Year |
Citation |
Score |
2019 |
Zimmerman T, Lacal JC, Ibrahim SA. Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria. Frontiers in Microbiology. 6: 2146. PMID 31681254 DOI: 10.3389/Fmicb.2019.02146 |
0.309 |
|
2017 |
Valdés-Mora F, Locke WJ, Bandrés E, Gallego-Ortega D, Cejas P, García-Cabezas MA, Colino-Sanguino Y, Feliú J, Del Pulgar TG, Lacal JC. Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer. Oncotarget. 8: 26755-26770. PMID 28460460 DOI: 10.18632/Oncotarget.15815 |
0.361 |
|
2016 |
Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette Brown J, Hu Y, Dienemann H, Thomas M, ... ... Lacal JC, et al. Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Oncotarget. PMID 26862848 DOI: 10.18632/Oncotarget.7179 |
0.312 |
|
2016 |
Lacal JC, Andera L. Choline kinase inhibitors synergize with TRAIL in the treatment of colorectal tumors and overcomes TRAIL resistance Cancer Translational Medicine. 2: 163. DOI: 10.4103/2395-3977.196910 |
0.375 |
|
2015 |
Estévez-Braun A, Ravelo AG, Pérez-Sacau E, Lacal JC. A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products. Clinical & Translational Oncology. 17: 74-84. PMID 25472447 DOI: 10.1007/S12094-014-1260-0 |
0.399 |
|
2013 |
Zimmerman T, Moneriz C, Diez A, Bautista JM, Gómez Del Pulgar T, Cebrián A, Lacal JC. Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase. Antimicrobial Agents and Chemotherapy. 57: 5878-88. PMID 24041883 DOI: 10.1128/Aac.00920-13 |
0.303 |
|
2013 |
Cueva Adl, Molina ARd, Álvarez-Ayerza N, Ramos MA, Cebrián A, Pulgar TGd, Lacal JC. Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts Plos One. 8. PMID 23762272 DOI: 10.1371/Journal.Pone.0064961 |
0.362 |
|
2013 |
Casado-Vela J, Lacal JC, Elortza F. Protein chimerism: novel source of protein diversity in humans adds complexity to bottom-up proteomics. Proteomics. 13: 5-11. PMID 23161619 DOI: 10.1002/Pmic.201200371 |
0.31 |
|
2012 |
Pintzas A, Zhivotovsky B, Workman P, Clarke PA, Linardopoulos S, Martinou JC, Lacal JC, Robine S, Nasioulas G, Andera L. Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium. Cancer Biology & Therapy. 13: 458-66. PMID 22406997 DOI: 10.4161/Cbt.19600 |
0.333 |
|
2011 |
Gallego-Ortega D, Pulgar TGd, Valdés-Mora F, Cebrián A, Lacal JC. Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions. Advances in Enzyme Regulation. 51: 183-194. PMID 21035492 DOI: 10.1016/J.Advenzreg.2010.09.010 |
0.375 |
|
2011 |
Cueva Adl, Molina ARd, Ramos MA, Cebrian A, Pulgar TGd, Lacal JC. Abstract 3514: Combination of 5-FU with ChoKα inhibitors as a new alternative therapy in colorectal cancer Cancer Research. 71: 3514-3514. DOI: 10.1158/1538-7445.Am2011-3514 |
0.391 |
|
2011 |
Sanchez-Lopez E, Menchén L, Seco E, Pulgar TGd, Lacal JC, Cebrián A. Abstract 2644: Inhibition of choline kinase increases endoplasmic reticulum stress proteins Cancer Research. 71: 2644-2644. DOI: 10.1158/1538-7445.Am2011-2644 |
0.41 |
|
2010 |
Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, RamÃrez de Molina A, Lacal JC, Workman P, Leach MO. The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. Cancer Research. 70: 5507-17. PMID 20551061 DOI: 10.1158/0008-5472.Can-09-4476 |
0.359 |
|
2010 |
Álvarez-Miranda M, Becerra M, Tébar LA, Molina ARd, Pulgar TGd, Andera L, Lacal JC. Abstract 1545: Combinatorial efficacy of TRAIL and MN58b against colon cancer to overcome TRAIL resistance Cancer Research. 70: 1545-1545. DOI: 10.1158/1538-7445.Am10-1545 |
0.371 |
|
2009 |
Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Molecular Cancer. 8: 131. PMID 20042122 DOI: 10.1186/1476-4598-8-131 |
0.384 |
|
2009 |
Gallego-Ortega D, Molina ARd, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. Differential role of human choline kinase α and β enzymes in lipid metabolism: Implications in cancer onset and treatment Plos One. 4. PMID 19915674 DOI: 10.1371/Journal.Pone.0007819 |
0.428 |
|
2009 |
Hernando E, Sarmentero-Estrada J, Koppie T, Belda-Iniesta C, Ramírez de Molina V, Cejas P, Ozu C, Le C, Sánchez JJ, González-Barón M, Koutcher J, Cordón-Cardó C, Bochner BH, Lacal JC, Ramírez de Molina A. A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas. Oncogene. 28: 2425-35. PMID 19448670 DOI: 10.1038/Onc.2009.91 |
0.374 |
|
2008 |
Bañez-Coronel M, RamÃrez de Molina A, RodrÃguez-González A, Sarmentero J, Ramos MA, GarcÃa-Cabezas MA, GarcÃa-Oroz L, Lacal JC. Choline kinase alpha depletion selectively kills tumoral cells. Current Cancer Drug Targets. 8: 709-19. PMID 19075594 DOI: 10.2174/156800908786733432 |
0.408 |
|
2008 |
Molina ARd, Gallego-Ortega D, Sarmentero-Estrada J, Lagares D, Pulgar TGd, Bandrés E, García-Foncillas J, Lacal JC. Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy. The International Journal of Biochemistry & Cell Biology. 40: 1753-1763. PMID 18296102 DOI: 10.1016/J.Biocel.2008.01.013 |
0.394 |
|
2008 |
Espina C, Céspedes MV, GarcÃa-Cabezas MA, Gómez del Pulgar MT, Boluda A, Oroz LG, Benitah SA, Cejas P, Nistal M, Mangues R, Lacal JC. A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells. The American Journal of Pathology. 172: 156-66. PMID 18165265 DOI: 10.2353/Ajpath.2008.070561 |
0.364 |
|
2008 |
Pulgar TGd, Valdés-Mora F, Bandrés E, Pérez-Palacios R, Espina C, Cejas P, García-Cabezas MA, Nistal M, Casado E, González-Barón M, García-Foncillas J, Lacal JC. Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism International Journal of Oncology. 33: 185-193. DOI: 10.3892/Ijo.33.1.185 |
0.352 |
|
2007 |
RamÃrez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C, Tarón M, RamÃrez de Molina V, Cejas P, Skrzypski M, Gallego-Ortega D, de Castro J, Casado E, GarcÃa-Cabezas MA, Sánchez JJ, Nistal M, Rosell R, González-Barón M, ... Lacal JC, et al. Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. The Lancet. Oncology. 8: 889-97. PMID 17851129 DOI: 10.1016/S1470-2045(07)70279-6 |
0.317 |
|
2007 |
Pulgar TGd, Bandrés E, Espina C, Valdés-Mora F, Pérez-Palacios R, García-Amigot F, García-Foncillas J, Lacal JC. Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer. The International Journal of Biochemistry & Cell Biology. 39: 2289-2302. PMID 17766170 DOI: 10.1016/J.Biocel.2007.06.014 |
0.362 |
|
2007 |
Céspedes MV, Espina C, GarcÃa-Cabezas MA, Trias M, Boluda A, Gómez del Pulgar MT, Sancho FJ, Nistal M, Lacal JC, Mangues R. Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites. The American Journal of Pathology. 170: 1077-85. PMID 17322390 DOI: 10.2353/Ajpath.2007.060773 |
0.314 |
|
2006 |
Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Research. 66: 427-34. PMID 16397258 DOI: 10.1158/0008-5472.Can-05-1338 |
0.39 |
|
2006 |
Gallego-Ortega D, Molina ARD, Gutierrez R, Ramos MA, Sarmentero J, Cejas P, Nistal M, Barón MG, Lacal JC. Generation and characterization of monoclonal antibodies against choline kinase α and their potential use as diagnostic tools in cancer International Journal of Oncology. 29: 335-340. DOI: 10.3892/Ijo.29.2.335 |
0.345 |
|
2005 |
Molina ARd, Gallego-Ortega D, Sarmentero J, Bañez-Coronel M, Martín-Cantalejo Y, Lacal JC. Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis. Cancer Research. 65: 5647-5653. PMID 15994937 DOI: 10.1158/0008-5472.Can-04-4416 |
0.373 |
|
2005 |
Pulgar TGd, Benitah SA, Valerón PF, Espina C, Lacal JC. Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays. 27: 602-613. PMID 15892119 DOI: 10.1002/Bies.20238 |
0.364 |
|
2005 |
Sánchez-MartÃn R, Campos JM, Conejo-GarcÃa A, Cruz-López O, Báñez-Coronel M, RodrÃguez-González A, Gallo MA, Lacal JC, Espinosa A. Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line. Journal of Medicinal Chemistry. 48: 3354-63. PMID 15857141 DOI: 10.1021/Jm049061O |
0.306 |
|
2005 |
Rodríguez-González A, Molina ARD, Bañez-Coronel M, Megias D, Lacal JC. Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism. International Journal of Oncology. 26: 999-1008. DOI: 10.3892/Ijo.26.4.999 |
0.393 |
|
2004 |
Benitah SA, Valerón PF, van Aelst L, Marshall CJ, Lacal JC. Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochimica Et Biophysica Acta. 1705: 121-32. PMID 15588766 DOI: 10.1016/J.Bbcan.2004.10.002 |
0.383 |
|
2004 |
Conejo-GarcÃa A, Báñez-Coronel M, Sánchez-MartÃn RM, RodrÃguez-González A, Ramos A, RamÃrez de Molina A, Espinosa A, Gallo MA, Campos JM, Lacal JC. Influence of the linker in bispyridium compounds on the inhibition of human choline kinase. Journal of Medicinal Chemistry. 47: 5433-40. PMID 15481981 DOI: 10.1021/Jm0496537 |
0.335 |
|
2004 |
Rodríguez-González A, Molina ARd, Fernández F, Lacal JC. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene. 23: 8247-8259. PMID 15378008 DOI: 10.1038/Sj.Onc.1208045 |
0.398 |
|
2004 |
Molina ARd, Báñez-Coronel M, Gutiérrez R, Rodríguez-González A, Olmeda D, Megías D, Lacal JC. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Research. 64: 6732-6739. PMID 15374991 DOI: 10.1158/0008-5472.Can-04-0489 |
0.337 |
|
2004 |
Aznar S, Fernández-Valerón P, Espina C, Lacal JC. Rho GTPases: potential candidates for anticancer therapy. Cancer Letters. 206: 181-191. PMID 15013523 DOI: 10.1016/J.Canlet.2003.08.035 |
0.392 |
|
2004 |
Molina ARd, Rodrı́guez-González A, Lacal JC. From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design Cancer Letters. 206: 137-148. PMID 15013519 DOI: 10.1016/J.Canlet.2003.08.031 |
0.373 |
|
2004 |
Lacal JC. Anticancer research: a few hints for discovery of new targets. Cancer Letters. 206: 125-127. PMID 15013517 DOI: 10.1016/J.Canlet.2003.09.014 |
0.352 |
|
2004 |
Báñez-Coronel M, Rodríguez-González A, Martín-Cantalejo Y, Sáez B, Soto J, Villa MJ, Braña MF, Lacal JC. A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis. International Journal of Oncology. 25: 1097-1103. DOI: 10.3892/Ijo.25.4.1097 |
0.342 |
|
2003 |
Rodríguez-González A, Molina ARd, Fernández F, Ramos MA, Núñez MdC, Campos J, Lacal JC. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene. 22: 8803-8812. PMID 14654777 DOI: 10.1038/Sj.Onc.1207062 |
0.422 |
|
2003 |
Benitah SA, Valerón PF, Lacal JC. ROCK and Nuclear Factor-κB–dependent Activation of Cyclooxygenase-2 by Rho GTPases: Effects on Tumor Growth and Therapeutic Consequences Molecular Biology of the Cell. 14: 3041-3054. PMID 12857884 DOI: 10.1091/Mbc.E03-01-0016 |
0.366 |
|
2003 |
Conejo-GarcÃa A, Campos J, Sánchez RM, RodrÃguez-González A, Lacal JC, Gallo MA, Espinosa A. Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides. European Journal of Medicinal Chemistry. 38: 109-16. PMID 12593921 DOI: 10.1002/CHIN.200328158 |
0.335 |
|
2003 |
Benitah SA, Valerón PF, Rui H, Lacal JC. STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. Molecular Biology of the Cell. 14: 40-53. PMID 12529425 DOI: 10.1091/Mbc.E02-08-0454 |
0.385 |
|
2003 |
Lucas L, Penalva V, Ramírez de Molina A, Del Peso L, Lacal JC. Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1. International Journal of Oncology. 21: 477-85. PMID 12168089 |
0.301 |
|
2003 |
Benitah SA, Espina C, Valerón PF, Lacal JC. Rho GTPases in human carcinogenesis: a tale of excess Clinical & Translational Oncology. 5: 70-78. DOI: 10.1007/Bf02728199 |
0.384 |
|
2002 |
Sánchez-Pérez I, Benitah SA, Martínez-Gomariz M, Lacal JC, Perona R. Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Molecular Biology of the Cell. 13: 2933-45. PMID 12181357 DOI: 10.1091/Mbc.E02-01-0022 |
0.361 |
|
2002 |
Molina ARd, Rodrı́guez-González A, Gutiérrez R, Martı́nez-Piñeiro L, Sánchez JJ, Bonilla F, Rosell R, Lacal JC. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers Biochemical and Biophysical Research Communications. 296: 580-583. PMID 12176020 DOI: 10.1016/S0006-291X(02)00920-8 |
0.394 |
|
2002 |
Molina ARd, Gutiérrez R, Ramos MA, Silva JM, Silva J, Bonilla F, Sánchez JJ, Lacal JC. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene. 21: 4317-4322. PMID 12082619 DOI: 10.1038/Sj.Onc.1205556 |
0.331 |
|
2002 |
Molina ARd, Penalva V, Lucas L, Lacal JC. Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Oncogene. 21: 937-946. PMID 11840339 DOI: 10.1038/Sj.Onc.1205144 |
0.409 |
|
2002 |
Lucas L, Penalva V, Molina ARd, Peso LD, Lacal JC. Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1. International Journal of Oncology. 21: 477-485. DOI: 10.3892/Ijo.21.3.477 |
0.411 |
|
2001 |
Aznar S, Valerón PF, del Rincon SV, Pérez LF, Perona R, Lacal JC. Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Molecular Biology of the Cell. 12: 3282-94. PMID 11598209 DOI: 10.1091/Mbc.12.10.3282 |
0.371 |
|
2001 |
Aznar S, Lacal JC. Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. Progress in Nucleic Acid Research and Molecular Biology. 67: 193-234. PMID 11525383 DOI: 10.1016/S0079-6603(01)67029-6 |
0.395 |
|
2001 |
Molina ARd, Rodríguez-González A, Penalva V, Lucas L, Lacal JC. Inhibition of ChoK Is an Efficient Antitumor Strategy for Harvey-, Kirsten-, and N-ras-Transformed Cells Biochemical and Biophysical Research Communications. 285: 873-879. PMID 11467831 DOI: 10.1006/Bbrc.2001.5250 |
0.366 |
|
2001 |
Lucas L, Hernández-Alcoceba R, Penalva V, Lacal JC. Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity. Oncogene. 20: 1110-1117. PMID 11314048 DOI: 10.1038/Sj.Onc.1204216 |
0.387 |
|
2001 |
Aznar S, Lacal JC. Rho signals to cell growth and apoptosis. Cancer Letters. 165: 1-10. PMID 11248412 DOI: 10.1016/S0304-3835(01)00412-8 |
0.4 |
|
2001 |
Molina ARd, Rodriguez-Gonzalez A, Lacal JC. Targeting new anticancer drugs within signalling pathways regulated by the Ras GTPase superfamily (Review) International Journal of Oncology. 19: 5-17. DOI: 10.3892/Ijo.19.1.5 |
0.402 |
|
2001 |
Rodriguez-González A, Fernández F, Campos J, Espinosa A, Lacal JC. Differential effects of choline kinase inhibitors in tumoral and primary human cells European Journal of Cancer. 37. DOI: 10.1016/S0959-8049(01)80768-1 |
0.36 |
|
2000 |
Embade N, Valerón PF, Aznar S, López-Collazo E, Lacal JC. Apoptosis Induced by Rac GTPase Correlates with Induction of FasL and Ceramides Production Molecular Biology of the Cell. 11: 4347-4358. PMID 11102528 DOI: 10.1091/Mbc.11.12.4347 |
0.377 |
|
2000 |
Hernández-Alcoceba R, Peso Ld, Lacal JC. The Ras family of GTPases in cancer cell invasion. Cellular and Molecular Life Sciences. 57: 65-76. PMID 10949581 DOI: 10.1007/S000180050499 |
0.4 |
|
2000 |
Lucas L, Peso LD, Rodriguez P, Penalva V, Lacal JC. Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor. Oncogene. 19: 431-437. PMID 10656691 DOI: 10.1038/Sj.Onc.1203323 |
0.312 |
|
1999 |
Montaner S, Perona R, Saniger L, Lacal JC. Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors. The Journal of Biological Chemistry. 274: 8506-15. PMID 10085083 DOI: 10.1074/Jbc.274.13.8506 |
0.31 |
|
1999 |
Lacal JC. In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery European Journal of Cancer. 35. DOI: 10.1016/S0959-8049(99)80913-7 |
0.324 |
|
1998 |
Esteve P, Embade N, Perona R, Jiménez B, del Peso L, León J, Arends M, Miki T, Lacal JC. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. 17: 1855-69. PMID 9778052 DOI: 10.1038/Sj.Onc.1202082 |
0.406 |
|
1998 |
Montaner S, Perona R, Saniger L, Lacal JC. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. The Journal of Biological Chemistry. 273: 12779-85. PMID 9582304 DOI: 10.1074/Jbc.273.21.12779 |
0.348 |
|
1998 |
Carnero A, Lacal JC. Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway Febs Letters. 422: 155-159. PMID 9489996 DOI: 10.1016/S0014-5793(97)01619-0 |
0.377 |
|
1997 |
Peso LD, Hernandez-Alcoceba R, Embade N, Carnero A, Esteve P, Paje C, Lacal JC. Rho proteins induce metastatic properties in vivo. Oncogene. 15: 3047-3057. PMID 9444953 DOI: 10.1038/Sj.Onc.1201499 |
0.391 |
|
1997 |
Donato AD, Lacal JC, Duca MD, Giampuzzi M, Ghiggeri G, Gusmano R. Micro-injection of recombinant lysyl oxidase blocks oncogenic p21-Ha-Ras and progesterone effects on Xenopus laevis oocyte maturation Febs Letters. 419: 63-68. PMID 9426221 DOI: 10.1016/S0014-5793(97)01420-8 |
0.394 |
|
1997 |
Hernández-Alcoceba R, Saniger L, Campos J, Núñez MC, Khaless F, Gallo MA, Espinosa A, Lacal JC. Choline kinase inhibitors as a novel approach for antiproliferative drug design. Oncogene. 15: 2289-301. PMID 9393874 DOI: 10.1038/sj.onc.1201414 |
0.331 |
|
1997 |
Lacal JC. Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling Febs Letters. 410: 73-77. PMID 9247126 DOI: 10.1016/S0014-5793(97)00444-4 |
0.36 |
|
1997 |
Peso Ld, Lucas L, Esteve P, Lacal JC. Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways. Biochemical Journal. 322: 519-528. PMID 9065772 DOI: 10.1042/Bj3220519 |
0.408 |
|
1997 |
Perona R, Montaner S, Saniger L, Sánchez-Pérez I, Bravo R, Lacal JC. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes & Development. 11: 463-75. PMID 9042860 DOI: 10.1101/Gad.11.4.463 |
0.393 |
|
1997 |
Esteve P, Embade N, Perona R, Suárez C, Jiménez B, León J, Peso L, Lacal JC. Involvement of Rho proteins in regulation of transformation and apoptosls European Journal of Cancer. 33. DOI: 10.1016/S0959-8049(97)84579-0 |
0.304 |
|
1996 |
Peso Ld, Hernández R, Esteve P, Lacal JC. Activation of phospholipase D by ras proteins is independent of protein kinase C. Journal of Cellular Biochemistry. 61: 599-608. PMID 8806084 DOI: 10.1002/(Sici)1097-4644(19960616)61:4<599::Aid-Jcb14>3.0.Co;2-B |
0.387 |
|
1995 |
Sanchez-Prieto R, Vargas JA, Carnero A, Marchetti E, Romero J, Durantez A, Lacal JC, Ramon y Cajal S. Modulation of cellular chemoresistance in keratinocytes by activation of different oncogenes. International Journal of Cancer. Journal International Du Cancer. 60: 235-43. PMID 7829222 DOI: 10.1002/Ijc.2910600218 |
0.376 |
|
1995 |
Carnero A, Lacal JC. Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study. Molecular and Cellular Biology. 15: 1094-1101. PMID 7823925 DOI: 10.1128/Mcb.15.2.1094 |
0.414 |
|
1995 |
Jiménez B, del Peso L, Montaner S, Esteve P, Lacal JC. Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. Journal of Cellular Biochemistry. 57: 141-9. PMID 7721953 DOI: 10.1002/Jcb.240570114 |
0.363 |
|
1994 |
Carnero A, Dolfi F, Lacal JC. ras-p21 activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis oocytes. Journal of Cellular Biochemistry. 54: 478-486. PMID 8014197 DOI: 10.1002/Jcb.240540415 |
0.365 |
|
1994 |
Carnero A, Jiménez B, Lacal JC. Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways Journal of Cellular Biochemistry. 55: 465-476. PMID 7962177 DOI: 10.1002/Jcb.240550406 |
0.395 |
|
1993 |
Dolfi F, Carnero A, Ramponi G, Lacal JC. Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras-p21. Febs Letters. 326: 167-170. PMID 8391991 DOI: 10.1016/0014-5793(93)81784-W |
0.377 |
|
1993 |
Carnero A, Lacal JC. Phospholipase-induced maturation of Xenopus laevis oocytes: mitogenic activity of generated metabolites. Journal of Cellular Biochemistry. 52: 440-448. PMID 8227176 DOI: 10.1002/Jcb.240520408 |
0.375 |
|
1990 |
Lacal JC, Cuadrado A, Jones JE, Trotta R, Burstein DE, Thomson T, Pellicer A. Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells. Molecular and Cellular Biology. 10: 2983-90. PMID 2188105 DOI: 10.1128/mcb.10.6.2983-2990.1990 |
0.415 |
|
1989 |
Srivastava SK, Donato AD, Lacal JC. H-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction Molecular and Cellular Biology. 9: 1779-1783. PMID 2471068 DOI: 10.1128/Mcb.9.4.1779 |
0.361 |
|
1989 |
Lapetina EG, Lacal JC, Reep BR, Vedia LMy. A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proceedings of the National Academy of Sciences of the United States of America. 86: 3131-3134. PMID 2470091 DOI: 10.1073/Pnas.86.9.3131 |
0.325 |
|
1988 |
Valencia A, Serrano L, Caballero R, Anderson PS, Lacal JC. Conformational alterations detected by circular dichroism induced in the normal ras p21 protein by activating point mutations at position 12, 59, or 61. European Journal of Biochemistry / Febs. 174: 621-7. PMID 3292238 DOI: 10.1111/J.1432-1033.1988.Tb14143.X |
0.337 |
|
1987 |
Lacal JC, Aaronson SA. Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide. Molecular and Cellular Biology. 6: 4214-20. PMID 3540608 DOI: 10.1128/Mcb.6.12.4214 |
0.312 |
|
1987 |
Jeng AY, Srivastava SK, Lacal JC, Blumberg PM. Phosphorylation of ras oncogene product by protein kinase C. Biochemical and Biophysical Research Communications. 145: 782-8. PMID 3496094 DOI: 10.1016/0006-291X(87)91033-3 |
0.358 |
|
1987 |
Lacal JC, Fleming TP, Warren BS, Blumberg PM, Aaronson SA. Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product Molecular and Cellular Biology. 7: 4146-4149. PMID 3323889 DOI: 10.1128/Mcb.7.11.4146 |
0.376 |
|
1987 |
Lacal JC, Moscat J, Aaronson SA. Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature. 330: 269-72. PMID 3313065 DOI: 10.1038/330269A0 |
0.405 |
|
1987 |
Hagag N, Lacal JC, Graber M, Aaronson S, Viola MV. Microinjection of ras p21 induces a rapid rise in intracellular pH. Molecular and Cellular Biology. 7: 1984-1988. PMID 3037340 DOI: 10.1128/Mcb.7.5.1984 |
0.31 |
|
1987 |
Lacal JC, de la Peña P, Moscat J, Garcia-Barreno P, Anderson PS, Aaronson SA. Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21. Science (New York, N.Y.). 238: 533-6. PMID 2821623 DOI: 10.1126/Science.2821623 |
0.366 |
|
1987 |
Lacal JC, Aaronson SA. Monoclonal antibody Y13-259 recognizes an epitope of the p21 ras molecule not directly involved in the GTP-binding activity of the protein. Molecular and Cellular Biology. 6: 1002-9. PMID 2431273 DOI: 10.1128/Mcb.6.4.1002 |
0.311 |
|
1986 |
Lacal JC, Srivastava SK, Anderson PS, Aaronson SA. Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells. Cell. 44: 609-17. PMID 3004741 DOI: 10.1016/0092-8674(86)90270-9 |
0.362 |
|
1986 |
Lacal JC, Aaronson SA. ras p21 deletion mutants and monoclonal antibodies as tools for localization of regions relevant to p21 function Proceedings of the National Academy of Sciences of the United States of America. 83: 5400-5404. PMID 2426696 DOI: 10.1073/Pnas.83.15.5400 |
0.311 |
|
1986 |
Lacal J, Anderson P, Aaronson S. Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities. The Embo Journal. 5: 679-687. DOI: 10.1002/J.1460-2075.1986.Tb04267.X |
0.365 |
|
1985 |
Alarcón B, Lacal JC, Fernández-Sousa JM, Carrasco L. Screening for new compounds with antiherpes activity. Antiviral Research. 4: 231-44. PMID 6517562 DOI: 10.1016/0166-3542(84)90029-9 |
0.485 |
|
1985 |
Srivastava SK, Lacal JC, Reynolds SH, Aaronson SA. Antibody of predetermined specificity to a carboxy-terminal region of H-ras gene products inhibits their guanine nucleotide-binding function. Molecular and Cellular Biology. 5: 3316-9. PMID 3915772 DOI: 10.1128/Mcb.5.11.3316 |
0.33 |
|
1984 |
Carrasco L, Lacal JC. Permeabilization of cells during animal virus infection. Pharmacology & Therapeutics. 23: 109-45. PMID 6318237 DOI: 10.1016/0163-7258(83)90028-1 |
0.479 |
|
1984 |
Lacal JC, Santos E, Notario V, Barbacid M, Yamazaki S, Kung H, Seamans C, McAndrew S, Crowl R. Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proceedings of the National Academy of Sciences of the United States of America. 81: 5305-9. PMID 6089191 DOI: 10.1073/Pnas.81.17.5305 |
0.325 |
|
1983 |
Lacal JC, Carrasco L. Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells. Antimicrobial Agents and Chemotherapy. 24: 273-5. PMID 6314888 DOI: 10.1128/AAC.24.2.273 |
0.445 |
|
1983 |
Lacal JC, Carrasco L. Modification of membrane permeability in poliovirus-infected HeLa cells: effect of guanidine. The Journal of General Virology. 787-93. PMID 6300301 DOI: 10.1099/0022-1317-64-4-787 |
0.488 |
|
1983 |
Lacal JC, Carrasco L. Relationship between membrane integrity and the inhibition of host translation in virus-infected mammalian cells. Comparative studies between encephalomyocarditis virus and poliovirus. European Journal of Biochemistry. 127: 359-66. PMID 6291943 DOI: 10.1111/J.1432-1033.1982.Tb06880.X |
0.517 |
|
1980 |
Lacal JC, Vázquez D, Fernandez-Sousa JM, Carrasco L. Antibiotics that specifically block translation in virus-infected cells. The Journal of Antibiotics. 33: 441-6. PMID 6251018 DOI: 10.7164/Antibiotics.33.441 |
0.631 |
|
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