡Äer E, Boakes S, Durán Alonso MB, SantamarÃa RI, Raspor P, Leadlay PF, Fujs S, Petković H. Robust reporter system based on chalcone synthase rppA gene from Saccharopolyspora erythraea. Journal of Microbiological Methods. 83: 111-9. PMID 20709115 DOI: 10.1016/J.Mimet.2010.08.001 |
0.316 |
|
| 2010 |
Kwan DH, Leadlay PF. Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity. Acs Chemical Biology. 5: 829-38. PMID 20666435 DOI: 10.1021/Cb100175A |
0.748 |
|
| 2010 |
Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/Jbc.M110.107177 |
0.378 |
|
| 2010 |
Lazos O, Tosin M, Slusarczyk AL, Boakes S, Cortés J, Sidebottom PJ, Leadlay PF. Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters. Chemistry & Biology. 17: 160-73. PMID 20189106 DOI: 10.1016/J.Chembiol.2010.01.011 |
0.31 |
|
| 2010 |
Tosin M, Betancor L, Stephens E, Li WM, Spencer JB, Leadlay PF. Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46. PMID 20135665 DOI: 10.1002/Cbic.200900772 |
0.361 |
|
| 2010 |
Sun Y, Hahn F, Demydchuk Y, Chettle J, Tosin M, Osada H, Leadlay PF. In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chemical Biology. 6: 99-101. PMID 20081823 DOI: 10.1038/Nchembio.285 |
0.603 |
|
| 2009 |
Hong H, Leadlay PF, Staunton J. The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry. The Febs Journal. 276: 7057-69. PMID 19860832 DOI: 10.1111/J.1742-4658.2009.07418.X |
0.56 |
|
| 2008 |
Smith L, Hong H, Spencer JB, Leadlay PF. Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75. PMID 19025863 DOI: 10.1002/Cbic.200800585 |
0.393 |
|
| 2008 |
Kwan DH, Sun Y, Schulz F, Hong H, Popovic B, Sim-Stark JC, Haydock SF, Leadlay PF. Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chemistry & Biology. 15: 1231-40. PMID 19022183 DOI: 10.1016/J.Chembiol.2008.09.012 |
0.782 |
|
| 2008 |
Betancor L, Fernández MJ, Weissman KJ, Leadlay PF. Improved catalytic activity of a purified multienzyme from a modular polyketide synthase after coexpression with Streptomyces chaperonins in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 9: 2962-6. PMID 19021139 DOI: 10.1002/Cbic.200800475 |
0.344 |
|
| 2008 |
Kellenberger L, Galloway IS, Sauter G, Böhm G, Hanefeld U, Cortés J, Staunton J, Leadlay PF. A polylinker approach to reductive loop swaps in modular polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 9: 2740-9. PMID 18937219 DOI: 10.1002/Cbic.200800332 |
0.573 |
|
| 2008 |
Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP. Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. Bmc Genomics. 9: 462. PMID 18840298 DOI: 10.1186/1471-2164-9-462 |
0.372 |
|
| 2008 |
Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S. Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. Organic & Biomolecular Chemistry. 6: 3315-27. PMID 18802638 DOI: 10.1039/B807914E |
0.634 |
|
| 2008 |
Fan Q, Huang F, Leadlay PF, Spencer JB. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14. PMID 18802637 DOI: 10.1039/B808734B |
0.402 |
|
| 2008 |
Truman AW, Fan Q, Röttgen M, Stegmann E, Leadlay PF, Spencer JB. The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function. Chemistry & Biology. 15: 476-84. PMID 18482700 DOI: 10.1016/J.Chembiol.2008.03.019 |
0.384 |
|
| 2008 |
Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45. PMID 18404760 DOI: 10.1002/Cbic.200700715 |
0.562 |
|
| 2008 |
Tran L, Tosin M, Spencer JB, Leadlay PF, Weissman KJ. Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 9: 905-15. PMID 18348128 DOI: 10.1002/Cbic.200700738 |
0.33 |
|
| 2008 |
Petkovi? H, Sandmann A, Challis IR, Hecht HJ, Silakowski B, Low L, Beeston N, Kuscer E, Garcia-Bernardo J, Leadlay PF, Kendrew SG, Wilkinson B, Müller R. Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase. Organic & Biomolecular Chemistry. 6: 500-6. PMID 18219420 DOI: 10.1039/B714804F |
0.711 |
|
| 2008 |
Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF. Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem : a European Journal of Chemical Biology. 9: 150-6. PMID 18046685 DOI: 10.1002/Cbic.200700492 |
0.414 |
|
| 2007 |
Harvey BM, Mironenko T, Sun Y, Hong H, Deng Z, Leadlay PF, Weissman KJ, Haydock SF. Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chemistry & Biology. 14: 703-14. PMID 17584617 DOI: 10.1016/J.Chembiol.2007.05.011 |
0.333 |
|
| 2007 |
Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF, Leadlay PF. Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nature Biotechnology. 25: 447-53. PMID 17369815 DOI: 10.1038/Nbt1297 |
0.326 |
|
| 2006 |
Sheehan LS, Lill RE, Wilkinson B, Sheridan RM, Vousden WA, Kaja AL, Crouse GD, Gifford J, Graupner PR, Karr L, Lewer P, Sparks TC, Leadlay PF, Waldron C, Martin CJ. Engineering of the spinosyn PKS: directing starter unit incorporation. Journal of Natural Products. 69: 1702-10. PMID 17190446 DOI: 10.1021/Np0602517 |
0.638 |
|
| 2006 |
Sun Y, Hong H, Samborskyy M, Samboskyy M, Mironenko T, Leadlay PF, Haydock SF. Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin. Microbiology (Reading, England). 152: 3507-15. PMID 17159202 DOI: 10.1099/Mic.0.29176-0 |
0.355 |
|
| 2006 |
Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, et al. Rapamycin biosynthesis: Elucidation of gene product function. Organic & Biomolecular Chemistry. 4: 3565-8. PMID 16990929 DOI: 10.1039/B608813A |
0.627 |
|
| 2006 |
Wilkinson B, Gregory MA, Moss SJ, Carletti I, Sheridan RM, Kaja A, Ward M, Olano C, Mendez C, Salas JA, Leadlay PF, vanGinckel R, Zhang MQ. Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorganic & Medicinal Chemistry Letters. 16: 5814-7. PMID 16962775 DOI: 10.1016/J.Bmcl.2006.08.073 |
0.621 |
|
| 2006 |
Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42. PMID 16897798 DOI: 10.1002/Cbic.200500474 |
0.587 |
|
| 2006 |
Moss SJ, Carletti I, Olano C, Sheridan RM, Ward M, Math V, Nur-E-Alam M, Braña AF, Zhang MQ, Leadlay PF, Méndez C, Salas JA, Wilkinson B. Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. Chemical Communications (Cambridge, England). 2341-3. PMID 16733573 DOI: 10.1039/B602931K |
0.605 |
|
| 2006 |
Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chemistry & Biology. 13: 475-84. PMID 16720268 DOI: 10.1016/J.Chembiol.2006.02.014 |
0.424 |
|
| 2006 |
O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 287-96. PMID 16638534 DOI: 10.1016/J.Chembiol.2006.01.003 |
0.412 |
|
| 2006 |
Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 277-85. PMID 16638533 DOI: 10.1016/J.Chembiol.2006.01.004 |
0.363 |
|
| 2006 |
Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB. Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60. PMID 16632258 DOI: 10.1016/J.Chembiol.2006.01.013 |
0.593 |
|
| 2005 |
Weissman KJ, Leadlay PF. Combinatorial biosynthesis of reduced polyketides. Nature Reviews. Microbiology. 3: 925-36. PMID 16322741 DOI: 10.1038/Nrmicro1287 |
0.364 |
|
| 2005 |
Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53. PMID 16242657 DOI: 10.1016/J.Chembiol.2005.08.017 |
0.59 |
|
| 2005 |
Bhatt A, Stark CB, Harvey BM, Gallimore AR, Demydchuk YA, Spencer JB, Staunton J, Leadlay PF. Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angewandte Chemie (International Ed. in English). 44: 7075-8. PMID 16217816 DOI: 10.1002/Anie.200501757 |
0.454 |
|
| 2005 |
Haydock SF, Appleyard AN, Mironenko T, Lester J, Scott N, Leadlay PF. Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. Microbiology (Reading, England). 151: 3161-9. PMID 16207901 DOI: 10.1099/Mic.0.28194-0 |
0.39 |
|
| 2005 |
Gregory MA, Petkovic H, Lill RE, Moss SJ, Wilkinson B, Gaisser S, Leadlay PF, Sheridan RM. Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angewandte Chemie (International Ed. in English). 44: 4757-60. PMID 15977283 DOI: 10.1002/Anie.200462784 |
0.615 |
|
| 2005 |
Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF. Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry. The Febs Journal. 272: 2373-87. PMID 15885088 DOI: 10.1111/J.1742-4658.2005.04615.X |
0.548 |
|
| 2005 |
Stinear TP, Hong H, Frigui W, Pryor MJ, Brosch R, Garnier T, Leadlay PF, Cole ST. Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. Journal of Bacteriology. 187: 1668-76. PMID 15716437 DOI: 10.1128/Jb.187.5.1668-1676.2005 |
0.31 |
|
| 2004 |
Boakes S, Oliynyk M, Cortés J, Böhm I, Rudd BA, Revill WP, Staunton J, Leadlay PF. A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. Journal of Molecular Microbiology and Biotechnology. 8: 73-80. PMID 15925898 DOI: 10.1159/000084562 |
0.585 |
|
| 2004 |
Haydock SF, Mironenko T, Ghoorahoo HI, Leadlay PF. The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin. Journal of Biotechnology. 113: 55-68. PMID 15380647 DOI: 10.1016/J.Jbiotec.2004.03.022 |
0.351 |
|
| 2004 |
Olano C, Moss SJ, Braña AF, Sheridan RM, Math V, Weston AJ, Méndez C, Leadlay PF, Wilkinson B, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Molecular Microbiology. 52: 1745-56. PMID 15186422 DOI: 10.1111/J.1365-2958.2004.04090.X |
0.669 |
|
| 2004 |
Lowden PA, Böhm GA, Metcalfe S, Staunton J, Leadlay PF. New rapamycin derivatives by precursor-directed biosynthesis. Chembiochem : a European Journal of Chemical Biology. 5: 535-8. PMID 15185378 DOI: 10.1002/Cbic.200300758 |
0.496 |
|
| 2004 |
Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus. Angewandte Chemie (International Ed. in English). 43: 2551-3. PMID 15127450 DOI: 10.1002/Anie.200453764 |
0.681 |
|
| 2004 |
Li TL, Huang F, Haydock SF, Mironenko T, Leadlay PF, Spencer JB. Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chemistry & Biology. 11: 107-19. PMID 15113000 DOI: 10.1016/J.Chembiol.2004.01.001 |
0.36 |
|
| 2004 |
Olano C, Wilkinson B, Sánchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Braña AF, Martin CJ, Oliynyk M, Méndez C, Leadlay PF, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chemistry & Biology. 11: 87-97. PMID 15112998 DOI: 10.1016/J.Chembiol.2003.12.018 |
0.651 |
|
| 2004 |
Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST. Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proceedings of the National Academy of Sciences of the United States of America. 101: 1345-9. PMID 14736915 DOI: 10.1073/Pnas.0305877101 |
0.392 |
|
| 2004 |
Weissman KJ, Hong H, Oliynyk M, Siskos AP, Leadlay PF. Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. Chembiochem : a European Journal of Chemical Biology. 5: 116-25. PMID 14695521 DOI: 10.1002/Cbic.200300775 |
0.377 |
|
| 2004 |
Gregory M, Gaisser S, Lill R, Hong H, Wilkinson B, Petkovic H, Sheridan R, Staunton J, Leadlay P, Zhang M. 566 Novel mTOR inhibitors with improved pharmacological properties over rapamycin European Journal of Cancer Supplements. 2: 172. DOI: 10.1016/S1359-6349(04)80574-3 |
0.39 |
|
| 2003 |
Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Organic & Biomolecular Chemistry. 1: 4144-7. PMID 14685317 DOI: 10.1039/B310740J |
0.722 |
|
| 2003 |
Hong H, Gates PJ, Staunton J, Stinear T, Cole ST, Leadlay PF, Spencer JB. Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. Chemical Communications (Cambridge, England). 2822-3. PMID 14651122 DOI: 10.1039/B308163J |
0.506 |
|
| 2003 |
Olano C, Wilkinson B, Moss SJ, Braña AF, Méndez C, Leadlay PF, Salas JA. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chemical Communications (Cambridge, England). 2780-2. PMID 14651102 DOI: 10.1039/B310648A |
0.612 |
|
| 2003 |
Squire CM, Goss RJ, Hong H, Leadlay PF, Staunton J. Catalytically active tetramodular 6-deoxyerythonolide B synthase fusion proteins. Chembiochem : a European Journal of Chemical Biology. 4: 1225-8. PMID 14613116 DOI: 10.1002/Cbic.200300671 |
0.493 |
|
| 2003 |
Hughes-Thomas ZA, Stark CB, Böhm IU, Staunton J, Leadlay PF. Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization. Angewandte Chemie (International Ed. in English). 42: 4475-8. PMID 14520742 DOI: 10.1002/Anie.200351375 |
0.487 |
|
| 2003 |
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Organic & Biomolecular Chemistry. 1: 2840-7. PMID 12968333 DOI: 10.1039/B304022D |
0.694 |
|
| 2003 |
Broadhurst RW, Nietlispach D, Wheatcroft MP, Leadlay PF, Weissman KJ. The structure of docking domains in modular polyketide synthases. Chemistry & Biology. 10: 723-31. PMID 12954331 DOI: 10.1016/S1074-5521(03)00156-X |
0.396 |
|
| 2003 |
Oliynyk M, Stark CB, Bhatt A, Jones MA, Hughes-Thomas ZA, Wilkinson C, Oliynyk Z, Demydchuk Y, Staunton J, Leadlay PF. Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. Molecular Microbiology. 49: 1179-90. PMID 12940979 DOI: 10.1046/J.1365-2958.2003.03571.X |
0.577 |
|
| 2003 |
Petkovic H, Lill RE, Sheridan RM, Wilkinson B, McCormick EL, McArthur HA, Staunton J, Leadlay PF, Kendrew SG. A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase. The Journal of Antibiotics. 56: 543-51. PMID 12931864 DOI: 10.7164/Antibiotics.56.543 |
0.714 |
|
| 2003 |
Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Active-site residue, domain and module swaps in modular polyketide synthases. Journal of Industrial Microbiology & Biotechnology. 30: 489-94. PMID 12811585 DOI: 10.1007/S10295-003-0062-0 |
0.712 |
|
| 2002 |
Thomas I, Martin CJ, Wilkinson CJ, Staunton J, Leadlay PF. Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer. Chemistry & Biology. 9: 781-7. PMID 12144921 DOI: 10.1016/S1074-5521(02)00164-3 |
0.559 |
|
| 2002 |
Wilkinson CJ, Hughes-Thomas ZA, Martin CJ, Böhm I, Mironenko T, Deacon M, Wheatcroft M, Wirtz G, Staunton J, Leadlay PF. Increasing the efficiency of heterologous promoters in actinomycetes. Journal of Molecular Microbiology and Biotechnology. 4: 417-26. PMID 12125822 |
0.47 |
|
| 2002 |
Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, Staunton J. Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chemical Communications (Cambridge, England). 618-9. PMID 12120151 DOI: 10.1039/B200536K |
0.673 |
|
| 2002 |
Gaisser S, Lill R, Staunton J, Méndez C, Salas J, Leadlay PF. Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. Molecular Microbiology. 44: 771-81. PMID 11994157 DOI: 10.1046/J.1365-2958.2002.02910.X |
0.503 |
|
| 2002 |
Long PF, Wilkinson CJ, Bisang CP, Cortés J, Dunster N, Oliynyk M, McCormick E, McArthur H, Mendez C, Salas JA, Staunton J, Leadlay PF. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Molecular Microbiology. 43: 1215-25. PMID 11918808 DOI: 10.1046/J.1365-2958.2002.02815.X |
0.57 |
|
| 2002 |
Østergaard LH, Kellenberger L, Cortés J, Roddis MP, Deacon M, Staunton J, Leadlay PF. Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. Biochemistry. 41: 2719-26. PMID 11851419 DOI: 10.1021/Bi0117605 |
0.585 |
|
| 2002 |
Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, Bechthold A. Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1. Microbiology (Reading, England). 148: 373-9. PMID 11832501 DOI: 10.1099/00221287-148-2-373 |
0.344 |
|
| 2002 |
Kaur H, Cortes J, Leadlay P, Lal R. Cloning and partial characterization of the putative rifamycin biosynthetic gene cluster from the actinomycete Amycolatopsis mediterranei DSM 46095. Microbiological Research. 156: 239-46. PMID 11716212 DOI: 10.1078/0944-5013-00108 |
0.303 |
|
| 2002 |
Hong H, Østergaard L, Heathcote ML, Staunton J, Leadlay PF. Investigation of malfunction in an engineered polyketide synthase by proteolysis and LC-MS Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 355-356. |
0.397 |
|
| 2001 |
Leadlay PF, Staunton J, Oliynyk M, Bisang C, Cortés J, Frost E, Hughes-Thomas ZA, Jones MA, Kendrew SG, Lester JB, Long PF, McArthur HA, McCormick EL, Oliynyk Z, Stark CB, et al. Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster. Journal of Industrial Microbiology & Biotechnology. 27: 360-7. PMID 11774001 DOI: 10.1038/Sj.Jim.7000204 |
0.593 |
|
| 2001 |
Wilkinson CJ, Frost EJ, Staunton J, Leadlay PF. Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum. Chemistry & Biology. 8: 1197-208. PMID 11755398 DOI: 10.1016/S1074-5521(01)00087-4 |
0.583 |
|
| 2001 |
Gaisser S, Lill R, Wirtz G, Grolle F, Staunton J, Leadlay PF. New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. Molecular Microbiology. 41: 1223-31. PMID 11555300 DOI: 10.1046/J.1365-2958.2001.02594.X |
0.494 |
|
| 2001 |
Rowe CJ, Böhm IU, Thomas IP, Wilkinson B, Rudd BA, Foster G, Blackaby AP, Sidebottom PJ, Roddis Y, Buss AD, Staunton J, Leadlay PF. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chemistry & Biology. 8: 475-85. PMID 11358694 DOI: 10.1016/S1074-5521(01)00024-2 |
0.596 |
|
| 2001 |
Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJ, Reather JA, Rudd BA, Staunton J, Leadlay PF. Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates. Chemistry & Biology. 8: 329-40. PMID 11325589 DOI: 10.1016/S1074-5521(01)00014-X |
0.592 |
|
| 2001 |
Heathcote ML, Staunton J, Leadlay PF. Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units. Chemistry & Biology. 8: 207-20. PMID 11251294 DOI: 10.1016/S1074-5521(01)00002-3 |
0.552 |
|
| 2001 |
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.). Angewandte Chemie (International Ed. in English). 40: 777-779. PMID 11241621 DOI: 10.1002/1521-3773(20010216)40:4<777::Aid-Anie7770>3.0.Co;2-9 |
0.709 |
|
| 2000 |
Thomä NH, Evans PR, Leadlay PF. Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry. 39: 9213-21. PMID 10924114 DOI: 10.1021/Bi0004302 |
0.664 |
|
| 2000 |
Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton J, Leadlay PF. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Molecular Microbiology. 36: 391-401. PMID 10792725 DOI: 10.1046/J.1365-2958.2000.01856.X |
0.563 |
|
| 2000 |
Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, Staunton J. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chemistry & Biology. 7: 111-7. PMID 10662692 DOI: 10.1016/S1074-5521(00)00076-4 |
0.592 |
|
| 2000 |
Bycroft M, Weissman KJ, Staunton J, Leadlay PF. Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase. European Journal of Biochemistry / Febs. 267: 520-6. PMID 10632721 DOI: 10.1046/J.1432-1327.2000.01025.X |
0.586 |
|
| 1999 |
Weissman KJ, Kearney GC, Leadlay PF, Staunton J. Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry Rapid Communications in Mass Spectrometry : Rcm. 13: 2103-8. PMID 10523767 DOI: 10.1002/(Sici)1097-0231(19991115)13:21<2103::Aid-Rcm760>3.0.Co;2-Y |
0.472 |
|
| 1999 |
Bisang C, Long PF, Cortés J, Westcott J, Crosby J, Matharu AL, Cox RJ, Simpson TJ, Staunton J, Leadlay PF. A chain initiation factor common to both modular and aromatic polyketide synthases. Nature. 401: 502-5. PMID 10519556 DOI: 10.1038/46829 |
0.548 |
|
| 1999 |
Ranganathan A, Timoney M, Bycroft M, Cortés J, Thomas IP, Wilkinson B, Kellenberger L, Hanefeld U, Galloway IS, Staunton J, Leadlay PF. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues. Chemistry & Biology. 6: 731-41. PMID 10508677 DOI: 10.1016/S1074-5521(00)80020-4 |
0.565 |
|
| 1999 |
Kearney GC, Gates PJ, Leadlay PF, Staunton J, Jones R. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II. Rapid Communications in Mass Spectrometry : Rcm. 13: 1650-6. PMID 10440983 DOI: 10.1002/(SICI)1097-0231(19990830)13:16<1650::AID-RCM693>3.0.CO;2-8 |
0.406 |
|
| 1999 |
Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BA, Leadlay PF. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase. Chemistry & Biology. 6: 189-95. PMID 10099131 DOI: 10.1016/S1074-5521(99)80035-0 |
0.566 |
|
| 1999 |
Gates PJ, Kearney GC, Jones R, Leadlay PF, Staunton J. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 13: 242-6. PMID 10097401 DOI: 10.1002/(Sici)1097-0231(19990228)13:4<242::Aid-Rcm447>3.0.Co;2-B |
0.487 |
|
| 1998 |
Weissman KJ, Smith CJ, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay PF. The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates. Angewandte Chemie (International Ed. in English). 37: 1437-1440. PMID 29710889 DOI: 10.1002/(Sici)1521-3773(19980605)37:10<1437::Aid-Anie1437>3.0.Co;2-7 |
0.585 |
|
| 1998 |
Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ. Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. The Journal of Antibiotics. 51: 1029-34. PMID 9918396 DOI: 10.7164/Antibiotics.51.1029 |
0.543 |
|
| 1998 |
Weissman KJ, Bycroft M, Cutter AL, Hanefeld U, Frost EJ, Timoney MC, Harris R, Handa S, Roddis M, Staunton J, Leadlay PF. Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase. Chemistry & Biology. 5: 743-54. PMID 9862800 DOI: 10.1016/S1074-5521(98)90666-4 |
0.587 |
|
| 1998 |
Thomä NH, Meier TW, Evans PR, Leadlay PF. Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase. Biochemistry. 37: 14386-93. PMID 9772164 DOI: 10.1021/Bi981375O |
0.67 |
|
| 1998 |
Thoma NH, Leadlay PF. 665th Meeting, University of Southampton, United Kingdom, 31 March - 2 April 1998: Structure and mechanism of enzymes: Mechanistic and structural studies on methylmalonyl-CoA mutase Biochemical Society Transactions. 26: 293-298. PMID 9765867 DOI: 10.1042/Bst0260293 |
0.631 |
|
| 1998 |
Celis RTF, Leadlay PF, Roy I, Hansen A. Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system Journal of Bacteriology. 180: 4828-4833. PMID 9733684 DOI: 10.1128/Jb.180.18.4828-4833.1998 |
0.301 |
|
| 1998 |
Rowe CJ, Cortés J, Gaisser S, Staunton J, Leadlay PF. Construction of new vectors for high-level expression in actinomycetes. Gene. 216: 215-23. PMID 9714812 DOI: 10.1016/S0378-1119(98)00327-8 |
0.555 |
|
| 1998 |
Böhm I, Holzbaur IE, Hanefeld U, Cortés J, Staunton J, Leadlay PF. Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension. Chemistry & Biology. 5: 407-12. PMID 9710562 DOI: 10.1016/S1074-5521(98)90157-0 |
0.593 |
|
| 1998 |
Weissman KJ, Bycroft M, Staunton J, Leadlay PF. Origin of starter units for erythromycin biosynthesis. Biochemistry. 37: 11012-7. PMID 9692995 DOI: 10.1021/Bi9806246 |
0.608 |
|
| 1998 |
Gaisser S, Böhm GA, Doumith M, Raynal MC, Dhillon N, Cortés J, Leadlay PF. Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea Molecular and General Genetics. 258: 78-88. PMID 9613575 DOI: 10.1007/S004380050709 |
0.369 |
|
| 1998 |
Salah-Bey K, Doumith M, Michel JM, Haydock S, Cortés J, Leadlay PF, Raynal MC. Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea Molecular and General Genetics. 257: 542-553. PMID 9563840 DOI: 10.1007/S004380050680 |
0.396 |
|
| 1998 |
Khaw LE, Böhm GA, Metcalfe S, Staunton J, Leadlay PF. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. Journal of Bacteriology. 180: 809-14. PMID 9473033 DOI: 10.1128/Jb.180.4.809-814.1998 |
0.562 |
|
| 1998 |
Marsden AF, Wilkinson B, Cortés J, Dunster NJ, Staunton J, Leadlay PF. Engineering broader specificity into an antibiotic-producing polyketide synthase. Science (New York, N.Y.). 279: 199-202. PMID 9422686 DOI: 10.1126/Science.279.5348.199 |
0.58 |
|
| 1998 |
Wilkinson AL, Hanefeld U, Wilkinson B, Leadlay PF, Staunton J. Enantiospecific synthesis of tetrasubstituted δ-lactones Tetrahedron Letters. 39: 9827-9830. DOI: 10.1016/S0040-4039(98)02243-6 |
0.511 |
|
| 1998 |
Weissman KJ, Smith CJ, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay PF. The thioesterase of the erythromycin-producing polyketide synthase: Influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates Angewandte Chemie - International Edition. 37: 1437-1440. DOI: 10.1002/(SICI)1521-3773(19980605)37:10<1437::AID-ANIE1437>3.0.CO;2-7 |
0.487 |
|
| 1998 |
Weissman K, Smith C, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay P. Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe Angewandte Chemie. 110: 1503-1506. DOI: 10.1002/(Sici)1521-3757(19980518)110:10<1503::Aid-Ange1503>3.0.Co;2-4 |
0.522 |
|
| 1997 |
Leadlay PF. Combinatorial approaches to polyketide biosynthesis Current Opinion in Chemical Biology. 1: 162-168. PMID 9734993 DOI: 10.1016/S1367-5931(97)80005-1 |
0.433 |
|
| 1997 |
Gaisser S, Böhm GA, Cortés J, Leadlay PF. Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic: Gene cluster in Saccharopolyspora erythraea Molecular and General Genetics. 256: 239-251. PMID 9393448 DOI: 10.1007/S004380050566 |
0.346 |
|
| 1997 |
Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF. The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. Biochemistry. 36: 13849-55. PMID 9374862 DOI: 10.1021/Bi971566B |
0.573 |
|
| 1997 |
König A, Schwecke T, Molnar I, Böhm GA, Lowden PA, Staunton J, Leadlay PF. The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. European Journal of Biochemistry / Febs. 247: 526-34. PMID 9266694 DOI: 10.1111/J.1432-1033.1997.00526.X |
0.593 |
|
| 1997 |
Galloway IS, Rowe CJ, Cortes J, Staunton J, Leadlay PF. A system for the enhanced expression of genes in saccharopolyspora erythraea and its use in the production of novel polyketides Faseb Journal. 11: A1144. |
0.457 |
|
| 1996 |
Oliynyk M, Brown MJ, Cortés J, Staunton J, Leadlay PF. A hybrid modular polyketide synthase obtained by domain swapping. Chemistry & Biology. 3: 833-9. PMID 8939702 DOI: 10.1016/S1074-5521(96)90069-1 |
0.574 |
|
| 1996 |
Thomä NH, Leadlay PF. Homology modeling of human methylmalonyl-CoA mutase: A structural basis for point mutations causing methylmalonic aciduria Protein Science. 5: 1922-1927. PMID 8880917 DOI: 10.1002/Pro.5560050919 |
0.65 |
|
| 1996 |
Mancia F, Keep NH, Nakagawa A, Leadlay PF, McSweeney S, Rasmussen B, Bösecke P, Diat O, Evans PR. How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution. Structure (London, England : 1993). 4: 339-50. PMID 8805541 DOI: 10.1016/S0969-2126(96)00037-8 |
0.372 |
|
| 1996 |
Meier TW, Thomä NH, Leadlay PF. Tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry. 35: 11791-6. PMID 8794760 DOI: 10.1021/Bi961250O |
0.659 |
|
| 1996 |
Aparicio JF, Molnár I, Schwecke T, König A, Haydock SF, Khaw LE, Staunton J, Leadlay PF. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene. 169: 9-16. PMID 8635756 DOI: 10.1016/0378-1119(95)00800-4 |
0.564 |
|
| 1996 |
Molnár I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, König A, Staunton J, Leadlay PF. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene. 169: 1-7. PMID 8635730 DOI: 10.1016/0378-1119(95)00799-7 |
0.554 |
|
| 1996 |
Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF. Evidence for a double-helical structure for modular polyketide synthases. Nature Structural Biology. 3: 188-92. PMID 8564546 DOI: 10.1038/Nsb0296-188 |
0.563 |
|
| 1996 |
Less SL, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 7. Preparation of structural analogues of the tetraketide biosynthetic precursor to tetronasin Tetrahedron Letters. 37: 3519-3520. DOI: 10.1016/0040-4039(96)00601-6 |
0.513 |
|
| 1996 |
Less SL, Handa S, Millburn K, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin Tetrahedron Letters. 37: 3515-3518. DOI: 10.1016/0040-4039(96)00600-4 |
0.517 |
|
| 1996 |
Less SL, Handa S, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 5. Novel fluorinated and non-fluorinated analogues of tetronasin via intact incorporation of di-, tri- and tetraketide analogue precursors Tetrahedron Letters. 37: 3511-3514. DOI: 10.1016/0040-4039(96)00599-0 |
0.499 |
|
| 1996 |
Lowden PAS, Böhm GA, Staunton J, Leadlay PF. The nature of the starter unit for the rapamycin polyketide synthase Angewandte Chemie (International Edition in English). 35: 2249-2251. DOI: 10.1002/Anie.199622491 |
0.5 |
|
| 1996 |
Lowden PAS, Böhm GA, Staunton J, Leadlay PF. Die Startereinheit der Rapamycin-Polyketid-Synthase Angewandte Chemie. 108: 2395-2397. DOI: 10.1002/Ange.19961081927 |
0.506 |
|
| 1995 |
Wiesmann KE, Cortés J, Brown MJ, Cutter AL, Staunton J, Leadlay PF. Polyketide synthesis in vitro on a modular polyketide synthase. Chemistry & Biology. 2: 583-9. PMID 9383462 DOI: 10.1016/1074-5521(95)90122-1 |
0.61 |
|
| 1995 |
Cortes J, Wiesmann KE, Roberts GA, Brown MJ, Staunton J, Leadlay PF. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science (New York, N.Y.). 268: 1487-9. PMID 7770773 DOI: 10.1126/Science.7770773 |
0.559 |
|
| 1995 |
Haydock SF, Aparicio JF, Molnár I, Schwecke T, Khaw LE, König A, Marsden AF, Galloway IS, Staunton J, Leadlay PF. Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. Febs Letters. 374: 246-8. PMID 7589545 DOI: 10.1016/0014-5793(95)01119-Y |
0.571 |
|
| 1995 |
Aggarwal R, Caffrey P, Leadlay PF, Smith CJ, Staunton J. The thioesterase of the erythromycin-producing polyketide synthase: Mechanistic studies in vitro to investigate its mode of action and substrate specificity Journal of the Chemical Society, Chemical Communications. 1519-1520. DOI: 10.1039/C39950001519 |
0.533 |
|
| 1995 |
Brown MJB, Cortes J, Cutter AL, Leadlay PF, Staunton J. A mutant generated by expression of an engineered DEBS 1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid Journal of the Chemical Society, Chemical Communications. 1517-1518. DOI: 10.1039/C39950001517 |
0.568 |
|
| 1994 |
Marsden AFA, Caffrey P, Aparicio JF, Loughran MS, Staunton J, Leadlay PF. Stereospecific acyl transfers on the erythromycin-producing polyketide synthase Science. 263: 378-380. PMID 8278811 DOI: 10.1126/Science.8278811 |
0.583 |
|
| 1994 |
Linton KJ, Cooper HN, Hunter IS, Leadlay PF. An ABC-transporter from streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin Molecular Microbiology. 11: 777-785. PMID 8196549 DOI: 10.1111/J.1365-2958.1994.Tb00355.X |
0.302 |
|
| 1994 |
Dutton CJ, Hooper AM, Leadlay PF, Staunton J. Avermectin biosynthesis. Intact incorporation of a diketide chain-assembly intermediate into the polyketide macrocyclic ring Tetrahedron Letters. 35: 327-330. DOI: 10.1016/S0040-4039(00)76544-0 |
0.53 |
|
| 1994 |
Hailes HC, Handa S, Leadlay PF, Lennon IC, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin Tetrahedron Letters. 35: 315-318. DOI: 10.1016/S0040-4039(00)76541-5 |
0.427 |
|
| 1994 |
Hailes HC, Handa S, Leadlay PF, Lennon IC, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase Tetrahedron Letters. 35: 311-314. DOI: 10.1016/S0040-4039(00)76540-3 |
0.502 |
|
| 1994 |
Hailes HC, Jackson CM, Leadlay PF, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase Tetrahedron Letters. 35: 307-310. DOI: 10.1016/S0040-4039(00)76539-7 |
0.505 |
|
| 1993 |
Roberts GA, Staunton J, Leadlay PF. Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. European Journal of Biochemistry / Febs. 214: 305-11. PMID 8508800 DOI: 10.1111/J.1432-1033.1993.Tb17925.X |
0.596 |
|
| 1993 |
Roberts GA, Staunton J, Leadlay PF. 6-Deoxyerythronolide B synthase 3 from Saccharopolyspora erythraea: over-expression in Escherichia coli, purification and characterisation. Biochemical Society Transactions. 21: 32S. PMID 8449313 DOI: 10.1042/Bst021032S |
0.492 |
|
| 1993 |
Cooper HN, Cortes J, Bevitt DJ, Leadlay PF, Staunton J. Analysis of a gene cluster from S. longisporoflavus potentially involved in tetronasin biosynthesis Biochemical Society Transactions. 21: 31S. PMID 8449312 DOI: 10.1042/Bst021031S |
0.491 |
|
| 1993 |
Bevitt DJ, Staunton J, Leadlay PF. Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase Biochemical Society Transactions. 21: 30S. PMID 8449310 DOI: 10.1042/Bst021030S |
0.517 |
|
| 1993 |
Leadlay PF, Staunton J, Aparicio JF, Bevitt DJ, Caffrey P, Cortes J, Marsden A, Roberts GA. The erythromycin-producing polyketide synthase. Biochemical Society Transactions. 21: 218-22. PMID 8449298 DOI: 10.1042/Bst0210218 |
0.552 |
|
| 1993 |
Morris SA, Revill WP, Staunton J, Leadlay PF. Purification and separation of holo- and apo-forms of Saccharopolyspora erythraea acyl-carrier protein released from recombinant Escherichia coli by freezing and thawing. The Biochemical Journal. 294: 521-7. PMID 8373367 DOI: 10.1042/Bj2940521 |
0.508 |
|
| 1993 |
Keep NH, Smith GA, Evans MC, Diakun GP, Leadlay PF. The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase. The Biochemical Journal. 295: 387-92. PMID 7902085 DOI: 10.1042/Bj2950387 |
0.338 |
|
| 1992 |
Bevitt DJ, Cortes J, Haydock SF, Leadlay PF. 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme European Journal of Biochemistry. 204: 39-49. PMID 1740151 DOI: 10.1111/J.1432-1033.1992.Tb16603.X |
0.416 |
|
| 1992 |
Caffrey P, Bevitt DJ, Staunton J, Leadlay PF. Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea Febs Letters. 304: 225-228. PMID 1618327 DOI: 10.1016/0014-5793(92)80624-P |
0.505 |
|
| 1992 |
Hellyer A, Leadlay PF, Slabas AR. Induction, purification and characterisation of acyl-ACP thioesterase from developing seeds of oil seed rape (Brassica napus) Plant Molecular Biology. 20: 763-780. PMID 1301073 DOI: 10.1007/Bf00027148 |
0.366 |
|
| 1991 |
Revill WP, Leadlay PF. Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis Journal of Bacteriology. 173: 4379-4385. PMID 2066335 DOI: 10.1128/Jb.173.14.4379-4385.1991 |
0.383 |
|
| 1991 |
Caffrey P, Green B, Packman LC, Rawlings BJ, Staunton J, Leadlay PF. An acyl-carrier-protein - thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli European Journal of Biochemistry. 195: 823-830. PMID 1999200 DOI: 10.1111/J.1432-1033.1991.Tb15771.X |
0.564 |
|
| 1991 |
Haydock SF, Dowson JA, Dhillon N, Roberts GA, Cortes J, Leadlay PF. Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases. Molecular & General Genetics : Mgg. 230: 120-8. PMID 1840640 DOI: 10.1007/Bf00290659 |
0.347 |
|
| 1991 |
Bridges AM, Leadlay PF, Revill WP, Staunton J. Use of electrospray mass spectrometry in enzymic studies on acyl carrier protein implicated in fatty acid biosynthesis in Saccharopolyspora erythraea Journal of the Chemical Society, Chemical Communications. 778-779. DOI: 10.1039/C39910000778 |
0.528 |
|
| 1991 |
Bridges AM, Leadlay PF, Revill WP, Staunton J. Use of electrospray mass spectrometry to assay chemical reactivity of an acyl carrier protein involved in fatty acid biosynthesis in Saccharopolyspora erythraea Journal of the Chemical Society, Chemical Communications. 776-777. DOI: 10.1039/C39910000776 |
0.507 |
|
| 1990 |
Dhillon N, Leadlay PF. A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea Febs Letters. 262: 189-193. PMID 2335200 DOI: 10.1016/0014-5793(90)80186-M |
0.317 |
|
| 1990 |
Cortes J, Haydock SF, Roberts GA, Bevitt DJ, Leadlay PF. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature. 348: 176-8. PMID 2234082 DOI: 10.1038/348176A0 |
0.398 |
|
| 1990 |
Williams KP, Leadlay PF, Lowe PN. Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues. Comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex Biochemical Journal. 268: 69-75. PMID 2188649 DOI: 10.1042/Bj2680069 |
0.373 |
|
| 1990 |
McKie N, Keep NH, Patchett ML, Leadlay PF. Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Active holoenzyme produced from Escherichia coli Biochemical Journal. 269: 293-298. PMID 1974759 DOI: 10.1042/Bj2690293 |
0.385 |
|
| 1989 |
Swan DG, Cortes J, Hale RS, Leadlay PF. Cloning, characterization, and heterologous expression of the Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-hand calcium-binding protein Journal of Bacteriology. 171: 5614-5619. PMID 2676983 DOI: 10.1128/Jb.171.10.5614-5619.1989 |
0.318 |
|
| 1989 |
Dhillon N, Hale RS, Cortes J, Leadlay PF. Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis Molecular Microbiology. 3: 1405-1414. PMID 2575703 DOI: 10.1111/J.1365-2958.1989.Tb00123.X |
0.372 |
|
| 1989 |
Marsh EN, Harding SE, Leadlay PF. Subunit interactions in Propionibacterium shermanii methylmalonyl-CoA mutase studied by analytical ultracentrifugation Biochemical Journal. 260: 353-358. PMID 2569862 DOI: 10.1042/Bj2600353 |
0.307 |
|
| 1989 |
Marsh EN, McKie N, Davis NK, Leadlay PF. Cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Biochemical Journal. 260: 345-352. PMID 2569861 DOI: 10.1042/Bj2600345 |
0.368 |
|
| 1989 |
Marsh EN, Leadlay PF. Methylmalonyl-CoA mutase from Propionibacterium shermanii. Evidence for the presence of two masked cysteine residues Biochemical Journal. 260: 339-343. PMID 2569860 DOI: 10.1042/Bj2600339 |
0.352 |
|
| 1987 |
Williams K, Lowe PN, Leadlay PF. Purification and characterization of pyruvate: ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis Biochemical Journal. 246: 529-536. PMID 3500709 DOI: 10.1042/Bj2460529 |
0.337 |
|
| 1987 |
Hale RS, Jordan KN, Leadlay PF. A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus Febs Letters. 224: 133-136. PMID 3315744 DOI: 10.1016/0014-5793(87)80436-2 |
0.33 |
|
| 1986 |
Hoving H, Crysell B, Leadlay PF. Fluorine NMR studies on stereochemical aspects of reactions catalyzed by transcarboxylase, pyruvate kinase, and enzyme I. Biochemistry. 24: 6163-9. PMID 3910092 DOI: 10.1021/Bi00343A020 |
0.344 |
|
| 1986 |
Francalanci F, Davis NK, Fuller JQ, Murfitt D, Leadlay PF. The subunit structure of methylmalonyl-CoA mutase from Propionibacterium shermanii Biochemical Journal. 236: 489-494. PMID 2875711 DOI: 10.1042/Bj2360489 |
0.343 |
|
| 1984 |
LEADLAY PF. Contemporary Enzyme Kinetics and Mechanism Biochemical Society Transactions. 12: 722-722. DOI: 10.1042/Bst0120722A |
0.307 |
|
| 1984 |
ROBERTS G, LEADLAY PF. Use of [3H]tetrahydrocerulenin to assay condensing enzyme activity in Streptomyces erythreus Biochemical Society Transactions. 12: 642-643. DOI: 10.1042/Bst0120642 |
0.305 |
|
| 1983 |
Fuller JQ, Leadlay PF. Proton transfer in methylmalonyl-CoA epimerase from Propionibacterium shermanii. The reaction of (2R)-methylmalonyl-CoA in tritiated water. The Biochemical Journal. 213: 643-50. PMID 6311170 DOI: 10.1042/Bj2130643 |
0.351 |
|
| 1983 |
Leadlay PF, Fuller JQ. Proton transfer in methylmalonyl-CoA epimerase from Propionibacterium shermanii. Studies with specifically tritiated (2R)-methylmalonyl-CoA as substrate. The Biochemical Journal. 213: 635-42. PMID 6311169 DOI: 10.1042/Bj2130635 |
0.381 |
|
| 1983 |
Roberts G, Leadlay PF. [3
H]Tetrahydrocerulenin, a specific reagent for radio-labelling fatty acid synthases and related enzymes Febs Letters. 159: 13-16. DOI: 10.1016/0014-5793(83)80407-4 |
0.327 |
|
| 1982 |
Leadlay PF. Purification and characterization of methylmalonyl-CoA epimerase from Propionibacterium shermanii. The Biochemical Journal. 197: 413-9. PMID 7325964 DOI: 10.1042/Bj1970413 |
0.36 |
|
| 1981 |
Lambiris SK, Leadlay PF. Modification of enoyl-CoA hydratase using diethyl pyrocarbonate. Biochimica Et Biophysica Acta. 660: 271-7. PMID 7284404 DOI: 10.1016/0005-2744(81)90170-4 |
0.396 |
|
| 1977 |
Leadlay PF, Breathnach R, Gatehouse JA, Johnson PE, Knowles JR. Phosphoglycerate mutase from wheat germ: studies with isotopically labeled 3-phospho-D-glycerates showing that the catalyzed reaction is intramolecular. Appendix: phosphoglycerate mutase from wheat germ: isolation, crystallization, and properties. Biochemistry. 16: 3045-53. PMID 19039 DOI: 10.1021/Bi00633A001 |
0.517 |
|
| 1976 |
Leadlay PF, Albery WJ, Knowles JR. Energetics of triosephosphate isomerase: deuterium isotope effects in the enzyme-catalyzed reaction. Biochemistry. 15: 5617-20. PMID 999836 DOI: 10.1021/Bi00670A029 |
0.537 |
|
| 1972 |
Knowles JR, Leadlay PF, Maister SG. Triosephosphate isomerase: isotope studies on the mechanistic pathway. Cold Spring Harbor Symposia On Quantitative Biology. 36: 157-64. PMID 4508134 DOI: 10.1101/Sqb.1972.036.01.022 |
0.492 |
|
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