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Pawel Lorkiewicz - Publications

Affiliations: 
University of Louisville, Louisville, KY, United States 
Area:
stable isotope resolved metabolomics, mass spectrometry, tobacco products, metabolomics, method development
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN. Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer. Metabolites. 13. PMID 37512481 DOI: 10.3390/metabo13070774  0.564
2022 Calderin EP, Zheng JJ, Boyd NL, McNally L, Lorkiewicz P, Hill BG, Hellmann J. Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages. Molecular Metabolism. 101637. PMID 36400404 DOI: 10.1016/j.molmet.2022.101637  0.508
2022 Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Glutamine uptake and catabolism is required for myofibroblast formation and persistence. Journal of Molecular and Cellular Cardiology. 172: 78-89. PMID 35988357 DOI: 10.1016/j.yjmcc.2022.08.002  0.571
2022 Fulghum KL, Smith JB, Chariker J, Garrett LF, Brittian KR, Lorkiewicz P, McNally LA, Uchida S, Jones SP, Hill BG, Collins HE. Metabolic Signatures of Pregnancy-Induced Cardiac Growth. American Journal of Physiology. Heart and Circulatory Physiology. PMID 35622533 DOI: 10.1152/ajpheart.00105.2022  0.552
2022 Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation. 145: 1625-1628. PMID 35605036 DOI: 10.1161/CIRCULATIONAHA.121.057879  0.526
2022 Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, et al. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. PMID 35061545 DOI: 10.1161/CIRCULATIONAHA.121.057641  0.552
2021 Fulghum KL, Audam TN, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, Hill BG. In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium. Journal of Molecular and Cellular Cardiology. PMID 34487754 DOI: 10.1016/j.yjmcc.2021.08.013  0.691
2021 Abouleisa RRE, McNally L, Salama ABM, Hammad SK, Ou Q, Wells C, Lorkiewicz PK, Bolli R, Mohamed TMA, Hill BG. Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation. Redox Biology. 46: 102094. PMID 34418597 DOI: 10.1016/j.redox.2021.102094  0.602
2020 Conroy LR, Lorkiewicz P, He L, Yin X, Zhang X, Rai SN, Clem BF. Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells. Cancer Cell International. 20: 280. PMID 32624705 DOI: 10.1186/S12935-020-01357-X  0.385
2020 Conroy LR, Dougherty S, Kruer T, Metcalf S, Lorkiewicz P, He L, Yin X, Zhang X, Arumugam S, Young LEA, Sun RC, Clem BF. Loss of Enhances Glycolytic Metabolism in -Driven Lung Tumors In Vivo. Cancers. 12. PMID 31963621 DOI: 10.3390/Cancers12010237  0.401
2019 Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, et al. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature Communications. 10: 4509. PMID 31586055 DOI: 10.1038/S41467-019-12103-X  0.567
2019 Lorkiewicz PK, Gibb AA, Rood BR, He L, Zheng Y, Clem BF, Zhang X, Hill BG. Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation. Scientific Reports. 9: 13705. PMID 31548575 DOI: 10.1038/S41598-019-50183-3  0.582
2019 Gibb AA, Lombardi AA, Murray EK, Tan Y, Lorkiewicz PK, Huynh AT, Kolmetzky DW, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.517  0.53
2018 Mehra P, Guo Y, Nong Y, Lorkiewicz P, Nasr M, Li Q, Muthusamy S, Bradley JA, Bhatnagar A, Wysoczynski M, Bolli R, Hill BG. Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair. Basic Research in Cardiology. 113: 46. PMID 30353243 DOI: 10.1007/S00395-018-0703-0  0.617
2018 Xie Z, Lorkiewicz P, Riggs DW, Bhatnagar A, Srivastava S. Comprehensive, robust, and sensitive UPLC-MS/MS analysis of free biogenic monoamines and their metabolites in urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1099: 83-91. PMID 30248561 DOI: 10.1016/J.Jchromb.2018.09.012  0.348
2017 Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Correction: Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. The Biochemical Journal. 474: 4271-4272. PMID 29242383 DOI: 10.1042/BCJ20170474_COR  0.569
2017 Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. The Biochemical Journal. PMID 28706006 DOI: 10.1042/Bcj20170474  0.602
2017 Wei X, Shi B, Koo I, Yin X, Lorkiewicz P, Suhail H, Rattan R, Giri S, McClain CJ, Zhang X. Analysis of stable isotope assisted metabolomics data acquired by GC-MS. Analytica Chimica Acta. 980: 25-32. PMID 28622800 DOI: 10.1016/J.Aca.2017.05.002  0.343
2017 Conklin DJ, Malovichko MV, Zeller I, Das TP, Krivokhizhina TV, Lynch BH, Lorkiewicz P, Agarwal A, Wickramasinghe N, Haberzettl P, Sithu SD, Shah J, O'Toole TE, Rai SN, Bhatnagar A, et al. Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28482051 DOI: 10.1093/Toxsci/Kfx095  0.302
2016 Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG. Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. The Journal of Biological Chemistry. PMID 27151219 DOI: 10.1074/Jbc.M116.722496  0.564
2015 Salabei JK, Lorkiewicz PK, Holden CR, Li Q, Hong KU, Bolli R, Bhatnagar A, Hill BG. Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation. Stem Cells (Dayton, Ohio). 33: 2613-27. PMID 25917428 DOI: 10.1002/Stem.2047  0.621
2015 Lane AN, Arumugam S, Lorkiewicz PK, Higashi RM, Laulhé S, Nantz MH, Moseley HN, Fan TW. Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance. Magnetic Resonance in Chemistry : Mrc. 53: 337-43. PMID 25616249 DOI: 10.1002/Mrc.4199  0.536
2014 Higashi RM, Fan TW, Lorkiewicz PK, Moseley HN, Lane AN. Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS. Methods in Molecular Biology (Clifton, N.J.). 1198: 147-67. PMID 25270929 DOI: 10.1007/978-1-4939-1258-2_11  0.564
2014 Ren JG, Seth P, Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, Sukhatme VP. Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling. Scientific Reports. 4: 5414. PMID 24957098 DOI: 10.1038/srep05414  0.565
2014 Gori SS, Lorkiewicz P, Ehringer DS, Belshoff AC, Higashi RM, Fan TW, Nantz MH. Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry. Analytical and Bioanalytical Chemistry. 406: 4371-9. PMID 24858467 DOI: 10.1007/S00216-014-7810-Z  0.695
2014 Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, et al. Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metabolism. 19: 795-809. PMID 24726384 DOI: 10.1016/J.Cmet.2014.03.003  0.556
2014 Guin S, Pollard C, Ru Y, Ritterson Lew C, Duex JE, Dancik G, Owens C, Spencer A, Knight S, Holemon H, Gupta S, Hansel D, Hellerstein M, Lorkiewicz P, Lane AN, et al. Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease. Journal of the National Cancer Institute. 106. PMID 24700805 DOI: 10.1093/Jnci/Dju062  0.54
2013 Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 23: 316-31. PMID 23453623 DOI: 10.1016/J.Ccr.2013.01.022  0.587
2012 Lorkiewicz P, Higashi RM, Lane AN, Fan TW. High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS. Metabolomics : Official Journal of the Metabolomic Society. 8: 930-939. PMID 23101002 DOI: 10.1007/S11306-011-0388-Y  0.597
2012 Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metabolism. 15: 110-21. PMID 22225880 DOI: 10.1016/J.Cmet.2011.12.009  0.584
2012 Fan TW, Lorkiewicz PK, Sellers K, Moseley HN, Higashi RM, Lane AN. Stable isotope-resolved metabolomics and applications for drug development. Pharmacology & Therapeutics. 133: 366-91. PMID 22212615 DOI: 10.1016/j.pharmthera.2011.12.007  0.576
2011 Fan TW, Lorkiewicz P, Higashi RM, Lane AN. Abstract LB-259: The gluconeogenic pathway is operative in lung cancer cells Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-259  0.415
2011 Fan TW, Lorkiewicz P, Higashi RM, Lane AN. Abstract 1251: Anti-cancer mechanisms of se compounds: A stable isotope-resolved metabolomic (SIRM) approach Cancer Research. 71: 1251-1251. DOI: 10.1158/1538-7445.Am2011-1251  0.447
2009 Lorkiewicz P, Yappert MC. Titania microparticles and nanoparticles as matrixes for in vitro and in situ analysis of small molecules by MALDI-MS. Analytical Chemistry. 81: 6596-603. PMID 20337373 DOI: 10.1021/Ac9001113  0.581
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