Michael Rynkiewicz - Publications

Affiliations: 
2015- Physiology & Biophysics Boston University, Boston, MA, United States 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lehman W, Pavadai E, Rynkiewicz MJ. C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state. Biochemical and Biophysical Research Communications. 551: 27-32. PMID 33714756 DOI: 10.1016/j.bbrc.2021.03.010  1
2020 Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end. The Journal of Biological Chemistry. PMID 33020181 DOI: 10.1074/jbc.RA120.014713  1
2020 Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal. PMID 32730789 DOI: 10.1016/J.Bpj.2020.07.006  1
2020 Pavadai E, Lehman W, Rynkiewicz MJ. Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophysical Journal. 119: 75-86. PMID 32521240 DOI: 10.1016/J.Bpj.2020.05.017  1
2020 Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nature Communications. 11: 2417. PMID 32415060 DOI: 10.1038/S41467-020-15922-5  1
2020 Pavadai E, Rynkiewicz MJ, Lehman W. A Tropomyosin Cable Model on Thin-Filaments Deduced by Protein-Protein Docking Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3205  1
2020 Rynkiewicz MJ, Lehman W. Molecular Dynamics Simulations of Alpha-Beta-Tropomyosin Show Conformational Properties of Heterodimeric Tropomyosin Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1598  1
2019 Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophysical Journal. PMID 31882250 DOI: 10.1016/J.Bpj.2019.11.3396  1
2019 Pavadai E, Rynkiewicz MJ, Ghosh A, Lehman W. Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. Biophysical Journal. PMID 31864661 DOI: 10.1016/J.Bpj.2019.11.3393  1
2019 van Eijk M, Hillaire MLB, Rimmelzwaan GF, Rynkiewicz MJ, White MR, Hartshorn KL, Hessing M, Koolmees PA, Tersteeg MH, van Es MH, Meijerhof T, Huckriede A, Haagsman HP. Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain. Frontiers in Immunology. 10: 2476. PMID 31749796 DOI: 10.3389/fimmu.2019.02476  1
2019 Janco M, Rynkiewicz MJ, Li L, Hook J, Eiffe E, Ghosh A, Böcking T, Lehman WJ, Hardeman EC, Gunning PW. Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Scientific Reports. 9: 11262. PMID 31375704 DOI: 10.1038/S41598-019-47592-9  1
2019 Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophysical Journal. PMID 31130236 DOI: 10.1016/J.Bpj.2019.05.009  1
2019 Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Mayeux R, et al. Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry. Jama Network Open. 2: e191350. PMID 30924900 DOI: 10.1001/Jamanetworkopen.2019.1350  0.01
2019 Lehman W, Rynkiewicz MJ, Moore JR. A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. Journal of Muscle Research and Cell Motility. PMID 30771202 DOI: 10.1007/S10974-019-09501-5  1
2019 Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell J, Rynkiewicz MJ, Cannon-Albright L, Teerlink C, Stevens J, Corcoran C, Murcia JDG, Lopez OL, Mayeux R, et al. O3-13-01: Highly Penetrant Late-Onset Alzheimer Disease Variants In Notch3 In Ashkenazi Jews Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4696  0.01
2019 Racca AW, LaFave N, Jones S, Rynkiewicz MJ, Lehman W, Moore JR. Functional Implications of Dcm End-to-End Bond Mutation in A-Tropomyosin Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.989  1
2019 Sundar S, Rynkiewicz MJ, Lehman W, Moore JR. Cardiomyopathy Mutation at End-End Overlap of Alpha - Tropomyosin Influences Cooperative Activation and Calcium Sensitivity Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2517  1
2019 Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ. Tropomyosin Cable Formation and Its Influence on the Structural Dynamics of Tropomyosin Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.199  1
2018 Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ. Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states. The Journal of General Physiology. PMID 30442774 DOI: 10.1085/Jgp.201812188  1
2018 Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophysical Journal. PMID 30195938 DOI: 10.1016/J.Bpj.2018.08.017  1
2018 Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics. PMID 29626422 DOI: 10.1016/J.Abb.2018.04.002  1
2018 Kiani FA, Rynkiewicz MJ, Fischer S, Lehman W. Tropomyosin Translocation on F-Actin Revealed by Molecular Dynamics Simulations Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.769  1
2017 Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophysical Journal. 113: 2444-2451. PMID 29211998 DOI: 10.1016/J.Bpj.2017.10.004  1
2017 Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Reports. 20: 2612-2625. PMID 28903042 DOI: 10.1016/J.Celrep.2017.08.070  1
2017 Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop. Biochemistry. PMID 28719181 DOI: 10.1021/acs.biochem.6b01313  1
2017 Rynkiewicz M, Stehn J, Gunning P, Lehman W. Structure of the Anti-Cancer Compound TR100 Target-Sites on Tpm3.1 Tropomyosin Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.3019  1
2016 Rynkiewicz MJ, Fischer S, Lehman W. The propensity for tropomyosin twisting in the presence and absence of F-actin. Archives of Biochemistry and Biophysics. PMID 27663225 DOI: 10.1016/J.Abb.2016.09.008  1
2016 Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. PMID 27324153 DOI: 10.1021/Acs.Biochem.6B00048  1
2016 Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Structural Dynamics (Melville, N.Y.). 3: 012002. PMID 26798831 DOI: 10.1063/1.4940223  1
2016 Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly Structural Dynamics. 3. DOI: 10.1063/1.4940223  1
2016 Rynkiewicz M, Schott V, Orzechowski M, Fischer S, Lehman W. Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions? Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2805  1
2015 Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. Plos One. 10: e0133454. PMID 26308522 DOI: 10.1371/Journal.Pone.0133454  1
2015 Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. Journal of Muscle Research and Cell Motility. 36: 525-33. PMID 26286845 DOI: 10.1007/S10974-015-9419-Z  1
2014 Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33: 235-45. PMID 25171003 DOI: 10.1089/Mab.2014.0022  1
2014 Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. Plos One. 9: e99847. PMID 24968190 DOI: 10.1371/Journal.Pone.0099847  1
2014 Sharon J, Rynkiewicz MJ, Lu Z, Yang CY. Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. Immunology. 142: 1-23. PMID 24219801 DOI: 10.1111/Imm.12213  1
2013 Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA. Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation. Biochemistry. 52: 8527-38. PMID 24224757 DOI: 10.1021/Bi4010683  1
2013 Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 140: 374-89. PMID 23844703 DOI: 10.1111/Imm.12150  1
2012 Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 51: 5684-94. PMID 22747335 DOI: 10.1021/Bi201711M  1
2012 van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. The Journal of Biological Chemistry. 287: 26666-77. PMID 22685299 DOI: 10.1074/Jbc.M112.368571  1
2011 Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. The Journal of Biological Chemistry. 286: 40681-92. PMID 21965658 DOI: 10.1074/Jbc.M111.300673  1
2011 van Eijk M, Bruinsma L, Hartshorn KL, White MR, Rynkiewicz MJ, Seaton BA, Hemrika W, Romijn RA, van Balkom BW, Haagsman HP. Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses. The Journal of Biological Chemistry. 286: 20137-51. PMID 21489996 DOI: 10.1074/Jbc.M111.224469  1
2011 Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. The Journal of Biological Chemistry. 286: 757-65. PMID 21047777 DOI: 10.1074/Jbc.M110.175265  1
2010 Hartshorn KL, White MR, Rynkiewicz M, Sorensen G, Holmskov U, Head J, Crouch EC. Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L384-92. PMID 20601494 DOI: 10.1152/Ajplung.00096.2010  1
2006 Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, Rynkiewicz MJ, Gorga JC, Bibbins F, Celatka CA, Nagafuji P, Bannister TD, Meyers HV, Babine RE, Hayward NJ, et al. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants. Journal of Medicinal Chemistry. 49: 7781-91. PMID 17181160 DOI: 10.1021/Jm060978S  1
2006 Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorganic & Medicinal Chemistry Letters. 16: 5022-7. PMID 16876411 DOI: 10.1016/J.Bmcl.2006.07.043  1
2006 Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, et al. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine. Bioorganic & Medicinal Chemistry Letters. 16: 3049-54. PMID 16524727 DOI: 10.1016/J.Bmcl.2006.02.052  1
2005 Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, Christianson DW. Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry. 44: 6153-63. PMID 15835903 DOI: 10.1021/Bi050059O  1
2004 Jin L, Pluskey S, Petrella EC, Cantin SM, Gorga JC, Rynkiewicz MJ, Pandey P, Strickler JE, Babine RE, Weaver DT, Seidl KJ. The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors. The Journal of Biological Chemistry. 279: 42818-25. PMID 15292186 DOI: 10.1074/Jbc.M407096200  1
2002 Rynkiewicz MJ, Cane DE, Christianson DW. X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity. Biochemistry. 41: 1732-41. PMID 11827517 DOI: 10.1021/Bi011960G  1
2001 Rynkiewicz MJ, Cane DE, Christianson DW. Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade Proceedings of the National Academy of Sciences of the United States of America. 98: 13543-13548. PMID 11698643 DOI: 10.1073/Pnas.231313098  1
2000 Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW. Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. The Journal of Biological Chemistry. 275: 25533-9. PMID 10825154 DOI: 10.1074/Jbc.M000433200  1
1997 Rynkiewicz MJ, Seaton BA. Protein Crystallography in Medicine Advances in Molecular and Cell Biology. 22: 1-50. DOI: 10.1016/S1569-2558(08)60105-8  1
1996 Rynkiewicz MJ, Seaton BA. Chemical rescue by guanidine derivatives of an arginine-substituted site-directed mutant of Escherichia coli ornithine transcarbamylase Biochemistry. 35: 16174-16179. PMID 8973189 DOI: 10.1021/Bi961311I  1
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