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Sachdev Sidhu - Publications

Affiliations: 
Molecular Genetics University of Toronto, Toronto, ON, Canada 
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, ... ... Sidhu SS, et al. Structural surfaceomics reveals an AML-specific conformation of integrin β as a CAR T cellular therapy target. Nature Cancer. PMID 37904046 DOI: 10.1038/s43018-023-00652-6  0.309
2023 Giang KA, Sidhu SS, Nilvebrant J. Construction of Synthetic Antibody Phage Display Libraries. Methods in Molecular Biology (Clifton, N.J.). 2702: 59-75. PMID 37679615 DOI: 10.1007/978-1-0716-3381-6_4  0.303
2021 Philpott DN, Gomis S, Wang H, Atwal R, Kelil A, Sack T, Morningstar B, Burnie C, Sargent EH, Angers S, Sidhu S, Kelley SO. Rapid On-Cell Selection of High-Performance Human Antibodies. Acs Central Science. 8: 102-109. PMID 35106377 DOI: 10.1021/acscentsci.1c01205  0.313
2021 Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. A T cell redirection platform for co-targeting dual antigens on solid tumors. Mabs. 13: 1933690. PMID 34190031 DOI: 10.1080/19420862.2021.1933690  0.314
2021 Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS. Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody That Targets Two Distinct Epitopes on αv Integrins. Journal of Molecular Biology. 167090. PMID 34090922 DOI: 10.1016/j.jmb.2021.167090  0.323
2020 Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, ... ... Sidhu S, et al. Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Cell Host & Microbe. PMID 32735849 DOI: 10.1016/J.Chom.2020.06.021  0.36
2020 Moffat J, Zhang X, Lawson K, Banerjee S, Wang X, Adams J, Pan J, Ailles L, Finelli A, Sidhu S. Abstract B49: Development and characterization of a novel CA9 targeting dual-antibody T-cell engager for renal cell carcinoma Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B49  0.379
2019 Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, ... Sidhu SS, et al. Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894493 DOI: 10.1073/Pnas.1817246116  0.321
2019 Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Scientific Reports. 9: 842. PMID 30696911 DOI: 10.1038/S41598-018-37462-1  0.331
2019 Vora P, Venugopal C, Chokshi C, Qazi M, Tatari N, Brown K, Yelle N, Adams J, Tieu D, Seyfrid M, Singh M, Savage N, Subapanditha M, Bakhshinyan D, Kuhlmann L, ... ... Sidhu S, et al. Abstract 570: A glioblastoma translational pipeline: discovery of novel tumor antigens that drive GBM recurrence Cancer Research. 79: 570-570. DOI: 10.1158/1538-7445.Am2019-570  0.344
2018 Liu H, Huang H, Voss C, Kaneko T, Qin W, Sidhu S, Shun-Cheng Li SS. Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family. Molecular & Cellular Proteomics : McP. PMID 30482845 DOI: 10.1074/Mcp.Ra118.001123  0.322
2018 Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu AX, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, ... ... Sidhu S, et al. Co-targeting ephrin receptor tyrosine kinases A2 and A3 in cancer stem cells reduces growth of recurrent glioblastoma. Cancer Research. PMID 29945963 DOI: 10.1158/0008-5472.Can-18-0267  0.353
2018 Nelson B, Adams J, Kuglstatter A, Li Z, Harris SF, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu SS. Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies. Journal of Molecular Biology. PMID 29778602 DOI: 10.1016/j.jmb.2018.05.018  0.301
2018 Vora P, Adams J, Singh M, Venugopal C, Tatari N, Chokshi C, Qazi M, Salim S, Mahendram S, Bakhshinyan D, London M, Savage N, Subapanditha M, McFarlane N, Pan J, ... ... Sidhu S, et al. Abstract 1763: BiTEs vs CAR-Ts: Preclinical targeting of CD133+ brain tumor initiating cells using immunotherapy-based treatment strategies Cancer Research. 78: 1763-1763. DOI: 10.1158/1538-7445.Am2018-1763  0.403
2017 Apel AR, Hoban K, Chuartzman S, Tonikian R, Sidhu S, Schuldiner M, Wendland B, Prosser D. Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif. Molecular Biology of the Cell. PMID 28701344 DOI: 10.1091/Mbc.E15-10-0731  0.365
2017 Liu H, Saxena A, Sidhu SS, Wu D. Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds. Frontiers in Immunology. 8: 38. PMID 28184223 DOI: 10.3389/fimmu.2017.00038  0.34
2017 Vora P, Chokshi C, Qazi M, Singh M, Venugopal C, Mahendram S, Adams J, Bakhshinyan D, London M, Singh J, Subapanditha M, McFarlane N, Pan J, Bramson J, Sidhu S, et al. Abstract 3758: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of glioblastoma Cancer Research. 77: 3758-3758. DOI: 10.1158/1538-7445.Am2017-3758  0.393
2017 Qazi M, Vora P, Chokshi C, Venugopal C, London M, Hu A, Subapandtiha M, Singh M, Adams J, Moffat J, Sidhu S, Singh SK. Abstract 3639: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in human glioblastoma Cancer Research. 77: 3639-3639. DOI: 10.1158/1538-7445.Am2017-3639  0.388
2017 Qazi M, Vora P, Venugopal C, Gorelik M, Singh M, Hu A, Subapanditha M, Chokshi C, Savage N, Yelle N, Adams J, Moffat J, Sidhu S, Singh S. IMMU-03. THERAPEUTIC TARGETING OF TUMORIGENIC
EphA2+/EphA3+ BRAIN TUMOR INITIATING CELLS WITH BISPECIFIC ANTIBODY IN HUMAN GLIOBLASTOMA Neuro-Oncology. 19: vi113-vi113. DOI: 10.1093/Neuonc/Nox168.462  0.38
2017 Singh M, Venugopal C, Vora P, Adams J, Pan J, Chokshi C, Murty N, Sidhu S, Moffat J, Singh S. CMET-35. PRELIMINARY SCREENING OF A NOVEL EpCAM BISPECIFIC T-CELL ENGAGER (BiTE) ANTIBODY TO TARGET A BMIC POPULATION IN HUMAN BRAIN METASTASES Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.182  0.369
2016 Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. Journal of Molecular Biology. PMID 27887869 DOI: 10.1016/j.jmb.2016.11.016  0.31
2016 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/Nm.4219  0.426
2016 Vora P, Qazi M, Chokshi C, Venugopal C, London M, Hu A, McFarlane N, Subapanditha M, Singh M, Mahendram S, Adams J, Moffat J, Sidhu S, Singh S. Abstract B092: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B092  0.416
2016 Vora P, Chokshi C, Qazi M, Venugopal C, Mahendram S, Singh M, Adams J, Bakhshinyan D, London M, Subapanditha M, McFarlane N, Pan J, Bramson J, Moffat J, Sidhu S, et al. Abstract B079: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of recurrent glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B079  0.388
2016 Steinhart Z, Hart T, Sidhu S, Moffat J, Angers S. Abstract IA13: Inhibiting the Wnt pathway with selective anti-Frizzled synthetic antibodies Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia13  0.419
2016 Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, Macleod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Driks P, Sidhu S, Roth FP, Rissland OS, Durocher D, et al. Abstract PR03: High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Pr03  0.355
2016 Tomic J, McLaughlin M, Geyer R, Sidhu S, Moffat J. Abstract 2972: Development and characterization of synthetic antibodies with a human framework that directly link metabolism to immune system in cancer cells Cancer Research. 76: 2972-2972. DOI: 10.1158/1538-7445.Am2016-2972  0.363
2016 Vora P, Venugopal C, Mahendram S, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, Adams J, McFarlane N, Sidhu S, Moffat J, Bramson J, Singh S. Abstract 2300: Human CD133-specific chimeric antigen receptor (CAR) modified T cells target patient-derived glioblastoma brain tumors Cancer Research. 76: 2300-2300. DOI: 10.1158/1538-7445.Am2016-2300  0.372
2016 Vora P, Venugopal C, Adams J, Pan J, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, McFarlane N, Bramson J, Sidhu S, Moffat J, Singh S. Abstract 1481: Preclinical validation of a novel CD133/CD3 bispecific T-cell engager (BiTE) antibody to target patient-derived glioblastoma cells Cancer Research. 76: 1481-1481. DOI: 10.1158/1538-7445.Am2016-1481  0.394
2016 Vora P, Venugopal C, Choksi C, Qazi M, Adams J, London M, Subapanditha M, Singh M, Bakshinyan D, Sidhu S, Moffat J, Singh S. PS2 - 172 Preclinical Validation of a Novel CD33/CD3 Bispecific T-Cell Engager (BiTE) Antibody to Target Patient-Derived Glioblastoma Cells Canadian Journal of Neurological Sciences. 43. DOI: 10.1017/Cjn.2016.367  0.371
2015 Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, et al. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. PMID 26627737 DOI: 10.1016/J.Cell.2015.11.015  0.344
2015 Huang H, Economopoulos NO, Liu BA, Uetrecht A, Gu J, Jarvik N, Nadeem V, Pawson T, Moffat J, Miersch S, Sidhu SS. Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display. Protein Science : a Publication of the Protein Society. 24: 1890-900. PMID 26332758 DOI: 10.1002/Pro.2799  0.348
2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Sidhu S, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/Mcp.O115.052209  0.429
2015 Luz D, Chen G, Maranhão AQ, Rocha LB, Sidhu S, Piazza RM. Development and characterization of recombinant antibody fragments that recognize and neutralize in vitro Stx2 toxin from Shiga toxin-producing Escherichia coli. Plos One. 10: e0120481. PMID 25790467 DOI: 10.1371/Journal.Pone.0120481  0.379
2015 Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS. Scalable high throughput selection from phage-displayed synthetic antibody libraries. Journal of Visualized Experiments : Jove. 51492. PMID 25651360 DOI: 10.3791/51492  0.301
2015 Griffin C, Miersch S, Marcon E, Banerjee S, Wells J, Hornsby M, Kossiakoff A, Koide S, Paduch M, Sidhu S, Moffat J. Validation of Recombinant Antibodies Against Human Transcription Factors The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.571.13  0.345
2014 Abu-Odeh M, Bar-Mag T, Huang H, Kim T, Salah Z, Abdeen SK, Sudol M, Reichmann D, Sidhu S, Kim PM, Aqeilan RI. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. The Journal of Biological Chemistry. 289: 8865-80. PMID 24550385 DOI: 10.1074/Jbc.M113.506790  0.333
2013 Owen SC, Patel N, Logie J, Pan G, Persson H, Moffat J, Sidhu SS, Shoichet MS. Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 395-404. PMID 23880472 DOI: 10.1016/J.Jconrel.2013.07.011  0.307
2013 Rojas G, Pupo A, Leon K, Avellanet J, Carmenate T, Sidhu S. Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping. Immunobiology. 218: 105-13. PMID 22459271 DOI: 10.1016/J.Imbio.2012.02.009  0.383
2012 Sidhu S. Synthetic Proteins Engineered for the Modulation of Cell Signaling Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2400  0.423
2008 Birtalan S, Zhang Y, Fellouse FA, Shao L, Schaefer G, Sidhu SS. The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies Journal of Molecular Biology. 377: 1518-1528. PMID 18336836 DOI: 10.1016/j.jmb.2008.01.093  0.316
2007 Fellouse FA, Esaki K, Birtalan S, Raptis D, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS. High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of Molecular Biology. 373: 924-40. PMID 17825836 DOI: 10.1016/J.Jmb.2007.08.005  0.312
2007 Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Molecular Systems Biology. 3: 116. PMID 17551511 DOI: 10.1038/Msb4100159  0.32
2006 Li B, Russell SJ, Compaan DM, Totpal K, Marsters SA, Ashkenazi A, Cochran AG, Hymowitz SG, Sidhu SS. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology. 361: 522-36. PMID 16859704 DOI: 10.1016/J.Jmb.2006.06.042  0.301
2004 Lee CV, Sidhu SS, Fuh G. Bivalent antibody phage display mimics natural immunoglobulin. Journal of Immunological Methods. 284: 119-32. PMID 14736422 DOI: 10.1016/J.JIM.2003.11.001  0.31
2001 Pelletier J, Sidhu S. Mapping protein-protein interactions with combinatorial biology methods Current Opinion in Biotechnology. 12: 340-347. PMID 11551461 DOI: 10.1016/S0958-1669(00)00225-1  0.305
1998 Baardsnes J, Sidhu S, MacLeod A, Elliott J, Morden D, Watson J, Borgford T. Streptomyces griseus Protease B: Secretion Correlates with the Length of the Propeptide Journal of Bacteriology. 180: 3241-3244. PMID 9620979 DOI: 10.1128/Jb.180.12.3241-3244.1998  0.323
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