| Year |
Citation |
Score |
| Low-probability matches (unlikely to be authored by this person) |
| 2024 |
Santos M, Michael PL, Mitchell T, Lam Y, Robinson T, Moore M, Tan RP, Rnjak-Kovacina J, Lim KS, Wise SG. On-Demand Bioactivation of Inert Materials with Plasma-Polymerized Nanoparticles. Advanced Materials (Deerfield Beach, Fla.). e2311313. PMID 38483292 DOI: 10.1002/adma.202311313 |
0.01 |
|
| 2023 |
Dowling AV, Seitzman BA, Mitchell TJ, Olufawo M, Dierker DL, Anandarajah H, Dworetsky A, McMichael A, Jiang C, Barbour DL, Schlaggar BL, Limbrick DD, Strahle JM, Rubin JB, Shimony JS, et al. Cognition and Brain System Segregation in Pediatric Brain Tumor Patients Treated with Proton Therapy. International Journal of Particle Therapy. 10: 32-42. PMID 37823016 DOI: 10.14338/IJPT-22-00039.1 |
0.01 |
|
| 2023 |
Seitzman BA, Reynoso FJ, Mitchell TJ, Bice AR, Jarang A, Wang X, Mpoy C, Strong L, Rogers BE, Yuede CM, Rubin JB, Perkins SM, Bauer AQ. Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice. Geroscience. PMID 37749370 DOI: 10.1007/s11357-023-00944-w |
0.01 |
|
| 2023 |
Xin H, Romanazzo S, Tomaskovic-Crook E, Mitchell TC, Hung JC, Wise SG, Cheng K, Al Maruf DSA, Stokan MJ, Manzie TGH, Parthasarathi K, Cheung VKY, Gupta R, Ly M, Pulitano C, et al. Ex Vivo Preservation of Ovine Periosteum Using a Perfusion Bioreactor System. Cells. 12. PMID 37443758 DOI: 10.3390/cells12131724 |
0.01 |
|
| 2023 |
Bodensteiner BL, Iverson JB, Lea CA, Milne-Zelman CL, Mitchell TS, Refsnider JM, Voves K, Warner DA, Janzen FJ. Mother knows best: nest-site choice homogenizes embryo thermal environments among populations in a widespread ectotherm. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220155. PMID 37427473 DOI: 10.1098/rstb.2022.0155 |
0.01 |
|
| 2023 |
Baronti D, Tomov N, Hupp S, Mitchell TJ, Iliev AI. Dendritic spine loss deep in the neocortex and dendrite distortion with diffusion disturbances occur early in experimental pneumococcal meningitis. Frontiers in Neuroscience. 16: 912445. PMID 36704002 DOI: 10.3389/fnins.2022.912445 |
0.01 |
|
| 2022 |
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, ... ... Mitchell TJ, et al. Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Science Translational Medicine. 14: eabg8577. PMID 36475904 DOI: 10.1126/scitranslmed.abg8577 |
0.01 |
|
| 2022 |
Mitchell TC, Feng NL, Lam YT, Michael P, Santos M, Wise SG. Engineering vascular bioreactor systems to closely mimic physiological forces in vitro. Tissue Engineering. Part B, Reviews. PMID 36274223 DOI: 10.1089/ten.TEB.2022.0158 |
0.01 |
|
| 2022 |
Hupp S, Förtsch C, Graber F, Mitchell TJ, Iliev AI. Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis. Nature Communications. 13: 5032. PMID 36028511 DOI: 10.1038/s41467-022-32624-2 |
0.01 |
|
| 2022 |
Fargevieille A, Reedy AM, Kahrl AF, Mitchell TS, Durso AM, Delaney DM, Pearson PR, Cox RM, Warner DA. Propagule size and sex ratio influence colonisation dynamics after introduction of a non-native lizard. The Journal of Animal Ecology. PMID 35114034 DOI: 10.1111/1365-2656.13671 |
0.01 |
|
| 2021 |
Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M. Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure. Cells. 10. PMID 34944089 DOI: 10.3390/cells10123581 |
0.01 |
|
| 2021 |
Doyle-Baker PK, Mitchell T, Hayden KA. Stroke and Athletes: A Scoping Review. International Journal of Environmental Research and Public Health. 18. PMID 34639349 DOI: 10.3390/ijerph181910047 |
0.01 |
|
| 2021 |
Shephard AM, Mitchell TS, Snell-Rood EC. Monarch caterpillars are robust to combined exposure to the roadside micronutrients sodium and zinc. Conservation Physiology. 9: coab061. PMID 34386239 DOI: 10.1093/conphys/coab061 |
0.01 |
|
| 2021 |
Cole J, Angyal A, Emes RD, Mitchell TJ, Dickman MJ, Dockrell DH. Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages. Frontiers in Immunology. 12: 573266. PMID 34046027 DOI: 10.3389/fimmu.2021.573266 |
0.01 |
|
| 2021 |
Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M. Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst. Scientific Reports. 11: 9529. PMID 33953279 DOI: 10.1038/s41598-021-88897-y |
0.01 |
|
| 2021 |
Panagiotou S, Chaguza C, Yahya R, Audshasai T, Baltazar M, Ressel L, Khandaker S, Alsahag M, Mitchell TJ, Prudhomme M, Kadioglu A, Yang M. Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific Reports. 11: 6658. PMID 33731755 DOI: 10.1038/s41598-021-86214-1 |
0.01 |
|
| 2021 |
Lokken EM, Taylor GG, Huebner EM, Vanderhoeven J, Hendrickson S, Coler B, Sheng JS, Walker CL, McCartney SA, Kretzer NM, Resnick R, Kachikis A, Barnhart N, Schulte V, Bergam B, ... ... Mitchell T, et al. Higher SARS-CoV-2 Infection Rate in Pregnant Patients. American Journal of Obstetrics and Gynecology. PMID 33607103 DOI: 10.1016/j.ajog.2021.02.011 |
0.01 |
|
| 2021 |
Lokken EM, Huebner EM, Taylor GG, Hendrickson S, Vanderhoeven J, Kachikis A, Coler B, Walker CL, Sheng JS, Al-Haddad BJS, McCartney SA, Kretzer NM, Resnick R, Barnhart N, Schulte V, ... ... Mitchell T, et al. Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State. American Journal of Obstetrics and Gynecology. PMID 33515516 DOI: 10.1016/j.ajog.2020.12.1221 |
0.01 |
|
| 2020 |
Kennedy WR, DeWees TA, Acharya S, Mahmood M, Knutson NC, Goddu SM, Kavanaugh JA, Mitchell TJ, Rich KM, Kim AH, Leuthardt EC, Dowling JL, Dunn GP, Chicoine MR, Perkins SM, et al. Internal dose escalation associated with increased local control for melanoma brain metastases treated with stereotactic radiosurgery. Journal of Neurosurgery. 1-7. PMID 33307528 DOI: 10.3171/2020.7.JNS192210 |
0.01 |
|
| 2020 |
Maraghechi B, Kim T, Mitchell TJ, Goddu SM, Dise J, Kavanaugh JA, Zoberi JE, Mutic S, Knutson NC. Filmless quality assurance of a Leksell Gamma Knife® Icon™. Journal of Applied Clinical Medical Physics. PMID 33300664 DOI: 10.1002/acm2.13070 |
0.01 |
|
| 2020 |
Badgujar DC, Anil A, Green AE, Surve MV, Madhavan S, Beckett A, Prior IA, Godsora BK, Patil SB, More PK, Sarkar SG, Mitchell A, Banerjee R, Phale PS, Mitchell TJ, et al. Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. Plos Pathogens. 16: e1009016. PMID 33216805 DOI: 10.1371/journal.ppat.1009016 |
0.01 |
|
| 2020 |
Panagiotou S, Chaguza C, Yahya R, Audshasai T, Baltazar M, Ressel L, Khandaker S, Alsahag M, Mitchell TJ, Prudhomme M, Kadioglu A, Yang M. Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific Reports. 10: 17313. PMID 33057054 DOI: 10.1038/s41598-020-73454-w |
0.01 |
|
| 2020 |
Nerlich A, von Wunsch Teruel I, Mieth M, Hönzke K, Rückert JC, Mitchell TJ, Suttorp N, Hippenstiel S, Hocke AC. Reversion of pneumolysin induced executioner caspase activation redirects cells to survival. The Journal of Infectious Diseases. PMID 33045080 DOI: 10.1093/infdis/jiaa639 |
0.01 |
|
| 2020 |
Watson K, Russell CD, Baillie JK, Dhaliwal K, Fitzgerald JR, Mitchell TJ, Simpson AJ, Renshaw SA, Dockrell DH. Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance. Frontiers in Immunology. 11: 786. PMID 32582139 DOI: 10.3389/fimmu.2020.00786 |
0.01 |
|
| 2020 |
Mitchell TS, Agnew L, Meyer R, Sikkink KL, Oberhauser KS, Borer ET, Snell-Rood EC. Traffic influences nutritional quality of roadside plants for monarch caterpillars. The Science of the Total Environment. 724: 138045. PMID 32408428 DOI: 10.1016/J.Scitotenv.2020.138045 |
0.01 |
|
| 2020 |
Hall JM, Mitchell TS, Thawley CJ, Stroud JT, Warner DA. Adaptive seasonal shift towards investment in fewer, larger offspring: Evidence from field and laboratory studies. The Journal of Animal Ecology. PMID 31994721 DOI: 10.1111/1365-2656.13182 |
0.01 |
|
| 2020 |
Mitchell T, Seitzman B, Ballard N, Petersen SE, Shimony J, Leuthardt E. Human brain functional network organization is disrupted following whole-brain radiation therapy. Brain Connectivity. PMID 31964163 DOI: 10.1089/Brain.2019.0713 |
0.01 |
|
| 2020 |
Prusator MT, Zhao T, Kavanaugh JA, Santanam L, Dise J, Goddu SM, Mitchell TJ, Zoberi JE, Kim T, Mutic S, Knutson NC. Evaluation of a new secondary dose calculation software for Gamma Knife radiosurgery. Journal of Applied Clinical Medical Physics. 21: 95-102. PMID 31943756 DOI: 10.1002/Acm2.12794 |
0.01 |
|
| 2020 |
Warner DA, Mitchell TS, Bodensteiner BL, Janzen FJ. Sex and Incubation Temperature Independently Affect Embryonic Development and Offspring Size in a Turtle with Temperature-Dependent Sex Determination. Physiological and Biochemical Zoology : Pbz. 93: 62-74. PMID 31808735 DOI: 10.1086/706786 |
0.01 |
|
| 2019 |
Fanter CE, Lin Z, Keenan SW, Janzen FJ, Mitchell TS, Warren DE. Development-specific transcriptomic profiling suggests new mechanisms for anoxic survival in the ventricle of overwintering turtles. The Journal of Experimental Biology. PMID 31862849 DOI: 10.1242/Jeb.213918 |
0.01 |
|
| 2019 |
Hupp S, Grandgirard D, Mitchell TJ, Leib SL, Hathaway LJ, Iliev AI. Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia. Journal of Neuroinflammation. 16: 105. PMID 31103037 DOI: 10.1186/s12974-019-1491-7 |
0.01 |
|
| 2019 |
Knutson NC, Hawkins BJ, Bollinger D, Goddu SM, Kavanaugh JA, Santanam L, Mitchell TJ, Zoberi JE, Tsien C, Huang J, Robinson CG, Perkins SM, Dowling JL, Chicoine MR, Rich KM, et al. Characterization and validation of an intra-fraction motion management system for masked-based radiosurgery. Journal of Applied Clinical Medical Physics. PMID 31055877 DOI: 10.1002/Acm2.12573 |
0.01 |
|
| 2019 |
Janzen FJ, Delaney DM, Mitchell TS, Warner DA. Do covariances between maternal behavior and embryonic physiology drive sex-ratio evolution under environmental sex determination? The Journal of Heredity. PMID 30982894 DOI: 10.1093/jhered/esz021 |
0.01 |
|
| 2019 |
Bodensteiner BL, Warner DA, Iverson JB, Milne-Zelman CL, Mitchell TS, Refsnider JM, Janzen FJ. Geographic variation in thermal sensitivity of early life traits in a widespread reptile. Ecology and Evolution. 9: 2791-2802. PMID 30891217 DOI: 10.1002/ece3.4956 |
0.01 |
|
| 2019 |
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, et al. Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia. American Journal of Respiratory and Critical Care Medicine. PMID 30649895 DOI: 10.1164/Rccm.201804-0646Oc |
0.01 |
|
| 2019 |
Li C, Bademci G, Subasioglu A, Diaz-Horta O, Zhu Y, Liu J, Mitchell TG, Abad C, Seyhan S, Duman D, Cengiz FB, Tokgoz-Yilmaz S, Blanton SH, Farooq A, Walz K, et al. Dysfunction of , encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. Proceedings of the National Academy of Sciences of the United States of America. PMID 30610177 DOI: 10.1073/Pnas.1810951116 |
0.01 |
|
| 2018 |
Maurer J, Hupp S, Pillich H, Mitchell TJ, Chakraborty T, Iliev AI. Missing elimination via membrane vesicle shedding contributes to the diminished calcium sensitivity of listeriolysin O. Scientific Reports. 8: 15846. PMID 30367146 DOI: 10.1038/s41598-018-34031-4 |
0.01 |
|
| 2018 |
Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A. Th17 responses to pneumococcus in blood and adenoidal cells in children. Clinical and Experimental Immunology. PMID 30325010 DOI: 10.1111/cei.13225 |
0.01 |
|
| 2018 |
Köffel R, Wolfmeier H, Larpin Y, Besançon H, Schoenauer R, Babiychuk VS, Drücker P, Pabst T, Mitchell TJ, Babiychuk EB, Draeger A. Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses. Frontiers in Immunology. 9: 1688. PMID 30100903 DOI: 10.3389/fimmu.2018.01688 |
0.01 |
|
| 2018 |
Mitchell TS, Janzen FJ, Warner DA. Quantifying the effects of embryonic phenotypic plasticity on adult phenotypes in reptiles: A review of current knowledge and major gaps. Journal of Experimental Zoology. Part a, Ecological and Integrative Physiology. PMID 29869377 DOI: 10.1002/jez.2187 |
0.01 |
|
| 2018 |
Ritchie ND, Ritchie R, Bayes HK, Mitchell TJ, Evans TJ. IL-17 can be protective or deleterious in murine pneumococcal pneumonia. Plos Pathogens. 14: e1007099. PMID 29813133 DOI: 10.1371/journal.ppat.1007099 |
0.01 |
|
| 2018 |
Herbert JA, Kay EJ, Faustini SE, Richter A, Abouelhadid S, Cuccui J, Wren B, Mitchell TJ. Production and efficacy of a low-cost recombinant pneumococcal protein polysaccharide conjugate vaccine. Vaccine. PMID 29778517 DOI: 10.1016/j.vaccine.2018.05.036 |
0.01 |
|
| 2018 |
Mitchell T, MacDonald JW, Srinouanpranchanh S, Bammler TK, Merillat S, Boldenow E, Coleman M, Agnew K, Baldessari A, Stencel-Baerenwald JE, Tisoncik-Go J, Green RR, Gale MJ, Rajagopal L, Adams Waldorf KM. Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. American Journal of Obstetrics and Gynecology. PMID 29475580 DOI: 10.1016/j.ajog.2018.01.009 |
0.01 |
|
| 2018 |
Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. American Journal of Respiratory and Critical Care Medicine. PMID 29447449 DOI: 10.1164/rccm.201708-1733OC |
0.01 |
|
| 2018 |
Herbert JA, Mitchell AM, Ritchie R, Ma J, Ross-Hutchinson K, Mitchell TJ. Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. Plos One. 13: e0189426. PMID 29342160 DOI: 10.1371/journal.pone.0189426 |
0.01 |
|
| 2018 |
Morozov GI, Porat N, Kushnir T, Najmuldeen H, Adawi A, Chalifa-Caspi V, Benisty R, Ohayon A, Liron O, Azriel S, Malka I, Dotan S, Portnoi M, Piotrowski AA, Kafka D, ... ... Mitchell TJ, et al. Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge. Scientific Reports. 8: 314. PMID 29321514 DOI: 10.1038/S41598-017-18645-8 |
0.01 |
|
| 2018 |
Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Imai-Matsushima A, Meyer TF, Paasch L, Mitchell TJ, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, et al. Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA. Scientific Reports. 8: 182. PMID 29317705 DOI: 10.1038/S41598-017-18468-7 |
0.01 |
|
| 2018 |
Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, ... Mitchell TJ, et al. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Critical Care Medicine. PMID 29298188 DOI: 10.1097/CCM.0000000000002916 |
0.01 |
|
| 2018 |
Letsiou E, Teixeira Alves L, Felten M, Mitchell T, Müller-Redetzky H, Witzenrath M. Neutrophils produce microvesicles in pneumococcal pneumonia Pneumologie. 72: S95-S96. DOI: 10.1055/S-0037-1619374 |
0.01 |
|
| 2017 |
Hulbert AC, Mitchell TS, Hall JM, Guiffre CM, Douglas DC, Warner DA. The effects of incubation temperature and experimental design on heart rates of lizard embryos. Journal of Experimental Zoology. Part a, Ecological and Integrative Physiology. 327: 466-476. PMID 29356429 DOI: 10.1002/jez.2135 |
0.01 |
|
| 2017 |
Warner DA, Mitchell TS, Bodensteiner BL, Janzen FJ. The effect of hormone manipulations on sex ratios varies with environmental conditions in a turtle with temperature-dependent sex determination. Journal of Experimental Zoology. Part a, Ecological and Integrative Physiology. 327: 172-181. PMID 29356364 DOI: 10.1002/jez.2085 |
0.01 |
|
| 2017 |
Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Critical Care (London, England). 21: 274. PMID 29132435 DOI: 10.1186/s13054-017-1851-6 |
0.01 |
|
| 2017 |
Hupp S, Ribes S, Seele J, Bischoff C, Förtsch C, Maier E, Benz R, Mitchell TJ, Nau R, Iliev AI. Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation. British Journal of Pharmacology. PMID 28888095 DOI: 10.1111/bph.14027 |
0.01 |
|
| 2017 |
Brown LA, Mitchell AM, Mitchell TJ. Streptococcus pneumoniae and lytic antibiotic therapy: are we adding insult to injury during invasive pneumococcal disease and sepsis? Journal of Medical Microbiology. PMID 28792379 DOI: 10.1099/jmm.0.000545 |
0.01 |
|
| 2017 |
Lizcano A, Suresh Babu RA, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, Orihuela CJ. Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties. Microbes and Infection. PMID 28408270 DOI: 10.1016/J.Micinf.2017.04.001 |
0.01 |
|
| 2017 |
Nel JG, Durandt C, Theron AJ, Tintinger GR, Pool R, Richards GA, Mitchell TJ, Feldman C, Anderson R. Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro. The Journal of Infection. PMID 28267572 DOI: 10.1016/j.jinf.2017.02.010 |
0.01 |
|
| 2017 |
Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI. Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes. Toxins. 9. PMID 28098781 DOI: 10.3390/toxins9010034 |
0.01 |
|
| 2016 |
Wolfmeier H, Radecke J, Schoenauer R, Koeffel R, Babiychuk VS, Drücker P, Hathaway LJ, Mitchell TJ, Zuber B, Draeger A, Babiychuk EB. Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack. Biochimica Et Biophysica Acta. PMID 27481675 DOI: 10.1016/j.bbagen.2016.07.022 |
0.01 |
|
| 2016 |
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B. NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence. Scientific Reports. 6: 30943. PMID 27476670 DOI: 10.1038/srep30943 |
0.01 |
|
| 2016 |
Telemeco RS, Gangloff EJ, Cordero GA, Mitchell TS, Bodensteiner BL, Holden KG, Mitchell SM, Polich RL, Janzen FJ. Reptile Embryos Lack the Opportunity to Thermoregulate by Moving within the Egg. The American Naturalist. 188: E13-E27. PMID 27322129 DOI: 10.1086/686628 |
0.01 |
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| 2016 |
Mubarak A, Ahmed MS, Upile N, Vaughan C, Xie C, Sharma R, Acar P, McCormick MS, Paton JC, Mitchell T, Cunliffe N, Zhang Q. A dynamic relationship between mucosal Th17 and Treg populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. PMID 27256063 DOI: 10.1016/j.cmi.2016.05.017 |
0.01 |
|
| 2016 |
Nel JG, Durandt C, Mitchell TJ, Feldman C, Anderson R, Tintinger GR. Pneumolysin Mediates Platelet Activation In Vitro. Lung. PMID 27192991 DOI: 10.1007/s00408-016-9900-5 |
0.01 |
|
| 2016 |
Mizrachi Nebenzahl Y, Blau K, Kushnir T, Shagan M, Portnoi M, Cohen A, Azriel S, Malka I, Adawi A, Kafka D, Dotan S, Guterman G, Troib S, Fishilevich T, Gershoni JM, ... ... Mitchell TJ, et al. Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine. Plos One. 11: e0150320. PMID 26990554 DOI: 10.1371/Journal.Pone.0150320 |
0.01 |
|
| 2016 |
Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, Winlove CP. Red Blood Cell Susceptibility to Pneumolysin: Correlation with Membrane Biochemical and Physical Properties. The Journal of Biological Chemistry. PMID 26984406 DOI: 10.1074/jbc.M115.691899 |
0.01 |
|
| 2016 |
Nel JG, Theron AJ, Durandt C, Tintinger GR, Pool R, Mitchell TJ, Feldman C, Anderson R. Pneumolysin activates neutrophil extracellular trap formation. Clinical and Experimental Immunology. PMID 26749379 DOI: 10.1111/cei.12766 |
0.01 |
|
| 2016 |
Nel J, Durandt C, Theron A, Tintinger G, Mitchell T, Feldman C, Anderson R. S47 Pneumolysin promotes neutrophil: platelet aggregation in vitro Thorax. 71: A29.1-A29. DOI: 10.1136/thoraxjnl-2016-209333.53 |
0.01 |
|
| 2016 |
Gutbier B, Jiang X, Ehrler C, Mitchell T, Weissmann N, Van Slyke P, Dumont D, Suttorp N, Witzenrath M. The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-induced Barrier Disruption Pneumologie. 70. DOI: 10.1055/S-0036-1572079 |
0.01 |
|
| 2015 |
Leuthardt EC, Allen M, Kamran M, Hawasli AH, Snyder AZ, Hacker CD, Mitchell TJ, Shimony JS. Resting-State Blood Oxygen Level-Dependent Functional MRI: A Paradigm Shift in Preoperative Brain Mapping. Stereotactic and Functional Neurosurgery. 93: 427-439. PMID 26784290 DOI: 10.1159/000442424 |
0.01 |
|
| 2015 |
Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger GE, Cobbold M, Buckley CD, Mitchell TJ, et al. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. The Journal of Clinical Investigation. PMID 26571395 DOI: 10.1172/JCI79070 |
0.01 |
|
| 2015 |
Gonçalves MT, Mitchell TJ, Lord JM. Immune ageing and susceptibility to Streptococcus pneumoniae. Biogerontology. PMID 26472172 DOI: 10.1007/s10522-015-9614-8 |
0.01 |
|
| 2015 |
Ahn D, Wier KA, Mitchell TP, Olney PA. Applications of Fast, Facile, Radiation-Free Radical Polymerization Techniques Enabled by Room Temperature Alkylborane Chemistry. Acs Applied Materials & Interfaces. 7: 23902-11. PMID 26465352 DOI: 10.1021/acsami.5b05943 |
0.01 |
|
| 2015 |
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, et al. Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue. Plos One. 10: e0137108. PMID 26317436 DOI: 10.1371/journal.pone.0137108 |
0.01 |
|
| 2015 |
Herbert JA, Mitchell AM, Mitchell TJ. A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro. Plos One. 10: e0127212. PMID 26090876 DOI: 10.1371/journal.pone.0127212 |
0.01 |
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| 2015 |
Donati C, Glaser P, Mitchell T. Evolution and molecular epidemiology of streptococci. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 33: 333. PMID 26054562 DOI: 10.1016/j.meegid.2015.05.028 |
0.01 |
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| 2015 |
Pope C, Oliver EH, Ma J, Langton Hewer C, Mitchell TJ, Finn A. Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses. Vaccine. 33: 1711-8. PMID 25698489 DOI: 10.1016/j.vaccine.2015.02.012 |
0.01 |
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| 2015 |
Chetty P, Choi F, Mitchell T. Primary care review of actinic keratosis and its therapeutic options: a global perspective. Dermatology and Therapy. 5: 19-35. PMID 25647448 DOI: 10.1007/s13555-015-0070-9 |
0.01 |
|
| 2015 |
Anderson R, Nel J, Theron A, Mitchell T, Feldman C. S85 Pneumolysin triggers the production of platelet-activating factor by human neutrophils in vitro: Abstract S85 Table 1 Thorax. 70: A49.2-A49. DOI: 10.1136/thoraxjnl-2015-207770.91 |
0.01 |
|
| 2015 |
Cox AJ, Brueggemann AB, Mitchell T, Brown JS. Progress towards understanding the pathology of the pneumococcus Pneumonia. 7: 1-2. DOI: 10.1007/BF03371466 |
0.01 |
|
| 2014 |
Kamran M, Hacker CD, Allen MG, Mitchell TJ, Leuthardt EC, Snyder AZ, Shimony JS. Resting-state blood oxygen level-dependent functional magnetic resonance imaging for presurgical planning. Neuroimaging Clinics of North America. 24: 655-69. PMID 25441506 DOI: 10.1016/J.Nic.2014.07.009 |
0.01 |
|
| 2014 |
Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK, Dockrell DH. Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation. Mbio. 5: e01710-14. PMID 25293758 DOI: 10.1128/mBio.01710-14 |
0.01 |
|
| 2014 |
Cockeran R, Herbert JA, Mitchell TJ, Dix-Peek T, Dickens C, Anderson R, Feldman C. Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11). Biomed Research International. 2014: 976347. PMID 25013815 DOI: 10.1155/2014/976347 |
0.01 |
|
| 2014 |
Mitchell TJ, Mitchell AM. Pneumococcus adapts to the sickle cell host. Cell Host & Microbe. 15: 521-3. PMID 24832446 DOI: 10.1016/j.chom.2014.04.013 |
0.01 |
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| 2014 |
Ross EA, Flores-Langarica A, Bobat S, Coughlan RE, Marshall JL, Hitchcock JR, Cook CN, Carvalho-Gaspar MM, Mitchell AM, Clarke M, Garcia P, Cobbold M, Mitchell TJ, Henderson IR, Jones ND, et al. Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function. European Journal of Immunology. 44: 2318-30. PMID 24825601 DOI: 10.1002/eji.201344350 |
0.01 |
|
| 2014 |
Mitchell TJ, Dalziel CE. The biology of pneumolysin. Sub-Cellular Biochemistry. 80: 145-60. PMID 24798011 DOI: 10.1007/978-94-017-8881-6_8 |
0.01 |
|
| 2014 |
Mitchell T, Cheng E, Jolley J, Delaney S. Successful induction of labor of late-second-trimester conjoined twins: an alternative to hysterotomy. Obstetrics and Gynecology. 123: 469-72. PMID 24413234 DOI: 10.1097/AOG.0000000000000038 |
0.01 |
|
| 2014 |
Gray C, Ahmed MS, Mubarak A, Kasbekar AV, Derbyshire S, McCormick MS, Mughal MK, McNamara PS, Mitchell T, Zhang Q. Activation of memory Th17 cells by domain 4 pneumolysin in human nasopharynx-associated lymphoid tissue and its association with pneumococcal carriage. Mucosal Immunology. 7: 705-17. PMID 24220296 DOI: 10.1038/mi.2013.89 |
0.01 |
|
| 2014 |
Lamb KE, Flasche S, Diggle M, Inverarity D, Greenhalgh D, Jefferies JM, Smith A, Edwards GF, Denham B, McMenamin J, McDonald E, Mitchell TJ, Clarke SC, Robertson C. Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999-2010. Vaccine. 32: 4356-63. PMID 23806244 DOI: 10.1016/j.vaccine.2013.05.079 |
0.01 |
|
| 2014 |
Frampton SJ, Mitchell TE. Surgical safety issues relating to the use of diathermy in patients with cochlear implants: the patient's perspective. Cochlear Implants International. 15: 48-52. PMID 23692987 DOI: 10.1179/1754762813Y.0000000031 |
0.01 |
|
| 2013 |
Mitchell TS, Maciel JA, Janzen FJ. Does sex-ratio selection influence nest-site choice in a reptile with temperature-dependent sex determination? Proceedings. Biological Sciences / the Royal Society. 280: 20132460. PMID 24266033 |
0.01 |
|
| 2013 |
Mitchell TJ, Hacker CD, Breshears JD, Szrama NP, Sharma M, Bundy DT, Pahwa M, Corbetta M, Snyder AZ, Shimony JS, Leuthardt EC. A novel data-driven approach to preoperative mapping of functional cortex using resting-state functional magnetic resonance imaging. Neurosurgery. 73: 969-82; discussion 9. PMID 24264234 DOI: 10.1227/Neu.0000000000000141 |
0.01 |
|
| 2013 |
Croucher NJ, Mitchell AM, Gould KA, Inverarity D, Barquist L, Feltwell T, Fookes MC, Harris SR, Dordel J, Salter SJ, Browall S, Zemlickova H, Parkhill J, Normark S, Henriques-Normark B, ... ... Mitchell TJ, et al. Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. Plos Genetics. 9: e1003868. PMID 24130509 DOI: 10.1371/Journal.Pgen.1003868 |
0.01 |
|
| 2013 |
Smith A, Johnston C, Inverarity D, Slack M, Paterson GK, Diggle M, Mitchell T. Investigating the role of pneumococcal neuraminidase A activity in isolates from pneumococcal haemolytic uraemic syndrome. Journal of Medical Microbiology. 62: 1735-42. PMID 23924664 DOI: 10.1099/jmm.0.063479-0 |
0.01 |
|
| 2013 |
Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI. Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage. Plos Pathogens. 9: e1003380. PMID 23785278 DOI: 10.1371/journal.ppat.1003380 |
0.01 |
|
| 2013 |
Mitchell TS, Warner DA, Janzen FJ. Phenotypic and fitness consequences of maternal nest-site choice across multiple early life stages. Ecology. 94: 336-45. PMID 23691653 DOI: 10.1890/12-0343.1 |
0.01 |
|
| 2013 |
Proctor RD, Gawne-Cain ML, Eyles J, Mitchell TE, Batty VB. MRI during cochlear implant assessment: Should we image the whole brain? Cochlear Implants International. 14: 2-6. PMID 23340090 DOI: 10.1179/1754762811Y.0000000029 |
0.01 |
|
| 2013 |
Hupp S, Förtsch C, Wippel C, Ma J, Mitchell TJ, Iliev AI. Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin. Journal of Molecular Biology. 425: 636-46. PMID 23219469 DOI: 10.1016/j.jmb.2012.11.034 |
0.01 |
|
| 2013 |
Warner DA, Mitchell TS. Does maternal oviposition site influence offspring dispersal to suitable habitat? Oecologia. 172: 679-88. PMID 23196739 DOI: 10.1007/s00442-012-2533-3 |
0.01 |
|
| 2013 |
Arnold MF, Haag AF, Capewell S, Boshoff HI, James EK, McDonald R, Mair I, Mitchell AM, Kerscher B, Mitchell TJ, Mergaert P, Barry CE, Scocchi M, Zanda M, Campopiano DJ, et al. Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein. Journal of Bacteriology. 195: 389-98. PMID 23161027 DOI: 10.1128/JB.01445-12 |
0.01 |
|
| 2013 |
Mitchell TJ, Neil JJ, Zempel JM, Thio LL, Inder TE, Bretthorst GL. Automating the analysis of EEG recordings from prematurely-born infants: a Bayesian approach. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 124: 452-61. PMID 23014143 DOI: 10.1016/J.Clinph.2012.09.003 |
0.01 |
|
| 2013 |
Mutepe ND, Cockeran R, Steel HC, Theron AJ, Mitchell TJ, Feldman C, Anderson R. Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin. The European Respiratory Journal. 41: 392-5. PMID 22743667 DOI: 10.1183/09031936.00213211 |
0.01 |
|
| 2013 |
Ritchie N, Mitchell T, Evans T. T6 The role of IL-17A in a mouse model of pulmonary infection caused by streptococcus pneumoniae is strain dependent Thorax. 68: A3-A3. DOI: 10.1136/thoraxjnl-2013-204457.6 |
0.01 |
|
| 2013 |
Ritchie ND, Mitchell TJ, Evans TJ. Role of interleukin 17 in the innate immune response to pneumococcal infection is strain dependent Journal of Infection. 67: 342. DOI: 10.1016/J.JINF.2013.07.002 |
0.01 |
|
| 2012 |
Wiertsema SP, Corscadden KJ, Mowe EN, Zhang G, Vijayasekaran S, Coates HL, Mitchell TJ, Thomas WR, Richmond PC, Kirkham LA. IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media. Plos One. 7: e49061. PMID 23152850 DOI: 10.1371/journal.pone.0049061 |
0.01 |
|
| 2012 |
Chimalapati S, Cohen JM, Camberlein E, MacDonald N, Durmort C, Vernet T, Hermans PW, Mitchell T, Brown JS. Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo. Plos One. 7: e41393. PMID 22911788 DOI: 10.1371/journal.pone.0041393 |
0.01 |
|
| 2012 |
Dockrell DH, Whyte MK, Mitchell TJ. Pneumococcal pneumonia: mechanisms of infection and resolution. Chest. 142: 482-91. PMID 22871758 DOI: 10.1378/chest.12-0210 |
0.01 |
|
| 2012 |
Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK, Dockrell DH. Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. Plos Pathogens. 8: e1002814. PMID 22829769 DOI: 10.1371/journal.ppat.1002814 |
0.01 |
|
| 2012 |
Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li CF, et al. Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. Cell Death & Disease. 3: e342. PMID 22764101 DOI: 10.1038/cddis.2012.83 |
0.01 |
|
| 2012 |
Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, ... Mitchell TJ, et al. Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. American Journal of Respiratory Cell and Molecular Biology. 47: 445-53. PMID 22582175 DOI: 10.1165/Rcmb.2011-0332Oc |
0.01 |
|
| 2012 |
Tyrrell C, McKechnie SR, Beers MF, Mitchell TJ, McElroy MC. Differential alveolar epithelial injury and protein expression in pneumococcal pneumonia. Experimental Lung Research. 38: 266-76. PMID 22563685 DOI: 10.3109/01902148.2012.683321 |
0.01 |
|
| 2012 |
Holmes A, Lindestam Arlehamn CS, Wang D, Mitchell TJ, Evans TJ, Roe AJ. Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2. Plos One. 7: e33408. PMID 22428045 DOI: 10.1371/journal.pone.0033408 |
0.01 |
|
| 2012 |
Ritchie ND, Mitchell TJ, Evans TJ. What is different about serotype 1 pneumococci? Future Microbiology. 7: 33-46. PMID 22191445 DOI: 10.2217/fmb.11.146 |
0.01 |
|
| 2012 |
van den Biggelaar AH, Pomat WS, Phuanukoonnon S, Michael A, Aho C, Nadal-Sims MA, Devitt CJ, Jacoby PA, Hales BJ, Smith WA, Mitchell T, Wiertsema S, Richmond P, Siba P, Holt PG, et al. Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy. The Pediatric Infectious Disease Journal. 31: 243-8. PMID 22189528 DOI: 10.1097/INF.0b013e318245a5a8 |
0.01 |
|
| 2012 |
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I, Dockrell DH. Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infection and Immunity. 80: 1140-9. PMID 22158745 DOI: 10.1128/IAI.05697-11 |
0.01 |
|
| 2012 |
Lüttge M, Fulde M, Talay SR, Nerlich A, Rohde M, Preissner KT, Hammerschmidt S, Steinert M, Mitchell TJ, Chhatwal GS, Bergmann S. Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. Cellular Microbiology. 14: 210-25. PMID 21999205 DOI: 10.1111/j.1462-5822.2011.01712.x |
0.01 |
|
| 2012 |
Hupp S, Heimeroth V, Wippel C, Förtsch C, Ma J, Mitchell TJ, Iliev AI. Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema. Glia. 60: 137-46. PMID 21989652 DOI: 10.1002/glia.21256 |
0.01 |
|
| 2012 |
McKenzie RC, Jones CL, Tosi I, Caesar JA, Whittaker SJ, Mitchell TJ. Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1. Leukemia. 26: 323-31. PMID 21818116 DOI: 10.1038/leu.2011.198 |
0.01 |
|
| 2012 |
Cockeran R, Steel HC, Wolter N, Gouveia Ld, Gottberg Av, Klugman KP, Leanord AT, Inverarity DJ, Mitchell TJ, Feldman C, Anderson R. Effects of Clarithromycin at Sub-Minimum Inhibitory Concentrations on Early <i>erm</i>B Gene Expression, Metabolic Activity and Growth of an <i>erm</i>(B)-Expressing Macrolide-Resistant Strain of <i>Streptococcus pneumoniae</i> Open Journal of Respiratory Diseases. 2: 1-8. DOI: 10.4236/ojrd.2012.21001 |
0.01 |
|
| 2012 |
Cockeran R, Herbert J, Mitchell T, Steel H, Mutepe N, Feldman C, Anderson R. S107 Effects of Exposure to Cigarette Smoke Condensate on Pneumococcal Gene Expression in Relation to Biofilm Formation Thorax. 67: A52.1-A52. DOI: 10.1136/THORAXJNL-2012-202678.112 |
0.01 |
|
| 2011 |
Hiller NL, Eutsey RA, Powell E, Earl JP, Janto B, Martin DP, Dawid S, Ahmed A, Longwell MJ, Dahlgren ME, Ezzo S, Tettelin H, Daugherty SC, Mitchell TJ, Hillman TA, et al. Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. Plos One. 6: e28850. PMID 22205975 DOI: 10.1371/Journal.Pone.0028850 |
0.01 |
|
| 2011 |
Pido-Lopez J, Kwok WW, Mitchell TJ, Heyderman RS, Williams NA. Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. Plos Pathogens. 7: e1002396. PMID 22144893 DOI: 10.1371/journal.ppat.1002396 |
0.01 |
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| 2011 |
Förtsch C, Hupp S, Ma J, Mitchell TJ, Maier E, Benz R, Iliev AI. Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Toxins. 3: 43-62. PMID 22069689 DOI: 10.3390/toxins3010043 |
0.01 |
|
| 2011 |
Cockeran R, Steel HC, Theron AJ, Mitchell TJ, Feldman C, Anderson R. Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro. Vaccine. 29: 8780-2. PMID 21968446 DOI: 10.1016/j.vaccine.2011.09.080 |
0.01 |
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| 2011 |
Wippel C, Förtsch C, Hupp S, Maier E, Benz R, Ma J, Mitchell TJ, Iliev AI. Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue. The Journal of Infectious Diseases. 204: 930-6. PMID 21849290 DOI: 10.1093/infdis/jir434 |
0.01 |
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| 2011 |
Wang D, Zetterström CE, Gabrielsen M, Beckham KS, Tree JJ, Macdonald SE, Byron O, Mitchell TJ, Gally DL, Herzyk P, Mahajan A, Uvell H, Burchmore R, Smith BO, Elofsson M, et al. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. The Journal of Biological Chemistry. 286: 29922-31. PMID 21724850 DOI: 10.1074/jbc.M111.233858 |
0.01 |
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| 2011 |
Inverarity D, Diggle M, Ure R, Johnson P, Altstadt P, Mitchell T, Edwards G, Santana-Hernandez D. Molecular epidemiology and genetic diversity of pneumococcal carriage among children in Beni State, Bolivia. Transactions of the Royal Society of Tropical Medicine and Hygiene. 105: 445-51. PMID 21714978 DOI: 10.1016/j.trstmh.2011.04.013 |
0.01 |
|
| 2011 |
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, ... ... Mitchell TJ, et al. The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. Journal of Immunology (Baltimore, Md. : 1950). 187: 434-40. PMID 21646297 DOI: 10.4049/jimmunol.1003143 |
0.01 |
|
| 2011 |
Larson MR, Rajashankar KR, Crowley PJ, Kelly C, Mitchell TJ, Brady LJ, Deivanayagam C. Crystal structure of the C-terminal region of Streptococcus mutans antigen I/II and characterization of salivary agglutinin adherence domains. The Journal of Biological Chemistry. 286: 21657-66. PMID 21505225 DOI: 10.1074/Jbc.M111.231100 |
0.01 |
|
| 2011 |
Inverarity D, Lamb K, Diggle M, Robertson C, Greenhalgh D, Mitchell TJ, Smith A, Jefferies JM, Clarke SC, McMenamin J, Edwards GF. Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types. Journal of Medical Microbiology. 60: 793-802. PMID 21393453 DOI: 10.1099/jmm.0.028803-0 |
0.01 |
|
| 2011 |
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK, Dockrell DH. A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. Plos Pathogens. 7: e1001262. PMID 21298030 DOI: 10.1371/Journal.Ppat.1001262 |
0.01 |
|
| 2011 |
Lebon A, Verkaik NJ, Labout JA, de Vogel CP, Hooijkaas H, Verbrugh HA, van Wamel WJ, Jaddoe VW, Hofman A, Hermans PW, Ma J, Mitchell TJ, Moll HA, van Belkum A. Natural antibodies against several pneumococcal virulence proteins in children during the pre-pneumococcal-vaccine era: the generation R study. Infection and Immunity. 79: 1680-7. PMID 21282409 DOI: 10.1128/Iai.01379-10 |
0.01 |
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| 2011 |
Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, ... ... Mitchell TJ, et al. Rapid pneumococcal evolution in response to clinical interventions. Science (New York, N.Y.). 331: 430-4. PMID 21273480 DOI: 10.1126/Science.1198545 |
0.01 |
|
| 2011 |
Shoma S, Verkaik NJ, de Vogel CP, Hermans PW, van Selm S, Mitchell TJ, van Roosmalen M, Hossain S, Rahman M, Endtz HP, van Wamel WJ, van Belkum A. Development of a multiplexed bead-based immunoassay for the simultaneous detection of antibodies to 17 pneumococcal proteins. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 30: 521-6. PMID 21086008 DOI: 10.1007/s10096-010-1113-x |
0.01 |
|
| 2011 |
Lebon A, Verkaik NJ, de Vogel CP, Hooijkaas H, Verbrugh HA, van Wamel WJ, Jaddoe VW, Hofman A, Hermans PW, Mitchell TJ, Moll HA, van Belkum A. The inverse correlation between Staphylococcus aureus and Streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels in the Generation R Study. Clinical and Vaccine Immunology : Cvi. 18: 180-3. PMID 21084460 DOI: 10.1128/Cvi.00357-10 |
0.01 |
|
| 2011 |
Dogan S, Zhang Q, Pridmore AC, Mitchell TJ, Finn A, Murdoch C. Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4. Microbes and Infection / Institut Pasteur. 13: 65-75. PMID 20974276 DOI: 10.1016/j.micinf.2010.10.003 |
0.01 |
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| 2011 |
Rioux S, Neyt C, Di Paolo E, Turpin L, Charland N, Labbé S, Mortier MC, Mitchell TJ, Feron C, Martin D, Poolman JT. Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae. Microbiology (Reading, England). 157: 336-48. PMID 20966093 DOI: 10.1099/mic.0.042184-0 |
0.01 |
|
| 2011 |
Donati C, Hiller NL, Tettelin H, Muzzi A, Croucher NJ, Angiuoli SV, Oggioni M, Hotopp J, Hu FZ, Riley DR, Covacci A, Mitchell TJ, Bentley SD, Kilian M, Ehrlich GD, et al. Correction: Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species Genome Biology. 12: 140. DOI: 10.1186/Gb-2011-12-10-140 |
0.01 |
|
| 2011 |
Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat M, Bereswill S, van der Linden M, Tschopp J, Mitchell T, et al. Differenzial Activation of the NLRP3 Inflammasome by Pneumolysin Variants and Role of NLRP3 in Pneumococcal Pneumonia Pneumologie. 65. DOI: 10.1055/s-0031-1272062 |
0.01 |
|
| 2011 |
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Meixenberger K, Tabeling C, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat M, Bereswill S, van der Linden M, Tschopp J, ... Mitchell T, et al. The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia1 Pneumologie. 65. DOI: 10.1055/S-0030-1270363 |
0.01 |
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| 2010 |
Inverarity D, Diggle M, Ure R, Santana-Hernandez D, Altstadt P, Mitchell T, Edwards G. Simultaneous nasopharyngeal carriage of two pneumococcal multilocus sequence types with a serotype 3 phenotype. International Journal of Microbiology. 2010: 765479. PMID 21151653 DOI: 10.1155/2010/765479 |
0.01 |
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| 2010 |
Donati C, Hiller NL, Tettelin H, Muzzi A, Croucher NJ, Angiuoli SV, Oggioni M, Dunning Hotopp JC, Hu FZ, Riley DR, Covacci A, Mitchell TJ, Bentley SD, Kilian M, Ehrlich GD, et al. Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biology. 11: R107. PMID 21034474 DOI: 10.1186/Gb-2010-11-10-R107 |
0.01 |
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| 2010 |
Horsham M, Saxby H, Blake J, Isaacs NW, Mitchell TJ, Riboldi-Tunnicliffe A. Expression, purification, crystallization and preliminary X-ray crystallographic data from TktA, a transketolase from the lactic acid bacterium Lactobacillus salivarius. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 899-901. PMID 20693662 DOI: 10.1107/S1744309110012157 |
0.01 |
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| 2010 |
Cooke B, Smith A, Diggle M, Lamb K, Robertson C, Inverarity D, Jefferies J, Edwards G, Mitchell T, Clarke S, McMenamin J. Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007. Journal of Medical Microbiology. 59: 1212-8. PMID 20651042 DOI: 10.1099/jmm.0.022954-0 |
0.01 |
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| 2010 |
Banerjee A, Van Sorge NM, Sheen TR, Uchiyama S, Mitchell TJ, Doran KS. Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization. Cellular Microbiology. 12: 1576-88. PMID 20557315 DOI: 10.1111/J.1462-5822.2010.01490.X |
0.01 |
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| 2010 |
Johnston C, Hinds J, Smith A, van der Linden M, Van Eldere J, Mitchell TJ. Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group. Journal of Clinical Microbiology. 48: 2762-9. PMID 20519466 DOI: 10.1128/JCM.01746-09 |
0.01 |
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| 2010 |
Jefferies JM, Tocheva AS, Rubery H, Bennett J, Garland J, Christodoulides M, Faust SN, Smith A, Mitchell TJ, Clarke SC. Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae. Journal of Medical Microbiology. 59: 808-14. PMID 20339017 DOI: 10.1099/jmm.0.018663-0 |
0.01 |
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| 2010 |
Douce G, Ross K, Cowan G, Ma J, Mitchell TJ. Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae. Vaccine. 28: 3231-7. PMID 20188176 DOI: 10.1016/j.vaccine.2010.02.014 |
0.01 |
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| 2010 |
Mitchell AM, Mitchell TJ. Streptococcus pneumoniae: virulence factors and variation. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 16: 411-8. PMID 20132250 DOI: 10.1111/j.1469-0691.2010.03183.x |
0.01 |
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| 2010 |
Rush CM, Mitchell TJ, Garside P. A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine. 28: 1620-34. PMID 20035828 DOI: 10.1016/j.vaccine.2009.11.014 |
0.01 |
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| 2010 |
Jefferies JM, Smith AJ, Edwards GF, McMenamin J, Mitchell TJ, Clarke SC. Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. Journal of Clinical Microbiology. 48: 87-96. PMID 19923488 DOI: 10.1128/JCM.01485-09 |
0.01 |
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| 2010 |
Yuste J, Khandavilli S, Ansari N, Muttardi K, Ismail L, Hyams C, Weiser J, Mitchell T, Brown JS. The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype. Infection and Immunity. 78: 283-92. PMID 19884335 DOI: 10.1128/Iai.00541-09 |
0.01 |
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| 2010 |
Feldman C, Cockeran R, Steel H, Wolter N, Gouveia Ld, Gottberg Av, Klugman KP, Leanord A, Inverarity D, Mitchell TJ, Anderson R. Effects of Clarithromycin, at Sub-MIC Concentrations, on the Growth of Macrolide-Resistant Streptococcus pneumoniae Chest. 138: 7-8. DOI: 10.1378/Chest.9504 |
0.01 |
|
| 2010 |
Jefferies JM, Smith AJ, Edwards GFS, McMenamin J, Mitchell TJ, Clarke SC. Temporal Analysis of Invasive Pneumococcal Clones from Scotland Illustrates Fluctuations in Diversity of Serotype and Genotype in the Absence of Pneumococcal Conjugate Vaccine Journal of Clinical Microbiology. 48: 1512-1512. DOI: 10.1128/jcm.00275-10 |
0.01 |
|
| 2010 |
BROWN P, BEST DJ, BROOM NJP, CASSELS R, O'HANLON PJ, MITCHELL TJ, OSBORNE NF, WILSON JM. ChemInform Abstract: The Chemistry of Pseudomonic Acid. Part 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199749153 |
0.01 |
|
| 2010 |
DEFAUW JM, MURPHY MM, JAGDMANN GEJ, HU H, LAMPE JW, HOLLINSHEAD SP, MITCHELL TJ, CRANE HM, HEERDING JM, MENDOZA JS, DAVIS JE, DARGES JW, HUBBARD FR, HALL SE. ChemInform Abstract: Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogues That are Highly Selective for Protein Kinase C Over Protein Kinase A. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199716274 |
0.01 |
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| 2009 |
Cockeran R, Mitchell TJ, Feldman C, Anderson R. Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils. The European Respiratory Journal. 34: 1167-70. PMID 19880617 DOI: 10.1183/09031936.00007109 |
0.01 |
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| 2009 |
Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. The Journal of Experimental Medicine. 206: 1845-52. PMID 19687228 DOI: 10.1084/Jem.20090386 |
0.01 |
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| 2009 |
Mureithi MW, Finn A, Ota MO, Zhang Q, Davenport V, Mitchell TJ, Williams NA, Adegbola RA, Heyderman RS. T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. The Journal of Infectious Diseases. 200: 783-93. PMID 19642930 DOI: 10.1086/605023 |
0.01 |
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| 2009 |
Koya E, Golden SA, Harvey BK, Guez-Barber DH, Berkow A, Simmons DE, Bossert JM, Nair SG, Uejima JL, Marin MT, Mitchell TB, Farquhar D, Ghosh SC, Mattson BJ, Hope BT. Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. Nature Neuroscience. 12: 1069-73. PMID 19620976 DOI: 10.1038/Nn.2364 |
0.01 |
|
| 2009 |
Romero P, Croucher NJ, Hiller NL, Hu FZ, Ehrlich GD, Bentley SD, García E, Mitchell TJ. Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. Journal of Bacteriology. 191: 4854-62. PMID 19502408 DOI: 10.1128/Jb.01272-08 |
0.01 |
|
| 2009 |
Hughes TR, Ross KS, Cowan GJ, Sivasankar B, Harris CL, Mitchell TJ, Morgan BP. Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Molecular Immunology. 46: 1561-7. PMID 19200600 DOI: 10.1016/j.molimm.2009.01.003 |
0.01 |
|
| 2009 |
Romero P, García E, Mitchell TJ. Development of a prophage typing system and analysis of prophage carriage in Streptococcus pneumoniae. Applied and Environmental Microbiology. 75: 1642-9. PMID 19168661 DOI: 10.1128/AEM.02155-08 |
0.01 |
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| 2009 |
Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, van Laak V, Tschernig T, Mitchell TJ, Schudt C, Rosseau S, Suttorp N, Schütte H. Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Critical Care Medicine. 37: 584-90. PMID 19114892 DOI: 10.1097/CCM.0b013e3181959814 |
0.01 |
|
| 2009 |
Croucher NJ, Walker D, Romero P, Lennard N, Paterson GK, Bason NC, Mitchell AM, Quail MA, Andrew PW, Parkhill J, Bentley SD, Mitchell TJ. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. Journal of Bacteriology. 191: 1480-9. PMID 19114491 DOI: 10.1128/JB.01343-08 |
0.01 |
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| 2009 |
Iliev AI, Djannatian JR, Opazo F, Gerber J, Nau R, Mitchell TJ, Wouters FS. Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Molecular Microbiology. 71: 461-77. PMID 19040644 DOI: 10.1111/J.1365-2958.2008.06538.X |
0.01 |
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| 2008 |
Bernatoniene J, Zhang Q, Dogan S, Mitchell TJ, Paton JC, Finn A. Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases. The Journal of Infectious Diseases. 198: 1823-33. PMID 18945182 DOI: 10.1086/593177 |
0.01 |
|
| 2008 |
Marriott HM, Mitchell TJ, Dockrell DH. Pneumolysin: a double-edged sword during the host-pathogen interaction. Current Molecular Medicine. 8: 497-509. PMID 18781957 DOI: 10.2174/156652408785747924 |
0.01 |
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| 2008 |
Paterson GK, Nieminen L, Jefferies JM, Mitchell TJ. PclA, a pneumococcal collagen-like protein with selected strain distribution, contributes to adherence and invasion of host cells. Fems Microbiology Letters. 285: 170-6. PMID 18557785 DOI: 10.1111/j.1574-6968.2008.01217.x |
0.01 |
|
| 2008 |
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK, Dockrell DH. Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine. 177: 887-95. PMID 18202350 DOI: 10.1164/rccm.200707-990OC |
0.01 |
|
| 2008 |
Mattson BJ, Koya E, Simmons DE, Mitchell TB, Berkow A, Crombag HS, Hope BT. Context-specific sensitization of cocaine-induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens. The European Journal of Neuroscience. 27: 202-12. PMID 18093170 DOI: 10.1111/J.1460-9568.2007.05984.X |
0.01 |
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| 2008 |
Khandavilli S, Homer KA, Yuste J, Basavanna S, Mitchell T, Brown JS. Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence. Molecular Microbiology. 67: 541-57. PMID 18086214 DOI: 10.1111/j.1365-2958.2007.06065.x |
0.01 |
|
| 2008 |
Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Mitchell T, Schudt C, Rosseau S, Suttorp N, Schütte H. Phosphodiesterase 2 Inhibition Diminished Acute Lung Injury in Murine Pneumococcal Pneumonia Pneumologie. 62. DOI: 10.1055/S-2008-1074126 |
0.01 |
|
| 2008 |
Bewley M, Daigneault M, Mitchell T, Read R, Whyte M, Dockrell D. Pneumolysin mediates lysosomal changes following internalisation by macrophages Journal of Infection. 56: 298. DOI: 10.1016/J.JINF.2008.01.016 |
0.01 |
|
| 2007 |
Fickl H, Theron AJ, Anderson R, Mitchell TJ, Feldman C. Palladium attenuates the pro-inflammatory interactions of C5a, interleukin-8 and pneumolysin with human neutrophils. Journal of Immunotoxicology. 4: 247-52. PMID 18958735 DOI: 10.1080/15476910701385612 |
0.01 |
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| 2007 |
Goos M, Zech WD, Jaiswal MK, Balakrishnan S, Ebert S, Mitchell T, Carrì MT, Keller BU, Nau R. Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury. Bmc Infectious Diseases. 7: 131. PMID 17997855 DOI: 10.1186/1471-2334-7-131 |
0.01 |
|
| 2007 |
Anderson R, Steel HC, Cockeran R, von Gottberg A, de Gouveia L, Klugman KP, Mitchell TJ, Feldman C. Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro. The Journal of Antimicrobial Chemotherapy. 60: 1155-8. PMID 17848373 DOI: 10.1093/Jac/Dkm338 |
0.01 |
|
| 2007 |
Cowan GJ, Atkins HS, Johnson LK, Titball RW, Mitchell TJ. Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis. Vaccine. 25: 7197-205. PMID 17765365 DOI: 10.1016/j.vaccine.2007.07.040 |
0.01 |
|
| 2007 |
Spreer A, von Ruden C, Mitchell TJ, Eiffert H, Nau R. Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro. Chemotherapy. 53: 327-31. PMID 17728540 DOI: 10.1159/000107691 |
0.01 |
|
| 2007 |
Jefferies JM, Johnston CH, Kirkham LA, Cowan GJ, Ross KS, Smith A, Clarke SC, Brueggemann AB, George RC, Pichon B, Pluschke G, Pfluger V, Mitchell TJ. Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks. The Journal of Infectious Diseases. 196: 936-44. PMID 17703426 DOI: 10.1086/520091 |
0.01 |
|
| 2007 |
Lintzeris N, Mitchell TB, Bond AJ, Nestor L, Strang J. Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients. Drug and Alcohol Dependence. 91: 187-94. PMID 17624687 DOI: 10.1016/j.drugalcdep.2007.05.019 |
0.01 |
|
| 2007 |
Braun JS, Hoffmann O, Schickhaus M, Freyer D, Dagand E, Bermpohl D, Mitchell TJ, Bechmann I, Weber JR. Pneumolysin causes neuronal cell death through mitochondrial damage. Infection and Immunity. 75: 4245-54. PMID 17562768 DOI: 10.1128/IAI.00031-07 |
0.01 |
|
| 2007 |
Witzenrath M, Gutbier B, Owen JS, Schmeck B, Mitchell TJ, Mayer K, Thomas MJ, Ishii S, Rosseau S, Suttorp N, Schütte H. Role of platelet-activating factor in pneumolysin-induced acute lung injury. Critical Care Medicine. 35: 1756-62. PMID 17522574 DOI: 10.1097/01.Ccm.0000269212.84709.23 |
0.01 |
|
| 2007 |
Zhang Q, Bagrade L, Bernatoniene J, Clarke E, Paton JC, Mitchell TJ, Nunez DA, Finn A. Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. The Journal of Infectious Diseases. 195: 1194-202. PMID 17357058 DOI: 10.1086/512617 |
0.01 |
|
| 2007 |
Iliev AI, Djannatian JR, Nau R, Mitchell TJ, Wouters FS. Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proceedings of the National Academy of Sciences of the United States of America. 104: 2897-902. PMID 17301241 DOI: 10.1073/Pnas.0608213104 |
0.01 |
|
| 2007 |
Romero P, Llull D, García E, Mitchell TJ, López R, Moscoso M. Isolation and characterization of a new plasmid pSpnP1 from a multidrug-resistant clone of Streptococcus pneumoniae. Plasmid. 58: 51-60. PMID 17275906 DOI: 10.1016/j.plasmid.2006.12.006 |
0.01 |
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| 2007 |
Anderson R, Steel HC, Cockeran R, Smith AM, von Gottberg A, de Gouveia L, Brink A, Klugman KP, Mitchell TJ, Feldman C. Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. The Journal of Antimicrobial Chemotherapy. 59: 224-9. PMID 17218449 DOI: 10.1093/Jac/Dkl479 |
0.01 |
|
| 2007 |
Hendriksen WT, Silva N, Bootsma HJ, Blue CE, Paterson GK, Kerr AR, de Jong A, Kuipers OP, Hermans PW, Mitchell TJ. Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent. Journal of Bacteriology. 189: 1382-9. PMID 17085554 DOI: 10.1128/Jb.01144-06 |
0.01 |
|
| 2007 |
Jefferies J, Nieminen L, Kirkham LA, Johnston C, Smith A, Mitchell TJ. Identification of a secreted cholesterol-dependent cytolysin (mitilysin) from Streptococcus mitis. Journal of Bacteriology. 189: 627-32. PMID 17071760 DOI: 10.1128/JB.01092-06 |
0.01 |
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| 2007 |
Feldman C, Cockeran R, Jedrzejas MJ, Mitchell TJ, Anderson R. Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium International Journal of Infectious Diseases. 11: 11-15. PMID 16483814 DOI: 10.1016/j.ijid.2005.09.002 |
0.01 |
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| 2007 |
Gut H, Bumann M, Riboldi-Tunnicliffe A, Mitchell T, Isaacs N, Walsh MA. Structural studies of verified virulence factors fromS. pneumoniae Acta Crystallographica Section a Foundations of Crystallography. 63: s18-s18. DOI: 10.1107/S010876730709959X |
0.01 |
|
| 2007 |
Hughes TR, Cowan GJ, Ross KS, Mitchell TJ, Morgan BP. Characterisation of the high affinity interaction between the human complement regulator CD59 and the Staphylococcus intermedius toxin, intermedilysin Molecular Immunology. 44: 3985. DOI: 10.1016/J.MOLIMM.2007.06.198 |
0.01 |
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| 2007 |
Inverarity D, Diggle M, Edwards G, Mitchell T. An evaluation of media suitable for the transportation by air of Streptococcus pneumoniae isolates Journal of Infection. 55: e65-e66. DOI: 10.1016/J.JINF.2007.04.083 |
0.01 |
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| 2006 |
Kerr AR, Paterson GK, McCluskey J, Iannelli F, Oggioni MR, Pozzi G, Mitchell TJ. The contribution of PspC to pneumococcal virulence varies between strains and is accomplished by both complement evasion and complement-independent mechanisms. Infection and Immunity. 74: 5319-24. PMID 16926426 DOI: 10.1128/IAI.00543-06 |
0.01 |
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| 2006 |
Mitchell TB, White JM, Somogyi AA, Bochner F. Switching between methadone and morphine for maintenance treatment of opioid dependence: impact on pain sensitivity and mood status. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. 15: 311-5. PMID 16867927 DOI: 10.1080/10550490600754374 |
0.01 |
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| 2006 |
Martinez Devesa P, Mitchell TE, Scott I, Moffat DA. Malignant peripheral nerve sheath tumors of the head and neck: two cases and a review of the literature. Ear, Nose, & Throat Journal. 85: 392-6. PMID 16866118 |
0.01 |
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| 2006 |
Zhang Q, Bernatoniene J, Bagrade L, Paton JC, Mitchell TJ, Hammerschmidt S, Nunez DA, Finn A. Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infection and Immunity. 74: 4735-43. PMID 16861661 DOI: 10.1128/IAI.00165-06 |
0.01 |
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| 2006 |
Clarke SC, Jefferies JM, Smith AJ, McMenamin J, Mitchell TJ, Edwards GF. Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland. Journal of Medical Microbiology. 55: 1079-84. PMID 16849728 DOI: 10.1099/jmm.0.46550-0 |
0.01 |
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| 2006 |
Paterson NG, Riboldi-Tunnicliffe A, Mitchell TJ, Isaacs NW. Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 676-9. PMID 16820692 DOI: 10.1107/S1744309106021695 |
0.01 |
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| 2006 |
Paterson NG, Riboldi-Tunicliffe A, Mitchell TJ, Isaacs NW. Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 672-5. PMID 16820691 DOI: 10.1107/S1744309106020616 |
0.01 |
|
| 2006 |
Mitchell TJ. Streptococcus pneumoniae: infection, inflammation and disease. Advances in Experimental Medicine and Biology. 582: 111-24. PMID 16802623 DOI: 10.1007/0-387-33026-7_10 |
0.01 |
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| 2006 |
Mitchell TB, Dyer KR, Newcombe D, Somogyi AA, White JM. Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients. Addiction Biology. 11: 170-4. PMID 16800831 DOI: 10.1111/j.1369-1600.2006.00014.x |
0.01 |
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| 2006 |
Witzenrath M, Gutbier B, Hocke AC, Schmeck B, Hippenstiel S, Berger K, Mitchell TJ, de los Toyos JR, Rosseau S, Suttorp N, Schütte H. Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Critical Care Medicine. 34: 1947-54. PMID 16715037 DOI: 10.1097/01.CCM.0000220496.48295.A9 |
0.01 |
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| 2006 |
Silva NA, McCluskey J, Jefferies JM, Hinds J, Smith A, Clarke SC, Mitchell TJ, Paterson GK. Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. Infection and Immunity. 74: 3513-8. PMID 16714583 DOI: 10.1128/IAI.00079-06 |
0.01 |
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| 2006 |
Lintzeris N, Mitchell TB, Bond A, Nestor L, Strang J. Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients. Journal of Clinical Psychopharmacology. 26: 274-83. PMID 16702892 DOI: 10.1097/01.jcp.0000219050.33008.61 |
0.01 |
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| 2006 |
Clarke SC, Jefferies JM, Smith AJ, McMenamin J, Mitchell TJ, Edwards GF. Potential impact of conjugate vaccine on the incidence of invasive pneumococcal disease among children in Scotland. Journal of Clinical Microbiology. 44: 1224-8. PMID 16597842 DOI: 10.1128/JCM.44.4.1224-1228.2006 |
0.01 |
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| 2006 |
Mitchell TB, Lintzeris N, Bond A, Strang J. Feasibility and acceptability of an intranasal diamorphine spray as an alternative to injectable diamorphine for maintenance treatment. European Addiction Research. 12: 91-5. PMID 16543744 DOI: 10.1159/000090428 |
0.01 |
|
| 2006 |
Paterson GK, Blue CE, Mitchell TJ. An operon in Streptococcus pneumoniae containing a putative alkylhydroperoxidase D homologue contributes to virulence and the response to oxidative stress. Microbial Pathogenesis. 40: 152-60. PMID 16542815 DOI: 10.1016/j.micpath.2005.12.003 |
0.01 |
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| 2006 |
Paterson GK, Blue CE, Mitchell TJ. Role of two-component systems in the virulence of Streptococcus pneumoniae Journal of Medical Microbiology. 55: 355-363. PMID 16533981 DOI: 10.1099/jmm.0.46423-0 |
0.01 |
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| 2006 |
Mitchell TB, Dyer KR, Peay ER. Patient and physician characteristics in relation to clinical decision making in methadone maintenance treatment. Substance Use & Misuse. 41: 393-404. PMID 16467013 DOI: 10.1080/10826080500409043 |
0.01 |
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| 2006 |
Bogaert D, Sluijter M, Toom NL, Mitchell TJ, Goessens WHF, Clarke SC, de Groot R, Hermans PWM. Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology (Reading, England). 152: 377-385. PMID 16436426 DOI: 10.1099/MIC.0.28394-0 |
0.01 |
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| 2006 |
Smith AJ, Jefferies J, Clarke SC, Dowson C, Edwards GFS, Mitchell TJ. Distribution of epidemic antibiotic-resistant pneumococcal clones in Scottish pneumococcal isolates analysed by multilocus sequence typing. Microbiology (Reading, England). 152: 361-365. PMID 16436424 DOI: 10.1099/MIC.0.28419-0 |
0.01 |
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| 2006 |
Paterson GK, Mitchell TJ. Innate immunity and the pneumococcus. Microbiology (Reading, England). 152: 285-93. PMID 16436416 DOI: 10.1099/mic.0.28551-0 |
0.01 |
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| 2006 |
Kirkham LA, Jefferies JM, Kerr AR, Jing Y, Clarke SC, Smith A, Mitchell TJ. Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin. Journal of Clinical Microbiology. 44: 151-9. PMID 16390963 DOI: 10.1128/JCM.44.1.151-159.2006 |
0.01 |
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| 2006 |
Kirkham LA, Kerr AR, Douce GR, Paterson GK, Dilts DA, Liu DF, Mitchell TJ. Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines. Infection and Immunity. 74: 586-93. PMID 16369015 DOI: 10.1128/IAI.74.1.586-593.2006 |
0.01 |
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| 2006 |
Zhang Q, Bernatoniene J, Bagrade L, Pollard AJ, Mitchell TJ, Paton JC, Finn A. Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. European Journal of Immunology. 36: 46-57. PMID 16342325 DOI: 10.1002/eji.200535101 |
0.01 |
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| 2006 |
Schmeck B, Huber S, Moog K, Zahlten J, Hocke AC, Opitz B, Hammerschmidt S, Mitchell TJ, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L730-L737. PMID 16299055 DOI: 10.1152/ajplung.00271.2005 |
0.01 |
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| 2006 |
Rush CM, Mitchell TJ, Burke B, Garside P. Dissecting the components of the humoral immune response elicited by DNA vaccines Vaccine. 24: 776-784. PMID 16198029 DOI: 10.1016/j.vaccine.2005.08.080 |
0.01 |
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| 2006 |
Paterson GK, Mitchell TJ. The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis. Microbes and Infection / Institut Pasteur. 8: 145-53. PMID 16182588 DOI: 10.1016/j.micinf.2005.06.009 |
0.01 |
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| 2006 |
Mitchell T. Pneumococcal Vaccine for Infants and Toddlers South African Family Practice. 48: 60-63. DOI: 10.1080/20786204.2006.10873430 |
0.01 |
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| 2006 |
Schmeck B, Huber S, Moog K, Zahlten J, Hocke A, Opitz B, Hammerschmidt S, Mitchell T, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Pneumococci induced IL-8 expression in human pulmonary epithelium by TLR1 and TLR2 and Rac1 Pneumologie. 60. DOI: 10.1055/S-2006-932726 |
0.01 |
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| 2006 |
Mitchell TJ. Pneumolysin. Structure, function, and role in disease The Comprehensive Sourcebook of Bacterial Protein Toxins. 680-699. DOI: 10.1016/B978-012088445-2/50044-5 |
0.01 |
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| 2005 |
Harraghy N, Mitchell TJ. Isolation and characterization of the promoter and partial enhancer region of the porcine inter-α-trypsin inhibitor heavy chain 4 gene Clinical and Diagnostic Laboratory Immunology. 12: 1336-1339. PMID 16275952 DOI: 10.1128/CDLI.12.11.1336-1339.2005 |
0.01 |
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| 2005 |
Schröter D, Cramer W, Leemans R, Prentice IC, Araújo MB, Arnell NW, Bondeau A, Bugmann H, Carter TR, Gracia CA, de la Vega-Leinert AC, Erhard M, Ewert F, Glendining M, House JI, ... ... Mitchell TD, et al. Ecosystem service supply and vulnerability to global change in Europe. Science (New York, N.Y.). 310: 1333-7. PMID 16254151 DOI: 10.1126/science.1115233 |
0.01 |
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| 2005 |
Chen S, Paterson GK, Tong HH, Mitchell TJ, DeMaria TF. Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. Fems Microbiology Letters. 253: 151-4. PMID 16246506 DOI: 10.1016/j.femsle.2005.09.052 |
0.01 |
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| 2005 |
Riboldi-Tunnicliffe A, Isaacs NW, Mitchell TJ. 1.2 Å crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold Febs Letters. 579: 5353-5360. PMID 16194532 DOI: 10.1016/j.febslet.2005.08.066 |
0.01 |
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| 2005 |
Beurg M, Hafidi A, Skinner L, Cowan G, Hondarrague Y, Mitchell TJ, Dulon D. The mechanism of pneumolysin-induced cochlear hair cell death in the rat. The Journal of Physiology. 568: 211-27. PMID 16051626 DOI: 10.1113/Jphysiol.2005.092478 |
0.01 |
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| 2005 |
Kerr AR, Paterson GK, Riboldi-Tunnicliffe A, Mitchell TJ. Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. Infection and Immunity. 73: 4245-52. PMID 15972516 DOI: 10.1128/IAI.73.7.4245-4252.2005 |
0.01 |
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| 2005 |
Ebert S, Dietz GP, Mitchell TJ, Michel U, Bähr M, Nau R. Limited protection of TAT-Bcl-X(L) against pneumolysin-induced neuronal cell death. Neuroscience Letters. 384: 349-53. PMID 15961228 DOI: 10.1016/J.Neulet.2005.05.027 |
0.01 |
|
| 2005 |
Guiral S, Mitchell TJ, Martin B, Claverys JP. Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements. Proceedings of the National Academy of Sciences of the United States of America. 102: 8710-5. PMID 15928084 DOI: 10.1073/pnas.0500879102 |
0.01 |
|
| 2005 |
Mitchell TK, Nguyen AV, Evans GM. Heterocoagulation of chalcopyrite and pyrite minerals in flotation separation Advances in Colloid and Interface Science. 114: 227-237. PMID 15894282 DOI: 10.1016/j.cis.2004.08.009 |
0.01 |
|
| 2005 |
Kerr AR, Kirkham LA, Kadioglu A, Andrew PW, Garside P, Thompson H, Mitchell TJ. Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes and Infection / Institut Pasteur. 7: 845-52. PMID 15893495 DOI: 10.1016/j.micinf.2005.02.011 |
0.01 |
|
| 2005 |
Fickl H, Cockeran R, Steel HC, Feldman C, Cowan G, Mitchell TJ, Anderson R. Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. Clinical and Experimental Immunology. 140: 274-81. PMID 15807851 DOI: 10.1111/j.1365-2249.2005.02757.x |
0.01 |
|
| 2005 |
Paterson GK, Blue CE, Mitchell TJ. Role of interleukin-18 in experimental infections with Streptococcus pneumoniae Journal of Medical Microbiology. 54: 323-326. PMID 15770015 DOI: 10.1099/jmm.0.45873-0 |
0.01 |
|
| 2005 |
Ibrahim YM, Kerr AR, Silva NA, Mitchell TJ. Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae. Infection and Immunity. 73: 730-40. PMID 15664911 DOI: 10.1128/IAI.73.2.730-740.2005 |
0.01 |
|
| 2005 |
Ebert S, Gerber J, Bader S, Mühlhauser F, Brechtel K, Mitchell TJ, Nau R. Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. Journal of Neuroimmunology. 159: 87-96. PMID 15652406 DOI: 10.1016/j.jneuroim.2004.10.005 |
0.01 |
|
| 2005 |
Bogaert D, Veenhoven RH, Sluijter M, Wannet WJ, Rijkers GT, Mitchell TJ, Clarke SC, Goessens WH, Schilder AG, Sanders EA, de Groot R, Hermans PW. Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media. Journal of Clinical Microbiology. 43: 74-83. PMID 15634953 DOI: 10.1128/JCM.43.1.74-83.2005 |
0.01 |
|
| 2005 |
Paterson NG, Mitchell TJ, Isaacs NW. Structural studies on MsmE, a sugar binding lipoprotein, fromS. pneumoniae Acta Crystallographica Section a Foundations of Crystallography. 61: c266-c266. DOI: 10.1107/S0108767305088665 |
0.01 |
|
| 2005 |
Ebert S, Dietz G, Mitchell T, Michel U, Bähr M, Nau R. Limited protection of TAT-Bcl-XL against pneumolysin-induced neuronal cell death Aktuelle Neurologie. 32: 387. DOI: 10.1055/S-2005-919421 |
0.01 |
|
| 2004 |
Jefferies JMC, Smith A, Clarke SC, Dowson C, Mitchell TJ. Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching Journal of Clinical Microbiology. 42: 5681-5688. PMID 15583299 DOI: 10.1128/JCM.42.12.5681-5688.2004 |
0.01 |
|
| 2004 |
Mitchell TB, Dyer KR, Newcombe D, Salter A, Somogyi AA, Bochner F, White JM. Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure. British Journal of Clinical Pharmacology. 58: 609-17. PMID 15563359 DOI: 10.1111/j.1365-2125.2004.02221.x |
0.01 |
|
| 2004 |
Skinner LJ, Beurg M, Mitchell TJ, Darrouzet V, Aran JM, Dulon D. Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea. Acta Oto-Laryngologica. 124: 1000-7. PMID 15513541 DOI: 10.1080/00016480410017125 |
0.01 |
|
| 2004 |
Hirst RA, Mohammed BJ, Mitchell TJ, Andrew PW, O'Callaghan C. Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody Infection and Immunity. 72: 6694-6698. PMID 15501805 DOI: 10.1128/IAI.72.11.6694-6698.2004 |
0.01 |
|
| 2004 |
Nagamune H, Ohkura K, Sukeno A, Cowan G, Mitchell TJ, Ito W, Ohnishi O, Hattori K, Yamato M, Hirota K, Miyake Y, Maeda T, Kourai H. The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein. Microbiology and Immunology. 48: 677-92. PMID 15383705 DOI: 10.1111/j.1348-0421.2004.tb03479.x |
0.01 |
|
| 2004 |
Schmeck B, Gross R, N'Guessan PD, Hocke AC, Hammerschmidt S, Mitchell TJ, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and Immunity. 72: 4940-7. PMID 15321985 DOI: 10.1128/IAI.72.9.4940-4947.2004 |
0.01 |
|
| 2004 |
Ibrahim YM, Kerr AR, McCluskey J, Mitchell TJ. Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. Journal of Bacteriology. 186: 5258-66. PMID 15292127 DOI: 10.1128/JB.186.16.5258-5266.2004 |
0.01 |
|
| 2004 |
Mitchell TB, White JM, Somogyi AA, Bochner F. Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence. Addiction (Abingdon, England). 99: 940-5. PMID 15265090 DOI: 10.1111/j.1360-0443.2004.00764.x |
0.01 |
|
| 2004 |
Solovyova AS, Nöllmann M, Mitchell TJ, Byron O. The solution structure and oligomerization behavior of two bacterial toxins: Pneumolysin and perfringolysin O Biophysical Journal. 87: 540-552. PMID 15240487 DOI: 10.1529/biophysj.104.039974 |
0.01 |
|
| 2004 |
Cockeran R, Theron AJ, Feldman C, Mitchell TJ, Anderson R. Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils Infection and Immunity. 72: 4327-4329. PMID 15213185 DOI: 10.1128/IAI.72.7.4327-4329.2004 |
0.01 |
|
| 2004 |
Kerr AR, Adrian PV, Estevão S, de Groot R, Alloing G, Claverys JP, Mitchell TJ, Hermans PW. The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease. Infection and Immunity. 72: 3902-6. PMID 15213133 DOI: 10.1128/IAI.72.7.3902-3906.2004 |
0.01 |
|
| 2004 |
Ibrahim YM, Kerr AR, McCluskey J, Mitchell TJ. Role of HtrA in the virulence and competence of Streptococcus pneumoniae. Infection and Immunity. 72: 3584-91. PMID 15155668 DOI: 10.1128/IAI.72.6.3584-3591.2004 |
0.01 |
|
| 2004 |
Kerr AR, Wei XQ, Andrew PW, Mitchell TJ. Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae. Microbial Pathogenesis. 36: 303-10. PMID 15120156 DOI: 10.1016/j.micpath.2004.02.001 |
0.01 |
|
| 2004 |
Nöllmann M, Gilbert R, Mitchell T, Sferrazza M, Byron O. The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. Biophysical Journal. 86: 3141-51. PMID 15111427 DOI: 10.1016/S0006-3495(04)74362-3 |
0.01 |
|
| 2004 |
Riboldi-Tunnicliffe A, Trombe MC, Bent CJ, Isaacs NW, Mitchell TJ. Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae. Acta Crystallographica. Section D, Biological Crystallography. 60: 950-1. PMID 15103149 DOI: 10.1107/S0907444904005712 |
0.01 |
|
| 2004 |
Riboldi-Tunnicliffe A, Bent CJ, Isaacs NW, Mitchell TJ. Expression, purification and X-ray characterization of residues 18-230 from the pneumococcal histidine triad protein A (PhtA) from Streptococcus pneumoniae Acta Crystallographica Section D: Biological Crystallography. 60: 926-928. PMID 15103141 DOI: 10.1107/S0907444904004573 |
0.01 |
|
| 2004 |
Bent CJ, Isaacs NW, Mitchell TJ, Riboldi-Tunnicliffe A. Crystal Structure of the Response Regulator 02 Receiver Domain, the Essential YycF Two-Component System of Streptococcus pneumoniae in both Complexed and Native States Journal of Bacteriology. 186: 2872-2879. PMID 15090529 DOI: 10.1128/JB.186.9.2872-2879.2004 |
0.01 |
|
| 2004 |
Paterson GK, Mitchell TJ. The biology of Gram-positive sortase enzymes Trends in Microbiology. 12: 89-95. PMID 15036325 DOI: 10.1016/j.tim.2003.12.007 |
0.01 |
|
| 2004 |
McCluskey J, Hinds J, Husain S, Witney A, Mitchell TJ. A two-component system that controls the expression of pneumococcal surface antigen a (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae Molecular Microbiology. 51: 1661-1675. PMID 15009893 DOI: 10.1111/j.1365-2958.2003.03917.x |
0.01 |
|
| 2004 |
Bogaert D, Hermans PW, Grivea IN, Katopodis GS, Mitchell TJ, Sluijter M, De Groot R, Beratis NG, Syrogiannopoulos GA. Molecular epidemiology of penicillin-susceptible non-beta-lactam-resistant Streptococcus pneumoniae isolates from Greek children. Journal of Clinical Microbiology. 41: 5633-9. PMID 14662953 DOI: 10.1128/JCM.41.12.5633-5639.2003 |
0.01 |
|
| 2004 |
Schmeck B, Gross R, N�Guessan PD, Hocke AC, Sven Hammerschmidt S, Mitchell TJ, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae induced caspase 6-deptendent apoptosis in lung epithelium Gbm Annual Fall Meeting M�Nster 2004. 2004. DOI: 10.1240/SAV_GBM_2004_H_000605 |
0.01 |
|
| 2003 |
Mitchell TJ. The pathogenesis of streptococcal infections: from tooth decay to meningitis Nature Reviews. Microbiology. 1: 219-230. PMID 15035026 |
0.01 |
|
| 2003 |
Mitchell TB, White JM, Somogyi AA, Bochner F. Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence. Drug and Alcohol Dependence. 72: 85-94. PMID 14563546 DOI: 10.1016/S0376-8716(03)00190-X |
0.01 |
|
| 2003 |
Ali F, Lee ME, Iannelli F, Pozzi G, Mitchell TJ, Read RC, Dockrell DH. Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load. The Journal of Infectious Diseases. 188: 1119-31. PMID 14551881 DOI: 10.1086/378675 |
0.01 |
|
| 2003 |
McCool TL, Cate TR, Tuomanen EI, Adrian P, Mitchell TJ, Weiser JN. Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infection and Immunity. 71: 5724-32. PMID 14500493 DOI: 10.1128/Iai.71.10.5724-5732.2003 |
0.01 |
|
| 2003 |
Blue CE, Paterson GK, Kerr AR, Bergé M, Claverys JP, Mitchell TJ. ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract. Infection and Immunity. 71: 4925-35. PMID 12933834 DOI: 10.1128/IAI.71.9.4925-4935.2003 |
0.01 |
|
| 2003 |
Spreer A, Kerstan H, Böttcher T, Gerber J, Siemer A, Zysk G, Mitchell TJ, Eiffert H, Nau R. Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrobial Agents and Chemotherapy. 47: 2649-54. PMID 12878534 DOI: 10.1128/AAC.47.8.2649-2654.2003 |
0.01 |
|
| 2003 |
Blue CE, Mitchell TJ. Contribution of a response regulator to the virulence of Streptococcus pneumoniae is strain dependent. Infection and Immunity. 71: 4405-13. PMID 12874319 DOI: 10.1128/IAI.71.8.4405-4413.2003 |
0.01 |
|
| 2003 |
Jefferies J, Clarke SC, Diggle MA, Smith A, Dowson C, Mitchell T. Automated pneumococcal MLST using liquid-handling robotics and a capillary DNA sequencer. Molecular Biotechnology. 24: 303-8. PMID 12777696 DOI: 10.1385/MB:24:3:303 |
0.01 |
|
| 2003 |
Bent CJ, Isaacs NW, Mitchell TJ, Riboldi-Tunnicliffe A. Cloning, overexpression, purification, crystallization and preliminary diffraction analysis of the receiver domain of MicA Acta Crystallographica - Section D Biological Crystallography. 59: 758-760. PMID 12657804 DOI: 10.1107/S090744490300372X |
0.01 |
|
| 2003 |
Riboldi-Tunnicliffe A, Bent CJ, Isaacs NW, Mitchell TJ. Purification, crystallization and preliminary X-ray analysis of the Enterococcus faecalis protein EF0377 Acta Crystallographica - Section D Biological Crystallography. 59: 755-757. PMID 12657803 DOI: 10.1107/S0907444903003718 |
0.01 |
|
| 2003 |
Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW. Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. Infection and Immunity. 71: 1813-9. PMID 12654795 DOI: 10.1128/IAI.71.4.1813-1819.2003 |
0.01 |
|
| 2003 |
Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW. Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin Infection and Immunity. 71: 7239-7239. DOI: 10.1128/IAI.71.12.7239.2003 |
0.01 |
|
| 2002 |
McCluskey J, Dowson CG, Mitchell TJ. The use of microarray technology for the analysis of Streptococcus pneumoniae. Comparative and Functional Genomics. 3: 366-8. PMID 18629276 DOI: 10.1002/cfg.190 |
0.01 |
|
| 2002 |
Stringaris AK, Geisenhainer J, Bergmann F, Balshüsemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R. Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiology of Disease. 11: 355-68. PMID 12586546 DOI: 10.1006/Nbdi.2002.0561 |
0.01 |
|
| 2002 |
Patz JA, Hulme M, Rosenzweig C, Mitchell TD, Goldberg RA, Githeko AK, Lele S, McMichael AJ, Le Sueur D. Climate change: Regional warming and malaria resurgence. Nature. 420: 627-8; discussion 62. PMID 12478282 DOI: 10.1038/420627A |
0.01 |
|
| 2002 |
Rush C, Mitchell T, Garside P. Efficient priming of CD4+ and CD8+ T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. Journal of Immunology (Baltimore, Md. : 1950). 169: 4951-60. PMID 12391208 DOI: 10.4049/jimmunol.169.9.4951 |
0.01 |
|
| 2002 |
Feldman C, Anderson R, Cockeran R, Mitchell T, Cole P, Wilson R. The effects of pneumolysin and hydrogen peroxide, alone and in combination, on human ciliated epithelium in vitro. Respiratory Medicine. 96: 580-5. PMID 12195838 DOI: 10.1053/RMED.2002.1316 |
0.01 |
|
| 2002 |
Cockeran R, Durandt C, Feldman C, Mitchell TJ, Anderson R. Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro Journal of Infectious Diseases. 186: 562-565. PMID 12195386 DOI: 10.1086/341563 |
0.01 |
|
| 2002 |
Brüstle M, Beck B, Schindler T, King W, Mitchell T, Clark T. Descriptors, physical properties, and drug-likeness. Journal of Medicinal Chemistry. 45: 3345-3355. PMID 12139446 DOI: 10.1021/Jm011027B |
0.01 |
|
| 2002 |
Kadioglu A, Taylor S, Iannelli F, Pozzi G, Mitchell TJ, Andrew PW. Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. Infection and Immunity. 70: 2886-90. PMID 12010976 DOI: 10.1128/IAI.70.6.2886-2890.2002 |
0.01 |
|
| 2002 |
Kerr AR, Irvine JJ, Search JJ, Gingles NA, Kadioglu A, Andrew PW, McPheat WL, Booth CG, Mitchell TJ. Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. Infection and Immunity. 70: 1547-57. PMID 11854243 DOI: 10.1128/IAI.70.3.1547-1557.2002 |
0.01 |
|
| 2002 |
Hirst RA, Yesilkaya H, Clitheroe E, Rutman A, Dufty N, Mitchell TJ, O'Callaghan C, Andrew PW. Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infection and Immunity. 70: 1017-22. PMID 11796644 DOI: 10.1128/IAI.70.2.1017-1022.2002 |
0.01 |
|
| 2002 |
Braun JS, Sublett JE, Freyer D, Mitchell TJ, Cleveland JL, Tuomanen EI, Weber JR. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. The Journal of Clinical Investigation. 109: 19-27. PMID 11781347 DOI: 10.1172/JCI12035 |
0.01 |
|
| 2002 |
Morgan PJ, Andrew PW, Mitchell TJ. Thiol-activated cytolysins International Journal of General Systems. 31: 221-229. |
0.01 |
|
| 2001 |
Cockeran R, Steel HC, Mitchell TJ, Feldman C, Anderson R. Pneumolysin potentiates production of prostaglandin E2 and leukotriene B4 by human neutrophils Infection and Immunity. 69: 3494-3496. PMID 11292782 DOI: 10.1128/IAI.69.5.3494-3496.2001 |
0.01 |
|
| 2001 |
Sullivan JH, Mitchell TJ, Steinhoff MC. Antipneumolysin antibody titers in HIV-seropositive injection drug users before and after pneumococcal bacteremia American Journal of Respiratory and Critical Care Medicine. 163: 680-684. PMID 11254523 |
0.01 |
|
| 2001 |
Lappin DF, MacLeod CP, Kerr A, Mitchell T, Kinane DF. Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clinical and Experimental Immunology. 123: 294-300. PMID 11207661 DOI: 10.1046/j.1365-2249.2001.01448.x |
0.01 |
|
| 2001 |
Cockeran R, Theron AJ, Steel HC, Matlola NM, Mitchell TJ, Feldman C, Anderson R. Proinflammatory interactions of pneumolysin with human neutrophils. The Journal of Infectious Diseases. 183: 604-11. PMID 11170986 DOI: 10.1086/318536 |
0.01 |
|
| 2001 |
Zysk G, Schneider-Wald BK, Hwang JH, Bejo L, Kim KS, Mitchell TJ, Hakenbeck R, Heinz HP. Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infection and Immunity. 69: 845-52. PMID 11159977 DOI: 10.1128/IAI.69.2.845-852.2001 |
0.01 |
|
| 2001 |
Kadioglu A, Sharpe JA, Lazou I, Svanborg C, Ockleford C, Mitchell TJ, Andrew PW. Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. Fems Microbiology Letters. 194: 105-10. PMID 11150674 DOI: 10.1111/J.1574-6968.2001.TB09454.X |
0.01 |
|
| 2001 |
Gingles NA, Alexander JE, Kadioglu A, Andrew PW, Kerr A, Mitchell TJ, Hopes E, Denny P, Brown S, Jones HB, Little S, Booth GC, McPheat WL. Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infection and Immunity. 69: 426-34. PMID 11119534 DOI: 10.1128/IAI.69.1.426-434.2001 |
0.01 |
|
| 2000 |
Mitchell TJ. Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae Research in Microbiology. 151: 413-419. PMID 10961453 DOI: 10.1016/S0923-2508(00)00175-3 |
0.01 |
|
| 2000 |
Overweg K, Kerr A, Sluijter M, Jackson MH, Mitchell TJ, de Jong AP, de Groot R, Hermans PW. The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses. Infection and Immunity. 68: 4180-8. PMID 10858235 DOI: 10.1128/IAI.68.7.4180-4188.2000 |
0.01 |
|
| 2000 |
Hirst RA, Rutman A, Sikand K, Andrew PW, Mitchell TJ, O'Callaghan C. Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells. Pediatric Research. 47: 381-4. PMID 10709739 |
0.01 |
|
| 2000 |
Hirst RA, Sikand KS, Rutman A, Mitchell TJ, Andrew PW, O'Callaghan C. Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency. Infection and Immunity. 68: 1557-62. PMID 10678974 DOI: 10.1128/IAI.68.3.1557-1562.2000 |
0.01 |
|
| 2000 |
Gilbert RJ, Heenan RK, Timmins PA, Gingles NA, Mitchell TJ, Rowe AJ, Rossjohn J, Parker MW, Andrew PW, Byron O. Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering. Journal of Molecular Biology. 293: 1145-60. PMID 10547292 DOI: 10.1006/Jmbi.1999.3210 |
0.01 |
|
| 2000 |
Kadioglu A, Gingles NA, Grattan K, Kerr A, Mitchell TJ, Andrew PW. Host Cellular Immune Response to Pneumococcal Lung Infection in Mice Infection and Immunity. 68: 2390-2390. DOI: 10.1128/IAI.68.4.2390-2390.2000 |
0.01 |
|
| 1999 |
Mohammed BJ, Mitchell TJ, Andrew PW, Hirst RA, O'Callaghan C. The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia Microbial Pathogenesis. 27: 303-309. PMID 10547234 DOI: 10.1006/mpat.1999.0306 |
0.01 |
|
| 1999 |
Seiffert D, Mitchell TJ, Wang Z, Knabb RM, Barbera F, Reilly TM, Thoolen M. Prothrombin activation in rabbits. Thrombosis Research. 93: 101-12. PMID 10030826 DOI: 10.1016/S0049-3848(98)00153-4 |
0.01 |
|
| 1999 |
Gilbert R, Rossjohn J, Parker M, Mitchell T, Rowe A, Chen S, Jiménez J, Saibil H, Byron O, Andrew P. Structure and mechanism of the bacterial protein toxin, pneumolysin Biochemical Society Transactions. 27: A55-A55. DOI: 10.1042/Bst027A055C |
0.01 |
|
| 1998 |
Gilbert RJ, Rossjohn J, Parker MW, Tweten RK, Morgan PJ, Mitchell TJ, Errington N, Rowe AJ, Andrew PW, Byron O. Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. Journal of Molecular Biology. 284: 1223-37. PMID 9837740 DOI: 10.1006/Jmbi.1998.2258 |
0.01 |
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| 1998 |
Rossjohn J, Gilbert RJ, Crane D, Morgan PJ, Mitchell TJ, Rowe AJ, Andrew PW, Paton JC, Tweten RK, Parker MW. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. Journal of Molecular Biology. 284: 449-61. PMID 9813129 DOI: 10.1006/Jmbi.1998.2167 |
0.01 |
|
| 1998 |
Mitchell TJ, Finn A. Molecular basis of virulence Archives of Disease in Childhood. 78: 197-200. PMID 9613345 |
0.01 |
|
| 1998 |
Alexander JE, Berry AM, Paton JC, Rubins JB, Andrew PW, Mitchell TJ. Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microbial Pathogenesis. 24: 167-74. PMID 9514638 DOI: 10.1006/mpat.1997.0185 |
0.01 |
|
| 1998 |
Korchev YE, Bashford CL, Pederzolli C, Pasternak CA, Morgan PJ, Andrew PW, Mitchell TJ. A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers Biochemical Journal. 329: 571-577. PMID 9445384 DOI: 10.1042/BJ3290571 |
0.01 |
|
| 1998 |
Mitchell TJ. 4.1 Introduction Methods in Microbiology. 27: 69-71. DOI: 10.1016/S0580-9517(08)70270-8 |
0.01 |
|
| 1997 |
Mitchell TJ, Alexander JE, Morgan PJ, Andrew PW. Molecular analysis of virulence factors of Streptococcus pneumoniae. Journal of Applied Microbiology. 83: 62S-71S. PMID 28621902 DOI: 10.1046/j.1365-2672.83.s1.7.x |
0.01 |
|
| 1997 |
Winter AJ, Comis SD, Osborne MP, Tarlow MJ, Stephen J, Andrew PW, Hill J, Mitchell TJ. A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infection and Immunity. 65: 4411-8. PMID 9353013 DOI: 10.1128/iai.65.11.4411-4418.1997 |
0.01 |
|
| 1997 |
Morgan PJ, Harrison G, Freestone PP, Crane D, Rowe AJ, Mitchell TJ, Andrew PW, Gilbert RJ. Structural and functional characterisation of two proteolytic fragments of the bacterial protein toxin, pneumolysin. Febs Letters. 412: 563-7. PMID 9276467 DOI: 10.1016/S0014-5793(97)00838-7 |
0.01 |
|
| 1997 |
Brown P, Best DJ, Broom NJ, Cassels R, O'Hanlon PJ, Mitchell TJ, Osborne NF, Wilson JM. The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity. Journal of Medicinal Chemistry. 40: 2563-70. PMID 9258363 DOI: 10.1021/jm960738k |
0.01 |
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| 1997 |
Misbah SA, Griffiths H, Mitchell T, Freeland A, Haeney MR, Chapel HM. Antipolysaccharide antibodies in 450 children with otitis media. Clinical and Experimental Immunology. 109: 67-72. PMID 9218826 DOI: 10.1046/j.1365-2249.1997.4291322.x |
0.01 |
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| 1997 |
Sowdhamini R, Mitchell TJ, Andrew PW, Morgan PJ. Structural and functional analogy between pneumolysin and proaerolysin Protein Engineering. 10: 207-215. PMID 9153085 DOI: 10.1093/PROTEIN/10.3.207 |
0.01 |
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| 1997 |
Mitchell TJ, Andrew PW. Biological properties of pneumolysin Microbial Drug Resistance. 3: 19-26. PMID 9109093 |
0.01 |
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| 1997 |
Andrew PW, Mitchell TJ, Morgan PJ. Relationship of structure to function in pneumolysin Microbial Drug Resistance. 3: 11-17. PMID 9109092 |
0.01 |
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| 1997 |
Canvin JR, Paton JC, Boulnois GJ, Andrew PW, Mitchell TJ. Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin Microbial Pathogenesis. 22: 129-132. PMID 9075215 DOI: 10.1006/mpat.1996.0098 |
0.01 |
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| 1997 |
Defauw JM, Murphy MM, Jagdmann GE, Hu H, Lampe JW, Hollinshead SP, Mitchell TJ, Crane HM, Heerding JM, Mendoza JS, Davis JE, Darges JW, Hubbard FR, Hall SE. Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. Journal of Medicinal Chemistry. 39: 5215-27. PMID 8978850 DOI: 10.1021/JM960581W |
0.01 |
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| 1996 |
Rubins JB, Charboneau D, Fasching C, Berry AM, Paton JC, Alexander JE, Andrew PW, Mitchell TJ, Janoff EN. Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine. 153: 1339-46. PMID 8616564 DOI: 10.1164/Ajrccm.153.4.8616564 |
0.01 |
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| 1996 |
de los Toyos JR, Méndez FJ, Aparicio JF, Vázquez F, Del Mar García Suárez M, Fleites A, Hardisson C, Morgan PJ, Andrew PW, Mitchell TJ. Functional analysis of pneumolysin by use of monoclonal antibodies. Infection and Immunity. 64: 480-4. PMID 8550195 DOI: 10.1128/iai.64.2.480-484.1996 |
0.01 |
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| 1995 |
Rayner CF, Jackson AD, Rutman A, Dewar A, Mitchell TJ, Andrew PW, Cole PJ, Wilson R. Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa. Infection and Immunity. 63: 442-7. PMID 7822008 DOI: 10.1128/iai.63.2.442-447.1995 |
0.01 |
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| 1995 |
Rubins JB, Charboneau D, Paton JC, Mitchell TJ, Andrew PW, Janoff EN. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Journal of Clinical Investigation. 95: 142-150. PMID 7814608 DOI: 10.1172/Jci117631 |
0.01 |
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| 1995 |
Canvin JR, Marvin AP, Sivakumaran M, Paton JC, Boulnois GJ, Andrew PW, Mitchell TJ. The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. The Journal of Infectious Diseases. 172: 119-23. PMID 7797901 DOI: 10.1093/INFDIS/172.1.119 |
0.01 |
|
| 1995 |
Berry AM, Alexander JE, Mitchell TJ, Andrew PW, Hansman D, Paton JC. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infection and Immunity. 63: 1969-74. PMID 7729909 DOI: 10.1128/iai.63.5.1969-1974.1995 |
0.01 |
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| 1995 |
Morgan PJ, Hyman SC, Rowe AJ, Mitchell TJ, Andrew PW, Saibil HR. Subunit organisation and symmetry of pore-forming, oligomeric pneumolysin. Febs Letters. 371: 77-80. PMID 7664888 DOI: 10.1016/0014-5793(95)00887-F |
0.01 |
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| 1995 |
Johnson MK, Callegan MC, Engel LS, O'callaghan RJ, Hill JM, Hobden JA, Boulnois GJ, Andrew PW, Mitchell TJ. Growth and virulence of a complement-activation-negative mutant of streptococcus pneumoniae in the rabbit cornea Current Eye Research. 14: 281-284. PMID 7606914 DOI: 10.3109/02713689509033527 |
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| 1994 |
Hill J, Andrew PW, Mitchell TJ. Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis Infection and Immunity. 62: 757-758. PMID 8300240 |
0.01 |
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| 1994 |
Houldsworth S, Andrew PW, Mitchell TJ. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1β by human mononuclear phagocytes Infection and Immunity. 62: 1501-1503. PMID 8132361 |
0.01 |
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| 1994 |
Perry FE, Elson CJ, Mitchell TJ, Andrew PW, Catterall JR. Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae Thorax. 49: 676-683. PMID 8066562 DOI: 10.1136/thx.49.7.676 |
0.01 |
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| 1994 |
Rubins JB, Mitchell TJ, Andrew PW, Niewoehner DE. Pneumolysin activates phospholipase A in pulmonary artery endothelial cells Infection and Immunity. 62: 3829-3836. PMID 8063399 |
0.01 |
|
| 1994 |
Camara M, Boulnois GJ, Andrew PW, Mitchell TJ. A neuraminidase from Streptococcus pneumoniae has the features of a surface protein Infection and Immunity. 62: 3688-3695. PMID 8063384 |
0.01 |
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| 1994 |
Lee CJ, Lock RA, Andrew PW, Mitchell TJ, Hansman D, Paton JC. Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate. Vaccine. 12: 875-8. PMID 7975828 DOI: 10.1016/0264-410X(94)90028-0 |
0.01 |
|
| 1994 |
Alexander JE, Lock RA, Peeters CC, Poolman JT, Andrew PW, Mitchell TJ, Hansman D, Paton JC. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infection and Immunity. 62: 5683-8. PMID 7960154 DOI: 10.1128/iai.62.12.5683-5688.1994 |
0.01 |
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| 1994 |
Owen RHG, Boulnois GJ, Andrew PW, Mitchell TJ. A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae Fems Microbiology Letters. 121: 217-221. PMID 7926673 |
0.01 |
|
| 1994 |
Morgan PJ, Hyman SC, Byron O, Andrew PW, Mitchell TJ, Rowe AJ. Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. Journal of Biological Chemistry. 269: 25315-25320. DOI: 10.1016/s0021-9258(18)47249-3 |
0.01 |
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| 1994 |
Canvin JR, Andrew PW, Boulnois GJ, Mitchell TJ. Electrotransformation of Streptococcus pneumoniae Letters in Applied Microbiology. 18: 35-38. |
0.01 |
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| 1993 |
Comis SD, Osborne MP, Stephen J, Tarlow MJ, Hayward TL, Mitchell TJ, Andrew PW, Boulnois GJ. Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae. Acta Oto-Laryngologica. 113: 152-9. PMID 8475728 DOI: 10.3109/00016489309135784 |
0.01 |
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| 1993 |
Morgan PJ, Varley PG, Rowe AJ, Andrew PW, Mitchell TJ. Characterization of the solution properties and conformation of pneumolysin, the membrane-damaging toxin of Streptococcus pneumoniae Biochemical Journal. 296: 671-674. PMID 8280065 DOI: 10.1042/Bj2960671 |
0.01 |
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| 1993 |
Paton JC, Andrew PW, Boulnois GJ, Mitchell TJ. Molecular analysis of the pathogenicity of Streptococcus pneumoniae: The role of pneumococcal proteins Annual Review of Microbiology. 47: 89-115. PMID 7903033 |
0.01 |
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| 1993 |
Andrew PW, Mitchell TJ, Myint SH. Prevention of respiratory infections Current Opinion in Infectious Diseases. 6: 146-149. |
0.01 |
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| 1992 |
Martin B, Humbert O, Camara M, Guenzi E, Walker J, Mitchell T, Andrew P, Prudhomme M, Alloing G, Hakenbeck R, Morrison DA, Boulnois GJ, Claverys JP. A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae. Nucleic Acids Research. 20: 3479-3483. PMID 1630918 DOI: 10.1093/Nar/20.13.3479 |
0.01 |
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| 1992 |
Roberts P, Jeffery PK, Mitchell TJ, Andrew PW, Boulnois GJ, Feldman C, Cole PJ, Wilson R. Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo. Infection and Immunity. 60: 4969-72. PMID 1399007 DOI: 10.1128/iai.60.11.4969-4972.1992 |
0.01 |
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| 1992 |
Brookes SM, Pandolfino YA, Mitchell TJ, Venables PJ, Shattles WG, Clark DA, Entwistle A, Maini RN. The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease. British Journal of Rheumatology. 31: 735-42. PMID 1280512 DOI: 10.1093/RHEUMATOLOGY/31.11.735 |
0.01 |
|
| 1992 |
Mitchell T. The docking of β-lactams to streptomyces albus G β-lactamase Journal of Molecular Graphics. 10: 53. DOI: 10.1016/0263-7855(92)80033-A |
0.01 |
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| 1991 |
Feldman C, Mitchell TJ, Andrew PW, Boulnois GJ, Read RC, Todd HC, Cole PJ, Wilson R. The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro. Microbial Pathogenesis. 9: 275-84. PMID 2097494 DOI: 10.1016/0882-4010(90)90016-J |
0.01 |
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| 1991 |
Paton JC, Lock RA, Lee CJ, Li JP, Berry AM, Mitchell TJ, Andrew PW, Hansman D, Boulnois GJ. Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infection and Immunity. 59: 2297-304. PMID 2050399 DOI: 10.1128/iai.59.7.2297-2304.1991 |
0.01 |
|
| 1991 |
Camara M, Mitchell TJ, Andrew PW, Boulnois GJ. Streptococcus pneumoniae produces at least two distinct enzymes with neuroaminidase activity: Cloning and expression of a second neuraminidase gene in Escherichia coli Infection and Immunity. 59: 2856-2858. PMID 1856002 |
0.01 |
|
| 1991 |
Feldman C, Munro NC, Jeffery PK, Mitchell TJ, Andrew PW, Boulnois GJ, Guerreiro D, Rohde JA, Todd HC, Cole PJ. Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo. American Journal of Respiratory Cell and Molecular Biology. 5: 416-23. PMID 1834101 DOI: 10.1165/AJRCMB/5.5.416 |
0.01 |
|
| 1991 |
Boulnois GJ, Paton JC, Mitchell TJ, Andrew PW. Structure and function of pneumolysin, the multifunctional, thio-activated toxin of Streptococcus pneumoniae Molecular Microbiology. 5: 2611-2616. PMID 1779752 DOI: 10.1111/j.1365-2958.1991.tb01969.x |
0.01 |
|
| 1991 |
Mitchell TJ, Webb GA, Tute MS. A molecular-orbital study of the structure-activity relationships of some imidazolidines related to clonidine Journal of Molecular Structure: Theochem. 227: 327-336. DOI: 10.1016/0166-1280(91)85296-J |
0.01 |
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| 1990 |
Mitchell TJ, Mendez F, Paton JC, Andrew PW, Boulnois GJ. Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2 Nucleic Acids Research. 18: 4010. PMID 2374733 DOI: 10.1093/nar/18.13.4010 |
0.01 |
|
| 1990 |
Mitchell TJ, Tute MS, Webb GA. A theoretical study of the pKa values of some clonidine-like imidazolidines European Journal of Medicinal Chemistry. 25: 117-120. DOI: 10.1016/0223-5234(90)90018-X |
0.01 |
|
| 1989 |
Saunders FK, Mitchell TJ, Walker JA, Andrew PW, Boulnois GJ. Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity Infection and Immunity. 57: 2547-2552. PMID 2744861 |
0.01 |
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| 1989 |
Steinfort C, Wilson R, Mitchell T, Feldman C, Rutman A, Todd H, Sykes D, Walker J, Saunders K, Andrew PW. Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro. Infection and Immunity. 57: 2006-13. PMID 2731981 DOI: 10.1128/iai.57.7.2006-2013.1989 |
0.01 |
|
| 1989 |
Mitchell TJ, Walker JA, Saunders FK, Andrew PW, Boulnois GJ. Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties Bba - Gene Structure and Expression. 1007: 67-72. PMID 2642385 DOI: 10.1016/0167-4781(89)90131-0 |
0.01 |
|
| 1989 |
Mitchell TJ, Tute MS, Webb GA. A molecular modelling study of the interaction of noradrenaline with the β2-adrenergic receptor Journal of Computer-Aided Molecular Design. 3: 211-223. PMID 2555449 DOI: 10.1007/BF01533069 |
0.01 |
|
| 1989 |
Steinfort C, Wilson R, Rutman A, Sykes D, Todd H, Walker J, Mitchell T, Saunders K, Andrew P, Boulnois G, Cole P. Pneumolysin Produced by Streptococcus pneumoniae Damages Human Respiratory Epithelium in vitro Chest. 95: 221S. DOI: 10.1378/CHEST.95.3_SUPPLEMENT.221S |
0.01 |
|
| 1989 |
Mitchell TJ, Tute MS, Webb GA. A theoretical study of the influence of noradrenaline ring fluorination on its adrenergic activity Journal of Molecular Structure: Theochem. 187: 115-121. DOI: 10.1016/0166-1280(89)85154-1 |
0.01 |
|
| 1987 |
Borriello SP, Ketley JM, Mitchell TJ, Barclay FE, Welch AR, Price AB, Stephen J. Clostridium difficile--a spectrum of virulence and analysis of putative virulence determinants in the hamster model of antibiotic-associated colitis. Journal of Medical Microbiology. 24: 53-64. PMID 3612744 DOI: 10.1099/00222615-24-1-53 |
0.01 |
|
| 1987 |
Ketley JM, Mitchell TJ, Candy DC, Burdon DW, Stephen J. The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and non-immune rabbits. Journal of Medical Microbiology. 24: 41-52. PMID 3612743 |
0.01 |
|
| 1987 |
Mitchell TJ, Ketley JM, Burdon DW, Candy DC, Stephen J. Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin. Journal of Medical Microbiology. 23: 211-9. PMID 3585958 |
0.01 |
|
| 1987 |
Mitchell TJ, Ketley JM, Burdon DW, Candy DC, Stephen J. The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro. Journal of Medical Microbiology. 23: 205-10. PMID 3585957 |
0.01 |
|
| 1987 |
Reilly TM, Mitchell TJ, Flint SK, Timmermans PBMWM. A monoclonal anti-idiotypic antibody which mimics angiotensin II in inducing a population of anti-hormone antibodies Hybridoma. 6: 461-468. PMID 3500112 |
0.01 |
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| 1987 |
Mitchell TJ, Ketley JM, Burdon DW, Candy DC, Stephen J. The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers. Journal of Medical Microbiology. 23: 199-204. PMID 2856844 |
0.01 |
|
| 1986 |
Mitchell TJ, Ketley JM, Haslam SC, Stephen J, Burdon DW, Candy DC, Daniel R. Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut. 27: 78-85. PMID 3949240 DOI: 10.1136/gut.27.1.78 |
0.01 |
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| 1986 |
Ketley JM, Mitchell TJ, Haslam SC, Stephen J, Candy DC, Burdon DW. Sporogenesis and toxin A production by Clostridium difficile. Journal of Medical Microbiology. 22: 33-8. PMID 3735389 DOI: 10.1099/00222615-22-1-33 |
0.01 |
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| 1986 |
Haslam SC, Ketley JM, Mitchell TJ, Stephen J, Burdon DW, Candy DC. Growth of Clostridium difficile and production of toxins A and B in complex and defined media. Journal of Medical Microbiology. 21: 293-7. PMID 3088279 DOI: 10.1099/00222615-21-4-293 |
0.01 |
|
| 1985 |
Sunshine GH, Mitchell TJ, Czitrom AA, Edwards S, Glasebrook AL, Kelso A, MacDonald HR. Stimulator requirements for primed alloreactive T cells: macrophages and dendritic cells activate T cells across all genetic disparities. Cellular Immunology. 91: 60-74. PMID 3156000 DOI: 10.1016/0008-8749(85)90032-2 |
0.01 |
|
| 1985 |
Sunshine GH, Mitchell TJ. Antigen presentation by spleen dendritic cells Journal of Investigative Dermatology. 85. PMID 2409180 |
0.01 |
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| 1984 |
Stephen J, Redmond SC, Mitchell TJ, Ketley J, Candy DC, Burdon DW, Daniel R. Clostridium difficile enterotoxin (toxin A): new results. Biochemical Society Transactions. 12: 194-5. PMID 6724112 DOI: 10.1042/BST0120194 |
0.01 |
|
| 1984 |
Ketley JM, Haslam SC, Mitchell TJ, Stephen J, Candy DC, Burdon DW. Production and release of toxins A and B by Clostridium difficile. Journal of Medical Microbiology. 18: 385-91. PMID 6389875 DOI: 10.1099/00222615-18-3-385 |
0.01 |
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