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Guangyu Zhu, Ph.D. - Publications

Affiliations: 
Biology & Chemistry City University of Hong Kong, Kowloon, Hong Kong 
Area:
chemical biology, DNA repair
Website:
http://www6.cityu.edu.hk/bhdbapp/deptweb/profile/drgz.html
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yao H, Chen S, Deng Z, Tse MK, Matsuda Y, Zhu G. BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity. Inorganic Chemistry. 59: 11823-11833. PMID 32799491 DOI: 10.1021/Acs.Inorgchem.0C01880  0.389
2020 Deng Z, Wang N, Liu Y, Xu Z, Wang Z, Lau TC, Zhu G. A photocaged, water-oxidizing, and nucleolus-targeted Pt(IV) complex with a distinct anticancer mechanism. Journal of the American Chemical Society. PMID 32216337 DOI: 10.1021/Jacs.0C00221  0.388
2019 Xu Z, Li C, Zhou Q, Deng Z, Tong Z, Tse MK, Zhu G. Synthesis, Cytotoxicity, and Mechanistic Investigation of Platinum(IV) Anticancer Complexes Conjugated with Poly(ADP-ribose) Polymerase Inhibitors. Inorganic Chemistry. PMID 31738050 DOI: 10.1021/Acs.Inorgchem.9B02839  0.426
2019 Yao H, Xu Z, Li C, Tse MK, Tong Z, Zhu G. Synthesis and Cytotoxic Study of a Platinum(IV) Anticancer Prodrug with Selectivity toward Luteinizing Hormone-Releasing Hormone (LHRH) Receptor-Positive Cancer Cells. Inorganic Chemistry. PMID 31393117 DOI: 10.1021/Acs.Inorgchem.9B01583  0.373
2019 Li C, Li T, Huang L, Yang M, Zhu G. Self-assembled lipid nanoparticles for ratiometric codelivery of cisplatin and siRNA targeting XPF to combat drug resistance in lung cancer. Chemistry, An Asian Journal. PMID 30843348 DOI: 10.1002/Asia.201900005  0.377
2019 Wang Z, Deng Z, Zhu G. Emerging platinum(iv) prodrugs to combat cisplatin resistance: from isolated cancer cells to tumor microenvironment. Dalton Transactions (Cambridge, England : 2003). PMID 30633263 DOI: 10.1039/C8Dt03923B  0.346
2019 Wang Z, Wang N, Cheng S, Xu K, Deng Z, Chen S, Xu Z, Xie K, Tse M, Shi P, Hirao H, Ko C, Zhu G. Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light Chem. 5: 3151-3165. DOI: 10.1016/J.Chempr.2019.08.021  0.346
2018 Li Y, Yu WK, Chen L, Chan YS, Liu D, Fong CC, Xu T, Zhu G, Sun D, Yang M. Electrotaxis of tumor-initiating cells of H1975 lung adenocarcinoma cells is associated with both activation of stretch-activated cation channels (SACCs) and internal calcium release. Bioelectrochemistry (Amsterdam, Netherlands). 124: 80-92. PMID 30015269 DOI: 10.1016/J.Bioelechem.2018.03.013  0.336
2018 Xu Z, Chan HM, Li C, Wang Z, Tse MK, Tong Z, Zhu G. Synthesis, Structure, and Cytotoxicity of Oxaliplatin-Based Platinum(IV) Anticancer Prodrugs Bearing One Axial Fluoride. Inorganic Chemistry. PMID 29943979 DOI: 10.1021/Acs.Inorgchem.8B00706  0.322
2018 Ma L, Na W, Ma R, Li C, Tse MK, Zhu G. Monochalcoplatin: an actively transported, quickly reducible, and highly potent Pt(IV) anticancer prodrug. Angewandte Chemie (International Ed. in English). PMID 29806087 DOI: 10.1002/Anie.201804314  0.405
2018 Ai F, Wang N, Zhang X, Sun T, Zhu Q, Kong W, Wang F, Zhu G. An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy. Nanoscale. PMID 29451577 DOI: 10.1039/C7Nr06874C  0.328
2018 Ma L, Lin X, Li C, Xu Z, Chan CY, Tse MK, Shi P, Zhu G. A Cancer Cell-Selective and Low-Toxic Bifunctional Heterodinuclear Pt(IV)-Ru(II) Anticancer Prodrug. Inorganic Chemistry. PMID 29436828 DOI: 10.1021/Acs.Inorgchem.8B00053  0.352
2018 Wang N, Wang Z, Xu Z, Chen X, Zhu G. A cisplatin-loaded immuno-chemotherapeutic nanohybrid bearing immune checkpoint inhibitors for enhanced cervical cancer therapy. Angewandte Chemie (International Ed. in English). PMID 29405579 DOI: 10.1002/Anie.201800422  0.36
2017 Li C, Ip KW, Man WL, Song D, He ML, Yiu SM, Lau TC, Zhu G. Cytotoxic (salen)ruthenium(iii) anticancer complexes exhibit different modes of cell death directed by axial ligands. Chemical Science. 8: 6865-6870. PMID 29147511 DOI: 10.1039/C7Sc02205K  0.365
2017 Xu Z, Li C, Tong Z, Ma L, Tse M, Zhu G. Halogenated PtIV Complexes from N-Halosuccinimide Oxidation of PtII Antitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity European Journal of Inorganic Chemistry. 2017: 1706-1712. DOI: 10.1002/Ejic.201601130  0.363
2016 Wang Z, Xu Z, Zhu G. A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance. Angewandte Chemie (International Ed. in English). PMID 27736029 DOI: 10.1002/Anie.201608936  0.362
2016 Ma L, Ma R, Wang Z, Yiu SM, Zhu G. Heterodinuclear Pt(iv)-Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis. Chemical Communications (Cambridge, England). PMID 27506281 DOI: 10.1039/C6Cc04354B  0.336
2016 Ai F, Sun T, Xu Z, Wang Z, Kong W, To MW, Wang F, Zhu G. An upconversion nanoplatform for simultaneous photodynamic therapy and Pt chemotherapy to combat cisplatin resistance. Dalton Transactions (Cambridge, England : 2003). PMID 27430044 DOI: 10.1039/C6Dt01404F  0.362
2016 Zhang X, Ai F, Sun T, Wang F, Zhu G. Multimodal Upconversion Nanoplatform with a Mitochondria-Targeted Property for Improved Photodynamic Therapy of Cancer Cells. Inorganic Chemistry. PMID 27049165 DOI: 10.1021/Acs.Inorgchem.6B00020  0.302
2016 Zhu X, Yuen MF, Yan L, Zhang Z, Ai F, Yang Y, Yu PK, Zhu G, Zhang W, Chen X. Diamond-Nanoneedle-Array-Facilitated Intracellular Delivery and the Potential Influence on Cell Physiology. Advanced Healthcare Materials. PMID 26992125 DOI: 10.1002/Adhm.201500990  0.357
2016 Wang Z, Xu Z, Zhu G. Rücktitelbild: A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance (Angew. Chem. 50/2016) Angewandte Chemie. 128: 15910-15910. DOI: 10.1002/Ange.201610431  0.302
2015 Xu Z, Wang Z, Yiu SM, Zhu G. Mono- and di-bromo platinum(iv) prodrugs via oxidative bromination: synthesis, characterization, and cytotoxicity. Dalton Transactions (Cambridge, England : 2003). PMID 26514681 DOI: 10.1039/C5Dt03101J  0.369
2015 Wang Z, Ma R, Yan L, Chen X, Zhu G. Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. Chemical Communications (Cambridge, England). 51: 11587-90. PMID 26096645 DOI: 10.1039/C5Cc04376J  0.346
2015 Ma R, Wang Y, Yan L, Ma L, Wang Z, Chan HC, Chiu SK, Chen X, Zhu G. Efficient co-delivery of a Pt(IV) prodrug and a p53 activator to enhance the anticancer activity of cisplatin. Chemical Communications (Cambridge, England). 51: 7859-62. PMID 25854514 DOI: 10.1039/C4Cc09879J  0.345
2015 Ma L, Ma R, Wang Y, Zhu X, Zhang J, Chan HC, Chen X, Zhang W, Chiu SK, Zhu G. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Chemical Communications (Cambridge, England). 51: 6301-4. PMID 25644651 DOI: 10.1039/C4Cc10409A  0.37
2015 Wang Z, Ai F, Wang Z, Zhao W, Zhu G, Lin Z, Sun J. Organocatalytic asymmetric synthesis of 1,1-diarylethanes by transfer hydrogenation. Journal of the American Chemical Society. 137: 383-9. PMID 25482291 DOI: 10.1021/Ja510980D  0.316
2015 Zhu X, Kwok SY, Yuen MF, Yan L, Chen W, Yang Y, Wang Z, Yu KN, Zhu G, Zhang W, Chen X. Dense diamond nanoneedle arrays for enhanced intracellular delivery of drug molecules to cell lines Journal of Materials Science. 50: 7800-7807. DOI: 10.1007/S10853-015-9351-Z  0.356
2014 Ma R, Wang Z, Yan L, Chen X, Zhu G. Novel Pt-loaded layered double hydroxide nanoparticles for efficient and cancer-cell specific delivery of a cisplatin prodrug. Journal of Materials Chemistry. B. 2: 4868-4875. PMID 32261778 DOI: 10.1039/C4Tb00645C  0.336
2014 Wang B, Wang Z, Ai F, Tang WK, Zhu G. A monofunctional platinum(II)-based anticancer agent from a salicylanilide derivative: Synthesis, antiproliferative activity, and transcription inhibition. Journal of Inorganic Biochemistry. 142: 118-125. PMID 25450026 DOI: 10.1016/J.Jinorgbio.2014.10.003  0.391
2014 Wang B, Qian H, Yiu SM, Sun J, Zhu G. Platinated benzonaphthyridone is a stronger inhibitor of poly(ADP-ribose) polymerase-1 and a more potent anticancer agent than is the parent inhibitor. European Journal of Medicinal Chemistry. 71: 366-73. PMID 24361480 DOI: 10.1016/J.Ejmech.2013.10.062  0.407
2014 Wang Z, Qian H, Yiu SM, Sun J, Zhu G. Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity. Journal of Inorganic Biochemistry. 131: 47-55. PMID 24239912 DOI: 10.1016/J.Jinorgbio.2013.10.017  0.388
2013 Zhu G, Song L, Lippard SJ. Visualizing inhibition of nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells. Cancer Research. 73: 4451-60. PMID 23695549 DOI: 10.1158/0008-5472.Can-13-0198  0.339
2012 Zhu G, Myint M, Ang WH, Song L, Lippard SJ. Monofunctional platinum-DNA adducts are strong inhibitors of transcription and substrates for nucleotide excision repair in live mammalian cells. Cancer Research. 72: 790-800. PMID 22180496 DOI: 10.1158/0008-5472.Can-11-3151  0.371
2012 Daghestani HN, Zhu G, Johnston PA, Shinde SN, Brodsky JL, Day BW. Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport. Assay and Drug Development Technologies. 10: 46-60. PMID 21919741 DOI: 10.1089/Adt.2010.0367  0.742
2011 Graf N, Ang WH, Zhu G, Myint M, Lippard SJ. Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity. Chembiochem : a European Journal of Chemical Biology. 12: 1115-23. PMID 21452186 DOI: 10.1002/Cbic.201000724  0.332
2010 Wang D, Zhu G, Huang X, Lippard SJ. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proceedings of the National Academy of Sciences of the United States of America. 107: 9584-9. PMID 20448203 DOI: 10.1073/Pnas.1002565107  0.352
2009 Vogt A, McPherson PA, Shen X, Balachandran R, Zhu G, Raccor BS, Nelson SG, Tsang M, Day BW. High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs. Chemical Biology & Drug Design. 74: 358-68. PMID 19691472 DOI: 10.1111/J.1747-0285.2009.00866.X  0.776
2009 Zhu G, Lippard SJ. Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links. Biochemistry. 48: 4916-25. PMID 19364127 DOI: 10.1021/Bi900389B  0.34
2008 Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM, Pipas JM, Day BW, Wipf P, Brodsky JL. Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic & Medicinal Chemistry. 16: 3291-301. PMID 18164205 DOI: 10.1016/J.Bmc.2007.12.014  0.552
2007 Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW, Vogt A, Wipf P. Structure-activity and high-content imaging analyses of novel tubulysins. Chemical Biology & Drug Design. 70: 75-86. PMID 17683369 DOI: 10.1111/J.1747-0285.2007.00541.X  0.751
2006 Zhu G, Yang F, Balachandran R, Höök P, Vallee RB, Curran DP, Day BW. Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. Journal of Medicinal Chemistry. 49: 2063-76. PMID 16539395 DOI: 10.1021/Jm051030L  0.608
2005 Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry. 44: 15053-63. PMID 16274252 DOI: 10.1021/Bi050685L  0.722
2005 Shin Y, Fournier JH, Balachandran R, Madiraju C, Raccor BS, Zhu G, Edler MC, Hamel E, Day BW, Curran DP. Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. Organic Letters. 7: 2873-6. PMID 15987158 DOI: 10.1021/Ol050808U  0.719
2005 Janjic JM, Mu Y, Kendall C, Stephenson CR, Balachandran R, Raccor BS, Lu Y, Zhu G, Xie W, Wipf P, Day BW. New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. Bioorganic & Medicinal Chemistry. 13: 157-64. PMID 15582460 DOI: 10.1016/J.Bmc.2004.09.048  0.722
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