| Year |
Citation |
Score |
| 2019 |
Katzman BM, Cox BD, Prosser AR, Alcaraz AA, Murat B, Héroux M, Tebben A, Zhang Y, Schroeder GM, Snyder JP, Wilson LJ, Liotta DC. Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor. Acs Medicinal Chemistry Letters. 10: 67-73. PMID 30655949 DOI: 10.1021/Acsmedchemlett.8B00441 |
0.669 |
|
| 2018 |
Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF. The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins. PMID 30168177 DOI: 10.1002/Prot.25595 |
0.496 |
|
| 2015 |
Cox BD, Mehta AK, DiRaddo JO, Liotta DC, Wilson LJ, Snyder JP. Structural analysis of CXCR4 - Antagonist interactions using saturation-transfer double-difference NMR. Biochemical and Biophysical Research Communications. 466: 28-32. PMID 26301631 DOI: 10.1016/J.Bbrc.2015.08.084 |
0.529 |
|
| 2015 |
Cox BD, Prosser AR, Sun Y, Li Z, Lee S, Huang MB, Bond VC, Snyder JP, Krystal M, Wilson LJ, Liotta DC. Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. Acs Medicinal Chemistry Letters. 6: 753-7. PMID 26191361 DOI: 10.1021/Acsmedchemlett.5B00036 |
0.499 |
|
| 2015 |
Shi Q, Kaiser TM, Dentmon ZW, Ceruso M, Vullo D, Supuran CT, Snyder JP. Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis. Acs Medicinal Chemistry Letters. 6: 518-22. PMID 26005525 DOI: 10.1021/Acsmedchemlett.5B00062 |
0.323 |
|
| 2015 |
Yuan H, Myers SJ, Wells G, Nicholson KL, Swanger SA, Lyuboslavsky P, Tahirovic YA, Menaldino DS, Ganesh T, Wilson LJ, Liotta DC, Snyder JP, Traynelis SF. Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects. Neuron. 85: 1305-18. PMID 25728572 DOI: 10.1016/J.Neuron.2015.02.008 |
0.457 |
|
| 2015 |
Baldwin PR, Reeves AZ, Powell KR, Napier RJ, Swimm AI, Sun A, Giesler K, Bommarius B, Shinnick TM, Snyder JP, Liotta DC, Kalman D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 92: 693-9. PMID 25618016 DOI: 10.1016/J.Ejmech.2015.01.020 |
0.471 |
|
| 2015 |
Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore TW, Parker ET, Sun A, Sarkaria JN, Snyder JP, Liotta DC, Brat DJ, El-Rayes BF, Shoji M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. Journal of Drug Targeting. 23: 257-65. PMID 25510254 DOI: 10.3109/1061186X.2014.988217 |
0.451 |
|
| 2014 |
Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore TW, Parker ET, Sun A, Liotta DC, El-Rayes BF, Brat DJ, Snyder JP, Shoji M. Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases. Journal of Drug Delivery. 2014: 865732. PMID 25574399 DOI: 10.1155/2014/865732 |
0.467 |
|
| 2014 |
Kim MS, Buisson LA, Heathcote DA, Hu H, Braddock DC, Barrett AG, Ashton-Rickardt PG, Snyder JP. Approaches to design non-covalent inhibitors for human granzyme B (hGrB). Organic & Biomolecular Chemistry. 12: 8952-65. PMID 25277547 DOI: 10.1039/C4Ob01874E |
0.349 |
|
| 2014 |
Zhou T, Ye L, Bai Y, Sun A, Cox B, Liu D, Li Y, Liotta D, Snyder JP, Fu H, Huang B. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog. Plos One. 9: e107876. PMID 25268357 DOI: 10.1371/Journal.Pone.0107876 |
0.475 |
|
| 2014 |
Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60. PMID 25205677 DOI: 10.1124/Mol.114.094516 |
0.481 |
|
| 2014 |
Grimmer C, Moore TW, Padwa A, Prussia A, Wells G, Wu S, Sun A, Snyder JP. Antiviral atropisomers: conformational energy surfaces by NMR for host-directed myxovirus blockers. Journal of Chemical Information and Modeling. 54: 2214-23. PMID 25058809 DOI: 10.1021/Ci500204J |
0.332 |
|
| 2014 |
Kingston DG, Snyder JP. The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent. Accounts of Chemical Research. 47: 2682-91. PMID 25052294 DOI: 10.1021/Ar500203H |
0.387 |
|
| 2014 |
Cox BD, Prosser AR, Katzman BM, Alcaraz AA, Liotta DC, Wilson LJ, Snyder JP. Anti-HIV small-molecule binding in the peptide subpocket of the CXCR4:CVX15 crystal structure. Chembiochem : a European Journal of Chemical Biology. 15: 1614-20. PMID 24990206 DOI: 10.1002/Cbic.201402056 |
0.666 |
|
| 2014 |
Moore TW, Zhu S, Randolph R, Shoji M, Snyder JP. Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109. Acs Medicinal Chemistry Letters. 5: 288-92. PMID 24900828 DOI: 10.1021/Ml4002453 |
0.313 |
|
| 2014 |
Hu H, Mao S, Bugrysheva JV, Pruett S, Liotta DC, Scott JR, Snyder JP. Group A streptococcus inhibitors by high-throughput virtual screening. European Journal of Medicinal Chemistry. 82: 120-6. PMID 24880231 DOI: 10.1016/J.Ejmech.2014.05.006 |
0.484 |
|
| 2013 |
Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ. Discovery of tetrahydroisoquinoline-based CXCR4 antagonists. Acs Medicinal Chemistry Letters. 4: 1025-30. PMID 24936240 DOI: 10.1021/Ml400183Q |
0.67 |
|
| 2013 |
Moore TW, Sana K, Yan D, Krumm SA, Thepchatri P, Snyder JP, Marengo J, Arrendale RF, Prussia AJ, Natchus MG, Liotta DC, Plemper RK, Sun A. Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy. Acs Medicinal Chemistry Letters. 4: 762-767. PMID 23956816 DOI: 10.1021/Ml400166B |
0.469 |
|
| 2013 |
Acker TM, Khatri A, Vance KM, Slabber C, Bacsa J, Snyder JP, Traynelis SF, Liotta DC. Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. Journal of Medicinal Chemistry. 56: 6434-56. PMID 23909910 DOI: 10.1021/Jm400652R |
0.483 |
|
| 2013 |
Brown A, Shi Q, Moore TW, Yoon Y, Prussia A, Maddox C, Liotta DC, Shim H, Snyder JP. Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. Journal of Medicinal Chemistry. 56: 3456-66. PMID 23550937 DOI: 10.1021/Jm4002692 |
0.499 |
|
| 2013 |
Mooring SR, Liu J, Liang Z, Ahn J, Hong S, Yoon Y, Snyder JP, Shim H. Benzenesulfonamides: a unique class of chemokine receptor type 4 inhibitors. Chemmedchem. 8: 622-32. PMID 23468189 DOI: 10.1002/Cmdc.201200582 |
0.357 |
|
| 2013 |
Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Asymmetric synthesis of host-directed inhibitors of myxoviruses. Beilstein Journal of Organic Chemistry. 9: 197-203. PMID 23400228 DOI: 10.3762/Bjoc.9.23 |
0.507 |
|
| 2012 |
Shi Q, Yin S, Kaluz S, Ni N, Devi NS, Mun J, Wang D, Damera K, Chen W, Burroughs S, Mooring SR, Goodman MM, Van Meir EG, Wang B, Snyder JP. Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor. Acs Medicinal Chemistry Letters. 3: 620-5. PMID 24936238 DOI: 10.1021/Ml300042K |
0.304 |
|
| 2012 |
Hu H, Snyder JP. Models for predicting IKKA and IKKB blockade. Journal of Chemical Information and Modeling. 52: 3190-9. PMID 23157456 DOI: 10.1021/Ci300287T |
0.313 |
|
| 2012 |
Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation. Chemmedchem. 7: 1909-14. PMID 22961990 DOI: 10.1002/Cmdc.201200307 |
0.343 |
|
| 2012 |
Mun J, Jabbar AA, Devi NS, Yin S, Wang Y, Tan C, Culver D, Snyder JP, Van Meir EG, Goodman MM. Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents. Journal of Medicinal Chemistry. 55: 6738-50. PMID 22746274 DOI: 10.1021/Jm300752N |
0.313 |
|
| 2012 |
Smith SM, Min J, Ganesh T, Diebold B, Kawahara T, Zhu Y, McCoy J, Sun A, Snyder JP, Fu H, Du Y, Lewis I, Lambeth JD. Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chemistry & Biology. 19: 752-63. PMID 22726689 DOI: 10.1016/J.Chembiol.2012.04.015 |
0.326 |
|
| 2012 |
Burger PB, Yuan H, Karakas E, Geballe M, Furukawa H, Liotta DC, Snyder JP, Traynelis SF. Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular Pharmacology. 82: 344-59. PMID 22596351 DOI: 10.1124/Mol.112.078568 |
0.521 |
|
| 2012 |
Liang Z, Zhan W, Zhu A, Yoon Y, Lin S, Sasaki M, Klapproth JM, Yang H, Grossniklaus HE, Xu J, Rojas M, Voll RJ, Goodman MM, Arrendale RF, Liu J, ... ... Snyder JP, et al. Development of a unique small molecule modulator of CXCR4. Plos One. 7: e34038. PMID 22485156 DOI: 10.1371/Journal.Pone.0034038 |
0.514 |
|
| 2012 |
Ndungu JM, Krumm SA, Yan D, Arrendale RF, Reddy GP, Evers T, Howard R, Natchus MG, Saindane MT, Liotta DC, Plemper RK, Snyder JP, Sun A. Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics. Journal of Medicinal Chemistry. 55: 4220-30. PMID 22480182 DOI: 10.1021/Jm201699W |
0.49 |
|
| 2012 |
Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International Immunopharmacology. 12: 368-77. PMID 22197802 DOI: 10.1016/J.Intimp.2011.12.009 |
0.467 |
|
| 2011 |
Zhan W, Jiang Y, Sharma S, Brodie PJ, Bane S, Kingston DG, Liotta DC, Snyder JP. C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14792-804. PMID 22127984 DOI: 10.1002/Chem.201102630 |
0.524 |
|
| 2011 |
Zhao J, Bane S, Snyder JP, Hu H, Mukherjee K, Slebodnick C, Kingston DG. Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation. Bioorganic & Medicinal Chemistry. 19: 7664-78. PMID 22071526 DOI: 10.1016/J.Bmc.2011.10.010 |
0.349 |
|
| 2011 |
Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Molecular Pharmacology. 80: 782-95. PMID 21807990 DOI: 10.1124/Mol.111.073239 |
0.512 |
|
| 2011 |
Krumm SA, Ndungu JM, Yoon JJ, Dochow M, Sun A, Natchus M, Snyder JP, Plemper RK. Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases. Plos One. 6: e20069. PMID 21603574 DOI: 10.1371/Journal.Pone.0020069 |
0.312 |
|
| 2011 |
Sun A, Moore TW, Gunther JR, Kim MS, Rhoden E, Du Y, Fu H, Snyder JP, Katzenellenbogen JA. Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency. Chemmedchem. 6: 654-66. PMID 21365764 DOI: 10.1002/Cmdc.201000507 |
0.367 |
|
| 2011 |
Jogalekar AS, Damodaran K, Kriel FH, Jung WH, Alcaraz AA, Zhong S, Curran DP, Snyder JP. Dictyostatin flexibility bridges conformations in solution and in the β-tubulin taxane binding site. Journal of the American Chemical Society. 133: 2427-36. PMID 21299225 DOI: 10.1021/Ja1023817 |
0.603 |
|
| 2011 |
Chapman-Rothe N, Shamsaei E, Cherblanc F, Ganesh T, Snyder JP, Fuchter MJ, Brown R. Abstract A162: Targeting chromatin: Small molecules reactivating H3K27me3 silenced genes. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A162 |
0.322 |
|
| 2010 |
Zhu A, Zhan W, Liang Z, Yoon Y, Yang H, Grossniklaus HE, Xu J, Rojas M, Lockwood M, Snyder JP, Liotta DC, Shim H. Dipyrimidine amines: A novel class of chemokine receptor type 4 antagonists with high specificity Journal of Medicinal Chemistry. 53: 8556-8568. PMID 21105715 DOI: 10.1021/Jm100786G |
0.542 |
|
| 2010 |
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, ... Snyder JP, et al. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Journal of Medicinal Chemistry. 53: 8508-22. PMID 21080703 DOI: 10.1021/Jm100732T |
0.488 |
|
| 2010 |
Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta D, Fu H. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical Pharmacology. 80: 1309-16. PMID 20615389 DOI: 10.1016/J.Bcp.2010.06.048 |
0.493 |
|
| 2010 |
Ndungu JM, Lu YJ, Zhu S, Yang C, Wang X, Chen G, Shin DM, Snyder JP, Shoji M, Sun A. Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation. Journal of Medicinal Chemistry. 53: 3127-32. PMID 20302303 DOI: 10.1021/Jm901763F |
0.305 |
|
| 2010 |
Pandey KK, Snyder JP, Liotta DC, Musaev DG. Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP). The Journal of Physical Chemistry. B. 114: 1127-35. PMID 20020721 DOI: 10.1021/Jp909945E |
0.44 |
|
| 2010 |
Prussia AJ, Yang Y, Geballe MT, Snyder JP. Cyclostreptin and microtubules: Is a low-affinity binding site required? Chembiochem. 11: 101-109. PMID 19946930 DOI: 10.1002/Cbic.200900538 |
0.313 |
|
| 2010 |
Jogalekar AS, Kriel FH, Shi Q, Cornett B, Cicero D, Snyder JP. The discodermolide hairpin structure flows from conformationally stable modular motifs Journal of Medicinal Chemistry. 53: 155-165. PMID 19894728 DOI: 10.1021/Jm9015284 |
0.355 |
|
| 2010 |
Pandey KK, Snyder JP, Liotta DC, Musaev DG. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP) Journal of Physical Chemistry B. 114: 1127-1135. DOI: 10.1021/jp909945e |
0.344 |
|
| 2009 |
Escuin D, Burke PA, McMahon-Tobin G, Hembrough T, Wang Y, Alcaraz AA, Leandro-García LJ, Rodríguez-Antona C, Snyder JP, Lavallee TM, Giannakakou P. The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression. Cell Cycle (Georgetown, Tex.). 8: 3914-24. PMID 19901556 DOI: 10.4161/Cc.8.23.10105 |
0.533 |
|
| 2009 |
Sun A, Lu YJ, Hu H, Shoji M, Liotta DC, Snyder JP. Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism Bioorganic and Medicinal Chemistry Letters. 19: 6627-6631. PMID 19854644 DOI: 10.1016/J.Bmcl.2009.10.023 |
0.512 |
|
| 2009 |
Ducki S, Mackenzie G, Greedy B, Armitage S, Chabert JF, Bennett E, Nettles J, Snyder JP, Lawrence NJ. Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones. Bioorganic & Medicinal Chemistry. 17: 7711-22. PMID 19837594 DOI: 10.1016/J.Bmc.2009.09.044 |
0.345 |
|
| 2009 |
Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L, Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Cancer and virus leads by HTS, chemical design and SEA data mining. Current Topics in Medicinal Chemistry. 9: 1159-71. PMID 19807668 DOI: 10.2174/156802609789753581 |
0.466 |
|
| 2009 |
Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Research. 69: 6208-15. PMID 19638587 DOI: 10.1158/0008-5472.Can-09-0301 |
0.488 |
|
| 2009 |
Hodge M, Chen QH, Bane S, Sharma S, Loew M, Banerjee A, Alcaraz AA, Snyder JP, Kingston DG. Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation. Bioorganic & Medicinal Chemistry Letters. 19: 2884-7. PMID 19359169 DOI: 10.1016/J.Bmcl.2009.03.063 |
0.61 |
|
| 2009 |
Yang Y, Alcaraz AA, Snyder JP. The tubulin-bound conformation of paclitaxel: T-taxol vs "PTX-NY". Journal of Natural Products. 72: 422-9. PMID 19267457 DOI: 10.1021/Np800662J |
0.608 |
|
| 2009 |
Yuan TH, Jiang Y, Wang XH, Wang DL, Bannerjee A, Bane S, Snyder JP, Lin HX. Synthesis, biological activity and tubulin binding poses of 1-deoxy-9-(R)-dihydrotaxane analogs. Bioorganic & Medicinal Chemistry Letters. 19: 1148-51. PMID 19136258 DOI: 10.1016/J.Bmcl.2008.12.091 |
0.323 |
|
| 2009 |
Thaiparambil J, Bender L, Kline E, Ganesh T, Snyder J, Liotta D, Marcus A. Vimentin: A Novel Chemopreventive Target for Breast Cancer Metastasis. Cancer Research. 69: 5063-5063. DOI: 10.1158/0008-5472.Sabcs-09-5063 |
0.497 |
|
| 2008 |
Chen QH, Ganesh T, Brodie P, Slebodnick C, Jiang Y, Banerjee A, Bane S, Snyder JP, Kingston DG. Design, synthesis and biological evaluation of bridged epothilone D analogues. Organic & Biomolecular Chemistry. 6: 4542-52. PMID 19039362 DOI: 10.1039/B814823F |
0.323 |
|
| 2008 |
Prussia AJ, Plemper RK, Snyder JP. Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance Biochemistry. 47: 13573-13583. PMID 19035834 DOI: 10.1021/Bi801513P |
0.326 |
|
| 2008 |
Ng FM, Geballe MT, Snyder JP, Traynelis SF, Low CM. Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Molecular Brain. 1: 16. PMID 19017396 DOI: 10.1186/1756-6606-1-16 |
0.336 |
|
| 2008 |
Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, ... ... Snyder JP, et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. Journal of Medicinal Chemistry. 51: 5506-21. PMID 18800760 DOI: 10.1021/Jm8002153 |
0.511 |
|
| 2008 |
Thomas SL, Zhong D, Zhou W, Malik S, Liotta D, Snyder JP, Hamel E, Giannakakou P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle (Georgetown, Tex.). 7: 2409-17. PMID 18682687 DOI: 10.4161/Cc.6410 |
0.525 |
|
| 2008 |
Yoon JJ, Chawla D, Paal T, Ndungu M, Du Y, Kurtkaya S, Sun A, Snyder JP, Plemper RK. High-throughput screening-based identification of paramyxovirus inhibitors. Journal of Biomolecular Screening. 13: 591-608. PMID 18626114 DOI: 10.1177/1087057108321089 |
0.31 |
|
| 2008 |
Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Molecular Pharmacology. 74: 654-61. PMID 18577686 DOI: 10.1124/Mol.108.046201 |
0.481 |
|
| 2008 |
Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A. Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Bioorganic & Medicinal Chemistry. 16: 6903-10. PMID 18571929 DOI: 10.1016/J.Bmc.2008.05.047 |
0.499 |
|
| 2008 |
Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA, Alizadeh AR, Liotta DC, Snyder JP. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of Drug Targeting. 16: 185-97. PMID 18365880 DOI: 10.1080/10611860801890093 |
0.479 |
|
| 2008 |
Zhan W, Jiang Y, Brodie PJ, Kingston DGI, Liotta DC, Snyder JP. Design and synthesis C6-C8 bridged epothilone a Organic Letters. 10: 1565-1568. PMID 18355076 DOI: 10.1021/Ol800422Q |
0.475 |
|
| 2007 |
Zhan W, Liang Z, Zhu A, Kurtkaya S, Shim H, Snyder JP, Liotta DC. Discovery of small molecule CXCR4 antagonists Journal of Medicinal Chemistry. 50: 5655-5664. PMID 17958344 DOI: 10.1021/Jm070679I |
0.544 |
|
| 2007 |
Shanker N, Kingston DG, Ganesh T, Yang C, Alcaraz AA, Geballe MT, Banerjee A, McGee D, Snyder JP, Bane S. Enhanced microtubule binding and tubulin assembly properties of conformationally constrained paclitaxel derivatives. Biochemistry. 46: 11514-27. PMID 17892304 DOI: 10.1021/Bi700753Y |
0.593 |
|
| 2007 |
Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/Mol.107.037333 |
0.312 |
|
| 2007 |
Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. Advances in Experimental Medicine and Biology. 595: 77-103. PMID 17569206 DOI: 10.1007/978-0-387-46401-5_2 |
0.527 |
|
| 2007 |
White LK, Yoon JJ, Lee JK, Sun A, Du Y, Fu H, Snyder JP, Plemper RK. Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity. Antimicrobial Agents and Chemotherapy. 51: 2293-303. PMID 17470652 DOI: 10.1128/Aac.00289-07 |
0.317 |
|
| 2007 |
Wang L, Alcaraz AA, Matesanz R, Yang CG, Barasoain I, Díaz JF, Li YZ, Snyder JP, Fang WS. Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues. Bioorganic & Medicinal Chemistry Letters. 17: 3191-4. PMID 17395465 DOI: 10.1016/J.Bmcl.2007.03.026 |
0.597 |
|
| 2007 |
Thepchatri P, Eliseo T, Cicero DO, Myles D, Snyder JP. Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol. Journal of the American Chemical Society. 129: 3127-34. PMID 17323946 DOI: 10.1021/Ja064863P |
0.334 |
|
| 2007 |
Ganesh T, Yang C, Norris A, Glass T, Bane S, Ravindra R, Banerjee A, Metaferia B, Thomas SL, Giannakakou P, Alcaraz AA, Lakdawala AS, Snyder JP, Kingston DG. Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues. Journal of Medicinal Chemistry. 50: 713-25. PMID 17263521 DOI: 10.1021/Jm061071X |
0.605 |
|
| 2007 |
Paik Y, Yang C, Metaferia B, Tang S, Bane S, Ravindra R, Shanker N, Alcaraz AA, Johnson SA, Schaefer J, O'Connor RD, Cegelski L, Snyder JP, Kingston DG. Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation. Journal of the American Chemical Society. 129: 361-70. PMID 17212416 DOI: 10.1021/Ja0656604 |
0.612 |
|
| 2006 |
Tang S, Yang C, Brodie P, Bane S, Ravindra R, Sharma S, Jiang Y, Snyder JP, Kingston DG. Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Organic Letters. 8: 3983-6. PMID 16928054 DOI: 10.1021/Ol061438S |
0.327 |
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| 2006 |
Sun A, Prussia A, Zhan W, Murray EE, Doyle J, Cheng LT, Yoon JJ, Radchenko EV, Palyulin VA, Compans RW, Liotta DC, Plemper RK, Snyder JP. Nonpeptide inhibitors of measles virus entry Journal of Medicinal Chemistry. 49: 5080-5092. PMID 16913698 DOI: 10.1021/Jm0602559 |
0.518 |
|
| 2006 |
Sun A, Shoji M, Lu YJ, Liotta DC, Snyder JP. Synthesis of EF24-tripeptide chloromethyl ketone: A novel curcumin-related anticancer drug delivery system Journal of Medicinal Chemistry. 49: 3153-3158. PMID 16722634 DOI: 10.1021/Jm051141K |
0.491 |
|
| 2006 |
Alcaraz AA, Mehta AK, Johnson SA, Snyder JP. The T-Taxol conformation. Journal of Medicinal Chemistry. 49: 2478-88. PMID 16610791 DOI: 10.1021/Jm051119R |
0.599 |
|
| 2006 |
Jiang Y, Alcaraz AA, Chen JM, Kobayashi H, Lu YJ, Snyder JP. Diastereomers of dibromo-7-epi-10-deacetylcephalomannine: crowded and cytotoxic taxanes exhibit halogen bonds. Journal of Medicinal Chemistry. 49: 1891-9. PMID 16539375 DOI: 10.1021/Jm0509243 |
0.609 |
|
| 2006 |
Hari M, Loganzo F, Annable T, Tan X, Musto S, Morilla DB, Nettles JH, Snyder JP, Greenberger LM. Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Molecular Cancer Therapeutics. 5: 270-8. PMID 16505100 DOI: 10.1158/1535-7163.Mct-05-0190 |
0.303 |
|
| 2006 |
Ganesh T, Norris A, Sharma S, Bane S, Alcaraz AA, Snyder JP, Kingston DG. Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation. Bioorganic & Medicinal Chemistry. 14: 3447-54. PMID 16434198 DOI: 10.1016/J.Bmc.2006.01.002 |
0.597 |
|
| 2006 |
Doyle J, Prussia A, White LK, Sun A, Liotta DC, Snyder JP, Compans RW, Plemper RK. Two domains that control prefusion stability and transport competence of the measles virus fusion protein. Journal of Virology. 80: 1524-36. PMID 16415028 DOI: 10.1128/Jvi.80.3.1524-1536.2006 |
0.492 |
|
| 2005 |
Johnson SA, Alcaraz AA, Snyder JP. T-Taxol and the electron crystallographic density in beta-tubulin. Organic Letters. 7: 5549-52. PMID 16320988 DOI: 10.1021/Ol051780P |
0.585 |
|
| 2005 |
Plemper RK, Doyle J, Sun A, Prussia A, Cheng LT, Rota PA, Liotta DC, Snyder JP, Compans RW. Design of a small-molecule entry inhibitor with activity against primary measles virus strains Antimicrobial Agents and Chemotherapy. 49: 3755-3761. PMID 16127050 DOI: 10.1128/Aac.49.9.3755-3761.2005 |
0.47 |
|
| 2005 |
Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism Anti-Cancer Drugs. 16: 263-275. PMID 15711178 DOI: 10.1097/00001813-200503000-00005 |
0.474 |
|
| 2005 |
Sun A, Lankin DC, Hardcastle K, Snyder JP. 3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: the persistence of axial fluorine. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 1579-91. PMID 15662680 DOI: 10.1002/Chem.200400835 |
0.32 |
|
| 2005 |
Ducki S, Mackenzie G, Lawrence NJ, Snyder JP. Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. Journal of Medicinal Chemistry. 48: 457-65. PMID 15658859 DOI: 10.1021/Jm049444M |
0.356 |
|
| 2005 |
Kingston DG, Bane S, Snyder JP. The taxol pharmacophore and the T-taxol bridging principle. Cell Cycle (Georgetown, Tex.). 4: 279-89. PMID 15611640 DOI: 10.4161/Cc.4.2.1408 |
0.338 |
|
| 2005 |
Liu C, Tamm M, Nötzel MW, Rauch K, De Meijere A, Schilling JK, Lakdawala A, Snyder JP, Bane SL, Shanker N, Ravindra R, Kingston DGI. C-3′-cyclopropanated taxol analogs: Synthesis, bioassay and biostructural analysis European Journal of Organic Chemistry. 3962-3972. DOI: 10.1002/Ejoc.200500243 |
0.357 |
|
| 2004 |
Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science (New York, N.Y.). 305: 866-9. PMID 15297674 DOI: 10.1126/Science.1099190 |
0.31 |
|
| 2004 |
Ganesh T, Guza RC, Bane S, Ravindra R, Shanker N, Lakdawala AS, Snyder JP, Kingston DG. The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs. Proceedings of the National Academy of Sciences of the United States of America. 101: 10006-11. PMID 15226503 DOI: 10.1073/Pnas.0403459101 |
0.326 |
|
| 2004 |
Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkaya S, Camalier RF, Hollingshead MG, Kaur G, Sausville EA, Rickles FR, Snyder JP, Liotta DC, Shoji M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents Bioorganic and Medicinal Chemistry. 12: 3871-3883. PMID 15210154 DOI: 10.1016/J.Bmc.2004.05.006 |
0.516 |
|
| 2004 |
Plemper RK, Erlandson KJ, Lakdawala AS, Sun A, Prussia A, Boonsombat J, Aki-Sener E, Yalcin I, Yildiz I, Temiz-Arpaci O, Tekiner B, Liotta DC, Snyder JP, Compans RW. A target site for template-based design of measles virus entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 5628-5633. PMID 15056763 DOI: 10.1073/Pnas.0308520101 |
0.51 |
|
| 2004 |
Barboni L, Giarlo G, Ricciutelli M, Ballini R, Georg GI, VanderVelde DG, Himes RH, Wang M, Lakdawala A, Snyder JP. Synthesis, modeling, and anti-tubulin activity of a D-seco paclitaxel analogue. Organic Letters. 6: 461-4. PMID 14961598 DOI: 10.1021/Ol036204C |
0.359 |
|
| 2003 |
Checchi PM, Nettles JH, Zhou J, Snyder JP, Joshi HC. Microtubule-interacting drugs for cancer treatment. Trends in Pharmacological Sciences. 24: 361-5. PMID 12871669 DOI: 10.1016/S0165-6147(03)00161-5 |
0.301 |
|
| 2003 |
Ambhaikar NB, Snyder JP, Liotta DC. Diastereoselective addition of chlorotitanium enolate of N-acyl thiazolidinethione to O-methyl oximes: A novel, stereoselective synthesis of α,β-disubstituted β-amino carbonyl compounds via chiral auxiliary mediated azetine formation Journal of the American Chemical Society. 125: 3690-3691. PMID 12656586 DOI: 10.1021/Ja029871U |
0.485 |
|
| 2002 |
Lakdawala AS, Morgan DM, Liotta DC, Lynn DG, Snyder JP. Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates. Journal of the American Chemical Society. 124: 15150-1. PMID 12487571 DOI: 10.1021/Ja0273290 |
0.451 |
|
| 2002 |
Ferstl EM, Venkatesan H, Ambhaikar NB, Snyder JP, Liotta DC. Thiazolidine-2-thione directed diastereoselective addition of chlorotitanium enolates to aldimines Synthesis. 2075-2083. DOI: 10.1055/S-2002-34375 |
0.459 |
|
| 2002 |
Morgan DM, Lynn DG, Lakdawala AS, Snyder JP, Liotta DC. Amyloid structure: Models and theoretical considerations in fibrous aggregates Journal of the Chinese Chemical Society. 49: 459-466. DOI: 10.1002/Jccs.200200072 |
0.457 |
|
| 2001 |
Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study). Bmc Chemical Biology. 1: 2. PMID 11710970 DOI: 10.1186/1472-6769-1-2 |
0.492 |
|
| 2001 |
Metaferia BB, Hoch J, Glass TE, Bane SL, Chatterjee SK, Snyder JP, Lakdawala A, Cornett B, Kingston DG. Synthesis and biological evaluation of novel macrocyclic paclitaxel analogues. Organic Letters. 3: 2461-4. PMID 11483035 DOI: 10.1021/Ol016124D |
0.35 |
|
| 2001 |
Judd DA, Nettles JH, Nevins N, Snyder JP, Liotta DC, Tang J, Ermolieff J, Schinazi RF, Hill CL. Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition Journal of the American Chemical Society. 123: 886-897. PMID 11456622 DOI: 10.1021/Ja001809E |
0.464 |
|
| 2001 |
Monteagudo E, Cicero DO, Cornett B, Myles DC, Snyder JP. The conformations of discodermolide in DMSO Journal of the American Chemical Society. 123: 6929-6930. PMID 11448201 DOI: 10.1021/Ja015569U |
0.342 |
|
| 2001 |
Venkatesan H, Davis MC, Altas Y, Snyder JP, Liotta DC. Total synthesis of SR 121463 A, a highly potent and selective vasopressin V2 receptor antagonist Journal of Organic Chemistry. 66: 3653-3661. PMID 11374981 DOI: 10.1021/Jo0004658 |
0.491 |
|
| 2001 |
Barboni L, Datta A, Dutta D, Georg GI, Vander Velde DG, Himes RH, Wang M, Snyder JP. Novel d-seco paclitaxel analogues: synthesis, biological evaluation, and model testing. The Journal of Organic Chemistry. 66: 3321-9. PMID 11348113 DOI: 10.1021/Jo0015467 |
0.355 |
|
| 2001 |
Barboni L, Lambertucci C, Appendino G, Vander Velde DG, Himes RH, Bombardelli E, Wang M, Snyder JP. Synthesis and NMR-driven conformational analysis of taxol analogues conformationally constrained on the C13 side chain. Journal of Medicinal Chemistry. 44: 1576-87. PMID 11334567 DOI: 10.1021/Jm001103V |
0.342 |
|
| 2001 |
Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E. The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proceedings of the National Academy of Sciences of the United States of America. 98: 5312-6. PMID 11309480 DOI: 10.1073/Pnas.051309398 |
0.334 |
|
| 2001 |
Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study) Bmc Chemical Biology. 1: 1-8. DOI: 10.1186/1472-6769-1-1 |
0.373 |
|
| 2000 |
Wang M, Cornett B, Nettles J, Liotta DC, Snyder JP. The oxetane ring in Taxol Journal of Organic Chemistry. 65: 1059-1068. PMID 10814054 DOI: 10.1021/Jo9916075 |
0.536 |
|
| 2000 |
Snyder JP, Nevins N, Cicero DO, Jansen J. The conformations of taxol in chloroform [7] Journal of the American Chemical Society. 122: 724-725. DOI: 10.1021/Ja9930115 |
0.328 |
|
| 1999 |
Wang M, Xia X, Kim Y, Hwang D, Jansen JM, Botta M, Liotta DC, Snyder JP. A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone Organic Letters. 1: 43-46. PMID 10822530 DOI: 10.1021/Ol990521V |
0.515 |
|
| 1999 |
Nevins N, Cicero D, Snyder JP. A test of the single-conformation hypothesis in the analysis of NMR data for small polar molecules: A force field comparison Journal of Organic Chemistry. 64: 3979-3986. DOI: 10.1021/Jo9824450 |
0.304 |
|
| 1997 |
Weingarten MD, Prein M, Price AT, Snyder JP, Padwa A. Theoretical Insights Regarding the Cycloaddition Behavior of Push-Pull Stabilized Carbonyl Ylides. The Journal of Organic Chemistry. 62: 2001-2010. PMID 11671503 DOI: 10.1021/Jo962184Z |
0.311 |
|
| 1986 |
Biftu T, Gamble NF, Doebber T, Hwang SB, Shen TY, Snyder J, Springer JP, Stevenson R. Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. Journal of Medicinal Chemistry. 29: 1917-1921. PMID 3020247 DOI: 10.1021/Jm00160A020 |
0.322 |
|
| 1981 |
Guttenberger HG, Bestmann HJ, Dickert FL, Jorgensen FS, Snyder JP. Molecules with a helix structure. 3. Sulfur-bridged peri-naphthalenes: synthesis, conformational analysis, and photoelectron spectroscopy of the mono-, di-, and trisulfides of 1,8-dimethylnaphthalene Journal of the American Chemical Society. 103: 159-168. DOI: 10.1021/Ja00391A029 |
0.305 |
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