| Year |
Citation |
Score |
| 2018 |
Wong YH, Kumar A, Liew CW, Tharakaraman K, Srinivasaraghavan K, Sasisekharan R, Verma C, Lescar J. Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513. Scientific Reports. 8: 8449. PMID 29855525 DOI: 10.1038/S41598-018-26800-Y |
0.354 |
|
| 2018 |
Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, ... ... Sasisekharan R, et al. Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope. Cell Host & Microbe. 23: 618-627.e6. PMID 29746833 DOI: 10.1016/J.Chom.2018.04.004 |
0.327 |
|
| 2017 |
Raguram A, Sasisekharan V, Sasisekharan R. AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures. Trends in Microbiology. 25: 438-446. PMID 28094093 DOI: 10.1016/J.Tim.2016.12.007 |
0.326 |
|
| 2016 |
Macchi E, Rudd TR, Raman R, Sasisekharan R, Yates EA, Naggi A, Guerrini M, Elli S. Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. Biochemistry. 55: 6605-6616. PMID 27933797 DOI: 10.1021/Acs.Biochem.6B00693 |
0.347 |
|
| 2016 |
Raman R, Tharakaraman K, Sasisekharan V, Sasisekharan R. Glycan-protein interactions in viral pathogenesis. Current Opinion in Structural Biology. 40: 153-162. PMID 27792989 DOI: 10.1016/J.Sbi.2016.10.003 |
0.357 |
|
| 2016 |
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dančík V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R. A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza. Trends in Microbiology. PMID 27751627 DOI: 10.1016/J.Tim.2016.09.003 |
0.33 |
|
| 2016 |
Hussein IT, Krammer F, Ma E, Estrin M, Viswanathan K, Stebbins NW, Quinlan DS, Sasisekharan R, Runstadler J. New England harbor seal H3N8 influenza virus retains avian-like receptor specificity. Scientific Reports. 6: 21428. PMID 26888262 DOI: 10.1038/Srep21428 |
0.36 |
|
| 2015 |
Zhu X, Viswanathan K, Raman R, Yu W, Sasisekharan R, Wilson IA. Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Reports. PMID 26586437 DOI: 10.1016/J.Celrep.2015.10.027 |
0.375 |
|
| 2015 |
Lakdawala SS, Jayaraman A, Halpin RA, Lamirande EW, Shih AR, Stockwell TB, Lin X, Simenauer A, Hanson CT, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das SR, ... ... Sasisekharan R, et al. The soft palate is an important site of adaptation for transmissible influenza viruses. Nature. PMID 26416728 DOI: 10.1038/Nature15379 |
0.348 |
|
| 2015 |
Tharakaraman K, Subramanian V, Viswanathan K, Sloan S, Yen HL, Barnard DL, Leung YH, Szretter KJ, Koch TJ, Delaney JC, Babcock GJ, Wogan GN, Sasisekharan R, Shriver Z. A broadly neutralizing human monoclonal antibody is effective against H7N9. Proceedings of the National Academy of Sciences of the United States of America. 112: 10890-5. PMID 26283346 DOI: 10.1073/Pnas.1502374112 |
0.305 |
|
| 2015 |
Shriver Z, Trevejo JM, Sasisekharan R. Antibody-Based Strategies to Prevent and Treat Influenza. Frontiers in Immunology. 6: 315. PMID 26217334 DOI: 10.3389/Fimmu.2015.00315 |
0.308 |
|
| 2015 |
Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan B, ... ... Sasisekharan R, et al. Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Cell. 162: 493-504. PMID 26189681 DOI: 10.1016/J.Cell.2015.06.057 |
0.308 |
|
| 2015 |
Tharakaraman K, Sasisekharan R. Influenza surveillance: 2014-2015 H1N1 "swine"-derived influenza viruses from India. Cell Host & Microbe. 17: 279-82. PMID 25766285 DOI: 10.1016/J.Chom.2015.02.019 |
0.324 |
|
| 2015 |
Venkataraman M, Sasisekharan R, Raman R. Glycan array data management at Consortium for Functional Glycomics. Methods in Molecular Biology (Clifton, N.J.). 1273: 181-90. PMID 25753711 DOI: 10.1007/978-1-4939-2343-4_13 |
0.305 |
|
| 2015 |
Lakdawala SS, Shih AR, Jayaraman A, Lamirande EW, Moore I, Paskel M, Sasisekharan R, Subbarao K. Corrigendum to: "Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets" [Virology 446 (1-2) (2013) 349-356]doi: 10.1016/j.virol.2013.08.011 Virology. 486: 321. DOI: 10.1016/J.Virol.2015.11.010 |
0.316 |
|
| 2014 |
Raman R, Tharakaraman K, Shriver Z, Jayaraman A, Sasisekharan V, Sasisekharan R. Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus. Trends in Microbiology. 22: 632-41. PMID 25108746 DOI: 10.1016/J.Tim.2014.07.002 |
0.351 |
|
| 2014 |
Elli S, Macchi E, Rudd TR, Raman R, Sassaki G, Viswanathan K, Yates EA, Shriver Z, Naggi A, Torri G, Sasisekharan R, Guerrini M. Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies. Biochemistry. 53: 4122-35. PMID 24878075 DOI: 10.1021/Bi500338R |
0.372 |
|
| 2014 |
Tharakaraman K, Subramanian V, Cain D, Sasisekharan V, Sasisekharan R. Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure. Cell Host & Microbe. 15: 644-51. PMID 24832457 DOI: 10.1016/J.Chom.2014.04.009 |
0.334 |
|
| 2014 |
Stebbins NW, Sasisekharan R. Chapter 11 – Functional Glycomics Analysis: Challenges and Methodologies Comprehensive Analytical Chemistry. 63: 255-280. DOI: 10.1016/B978-0-444-62651-6.00011-8 |
0.349 |
|
| 2013 |
Lakdawala SS, Shih AR, Jayaraman A, Lamirande EW, Moore I, Paskel M, Sasisekharan R, Subbarao K. Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets. Virology. 446: 349-56. PMID 24074599 DOI: 10.1016/J.Virol.2013.08.011 |
0.341 |
|
| 2013 |
Sassaki GL, Elli S, Rudd TR, Macchi E, Yates EA, Naggi A, Shriver Z, Raman R, Sasisekharan R, Torri G, Guerrini M. Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution. Biochemistry. 52: 7217-30. PMID 24015903 DOI: 10.1021/Bi400677N |
0.323 |
|
| 2013 |
Tharakaraman K, Jayaraman A, Raman R, Viswanathan K, Stebbins NW, Johnson D, Shriver Z, Sasisekharan V, Sasisekharan R. Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell. 153: 1486-93. PMID 23746830 DOI: 10.1016/J.Cell.2013.05.034 |
0.374 |
|
| 2013 |
Tharakaraman K, Raman R, Viswanathan K, Stebbins NW, Jayaraman A, Krishnan A, Sasisekharan V, Sasisekharan R. Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell. 153: 1475-85. PMID 23746829 DOI: 10.1016/J.Cell.2013.05.035 |
0.354 |
|
| 2013 |
Sun X, Jayaraman A, Maniprasad P, Raman R, Houser KV, Pappas C, Zeng H, Sasisekharan R, Katz JM, Tumpey TM. N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses. Journal of Virology. 87: 8756-66. PMID 23740978 DOI: 10.1128/Jvi.00593-13 |
0.361 |
|
| 2013 |
Artpradit C, Robinson LN, Gavrilov BK, Rurak TT, Ruchirawat M, Sasisekharan R. Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles. Virus Research. 176: 69-77. PMID 23707399 DOI: 10.1016/J.Virusres.2013.04.017 |
0.346 |
|
| 2013 |
Tharakaraman K, Raman R, Stebbins NW, Viswanathan K, Sasisekharan V, Sasisekharan R. Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic. Scientific Reports. 3: 1822. PMID 23661027 DOI: 10.1038/Srep01822 |
0.332 |
|
| 2013 |
Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R. Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin. Plos One. 8: e59550. PMID 23626667 DOI: 10.1371/Journal.Pone.0059550 |
0.343 |
|
| 2013 |
Hobbie SN, Viswanathan K, Bachelet I, Aich U, Shriver Z, Subramanian V, Raman R, Sasisekharan R. Modular glycosphere assays for high-throughput functional characterization of influenza viruses. Bmc Biotechnology. 13: 34. PMID 23587408 DOI: 10.1186/1472-6750-13-34 |
0.362 |
|
| 2013 |
Tharakaraman K, Robinson LN, Hatas A, Chen YL, Siyue L, Raguram S, Sasisekharan V, Wogan GN, Sasisekharan R. Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency. Proceedings of the National Academy of Sciences of the United States of America. 110: E1555-64. PMID 23569282 DOI: 10.1073/Pnas.1303645110 |
0.315 |
|
| 2013 |
Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R. Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin. Plos One. 8: e49597. PMID 23437033 DOI: 10.1371/Journal.Pone.0049597 |
0.366 |
|
| 2013 |
Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R. Correction: Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin Plos One. 8. DOI: 10.1371/Annotation/C3B40A6F-A4Be-4117-8Ce2-A1B9B873E87C |
0.342 |
|
| 2012 |
Jayaraman A, Koh X, Li J, Raman R, Viswanathan K, Shriver Z, Sasisekharan R. Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors. The Biochemical Journal. 444: 429-35. PMID 22642577 DOI: 10.1042/Bj20112101 |
0.366 |
|
| 2012 |
Shriver Z, Capila I, Venkataraman G, Sasisekharan R. Heparin and heparan sulfate: analyzing structure and microheterogeneity. Handbook of Experimental Pharmacology. 159-76. PMID 22566225 DOI: 10.1007/978-3-642-23056-1_8 |
0.332 |
|
| 2012 |
Robinson LN, Artpradit C, Raman R, Shriver ZH, Ruchirawat M, Sasisekharan R. Harnessing glycomics technologies: integrating structure with function for glycan characterization. Electrophoresis. 33: 797-814. PMID 22522536 DOI: 10.1002/Elps.201100231 |
0.332 |
|
| 2012 |
Jayaraman A, Chandrasekaran A, Viswanathan K, Raman R, Fox JG, Sasisekharan R. Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract. Plos One. 7: e27517. PMID 22359533 DOI: 10.1371/Journal.Pone.0027517 |
0.341 |
|
| 2012 |
Pearce MB, Jayaraman A, Pappas C, Belser JA, Zeng H, Gustin KM, Maines TR, Sun X, Raman R, Cox NJ, Sasisekharan R, Katz JM, Tumpey TM. Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets. Proceedings of the National Academy of Sciences of the United States of America. 109: 3944-9. PMID 22355116 DOI: 10.1073/Pnas.1119945109 |
0.328 |
|
| 2011 |
Soundararajan V, Zheng S, Patel N, Warnock K, Raman R, Wilson IA, Raguram S, Sasisekharan V, Sasisekharan R. Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation. Scientific Reports. 1: 200. PMID 22355715 DOI: 10.1038/Srep00200 |
0.361 |
|
| 2011 |
Belser JA, Jayaraman A, Raman R, Pappas C, Zeng H, Cox NJ, Katz JM, Sasisekharan R, Tumpey TM. Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus. Plos One. 6: e25091. PMID 21966421 DOI: 10.1371/Journal.Pone.0025091 |
0.355 |
|
| 2011 |
Aich U, Shriver Z, Tharakaraman K, Raman R, Sasisekharan R. Competitive inhibition of heparinase by persulfonated glycosaminoglycans: a tool to detect heparin contamination. Analytical Chemistry. 83: 7815-22. PMID 21863856 DOI: 10.1021/Ac201498A |
0.317 |
|
| 2011 |
Aich U, Beckley N, Shriver Z, Raman R, Viswanathan K, Hobbie S, Sasisekharan R. Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay. The Febs Journal. 278: 1699-712. PMID 21410647 DOI: 10.1111/J.1742-4658.2011.08096.X |
0.394 |
|
| 2011 |
Jayaraman A, Pappas C, Raman R, Belser JA, Viswanathan K, Shriver Z, Tumpey TM, Sasisekharan R. A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets. Plos One. 6: e17616. PMID 21407805 DOI: 10.1371/Journal.Pone.0017616 |
0.358 |
|
| 2011 |
Maines TR, Chen LM, Van Hoeven N, Tumpey TM, Blixt O, Belser JA, Gustin KM, Pearce MB, Pappas C, Stevens J, Cox NJ, Paulson JC, Raman R, Sasisekharan R, Katz JM, et al. Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. Virology. 413: 139-47. PMID 21397290 DOI: 10.1016/J.Virol.2011.02.015 |
0.361 |
|
| 2011 |
Soundararajan V, Patel N, Subramanian V, Sasisekharan V, Sasisekharan R. The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation. Innate Immunity. 17: 548-57. PMID 20699282 DOI: 10.1177/1753425910377099 |
0.313 |
|
| 2010 |
Viswanathan K, Koh X, Chandrasekaran A, Pappas C, Raman R, Srinivasan A, Shriver Z, Tumpey TM, Sasisekharan R. Determinants of glycan receptor specificity of H2N2 influenza A virus hemagglutinin. Plos One. 5: e13768. PMID 21060797 DOI: 10.1371/Journal.Pone.0013768 |
0.373 |
|
| 2010 |
Viswanathan K, Chandrasekaran A, Srinivasan A, Raman R, Sasisekharan V, Sasisekharan R. Glycans as receptors for influenza pathogenesis. Glycoconjugate Journal. 27: 561-70. PMID 20734133 DOI: 10.1007/S10719-010-9303-4 |
0.388 |
|
| 2010 |
Pappas C, Viswanathan K, Chandrasekaran A, Raman R, Katz JM, Sasisekharan R, Tumpey TM. Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. Plos One. 5: e11158. PMID 20574518 DOI: 10.1371/Journal.Pone.0011158 |
0.358 |
|
| 2009 |
Hensley SE, Das SR, Bailey AL, Schmidt LM, Hickman HD, Jayaraman A, Viswanathan K, Raman R, Sasisekharan R, Bennink JR, Yewdell JW. Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science (New York, N.Y.). 326: 734-6. PMID 19900932 DOI: 10.1126/Science.1178258 |
0.353 |
|
| 2009 |
Bisio A, Vecchietti D, Citterio L, Guerrini M, Raman R, Bertini S, Eisele G, Naggi A, Sasisekharan R, Torri G. Structural features of low-molecular-weight heparins affecting their affinity to antithrombin. Thrombosis and Haemostasis. 102: 865-73. PMID 19888521 DOI: 10.1160/Th09-02-0081 |
0.327 |
|
| 2009 |
Myette JR, Soundararajan V, Behr J, Shriver Z, Raman R, Sasisekharan R. Heparin/heparan sulfate N-sulfamidase from Flavobacterium heparinum: structural and biochemical investigation of catalytic nitrogen-sulfur bond cleavage. The Journal of Biological Chemistry. 284: 35189-200. PMID 19726673 DOI: 10.1074/Jbc.M109.053835 |
0.325 |
|
| 2009 |
Myette JR, Soundararajan V, Shriver Z, Raman R, Sasisekharan R. Heparin/heparan sulfate 6-O-sulfatase from Flavobacterium heparinum: integrated structural and biochemical investigation of enzyme active site and substrate specificity. The Journal of Biological Chemistry. 284: 35177-88. PMID 19726671 DOI: 10.1074/Jbc.M109.053801 |
0.332 |
|
| 2009 |
Shriver Z, Raman R, Viswanathan K, Sasisekharan R. Context-specific target definition in influenza a virus hemagglutinin-glycan receptor interactions. Chemistry & Biology. 16: 803-14. PMID 19716471 DOI: 10.1016/J.Chembiol.2009.08.002 |
0.386 |
|
| 2009 |
Maines TR, Jayaraman A, Belser JA, Wadford DA, Pappas C, Zeng H, Gustin KM, Pearce MB, Viswanathan K, Shriver ZH, Raman R, Cox NJ, Sasisekharan R, Katz JM, Tumpey TM. Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science (New York, N.Y.). 325: 484-7. PMID 19574347 DOI: 10.1126/Science.1177238 |
0.34 |
|
| 2009 |
Soundararajan V, Tharakaraman K, Raman R, Raguram S, Shriver Z, Sasisekharan V, Sasisekharan R. Extrapolating from sequence--the 2009 H1N1 'swine' influenza virus. Nature Biotechnology. 27: 510-3. PMID 19513050 DOI: 10.1038/Nbt0609-510 |
0.324 |
|
| 2009 |
Prabhakar V, Capila I, Sasisekharan R. The structural elucidation of glycosaminoglycans. Methods in Molecular Biology (Clifton, N.J.). 534: 147-56. PMID 19277554 DOI: 10.1007/978-1-59745-022-5_11 |
0.319 |
|
| 2009 |
Prabhakar V, Capila I, Sasisekharan R. Glycosaminoglycan characterization methodologies: probing biomolecular interactions. Methods in Molecular Biology (Clifton, N.J.). 534: 331-40. PMID 19277541 DOI: 10.1007/978-1-59745-022-5_23 |
0.352 |
|
| 2009 |
Van Hoeven N, Pappas C, Belser JA, Maines TR, Zeng H, García-Sastre A, Sasisekharan R, Katz JM, Tumpey TM. Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proceedings of the National Academy of Sciences of the United States of America. 106: 3366-71. PMID 19211790 DOI: 10.1073/Pnas.0813172106 |
0.327 |
|
| 2009 |
Prabhakar V, Capila I, Soundararajan V, Raman R, Sasisekharan R. Recombinant expression, purification, and biochemical characterization of chondroitinase ABC II from Proteus vulgaris. The Journal of Biological Chemistry. 284: 974-82. PMID 18849565 DOI: 10.1074/Jbc.M806630200 |
0.346 |
|
| 2008 |
Guglier S, Hricovíni M, Raman R, Polito L, Torri G, Casu B, Sasisekharan R, Guerrini M. Minimum FGF2 binding structural requirements of heparin and heparan sulfate oligosaccharides as determined by NMR spectroscopy. Biochemistry. 47: 13862-9. PMID 19117094 DOI: 10.1021/Bi801007P |
0.325 |
|
| 2008 |
Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing JC, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey GS, Fraser B, Roy S, Rogers-Cotrone T, ... ... Sasisekharan R, et al. Contaminated heparin associated with adverse clinical events and activation of the contact system. The New England Journal of Medicine. 358: 2457-67. PMID 18434646 DOI: 10.1056/Nejmoa0803200 |
0.302 |
|
| 2008 |
Srinivasan A, Viswanathan K, Raman R, Chandrasekaran A, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R. Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses. Proceedings of the National Academy of Sciences of the United States of America. 105: 2800-5. PMID 18287068 DOI: 10.1073/Pnas.0711963105 |
0.34 |
|
| 2008 |
Chandrasekaran A, Srinivasan A, Raman R, Viswanathan K, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin. Nature Biotechnology. 26: 107-13. PMID 18176555 DOI: 10.1038/Nbt1375 |
0.346 |
|
| 2007 |
Vlodavsky I, Ilan N, Nadir Y, Brenner B, Katz BZ, Naggi A, Torri G, Casu B, Sasisekharan R. Heparanase, heparin and the coagulation system in cancer progression. Thrombosis Research. 120: S112-20. PMID 18023704 DOI: 10.1016/S0049-3848(07)70139-1 |
0.348 |
|
| 2007 |
Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD, et al. The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood. 110: 2041-8. PMID 17536013 DOI: 10.1182/Blood-2007-04-082495 |
0.315 |
|
| 2006 |
Prabhakar V, Sasisekharan R. The biosynthesis and catabolism of galactosaminoglycans. Advances in Pharmacology (San Diego, Calif.). 53: 69-115. PMID 17239763 DOI: 10.1016/S1054-3589(05)53005-9 |
0.324 |
|
| 2006 |
Prabhakar V, Capila I, Raman R, Srinivasan A, Bosques CJ, Pojasek K, Wrick MA, Sasisekharan R. The catalytic machinery of chondroitinase ABC I utilizes a calcium coordination strategy to optimally process dermatan sulfate. Biochemistry. 45: 11130-9. PMID 16964974 DOI: 10.1021/Bi0605484 |
0.322 |
|
| 2006 |
Berry D, Lynn DM, Berry E, Sasisekharan R, Langer R. Heparin localization and fine structure regulate Burkitt's lymphoma growth. Biochemical and Biophysical Research Communications. 348: 850-6. PMID 16904641 DOI: 10.1016/J.Bbrc.2006.07.128 |
0.323 |
|
| 2006 |
Vlodavsky I, Abboud-Jarrous G, Elkin M, Naggi A, Casu B, Sasisekharan R, Ilan N. The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiology of Haemostasis and Thrombosis. 35: 116-27. PMID 16855356 DOI: 10.1159/000093553 |
0.319 |
|
| 2006 |
Sasisekharan R, Raman R, Prabhakar V. Glycomics approach to structure-function relationships of glycosaminoglycans. Annual Review of Biomedical Engineering. 8: 181-231. PMID 16834555 DOI: 10.1146/Annurev.Bioeng.8.061505.095745 |
0.337 |
|
| 2006 |
Shaya D, Tocilj A, Li Y, Myette J, Venkataraman G, Sasisekharan R, Cygler M. Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product. The Journal of Biological Chemistry. 281: 15525-35. PMID 16565082 DOI: 10.1074/Jbc.M512055200 |
0.313 |
|
| 2005 |
Raman R, Raguram S, Venkataraman G, Paulson JC, Sasisekharan R. Glycomics: an integrated systems approach to structure-function relationships of glycans. Nature Methods. 2: 817-24. PMID 16278650 DOI: 10.1038/Nmeth807 |
0.327 |
|
| 2005 |
Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. The Journal of Biological Chemistry. 280: 40066-73. PMID 16192265 DOI: 10.1074/Jbc.M508136200 |
0.303 |
|
| 2005 |
Prabhakar V, Raman R, Capila I, Bosques CJ, Pojasek K, Sasisekharan R. Biochemical characterization of the chondroitinase ABC I active site. The Biochemical Journal. 390: 395-405. PMID 16108757 DOI: 10.1042/Bj20050532 |
0.331 |
|
| 2005 |
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, et al. Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. The Journal of Clinical Investigation. 115: 1163-76. PMID 15841211 DOI: 10.1172/Jci23424 |
0.303 |
|
| 2005 |
Raman R, Sasisekharan V, Sasisekharan R. Structural insights into biological roles of protein-glycosaminoglycan interactions. Chemistry & Biology. 12: 267-77. PMID 15797210 DOI: 10.1016/J.Chembiol.2004.11.020 |
0.348 |
|
| 2005 |
Prabhakar V, Capila I, Bosques CJ, Pojasek K, Sasisekharan R. Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification. The Biochemical Journal. 386: 103-12. PMID 15691229 DOI: 10.1042/Bj20041222 |
0.335 |
|
| 2004 |
Shriver Z, Raguram S, Sasisekharan R. Glycomics: a pathway to a class of new and improved therapeutics. Nature Reviews Drug Discovery. 3: 863-873. PMID 15459677 DOI: 10.1038/Nrd1521 |
0.301 |
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| 2004 |
Michel G, Pojasek K, Li Y, Sulea T, Linhardt RJ, Raman R, Prabhakar V, Sasisekharan R, Cygler M. The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery. The Journal of Biological Chemistry. 279: 32882-96. PMID 15155751 DOI: 10.1074/Jbc.M403421200 |
0.315 |
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| 2004 |
Berry D, Lynn DM, Sasisekharan R, Langer R. Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chemistry & Biology. 11: 487-98. PMID 15123243 DOI: 10.1016/J.Chembiol.2004.03.023 |
0.31 |
|
| 2004 |
Berry D, Shriver Z, Venkataraman G, Sasisekharan R. Quantitative assessment of FGF regulation by cell surface heparan sulfates. Biochemical and Biophysical Research Communications. 314: 994-1000. PMID 14751231 DOI: 10.1016/J.Bbrc.2003.12.188 |
0.329 |
|
| 2004 |
Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE, Campbell S, Iozzo RV. Biologically active decorin is a monomer in solution. The Journal of Biological Chemistry. 279: 6606-12. PMID 14660661 DOI: 10.1074/Jbc.M310342200 |
0.33 |
|
| 2003 |
Dull RO, Dinavahi R, Schwartz L, Humphries DE, Berry D, Sasisekharan R, Garcia JG. Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: a new role for the glycocalyx. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L986-95. PMID 12754183 DOI: 10.1152/Ajplung.00022.2003 |
0.3 |
|
| 2003 |
Berry D, Shriver Z, Natke B, Kwan CP, Venkataraman G, Sasisekharan R. Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1. The Biochemical Journal. 373: 241-9. PMID 12659634 DOI: 10.1042/Bj20021760 |
0.315 |
|
| 2003 |
Raman R, Venkataraman G, Ernst S, Sasisekharan V, Sasisekharan R. Structural specificity of heparin binding in the fibroblast growth factor family of proteins. Proceedings of the National Academy of Sciences of the United States of America. 100: 2357-62. PMID 12604799 DOI: 10.1073/Pnas.0437842100 |
0.366 |
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| 2003 |
Sundaram M, Qi Y, Shriver Z, Liu D, Zhao G, Venkataraman G, Langer R, Sasisekharan R. Rational design of low-molecular weight heparins with improved in vivo activity. Proceedings of the National Academy of Sciences of the United States of America. 100: 651-6. PMID 12525684 DOI: 10.1073/Pnas.252643299 |
0.333 |
|
| 2003 |
Myette JR, Shriver Z, Claycamp C, McLean MW, Venkataraman G, Sasisekharan R. The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. Molecular cloning, recombinant expression, and biochemical characterization. The Journal of Biological Chemistry. 278: 12157-66. PMID 12519775 DOI: 10.1074/Jbc.M211420200 |
0.333 |
|
| 2003 |
Raman R, Myette JR, Shriver Z, Pojasek K, Venkataraman G, Sasisekharan R. The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. A structural and biochemical study of the enzyme active site and saccharide substrate specificity. The Journal of Biological Chemistry. 278: 12167-74. PMID 12519774 DOI: 10.1074/Jbc.M211425200 |
0.343 |
|
| 2002 |
Guerrini M, Raman R, Venkataraman G, Torri G, Sasisekharan R, Casu B. A novel computational approach to integrate NMR spectroscopy and capillary electrophoresis for structure assignment of heparin and heparan sulfate oligosaccharides. Glycobiology. 12: 713-9. PMID 12460939 DOI: 10.1093/Glycob/Cwf084 |
0.353 |
|
| 2002 |
Sasisekharan R, Shriver Z, Venkataraman G, Narayanasami U. Roles of heparan-sulphate glycosaminoglycans in cancer. Nature Reviews. Cancer. 2: 521-8. PMID 12094238 DOI: 10.1038/Nrc842 |
0.333 |
|
| 2002 |
Liu J, Shriver Z, Pope RM, Thorp SC, Duncan MB, Copeland RJ, Raska CS, Yoshida K, Eisenberg RJ, Cohen G, Linhardt RJ, Sasisekharan R. Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. The Journal of Biological Chemistry. 277: 33456-67. PMID 12080045 DOI: 10.1074/Jbc.M202034200 |
0.384 |
|
| 2002 |
Pojasek K, Raman R, Kiley P, Venkataraman G, Sasisekharan R. Biochemical characterization of the chondroitinase B active site. The Journal of Biological Chemistry. 277: 31179-86. PMID 12063249 DOI: 10.1074/Jbc.M201552200 |
0.332 |
|
| 2002 |
Myette JR, Shriver Z, Kiziltepe T, McLean MW, Venkataraman G, Sasisekharan R. Molecular cloning of the heparin/heparan sulfate delta 4,5 unsaturated glycuronidase from Flavobacterium heparinum, its recombinant expression in Escherichia coli, and biochemical determination of its unique substrate specificity. Biochemistry. 41: 7424-34. PMID 12044176 DOI: 10.1021/Bi012147O |
0.308 |
|
| 2002 |
Liu D, Shriver Z, Qi Y, Venkataraman G, Sasisekharan R. Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans. Seminars in Thrombosis and Hemostasis. 28: 67-78. PMID 11885027 DOI: 10.1055/S-2002-20565 |
0.31 |
|
| 2002 |
Shriver Z, Liu D, Sasisekharan R. Emerging views of heparan sulfate glycosaminoglycan structure/activity relationships modulating dynamic biological functions. Trends in Cardiovascular Medicine. 12: 71-7. PMID 11852254 DOI: 10.1016/S1050-1738(01)00150-5 |
0.326 |
|
| 2002 |
Raman R, Myette J, Venkataraman G, Sasisekharan V, Sasisekharan R. Identification of structural motifs and amino acids within the structure of human heparan sulfate 3-O-sulfotransferase that mediate enzymatic function. Biochemical and Biophysical Research Communications. 290: 1214-9. PMID 11811992 DOI: 10.1006/Bbrc.2001.6267 |
0.335 |
|
| 2002 |
Myette JR, Shriver Z, Liu J, Venkataraman G, Rosenberg R, Sasisekharan R. Expression in Escherichia coli, purification and kinetic characterization of human heparan sulfate 3-O-sulfotransferase-1. Biochemical and Biophysical Research Communications. 290: 1206-13. PMID 11811991 DOI: 10.1006/Bbrc.2001.6268 |
0.327 |
|
| 2002 |
Liu D, Shriver Z, Venkataraman G, El Shabrawi Y, Sasisekharan R. Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 99: 568-73. PMID 11805315 DOI: 10.1073/Pnas.012578299 |
0.32 |
|
| 2001 |
Zhang L, Beeler DL, Lawrence R, Lech M, Liu J, Davis JC, Shriver Z, Sasisekharan R, Rosenberg RD. 6-O-sulfotransferase-1 represents a critical enzyme in the anticoagulant heparan sulfate biosynthetic pathway. The Journal of Biological Chemistry. 276: 42311-21. PMID 11551899 DOI: 10.1074/Jbc.M101441200 |
0.305 |
|
| 2001 |
Berry D, Kwan CP, Shriver Z, Venkataraman G, Sasisekharan R. Distinct heparan sulfate glycosaminoglycans are responsible for mediating fibroblast growth factor-2 biological activity through different fibroblast growth factor receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1422-4. PMID 11387244 DOI: 10.1096/Fj.00-0661Fje |
0.343 |
|
| 2001 |
Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, ... ... Sasisekharan R, et al. Cell surface glypicans are low-affinity endostatin receptors. Molecular Cell. 7: 811-22. PMID 11336704 DOI: 10.1016/S1097-2765(01)00225-8 |
0.339 |
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| 2000 |
Sasisekharan R, Venkataraman G. Heparin and heparan sulfate: biosynthesis, structure and function Current Opinion in Chemical Biology. 4: 626-631. PMID 11102866 DOI: 10.1016/S1367-5931(00)00145-9 |
0.34 |
|
| 2000 |
Shriver Z, Sundaram M, Venkataraman G, Fareed J, Linhardt R, Biemann K, Sasisekharan R. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin. Proceedings of the National Academy of Sciences of the United States of America. 97: 10365-70. PMID 10984532 DOI: 10.1073/Pnas.97.19.10365 |
0.322 |
|
| 2000 |
Shriver Z, Raman R, Venkataraman G, Drummond K, Turnbull J, Toida T, Linhardt R, Biemann K, Sasisekharan R. Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site. Proceedings of the National Academy of Sciences of the United States of America. 97: 10359-64. PMID 10984531 DOI: 10.1073/Pnas.97.19.10359 |
0.338 |
|
| 2000 |
Pojasek K, Shriver Z, Hu Y, Sasisekharan R. Histidine 295 and histidine 510 are crucial for the enzymatic degradation of heparan sulfate by heparinase III. Biochemistry. 39: 4012-4019. PMID 10747789 DOI: 10.1021/Bi992514K |
0.324 |
|
| 1999 |
Natke B, Venkataraman G, Nugent MA, Sasisekharan R. Heparinase treatment of bovine smooth muscle cells inhibits fibroblast growth factor-2 binding to fibroblast growth factor receptor but not FGF-2 mediated cellular proliferation. Angiogenesis. 3: 249-57. PMID 14517424 DOI: 10.1023/A:1009008824246 |
0.324 |
|
| 1999 |
Venkataraman G, Raman R, Sasisekharan V, Sasisekharan R. Molecular Characteristics Of Fibroblast Growth Factor-Fibroblast Growth Factor Receptor-Heparin-Like Glycosaminoglycan Complex Proceedings of the National Academy of Sciences of the United States of America. 96: 3658-3663. PMID 10097093 DOI: 10.1073/Pnas.96.7.3658 |
0.343 |
|
| 1999 |
Venkataraman G, Shriver Z, Davis JC, Sasisekharan R. Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans Proceedings of the National Academy of Sciences of the United States of America. 96: 1892-1897. PMID 10051565 DOI: 10.1073/Pnas.96.5.1892 |
0.305 |
|
| 1999 |
Liu D, Shriver Z, Godavarti R, Venkataraman G, Sasisekharan R. The calcium-binding sites of heparinase I from Flavobacterium heparinum are essential for enzymatic activity. Journal of Biological Chemistry. 274: 4089-4095. PMID 9933602 DOI: 10.1074/Jbc.274.7.4089 |
0.302 |
|
| 1998 |
Rhomberg AJ, Shriver Z, Biemann K, Sasisekharan R. Mass spectrometric evidence for the enzymatic mechanism of the depolymerization of heparin-like glycosaminoglycans by heparinase II. Proceedings of the National Academy of Sciences of the United States of America. 95: 12232-7. PMID 9770469 DOI: 10.1073/Pnas.95.21.12232 |
0.349 |
|
| 1998 |
Rhomberg AJ, Ernst S, Sasisekharan R, Biemann K. Mass spectrometric and capillary electrophoretic investigation of the enzymatic degradation of heparin-like glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America. 95: 4176-81. PMID 9539709 DOI: 10.1073/Pnas.95.8.4176 |
0.318 |
|
| 1998 |
Godavarti R, Sasisekharan R. Heparinase I from Flavobacterium heparinum ROLE OF POSITIVE CHARGE IN ENZYMATIC ACTIVITY Journal of Biological Chemistry. 273: 248-255. PMID 9417072 DOI: 10.1074/Jbc.273.1.248 |
0.323 |
|
| 1997 |
Sasisekharan R, Ernst S, Venkataraman G. On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis. 1: 45-54. PMID 14517393 DOI: 10.1023/A:1018318914258 |
0.336 |
|
| 1996 |
Godavarti R, Cooney CL, Langer R, Sasisekharan R. Heparinase I from Flavobacterium heparinum. Identification of a critical histidine residue essential for catalysis as probed by chemical modification and site-directed mutagenesis. Biochemistry. 35: 6846-52. PMID 8639636 DOI: 10.1021/Bi960356G |
0.34 |
|
| 1996 |
Sasisekharan R, Venkataraman G, Godavarti R, Ernst S, Cooney CL, Langer R. Heparinase I from Flavobacterium heparinum. Mapping and characterization of the heparin binding domain. The Journal of Biological Chemistry. 271: 3124-31. PMID 8621711 DOI: 10.1074/Jbc.271.6.3124 |
0.319 |
|
| 1996 |
Venkataraman G, Sasisekharan V, Herr AB, Ornitz DM, Waksman G, Cooney CL, Langer R, Sasisekharan R. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation Proceedings of the National Academy of Sciences of the United States of America. 93: 845-850. PMID 8570646 DOI: 10.1073/Pnas.93.2.845 |
0.314 |
|
| 1995 |
Ernst S, Langer R, Cooney CL, Sasisekharan R. Enzymatic degradation of glycosaminoglycans. Critical Reviews in Biochemistry and Molecular Biology. 30: 387-444. PMID 8575190 DOI: 10.3109/10409239509083490 |
0.365 |
|
| 1995 |
Sasisekharan R, Leckband D, Godavarti R, Venkataraman G, Cooney CL, Langer R. Heparinase I from Flavobacterium heparinum: the role of the cysteine residue in catalysis as probed by chemical modification and site-directed mutagenesis. Biochemistry. 34: 14441-8. PMID 7578049 DOI: 10.1021/Bi00044A022 |
0.31 |
|
| 1994 |
Sasisekharan R, Moses MA, Nugent MA, Cooney CL, Langer R. Heparinase inhibits neovascularization. Proceedings of the National Academy of Sciences of the United States of America. 91: 1524-8. PMID 7509076 DOI: 10.1073/Pnas.91.4.1524 |
0.354 |
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