| Year |
Citation |
Score |
| 2023 |
Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi T, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, ... ... Taunton J, et al. Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors. Protein Science : a Publication of the Protein Society. e4712. PMID 37354015 DOI: 10.1002/pro.4712 |
0.588 |
|
| 2023 |
Holm M, Natchiar SK, Rundlet EJ, Myasnikov AG, Watson ZL, Altman RB, Wang HY, Taunton J, Blanchard SC. mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature. PMID 37020024 DOI: 10.1038/s41586-023-05908-w |
0.545 |
|
| 2023 |
Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J. An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell. 186: 346-362.e17. PMID 36638793 DOI: 10.1016/j.cell.2022.12.025 |
0.571 |
|
| 2022 |
Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J. Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3. Nature Chemistry. PMID 36123449 DOI: 10.1038/s41557-022-01039-3 |
0.527 |
|
| 2022 |
Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J. Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nature Chemical Biology. PMID 35590003 DOI: 10.1038/s41589-022-01019-1 |
0.373 |
|
| 2021 |
Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Acs Chemical Biology. PMID 34251165 DOI: 10.1021/acschembio.1c00094 |
0.757 |
|
| 2020 |
Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, et al. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Advances. 4: 2899-2911. PMID 32589729 DOI: 10.1182/Bloodadvances.2019001346 |
0.345 |
|
| 2020 |
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Taunton J, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9 |
0.636 |
|
| 2020 |
Wan X, Yang T, Cuesta A, Pang X, Balius TE, Irwin J, Shoichet BK, Taunton J. Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. Journal of the American Chemical Society. PMID 32105459 DOI: 10.1021/Jacs.9B10377 |
0.464 |
|
| 2020 |
Cuesta A, Wan X, Burlingame AL, Taunton J. Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. Journal of the American Chemical Society. PMID 32009391 DOI: 10.1021/Jacs.9B09684 |
0.366 |
|
| 2019 |
Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, ... Taunton J, et al. Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein. Jci Insight. 4. PMID 31045573 DOI: 10.1172/Jci.Insight.124867 |
0.341 |
|
| 2019 |
Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, ... ... Taunton J, et al. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. Jci Insight. 4. PMID 30944250 DOI: 10.1172/Jci.Insight.125570 |
0.368 |
|
| 2019 |
Cuesta A, Taunton J. Lysine-Targeted Inhibitors and Chemoproteomic Probes. Annual Review of Biochemistry. PMID 30633551 DOI: 10.1146/Annurev-Biochem-061516-044805 |
0.437 |
|
| 2019 |
Meyer LK, Delgado-Martin C, Sharp PP, McMinn D, Kirk CJ, Taunton J, Hermiston ML. Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia Blood. 134: 805-805. DOI: 10.1182/Blood-2019-127537 |
0.346 |
|
| 2019 |
Lowe E, Anderl JL, Fan AR, Fang Y, Jiang J, Johnson HW, Kirk CJ, McMinn D, Muchamuel T, Rao M, Sharp PP, Taunton J, Wang J, Whang JA. Abstract 3860: Discovery and characterization of novel anti-cancer small molecule inhibitors of Sec61 Cancer Research. 79: 3860-3860. DOI: 10.1158/1538-7445.Am2019-3860 |
0.452 |
|
| 2019 |
Lowe E, Anderl JL, Fan AR, Jiang J, Johnson HW, Kirk CJ, McMinn D, Muchamuel T, Taunton J, Whang JA. Abstract 3087: KZR-8834: A novel, small molecule inhibitor of Sec61-dependent protein secretion with anti-tumor activity Cancer Research. 79: 3087-3087. DOI: 10.1158/1538-7445.Am2019-3087 |
0.39 |
|
| 2018 |
Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. PMID 29622655 DOI: 10.3324/Haematol.2017.174482 |
0.603 |
|
| 2018 |
Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. Cell Death & Disease. 9: 397. PMID 29540678 DOI: 10.1038/S41419-018-0427-Y |
0.332 |
|
| 2017 |
Roberts KG, Yang YL, Payne-Turner D, Lin W, Files JK, Dickerson K, Gu Z, Taunton J, Janke LJ, Chen T, Loh ML, Hunger SP, Mullighan CG. Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL. Blood Advances. 1: 1657-1671. PMID 29296813 DOI: 10.1182/Bloodadvances.2017011296 |
0.305 |
|
| 2017 |
Smith GA, Taunton J, Weiss A. IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Science Signaling. 10. PMID 29259099 DOI: 10.1126/Scisignal.Aan4931 |
0.612 |
|
| 2017 |
Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P. Mitogen and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α subunit expression. The Journal of Biological Chemistry. PMID 29054929 DOI: 10.1074/Jbc.M117.797845 |
0.342 |
|
| 2017 |
Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey D, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. PMID 28484265 DOI: 10.1038/Leu.2017.136 |
0.543 |
|
| 2017 |
Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. Journal of the American Chemical Society. PMID 28051857 DOI: 10.1021/Jacs.6B08536 |
0.467 |
|
| 2016 |
Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD. Regulation of B cell fate by chronic activity of the IgE B cell receptor. Elife. 5. PMID 27935477 DOI: 10.7554/Elife.21238 |
0.559 |
|
| 2016 |
Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. The Journal of Experimental Medicine. PMID 27821549 DOI: 10.1084/Jem.20160662 |
0.373 |
|
| 2016 |
Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD. Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription. Molecular Cell. 64: 347-361. PMID 27768872 DOI: 10.1016/J.Molcel.2016.09.026 |
0.613 |
|
| 2016 |
Rodríguez-Molina JB, Tseng SC, Simonett SP, Taunton J, Ansari AZ. Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization. Molecular Cell. PMID 27477907 DOI: 10.1016/J.Molcel.2016.06.036 |
0.386 |
|
| 2016 |
Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chemical Biology. 23: 561-6. PMID 27203376 DOI: 10.1016/J.Chembiol.2016.04.008 |
0.422 |
|
| 2016 |
Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science (New York, N.Y.). PMID 27056844 DOI: 10.1126/Science.Aad9964 |
0.552 |
|
| 2016 |
Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nature Chemical Biology. PMID 27018889 DOI: 10.1038/Nchembio.2056 |
0.671 |
|
| 2016 |
Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CDC. Author response: Regulation of B cell fate by chronic activity of the IgE B cell receptor Elife. DOI: 10.7554/Elife.21238.020 |
0.534 |
|
| 2016 |
Delgado-Martin C, Shimano K, Zinter MS, Wahlstrom JT, Smith GA, Taunton J, Winter SS, Roderick JE, Kelliher M, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia Blood. 128: 3963-3963. DOI: 10.1182/Blood.V128.22.3963.3963 |
0.542 |
|
| 2016 |
Lam C, Murnane M, Smith GA, Taunton J, Aftab BT, Wiita AP. Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma Blood. 128: 2098-2098. DOI: 10.1182/Blood.V128.22.2098.2098 |
0.601 |
|
| 2016 |
Su X, Ditlev J, Hui E, Banjade S, Okrut J, Taunton J, Rosen M, Vale R. Abstract A087: Phase separation of signaling molecules promotes T cell receptor signal transduction Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A087 |
0.349 |
|
| 2015 |
Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. Elife. 4. PMID 26651998 DOI: 10.7554/Elife.10222 |
0.61 |
|
| 2015 |
Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J. Allosteric N-WASP activation by an inter-SH3 domain linker in Nck. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554011 DOI: 10.1073/Pnas.1510876112 |
0.586 |
|
| 2015 |
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Taunton J, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/Nchembio1115-887C |
0.419 |
|
| 2015 |
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Taunton J, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/Nchembio.1867 |
0.4 |
|
| 2015 |
Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, ... ... Taunton J, et al. Prolonged and tunable residence time using reversible covalent kinase inhibitors. Nature Chemical Biology. 11: 525-31. PMID 26006010 DOI: 10.1038/Nchembio.1817 |
0.445 |
|
| 2015 |
London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimerman?i? P, Bonnet R, Shoichet BK, Taunton J. Erratum: Covalent docking of large libraries for the discovery of chemical probes. Nature Chemical Biology. 11: 235. PMID 25689339 DOI: 10.1038/nchembio0315-235b |
0.657 |
|
| 2015 |
Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. The Journal of Clinical Investigation. 125: 1299-310. PMID 25689261 DOI: 10.1172/Jci76453 |
0.308 |
|
| 2015 |
Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Oncogene. PMID 25619841 DOI: 10.1038/Onc.2014.455 |
0.822 |
|
| 2015 |
Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. Author response: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex Elife. DOI: 10.7554/Elife.10222.027 |
0.571 |
|
| 2015 |
Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Abstract 2635: Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum Cancer Research. 75: 2635-2635. DOI: 10.1158/1538-7445.Am2015-2635 |
0.804 |
|
| 2015 |
Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum Oncogene. DOI: 10.1016/S0959-8049(16)61463-6 |
0.785 |
|
| 2014 |
Miller RM, Taunton J. Targeting protein kinases with selective and semipromiscuous covalent inhibitors. Methods in Enzymology. 548: 93-116. PMID 25399643 DOI: 10.1016/B978-0-12-397918-6.00004-5 |
0.692 |
|
| 2014 |
London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, CimermanÄiÄ P, Bonnet R, Shoichet BK, Taunton J. Covalent docking of large libraries for the discovery of chemical probes. Nature Chemical Biology. 10: 1066-72. PMID 25344815 DOI: 10.1038/Nchembio.1666 |
0.737 |
|
| 2014 |
Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. Journal of the American Chemical Society. 136: 12624-30. PMID 25153195 DOI: 10.1021/Ja505194W |
0.734 |
|
| 2014 |
Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife. 3: e01483. PMID 24497544 DOI: 10.7554/Elife.01483 |
0.557 |
|
| 2014 |
MacKinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate Elife. 2014. DOI: 10.7554/eLife.01483 |
0.495 |
|
| 2014 |
Taunton J. Abstract SY05-02: Targeting kinases with reversible covalent fragments Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy05-02 |
0.46 |
|
| 2014 |
Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Correction to “Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis” Journal of the American Chemical Society. 136: 17690-17690. DOI: 10.1021/Ja510773C |
0.677 |
|
| 2013 |
Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, et al. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. The Journal of Biological Chemistry. 288: 32528-38. PMID 24085294 DOI: 10.1074/Jbc.M113.500561 |
0.386 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemicin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. 2013. PMID 23853713 DOI: 10.7554/Elife.00712 |
0.788 |
|
| 2013 |
Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, et al. p90 RSK2 Mediates Antianoikis Signals by both Transcription-Dependent and-Independent Mechanisms Molecular and Cellular Biology. 33: 2574-2585. PMID 23608533 DOI: 10.1128/Mcb.01677-12 |
0.42 |
|
| 2013 |
Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. Journal of the American Chemical Society. 135: 5298-301. PMID 23540679 DOI: 10.1021/Ja401221B |
0.792 |
|
| 2013 |
Paavilainen VO, Taunton J. Proteostasis modulators with discriminating taste. Chemistry & Biology. 20: 144-5. PMID 23438743 DOI: 10.1016/J.Chembiol.2013.02.002 |
0.398 |
|
| 2013 |
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, et al. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein Journal of Organic Chemistry. 9: 15-25. PMID 23400640 DOI: 10.3762/Bjoc.9.3 |
0.797 |
|
| 2013 |
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, ... Taunton J, et al. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 127: 486-99. PMID 23243209 DOI: 10.1161/Circulationaha.112.116988 |
0.768 |
|
| 2013 |
MacKinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. Author response: An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate Elife. DOI: 10.7554/Elife.01483.018 |
0.541 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. 2. DOI: 10.7554/Elife.01214 |
0.763 |
|
| 2013 |
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Author response: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. DOI: 10.7554/Elife.00712.010 |
0.759 |
|
| 2013 |
Lowe E, Maglathlin R, Lerner A, Taunton J, Kirk CJ, Arastu-Kapur S. Blocking Protein Secretion and Degradation Is a Novel Treatment Strategy For Malignant Cells With High Protein Load Blood. 122: 4439-4439. DOI: 10.1182/Blood.V122.21.4439.4439 |
0.779 |
|
| 2013 |
Jin L, Li D, Lee J, Alesi GN, Fan J, Kang H, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu T, Chen ZG, Shin DM, Khuri FR, et al. Abstract 2925: p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis. Cancer Research. 73: 2925-2925. DOI: 10.1158/1538-7445.Am2013-2925 |
0.392 |
|
| 2013 |
Li D, Jin L, Alesi G, Kim YM, Wang D, Lee BH, Taunton J, Magliocca KR, Chen ZG, Kang S. Abstract 2686: RSK2/CREB/Fascin-1 signaling is important for tumor metastasis. Cancer Research. 73: 2686-2686. DOI: 10.1158/1538-7445.Am2013-2686 |
0.351 |
|
| 2012 |
Gushwa NN, Kang S, Chen J, Taunton J. Selective targeting of distinct active site nucleophiles by irreversible Src-family kinase inhibitors Journal of the American Chemical Society. 134: 20214-20217. PMID 23190395 DOI: 10.1021/Ja310659J |
0.801 |
|
| 2012 |
Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Molecular Biology of the Cell. 23: 2712-22. PMID 22648169 DOI: 10.1091/Mbc.E12-03-0228 |
0.634 |
|
| 2012 |
Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nature Chemical Biology. 8: 471-6. PMID 22466421 DOI: 10.1038/Nchembio.925 |
0.784 |
|
| 2012 |
Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proceedings of the National Academy of Sciences of the United States of America. 109: 5277-82. PMID 22403064 DOI: 10.1073/Pnas.1114487109 |
0.324 |
|
| 2012 |
Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, et al. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circulation Research. 110: 536-50. PMID 22267842 DOI: 10.1161/Circresaha.111.254730 |
0.301 |
|
| 2012 |
Farhadian JA, O'Reilly KE, Vega-Saenz de Miera E, Ye F, Zavadil J, Taunton J, Zhang DY, Osman I. Elucidating distinct tumorigenic pathways in nodular versus superficial spreading melanoma. Journal of Clinical Oncology. 30: 8544-8544. DOI: 10.1200/Jco.2012.30.15_Suppl.8544 |
0.377 |
|
| 2012 |
Lee JS, Jin L, Li D, Kim LS, Taunton J, Chen GZ, Shin DM, Kang S. Abstract 2079: RSK2 mediates anti-anoikis signals by regulating downstream factors through both transcription -independent and -dependent manner in human cancers Cancer Research. 72: 2079-2079. DOI: 10.1158/1538-7445.Am2012-2079 |
0.41 |
|
| 2011 |
Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chemistry & Biology. 18: 1082-8. PMID 21944747 DOI: 10.1016/J.Chembiol.2011.06.015 |
0.725 |
|
| 2011 |
Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nature Methods. 8: 753-5. PMID 21765410 DOI: 10.1038/Nmeth.1653 |
0.318 |
|
| 2011 |
Henise JC, Taunton J. Irreversible Nek2 kinase inhibitors with cellular activity Journal of Medicinal Chemistry. 54: 4133-4146. PMID 21627121 DOI: 10.1021/Jm200222M |
0.81 |
|
| 2011 |
Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S. p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia Blood. 117: 6885-6894. PMID 21527514 DOI: 10.1182/Blood-2010-10-315721 |
0.367 |
|
| 2011 |
Jin L, Kim Y, Zhou W, Taunton J, Chen GZ, Shin DM, Khuri FR, Kang S. Abstract 2342: RSK2 phosphorylates and activates CREB to promote HNSCC cell invasion through upregulation of pro-metastatic MCAM and Fascin-1 Cancer Research. 71: 2342-2342. DOI: 10.1158/1538-7445.Am2011-2342 |
0.376 |
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| 2010 |
Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY. ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. The Journal of Biological Chemistry. 285: 41310-9. PMID 21044953 DOI: 10.1074/Jbc.M110.153775 |
0.363 |
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| 2010 |
Manhas N, Shi Y, Taunton J, Sun D. P90RSK activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1 Journal of Neurochemistry. 114: 1476-1486. PMID 20557427 DOI: 10.1111/J.1471-4159.2010.06868.X |
0.355 |
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| 2010 |
Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, et al. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. The Journal of Clinical Investigation. 120: 1165-77. PMID 20234090 DOI: 10.1172/Jci40582 |
0.36 |
|
| 2010 |
Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun S, Chen Z(, Khuri FR, Chen J, Shin DM, Kang S. Abstract 2367: RSK2 promotes head and neck cancer cell invasion through direct phosphorylation of Hsp27 to regulate actin filaments Cancer Research. 70: 2367-2367. DOI: 10.1158/1538-7445.Am10-2367 |
0.353 |
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| 2010 |
WOOD JL, PORCO JAJ, TAUNTON J, LEE AY, CLARDY J, SCHREIBER SL. ChemInform Abstract: Application of the Allylic Diazene Rearrangement: Synthesis of the Enediyne-Bridged Tricyclic Core of Dynemicin A. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199243262 |
0.307 |
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| 2009 |
Mackinnon AL, Taunton J. Target Identification by Diazirine Photo-Cross-linking and Click Chemistry. Current Protocols in Chemical Biology. 1: 55-73. PMID 23667793 DOI: 10.1002/9780470559277.Ch090167 |
0.604 |
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| 2009 |
Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Molecular Cell. 35: 511-22. PMID 19716794 DOI: 10.1016/J.Molcel.2009.08.002 |
0.302 |
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| 2009 |
Chaturvedi D, Cohen MS, Taunton J, Patel TB. The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. The Journal of Biological Chemistry. 284: 23670-81. PMID 19570980 DOI: 10.1074/Jbc.M109.032813 |
0.369 |
|
| 2009 |
Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, et al. Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Molecular and Cellular Biology. 29: 2105-17. PMID 19223461 DOI: 10.1128/Mcb.00998-08 |
0.375 |
|
| 2009 |
Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB. Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene. 28: 1187-96. PMID 19151764 DOI: 10.1038/Onc.2008.490 |
0.413 |
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| 2009 |
Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Molecular Cell. 33: 109-16. PMID 19150432 DOI: 10.1016/J.Molcel.2008.12.020 |
0.409 |
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| 2008 |
Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 11219-22. PMID 18642817 DOI: 10.1021/Ja8033763 |
0.615 |
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| 2008 |
Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes & Development. 22: 79-90. PMID 18172166 DOI: 10.1101/Gad.1601308 |
0.396 |
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| 2007 |
Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chemistry & Biology. 14: 1261-72. PMID 18022565 DOI: 10.1016/J.Chembiol.2007.09.011 |
0.435 |
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| 2007 |
MacKinnon AL, Garrison JL, Hegde RS, Taunton J. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. Journal of the American Chemical Society. 129: 14560-1. PMID 17983236 DOI: 10.1021/Ja076250Y |
0.749 |
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| 2007 |
Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 12: 201-14. PMID 17785202 DOI: 10.1016/J.CCR.2007.08.003 |
0.394 |
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| 2007 |
Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Molecular Biology of the Cell. 18: 3681-91. PMID 17567950 DOI: 10.1091/Mbc.E07-03-0272 |
0.617 |
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| 2007 |
Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/Jbc.M700906200 |
0.366 |
|
| 2007 |
Co C, Wong DT, Gierke S, Chang V, Taunton J. Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell. 128: 901-13. PMID 17350575 DOI: 10.1016/J.Cell.2006.12.049 |
0.563 |
|
| 2007 |
Cohen MS, Hadjivassiliou H, Taunton J. A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nature Chemical Biology. 3: 156-60. PMID 17259979 DOI: 10.1038/Nchembio859 |
0.444 |
|
| 2007 |
Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. Recruitment and activation of RSK2 by HIV-1 Tat. Plos One. 2: e151. PMID 17225856 DOI: 10.1371/Journal.Pone.0000151 |
0.35 |
|
| 2007 |
Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. Molecular Pharmacology. 71: 799-806. PMID 17142297 DOI: 10.1124/Mol.106.029900 |
0.363 |
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| 2007 |
Kang S, Dong S, Gu T, Guo A, Cohen MS, Lonial S, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. p90RSK2 as a Therapeutic Target in Treatment of FGFR3-Expressing t(4;14) Multiple Myeloma. Blood. 110: 253-253. DOI: 10.1182/Blood.V110.11.253.253 |
0.421 |
|
| 2007 |
Taunton J. Molecular Mechanism of Cotransin, a Potent and Selective Inhibitor of Protein Secretion The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A147-D |
0.353 |
|
| 2006 |
Kang SW, Rane NS, Kim SJ, Garrison JL, Taunton J, Hegde RS. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell. 127: 999-1013. PMID 17129784 DOI: 10.1016/J.Cell.2006.10.032 |
0.62 |
|
| 2006 |
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126: 727-39. PMID 16923392 DOI: 10.1016/J.Cell.2006.06.051 |
0.611 |
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| 2006 |
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/Sj.Emboj.7601166 |
0.389 |
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| 2006 |
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding H, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload (DOI:10.1016/j.cell.2006.06.051) Cell. 127: 1284. DOI: 10.1016/j.cell.2006.11.027 |
0.566 |
|
| 2005 |
Garrison JL, Kunkel EJ, Hegde RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 436: 285-9. PMID 16015336 DOI: 10.1038/Nature03821 |
0.638 |
|
| 2005 |
Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (New York, N.Y.). 308: 1318-21. PMID 15919995 DOI: 10.1126/Science1108367 |
0.396 |
|
| 2005 |
Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Molecular Cell. 17: 181-91. PMID 15664188 DOI: 10.1016/J.Molcel.2004.11.054 |
0.576 |
|
| 2003 |
Sokac AM, Co C, Taunton J, Bement W. Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs. Nature Cell Biology. 5: 727-32. PMID 12872130 DOI: 10.1038/Ncb1025 |
0.544 |
|
| 2000 |
Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. The Journal of Cell Biology. 148: 519-30. PMID 10662777 DOI: 10.1083/Jcb.148.3.519 |
0.487 |
|
| 1997 |
Taunton J. How to starve a tumor Chemistry and Biology. 4: 493-496. PMID 9263636 DOI: 10.1016/S1074-5521(97)90320-3 |
0.345 |
|
| 1996 |
Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (New York, N.Y.). 272: 408-11. PMID 8602529 DOI: 10.1126/Science.272.5260.408 |
0.466 |
|
| 1996 |
Taunton J, Collins JL, Schreiber SL. Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function Journal of the American Chemical Society. 118: 10412-10422. DOI: 10.1021/Ja9615841 |
0.475 |
|
| 1993 |
Taunton J, Wood JL, Schreiber SL. Total syntheses of di- and tri-O-methyl dynemicin A methyl esters Journal of the American Chemical Society. 115: 10378-10379. DOI: 10.1021/Ja00075A071 |
0.516 |
|
| 1992 |
Wood JL, Porco JA, Taunton J, Lee AY, Clardy J, Schreiber SL. Application of the allylic diazene rearrangement: synthesis of the enediyne-bridged tricyclic core of dynemicin A Journal of the American Chemical Society. 114: 5898-5900. DOI: 10.1021/Ja00040A085 |
0.528 |
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