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David Gate, PhD - Publications

Affiliations: 
2015 University of Southern California, Los Angeles, CA, United States 
 2015-2021 Neurology Stanford University, Palo Alto, CA 
 2021- Neurology Northwestern University, Evanston, IL 
Area:
Alzheimer's disease, Aging, Neuroimmunology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Piehl N, van Olst L, Ramakrishnan A, Teregulova V, Simonton B, Zhang Z, Tapp E, Channappa D, Oh H, Losada PM, Rutledge J, Trelle AN, Mormino EC, Elahi F, Galasko DR, ... ... Gate D, et al. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment. Cell. 185: 5028-5039.e13. PMID 36516855 DOI: 10.1016/j.cell.2022.11.019  0.504
2022 Altendorfer B, Unger MS, Poupardin R, Hoog A, Asslaber D, Gratz IK, Mrowetz H, Benedetti A, de Sousa DMB, Greil R, Egle A, Gate D, Wyss-Coray T, Aigner L. Transcriptomic Profiling Identifies CD8 T Cells in the Brain of Aged and Alzheimer's Disease Transgenic Mice as Tissue-Resident Memory T Cells. Journal of Immunology (Baltimore, Md. : 1950). 209: 1272-1285. PMID 36165202 DOI: 10.4049/jimmunol.2100737  0.56
2022 Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, ... ... Gate D, et al. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. Nature. PMID 35165441 DOI: 10.1038/s41586-021-04369-3  0.499
2021 Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, et al. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Science Translational Medicine. 13: eabg2919. PMID 34851695 DOI: 10.1126/scitranslmed.abg2919  0.669
2021 Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, et al. CD4 T cells contribute to neurodegeneration in Lewy body dementia. Science (New York, N.Y.). eabf7266. PMID 34648304 DOI: 10.1126/science.abf7266  0.495
2021 Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, ... Gate D, et al. Publisher Correction: Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature. PMID 34625744 DOI: 10.1038/s41586-021-04080-3  0.459
2021 Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, ... Gate D, et al. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature. PMID 34153974 DOI: 10.1038/s41586-021-03710-0  0.501
2021 Oh H, Leventhal O, Channappa D, Henderson VW, Wyss-Coray T, Lehallier B, Gate D. Methods to investigate intrathecal adaptive immunity in neurodegeneration. Molecular Neurodegeneration. 16: 3. PMID 33482851 DOI: 10.1186/s13024-021-00423-w  0.505
2020 Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, et al. Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature. PMID 32612231 DOI: 10.1038/S41586-020-2453-Z  0.515
2020 Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. PMID 31915375 DOI: 10.1038/S41586-019-1895-7  0.59
2019 Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T. Undulating changes in human plasma proteome profiles across the lifespan. Nature Medicine. 25: 1843-1850. PMID 31806903 DOI: 10.1038/S41591-019-0673-2  0.508
2019 Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. PMID 30944478 DOI: 10.1038/S41586-019-1088-4  0.717
2019 Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Berdnik D, Franceschi C, Wyss-Coray T. UNDULATIONS OF THE PLASMA PROTEOME DEFINE DISTINCT STAGES OF HUMAN LIFESPAN AND REVEAL ACCELERATED AGING IN ALZHEIMER’S DISEASE Alzheimer's & Dementia. 15: P1628. DOI: 10.1016/J.Jalz.2019.06.4862  0.49
2019 Gate D, Saligrama N, Yang A, Middeldorp J, Levanthal O, Chen K, Lehallier B, McBride A, Channappa D, Tam G, Kim Y, Greicius MD, Wagner AD, Davis M, Wyss-Coray T. O4-09-06: CLONALLY EXPANDED CD8 T CELLS PATROL ALZHEIMER'S CEREBROSPINAL FLUID Alzheimer's & Dementia. 15: P1257-P1258. DOI: 10.1016/J.Jalz.2019.06.4793  0.568
2018 Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. Journal of the American Chemical Society. PMID 29775058 DOI: 10.1021/Jacs.8B03074  0.501
2016 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology. PMID 27795421 DOI: 10.1128/Jvi.01529-16  0.638
2016 Mott KR, Gate D, Matundan HH, Ghiasi YN, Town T, Ghiasi H. CD8+ T cells play a bystander role in HSV-1 latently infected mice. Journal of Virology. PMID 26962220 DOI: 10.1128/Jvi.00255-16  0.595
2015 Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Müller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY. Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection. Plos Pathogens. 11: e1005292. PMID 26618545 DOI: 10.1371/Journal.Ppat.1005292  0.56
2015 Gate D, Danielpour M, Bannykh S, Town T. Characterization of cancer stem cells and primary cilia in medulloblastoma. Cns & Neurological Disorders Drug Targets. 14: 600-11. PMID 25921740 DOI: 10.2174/1871527314666150429113851  0.565
2015 Guillot-Sestier MV, Doty KR, Gate D, Rodriguez J, Leung BP, Rezai-Zadeh K, Town T. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron. 85: 534-48. PMID 25619654 DOI: 10.1016/J.Neuron.2014.12.068  0.701
2015 Gate D, Doty K, Leung B, Rodriguez J, Masliah E, Town T. O2-14-02: Irak-m removal endorses microglia-mediated amyloid phagocytosis and improves cognitive impairment in psapp mice Alzheimer's & Dementia. 11: P208-P208. DOI: 10.1016/J.Jalz.2015.07.209  0.693
2015 Guillot-Sestier M, Doty K, Gate D, Rodriguez J, Leung B, Rezai-Zadeh K, Town T. O2-05-02: Il10 deficiency licenses innate immunity to fight against cerebral amyloidosis Alzheimer's & Dementia. 11: P183-P184. DOI: 10.1016/J.Jalz.2015.07.155  0.68
2014 Weitz TM, Gate D, Rezai-Zadeh K, Town T. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. The American Journal of Pathology. 184: 2855-61. PMID 25174876 DOI: 10.1016/J.Ajpath.2014.07.004  0.621
2014 Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3458-66. PMID 25082897 DOI: 10.1073/Pnas.1412489111  0.631
2014 Town T, Gate D, Doty KR, Guillot-Sestier M, Weitz TM. S4-02-02: HARNESSING INNATE IMMUNITY TO TREAT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P240-P240. DOI: 10.1016/J.Jalz.2014.04.359  0.562
2014 Gate D, Rodriguez J, Leung B, Masliah E, Town T. O3-12-02: IRAK-M DELETION PROMOTES MICROGLIA-MEDIATED Aβ PHAGOCYTOSIS AND IMPROVES COGNITION IN PSAPP MICE Alzheimer's & Dementia. 10: P233-P233. DOI: 10.1016/J.Jalz.2014.04.336  0.695
2013 Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6245-56. PMID 23575824 DOI: 10.1523/Jneurosci.3672-12.2013  0.659
2013 Gate D, Kim G, Breunig J, Masliah E, Town T. P1-026: IRAK-M deletion promotes microglia-mediated beta-amyloid phagocytosis in PSAPP mice Alzheimer's & Dementia. 9: P161-P162. DOI: 10.1016/J.Jalz.2013.05.246  0.574
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/Journal.Pone.0044153  0.633
2012 Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Development. 7: 26. PMID 22776033 DOI: 10.1186/1749-8104-7-26  0.524
2012 Gate D, Danielpour M, Levy R, Breunig JJ, Town T. Basic biology and mechanisms of neural ciliogenesis and the B9 family. Molecular Neurobiology. 45: 564-70. PMID 22644387 DOI: 10.1007/S12035-012-8276-7  0.534
2012 Carvalho D, Bjerke L, Bax D, Chen L, Kozarewa I, Baker S, Grundy R, Ashworth A, Lord C, Hargrave D, Reis RM, Jones C, Bender S, Feng W, Jones DT, ... ... Gate D, et al. LAB-PEDIATRICS LABORATORY RESEARCH Neuro-Oncology. 14: vi116-vi119. DOI: 10.1093/Neuonc/Nos235  0.481
2012 Weitz T, Das M, Rezai-Zadeh K, Gate D, Town T. P2-119: MyD88 is dispensable for cerebral amyloid pathology and neuroinflammation in PSAPP transgenic mice Alzheimer's & Dementia. 8: P302-P303. DOI: 10.1016/J.Jalz.2012.05.824  0.588
2012 Breunig J, Rezai-Zadeh K, Rentsendorj A, Gate D, Cohen R, Town T. P2-416: Adult neurogenesis is diminished in a novel rat model of Alzheimer's disease Alzheimer's & Dementia. 8: P409-P410. DOI: 10.1016/J.Jalz.2012.05.2041  0.547
2012 Gate D, Rezai-Zadeh K, Masliah E, Town T. O4-07-01: IRAK-M deletion promotes microglia-mediated cerebral amyloid clearance in PSAPP mice Alzheimer's & Dementia. 8: P627-P627. DOI: 10.1016/J.Jalz.2012.05.1671  0.6
2011 Rezai-Zadeh K, Gate D, Gowing G, Town T. How to get from here to there: macrophage recruitment in Alzheimer's disease. Current Alzheimer Research. 8: 156-63. PMID 21345166 DOI: 10.2174/156720511795256017  0.62
2011 Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 85: 4184-97. PMID 21307196 DOI: 10.1128/Jvi.02290-10  0.53
2011 Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Investigative Ophthalmology & Visual Science. 52: 2321-33. PMID 21220560 DOI: 10.1167/Iovs.10-6536  0.661
2011 Gate D, Masliah E, Rezai-Zadeh K, Town T, Rentsendorj A. O1-03-05: IRAK-M deletion activates microglia and restricts cerebral amyloid in PSAPP mice Alzheimer's & Dementia. 7: S99-S99. DOI: 10.1016/J.Jalz.2011.05.243  0.595
2011 Rezai-Zadeh K, Breunig J, Rentsendorj A, Gate D, Cohen R, Town T. O3-04-03: Disrupted adult neurogenesis in a novel rat model of Alzheimer's disease Alzheimer's & Dementia. 7: S505-S505. DOI: 10.1016/J.Jalz.2011.05.1410  0.558
2010 Gate D, Rezai-Zadeh K, Jodry D, Rentsendorj A, Town T. Macrophages in Alzheimer's disease: the blood-borne identity. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 961-70. PMID 20517700 DOI: 10.1007/S00702-010-0422-7  0.607
2010 Rezai-Zadeh K, Gate D, Rentsendorj A, Jodry D, Mori T, Szekely CA, Tan J, Town T. P1-324: TGF-β and IL-10: An Alzheimer immunoregulatory duet? Alzheimer's & Dementia. 6: S267-S267. DOI: 10.1016/J.Jalz.2010.05.877  0.563
2010 Gate D, Rezai-Zadeh K, Goodridge H, Rodriguez J, Jodry D, Underhill D, Town T. P3-416: Differential TGF-β-Smad 2/3 and BMP-Smad 1/5/8 pathway activation promotes macrophage Aβ phagocytosis Alzheimer's & Dementia. 6: S574-S575. DOI: 10.1016/J.Jalz.2010.05.1959  0.539
2009 Rezai-Zadeh K, Gate D, Szekely CA, Town T. Can peripheral leukocytes be used as Alzheimer's disease biomarkers? Expert Review of Neurotherapeutics. 9: 1623-33. PMID 19903022 DOI: 10.1586/Ern.09.118  0.567
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/Journal.Ppat.1000610  0.617
2009 Rezai-Zadeh K, Gate D, Town T. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 462-75. PMID 19669892 DOI: 10.1007/S11481-009-9166-2  0.586
2006 Vesling AW, Gate D, Doty KR, Leung BPY, Rodriguez J, Uchoa MF, van't Veer C, Town T. P2-200: IRAK-M PROMOTES MICROGLIAL Aβ TOLERANCE BY ACTIVATING ALTERNATIVE NF-KB SIGNALING Alzheimer's & Dementia. 14: P745-P745. DOI: 10.1016/J.Jalz.2018.06.887  0.545
2006 Yan Leung BP, Doty KR, Miller CJ, Vesling AW, Uchoa MF, Im KW, Gate D, Quihuis AM, Guillot-Sestier M, Rodriguez J, Chang KT, Fahmy T, Tenner A, Colonna M, Town T. O4-02-03: PHYSICAL INTERACTION OF TREM2 AND C1Q IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1403-P1403. DOI: 10.1016/J.Jalz.2018.06.2917  0.563
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