☰

David S. Lawrence - Publications

Affiliations: 
Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Chemical Biology
Website:
http://www.chem.unc.edu/people/faculty/lawrence/index.html
Tree Info Similar researchers PubMed Report error

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kinney WD, Haar L, Lawrence DS. Lights, Camera, PAKtion: Design and Engineering of a Subcellular Targeting Optogenetic PAK1 Kinase and Sensor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35553711 DOI: 10.1096/fasebj.2022.36.S1.R3679  0.321
2021 Zywot EM, Orlova N, Ding S, Rampersad RR, Rabjohns EM, Wickenheisser VA, Wang Q, Welfare JG, Haar L, Eudy AM, Tarrant TK, Lawrence DS. Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation. Advanced Therapeutics. 5. PMID 35528736 DOI: 10.1002/adtp.202100159  0.448
2021 Anttila MM, Vickerman BM, Wang Q, Lawrence DS, Allbritton NL. Photoactivatable Reporter to Perform Multiplexed and Temporally Controlled Measurements of Kinase and Protease Activity in Single Cells. Analytical Chemistry. PMID 34865468 DOI: 10.1021/acs.analchem.1c04225  0.501
2021 Vickerman BM, O'Banion CP, Tan X, Lawrence DS. Light-Controlled Release of Therapeutic Proteins from Red Blood Cells. Acs Central Science. 7: 93-103. PMID 33532572 DOI: 10.1021/acscentsci.0c01151  0.793
2019 Parag-Sharma K, O'Banion CP, Henry EC, Musicant AM, Cleveland JL, Lawrence DS, Amelio AL. Engineered BRET-Based Biologic Light Sources Enable Spatio-Temporal Control Over Diverse Optogenetic Systems. Acs Synthetic Biology. PMID 31834783 DOI: 10.1021/Acssynbio.9B00277  0.788
2019 Marvin CM, Ding S, White RE, Orlova N, Wang Q, Zywot EM, Vickerman BM, Harr L, Tarrant TK, Dayton PA, Lawrence DS. On Command Drug Delivery via Cell-Conveyed Phototherapeutics. Small (Weinheim An Der Bergstrasse, Germany). e1901442. PMID 31353802 DOI: 10.1002/Smll.201901442  0.495
2019 O'Banion CP, Vickerman BM, Haar L, Lawrence DS. Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases. Cell Chemical Biology. PMID 31353320 DOI: 10.1016/J.Chembiol.2019.07.004  0.79
2019 Haar LL, Lawrence DS, Hughes RM. Optogenetic perturbation of the biochemical pathways that control cell behavior. Methods in Enzymology. 622: 309-328. PMID 31155059 DOI: 10.1016/Bs.Mie.2019.02.020  0.59
2019 Proctor A, Wang Q, Lawrence DS, Allbritton NL. Selection and optimization of enzyme reporters for chemical cytometry. Methods in Enzymology. 622: 221-248. PMID 31155054 DOI: 10.1016/Bs.Mie.2019.02.023  0.518
2019 O'Banion CP, Goswami A, Lawrence DS. Design, construction, and validation of optogenetic proteins. Methods in Enzymology. 621: 171-190. PMID 31128778 DOI: 10.1016/Bs.Mie.2019.02.019  0.796
2018 Cann ML, Herring LE, Haar L, Gilbert TSK, Goldfarb D, Richards KL, Graves LM, Lawrence DS. Dasatinib is preferentially active in the activated B-cell subtype of diffuse large B-cell lymphoma. Journal of Proteome Research. PMID 30540191 DOI: 10.1021/Acs.Jproteome.8B00841  0.302
2018 Lawrence D, O'banion CP. Optogenetics: A Primer for Chemists. Chembiochem : a European Journal of Chemical Biology. PMID 29671930 DOI: 10.1002/Cbic.201800013  0.769
2018 Ding S, O'Banion CP, Welfare JG, Lawrence DS. Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution. Cell Chemical Biology. PMID 29628434 DOI: 10.1016/J.Chembiol.2018.03.003  0.765
2018 Vickerman BM, Anttila MM, Peterson BV, Allbritton NL, Lawrence DS. Design and Application of Sensors for Chemical Cytometry. Acs Chemical Biology. PMID 29376326 DOI: 10.1021/Acschembio.7B01009  0.327
2018 Tarrant TK, Marvin C, Wang Q, Serafin S, Lawrence D. Light-Mediated Delivery of Therapeutics Journal of Allergy and Clinical Immunology. 141: AB197. DOI: 10.1016/J.Jaci.2017.12.624  0.498
2017 O'Banion CP, Priestman MA, Hughes RM, Herring LE, Capuzzi SJ, Lawrence DS. Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. Cell Chemical Biology. PMID 29104065 DOI: 10.1016/J.Chembiol.2017.09.011  0.806
2016 Hughes RM, Marvin CM, Rodgers ZL, Ding S, Oien NP, Smith WJ, Lawrence DS. Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents. Angewandte Chemie (International Ed. in English). PMID 27874260 DOI: 10.1002/Anie.201609731  0.754
2016 Proctor A, Zigoneanu IG, Wang Q, Sims CE, Lawrence DS, Allbritton NL. Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells. The Analyst. PMID 27704073 DOI: 10.1039/C6An01378C  0.544
2016 Mainz ER, Wang Q, Lawrence DS, Allbritton NL. An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells. Angewandte Chemie (International Ed. in English). PMID 27647713 DOI: 10.1002/Anie.201606914  0.563
2016 Rodgers ZL, Shell TA, Brugh AM, Nowotarski HL, Forbes MD, Lawrence DS. Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins. Inorganic Chemistry. PMID 26848595 DOI: 10.1021/Acs.Inorgchem.5B02036  0.75
2015 O'Banion CP, Nguyen LT, Wang Q, Priestman MA, Holly SP, Parise LV, Lawrence DS. The Plasma Membrane as a Reservoir, Protective Shield, and Light-Triggered Launch Pad for Peptide Therapeutics. Angewandte Chemie (International Ed. in English). PMID 26636264 DOI: 10.1002/Anie.201508767  0.777
2015 Turner AH, Lebhar MS, Proctor A, Wang Q, Lawrence DS, Allbritton NL. RATIONAL DESIGN OF A DEPHOSPHORYLATION-RESISTANT REPORTER ENABLES SINGLE-CELL MEASUREMENT OF TYROSINE KINASE ACTIVITY. Acs Chemical Biology. PMID 26587880 DOI: 10.1021/Acschembio.5B00667  0.541
2015 Shell TA, Lawrence DS. Vitamin B12: A Tunable, Long Wavelength, Light-Responsive Platform for Launching Therapeutic Agents. Accounts of Chemical Research. PMID 26479305 DOI: 10.1021/Acs.Accounts.5B00331  0.787
2015 Hughes RM, Freeman DJ, Lamb KN, Pollet RM, Smith WJ, Lawrence DS. Optogenetic Apoptosis: Light-Triggered Cell Death. Angewandte Chemie (International Ed. in English). 54: 12064-8. PMID 26418181 DOI: 10.1002/Anie.201506346  0.492
2015 Rodgers ZL, Hughes RM, Doherty LM, Shell JR, Molesky BP, Brugh AM, Forbes MD, Moran AM, Lawrence DS. B(12)-mediated, long wavelength photopolymerization of hydrogels. Journal of the American Chemical Society. 137: 3372-8. PMID 25697508 DOI: 10.1021/Jacs.5B00182  0.765
2015 Priestman MA, Wang Q, Jernigan FE, Chowdhury R, Schmidt M, Lawrence DS. Multicolor monitoring of the proteasome's catalytic signature. Acs Chemical Biology. 10: 433-40. PMID 25347733 DOI: 10.1021/Cb5007322  0.79
2014 Hughes RM, Lawrence DS. Optogenetic engineering: light-directed cell motility. Angewandte Chemie (International Ed. in English). 53: 10904-7. PMID 25156888 DOI: 10.1002/Anie.201404198  0.542
2014 Smith WJ, Oien NP, Hughes RM, Marvin CM, Rodgers ZL, Lee J, Lawrence DS. Cell-mediated assembly of phototherapeutics. Angewandte Chemie (International Ed. in English). 53: 10945-8. PMID 25154925 DOI: 10.1002/Anie.201406216  0.768
2014 Proctor A, Herrera-Loeza SG, Wang Q, Lawrence DS, Yeh JJ, Allbritton NL. Measurement of protein kinase B activity in single primary human pancreatic cancer cells. Analytical Chemistry. 86: 4573-80. PMID 24716819 DOI: 10.1021/Ac500616Q  0.493
2014 Oien NP, Nguyen LT, Jernigan FE, Priestman MA, Lawrence DS. Long-wavelength fluorescent reporters for monitoring protein kinase activity. Angewandte Chemie (International Ed. in English). 53: 3975-8. PMID 24604833 DOI: 10.1002/Anie.201309691  0.78
2014 Shell TA, Shell JR, Rodgers ZL, Lawrence DS. Tunable visible and near-IR photoactivation of light-responsive compounds by using fluorophores as light-capturing antennas. Angewandte Chemie (International Ed. in English). 53: 875-8. PMID 24285381 DOI: 10.1002/Anie.201308816  0.758
2013 Jernigan FE, Lawrence DS. A broad spectrum dark quencher: construction of multiple colour protease and photolytic sensors. Chemical Communications (Cambridge, England). 49: 6728-30. PMID 23778327 DOI: 10.1039/C3Cc42628A  0.74
2013 Phillips RM, Bair E, Lawrence DS, Sims CE, Allbritton NL. Measurement of protein tyrosine phosphatase activity in single cells by capillary electrophoresis. Analytical Chemistry. 85: 6136-42. PMID 23682679 DOI: 10.1021/Ac401106E  0.306
2013 Shell JR, Lawrence DS. Probes of the mitochondrial cAMP-dependent protein kinase. Biochimica Et Biophysica Acta. 1834: 1359-63. PMID 23410952 DOI: 10.1016/J.Bbapap.2013.02.002  0.79
2013 Wang Q, Priestman MA, Lawrence DS. Monitoring of protein arginine deiminase activity by using fluorescence quenching: multicolor visualization of citrullination. Angewandte Chemie (International Ed. in English). 52: 2323-5. PMID 23339123 DOI: 10.1002/Anie.201208464  0.543
2013 Phillips RM, Lawrence DS, Sims CE, Allbritton NL. Abstract 4128: A novel approach to the measurement of tyrosine phosphorylation dynamics in intact single cells using capillary electrophoresis. Cancer Research. 73: 4128-4128. DOI: 10.1158/1538-7445.Am2013-4128  0.362
2012 Xu W, Allbritton N, Lawrence DS. SRC kinase regulation in progressively invasive cancer. Plos One. 7: e48867. PMID 23145001 DOI: 10.1371/Journal.Pone.0048867  0.347
2012 Zhang S, Chen L, Lawrence DS, Zhang ZY. A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 928: 53-65. PMID 22956133 DOI: 10.1007/978-1-62703-008-3_5  0.374
2012 Proctor A, Wang Q, Lawrence DS, Allbritton NL. Development of a peptidase-resistant substrate for single-cell measurement of protein kinase B activation. Analytical Chemistry. 84: 7195-202. PMID 22881604 DOI: 10.1021/Ac301489D  0.53
2012 Priestman MA, Shell TA, Sun L, Lee HM, Lawrence DS. Merging of confocal and caging technologies: selective three-color communication with profluorescent reporters. Angewandte Chemie (International Ed. in English). 51: 7684-7. PMID 22740297 DOI: 10.1002/Anie.201202820  0.772
2012 Shell JR, Lawrence DS. Proteolytic regulation of the mitochondrial cAMP-dependent protein kinase. Biochemistry. 51: 2258-64. PMID 22385295 DOI: 10.1021/Bi201573K  0.766
2012 Proctor A, Wang Q, Lawrence DS, Allbritton NL. Metabolism of peptide reporters in cell lysates and single cells. The Analyst. 137: 3028-38. PMID 22314840 DOI: 10.1039/C2An16162A  0.511
2012 Phillips RM, Lawrence DS, Allbritton NL. Analysis of EGFR Signaling in Single Cells using Capillary Electrophoresis Biophysical Journal. 102: 666a-667a. DOI: 10.1016/J.Bpj.2011.11.3629  0.387
2012 Proctor A, Wang Q, Lawrence DS, Allbritton NL. Construction of Peptidase-Resistant Substrates for Kinases Biophysical Journal. 102: 273a. DOI: 10.1016/J.Bpj.2011.11.1503  0.529
2011 Lee HM, Xu W, Lawrence DS. Construction of a photoactivatable profluorescent enzyme via propinquity labeling. Journal of the American Chemical Society. 133: 2331-3. PMID 21302921 DOI: 10.1021/Ja108950Q  0.624
2011 Shell TA, Lawrence DS. A new trick (hydroxyl radical generation) for an old vitamin (B12). Journal of the American Chemical Society. 133: 2148-50. PMID 21275391 DOI: 10.1021/Ja111585C  0.754
2011 Priestman MA, Sun L, Lawrence DS. Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways. Acs Chemical Biology. 6: 377-84. PMID 21218856 DOI: 10.1021/Cb100398E  0.426
2010 Wang Q, Zimmerman EI, Toutchkine A, Martin TD, Graves LM, Lawrence DS. Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia. Acs Chemical Biology. 5: 887-95. PMID 20583816 DOI: 10.1021/Cb100099H  0.537
2010 Agnes RS, Jernigan F, Shell JR, Sharma V, Lawrence DS. Suborganelle sensing of mitochondrial cAMP-dependent protein kinase activity. Journal of the American Chemical Society. 132: 6075-80. PMID 20380406 DOI: 10.1021/Ja909652Q  0.789
2010 Wakata A, Lee HM, Rommel P, Toutchkine A, Schmidt M, Lawrence DS. Simultaneous fluorescent monitoring of proteasomal subunit catalysis. Journal of the American Chemical Society. 132: 1578-82. PMID 20078037 DOI: 10.1021/Ja907226N  0.607
2010 Lee HM, Priestman MA, Lawrence DS. Light-mediated spatial control via photolabile fluorescently quenched peptide cassettes. Journal of the American Chemical Society. 132: 1446-7. PMID 20073458 DOI: 10.1021/Ja907427P  0.606
2010 Priestman MA, Lawrence DS. Light-mediated remote control of signaling pathways. Biochimica Et Biophysica Acta. 1804: 547-58. PMID 19765679 DOI: 10.1016/J.Bbapap.2009.09.005  0.426
2009 Sharma V, Lawrence DS. Uber-responsive peptide-based sensors of signaling proteins. Angewandte Chemie (International Ed. in English). 48: 7290-2. PMID 19739174 DOI: 10.1002/Anie.200903717  0.355
2009 Zhang S, Chen L, Luo Y, Gunawan A, Lawrence DS, Zhang ZY. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. Journal of the American Chemical Society. 131: 13072-9. PMID 19737019 DOI: 10.1021/Ja903733Z  0.354
2009 Lee HM, Larson DR, Lawrence DS. Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds. Acs Chemical Biology. 4: 409-27. PMID 19298086 DOI: 10.1021/Cb900036S  0.586
2008 Li H, Hah JM, Lawrence DS. Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents. Journal of the American Chemical Society. 130: 10474-5. PMID 18642802 DOI: 10.1021/Ja803395D  0.661
2008 Lee JH, Kumar S, Lawrence DS. Stepwise combinatorial evolution of Akt bisubstrate inhibitors. Chembiochem : a European Journal of Chemical Biology. 9: 507-9. PMID 18224646 DOI: 10.1002/Cbic.200700583  0.62
2008 Garrett SC, Hodgson L, Rybin A, Toutchkine A, Hahn KM, Lawrence DS, Bresnick AR. A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry. 47: 986-96. PMID 18154362 DOI: 10.1021/Bi7021624  0.36
2008 Wakata A, Cahill SM, Blumenstein M, Gunby RH, Jockusch S, Marti AA, Cimbro B, Gambacorti-Passerini C, Donella-Deana A, Pinna LA, Turro NJ, Lawrence DS. A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target. Organic Letters. 10: 301-4. PMID 18085786 DOI: 10.1021/Ol702675B  0.367
2008 Sharma V, Wang Q, Lawrence DS. Peptide-based fluorescent sensors of protein kinase activity: design and applications. Biochimica Et Biophysica Acta. 1784: 94-9. PMID 17881302 DOI: 10.1016/J.Bbapap.2007.07.016  0.559
2007 Dai Z, Dulyaninova NG, Kumar S, Bresnick AR, Lawrence DS. Visual snapshots of intracellular kinase activity at the onset of mitosis. Chemistry & Biology. 14: 1254-60. PMID 18022564 DOI: 10.1016/J.Chembiol.2007.10.007  0.678
2007 Zhang S, Chen L, Kumar S, Wu L, Lawrence DS, Zhang ZY. An affinity-based fluorescence polarization assay for protein tyrosine phosphatases. Methods (San Diego, Calif.). 42: 261-7. PMID 17532513 DOI: 10.1016/J.Ymeth.2007.02.008  0.57
2007 Nandy SK, Agnes RS, Lawrence DS. Photochemically-activated probes of protein-protein interactions. Organic Letters. 9: 2249-52. PMID 17506572 DOI: 10.1021/Ol070238T  0.411
2007 Sharma V, Agnes RS, Lawrence DS. Deep quench: an expanded dynamic range for protein kinase sensors. Journal of the American Chemical Society. 129: 2742-3. PMID 17305340 DOI: 10.1021/Ja068280R  0.401
2007 Lawrence DS, Wang Q. Seeing is believing: peptide-based fluorescent sensors of protein tyrosine kinase activity. Chembiochem : a European Journal of Chemical Biology. 8: 373-8. PMID 17243187 DOI: 10.1002/Cbic.200600473  0.567
2006 Wang Q, Dai Z, Cahill SM, Blumenstein M, Lawrence DS. Light-regulated sampling of protein tyrosine kinase activity. Journal of the American Chemical Society. 128: 14016-7. PMID 17061870 DOI: 10.1021/Ja065852Z  0.669
2006 Hah JM, Sharma V, Li H, Lawrence DS. Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy. Journal of the American Chemical Society. 128: 5996-7. PMID 16669643 DOI: 10.1021/Ja060136I  0.633
2006 Wang Q, Cahill SM, Blumenstein M, Lawrence DS. Self-reporting fluorescent substrates of protein tyrosine kinases. Journal of the American Chemical Society. 128: 1808-9. PMID 16464077 DOI: 10.1021/Ja0577692  0.559
2006 Lee H, Xie L, Luo Y, Lee SY, Lawrence DS, Wang XB, Sotgia F, Lisanti MP, Zhang ZY. Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. Biochemistry. 45: 234-40. PMID 16388599 DOI: 10.1021/Bi051560J  0.393
2005 Varfolomeev E, Maecker H, Sharp D, Lawrence D, Renz M, Vucic D, Ashkenazi A. Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. The Journal of Biological Chemistry. 280: 40599-608. PMID 16227629 DOI: 10.1074/Jbc.M509560200  0.324
2005 Lawrence DS. The preparation and in vivo applications of caged peptides and proteins. Current Opinion in Chemical Biology. 9: 570-5. PMID 16182597 DOI: 10.1016/J.Cbpa.2005.09.002  0.379
2005 Lawrence DS. Signaling protein inhibitors via the combinatorial modification of peptide scaffolds. Biochimica Et Biophysica Acta. 1754: 50-7. PMID 16172031 DOI: 10.1016/J.Bbapap.2005.07.038  0.381
2005 Li H, Lawrence DS. Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy. Chemistry & Biology. 12: 905-12. PMID 16125102 DOI: 10.1016/J.Chembiol.2005.06.007  0.332
2005 Wang Q, Lawrence DS. Phosphorylation-driven protein-protein interactions: a protein kinase sensing system. Journal of the American Chemical Society. 127: 7684-5. PMID 15913351 DOI: 10.1021/Ja050789J  0.566
2005 Liang F, Lee SY, Liang J, Lawrence DS, Zhang ZY. The role of protein-tyrosine phosphatase 1B in integrin signaling. The Journal of Biological Chemistry. 280: 24857-63. PMID 15866871 DOI: 10.1074/Jbc.M502780200  0.383
2005 Kumar S, Liang F, Lawrence DS, Zhang ZY. Small molecule approach to studying protein tyrosine phosphatase. Methods (San Diego, Calif.). 35: 9-21. PMID 15588981 DOI: 10.1016/J.Ymeth.2004.07.003  0.538
2004 Ghosh M, Song X, Mouneimne G, Sidani M, Lawrence DS, Condeelis JS. Cofilin promotes actin polymerization and defines the direction of cell motility. Science (New York, N.Y.). 304: 743-6. PMID 15118165 DOI: 10.1126/Science.1094561  0.572
2004 Lee JH, Nandy SK, Lawrence DS. A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold. Journal of the American Chemical Society. 126: 3394-5. PMID 15025445 DOI: 10.1021/Ja037300B  0.543
2004 Chen CA, Yeh RH, Yan X, Lawrence DS. Biosensors of protein kinase action: from in vitro assays to living cells. Biochimica Et Biophysica Acta. 1697: 39-51. PMID 15023349 DOI: 10.1016/J.Bbapap.2003.11.012  0.44
2003 Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky JM, Lawrence DS, Zhang ZY. Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry. 42: 12792-804. PMID 14596593 DOI: 10.1021/Bi035238P  0.618
2003 Veldhuyzen WF, Nguyen Q, McMaster G, Lawrence DS. A light-activated probe of intracellular protein kinase activity. Journal of the American Chemical Society. 125: 13358-9. PMID 14583022 DOI: 10.1021/Ja037801X  0.418
2003 Liang F, Huang Z, Lee SY, Liang J, Ivanov MI, Alonso A, Bliska JB, Lawrence DS, Mustelin T, Zhang ZY. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. The Journal of Biological Chemistry. 278: 41734-41. PMID 12888560 DOI: 10.1074/Jbc.M307152200  0.353
2003 Lawrence DS. Chemical probes of signal-transducing proteins. Accounts of Chemical Research. 36: 401-9. PMID 12809526 DOI: 10.1021/Ar020132S  0.417
2003 Shang L, Kwon YG, Nandy S, Lawrence DS, Edelman AM. Catalytic and regulatory domains of doublecortin kinase-1. Biochemistry. 42: 2185-94. PMID 12590608 DOI: 10.1021/Bi026913I  0.37
2003 Sun JP, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. The Journal of Biological Chemistry. 278: 12406-14. PMID 12547827 DOI: 10.1074/Jbc.M212491200  0.634
2002 Lin W, Albanese C, Pestell RG, Lawrence DS. Spatially discrete, light-driven protein expression. Chemistry & Biology. 9: 1347-53. PMID 12498888 DOI: 10.1016/S1074-5521(02)00288-0  0.465
2002 Guo XL, Shen K, Wang F, Lawrence DS, Zhang ZY. Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition. The Journal of Biological Chemistry. 277: 41014-22. PMID 12193602 DOI: 10.1074/Jbc.M207347200  0.643
2002 Yeh RH, Lee TR, Lawrence DS. From consensus sequence to high-affinity ligands: acquisition of signaling protein modulators. Pharmacology & Therapeutics. 93: 179-91. PMID 12191610 DOI: 10.1016/S0163-7258(02)00187-0  0.345
2002 Lin W, Lawrence DS. A strategy for the construction of caged diols using a photolabile protecting group. The Journal of Organic Chemistry. 67: 2723-6. PMID 11950329 DOI: 10.1021/Jo0163851  0.486
2002 Chen CA, Yeh RH, Lawrence DS. Design and synthesis of a fluorescent reporter of protein kinase activity. Journal of the American Chemical Society. 124: 3840-1. PMID 11942815 DOI: 10.1021/Ja017530V  0.395
2002 Ghosh M, Ichetovkin I, Song X, Condeelis JS, Lawrence DS. A new strategy for caging proteins regulated by kinases. Journal of the American Chemical Society. 124: 2440-1. PMID 11890784 DOI: 10.1021/Ja017592L  0.59
2002 Yeh RH, Yan X, Cammer M, Bresnick AR, Lawrence DS. Real time visualization of protein kinase activity in living cells. The Journal of Biological Chemistry. 277: 11527-32. PMID 11790790 DOI: 10.1074/Jbc.M111300200  0.426
2001 Shen K, Keng YF, Wu L, Guo XL, Lawrence DS, Zhang ZY. Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure. The Journal of Biological Chemistry. 276: 47311-9. PMID 11584002 DOI: 10.1074/Jbc.M106568200  0.653
2001 Yeh RH, Lee TR, Lawrence DS. From consensus sequence peptide to high affinity ligand, a "library scan" strategy. The Journal of Biological Chemistry. 276: 12235-40. PMID 11278862 DOI: 10.1074/Jbc.M011232200  0.308
2001 Lawrence DS. Functional proteomics: large-scale analysis of protein kinase activity. Genome Biology. 2: REVIEWS1007. PMID 11182893 DOI: 10.1186/Gb-2001-2-2-Reviews1007  0.371
2001 Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS, Hawkins RD. Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 143-9. PMID 11150330 DOI: 10.1523/Jneurosci.21-01-00143.2001  0.32
2001 Profit AA, Lee TR, Niu J, Lawrence DS. Molecular rulers: an assessment of distance and spatial relationships of Src tyrosine kinase Sh2 and active site regions. The Journal of Biological Chemistry. 276: 9446-51. PMID 11118446 DOI: 10.1074/Jbc.M009262200  0.344
2001 Zhou B, Wu L, Shen K, Zhang J, Lawrence DS, Zhang ZY. Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2. The Journal of Biological Chemistry. 276: 6506-15. PMID 11104775 DOI: 10.1074/Jbc.M009753200  0.651
2000 Zebda N, Bernard O, Bailly M, Welti S, Lawrence DS, Condeelis JS. Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension. The Journal of Cell Biology. 151: 1119-28. PMID 11086013 DOI: 10.1083/Jcb.151.5.1119  0.329
2000 Yan X, Curley K, Lawrence DS. The specificity of the protein kinase C alpha, betaII and gamma isoforms as assessed by an unnatural alcohol-appended peptide library. The Biochemical Journal. 349: 709-15. PMID 10903131 DOI: 10.1042/Bj3490709  0.356
2000 Vetter SW, Keng YF, Lawrence DS, Zhang ZY. Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning". The Journal of Biological Chemistry. 275: 2265-8. PMID 10644673 DOI: 10.1074/Jbc.275.4.2265  0.335
1999 Curley K, Lawrence DS. Caged regulators of signaling pathways. Pharmacology & Therapeutics. 82: 347-54. PMID 10454211 DOI: 10.1016/S0163-7258(98)00055-2  0.398
1999 Taing M, Keng YF, Shen K, Wu L, Lawrence DS, Zhang ZY. Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B. Biochemistry. 38: 3793-803. PMID 10090769 DOI: 10.1021/Bi9813781  0.644
1999 Curley K, Lawrence DS. Light-activated proteins. Current Opinion in Chemical Biology. 3: 84-8. PMID 10021410 DOI: 10.1016/S1367-5931(99)80015-5  0.381
1999 Profit AA, Lee TR, Lawrence DS. Bivalent inhibitors of protein tyrosine kinases Journal of the American Chemical Society. 121: 280-283. DOI: 10.1021/Ja983515N  0.398
1998 Lawrence DS, Niu J. Protein kinase inhibitors: the tyrosine-specific protein kinases. Pharmacology & Therapeutics. 77: 81-114. PMID 9578319 DOI: 10.1016/S0163-7258(97)00052-1  0.392
1998 White RR, Kwon YG, Taing M, Lawrence DS, Edelman AM. Definition of optimal substrate recognition motifs of Ca2+-calmodulin-dependent protein kinases IV and II reveals shared and distinctive features. The Journal of Biological Chemistry. 273: 3166-72. PMID 9452427 DOI: 10.1074/Jbc.273.6.3166  0.345
1998 Wood JS, Koszelak M, Liu J, Lawrence DS. A caged protein kinase inhibitor [23] Journal of the American Chemical Society. 120: 7145-7146. DOI: 10.1021/Ja980960+  0.355
1997 Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proceedings of the National Academy of Sciences of the United States of America. 94: 13420-5. PMID 9391040 DOI: 10.1073/Pnas.94.25.13420  0.302
1997 Pluskey S, Mahroof-Tahir M, Crans DC, Lawrence DS. Vanadium oxoanions and cAMP-dependent protein kinase: an anti-substrate inhibitor. The Biochemical Journal. 321: 333-9. PMID 9020863 DOI: 10.1042/Bj3210333  0.386
1997 Niu J, Lawrence DS. Nonphosphorylatable tyrosine surrogates. Implications for protein kinase inhibitor design. The Journal of Biological Chemistry. 272: 1493-9. PMID 8999819 DOI: 10.1074/Jbc.272.3.1493  0.388
1996 Chen L, Montserat J, Lawrence DS, Zhang ZY. VHR and PTP1 protein phosphatases exhibit remarkably different active site specificities toward low molecular weight nonpeptidic substrates Biochemistry. 35: 9349-9354. PMID 8755712 DOI: 10.1021/Bi960700+  0.383
1996 Wang C, Lee TR, Lawrence DS, Adams JA. Rate-determining steps for tyrosine phosphorylation by the kinase domain of v-fps. Biochemistry. 35: 1533-9. PMID 8634284 DOI: 10.1021/Bi952435I  0.374
1996 Montserat J, Chen L, Lawrence DS, Zhang ZY. Potent low molecular weight substrates for protein-tyrosine phosphatase Journal of Biological Chemistry. 271: 7868-7872. PMID 8631832 DOI: 10.1074/Jbc.271.13.7868  0.361
1996 Yan X, Corbin JD, Francis SH, Lawrence DS. Precision targeting of protein kinases: An affinity label that inactivates the cGMP- but not the cAMP-dependent protein kinase Journal of Biological Chemistry. 271: 1845-1848. PMID 8567627 DOI: 10.1074/Jbc.271.4.1845  0.388
1996 Werner DS, Lee TR, Lawrence DS. Is protein kinase substrate efficacy a reliable barometer for successful inhibitor design? Journal of Biological Chemistry. 271: 180-185. PMID 8550556 DOI: 10.1074/Jbc.271.1.180  0.343
1996 Wood JS, Yan X, Mendelow M, Corbin JD, Francis SH, Lawrence DS. Precision substrate targeting of protein kinases: The cGMP- and cAMP-dependent protein kinases Journal of Biological Chemistry. 271: 174-179. PMID 8550555 DOI: 10.1074/Jbc.271.1.174  0.372
1996 Dunn D, Chen L, Lawrence DS, Zhang ZY. The active site specificity of the Yersinia protein-tyrosine phosphatase Journal of Biological Chemistry. 271: 168-173. PMID 8550553 DOI: 10.1074/Jbc.271.1.168  0.364
1996 Yan X, Lawrence DS, Corbin JD, Francis SH. Distinguishing between A mitogenic and two closely related nonmitogenic protein kinases Journal of the American Chemical Society. 118: 11684-11685. DOI: 10.1021/Ja963129A  0.341
1996 Yan X, Lawrence DS, Corbin JD, Francis SH. Distinguishing between closely related protein kinases: A variation on the bisubstrate inhibitor theme Journal of the American Chemical Society. 118: 6321-6322. DOI: 10.1021/Ja9609213  0.347
1995 Srinivasan J, Koszelak M, Mendelow M, Kwon YG, Lawrence DS. The design of peptide-based substrates for the cdc2 protein kinase. The Biochemical Journal. 927-31. PMID 7639712 DOI: 10.1042/Bj3090927  0.382
1995 Lee TR, Till JH, Lawrence DS, Miller WT. Precision substrate targeting of protein kinases v-Abl and c-Src. The Journal of Biological Chemistry. 270: 27022-6. PMID 7592951 DOI: 10.1074/Jbc.270.45.27022  0.49
1995 Lee TR, Niu J, Lawrence DS. The extraordinary active site substrate specificity of pp60c-src: A multiple specificity protein kinase Journal of Biological Chemistry. 270: 5375-5380. PMID 7534295 DOI: 10.1074/Jbc.270.10.5375  0.403
1994 Lee TR, Niu J, Lawrence DS. Phenol kinase activity of the serine/threonine-specific cAMP-dependent protein kinase: steric and electronic effects. Biochemistry. 33: 4245-50. PMID 8155641 DOI: 10.1021/Bi00180A019  0.351
1994 Lee JC, Kwon YG, Lawrence DS, Edelman AM. A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia. Proceedings of the National Academy of Sciences of the United States of America. 91: 6413-7. PMID 8022798 DOI: 10.1073/Pnas.91.14.6413  0.319
1993 Lee TR, Mendelow M, Srinivasan J, Kwon YG, Lawrence DS. Molecular basis for the substrate specificity of a serine threonine-specific protein kinase Journal of the American Chemical Society. 115: 9888-9891. DOI: 10.1021/Ja00075A003  0.373
1993 Kwon YG, Srinivasan J, Mendelow M, Pluskey S, Lawrence DS. The cAMP-dependent protein kinase discriminates between prochiral hydroxyl groups Journal of the American Chemical Society. 115: 7527-7528. DOI: 10.1021/Ja00069A072  0.34
1992 Dick DL, Rao TVS, Sukumaran D, Lawrence DS. Molecular encapsulation: cyclodextrin-based analogs of heme-containing proteins Journal of the American Chemical Society. 114: 2664-2669. DOI: 10.1021/Ja00033A046  0.322
1991 Sukumaran DK, Prorok M, Lawrence DS. A molecular constraint that generates a cis peptide bond Journal of the American Chemical Society. 113: 706-707. DOI: 10.1021/Ja00002A067  0.696
1990 Prorok M, Lawrence DS. Multiple arginine residues contribute to the increased efficacy of peptide substrates for the cAMP-dependent protein kinase. Biochemical and Biophysical Research Communications. 165: 368-71. PMID 2590233 DOI: 10.1016/0006-291X(89)91079-6  0.378
1990 Prorok M, Lawrence DS. An affinity label of absolute peptidic origin Journal of the American Chemical Society. 112: 8626-8627. DOI: 10.1021/Ja00179A081  0.7
1989 Prorok M, Lawrence DS. Intrasubstrate steric interactions in the active site control the specificity of the cAMP-dependent protein kinase. Biochemical and Biophysical Research Communications. 158: 136-40. PMID 2912444 DOI: 10.1016/S0006-291X(89)80188-3  0.384
1989 Prorok M, Lawrence DS. Cryopreservation of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase from bovine cardiac muscle. Journal of Biochemical and Biophysical Methods. 18: 167-75. PMID 2732419 DOI: 10.1016/0165-022X(89)90001-8  0.324
1985 Kaiser ET, Lawrence DS, Rokita SE. The chemical modification of enzymatic specificity. Annual Review of Biochemistry. 54: 565-95. PMID 2992359 DOI: 10.1146/Annurev.Bi.54.070185.003025  0.526
1985 Stevens RV, Lawrence DS. Camphorae: chiral intermediates fob the total synthesis of steroids. Part 2. An enantiospecific approach toward vitamin d metabolites Tetrahedron. 41: 93-100. DOI: 10.1016/S0040-4020(01)83472-4  0.424
1985 DOUGHTY MB, LAWRENCE DS. ChemInform Abstract: ON THE INTRAMOLECULAR CYCLIZATION OF A THIAZOLIUM SALT Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198531213  0.422
1984 O'Brian CA, Lawrence DS, Kaiser ET, Weinstein IB. Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter. Biochemical and Biophysical Research Communications. 124: 296-302. PMID 6238595 DOI: 10.1016/0006-291X(84)90951-3  0.532
1984 Kaiser ET, Lawrence DS. Chemical mutation of enzyme active sites. Science (New York, N.Y.). 226: 505-11. PMID 6238407 DOI: 10.1126/Science.6238407  0.516
1983 Stevens RV, Gaeta FCA, Lawrence DS. Camphorae: Chiral intermediates for the enantiospecific total synthesis of steroids. 1 Journal of the American Chemical Society. 105: 7713-7719. DOI: 10.1002/Chin.198414324  0.484
1982 Trueblood KN, Knobler CB, Lawrence DS, Stevens RV. Structures of the 1:1 complexes of 18-crown-6 with hydrazinium perchlorate, hydroxylammonium perchlorate, and methylammonium perchlorate Journal of the American Chemical Society. 104: 1355-1362. DOI: 10.1002/Chin.198226057  0.409
Show low-probability matches.