| Year |
Citation |
Score |
| 2023 |
Hegazy R, Richard JP. Triosephosphate Isomerase: The Crippling Effect of the P168A/I172A Substitution at the Heart of an Enzyme Active Site. Biochemistry. PMID 37768194 DOI: 10.1021/acs.biochem.3c00414 |
0.373 |
|
| 2023 |
Cristobal JR, Nagorski RW, Richard JP. Utilization of Cofactor Binding Energy for Enzyme Catalysis: Formate Dehydrogenase-Catalyzed Reactions of the Whole NAD Cofactor and Cofactor Pieces. Biochemistry. PMID 37463347 DOI: 10.1021/acs.biochem.3c00290 |
0.463 |
|
| 2023 |
Cristobal JR, Richard JP. Kinetics and mechanism for enzyme-catalyzed reactions of substrate pieces. Methods in Enzymology. 685: 95-126. PMID 37245916 DOI: 10.1016/bs.mie.2023.03.002 |
0.439 |
|
| 2023 |
Hegazy R, Cordara G, Wierenga RK, Richard JP. The Role of Asn11 in Catalysis by Triosephosphate Isomerase. Biochemistry. PMID 37162263 DOI: 10.1021/acs.biochem.3c00133 |
0.356 |
|
| 2022 |
Fernandez PL, Richard JP. Adenylate Kinase-Catalyzed Reactions of AMP in Pieces: Specificity for Catalysis at the Nucleoside Activator and Dianion Catalytic Sites. Biochemistry. PMID 36413937 DOI: 10.1021/acs.biochem.2c00531 |
0.772 |
|
| 2022 |
Richard JP. Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution. Biochemistry. 61: 1533-1542. PMID 35829700 DOI: 10.1021/acs.biochem.2c00178 |
0.384 |
|
| 2022 |
Cristobal JR, Richard JP. Glycerol-3-Phosphate Dehydrogenase: The K120 and K204 Side Chains Define an Oxyanion Hole at the Enzyme Active Site. Biochemistry. PMID 35502876 DOI: 10.1021/acs.biochem.2c00053 |
0.423 |
|
| 2022 |
Pereira MS, de Araújo SS, Nagem RAP, Richard JP, Brandão TAS. The role of remote flavin adenine dinucleotide pieces in the oxidative decarboxylation catalyzed by salicylate hydroxylase. Bioorganic Chemistry. 119: 105561. PMID 34965488 DOI: 10.1016/j.bioorg.2021.105561 |
0.659 |
|
| 2021 |
Cristobal JR, Brandão TAS, Reyes AC, Richard JP. Protein-Ribofuranosyl Interactions Activate Orotidine 5'-Monophosphate Decarboxylase for Catalysis. Biochemistry. PMID 34726391 DOI: 10.1021/acs.biochem.1c00589 |
0.739 |
|
| 2021 |
Fernandez PL, Richard JP. Adenylate Kinase-Catalyzed Reaction of AMP in Pieces: Enzyme Activation for Phosphoryl Transfer to Phosphite Dianion. Biochemistry. PMID 34435776 DOI: 10.1021/acs.biochem.1c00535 |
0.761 |
|
| 2021 |
Richard JP, Cristobal JR, Amyes TL. Linear Free Energy Relationships for Enzymatic Reactions: Fresh Insight from a Venerable Probe. Accounts of Chemical Research. PMID 33939414 DOI: 10.1021/acs.accounts.1c00147 |
0.473 |
|
| 2021 |
Fernandez PL, Nagorski RW, Cristobal JR, Amyes TL, Richard JP. Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions. Journal of the American Chemical Society. PMID 33560827 DOI: 10.1021/jacs.0c13423 |
0.791 |
|
| 2020 |
He R, Cristobal JR, Gong NJ, Richard JP. Hydride Transfer Catalyzed by Glycerol Phosphate Dehydrogenase: Recruitment of an Acidic Amino Acid Side Chain to Rescue a Damaged Enzyme. Biochemistry. PMID 33305938 DOI: 10.1021/acs.biochem.0c00801 |
0.336 |
|
| 2020 |
Mhashal AR, Romero-Rivera A, Mydy LS, Cristobal JR, Gulick AM, Richard JP, Kamerlin SCL. Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase. Acs Catalysis. 10: 11253-11267. PMID 33042609 DOI: 10.1021/Acscatal.0C02757 |
0.495 |
|
| 2020 |
Brandao TAS, Richard JP. Orotidine 5'-Monophosphate Decarboxylase: The Operation of Active Site Chains Within and Across Protein Subunits. Biochemistry. PMID 32374983 DOI: 10.1021/Acs.Biochem.0C00241 |
0.432 |
|
| 2020 |
Cristobal JR, Reyes AC, Richard JP. The Organization of Active Site Side Chains at Glycerol 3-Phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes. Biochemistry. PMID 32250105 DOI: 10.1021/Acs.Biochem.0C00175 |
0.78 |
|
| 2019 |
Moreira C, Calixto AR, Richard JP, Kamerlin SCL. The role of ligand-gated conformational changes in enzyme catalysis. Biochemical Society Transactions. PMID 31657438 DOI: 10.1042/Bst20190298 |
0.428 |
|
| 2019 |
Kulkarni YS, Amyes TL, Richard J, Kamerlin SCL. Uncovering the Role of Key Active Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalysed by Wild-Type and Variants of Triosephosphate Isomerase. Journal of the American Chemical Society. PMID 31508957 DOI: 10.1021/Jacs.9B08713 |
0.512 |
|
| 2019 |
Goryanova B, Amyes TL, Richard JP. Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization. Journal of the American Chemical Society. PMID 31365243 DOI: 10.1021/Jacs.9B04823 |
0.825 |
|
| 2019 |
Richard JP. Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis. Journal of the American Chemical Society. PMID 30703322 DOI: 10.1021/Jacs.8B10836 |
0.492 |
|
| 2019 |
Mydy LS, Cristobal JR, Katigbak RD, Bauer P, Reyes AC, Kamerlin SCL, Richard JP, Gulick AM. Human Glycerol 3-Phosphate Dehydrogenase: X-Ray Crystal Structures that Guide the Interpretation of Mutagenesis Studies. Biochemistry. PMID 30640445 DOI: 10.1021/acs.biochem.8b01103 |
0.768 |
|
| 2018 |
Reyes AC, Plache DC, Koudelka AP, Amyes TL, Gerlt JA, Richard JP. Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis. Journal of the American Chemical Society. PMID 30475611 DOI: 10.1021/Jacs.8B09609 |
0.729 |
|
| 2018 |
Reyes AC, Amyes TL, Richard JP. Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase. Biochemistry. PMID 29927590 DOI: 10.1021/Acs.Biochem.8B00536 |
0.767 |
|
| 2018 |
Zhai X, Reinhardt CJ, Malabanan MM, Amyes TL, Richard JP. Enzyme Architecture: Amino Acid Side Chains Which Function to Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase. Journal of the American Chemical Society. PMID 29862813 DOI: 10.1021/Jacs.8B04367 |
0.818 |
|
| 2018 |
Richard JP, Amyes TL, Reyes AC. Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis. Accounts of Chemical Research. PMID 29595949 DOI: 10.1021/Acs.Accounts.8B00059 |
0.765 |
|
| 2018 |
Kulkarni YS, Liao Q, Byléhn F, Amyes TL, Richard JP, Kamerlin SCL. The Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase. Journal of the American Chemical Society. PMID 29516737 DOI: 10.1021/Jacs.8B00251 |
0.365 |
|
| 2018 |
He R, Reyes AC, Amyes TL, Richard J. Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-Phosphate Dehydrogenase for Catalysis of Hydride Transfer. Biochemistry. PMID 29337541 DOI: 10.1021/Acs.Biochem.7B01282 |
0.732 |
|
| 2017 |
Reyes AC, Amyes TL, Richard J. Enzyme Architecture: Erection of Active Orotidine 5'-Monophos-phate Decarboxylase by Substrate-Induced Conformational Changes. Journal of the American Chemical Society. PMID 29058891 DOI: 10.1021/Jacs.7B08897 |
0.77 |
|
| 2017 |
Amyes TL, Richard JP. Substituent Effects on Carbon Acidity in Aqueous Solution and at Enzyme Active Sites. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 28: 2407-2421. PMID 28993718 DOI: 10.1055/S-0036-1588778 |
0.348 |
|
| 2017 |
Reyes AC, Amyes TL, Richard JP. A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer. Organic & Biomolecular Chemistry. PMID 28956050 DOI: 10.1039/C7Ob01652B |
0.766 |
|
| 2017 |
Amyes TL, Richard JP. Primary Deuterium Kinetic Isotope Effects From Product Yields: Rationale, Implementation, and Interpretation. Methods in Enzymology. 596: 163-177. PMID 28911770 DOI: 10.1016/Bs.Mie.2017.06.043 |
0.395 |
|
| 2017 |
Kulkarni YS, Liao Q, Petrovic D, Krüger DM, Strodel B, Amyes TL, Richard J, Kamerlin SCL. Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase. Journal of the American Chemical Society. PMID 28683550 DOI: 10.1021/Jacs.7B05576 |
0.43 |
|
| 2016 |
Amyes TL, Malabanan MM, Zhai X, Reyes AC, Richard JP. Enzyme activation through the utilization of intrinsic dianion binding energy. Protein Engineering, Design & Selection : Peds. PMID 27903763 DOI: 10.1093/Protein/Gzw064 |
0.82 |
|
| 2016 |
Tsuji Y, Richard JP. Formation and Mechanism for Reactions of Ring-Substituted Phenonium Ions in Aqueous Solution. Journal of Physical Organic Chemistry. 29: 557-564. PMID 27812239 DOI: 10.1002/Poc.3510 |
0.327 |
|
| 2016 |
Reyes AC, Amyes TL, Richard JP. Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer. Journal of the American Chemical Society. PMID 27792325 DOI: 10.1021/Jacs.6B09936 |
0.739 |
|
| 2016 |
Reyes AC, Amyes TL, Richard JP. Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol 3-Phosphate Dehydrogenase. Journal of the American Chemical Society. PMID 27769116 DOI: 10.1021/Jacs.6B07028 |
0.7 |
|
| 2016 |
Richard JP, Amyes TL, Malabanan MM, Zhai X, Kim KJ, Reinhardt CJ, Wierenga RK, Drake EJ, Gulick AM. Structure-Function Studies on Hydrophobic Residues that Clamp a Basic Glutamate Side-Chain During Catalysis by Triosephosphate Isomerase. Biochemistry. PMID 27149328 DOI: 10.1021/Acs.Biochem.6B00311 |
0.828 |
|
| 2016 |
Reyes AC, Amyes TL, Richard JP. Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer. Biochemistry. 55: 1429-32. PMID 26926520 DOI: 10.1021/Acs.Biochem.6B00116 |
0.76 |
|
| 2016 |
Reyes AC, Amyes TL, Richard JP. Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer Biochemistry. 55: 1429-1432. DOI: 10.1021/acs.biochem.6b00116 |
0.741 |
|
| 2015 |
Tsuji Y, Richard JP. Swain-Scott Relationships for Nucleophile Addition to Ring-Substituted Phenonium Ions. Canadian Journal of Chemistry. 93: 428-434. PMID 26843657 DOI: 10.1139/Cjc-2014-0337 |
0.369 |
|
| 2015 |
Zhai X, Amyes TL, Richard JP. The Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase. Journal of the American Chemical Society. PMID 26570983 DOI: 10.1021/Jacs.5B09328 |
0.714 |
|
| 2015 |
Goryanova B, Goldman LM, Ming S, Amyes TL, Gerlt JA, Richard JP. Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase. Biochemistry. 54: 4555-64. PMID 26135041 DOI: 10.1021/Acs.Biochem.5B00591 |
0.831 |
|
| 2015 |
Reyes AC, Koudelka AP, Amyes TL, Richard JP. Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair. Journal of the American Chemical Society. 137: 5312-5. PMID 25884759 DOI: 10.1021/Jacs.5B02202 |
0.761 |
|
| 2015 |
Reyes AC, Zhai X, Morgan KT, Reinhardt CJ, Amyes TL, Richard JP. The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture. Journal of the American Chemical Society. 137: 1372-82. PMID 25555107 DOI: 10.1021/Ja5123842 |
0.824 |
|
| 2015 |
Reyes AC, Zhai X, Morgan KT, Reinhardt CJ, Amyes TL, Richard JP. The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: Specificity and enzyme architecture Journal of the American Chemical Society. 137: 1372-1382. DOI: 10.1021/ja5123842 |
0.786 |
|
| 2014 |
Richard JP. Enzyme and coenzyme reaction mechanisms: Editorial overview Bioorganic Chemistry. 57: 169-170. PMID 25465070 DOI: 10.1016/J.Bioorg.2014.11.007 |
0.45 |
|
| 2014 |
Richard JP, Zhai X, Malabanan MM. Reflections on the catalytic power of a TIM-barrel. Bioorganic Chemistry. 57: 206-12. PMID 25092608 DOI: 10.1016/J.Bioorg.2014.07.001 |
0.828 |
|
| 2014 |
Goldman LM, Amyes TL, Goryanova B, Gerlt JA, Richard JP. Enzyme architecture: Deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5′-monophosphate decarboxylase Journal of the American Chemical Society. 136: 10156-10165. PMID 24958125 DOI: 10.1021/Ja505037V |
0.84 |
|
| 2014 |
Zhai X, Go MK, O'Donoghue AC, Amyes TL, Pegan SD, Wang Y, Loria JP, Mesecar AD, Richard JP. Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501. PMID 24825099 DOI: 10.1021/Bi500458T |
0.836 |
|
| 2014 |
Zhai X, Malabanan MM, Amyes TL, Richard JP. Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion. Journal of Physical Organic Chemistry. 27: 269-276. PMID 24729658 DOI: 10.1002/Poc.3195 |
0.842 |
|
| 2014 |
Richard JP, Amyes TL, Goryanova B, Zhai X. Enzyme architecture: on the importance of being in a protein cage. Current Opinion in Chemical Biology. 21: 1-10. PMID 24699188 DOI: 10.1016/J.Cbpa.2014.03.001 |
0.817 |
|
| 2014 |
Zhai X, Amyes TL, Richard JP. Enzyme architecture: remarkably similar transition states for triosephosphate isomerase-catalyzed reactions of the whole substrate and the substrate in pieces. Journal of the American Chemical Society. 136: 4145-8. PMID 24588650 DOI: 10.1021/Ja501103B |
0.741 |
|
| 2013 |
Tsuji Y, Ogawa S, Richard JP. Substituent Effects on the Formation and Nucleophile Selectivity of Ring-Substituted Phenonium Ions in Aqueous Solution. Journal of Physical Organic Chemistry. 26: 970-976. PMID 24511183 DOI: 10.1002/Poc.3145 |
0.423 |
|
| 2013 |
Spong K, Amyes TL, Richard JP. Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase. Journal of the American Chemical Society. 135: 18343-6. PMID 24274746 DOI: 10.1021/Ja4107513 |
0.473 |
|
| 2013 |
Amyes TL, Richard JP. Concurrent stepwise and concerted substitution reactions of 4-methoxybenzyl derivatives and the lifetime of the 4-methoxybenzyl carbocation. Journal of the American Chemical Society. 112: 9507-12. PMID 24074455 DOI: 10.1021/Ja00182A009 |
0.389 |
|
| 2013 |
Goryanova B, Goldman LM, Amyes TL, Gerlt JA, Richard JP. Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5′-phosphate decarboxylase-catalyzed reactions Biochemistry. 52: 7500-7511. PMID 24053466 DOI: 10.1021/Bi401117Y |
0.842 |
|
| 2013 |
Zhai X, Amyes TL, Wierenga RK, Loria JP, Richard JP. Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase. Biochemistry. 52: 5928-40. PMID 23909928 DOI: 10.1021/Bi401019H |
0.713 |
|
| 2013 |
Malabanan MM, Nitsch-Velasquez L, Amyes TL, Richard JP. Magnitude and origin of the enhanced basicity of the catalytic glutamate of triosephosphate isomerase. Journal of the American Chemical Society. 135: 5978-81. PMID 23560625 DOI: 10.1021/Ja401504W |
0.821 |
|
| 2013 |
Amyes TL, Richard JP. Specificity in transition state binding: The pauling model revisited Biochemistry. 52: 2021-2035. PMID 23327224 DOI: 10.1021/Bi301491R |
0.544 |
|
| 2013 |
Goryanova B, Spong K, Amyes TL, Richard JP. Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates. Biochemistry. 52: 537-46. PMID 23276261 DOI: 10.1021/Bi301650D |
0.84 |
|
| 2012 |
Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational changes in orotidine 5′-monophosphate decarboxylase: A structure-based explanation for how the 5′-phosphate group activates the enzyme Biochemistry. 51: 8665-8678. PMID 23030629 DOI: 10.1021/Bi301188K |
0.822 |
|
| 2012 |
Tsang WY, Wood BM, Wong FM, Wu W, Gerlt JA, Amyes TL, Richard JP. Proton transfer from C-6 of uridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase: Formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent Journal of the American Chemical Society. 134: 14580-14594. PMID 22812629 DOI: 10.1021/Ja3058474 |
0.493 |
|
| 2012 |
Amyes TL, Ming SA, Goldman LM, Wood BM, Desai BJ, Gerlt JA, Richard JP. Orotidine 5′-monophosphate decarboxylase: Transition state stabilization from remote protein-phosphodianion interactions Biochemistry. 51: 4630-4632. PMID 22620855 DOI: 10.1021/Bi300585E |
0.498 |
|
| 2012 |
Malabanan MM, Koudelka AP, Amyes TL, Richard JP. Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a hydrophobic clamp. Journal of the American Chemical Society. 134: 10286-98. PMID 22583393 DOI: 10.1021/Ja303695U |
0.842 |
|
| 2012 |
Jonnalagadda V, Toth K, Richard JP. Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction. Journal of the American Chemical Society. 134: 6568-70. PMID 22471428 DOI: 10.1021/Ja302154K |
0.455 |
|
| 2012 |
Richard JP. A paradigm for enzyme-catalyzed proton transfer at carbon: Triosephosphate isomerase Biochemistry. 51: 2652-2661. PMID 22409228 DOI: 10.1021/Bi300195B |
0.534 |
|
| 2011 |
Toteva MM, Richard JP. The Generation and Reactions of Quinone Methides. Advances in Physical Organic Chemistry. 45: 39-91. PMID 24511169 DOI: 10.1016/B978-0-12-386047-7.00002-3 |
0.416 |
|
| 2011 |
Richard JP. Enzymatic Catalysis of Proton Transfer and Decarboxylation Reactions. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 83: 1555-1565. PMID 23505326 DOI: 10.1351/Pac-Con-11-02-05 |
0.524 |
|
| 2011 |
Tsuji Y, Hara D, Hagimoto R, Richard JP. Formation and stability of the 4-methoxyphenonium ion in aqueous solution. The Journal of Organic Chemistry. 76: 9568-71. PMID 22029847 DOI: 10.1021/Jo202118S |
0.375 |
|
| 2011 |
Toteva MM, Silvaggi NR, Allen KN, Richard JP. Binding energy and catalysis by d -xylose isomerase: Kinetic, product, and X-ray Crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde Biochemistry. 50: 10170-10181. PMID 21995300 DOI: 10.1021/Bi201378C |
0.448 |
|
| 2011 |
Malabanan MM, Amyes TL, Richard JP. Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change. Journal of the American Chemical Society. 133: 16428-31. PMID 21939233 DOI: 10.1021/Ja208019P |
0.845 |
|
| 2011 |
Malabanan MM, Go MK, Amyes TL, Richard JP. Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion. Biochemistry. 50: 5767-79. PMID 21553855 DOI: 10.1021/Bi2005416 |
0.819 |
|
| 2011 |
Goryanova B, Amyes TL, Gerlt JA, Richard JP. OMP decarboxylase: Phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate Journal of the American Chemical Society. 133: 6545-6548. PMID 21486036 DOI: 10.1021/Ja201734Z |
0.832 |
|
| 2011 |
Crugeiras J, Rios A, Riveiros E, Richard JP. Substituent effects on electrophilic catalysis by the carbonyl group: anatomy of the rate acceleration for PLP-catalyzed deprotonation of glycine. Journal of the American Chemical Society. 133: 3173-83. PMID 21323335 DOI: 10.1021/Ja110795M |
0.41 |
|
| 2011 |
Richard JP, Amyes TL, Crugeiras J, Rios A. The PLP cofactor: lessons from studies on model reactions. Biochimica Et Biophysica Acta. 1814: 1419-25. PMID 21182991 DOI: 10.1016/J.Bbapap.2010.12.007 |
0.43 |
|
| 2011 |
Richard JP. Enzymatic catalysis of proton transfer and decarboxylation reactions Pure and Applied Chemistry. 83: 1555-1565. DOI: 10.1351/PAC-CON-11-02-05 |
0.432 |
|
| 2010 |
Teshima M, Tsuji Y, Richard JP. Dynamics for Reactions of Ion Pairs in Aqueous Solution: Reactivity of Tosylate Anion Ion Paired with the Highly Destabilized 1-(4-Methylphenyl)-2,2,2-Trifluoroethyl Carbocation. Journal of Physical Organic Chemistry. 23: 730-734. PMID 21031146 DOI: 10.1002/Poc.1642 |
0.357 |
|
| 2010 |
Malabanan MM, Amyes TL, Richard JP. A role for flexible loops in enzyme catalysis. Current Opinion in Structural Biology. 20: 702-10. PMID 20951028 DOI: 10.1016/J.Sbi.2010.09.005 |
0.836 |
|
| 2010 |
Go MK, Amyes TL, Richard JP. Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces. Journal of the American Chemical Society. 132: 13525-32. PMID 20822141 DOI: 10.1021/Ja106104H |
0.804 |
|
| 2010 |
Go MK, Malabanan MM, Amyes TL, Richard JP. Bovine serum albumin-catalyzed deprotonation of [1-(13)C]glycolaldehyde: protein reactivity toward deprotonation of the alpha-hydroxy alpha-carbonyl carbon. Biochemistry. 49: 7704-8. PMID 20687575 DOI: 10.1021/Bi101118G |
0.787 |
|
| 2010 |
Go MK, Koudelka A, Amyes TL, Richard JP. Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach. Biochemistry. 49: 5377-89. PMID 20481463 DOI: 10.1021/Bi100538B |
0.817 |
|
| 2010 |
Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. Journal of the American Chemical Society. 132: 7018-24. PMID 20441167 DOI: 10.1021/Ja102408K |
0.374 |
|
| 2010 |
Wood BM, Amyes TL, Fedorov AA, Fedorov EV, Shabila A, Almo SC, Richard JP, Gerlt JA. Conformational changes in orotidine 5′-monophosphate decarboxylase: "remote" residues that stabilize the active conformation Biochemistry. 49: 3514-3516. PMID 20369850 DOI: 10.1021/Bi100443A |
0.485 |
|
| 2010 |
Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP. Activation of R235A mutant orotidine 5′-monophosphate decarboxylase by the guanidinium cation: Effective molarity of the cationic side chain of Arg-235 Biochemistry. 49: 824-826. PMID 20050635 DOI: 10.1021/Bi902174Q |
0.699 |
|
| 2009 |
Crugeiras J, Rios A, Riveiros E, Richard JP. Substituent effects on the thermodynamic stability of imines formed from glycine and aromatic aldehydes: implications for the catalytic activity of pyridoxal-5'-phosphate. Journal of the American Chemical Society. 131: 15815-24. PMID 19807092 DOI: 10.1021/Ja906230N |
0.366 |
|
| 2009 |
Tsang WY, Richard JP. Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted α-methoxystyrenes Journal of the American Chemical Society. 131: 13952-13962. PMID 19788330 DOI: 10.1021/Ja905080E |
0.424 |
|
| 2009 |
Richard JP. Punching Holes in an Enzyme Chemistry and Biology. 16: 915-917. PMID 19778716 DOI: 10.1016/J.Chembiol.2009.09.003 |
0.386 |
|
| 2009 |
Wong KY, Richard JP, Gao J. Theoretical analysis of kinetic isotope effects on proton transfer reactions between substituted alpha-methoxystyrenes and substituted acetic acids. Journal of the American Chemical Society. 131: 13963-71. PMID 19754046 DOI: 10.1021/Ja905081X |
0.422 |
|
| 2009 |
Richard JP, Amyes TL, Crugeiras J, Rios A. Pyridoxal 5'-phosphate: electrophilic catalyst extraordinaire. Current Opinion in Chemical Biology. 13: 475-83. PMID 19640775 DOI: 10.1016/J.Cbpa.2009.06.023 |
0.362 |
|
| 2009 |
Toth K, Amyes TL, Wood BM, Chan KK, Gerlt JA, Richard JP. An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Biochemistry. 48: 8006-13. PMID 19618917 DOI: 10.1021/Bi901064K |
0.505 |
|
| 2009 |
Chan KK, Wood BM, Fedorov AA, Fedorov EV, Imker HJ, Amyes TL, Richard JP, Almo SC, Gerlt JA. Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Evidence for substrate destabilization Biochemistry. 48: 5518-5531. PMID 19435314 DOI: 10.1021/Bi900623R |
0.486 |
|
| 2009 |
Wood BM, Chan KK, Amyes TL, Richard JP, Gerlt JA. Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants Biochemistry. 48: 5510-5517. PMID 19435313 DOI: 10.1021/Bi9006226 |
0.382 |
|
| 2009 |
Go MK, Amyes TL, Richard JP. Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D(2)O. Biochemistry. 48: 5769-78. PMID 19425580 DOI: 10.1021/Bi900636C |
0.776 |
|
| 2008 |
Richard JP, Heo CK, Toteva MM. Structure-Reactivity Relationships for β-Galactosidase (Escherichia coli, lac Z): A Second Derivative Effect on β(nuc) for Addition of Alkyl Alcohols to an Oxocarbenium Ion Reaction Intermediate. Journal of Physical Organic Chemistry. 21: 531-537. PMID 19684875 DOI: 10.1002/Poc.1302 |
0.368 |
|
| 2008 |
Humphry T, Iyer S, Iranzo O, Morrow JR, Richard JP, Paneth P, Hengge AC. Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst. Journal of the American Chemical Society. 130: 17858-66. PMID 19053445 DOI: 10.1021/Ja8059864 |
0.682 |
|
| 2008 |
Go MK, Richard JP. Alanine-dependent reactions of 5′-deoxypyridoxal in water Bioorganic Chemistry. 36: 295-298. PMID 18809197 DOI: 10.1016/J.Bioorg.2008.08.003 |
0.773 |
|
| 2008 |
Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP. Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5′-monophosphate decarboxylase: A two-part substrate approach Biochemistry. 47: 7785-7787. PMID 18598058 DOI: 10.1021/Bi800939K |
0.682 |
|
| 2008 |
Tsang WY, Amyes TL, Richard JP. A substrate in pieces: Allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion Biochemistry. 47: 4575-4582. PMID 18376850 DOI: 10.1021/Bi8001743 |
0.534 |
|
| 2008 |
Morrow JR, Amyes TL, Richard JP. Phosphate binding energy and catalysis by small and large molecules. Accounts of Chemical Research. 41: 539-48. PMID 18293941 DOI: 10.1021/Ar7002013 |
0.533 |
|
| 2008 |
Crugeiras J, Rios A, Riveiros E, Amyes TL, Richard JP. Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions. Journal of the American Chemical Society. 130: 2041-50. PMID 18198876 DOI: 10.1021/Ja078006C |
0.317 |
|
| 2008 |
Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Formation and stability of a vinyl carbanion at the active site of orotidine 5′-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP Journal of the American Chemical Society. 130: 1574-1575. PMID 18186641 DOI: 10.1021/Ja710384T |
0.488 |
|
| 2008 |
O'Donoghue AC, Amyes TL, Richard JP. Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O. Organic & Biomolecular Chemistry. 6: 391-6. PMID 18175010 DOI: 10.1039/B714304D |
0.452 |
|
| 2007 |
Aymes TL, Richard JP. Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications Acs Chemical Biology. 2: 711-714. PMID 18030986 DOI: 10.1021/Cb700228T |
0.429 |
|
| 2007 |
Nwe K, Richard JP, Morrow JR. Direct excitation luminescence spectroscopy of Eu(III) complexes of 1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane derivatives and kinetic studies of their catalytic cleavage of an RNA analog. Dalton Transactions (Cambridge, England : 2003). 5171-8. PMID 17985025 DOI: 10.1039/B710072H |
0.352 |
|
| 2007 |
Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. Journal of the American Chemical Society. 129: 12946-7. PMID 17918849 DOI: 10.1021/Ja076222F |
0.411 |
|
| 2007 |
Mathews RA, Rossiter CS, Morrow JR, Richard JP. A minimalist approach to understanding the efficiency of mononuclear Zn(II) complexes as catalysts of cleavage of an RNA analog. Dalton Transactions (Cambridge, England : 2003). 3804-11. PMID 17712447 DOI: 10.1039/B707409C |
0.42 |
|
| 2007 |
Tsang WY, Richard JP. A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier Journal of the American Chemical Society. 129: 10330-10331. PMID 17676848 DOI: 10.1021/Ja073679G |
0.395 |
|
| 2007 |
Farquhar ER, Richard JP, Morrow JR. Formation and stability of mononuclear and dinuclear Eu(III) complexes and their catalytic reactivity toward cleavage of an RNA analog. Inorganic Chemistry. 46: 7169-77. PMID 17655292 DOI: 10.1021/Ic7005666 |
0.407 |
|
| 2007 |
Richard JP, Williams KB. A Marcus treatment of rate constants for protonation of ring-substituted alpha-methoxystyrenes: intrinsic reaction barriers and the shape of the reaction coordinate. Journal of the American Chemical Society. 129: 6952-61. PMID 17488079 DOI: 10.1021/Ja071007K |
0.372 |
|
| 2007 |
Amyes TL, Richard JP. Enzymatic catalysis of proton transfer at carbon: Activation of triosephosphate isomerase by phosphite dianion Biochemistry. 46: 5841-5854. PMID 17444661 DOI: 10.1021/Bi700409B |
0.5 |
|
| 2007 |
Yang MY, Morrow JR, Richard JP. A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex. Bioorganic Chemistry. 35: 366-74. PMID 17434205 DOI: 10.1016/J.Bioorg.2007.02.003 |
0.437 |
|
| 2007 |
Toth K, Richard JP. Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine. Journal of the American Chemical Society. 129: 3013-21. PMID 17298067 DOI: 10.1021/Ja0679228 |
0.373 |
|
| 2007 |
Richard JP, Wolfenden RV. The ACS Division of Biological Chemistry Iubmb Life. 59: 224-225. DOI: 10.1080/15216540601187829 |
0.471 |
|
| 2006 |
Tsuji Y, Richard JP. When does an intermediate become a transition state? Degenerate isomerization without competing racemization during solvolysis of (S)-1-(3-nitrophenyl)ethyl tosylate Journal of the American Chemical Society. 128: 17139-17145. PMID 17177468 DOI: 10.1021/Ja066235D |
0.436 |
|
| 2006 |
Toth K, Gaskell LM, Richard JP. Claisen-type addition of glycine to a pyridoxal iminium ion in water. The Journal of Organic Chemistry. 71: 7094-6. PMID 16930073 DOI: 10.1021/Jo061090E |
0.319 |
|
| 2006 |
O'Donoghue A, Pyun SY, Yang MY, Morrow JR, Richard JP. Substrate specificity of an active dinuclear Zn(II) catalyst for cleavage of RNA analogues and a dinucleoside. Journal of the American Chemical Society. 128: 1615-21. PMID 16448134 DOI: 10.1021/Ja056167F |
0.468 |
|
| 2005 |
Amyes TL, Richard JP, Tait JJ. Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts. Journal of the American Chemical Society. 127: 15708-9. PMID 16277505 DOI: 10.1021/Ja055493S |
0.516 |
|
| 2005 |
Richard JP, McCall DA, Heo CK, Toteva MM. Ground-state, transition-state, and metal-cation effects of the 2-hydroxyl group on beta-D-galactopyranosyl transfer catalyzed by beta-galactosidase (Escherichia coli, lac Z). Biochemistry. 44: 11872-81. PMID 16128589 DOI: 10.1021/Bi050936Q |
0.391 |
|
| 2005 |
Tsuji Y, Richard JP. Reactions of ion-pair intermediates of solvolysis. Chemical Record (New York, N.Y.). 5: 94-106. PMID 15825158 DOI: 10.1002/Tcr.20038 |
0.429 |
|
| 2005 |
O'Donoghue AC, Amyes TL, Richard JP. Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of dihydroxyacetone phosphate in D2O. Biochemistry. 44: 2622-31. PMID 15709775 DOI: 10.1021/Bi047953K |
0.409 |
|
| 2005 |
O'Donoghue AC, Amyes TL, Richard JP. Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O. Biochemistry. 44: 2610-21. PMID 15709774 DOI: 10.1021/Bi047954C |
0.383 |
|
| 2005 |
Yang MY, Iranzo O, Richard JP, Morrow JR. Solvent deuterium isotope effects on phosphodiester cleavage catalyzed by an extraordinarily active Zn(II) complex. Journal of the American Chemical Society. 127: 1064-5. PMID 15669821 DOI: 10.1021/Ja044617I |
0.441 |
|
| 2005 |
Rios A, O'Donoghue AC, Amyes TL, Richard JP. Formation and stability of organic zwitterions The carbon acid pKas of the trimethylsulfonium and tetramethylphosphonium cations in water Canadian Journal of Chemistry. 83: 1536-1542. DOI: 10.1139/V05-155 |
0.319 |
|
| 2005 |
Richard JP, Amyes TL, Toteva MM, Tsuji Y. Dynamics for the Reactions of Ion Pair Intermediates of Solvolysis Cheminform. 36. DOI: 10.1016/S0065-3160(04)39001-5 |
0.423 |
|
| 2004 |
Tsuji Y, Toteva MM, Amyes TL, Richard JP. Scrambling of oxygen-18 during the "borderline" solvolysis of 1-(3-nitrophenyl)ethyl tosylate. Organic Letters. 6: 3633-6. PMID 15387566 DOI: 10.1021/Ol0484409 |
0.326 |
|
| 2004 |
Richard JP, Amyes TL. On the importance of being zwitterionic: Enzymatic catalysis of decarboxylation and deprotonation of cationic carbon Bioorganic Chemistry. 32: 354-366. PMID 15381401 DOI: 10.1016/J.Bioorg.2004.05.002 |
0.479 |
|
| 2004 |
Toth K, Amyes TL, Richard JP, Malthouse JP, NíBeilliú ME. Claisen-type addition of glycine to pyridoxal in water. Journal of the American Chemical Society. 126: 10538-9. PMID 15327301 DOI: 10.1021/Ja047501V |
0.353 |
|
| 2004 |
Crugeiras J, Richard JP. A Comparison of the Electrophilic Reactivities of Zn2+ and Acetic Acid as Catalysts of Enolization: Imperatives for Enzymatic Catalysis of Proton Transfer at Carbon Journal of the American Chemical Society. 126: 5164-5173. PMID 15099099 DOI: 10.1021/Ja049489C |
0.371 |
|
| 2004 |
Amyes TL, Diver ST, Richard JP, Rivas FM, Toth K. Formation and stability of N-heterocyclic carbenes in water: the carbon acid pKa of imidazolium cations in aqueous solution. Journal of the American Chemical Society. 126: 4366-74. PMID 15053626 DOI: 10.1021/Ja039890J |
0.399 |
|
| 2003 |
Tsuji Y, Toteva MM, Garth HA, Richard JP. Kinetic and thermodynamic barriers to carbon and oxygen alkylation of phenol and phenoxide ion by the 1-(4-methoxyphenyl)ethyl carbocation. Journal of the American Chemical Society. 125: 15455-65. PMID 14664591 DOI: 10.1021/Ja037328N |
0.375 |
|
| 2003 |
Yang MY, Richard JP, Morrow JR. Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex. Chemical Communications (Cambridge, England). 2832-3. PMID 14651127 DOI: 10.1039/B308644E |
0.353 |
|
| 2003 |
Iranzo O, Elmer T, Richard JP, Morrow JR. Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts. Inorganic Chemistry. 42: 7737-46. PMID 14632489 DOI: 10.1021/Ic030131B |
0.33 |
|
| 2003 |
Toteva MM, Moran M, Amyes TL, Richard JP. Substituent effects on carbocation stability: the pK(R) for p-quinone methide. Journal of the American Chemical Society. 125: 8814-9. PMID 12862476 DOI: 10.1021/Ja029588V |
0.345 |
|
| 2003 |
Williams G, Maziarz EP, Amyes TL, Wood TD, Richard JP. Formation and stability of the enolates of N-protonated proline methyl ester and proline zwitterion in aqueous solution: a nonenzymatic model for the first step in the racemization of proline catalyzed by proline racemase. Biochemistry. 42: 8354-61. PMID 12846584 DOI: 10.1021/Bi0345992 |
0.474 |
|
| 2003 |
Iranzo O, Kovalevsky AY, Morrow JR, Richard JP. Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex. Journal of the American Chemical Society. 125: 1988-93. PMID 12580627 DOI: 10.1021/Ja027728V |
0.387 |
|
| 2003 |
Tsuji Y, Mori T, Toteva MM, Richard JP. Dynamics of reaction of ion pairs in aqueous solution: racemization of the chiral ion pair intermediate of solvolysis of (S)-1-(4-methylphenyl)ethylpentafluorobenzoate Journal of Physical Organic Chemistry. 16: 484-490. DOI: 10.1002/Poc.611 |
0.331 |
|
| 2002 |
Toteva MM, Richard JP. Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride Journal of the American Chemical Society. 124: 9798-9805. PMID 12175239 DOI: 10.1021/Ja026849S |
0.351 |
|
| 2002 |
Richard JP, Williams G, O'Donoghue AC, Amyes TL. Formation and stability of enolates of acetamide and acetate anion: an Eigen plot for proton transfer at alpha-carbonyl carbon. Journal of the American Chemical Society. 124: 2957-68. PMID 11902887 DOI: 10.1021/Ja0125321 |
0.376 |
|
| 2002 |
Richard JP, Amyes TL, Toteva MM. Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions. Accounts of Chemical Research. 34: 981-8. PMID 11747416 DOI: 10.1021/Ar0000556 |
0.383 |
|
| 2002 |
Amyes TL, O'Donoghue AC, Richard JP. Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase. Journal of the American Chemical Society. 123: 11325-6. PMID 11697989 DOI: 10.1021/Ja016754A |
0.463 |
|
| 2001 |
Richard JP, Amyes TL. Proton transfer at carbon Current Opinion in Chemical Biology. 5: 626-633. PMID 11738171 DOI: 10.1016/S1367-5931(01)00258-7 |
0.491 |
|
| 2001 |
Nagorski RW, Richard JP. Mechanistic imperatives for aldose - Ketose isomerization in water: Specific, general base- and metal ion-catalyzed isomerization of glyceraldehyde with proton and hydride transfer Journal of the American Chemical Society. 123: 794-802. PMID 11456612 DOI: 10.1021/Ja003433A |
0.436 |
|
| 2001 |
Richard JP, Toteva MM, Amyes TL. What is the stabilizing interaction with nucleophilic solvents in the transition state for solvolysis of tertiary derivatives: nucleophilic solvent participation or nucleophilic solvation? Organic Letters. 3: 2225-8. PMID 11440585 DOI: 10.1021/Ol016103J |
0.386 |
|
| 2001 |
Richard JP, Huber RE, McCall DA. Effect of an E461G mutation of beta-galactosidase (Escherichia coli, lac Z) on pL rate profiles and solvent deuterium isotope effects. Bioorganic Chemistry. 29: 146-55. PMID 11437390 DOI: 10.1006/Bioo.2001.1206 |
0.387 |
|
| 2001 |
Tsuji Y, Mori T, Richard JP, Amyes TL, Fujio M, Tsuno Y. Dynamics for reaction of an ion pair in aqueous solution: Reactivity of carboxylate anions in bimolecular carbocation-nucleophile addition and unimolecular ion pair collapse Organic Letters. 3: 1237-1240. PMID 11348203 DOI: 10.1021/Ol015706S |
0.327 |
|
| 2001 |
Toteva MM, Richard JP. Deprotonation of the α-(N,N-dimethylcarbamoyl)-α-methyl-4-methoxybenzyl carbocation by alkanecarboxylate and halide ions Journal of the Chemical Society-Perkin Transactions 1. 1167-1173. DOI: 10.1039/B100296L |
0.307 |
|
| 2000 |
Richard JP, Toteva MM, Crugeiras J. Structure−Reactivity Relationships and Intrinsic Reaction Barriers for Nucleophile Additions to a Quinone Methide: A Strongly Resonance-Stabilized Carbocation Journal of the American Chemical Society. 122: 1664-1674. DOI: 10.1021/Ja9937526 |
0.358 |
|
| 2000 |
Toteva MM, Richard JP. Structure-reactivity relationships for addition of sulfur nucleophiles to electrophilic carbon: Resonance, polarization, and steric/electrostatic effects Journal of the American Chemical Society. 122: 11073-11083. DOI: 10.1021/Ja0021868 |
0.429 |
|
| 2000 |
Richard JP, Lamyes T, Lin S, O'donoghue AC, Toteva MM, Tsuji Y, Williams KB. How does structure determine organic reactivity? Partitioning of carbocations between addition of nucleophiles and deprotonation Advances in Physical Organic Chemistry. 35: 67-115. DOI: 10.1016/S0065-3160(00)35012-2 |
0.39 |
|
| 2000 |
Richard JP, McCall DA. Solvent deuterium isotope effect on the binding of β-D-galactopyranosyl derivatives to β-galactosidase (Escherichia coli, lac Z) Bioorganic Chemistry. 28: 49-56. DOI: 10.1006/Bioo.1999.1157 |
0.327 |
|
| 1999 |
Amyes TL, Mizerski T, Richard JP. How does organic structure determine organic reactivity? The effect of ortho-dimethyl groups on the nucleophilic substitution and alkene-forming elimination reactions of ring-substituted cumyl derivatives Canadian Journal of Chemistry. 77: 922-933. DOI: 10.1139/V99-084 |
0.412 |
|
| 1999 |
Richard JP, Williams KB, Amyes TL. Intrinsic Barriers for the Reactions of an Oxocarbenium Ion in Water Journal of the American Chemical Society. 121: 8403-8404. DOI: 10.1021/Ja9915293 |
0.309 |
|
| 1999 |
Richard JP, Nagorski RW. Mechanistic imperatives for catalysis of aldol addition reactions: Partitioning of the enolate intermediate between reaction with bronsted acids and the carbonyl group Journal of the American Chemical Society. 121: 4763-4770. DOI: 10.1021/Ja9900297 |
0.458 |
|
| 1999 |
Richard JP, Williams G, Gao J. Experimental and computational determination of the effect of the cyano group on carbon acidity in water Journal of the American Chemical Society. 121: 715-726. DOI: 10.1021/Ja982692L |
0.332 |
|
| 1998 |
Richard JP, Amyes TL, Williams KB. Intrinsic barriers to the formation and reaction of carbocations Pure and Applied Chemistry. 70: 2007-2014. DOI: 10.1351/Pac199870102007 |
0.421 |
|
| 1998 |
McClelland RA, Licence VE, Richard JP, Williams KB, Lin S. Remarkable kinetic stability of α-thiocarbamoyl substituted 4-methoxybenzylcations Canadian Journal of Chemistry. 76: 1910-1915. DOI: 10.1139/V98-225 |
0.318 |
|
| 1998 |
Richard JP, Szymanski P, Williams KB. Solvent effects on carbocation - Nucleophile combination reactions: A comparison of π-nucleophilicity in aqueous and organic solvents Journal of the American Chemical Society. 120: 10372-10378. DOI: 10.1021/Ja981842P |
0.346 |
|
| 1998 |
Richard JP, Crugeiras J, Nagorski RW. Imperatives for enzymatic catalysis of isomerization of sugars and sugar phosphates Journal of Physical Organic Chemistry. 11: 512-518. DOI: 10.1002/(Sici)1099-1395(199808/09)11:8/9<512::Aid-Poc54>3.0.Co;2-G |
0.421 |
|
| 1997 |
Toteva MM, Richard JP. Mechanistic imperatives for the reaction catalyzed by isopentenyl pyrophosphate isomerase: Free energy profile for stepwise isomerization in water through a tertiary carbocation intermediate Bioorganic Chemistry. 25: 239-245. DOI: 10.1006/Bioo.1997.1069 |
0.448 |
|
| 1996 |
Richard JP, Huber RE, Heo C, Amyes TL, Lin S. Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 4. Mechanism for reaction of nucleophiles with the galactosyl-enzyme intermediates of E461G and E461Q beta-galactosidases. Biochemistry. 35: 12387-401. PMID 8823174 DOI: 10.1021/Bi961029B |
0.482 |
|
| 1996 |
Richard JP, Huber RE, Lin S, Heo C, Amyes TL. Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 3. Evidence that Glu-461 participates in Brønsted acid-base catalysis of beta-D-galactopyranosyl group transfer. Biochemistry. 35: 12377-86. PMID 8823173 DOI: 10.1021/Bi961028J |
0.431 |
|
| 1996 |
Toteva MM, Richard JP. Mechanism for nucleophilic substitution and elimination reactions at tertiary carbon in largely aqueous solutions: Lifetime of a simple tertiary carbocation Journal of the American Chemical Society. 118: 11434-11445. DOI: 10.1021/Ja9617451 |
0.413 |
|
| 1996 |
Nagorski RW, Richard JP. Mechanistic imperatives for enzymatic catalysis of aldose-ketose isomerization: Isomerization of glyceraldehyde in weakly alkaline aqueous solution occurs with intramolecular transfer of a hydride ion Journal of the American Chemical Society. 118: 7432-7433. DOI: 10.1021/Ja961259D |
0.306 |
|
| 1996 |
Amyes TL, Richard JP. Determination of the pK(a) of ethyl acetate: Bronsted correlation for deprotonation of a simple oxygen ester in aqueous solution Journal of the American Chemical Society. 118: 3129-3141. DOI: 10.1021/Ja953664V |
0.368 |
|
| 1995 |
Richard JP, Westerfeld JG, Lin S, Beard J. Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 2. Reactions of the galactosyl-enzyme intermediate with alcohols and azide ion. Biochemistry. 34: 11713-24. PMID 7547903 DOI: 10.1021/Bi00037A008 |
0.388 |
|
| 1995 |
Richard JP, Westerfeld JG, Lin S. Structure-reactivity relationships for β-galactosidase (escherichia coli, lac Z), l. Brønsted parameters for cleavage of alkyl β-D-galactopyranosides Biochemistry. 34: 11703-11712. PMID 7547902 DOI: 10.1021/Bi00037A007 |
0.492 |
|
| 1995 |
Richard JP. A consideration of the barrier for carbocation-nucleophile combination reactions Tetrahedron. 51: 1535-1573. DOI: 10.1016/0040-4020(94)01019-V |
0.34 |
|
| 1994 |
Richard JP, Amyes TL, Lee Y, Jagannadham V. Demonstration of the Chemical Competence of an Iminodiazonium Ion to Serve as the Reactive Intermediate of a Schmidt Reaction Journal of the American Chemical Society. 116: 10833-10834. DOI: 10.1021/Ja00102A078 |
0.342 |
|
| 1993 |
Richard JP. Mechanism for the formation of methylglyoxal from triosephosphates Biochemical Society Transactions. 21: 549-553. PMID 8359530 DOI: 10.1042/Bst0210549 |
0.379 |
|
| 1993 |
McClelland RA, Cozens FL, Steenken S, Amyes TL, Richard JP. Direct observation of β-fluoro-substituted 4-methoxyphenethyl cations by laser flash photolysis Journal of the Chemical Society-Perkin Transactions 1. 1717-1722. DOI: 10.1039/P29930001717 |
0.343 |
|
| 1993 |
Jagannadham V, Amyes TL, Richard JP. How delocalised are resonance-stabilised 1-[4-(N-methyl-N-alkylamino)phenyl]-2,2,2-trifluoroethyl carbocations? Journal of the Chemical Society-Perkin Transactions 1. 171-174. DOI: 10.1039/P29930000171 |
0.33 |
|
| 1993 |
Amyes TL, Stevens IW, Richard JP. The effects of .alpha.-substituents on the kinetic and thermodynamic stability of 4-methoxybenzyl carbocations: carbocation lifetimes that are independent of their thermodynamic stability The Journal of Organic Chemistry. 58: 6057-6066. DOI: 10.1021/Jo00074A036 |
0.317 |
|
| 1993 |
Richard JP, Yeary PE. On the importance of carbocation intermediates in bimolecular nucleophilic substitution reactions in aqueous solution Journal of the American Chemical Society. 115: 1739-1744. DOI: 10.1021/Ja00058A019 |
0.392 |
|
| 1992 |
Amyes TL, Richard JP. Generation and stability of a simple thiol ester enolate in aqueous solution Journal of the American Chemical Society. 114: 10297-10302. DOI: 10.1021/Ja00052A028 |
0.309 |
|
| 1992 |
Amyes TL, Richard JP, Novak M. Experiments and calculations for determination of the stabilities of benzyl, benzhydryl, and fluorenyl carbocations: antiaromaticity revisited Journal of the American Chemical Society. 114: 8032-8041. DOI: 10.1021/Ja00047A010 |
0.352 |
|
| 1992 |
Richard JP, Amyes TL, Vontor T. Reactions of ring-substituted 1-phenyl-2,2,2-trifluoroethyl carbocations with nucleophilic reagents: a bridge between carbocations which follow the reactivity-selectivity principle and the N+ scale Journal of the American Chemical Society. 114: 5626-5634. DOI: 10.1021/Ja00040A023 |
0.358 |
|
| 1991 |
Richard JP. Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significance Biochemistry. 30: 4581-4585. PMID 2021650 DOI: 10.1021/Bi00232A031 |
0.524 |
|
| 1991 |
Amyes TL, Richard JP. Carbocation lifetimes that are independent of carbocation stability: The reaction of α-substituted 4-methoxybenzyl carbocations Journal of the Chemical Society, Chemical Communications. 200-202. DOI: 10.1039/C39910000200 |
0.301 |
|
| 1991 |
Amyes TL, Richard JP. How do reaction mechanisms change? Appearance of concerted pericyclic elimination for the reaction of cumyl derivatives Journal of the American Chemical Society. 113: 8960-8961. DOI: 10.1021/Ja00023A062 |
0.382 |
|
| 1991 |
Richard JP, Amyes TL, Vontor T. Absence of nucleophilic assistance by solvent and azide ion to the reaction of cumyl derivatives: mechanism of nucleophilic substitution at tertiary carbon Journal of the American Chemical Society. 113: 5871-5873. DOI: 10.1021/Ja00015A056 |
0.362 |
|
| 1991 |
Richard JP. Mechanisms for the uncatalyzed and hydrogen ion catalyzed reactions of a simple quinone methide with solvent and halide ions Journal of the American Chemical Society. 113: 4588-4595. DOI: 10.1021/Ja00012A031 |
0.357 |
|
| 1991 |
Amyes TL, Richard JP. Kinetic and thermodynamic stability of .alpha.-azidobenzyl carbocations: putative intermediates in the Schmidt reaction Journal of the American Chemical Society. 113: 1867-1869. DOI: 10.1021/Ja00005A081 |
0.376 |
|
| 1991 |
Richard JP, Amyes TL, Stevens IW. Generation and determination of the lifetime of an α-carbonyl substituted carbocation Tetrahedron Letters. 32: 4255-4258. DOI: 10.1016/S0040-4039(00)92142-7 |
0.305 |
|
| 1990 |
Richard JP, Amyes TL, Bei L, Stubblefield V. Effect of .beta.-fluorine substituents on the rate and equilibrium constants for the reactions of .alpha.-substituted 4-methoxybenzyl carbocations and on the reactivity of a simple quinone methide Journal of the American Chemical Society. 112: 9513-9519. DOI: 10.1021/Ja00182A010 |
0.378 |
|
| 1989 |
Richard JP. Aromatic substitution reactions of amines with ring-substituted 1-phenyl-2,2,2-trifluoroethyl carbocations Journal of the American Chemical Society. 111: 6735-6744. DOI: 10.1021/Ja00199A037 |
0.378 |
|
| 1989 |
Richard JP. Reduction of the 1-(4-thiomethylphenyl)-2,2,2-trifluoroethyl carbocation by sodium sulfite Tetrahedron Letters. 30: 23-26. DOI: 10.1016/S0040-4039(01)80312-9 |
0.376 |
|
| 1987 |
Richard JP. Desolvation-limited reactions of amines with the 1-(4-methylthiophenyl)-2, 2,2-trifluoroethyl carbocation Journal of the Chemical Society, Chemical Communications. 1768-1769. DOI: 10.1039/C39870001768 |
0.358 |
|
| 1985 |
Richard JP. Reaction of triosephosphate isomerase with L-glyceraldehyde 3-phosphate and triose 1,2-enediol 3-phosphate Biochemistry. 24: 949-953. PMID 3995002 DOI: 10.1021/Bi00325A021 |
0.501 |
|
| 1985 |
Rothenberg ME, Richard JP, Jencks WP. Equilibrium constants for the interconversion of substituted 1-phenylethyl alcohols and ethers. A measurement of intramolecular electrostatic interactions Journal of the American Chemical Society. 107: 1340-1346. DOI: 10.1021/JA00291A038 |
0.438 |
|
| 1985 |
Rothenberg ME, Richard JP, Jencks WP. Equilibrium constants for the interconversion of substituted 1-phenylethyl alcohols and ethers. A measurement of intramolecular electrostatic interactions Journal of the American Chemical Society. 107: 1340-1346. DOI: 10.1021/Ja00291A038 |
0.515 |
|
| 1985 |
ROTHENBERG ME, RICHARD JP, JENCKS WP. ChemInform Abstract: EQUILIBRIUM CONSTANTS FOR THE INTERCONVERSION OF SUBSTITUTED 1-PHENYLETHYL ALCOHOLS AND ETHERS. A MEASUREMENT OF INTRAMOLECULAR ELECTROSTATIC INTERACTIONS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198529093 |
0.443 |
|
| 1984 |
Sheu KF, Ho HT, Nolan LD, Markovitz P, Richard JP, Utter MF, Frey PA. Stereochemical course of thiophosphoryl group transfer catalyzed by mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 23: 1779-83. PMID 6372862 DOI: 10.1021/Bi00303A030 |
0.574 |
|
| 1984 |
Richard JP, Jencks WP. General base catalysis of the addition of hydroxylic reagents to unstable carbocations and its disappearance Journal of the American Chemical Society. 106: 1396-1401. DOI: 10.1021/JA00317A034 |
0.473 |
|
| 1984 |
Richard JP, Jencks WP. General base catalysis of the addition of hydroxylic reagents to unstable carbocations and its disappearance Journal of the American Chemical Society. 106: 1396-1401. DOI: 10.1021/Ja00317A034 |
0.519 |
|
| 1984 |
Richard JP, Jencks WP. Concerted bimolecular substitution reactions of 1-phenylethyl derivatives Journal of the American Chemical Society. 106: 1383-1396. DOI: 10.1021/JA00317A033 |
0.521 |
|
| 1984 |
Richard JP, Jencks WP. Reactions of substituted 1-phenylethyl carbocations with alcohols and other nucleophilic reagents Journal of the American Chemical Society. 106: 1373-1383. DOI: 10.1021/JA00317A032 |
0.468 |
|
| 1984 |
Richard JP, Rothenberg ME, Jencks WP. Formation and stability of ring-substituted 1-phenylethyl carbocations Journal of the American Chemical Society. 106: 1361-1372. DOI: 10.1021/JA00317A031 |
0.464 |
|
| 1984 |
Richard JP. Acid-base catalysis of the elimination and isomerization reactions of triose phosphates Journal of the American Chemical Society. 106: 4926-4936. DOI: 10.1002/Chin.198449252 |
0.393 |
|
| 1984 |
RICHARD JP, JENCKS WP. ChemInform Abstract: GENERAL BASE CATALYSIS OF THE ADDITION OF HYDROXYLIC REAGENTS TO UNSTABLE CARBOCATIONS AND ITS DISAPPEARANCE Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198424095 |
0.473 |
|
| 1984 |
RICHARD JP, JENCKS WP. ChemInform Abstract: REACTIONS OF SUBSTITUTED 1-PHENYLETHYL CARBOCATIONS WITH ALCOHOLS AND OTHER NUCLEOPHILIC REAGENTS Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198424094 |
0.472 |
|
| 1984 |
Richard JP, Jencks WP. Reactions of substituted 1-phenylethyl carbocations with alcohols and other nucleophilic reagents Journal of the American Chemical Society. 106: 1373-1383. DOI: 10.1002/Chin.198424094 |
0.529 |
|
| 1984 |
RICHARD JP, ROTHENBERG ME, JENCKS WP. ChemInform Abstract: FORMATION AND STABILITY OF RING-SUBSTITUTED 1-PHENYLETHYL CARBOCATIONS Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198424093 |
0.468 |
|
| 1984 |
Richard JP, Rothenberg ME, Jencks WP. Formation and stability of ring-substituted 1-phenylethyl carbocations Journal of the American Chemical Society. 106: 1361-1372. DOI: 10.1002/Chin.198424093 |
0.525 |
|
| 1984 |
RICHARD JP, JENCKS WP. ChemInform Abstract: CONCERTED BIMOLECULAR SUBSTITUTION REACTIONS OF 1-PHENYLETHYL DERIVATIVES Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198424089 |
0.521 |
|
| 1984 |
Richard JP, Jencks WP. Concerted bimolecular substitution reactions of 1-phenylethyl derivatives Journal of the American Chemical Society. 106: 1383-1396. DOI: 10.1002/Chin.198424089 |
0.575 |
|
| 1984 |
RICHARD JP, FREY PA. ChemInform Abstract: STEREOCHEMICAL COURSE OF PHOSPHOANHYDRIDE SYNTHESIS Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198406224 |
0.415 |
|
| 1983 |
Frey PA, Richard JP, Ho HT, Brody RS, Sammons RD, Sheu KF. Stereochemistry of selected phosphotransferases and nucleotidyltransferases. Methods in Enzymology. 87: 213-35. PMID 6294450 DOI: 10.1016/S0076-6879(82)87016-X |
0.555 |
|
| 1983 |
Richard JP, Frey PA. Stereochemical course of phosphoanhydride synthesis Journal of the American Chemical Society. 105: 6605-6609. DOI: 10.1002/Chin.198406224 |
0.47 |
|
| 1982 |
Richard JP, Jencks WP. Concerted SN2 displacement reactions of 1-phenylethyl chlorides Journal of the American Chemical Society. 104: 4691-4692. DOI: 10.1021/JA00381A038 |
0.504 |
|
| 1982 |
Richard JP, Jencks WP. Concerted SN2 displacement reactions of 1-phenylethyl chlorides Journal of the American Chemical Society. 104: 4691-4692. DOI: 10.1021/Ja00381A038 |
0.56 |
|
| 1982 |
Richard JP, Jencks WP. A simple relationship between carbocation lifetime and reactivity-selectivity relationships for the solvolysis of ring-substituted 1-phenylethyl derivatives Journal of the American Chemical Society. 104: 4689-4691. DOI: 10.1021/JA00381A037 |
0.415 |
|
| 1982 |
Richard JP, Frey PA. Synthesis of chiral [18O]phosphorothioate analogs of adenine nucleotides Journal of the American Chemical Society. 104: 3476-3481. DOI: 10.1021/Ja00376A038 |
0.509 |
|
| 1982 |
RICHARD JP, JENCKS WP. ChemInform Abstract: CONCERTED SN2 DISPLACEMENT REACTIONS OF 1-PHENYLETHYL CHLORIDES Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198247113 |
0.506 |
|
| 1982 |
RICHARD JP, JENCKS WP. ChemInform Abstract: A SIMPLE RELATIONSHIP BETWEEN CARBOCATION LIFETIME AND REACTIVITY-SELECTIVITY RELATIONSHIPS FOR THE SOLVOLYSIS OF RING-SUBSTITUTED 1-PHENYLETHYL DERIVATIVES Chemischer Informationsdienst. 13. DOI: 10.1002/CHIN.198247112 |
0.419 |
|
| 1982 |
Richard JP, Jencks WP. A simple relationship between carbocation lifetime and reactivity-selectivity relationships for the solvolysis of ring-substituted 1-phenylethyl derivatives Journal of the American Chemical Society. 104: 4689-4691. DOI: 10.1002/Chin.198247112 |
0.481 |
|
| 1982 |
RICHARD JP, FREY PA. ChemInform Abstract: SYNTHESIS OF CHIRAL (18O)PHOSPHOROTHIOATE ANALOGS OF ADENINE NUCLEOTIDES Chemischer Informationsdienst. 13. DOI: 10.1002/Chin.198239364 |
0.512 |
|
| 1980 |
Richard JP, Carr MC, Ives DH, Frey PA. The stereochemical course of thiophosphoryl group transfer catalyzed by adenosine kinase. Biochemical and Biophysical Research Communications. 94: 1052-6. PMID 6249295 DOI: 10.1016/0006-291X(80)90525-2 |
0.538 |
|
| 1980 |
Pliura DH, Schomburg D, Richard JP, Frey PA, Knowles JR. Stereochemical course of a phosphokinase using a chiral [18O]phosphorothioate. Comparison with the transfer of a chiral [16O,17O,18O]phosphoryl group. Biochemistry. 19: 325-9. PMID 6243477 DOI: 10.1021/Bi00543A012 |
0.532 |
|
| 1980 |
Sheu KF, Richard JP, Frey PA. Stereochemical courses of nucleotidyltransferase and phosphotransferase action. Uridine diphosphate glucose pyrophosphorylase, galactose-1-phosphate uridylyltransferase, adenylate kinase, and nucleoside diphosphate kinase. Biochemistry. 18: 5548-56. PMID 229894 DOI: 10.1021/Bi00592A004 |
0.484 |
|
| 1979 |
RICHARD JP, HO H, FREY PA. ChemInform Abstract: SYNTHESIS OF NUCLEOSIDE (18O)PYROPHOSPHOROTHIOATES WITH CHIRAL (18O)PHOSPHOROTHIOATE GROUPS OF KNOWN CONFIGURATION. STEREOCHEMICAL ORIENTATIONS OF ENZYMIC PHOSPHORYLATIONS OF CHIRAL (18O)PHOSPHOROTHIOATES Chemischer Informationsdienst. 10. DOI: 10.1002/Chin.197909339 |
0.529 |
|
| 1978 |
Richard JP, Frey PA. Stereochemical course of thiophosphoryl group transfer catalyzed by adenylate kinase Journal of the American Chemical Society. 100: 7757-7758. DOI: 10.1021/Ja00492A069 |
0.513 |
|
| 1978 |
Richard JP, Ho H, Frey PA. Synthesis of nucleoside [18O]pyrophosphorothioates with chiral [18O]phosphorothioate groups of known configuration. Stereochemical orientations of enzymic phosphorylations of chiral [18O]phosphorothioates Journal of the American Chemical Society. 100: 7756-7757. DOI: 10.1021/Ja00492A068 |
0.528 |
|
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