| Year |
Citation |
Score |
| 2023 |
Vogt A, He Y, Lees-Miller SP. How to fix DNA breaks: new insights into the mechanism of non-homologous end joining. Biochemical Society Transactions. 51: 1789-1800. PMID 37787023 DOI: 10.1042/BST20220741 |
0.555 |
|
| 2023 |
Chen S, Vogt A, Lee L, Naila T, McKeown R, Tomkinson AE, Lees-Miller SP, He Y. Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Science Advances. 9: eadg2838. PMID 37256947 DOI: 10.1126/sciadv.adg2838 |
0.553 |
|
| 2022 |
Ciccia A, Greenberg RA, Lees-Miller SP, Nussenzweig A. A genetic roadmap to the response to genotoxic agents in human cells. Faculty Reviews. 11: 35. PMID 36532708 DOI: 10.12703/r-01-0000019 |
0.416 |
|
| 2022 |
Neizer-Ashun F, Dwivedi SKD, Dey A, Thavathiru E, Berry WL, Lees-Miller SP, Mukherjee P, Bhattacharya R. KRCC1, a modulator of the DNA damage response. Nucleic Acids Research. PMID 36243983 DOI: 10.1093/nar/gkac890 |
0.516 |
|
| 2022 |
Lee L, Yu Y, Lees-Miller SP. Purification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) from HeLa Cells. Methods in Molecular Biology (Clifton, N.J.). 2444: 227-241. PMID 35290641 DOI: 10.1007/978-1-0716-2063-2_14 |
0.577 |
|
| 2021 |
Ye Z, Shi Y, Lees-Miller SP, Tainer JA. Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy. Frontiers in Immunology. 12: 797880. PMID 34970273 DOI: 10.3389/fimmu.2021.797880 |
0.313 |
|
| 2021 |
Chen S, Lees-Miller JP, He Y, Lees-Miller SP. Structural insights into the role of DNA-PK as a master regulator in NHEJ. Genome Instability & Disease. 2: 195-210. PMID 34723130 DOI: 10.1007/s42764-021-00047-w |
0.603 |
|
| 2021 |
Walker SR, Abdelsalam R, Ghosh S, Livingstone J, Palanisamy N, Boutros PC, Yip SM, Lees-Miller SP, Bismar TA. Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease. European Urology Open Science. 29: 93-101. PMID 34337539 DOI: 10.1016/j.euros.2021.05.004 |
0.323 |
|
| 2021 |
Unfried JP, Marín-Baquero M, Rivera-Calzada Á, Razquin N, Martín-Cuevas EM, de Bragança S, Aicart-Ramos C, McCoy C, Prats-Mari L, Arribas-Bosacoma R, Lee L, Caruso S, Zucman-Rossi J, Sangro B, Williams G, ... ... Lees-Miller SP, et al. Long noncoding RNA NIHCOLE promotes ligation efficiency of DNA double-strand breaks in hepatocellular carcinoma. Cancer Research. PMID 34321241 DOI: 10.1158/0008-5472.CAN-21-0463 |
0.331 |
|
| 2021 |
Chen S, Lee L, Naila T, Fishbain S, Wang A, Tomkinson AE, Lees-Miller SP, He Y. Structural basis of long-range to short-range synaptic transition in NHEJ. Nature. PMID 33854234 DOI: 10.1038/s41586-021-03458-7 |
0.532 |
|
| 2020 |
Hepburn M, Saltzberg DJ, Lee L, Fang S, Atkinson C, Strynadka NCJ, Sali A, Lees-Miller SP, Schriemer DC. The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex. Structure (London, England : 1993). PMID 33412091 DOI: 10.1016/j.str.2020.12.006 |
0.479 |
|
| 2020 |
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, ... ... Lees-Miller SP, et al. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids Research. PMID 33045735 DOI: 10.1093/nar/gkaa784 |
0.377 |
|
| 2020 |
Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Progress in Biophysics and Molecular Biology. PMID 33035590 DOI: 10.1016/j.pbiomolbio.2020.09.010 |
0.546 |
|
| 2020 |
Hammel M, Rosenberg DJ, Bierma J, Hura GL, Lees-Miller SP, Tainer JA. Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Progress in Biophysics and Molecular Biology. PMID 32966823 DOI: 10.1016/J.Pbiomolbio.2020.09.003 |
0.594 |
|
| 2020 |
Douglas P, Ye R, Radhamani S, Cobban A, Jenkins NP, Bartlett E, Roveredo J, Kettenbach AN, Lees-Miller SP. Nocodazole-induced expression and phosphorylation of anillin and other mitotic proteins is decreased in DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-deficient cells and rescued by inhibition of the Anaphase Promoting Complex/Cyclosome (APC/C) with proTAME but not apcin. Molecular and Cellular Biology. PMID 32284347 DOI: 10.1128/Mcb.00191-19 |
0.651 |
|
| 2020 |
Jette NR, Kumar M, Radhamani S, Arthur G, Goutam S, Yip S, Kolinsky M, Williams GJ, Bose P, Lees-Miller SP. ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. Cancers. 12. PMID 32183301 DOI: 10.3390/Cancers12030687 |
0.441 |
|
| 2020 |
Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT. DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. Science Advances. 6: eaay0922. PMID 31934630 DOI: 10.1126/Sciadv.Aay0922 |
0.629 |
|
| 2019 |
Saltzberg DJ, Hepburn M, Pilla KB, Schriemer DC, Lees-Miller SP, Blundell TL, Sali A. SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange. Progress in Biophysics and Molecular Biology. PMID 31570166 DOI: 10.1016/J.Pbiomolbio.2019.09.003 |
0.319 |
|
| 2019 |
Jette NR, Radhamani S, Arthur G, Ye R, Goutam S, Bolyos A, Petersen LF, Bose P, Bebb DG, Lees-Miller SP. Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells. British Journal of Cancer. PMID 31481733 DOI: 10.1038/S41416-019-0565-8 |
0.333 |
|
| 2019 |
Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM. Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure (London, England : 1993). PMID 31402222 DOI: 10.1016/J.Str.2019.07.012 |
0.343 |
|
| 2019 |
Mojumdar A, Sorenson K, Hohl M, Toulouze M, Lees-Miller SP, Dubrana K, Petrini JHJ, Cobb JA. Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks. Cell Reports. 28: 1564-1573.e3. PMID 31390569 DOI: 10.1016/J.Celrep.2019.07.018 |
0.576 |
|
| 2018 |
Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR. Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nature Structural & Molecular Biology. PMID 29786079 DOI: 10.1038/S41594-018-0065-1 |
0.569 |
|
| 2017 |
Sorenson KS, Mahaney BL, Lees-Miller SP, Cobb JA. The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 at DNA double strand breaks. The Journal of Biological Chemistry. PMID 28679532 DOI: 10.1074/Jbc.M117.796011 |
0.569 |
|
| 2017 |
Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA. What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods in Enzymology. 592: 417-455. PMID 28668129 DOI: 10.1016/Bs.Mie.2017.04.005 |
0.492 |
|
| 2017 |
Radhakrishnan SK, Lees-Miller SP. DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Dna Repair. 57: 17-28. PMID 28641126 DOI: 10.1016/J.Dnarep.2017.06.001 |
0.629 |
|
| 2017 |
Aceytuno RD, Piett CG, Havali-Shahriari Z, Edwards RA, Rey M, Ye R, Javed F, Fang S, Mani R, Weinfeld M, Hammel M, Tainer JA, Schriemer DC, Lees-Miller SP, Glover JNM. Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Research. PMID 28453785 DOI: 10.1093/Nar/Gkx275 |
0.57 |
|
| 2017 |
Petersen LF, Klimowicz AC, Otsuka S, Elegbede AA, Petrillo SK, Williamson T, Williamson CT, Konno M, Lees-Miller SP, Hao D, Morris D, Magliocco AM, Bebb DG. Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC. Oncotarget. PMID 28418844 DOI: 10.18632/Oncotarget.16215 |
0.416 |
|
| 2017 |
Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller S, Lee KS, Moorhead GB. Recruitment of PP1 to the centrosomal scaffold protein CEP192. Biochemical and Biophysical Research Communications. PMID 28188792 DOI: 10.1016/J.Bbrc.2017.02.004 |
0.422 |
|
| 2017 |
Wang C, Jette N, Moussienko D, Bebb DG, Lees-Miller SP. ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. Translational Oncology. 10: 190-196. PMID 28182994 DOI: 10.1016/J.Tranon.2017.01.007 |
0.435 |
|
| 2017 |
Sheff JG, Hepburn M, Yu Y, Lees-Miller SP, Schriemer DC. Nanospray HX-MS configuration for structural interrogation of large protein systems. The Analyst. PMID 28154854 DOI: 10.1039/C6An02707E |
0.311 |
|
| 2017 |
Ho CK, Kornaga EN, Klimowicz AC, Enwere EK, Dean M, Bebb GD, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM. Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy. Gynecologic Oncology. PMID 28131528 DOI: 10.1016/J.Ygyno.2016.12.025 |
0.473 |
|
| 2017 |
Lees-Miller SP. Abstract IA23: Using PARP inhibitors to target ATM-deficient cancers Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia23 |
0.417 |
|
| 2017 |
Arjumand W, Jette N, McIntyre J, Ghatage P, Doll CM, Lees-Miller SP. Abstract 3149: Identification of genes associated with the cisplatin resistance in cervical cancer cells expressing E545K mutation Cancer Research. 77: 3149-3149. DOI: 10.1158/1538-7445.Am2017-3149 |
0.31 |
|
| 2017 |
Aceytuno D, Piett C, Havali-Shahriari Z, Edwards R, Rey M, Mani R, Fang S, Hammel M, Weinfeld M, Tainer J, Schriemer D, Lees-Miller S, Glover J. Clinical dysregulation of DNA repair by the polynucleotide kinase/phosphatase-XRCC4-DNA ligase IV in neurological disease Annals of Oncology. 28: v17. DOI: 10.1093/Annonc/Mdx361.058 |
0.597 |
|
| 2016 |
Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA. An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. The Journal of Biological Chemistry. PMID 27875301 DOI: 10.1074/Jbc.M116.751867 |
0.578 |
|
| 2016 |
Arjumand W, Merry CD, Wang C, Saba E, McIntyre JB, Fang S, Kornaga E, Ghatage P, Doll CM, Lees-Miller SP. Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells. Oncotarget. PMID 27489350 DOI: 10.18632/Oncotarget.10955 |
0.36 |
|
| 2016 |
Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S. Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. PMID 27303920 DOI: 10.18632/Oncotarget.9914 |
0.565 |
|
| 2016 |
Lees-Miller SP, Beattie TL, Tainer JA. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nature Structural & Molecular Biology. 23: 509-10. PMID 27273637 DOI: 10.1038/Nsmb.3240 |
0.507 |
|
| 2015 |
Lees-Miller SP. Fumarate in DNA repair. Nature Cell Biology. 17: 1096-7. PMID 26316455 DOI: 10.1038/Ncb3232 |
0.548 |
|
| 2015 |
Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP. Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis. Molecular and Cellular Biology. 35: 2699-713. PMID 25986610 DOI: 10.1128/MCB.01312-14 |
0.579 |
|
| 2015 |
Yang H, Matsumoto Y, Trujillo KM, Lees-Miller SP, Osley MA, Tomkinson AE. Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining. Dna Repair. 31: 1-10. PMID 25942368 DOI: 10.1016/J.Dnarep.2015.04.003 |
0.555 |
|
| 2015 |
Feng X, Li H, Dean M, Wilson HE, Kornaga E, Enwere EK, Tang P, Paterson A, Lees-Miller SP, Magliocco AM, Bebb G. Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer. Breast Cancer Research : Bcr. 17: 65. PMID 25935535 DOI: 10.1186/s13058-015-0575-2 |
0.337 |
|
| 2015 |
Jette N, Lees-Miller SP. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Progress in Biophysics and Molecular Biology. 117: 194-205. PMID 25550082 DOI: 10.1016/j.pbiomolbio.2014.12.003 |
0.598 |
|
| 2015 |
Wani A, Merry C, Wang C, Fang S, Kornaga E, Mcintyre J, Ghatage P, KöBEL M, Doll CM, Lees-Miller SP. Abstract A119: Investigating PIK3CA mutational status on cisplatin and radiation sensitivity in cervical cancer cell lines: Implications for PI3K inhibitor therapy Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A119 |
0.349 |
|
| 2015 |
Bebb G, Elegbede A, Petersen L, Williamson C, Lees-Miller S. P6.10Identifying ATMic non-small cell lung cancer cell lines: Implications for designing clinical trials Annals of Oncology. 26. DOI: 10.1093/Annonc/Mdv095.7 |
0.358 |
|
| 2014 |
Lees-Miller SP. DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4. Plos Genetics. 10: e1004598. PMID 25165869 DOI: 10.1371/Journal.Pgen.1004598 |
0.632 |
|
| 2014 |
Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP. Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports. 34. PMID 24844881 DOI: 10.1042/Bsr20140051 |
0.595 |
|
| 2014 |
Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K. Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Molecular and Cellular Biology. 34: 2162-75. PMID 24687855 DOI: 10.1128/Mcb.01554-13 |
0.591 |
|
| 2014 |
Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA. Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. Dna Repair. 17: 110-20. PMID 24656613 DOI: 10.1016/J.Dnarep.2014.02.009 |
0.622 |
|
| 2014 |
Radhakrishnan SK, Jette N, Lees-Miller SP. Non-homologous end joining: emerging themes and unanswered questions. Dna Repair. 17: 2-8. PMID 24582502 DOI: 10.1016/J.Dnarep.2014.01.009 |
0.554 |
|
| 2014 |
Mahaney BL, Lees-Miller SP, Cobb JA. The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining. Dna Repair. 14: 9-16. PMID 24369855 DOI: 10.1016/J.Dnarep.2013.12.002 |
0.473 |
|
| 2014 |
Ho CK, Kornaga E, Klimowicz A, Dean M, Bebb G, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM. Expression of DNA Damage Response Proteins in Cervical Cancer Patients Treated With Radical Chemoradiation Therapy International Journal of Radiation Oncology Biology Physics. 90. DOI: 10.1016/J.Ijrobp.2014.05.490 |
0.459 |
|
| 2013 |
Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Molecular and Cellular Biology. 33: 3568-79. PMID 23836881 DOI: 10.1128/Mcb.00308-13 |
0.555 |
|
| 2013 |
Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP. XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 31-41. PMID 23442139 DOI: 10.1139/Bcb-2012-0058 |
0.597 |
|
| 2013 |
Wang C, Lees-Miller SP. Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. International Journal of Radiation Oncology, Biology, Physics. 86: 440-9. PMID 23433795 DOI: 10.1016/J.Ijrobp.2013.01.011 |
0.557 |
|
| 2013 |
Radhakrishnan SK, Bebb DG, Lees-Miller SP. Targeting ataxia-telangiectasia mutated deficient malignancies with poly ADP ribose polymerase inhibitors Translational Cancer Research. 2: 155-162. DOI: 10.21037/1123 |
0.54 |
|
| 2012 |
Bebb DG, Lees-Miller SP. Predicting PARP inhibitor sensitivity and resistance. Cell Cycle (Georgetown, Tex.). 11: 4110. PMID 23099922 DOI: 10.4161/Cc.22604 |
0.499 |
|
| 2012 |
Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. The Journal of Biological Chemistry. 287: 42206-22. PMID 23045526 DOI: 10.1074/Jbc.M112.385674 |
0.602 |
|
| 2012 |
Williamson CT, Kubota E, Hamill JD, Klimowicz A, Ye R, Muzik H, Dean M, Tu L, Gilley D, Magliocco AM, McKay BC, Bebb DG, Lees-Miller SP. Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. Embo Molecular Medicine. 4: 515-27. PMID 22416035 DOI: 10.1002/Emmm.201200229 |
0.532 |
|
| 2012 |
Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K. XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research. 40: 1684-94. PMID 22228831 DOI: 10.1093/Nar/Gkr1315 |
0.574 |
|
| 2012 |
Meek K, Lees-Miller SP, Modesti M. N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research. 40: 2964-73. PMID 22167471 DOI: 10.1093/Nar/Gkr1211 |
0.637 |
|
| 2012 |
Weinfeld M, Lees-Miller SP. DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance Dna Repair in Cancer Therapy. 161-189. DOI: 10.1016/B978-0-12-384999-1.10008-3 |
0.435 |
|
| 2011 |
Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP. Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. Nucleic Acids Research. 39: 9224-37. PMID 21824916 DOI: 10.1093/Nar/Gkr647 |
0.608 |
|
| 2011 |
Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA. XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. The Journal of Biological Chemistry. 286: 32638-50. PMID 21775435 DOI: 10.1074/Jbc.M111.272641 |
0.541 |
|
| 2011 |
Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K. Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Molecular and Cellular Biology. 31: 1719-33. PMID 21300785 DOI: 10.1128/Mcb.01298-10 |
0.664 |
|
| 2011 |
Williamson LM, Lees-Miller SP. Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks. Carcinogenesis. 32: 279-85. PMID 21112959 DOI: 10.1093/Carcin/Bgq255 |
0.515 |
|
| 2010 |
Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. XLF regulates filament architecture of the XRCC4·ligase IV complex. Structure (London, England : 1993). 18: 1431-42. PMID 21070942 DOI: 10.1016/J.Str.2010.09.009 |
0.47 |
|
| 2010 |
Williams GJ, Lees-Miller SP, Tainer JA. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. Dna Repair. 9: 1299-306. PMID 21035407 DOI: 10.1016/J.Dnarep.2010.10.001 |
0.545 |
|
| 2010 |
Dobbs TA, Tainer JA, Lees-Miller SP. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. Dna Repair. 9: 1307-14. PMID 21030321 DOI: 10.1016/J.Dnarep.2010.09.019 |
0.632 |
|
| 2010 |
Doll CM, Prystajecky M, Eliasziw M, Klimowicz AC, Petrillo SK, Craighead PS, Hao D, Diaz R, Lees-Miller SP, Magliocco AM. Low ERCC1 mRNA and protein expression are associated with worse survival in cervical cancer patients treated with radiation alone. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 97: 352-9. PMID 20934765 DOI: 10.1016/J.Radonc.2010.08.019 |
0.3 |
|
| 2010 |
Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. The Journal of Biological Chemistry. 285: 37619-29. PMID 20852255 DOI: 10.1074/Jbc.M109.058719 |
0.523 |
|
| 2010 |
Beattie TL, Lees-Miller SP. Unraveling the roles of WRN and DNA-PKcs at telomeres. Aging. 2: 257-8. PMID 20519782 DOI: v2/n5/full/100150.html |
0.498 |
|
| 2010 |
Li A, Yu Y, Lee SC, Ishibashi T, Lees-Miller SP, Ausió J. Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding. The Journal of Biological Chemistry. 285: 17778-88. PMID 20356835 DOI: 10.1074/Jbc.M110.116426 |
0.544 |
|
| 2010 |
Douglas P, Moorhead G, Xu X, Lees-Miller SP. Choreographing the DNA damage response: PP6 joins the dance Cell Cycle. 9: 1221-1222. PMID 20234171 DOI: 10.4161/Cc.9.7.11321 |
0.615 |
|
| 2010 |
Cobb JA, Lees-Miller SP. DNA double strand breaks: not all foci are created equal. Cell Cycle (Georgetown, Tex.). 9: 442-3. PMID 20130448 DOI: 10.4161/Cc.9.3.10694 |
0.574 |
|
| 2010 |
Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Molecular Cancer Therapeutics. 9: 347-57. PMID 20124459 DOI: 10.1158/1535-7163.MCT-09-0872 |
0.344 |
|
| 2010 |
Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Molecular and Cellular Biology. 30: 1368-81. PMID 20065038 DOI: 10.1128/Mcb.00741-09 |
0.662 |
|
| 2010 |
Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. The Journal of Biological Chemistry. 285: 1414-23. PMID 19893054 DOI: 10.1074/Jbc.M109.065615 |
0.625 |
|
| 2010 |
Zhong J, Liao J, Yao L, Liu J, Stark J, Lees-Miller S, Xie Y, Xu X. Abstract 2988: A PP6-phosphatase complex is required for homology-directed repair of DNA double-strand breaks Cancer Research. 70: 2988-2988. DOI: 10.1158/1538-7445.Am10-2988 |
0.52 |
|
| 2009 |
Ting NS, Pohorelic B, Yu Y, Lees-Miller SP, Beattie TL. The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Research. 37: 6105-15. PMID 19656952 DOI: 10.1093/Nar/Gkp636 |
0.638 |
|
| 2009 |
Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. Dna Repair. 8: 901-11. PMID 19505854 DOI: 10.1016/J.Dnarep.2009.05.003 |
0.631 |
|
| 2009 |
Akopiants K, Zhou RZ, Mohapatra S, Valerie K, Lees-Miller SP, Lee KJ, Chen DJ, Revy P, de Villartay JP, Povirk LF. Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 37: 4055-62. PMID 19420065 DOI: 10.1093/Nar/Gkp283 |
0.55 |
|
| 2009 |
Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, Lees-Miller SP, Meek K, Ullrich RL, Bailey SM. Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Research. 69: 2100-7. PMID 19244120 DOI: 10.1158/0008-5472.Can-08-2854 |
0.62 |
|
| 2009 |
Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. The Biochemical Journal. 417: 639-50. PMID 19133841 DOI: 10.1042/Bj20080413 |
0.645 |
|
| 2009 |
Williamson LM, Williamson CT, Lees-Miller SP. DNA Double strand break repair: Mechanisms and therapeutic potential The Dna Damage Response: Implications On Cancer Formation and Treatment. 157-177. DOI: 10.1007/978-90-481-2561-6_8 |
0.452 |
|
| 2008 |
Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify the ends? Advances in Immunology. 99: 33-58. PMID 19117531 DOI: 10.1016/S0065-2776(08)00602-0 |
0.625 |
|
| 2008 |
Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, Chen DJ, Lees-Miller SP. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. Dna Repair. 7: 1680-92. PMID 18644470 DOI: 10.1016/J.Dnarep.2008.06.015 |
0.669 |
|
| 2008 |
Lees-Miller SP. PIKK-ing a new partner: a new role for PKB in the DNA damage response. Cancer Cell. 13: 379-80. PMID 18455120 DOI: 10.1016/J.Ccr.2008.04.010 |
0.628 |
|
| 2007 |
Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 35: 3869-78. PMID 17526517 DOI: 10.1093/Nar/Gkm339 |
0.547 |
|
| 2007 |
Lees-Miller SP. The double (strand break) life of Par-3. Nature Cell Biology. 9: 363-5. PMID 17401386 DOI: 10.1038/Ncb0407-363 |
0.579 |
|
| 2007 |
Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Molecular and Cellular Biology. 27: 3881-90. PMID 17353268 DOI: 10.1128/Mcb.02366-06 |
0.62 |
|
| 2007 |
Goodarzi AA, Douglas P, Moorhead GB, Lees-Miller SP. Utilizing protein phosphatase inhibitors to define PP2A as a regulator of ataxia-telangiectasia mutated. Methods in Molecular Biology (Clifton, N.J.). 365: 47-59. PMID 17200553 DOI: 10.1385/1-59745-267-X:47 |
0.677 |
|
| 2007 |
Douglas P, Cui X, Block WD, Yu Y, Gupta S, Ding Q, Ye R, Morrice N, Lees-Miller SP, Meek K. The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Molecular and Cellular Biology. 27: 1581-91. PMID 17158925 DOI: 10.1128/Mcb.01962-06 |
0.656 |
|
| 2006 |
Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The Embo Journal. 25: 3880-9. PMID 16874298 DOI: 10.1038/Sj.Emboj.7601255 |
0.794 |
|
| 2006 |
Merkle D, Block WD, Yu Y, Lees-Miller SP, Cramb DT. Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy. Biochemistry. 45: 4164-72. PMID 16566590 DOI: 10.1021/Bi0524060 |
0.62 |
|
| 2006 |
Lees-Miller SP. Dysfunction of lamin A triggers a DNA damage response and cellular senescence. Dna Repair. 5: 286-9. PMID 16344005 DOI: 10.1016/J.Dnarep.2005.10.007 |
0.522 |
|
| 2006 |
Lees-Miller SP. Erratum to “Dysfunction of lamin A triggers a DNA damage response and cellular senescence” [DNA Repair 5 (2006) 286–289] Dna Repair. 5: 649. DOI: 10.1016/J.Dnarep.2006.02.006 |
0.565 |
|
| 2005 |
Cui X, Yu Y, Gupta S, Cho YM, Lees-Miller SP, Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Molecular and Cellular Biology. 25: 10842-52. PMID 16314509 DOI: 10.1128/Mcb.25.24.10842-10852.2005 |
0.624 |
|
| 2005 |
Block WD, Lees-Miller SP. Putative homologues of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and other components of the non-homologous end joining machinery in Dictyostelium discoideum. Dna Repair. 4: 1061-5. PMID 16112620 DOI: 10.1016/J.Dnarep.2005.06.008 |
0.637 |
|
| 2005 |
Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP. DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. Dna Repair. 4: 1006-18. PMID 15941674 DOI: 10.1016/J.Dnarep.2005.05.003 |
0.665 |
|
| 2005 |
Ting NS, Yu Y, Pohorelic B, Lees-Miller SP, Beattie TL. Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Research. 33: 2090-8. PMID 15824061 DOI: 10.1093/Nar/Gki342 |
0.408 |
|
| 2005 |
Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Research. 65: 1670-7. PMID 15753361 DOI: 10.1158/0008-5472.Can-04-3451 |
0.627 |
|
| 2005 |
Convery E, Shin EK, Ding Q, Wang W, Douglas P, Davis LS, Nickoloff JA, Lees-Miller SP, Meek K. Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proceedings of the National Academy of Sciences of the United States of America. 102: 1345-50. PMID 15668400 DOI: 10.1073/Pnas.0406466102 |
0.622 |
|
| 2004 |
Leonenko ZV, Merkle D, Shamrakov LG, Lees-Miller SP, Cramb DT. Examination of surface-bound Ku-DNA complexes in an aqueous environment using MAC mode atomic force microscopy. Biosensors & Bioelectronics. 20: 918-24. PMID 15530788 DOI: 10.1016/J.Bios.2004.06.023 |
0.466 |
|
| 2004 |
Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The Embo Journal. 23: 4451-61. PMID 15510216 DOI: 10.1038/Sj.Emboj.7600455 |
0.678 |
|
| 2004 |
Kurz EU, Douglas P, Lees-Miller SP. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. The Journal of Biological Chemistry. 279: 53272-81. PMID 15489221 DOI: 10.1074/Jbc.M406879200 |
0.595 |
|
| 2004 |
Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Research. 32: 4351-7. PMID 15314205 DOI: 10.1093/Nar/Gkh761 |
0.659 |
|
| 2004 |
Kurz EU, Lees-Miller SP. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. Dna Repair. 3: 889-900. PMID 15279774 DOI: 10.1016/J.Dnarep.2004.03.029 |
0.517 |
|
| 2004 |
Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA. Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. The Journal of Biological Chemistry. 279: 39408-13. PMID 15258142 DOI: 10.1074/Jbc.M406432200 |
0.625 |
|
| 2004 |
Meek K, Gupta S, Ramsden DA, Lees-Miller SP. The DNA-dependent protein kinase: the director at the end. Immunological Reviews. 200: 132-41. PMID 15242401 DOI: 10.1111/J.0105-2896.2004.00162.X |
0.619 |
|
| 2004 |
Merkle D, Lees-Miller SP, Cramb DT. Structure and dynamics of lipoplex formation examined using two-photon fluorescence cross-correlation spectroscopy. Biochemistry. 43: 7263-72. PMID 15182172 DOI: 10.1021/Bi036133P |
0.397 |
|
| 2004 |
Goodarzi AA, Lees-Miller SP. Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells. Dna Repair. 3: 753-67. PMID 15177184 DOI: 10.1016/J.Dnarep.2004.03.041 |
0.728 |
|
| 2004 |
Ye R, Goodarzi AA, Kurz EU, Saito S, Higashimoto Y, Lavin MF, Appella E, Anderson CW, Lees-Miller SP. The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. Dna Repair. 3: 235-44. PMID 15177039 DOI: 10.1016/J.Dnarep.2003.10.014 |
0.765 |
|
| 2004 |
Sawchuk DJ, Mansilla-Soto J, Alarcon C, Singha NC, Langen H, Bianchi ME, Lees-Miller SP, Nussenzweig MC, Cortes P. Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. The Journal of Biological Chemistry. 279: 29821-31. PMID 15123719 DOI: 10.1074/Jbc.M403706200 |
0.643 |
|
| 2004 |
Block WD, Merkle D, Meek K, Lees-Miller SP. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Research. 32: 1967-72. PMID 15060176 DOI: 10.1093/Nar/Gkh508 |
0.664 |
|
| 2004 |
Block WD, Yu Y, Lees-Miller SP. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Research. 32: 997-1005. PMID 14872059 DOI: 10.1093/nar/gkh265 |
0.608 |
|
| 2004 |
Lees-Miller S, Thompson L. Double-Strand Break Repair Reactome - a Curated Knowledgebase of Biological Pathways. 8. DOI: 10.3180/react_2054.1 |
0.343 |
|
| 2003 |
Lees-Miller SP, Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie. 85: 1161-73. PMID 14726021 DOI: 10.1016/J.Biochi.2003.10.011 |
0.614 |
|
| 2003 |
Lee JW, Inamdar KV, Hannah MF, Lees-Miller SP, Povirk LF. DNA end sequestration by DNA-dependent protein kinase and end joining of sterically constrained substrates in whole-cell extracts. Environmental and Molecular Mutagenesis. 42: 279-87. PMID 14673873 DOI: 10.1002/Em.10197 |
0.567 |
|
| 2003 |
Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K, Lees-Miller SP. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. Dna Repair. 2: 1239-52. PMID 14599745 DOI: 10.1016/S1568-7864(03)00143-5 |
0.641 |
|
| 2003 |
Goodarzi AA, Block WD, Lees-Miller SP. The role of ATM and ATR in DNA damage-induced cell cycle control. Progress in Cell Cycle Research. 5: 393-411. PMID 14593734 |
0.701 |
|
| 2003 |
Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Molecular and Cellular Biology. 23: 5836-48. PMID 12897153 DOI: 10.1128/Mcb.23.16.5836-5848.2003 |
0.65 |
|
| 2003 |
Bodero AJ, Ye R, Lees-Miller SP. UV-light induces p38 MAPK-dependent phosphorylation of Bcl10. Biochemical and Biophysical Research Communications. 301: 923-6. PMID 12589800 DOI: 10.1016/S0006-291X(03)00063-9 |
0.455 |
|
| 2002 |
Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry. 41: 12706-14. PMID 12379113 DOI: 10.1021/Bi0263558 |
0.645 |
|
| 2002 |
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical Journal. 368: 507-16. PMID 12234250 DOI: 10.1042/Bj20021284 |
0.727 |
|
| 2002 |
Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. The Biochemical Journal. 368: 243-51. PMID 12186630 DOI: 10.1042/Bj20020973 |
0.78 |
|
| 2002 |
Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees-Miller S, Ellis N, Kondo N, Lavin MF. Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM Journal of Biological Chemistry. 277: 30515-30523. PMID 12034743 DOI: 10.1074/Jbc.M203801200 |
0.503 |
|
| 2002 |
Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF. Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. The Journal of Biological Chemistry. 277: 27162-8. PMID 12023295 DOI: 10.1074/jbc.M204688200 |
0.47 |
|
| 2002 |
Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A. Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. The Embo Journal. 21: 1855-63. PMID 11927569 DOI: 10.1093/Emboj/21.7.1855 |
0.345 |
|
| 2002 |
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. The Journal of Biological Chemistry. 277: 12491-4. PMID 11875057 DOI: 10.1074/Jbc.C200093200 |
0.74 |
|
| 2002 |
Leonenko ZV, Merkle D, Lees-Miller SP, Cramb DT. Lipid phase dependence of DNA-cationic phospholipid bilayer interactions examined using atomic force microscopy Langmuir. 18: 4873-4884. DOI: 10.1021/La0116239 |
0.468 |
|
| 2001 |
Douglas P, Moorhead GB, Ye R, Lees-Miller SP. Protein phosphatases regulate DNA-dependent protein kinase activity. The Journal of Biological Chemistry. 276: 18992-8. PMID 11376007 DOI: 10.1074/Jbc.M011703200 |
0.669 |
|
| 2001 |
Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y, Lee JW, Zhou T, Lees-Miller SP, Povirk LF. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity. The Journal of Biological Chemistry. 276: 24323-30. PMID 11309379 DOI: 10.1074/Jbc.M010544200 |
0.514 |
|
| 2001 |
Curman D, Cinel B, Williams DE, Rundle N, Block WD, Goodarzi AA, Hutchins JR, Clarke PR, Zhou BB, Lees-Miller SP, Andersen RJ, Roberge M. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. The Journal of Biological Chemistry. 276: 17914-9. PMID 11279124 DOI: 10.1074/Jbc.M100728200 |
0.702 |
|
| 2001 |
Ye R, Bodero A, Zhou BB, Khanna KK, Lavin MF, Lees-Miller SP. The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. The Journal of Biological Chemistry. 276: 4828-33. PMID 11096068 DOI: 10.1074/Jbc.M004894200 |
0.593 |
|
| 2000 |
Achari Y, Lees-Miller SP. Detection of DNA-dependent protein kinase in extracts from human and rodent cells. Methods in Molecular Biology (Clifton, N.J.). 99: 85-97. PMID 10909079 DOI: 10.1385/1-59259-054-3:85 |
0.557 |
|
| 2000 |
Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Molecular and Cellular Biology. 20: 3807-16. PMID 10805724 DOI: 10.1128/Mcb.20.11.3807-3816.2000 |
0.331 |
|
| 2000 |
O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC, Rathbun GA. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. The Journal of Biological Chemistry. 275: 22719-27. PMID 10801797 DOI: 10.1074/Jbc.M001002200 |
0.364 |
|
| 2000 |
Chan DW, Son SC, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. The Journal of Biological Chemistry. 275: 7803-10. PMID 10713094 DOI: 10.1074/Jbc.275.11.7803 |
0.705 |
|
| 1999 |
Ting NS, Chan DW, Lintott LG, Allalunis-Turner J, Lees-Miller SP. Protein-DNA complexes containing DNA-dependent protein kinase in crude extracts from human and rodent cells. Radiation Research. 151: 414-22. PMID 10190493 DOI: 10.2307/3579828 |
0.623 |
|
| 1999 |
D'Silva I, Pelletier JD, Lagueux J, D'Amours D, Chaudhry MA, Weinfeld M, Lees-Miller SP, Poirier GG. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochimica Et Biophysica Acta. 1430: 119-26. PMID 10082940 DOI: 10.1016/S0167-4838(98)00278-7 |
0.606 |
|
| 1999 |
Chan DW, Ye R, Veillette CJ, Lees-Miller SP. DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry. 38: 1819-28. PMID 10026262 DOI: 10.1021/Bi982584B |
0.662 |
|
| 1999 |
Parkinson J, Lees-Miller SP, Everett RD. Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. Journal of Virology. 73: 650-7. PMID 9847370 DOI: 10.1128/Jvi.73.1.650-657.1999 |
0.597 |
|
| 1998 |
Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. ATM associates with and phosphorylates p53: mapping the region of interaction. Nature Genetics. 20: 398-400. PMID 9843217 DOI: 10.1038/3882 |
0.515 |
|
| 1998 |
Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Molecular and Cellular Biology. 18: 6719-28. PMID 9774685 DOI: 10.1128/Mcb.18.11.6719 |
0.638 |
|
| 1998 |
Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates JR, Lees-Miller SP, Cole MD, Brandl CJ. Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. The Journal of Biological Chemistry. 273: 26559-65. PMID 9756893 DOI: 10.1074/Jbc.273.41.26559 |
0.373 |
|
| 1998 |
Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394: 700-4. PMID 9716137 DOI: 10.1038/29343 |
0.624 |
|
| 1998 |
Zhao EG, Song Q, Cross S, Misko I, Lees-Miller SP, Lavin MF. Resistance to etoposide-induced apoptosis in a Burkitt's lymphoma cell line. International Journal of Cancer. Journal International Du Cancer. 77: 755-62. PMID 9688310 DOI: 10.1002/(SICI)1097-0215(19980831)77:5<755::AID-IJC15>3.0.CO;2-0 |
0.303 |
|
| 1998 |
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. The Journal of Biological Chemistry. 273: 2136-45. PMID 9442054 DOI: 10.1074/Jbc.273.4.2136 |
0.608 |
|
| 1997 |
Weinfeld M, Chaudhry MA, D'Amours D, Pelletier JD, Poirier GG, Povirk LF, Lees-Miller SP. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiation Research. 148: 22-8. PMID 9216614 DOI: 10.2307/3579534 |
0.63 |
|
| 1997 |
Sullivan KE, Veksler E, Lederman H, Lees-Miller SP. Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. Clinical Immunology and Immunopathology. 82: 43-8. PMID 9000041 DOI: 10.1006/Clin.1996.4275 |
0.505 |
|
| 1997 |
Song Q, Wei T, Lees-Miller S, Alnemri E, Watters D, Lavin MF. Resistance of actin to cleavage during apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 157-62. PMID 8990178 DOI: 10.1073/Pnas.94.1.157 |
0.355 |
|
| 1996 |
Chan DW, Mody CH, Ting NS, Lees-Miller SP. Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 74: 67-73. PMID 9035691 DOI: 10.1139/O96-007 |
0.647 |
|
| 1996 |
Lees-Miller SP. The DNA-dependent protein kinase, DNA-PK: 10 Years and no ends in sight Biochemistry and Cell Biology. 74: 503-512. PMID 8960356 DOI: 10.1139/O96-054 |
0.654 |
|
| 1996 |
Lees-Miller SP, Long MC, Kilvert MA, Lam V, Rice SA, Spencer CA. Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. Journal of Virology. 70: 7471-7. PMID 8892865 DOI: 10.1128/Jvi.70.11.7471-7477.1996 |
0.624 |
|
| 1996 |
Song Q, Burrows SR, Smith G, Lees-Miller SP, Kumar S, Chan DW, Trapani JA, Alnemri E, Litwack G, Lu H, Moss DJ, Jackson S, Lavin MF. Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. The Journal of Experimental Medicine. 184: 619-26. PMID 8760815 DOI: 10.1084/Jem.184.2.619 |
0.595 |
|
| 1996 |
Song Q, Lees-Miller SP, Kumar S, Zhang N, Chan DW, Smith GCM, Jackson SP, Alnemri ES, Litwack G, Khanna KK, Lavin MF. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis Embo Journal. 15: 3238-3246. PMID 8670824 DOI: 10.1002/J.1460-2075.1996.Tb00688.X |
0.621 |
|
| 1996 |
Chan DW, Lees-Miller SP. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit Journal of Biological Chemistry. 271: 8936-8941. PMID 8621537 DOI: 10.1074/Jbc.271.15.8936 |
0.659 |
|
| 1995 |
Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS, Barron GM, Allalunis-Turner J. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (New York, N.Y.). 267: 1183-5. PMID 7855602 DOI: 10.1126/Science.7855602 |
0.641 |
|
| 1995 |
Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell. 82: 849-56. PMID 7671312 DOI: 10.1016/0092-8674(95)90482-4 |
0.755 |
|
| 1995 |
Allalunis-Turner MJ, Lintott LG, Barron GM, Day RS, Lees-Miller SP. Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. Cancer Research. 55: 5200-2. PMID 7585574 |
0.558 |
|
| 1994 |
Anderson CW, Connelly MA, Zhang H, Sipley JD, Lees-Miller SP, Sakaguchi K, Ullrich SJ, Jackson SP, Appella E. The human DNA-activated protein kinase, DNA-PK, is activated by DNA breaks and phosphorylates nuclear DNA-binding protein substrates on serines and threonines following by glutamine Journal of Protein Chemistry. 13: 500-506. |
0.582 |
|
| 1993 |
Fiscella M, Ullrich SJ, Zambrano N, Shields MT, Lin D, Lees-Miller SP, Anderson CW, Mercer WE, Appella E. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene. 8: 1519-28. PMID 8502477 |
0.391 |
|
| 1993 |
Liu SH, Ma JT, Yueh AY, Lees-Miller SP, Anderson CW, Ng SY. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. The Journal of Biological Chemistry. 268: 21147-54. PMID 8407951 |
0.53 |
|
| 1993 |
Abate C, Baker SJ, Lees-Miller SP, Anderson CW, Marshak DR, Curran T. Dimerization and DNA binding alter phosphorylation of Fos and Jun. Proceedings of the National Academy of Sciences of the United States of America. 90: 6766-70. PMID 8341696 DOI: 10.1073/Pnas.90.14.6766 |
0.715 |
|
| 1993 |
Ullrich SJ, Sakaguchi K, Lees-Miller SP, Fiscella M, Mercer WE, Anderson CW, Appella E. Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53. Proceedings of the National Academy of Sciences of the United States of America. 90: 5954-8. PMID 8327466 DOI: 10.1073/Pnas.90.13.5954 |
0.568 |
|
| 1992 |
Anderson CW, Lees-Miller SP. The nuclear serine/threonine protein kinase DNA-PK. Critical Reviews in Eukaryotic Gene Expression. 2: 283-314. PMID 1486241 |
0.59 |
|
| 1992 |
Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Molecular and Cellular Biology. 12: 5041-9. PMID 1406679 DOI: 10.1128/Mcb.12.11.5041 |
0.705 |
|
| 1991 |
Lees-Miller SP, Anderson CW. The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events. Cancer Cells (Cold Spring Harbor, N.Y. : 1989). 3: 341-6. PMID 1751287 |
0.574 |
|
| 1991 |
Chen YR, Lees-Miller SP, Tegtmeyer P, Anderson CW. The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. Journal of Virology. 65: 5131-40. PMID 1654434 DOI: 10.1128/Jvi.65.10.5131-5140.1991 |
0.723 |
|
| 1990 |
Lees-Miller SP, Chen YR, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Molecular and Cellular Biology. 10: 6472-81. PMID 2247067 DOI: 10.1128/Mcb.10.12.6472 |
0.753 |
|
| 1990 |
Jackson SP, MacDonald JJ, Lees-Miller S, Tjian R. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase Cell. 63: 155-165. PMID 2170018 DOI: 10.1016/0092-8674(90)90296-Q |
0.518 |
|
| 1989 |
Lees-Miller SP, Anderson CW. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. The Journal of Biological Chemistry. 264: 17275-80. PMID 2507541 |
0.361 |
|
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