Kevin Wiehe, Ph.D. - Publications

Affiliations: 
2008 Boston University, Boston, MA, United States 
Area:
General Biophysics

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McNamara HA, Idris AH, Sutton HJ, Vistein R, Flynn BJ, Cai Y, Wiehe K, Lyke KE, Chatterjee D, Kc N, Chakravarty S, Lee Sim BK, Hoffman SL, Bonsignori M, Seder RA, et al. Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response. Cell Host & Microbe. PMID 32697938 DOI: 10.1016/J.Chom.2020.07.001  0.337
2020 Bradley T, Kuraoka M, Yeh CH, Tian M, Chen H, Cain DW, Chen X, Cheng C, Ellebedy AH, Parks R, Barr M, Sutherland LL, Scearce RM, Bowman CM, Bouton-Verville H, ... ... Wiehe K, et al. Immune checkpoint modulation enhances HIV-1 antibody induction. Nature Communications. 11: 948. PMID 32075963 DOI: 10.1038/S41467-020-14670-W  0.348
2020 Easterhoff D, Pollara J, Luo K, Janus B, Gohain N, Williams LD, Tay MZ, Monroe A, Peachman K, Choe M, Min S, Lusso P, Zhang P, Go EP, Desaire H, ... ... Wiehe K, et al. HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. Jci Insight. 5. PMID 31996483 DOI: 10.1172/Jci.Insight.131437  0.349
2020 Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, et al. Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nature Communications. 11: 520. PMID 31980614 DOI: 10.1038/S41467-019-14196-W  0.335
2019 Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, et al. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science (New York, N.Y.). 366. PMID 31806786 DOI: 10.1126/Science.Aay7199  0.356
2019 Easterhoff D, Pollara J, Luo K, Tolbert WD, Young B, Mielke D, Jha S, O'Connell RJ, Vasan S, Kim J, Michael NL, Excler JL, Robb ML, Rerks-Ngarm S, Kaewkungwal J, ... ... Wiehe K, et al. Boosting with AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency. Journal of Virology. PMID 31776278 DOI: 10.1128/Jvi.01120-19  0.342
2019 Sacks D, Bhiman JN, Wiehe K, Gorman J, Kwong PD, Morris L, Moore PL. Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage. Plos Pathogens. 15: e1008005. PMID 31479499 DOI: 10.1371/Journal.Ppat.1008005  0.348
2019 Tay MZ, Wiehe K, Pollara J. Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. Frontiers in Immunology. 10: 332. PMID 30873178 DOI: 10.3389/Fimmu.2019.00332  0.324
2019 Henderson R, Watts BE, Ergin HN, Anasti K, Parks R, Xia SM, Trama A, Liao HX, Saunders KO, Bonsignori M, Wiehe K, Haynes BF, Alam SM. Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies. Nature Communications. 10: 654. PMID 30737386 DOI: 10.1038/S41467-019-08415-7  0.315
2018 Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, ... Wiehe K, et al. Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nature Medicine. PMID 30552419 DOI: 10.1038/S41591-018-0315-0  0.305
2018 Bonsignori M, Scott E, Wiehe K, Easterhoff D, Alam SM, Hwang KK, Cooper M, Xia SM, Zhang R, Montefiori DC, Henderson R, Nie X, Kelsoe G, Moody MA, Chen X, et al. Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity. PMID 30552024 DOI: 10.1016/J.Immuni.2018.10.015  0.332
2018 van Eeden C, Wibmer CK, Scheepers C, Richardson SI, Nonyane M, Lambson B, Mkhize NN, Vijayakumar B, Sheng Z, Stanfield-Oakley S, Bhiman JN, Bekker V, Hermanus T, Mabvakure B, Ismail A, ... ... Wiehe K, et al. V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. Cell Reports. 25: 3123-3135.e6. PMID 30540944 DOI: 10.1016/J.Celrep.2018.11.058  0.327
2018 Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Scho N A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, ... Wiehe K, et al. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nature Medicine. PMID 29554083 DOI: 10.1038/Nm.4512  0.378
2018 Fera D, Lee MS, Wiehe K, Meyerhoff RR, Piai A, Bonsignori M, Aussedat B, Walkowicz WE, Ton T, Zhou JO, Danishefsky S, Haynes BF, Harrison SC. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nature Communications. 9: 1111. PMID 29549260 DOI: 10.1038/S41467-018-03565-6  0.362
2017 Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, et al. Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nature Communications. 8: 1732. PMID 29170366 DOI: 10.1038/S41467-017-01336-3  0.333
2017 Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, ... ... Wiehe K, et al. Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Science Immunology. 2. PMID 28783671 DOI: 10.1126/Sciimmunol.Aal2200  0.327
2017 Shen X, Bogers WM, Yates NL, Ferrari G, Dey AK, Williams WT, Jaeger FH, Wiehe K, Sawant S, Alam SM, LaBranche CC, Montefiori DC, Martin L, Srivastava I, Heeney J, et al. Crosslinking of a CD4 Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. Journal of Virology. PMID 28490585 DOI: 10.1128/Jvi.00401-17  0.37
2017 Alam SM, Aussedat B, Vohra Y, Ryan Meyerhoff R, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, ... ... Wiehe K, et al. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. Science Translational Medicine. 9. PMID 28298421 DOI: 10.1126/Scitranslmed.Aai7521  0.332
2017 Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, et al. Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies. Science Translational Medicine. 9. PMID 28298420 DOI: 10.1126/Scitranslmed.Aai7514  0.361
2017 Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, et al. Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates. Cell Reports. 18: 2175-2188. PMID 28249163 DOI: 10.1016/J.Celrep.2017.02.003  0.365
2017 Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, et al. Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial. Plos Pathogens. 13: e1006182. PMID 28235027 DOI: 10.1371/Journal.Ppat.1006182  0.325
2017 Kepler TB, Wiehe K. Genetic and structural analyses of affinity maturation in the humoral response to HIV-1. Immunological Reviews. 275: 129-144. PMID 28133793 DOI: 10.1111/Imr.12513  0.366
2017 Saunders KO, Nicely NI, Aussedat B, Wiehe K, Parks R, Vohra Y, Walkowicz WE, Park PK, Eaton A, Sutherland LL, Scearce R, Wu N, Bonsignori M, Meyerhoff RR, Lloyd KE, et al. HIV Envelope vaccination elicits asparagine 332 glycan-dependent antibodies that resemble broadly neutralizing antibody precursors Cell Reports. DOI: 10.2210/Pdb5Iie/Pdb  0.339
2016 Luo K, Liao HX, Zhang R, Easterhoff D, Wiehe K, Gurley TC, Armand LC, Allen AA, Von Holle TA, Marshall DJ, Whitesides JF, Pritchett J, Foulger A, Hernandez G, Parks R, et al. Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques. Jci Insight. 1: e88522. PMID 27942585 DOI: 10.1172/Jci.Insight.88522  0.302
2016 Zhang R, Verkoczy L, Wiehe K, Munir Alam S, Nicely NI, Santra S, Bradley T, Pemble CW, Zhang J, Gao F, Montefiori DC, Bouton-Verville H, Kelsoe G, Larimore K, Greenberg PD, et al. Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Science Translational Medicine. 8: 336ra62. PMID 27122615 DOI: 10.1126/Scitranslmed.Aaf0618  0.335
2016 Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, et al. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell. PMID 26949186 DOI: 10.1016/J.Cell.2016.02.022  0.31
2015 Nicely NI, Wiehe K, Kepler TB, Jaeger FH, Dennison SM, Rerks-Ngarm S, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Robb ML, O'Connell RJ, Michael NL, Kim JH, Liao HX, Munir Alam S, et al. Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. Ebiomedicine. 2: 713-22. PMID 26288844 DOI: 10.1016/J.Ebiom.2015.06.016  0.348
2015 Jeffries TL, Sacha CR, Pollara J, Himes J, Jaeger FH, Dennison SM, McGuire E, Kunz E, Eudailey JA, Trama AM, LaBranche C, Fouda GG, Wiehe K, Montefiori DC, Haynes BF, et al. The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells. Mucosal Immunology. PMID 26242599 DOI: 10.1038/Mi.2015.70  0.328
2015 Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, et al. HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science (New York, N.Y.). 349: aab1253. PMID 26229114 DOI: 10.1126/Science.Aab1253  0.317
2015 Liu M, Yang G, Wiehe K, Nicely NI, Vandergrift NA, Rountree W, Bonsignori M, Alam SM, Gao J, Haynes BF, Kelsoe G. Polyreactivity and autoreactivity among HIV-1 antibodies. Journal of Virology. 89: 784-98. PMID 25355869 DOI: 10.1128/Jvi.02378-14  0.375
2014 Wiehe K, Easterhoff D, Luo K, Nicely NI, Bradley T, Jaeger FH, Dennison SM, Zhang R, Lloyd KE, Stolarchuk C, Parks R, Sutherland LL, Scearce RM, Morris L, Kaewkungwal J, et al. Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved. Immunity. 41: 909-18. PMID 25526306 DOI: 10.1016/J.Immuni.2014.11.014  0.338
2014 Trama AM, Moody MA, Alam SM, Jaeger FH, Lockwood B, Parks R, Lloyd KE, Stolarchuk C, Scearce R, Foulger A, Marshall DJ, Whitesides JF, Jeffries TL, Wiehe K, Morris L, et al. HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host & Microbe. 16: 215-26. PMID 25121750 DOI: 10.1016/J.Chom.2014.07.003  0.327
2014 Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, et al. IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. Plos One. 9: e90725. PMID 24614505 DOI: 10.1371/Journal.Pone.0090725  0.321
2014 Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, et al. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. The Journal of Clinical Investigation. 124: 1835-43. PMID 24614107 DOI: 10.1172/Jci73441  0.32
2014 Pierce BG, Wiehe K, Hwang H, Kim BH, Vreven T, Weng Z. ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers. Bioinformatics (Oxford, England). 30: 1771-3. PMID 24532726 DOI: 10.1093/Bioinformatics/Btu097  0.755
2013 Liao HX, Lynch R, Zhou T, Gao F, Munir Alam S, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L, Mullikin JC, Gnanakaran S, Hraber P, ... Wiehe K, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature. 496: 469-476. PMID 23552890 DOI: 10.1038/Nature12053  0.367
2013 Liao HX, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, ... ... Wiehe K, et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 38: 176-86. PMID 23313589 DOI: 10.1016/J.Immuni.2012.11.011  0.37
2011 Hwang H, Vreven T, Whitfield TW, Wiehe K, Weng Z. A machine learning approach for the prediction of protein surface loop flexibility. Proteins. 79: 2467-74. PMID 21633973 DOI: 10.1002/Prot.23070  0.769
2007 Wiehe K, Peterson MW, Pierce B, Mintseris J, Weng Z. Protein-protein docking: Overview and performance analysis Methods in Molecular Biology. 413: 283-314. PMID 18075170 DOI: 10.1007/978-1-59745-574-9_11  0.78
2007 Wiehe K, Pierce B, Tong WW, Hwang H, Mintseris J, Weng Z. The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI. Proteins. 69: 719-25. PMID 17803212 DOI: 10.1002/Prot.21747  0.707
2007 Mintseris J, Pierce B, Wiehe K, Anderson R, Chen R, Weng Z. Integrating statistical pair potentials into protein complex prediction. Proteins. 69: 511-20. PMID 17623839 DOI: 10.1002/Prot.21502  0.773
2005 Mintseris J, Wiehe K, Pierce B, Anderson R, Chen R, Janin J, Weng Z. Protein-Protein Docking Benchmark 2.0: an update. Proteins. 60: 214-6. PMID 15981264 DOI: 10.1002/Prot.20560  0.758
2005 Wiehe K, Pierce B, Mintseris J, Tong WW, Anderson R, Chen R, Weng Z. ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. Proteins. 60: 207-13. PMID 15981263 DOI: 10.1002/Prot.20559  0.757
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