Bradley Launikonis - Publications

Affiliations: 
Physiology and Biophysics Rush University, Chicago, IL, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Maxwell MJ, Thekkedam C, Lamboley C, Chin YK, Crawford T, Smith JJ, Liu J, Jia X, Vetter I, Laver DR, Launikonis BS, Dulhunty A, Undheim EAB, Mobli M. A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications. 14: 1036. PMID 36823422 DOI: 10.1038/s41467-023-36579-w  0.433
2023 Singh DP, Pearce L, Choi RH, Meizoso-Huesca A, Wette SG, Scott JW, Lamboley CR, Murphy RM, Launikonis BS. Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences of the United States of America. 120: e2117503120. PMID 36649401 DOI: 10.1073/pnas.2117503120  0.803
2022 Seng C, Pearce L, Meizoso-Huesca A, Singh DP, Murphy RM, Lamboley C, Launikonis BS. Tiny changes in cytoplasmic [Ca] cause large changes in mitochondrial Ca: what are the triggers and functional implications? American Journal of Physiology. Cell Physiology. PMID 36094438 DOI: 10.1152/ajpcell.00092.2022  0.749
2022 Barclay CJ, Launikonis BS. Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. The Journal of General Physiology. 154. PMID 35420634 DOI: 10.1085/jgp.20211299404062022c  0.497
2022 Barclay CJ, Launikonis BS. A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. The Journal of General Physiology. 154. PMID 35311921 DOI: 10.1085/jgp.202112994  0.789
2022 Pearce L, Meizoso-Huesca A, Seng C, Lamboley CR, Singh DP, Launikonis BS. Ryanodine receptor activity and store-operated Ca entry: Critical regulators of Ca content and function in skeletal muscle. The Journal of Physiology. PMID 35218018 DOI: 10.1113/JP279512  0.805
2022 Meizoso-Huesca A, Pearce L, Barclay CJ, Launikonis BS. Ca leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35046046 DOI: 10.1073/pnas.2119203119  0.784
2021 Zhang J, Singh DP, Ko CY, Nikolaienko R, Wong King Yuen SM, Schwarz JA, Treinen LM, Tung CC, Rožman K, Svensson B, Aldrich CC, Zima AV, Thomas DD, Bers DM, Launikonis BS, et al. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. The Journal of Biological Chemistry. 101412. PMID 34793835 DOI: 10.1016/j.jbc.2021.101412  0.565
2021 Lamboley CR, Pearce L, Seng C, Meizoso-Huesca A, Singh DP, Frankish BP, Kaura V, Lo HP, Ferguson C, Allen PD, Hopkins PM, Parton RG, Murphy RM, van der Poel C, Barclay CJ, ... Launikonis BS, et al. Ryanodine receptor leak triggers fiber Ca redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances. 7: eabi7166. PMID 34705503 DOI: 10.1126/sciadv.abi7166  0.525
2021 Meizoso-Huesca A, Launikonis BS. The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. The Journal of General Physiology. 153. PMID 33316029 DOI: 10.1085/jgp.202012747  0.81
2021 Meizoso-Huesca A, Launikonis BS. The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. The Journal of General Physiology. 153. PMID 33316029 DOI: 10.1085/jgp.202012747  0.81
2020 Lilliu E, Hilber K, Launikonis BS, Koenig X. Phasic Store-Operated Ca Entry During Excitation-Contraction Coupling in Skeletal Muscle Fibers From Exercised Mice. Frontiers in Physiology. 11: 597647. PMID 33262706 DOI: 10.3389/fphys.2020.597647  0.43
2020 Ferreira JJ, Pequera G, Launikonis BS, Ríos E, Brum G. A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction. The Journal of Physiology. PMID 32991741 DOI: 10.1113/JP279917  0.858
2020 Huerlimann R, Maes GE, Maxwell MJ, Mobli M, Launikonis BS, Jerry DR, Wade NM. Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene. 144765. PMID 32413480 DOI: 10.1016/J.Gene.2020.144765  0.711
2020 Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, et al. A new selective pharmacological enhancer of the Orai1 Ca channel reveals roles for Orai1 in smooth and skeletal muscle functions. Acs Pharmacology & Translational Science. 3: 135-147. PMID 32190822 DOI: 10.1021/acsptsci.9b00081  0.765
2020 Rebbeck RT, Singh DP, Janicek KA, Bers DM, Thomas DD, Launikonis BS, Cornea RL. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca assays. Scientific Reports. 10: 1791. PMID 32019969 DOI: 10.1038/S41598-020-58461-1  0.677
2020 Singh DP, Watt MJ, Launikonis BS. Effects of Diet Induced Obesity on Rat Skeletal Muscle Ca2+ Handling and Cellular Adaptations Biophysical Journal. 118: 408a. DOI: 10.1016/j.bpj.2019.11.2309  0.495
2019 Koenig X, Choi RH, Schicker K, Singh DP, Hilber K, Launikonis BS. Mechanistic insights into store-operated Ca entry during excitation-contraction coupling in skeletal muscle. Biochimica Et Biophysica Acta. Molecular Cell Research. PMID 30825472 DOI: 10.1016/j.bbamcr.2019.02.014  0.815
2019 Barclay CJ, Launikonis BS. Determination of Heat Production in Human Skeletal Muscle from Measurements of Basal Ca2+ Movements Biophysical Journal. 116: 520a. DOI: 10.1016/j.bpj.2018.11.2805  0.522
2018 Koenig X, Choi RH, Launikonis BS. Store-operated Ca entry is activated by every action potential in skeletal muscle. Communications Biology. 1: 31. PMID 30271917 DOI: 10.1038/s42003-018-0033-7  0.8
2018 Cully TR, Choi RH, Bjorksten AR, Stephenson DG, Murphy RM, Launikonis BS. Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30038012 DOI: 10.1073/pnas.1800490115  0.662
2018 Koenig X, Launikonis BS. Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle Biophysical Journal. 114: 40a-41a. DOI: 10.1016/j.bpj.2017.11.272  0.619
2017 Bakker AJ, Cully TR, Wingate CD, Barclay CJ, Launikonis BS. Doublet stimulation increases Ca(2+) binding to troponin C to ensure rapid force development in skeletal muscle. The Journal of General Physiology. PMID 28209802 DOI: 10.1085/jgp.201611727  0.772
2017 Cully TR, Murphy RM, Roberts L, Raastad T, Fassett RG, Coombes JS, Jayasinghe ID, Launikonis BS. Human skeletal muscle plasmalemma alters its structure to change its Ca(2+)-handling following heavy-load resistance exercise. Nature Communications. 8: 14266. PMID 28193999 DOI: 10.1038/ncomms14266  0.731
2016 Cully TR, Launikonis BS. Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology. Cell Physiology. 310: C673-80. PMID 26825125 DOI: 10.1152/ajpcell.00366.2015  0.685
2016 Cully TR, Edwards JN, Murphy RM, Launikonis BS. A quantitative description of tubular system Ca(2+) handling in fast- and slow-twitch muscle fibres. The Journal of Physiology. 594: 2795-810. PMID 26775687 DOI: 10.1113/JP271658  0.699
2016 Cully TR, Edwards JN, Murphy RM, Launikonis BS. A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres Journal of Physiology. DOI: 10.1113/JP271658  0.673
2016 Cully TR, Launikonis BS. The T-System Provides a Dynamic Ca2+-Buffer in Human Skeletal Muscle Fibres Biophysical Journal. 110: 598a. DOI: 10.1016/j.bpj.2015.11.3193  0.581
2016 Cully TR, Choi RH, Shannon TR, Launikonis BS. Ryanodine Receptor Activity Regulates the Levels of Ca2+ Extrusion and Store-Operated Ca2+ Entry in Skeletal Muscle Biophysical Journal. 110: 183a. DOI: 10.1016/j.bpj.2015.11.1019  0.724
2015 Cully TR, Launikonis BS. Determination of the Junctional Space [Ca2+] Set by Ryanodine Receptor Leak in Slow- and Fast-Twitch Muscle Fibres Biophysical Journal. 108: 270a. DOI: 10.1016/j.bpj.2014.11.1483  0.579
2014 Jayasinghe ID, Munro M, Baddeley D, Launikonis BS, Soeller C. Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging. Journal of the Royal Society, Interface. 11. PMID 25100314 DOI: 10.1098/rsif.2014.0570  0.427
2014 Cully TR, Edwards JN, Launikonis BS. Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. The Journal of Physiology. 592: 3727-46. PMID 24973406 DOI: 10.1113/jphysiol.2014.274274  0.819
2014 Cully TR, Edwards JN, Shannon TR, Launikonis B. Ca2+ Uptake by the Tubular (T-) System Membrane of Rat Fast-Twitch Fibres Biophysical Journal. 106: 126a-127a. DOI: 10.1016/J.Bpj.2013.11.749  0.789
2014 Jayasinghe ID, Munro M, Baddeley D, Launikonis BS, Soeller C. Resolving the Calcium Release Machinery of Mammalian Fast- and Slow-Twitch Skeletal Muscle Biophysical Journal. 106: 123a-124a. DOI: 10.1016/j.bpj.2013.11.736  0.356
2014 Ferreira JJ, Pequera G, Launikonis B, Ríos E, Brum G. A Chloride Channel Blocker Prevents Inorganic Phosphate Accumulation and Its Effects in the Sarcoplasmic Reticulum of Frog Permeabilized Skeletal Muscle Fibers Biophysical Journal. 106: 533a. DOI: 10.1016/J.Bpj.2013.11.2975  0.854
2013 Jayasinghe ID, Launikonis BS. Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle. Journal of Cell Science. 126: 4048-58. PMID 23813954 DOI: 10.1242/jcs.131565  0.418
2013 Cully TR, Launikonis BS. Store-operated Ca²⁺ entry is not required for store refilling in skeletal muscle. Clinical and Experimental Pharmacology & Physiology. 40: 338-44. PMID 23517302 DOI: 10.1111/1440-1681.12078  0.302
2013 Cully TR, Launikonis BS. Store-Operated Ca2+ Entry is a Tonic and Phasic Signal in Skeletal Muscle Biophysical Journal. 104: 607a. DOI: 10.1016/j.bpj.2012.11.3364  0.627
2012 Cully TR, Edwards JN, Friedrich O, Stephenson DG, Murphy RM, Launikonis BS. Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca(2+) signaling in dystrophic mdx mouse muscle. American Journal of Physiology. Cell Physiology. 303: C567-76. PMID 22785116 DOI: 10.1152/ajpcell.00144.2012  0.755
2012 Edwards JN, Cully TR, Shannon TR, Stephenson DG, Launikonis BS. Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy Journal of Physiology. 590: 475-492. PMID 22155929 DOI: 10.1113/jphysiol.2011.221796  0.48
2012 Cully TR, Edwards JN, Murphy RM, Launikonis BS. Different Capacity for Store-Operated Ca2+ Entry and Ca2+ Extrusion Across the Plasma Membrane of Wild-Type and Dystrophic mdx Mouse Muscle Biophysical Journal. 102: 365a. DOI: 10.1016/j.bpj.2011.11.1989  0.67
2011 Edwards JN, Blackmore DG, Gilbert DF, Murphy RM, Launikonis BS. Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression. Aging Cell. 10: 675-85. PMID 21418512 DOI: 10.1111/j.1474-9726.2011.00706.x  0.537
2011 Edwards JN, Cully TR, Shannon TR, Launikonis BS. Using Superfast Confocal Microscopy to Measure the Ca2+ Release Waveform and Spread of Excitation throughout the Tubular Network in Mammalian Skeletal Muscle Biophysical Journal. 100: 590a. DOI: 10.1016/j.bpj.2010.12.3403  0.633
2011 Edwards JN, Launikonis BS. Extrusion of Ca2+ Across the Tubular System Membrane is Dependent on Membrane Potential and the Cytoplasmic Ca2+ in Rat Skeletal Muscle Biophysical Journal. 100: 590a. DOI: 10.1016/j.bpj.2010.12.3402  0.626
2010 Launikonis BS, Murphy RM, Edwards JN. Toward the roles of store-operated Ca2+ entry in skeletal muscle Pflugers Archiv European Journal of Physiology. 460: 813-823. PMID 20577885 DOI: 10.1007/s00424-010-0856-7  0.758
2010 Edwards JN, Murphy RM, Cully TR, von Wegner F, Friedrich O, Launikonis BS. Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle Cell Calcium. 47: 458-467. PMID 20434768 DOI: 10.1016/j.ceca.2010.04.001  0.809
2010 Edwards JN, Friedrich O, Cully TR, Von Wegner F, Murphy RM, Launikonis BS. Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle American Journal of Physiology - Cell Physiology. 299: C42-C50. PMID 20427714 DOI: 10.1152/ajpcell.00524.2009  0.761
2010 Edwards JN, Cully TR, von Wegner F, Friedrich O, Thorn P, Launikonis BS. Superfast Confocal Imaging of Ca2+ Reveals the Spread of Excitation Through the Tubular Network and the Ca2+ Release Waveform in Skeletal Muscle Biophysical Journal. 98: 202a. DOI: 10.1016/j.bpj.2009.12.1078  0.755
2009 Launikonis BS, Stephenson DG, Friedrich O. Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle Journal of Physiology. 587: 2299-2312. PMID 19332499 DOI: 10.1113/jphysiol.2009.168682  0.78
2009 Launikonis BS, Edwards JN, von Wegner F, Friedrich O. Store-operated Ca2+ Entry In Skeletal Muscle Can Be Activated And Deactivated Within Milliseconds Of Ca2+ Release And Store Refilling Biophysical Journal. 96: 280a. DOI: 10.1016/J.BPJ.2008.12.1384  0.784
2009 Launikonis BS, Stephenson DG, Edwards JN, Murphy RM, Friedrich O. Tightly Regulated Store-operated Ca2+ Entry In Healthy And Dystrophic Skeletal Muscle Biophysical Journal. 96: 279a. DOI: 10.1016/j.bpj.2008.12.1383  0.639
2009 Teichmann MD, von Wegner F, Fink RH, Chamberlain JS, Launikonis BS, Martinac B, Friedrich O. Ca2+ Spark Activity in Intact Dystrophin-Deficient mdx Muscle during Osmotic Challenge is Triggered by Mechanosensitive Pathways Biophysical Journal. 96: 22a-23a. DOI: 10.1016/J.Bpj.2008.12.1018  0.673
2008 Teichmann MD, Wegner FV, Fink RH, Chamberlain JS, Launikonis BS, Martinac B, Friedrich O. Inhibitory control over Ca(2+) sparks via mechanosensitive channels is disrupted in dystrophin deficient muscle but restored by mini-dystrophin expression. Plos One. 3: e3644. PMID 18982068 DOI: 10.1371/Journal.Pone.0003644  0.797
2008 Ríos E, Zhou J, Brum G, Launikonis BS, Stern MD. Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. The Journal of General Physiology. 131: 335-48. PMID 18347079 DOI: 10.1085/Jgp.200709870  0.858
2007 Launikonis BS, Ríos E. Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. The Journal of Physiology. 583: 81-97. PMID 17569733 DOI: 10.1113/Jphysiol.2007.135046  0.884
2006 Ríos E, Launikonis BS, Royer L, Brum G, Zhou J. The elusive role of store depletion in the control of intracellular calcium release. Journal of Muscle Research and Cell Motility. 27: 337-50. PMID 16933025 DOI: 10.1007/S10974-006-9082-5  0.83
2006 Launikonis BS, Zhou J, Santiago D, Brum G, Ríos E. The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle. The Journal of General Physiology. 128: 45-54. PMID 16769796 DOI: 10.1085/Jgp.200609545  0.837
2006 Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proceedings of the National Academy of Sciences of the United States of America. 103: 2982-7. PMID 16473932 DOI: 10.1073/Pnas.0511252103  0.84
2006 Zhou J, Yi J, Royer L, Launikonis BS, González A, García J, Ríos E. A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle. American Journal of Physiology. Cell Physiology. 290: C539-53. PMID 16148029 DOI: 10.1152/Ajpcell.00592.2004  0.822
2005 Zhou J, Brum G, González A, Launikonis BS, Stern MD, Ríos E. Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. The Journal of General Physiology. 126: 301-9. PMID 16186560 DOI: 10.1085/Jgp.200509353  0.846
2005 Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. The Journal of Physiology. 567: 523-43. PMID 15946962 DOI: 10.1113/Jphysiol.2005.087973  0.837
2004 Zhou J, Launikonis BS, Ríos E, Brum G. Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling? The Journal of General Physiology. 124: 409-28. PMID 15452201 DOI: 10.1085/Jgp.200409105  0.873
2003 Launikonis BS, Barnes M, Stephenson DG. Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor Proceedings of the National Academy of Sciences of the United States of America. 100: 2941-2944. PMID 12601149 DOI: 10.1073/pnas.0536227100  0.698
2001 Launikonis BS, Stephenson DG. Effects of membrane cholesterol manipulation on excitation-contraction coupling in skeletal muscle of the toad. The Journal of Physiology. 534: 71-85. PMID 11432993 DOI: 10.1111/J.1469-7793.2001.00071.X  0.415
2000 Launikonis BS, Stephenson DG. Effects of Mg2+ on Ca2+ release from sarcoplasmic reticulum of skeletal muscle fibres from yabby (crustacean) and rat Journal of Physiology. 526: 299-312. PMID 10896719 DOI: 10.1111/J.1469-7793.2000.00299.X  0.784
1997 Launikonis BS, Stephenson DG. Effect of saponin treatment on the sarcoplasmic reticulum of rat, cane toad and crustacean (yabby) skeletal muscle Journal of Physiology. 504: 425-437. PMID 9365915 DOI: 10.1111/j.1469-7793.1997.425be.x  0.718
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