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Stephen Cochrane - Publications

Affiliations: 
2010-2015 University of Alberta, Edmonton, Alberta, Canada 
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Karak M, Cloonan CR, Baker BR, Cochrane RVK, Cochrane SA. Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target. Beilstein Journal of Organic Chemistry. 20: 220-227. PMID 38352069 DOI: 10.3762/bjoc.20.22  0.543
2023 Buijs NP, Matheson EJ, Cochrane SA, Martin NI. Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic. Chemical Communications (Cambridge, England). PMID 37219335 DOI: 10.1039/d3cc01070h  0.624
2023 Ballantine RD, Al Ayed K, Bann SJ, Hoekstra M, Martin NI, Cochrane SA. Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity. Journal of Medicinal Chemistry. PMID 37071814 DOI: 10.1021/acs.jmedchem.3c00308  0.79
2022 Ballantine RD, Al Ayed K, Bann SJ, Hoekstra M, Martin NI, Cochrane SA. Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine. Rsc Medicinal Chemistry. 13: 1640-1643. PMID 36545437 DOI: 10.1039/d2md00281g  0.797
2022 Al Ayed K, Ballantine RD, Hoekstra M, Bann SJ, Wesseling CMJ, Bakker AT, Zhong Z, Li YX, Brüchle NC, van der Stelt M, Cochrane SA, Martin NI. Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and efficacy. Chemical Science. 13: 3563-3570. PMID 35432860 DOI: 10.1039/d2sc00143h  0.798
2021 Kotsogianni I, Wood TM, Alexander FM, Cochrane SA, Martin NI. Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin. Acs Infectious Diseases. PMID 34406007 DOI: 10.1021/acsinfecdis.1c00316  0.612
2021 Bann SJ, Ballantine RD, Cochrane SA. The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria. Rsc Medicinal Chemistry. 12: 538-551. PMID 34041489 DOI: 10.1039/d0md00413h  0.826
2020 Cochrane RVK, Alexander FM, Boland C, Fetics SK, Caffrey M, Cochrane SA. From plant to probe: semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets. Chemical Communications (Cambridge, England). PMID 32618302 DOI: 10.1039/D0Cc03388J  0.604
2020 Cochrane SA, Lohans CT. Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases. European Journal of Medicinal Chemistry. 194: 112262. PMID 32248005 DOI: 10.1016/j.ejmech.2020.112262  0.722
2019 Bann SJ, Ballantine RD, McCallion CE, Qian PY, Li Y, Cochrane SA. A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases. Journal of Medicinal Chemistry. PMID 31657913 DOI: 10.1021/Acs.Jmedchem.9B01078  0.802
2019 Chiorean S, Antwi I, Carney DW, Kotsogianni I, Giltrap AM, Alexander FM, Cochrane SA, Payne RJ, Martin NI, Henninot A, Vederas JC. Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. Chembiochem : a European Journal of Chemical Biology. PMID 31552694 DOI: 10.1002/Cbic.201900504  0.765
2019 Ballantine RD, McCallion CE, Nassour E, Tokajian S, Cochrane SA. Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria. Medchemcomm. 10: 484-487. PMID 31015912 DOI: 10.1039/c9md00031c  0.803
2018 Dong YY, Wang H, Pike ACW, Cochrane SA, Hamedzadeh S, Wyszyński FJ, Bushell SR, Royer SF, Widdick DA, Sajid A, Boshoff HI, Park Y, Lucas R, Liu WM, Lee SS, et al. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell. 175: 1045-1058.e16. PMID 30388443 DOI: 10.1016/J.Cell.2018.10.037  0.306
2018 Ballantine RD, Li YX, Qian PY, Cochrane SA. Rational design of new cyclic analogues of the antimicrobial lipopeptide tridecaptin A. Chemical Communications (Cambridge, England). PMID 30179243 DOI: 10.1039/C8Cc05790G  0.793
2017 Bakhtiary A, Cochrane SA, Mercier P, McKay RT, Miskolzie M, Sit CS, Vederas JC. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147. Journal of the American Chemical Society. PMID 29164875 DOI: 10.1021/Jacs.7B04728  0.776
2016 Cochrane SA, Findlay B, Bakhtiary A, Acedo JZ, Rodriguez-Lopez EM, Mercier P, Vederas JC. Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II. Proceedings of the National Academy of Sciences of the United States of America. PMID 27688760 DOI: 10.1073/Pnas.1608623113  0.72
2015 Cochrane SA, Li X, He S, Yu M, Wu M, Vederas JC. Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria. Journal of Medicinal Chemistry. PMID 26636619 DOI: 10.1021/Acs.Jmedchem.5B01578  0.62
2015 Cochrane SA, Surgenor RR, Khey KM, Vederas JC. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1. Organic Letters. 17: 5428-31. PMID 26465807 DOI: 10.1021/Acs.Orglett.5B02779  0.562
2015 Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC. Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria. Organic & Biomolecular Chemistry. 13: 6073-81. PMID 25959079 DOI: 10.1039/C5Ob00780A  0.774
2014 Kwon M, Cochrane SA, Vederas JC, Ro DK. Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis). Febs Letters. 588: 4597-603. PMID 25447532 DOI: 10.1016/J.Febslet.2014.10.031  0.441
2014 Cochrane SA, Vederas JC. Unacylated tridecaptin A₁ acts as an effective sensitiser of Gram-negative bacteria to other antibiotics. International Journal of Antimicrobial Agents. 44: 493-9. PMID 25315408 DOI: 10.1016/J.Ijantimicag.2014.08.008  0.61
2014 Cochrane SA, Vederas JC. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates. Medicinal Research Reviews. PMID 24866700 DOI: 10.1002/Med.21321  0.643
2014 Cochrane SA, Findlay B, Vederas JC, Ratemi ES. Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane. Chembiochem : a European Journal of Chemical Biology. 15: 1295-9. PMID 24816483 DOI: 10.1002/Cbic.201402024  0.73
2014 Cochrane SA, Lohans CT, Brandelli JR, Mulvey G, Armstrong GD, Vederas JC. Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1). Journal of Medicinal Chemistry. 57: 1127-31. PMID 24479847 DOI: 10.1021/Jm401779D  0.797
2014 Lohans CT, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC. Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni. Chembiochem : a European Journal of Chemical Biology. 15: 243-9. PMID 24382692 DOI: 10.1002/Cbic.201300595  0.737
2013 Cochrane SA, Huang Z, Vederas JC. Investigation of the ring-closing metathesis of peptides in water. Organic & Biomolecular Chemistry. 11: 630-9. PMID 23212663 DOI: 10.1039/C2Ob26938D  0.654
2011 Liu W, Chan AS, Liu H, Cochrane SA, Vederas JC. Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147. Journal of the American Chemical Society. 133: 14216-9. PMID 21848315 DOI: 10.1021/Ja206017P  0.692
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