| Year |
Citation |
Score |
| 2024 |
Chrudinová M, Kirk NS, Chuard A, Venugopal H, Zhang F, Lubos M, Gelfanov V, Páníková T, Žáková L, Cutone J, Mojares M, DiMarchi R, Jiráček J, Altindis E. A Viral Insulin-like Peptide Inhibits IGF-1 Receptor Phosphorylation and Regulates IGF1R Gene Expression. Molecular Metabolism. 101863. PMID 38182007 DOI: 10.1016/j.molmet.2023.101863 |
0.341 |
|
| 2023 |
Liskiewicz A, Khalil A, Liskiewicz D, Novikoff A, Grandl G, Maity-Kumar G, Gutgesell RM, Bakhti M, Bastidas-Ponce A, Czarnecki O, Makris K, Lickert H, Feuchtinger A, Tost M, Coupland C, ... ... DiMarchi RD, et al. Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice. Nature Metabolism. PMID 37946085 DOI: 10.1038/s42255-023-00931-7 |
0.628 |
|
| 2023 |
Sachs S, Götz A, Finan B, Feuchtinger A, DiMarchi RD, Döring Y, Weber C, Tschöp MH, Müller TD, Hofmann SM. GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovascular Diabetology. 22: 217. PMID 37592302 DOI: 10.1186/s12933-023-01940-2 |
0.637 |
|
| 2023 |
Campbell JE, Müller TD, Finan B, DiMarchi RD, Tschöp MH, D'Alessio DA. GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. Cell Metabolism. PMID 37591245 DOI: 10.1016/j.cmet.2023.07.010 |
0.683 |
|
| 2022 |
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinová M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nature Communications. 13: 6700. PMID 36335114 DOI: 10.1038/s41467-022-34391-6 |
0.404 |
|
| 2022 |
Quarta C, Stemmer K, Novikoff A, Yang B, Klingelhuber F, Harger A, Bakhti M, Bastidas-Ponce A, Baugé E, Campbell JE, Capozzi M, Clemmensen C, Collden G, Cota P, Douros J, ... ... DiMarchi RD, et al. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism. 4: 1071-1083. PMID 35995995 DOI: 10.1038/s42255-022-00617-6 |
0.641 |
|
| 2022 |
Kim T, Nason S, Antipenko J, Finan B, Shalev A, DiMarchi R, Habegger KM. Hepatic TORC2 Signaling Facilitates Acute Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice. Diabetes. PMID 35877180 DOI: 10.2337/db21-1018 |
0.652 |
|
| 2022 |
Knerr PJ, Mowery SA, Douros JD, Premdjee B, Hjøllund KR, He Y, Kruse Hansen AM, Olsen AK, Perez-Tilve D, DiMarchi RD, Finan B. Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular Metabolism. 101533. PMID 35809773 DOI: 10.1016/j.molmet.2022.101533 |
0.703 |
|
| 2022 |
Dhayalan B, Glidden MD, Zaykov AN, Chen YS, Yang Y, Phillips NB, Ismail-Beigi F, Jarosinski MA, DiMarchi RD, Weiss MA. Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation. Frontiers in Endocrinology. 13: 821069. PMID 35299972 DOI: 10.3389/fendo.2022.821069 |
0.795 |
|
| 2022 |
Tan Q, Akindehin SE, Orsso CE, Waldner RC, DiMarchi RD, Müller TD, Haqq AM. Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes. Frontiers in Endocrinology. 13: 838410. PMID 35299971 DOI: 10.3389/fendo.2022.838410 |
0.35 |
|
| 2022 |
Yang Y, Glidden MD, Dhayalan B, Zaykov AN, Chen YS, Wickramasinghe NP, DiMarchi RD, Weiss MA. Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications. Frontiers in Endocrinology. 13: 821091. PMID 35299958 DOI: 10.3389/fendo.2022.821091 |
0.782 |
|
| 2021 |
He R, Mowery SA, Chabenne J, Finan B, Mayer JP, DiMarchi RD. A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs. Frontiers in Endocrinology. 12: 693958. PMID 34484114 DOI: 10.3389/fendo.2021.693958 |
0.806 |
|
| 2021 |
Zhang F, Altindis E, Kahn CR, DiMarchi RD, Gelfanov V. A Viral Insulin-Like Peptide is a Natural Competitive Antagonist of the Human IGF-1 Receptor. Molecular Metabolism. 101316. PMID 34400347 DOI: 10.1016/j.molmet.2021.101316 |
0.409 |
|
| 2021 |
DiMarchi RD, Mayer JP. Icodec Advances the Prospect of Once-Weekly Insulin Injection. Journal of Medicinal Chemistry. 64: 8939-8941. PMID 34133152 DOI: 10.1021/acs.jmedchem.1c00983 |
0.301 |
|
| 2021 |
DiMarchi RD, Mayer JP. Icodec Advances the Prospect of Once-Weekly Insulin Injection. Journal of Medicinal Chemistry. 64: 8939-8941. PMID 34133152 DOI: 10.1021/acs.jmedchem.1c00983 |
0.301 |
|
| 2021 |
Yang B, Gelfanov VM, Perez-Tilve D, DuBois B, Rohlfs R, Levy J, Douros JD, Finan B, Mayer JP, DiMarchi RD. Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of Medicinal Chemistry. PMID 33821647 DOI: 10.1021/acs.jmedchem.0c02069 |
0.672 |
|
| 2021 |
Zhang Q, Delessa CT, Augustin R, Bakhti M, Colldén G, Drucker DJ, Feuchtinger A, Caceres CG, Grandl G, Harger A, Herzig S, Hofmann S, Holleman CL, Jastroch M, Keipert S, ... ... DiMarchi RD, et al. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell Metabolism. PMID 33571454 DOI: 10.1016/j.cmet.2021.01.015 |
0.63 |
|
| 2021 |
Novikoff A, O'Brien SL, Bernecker M, Grandl G, Kleinert M, Knerr PJ, Stemmer K, Klingenspor M, Zeigerer A, DiMarchi R, Tschöp MH, Finan B, Calebiro D, Müller TD. Spatiotemporal GLP-1 and GIPR receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists. Molecular Metabolism. 101181. PMID 33556643 DOI: 10.1016/j.molmet.2021.101181 |
0.584 |
|
| 2021 |
Nason SR, Antipenko JP, Presedo N, Cunningham SE, Pierre TH, Kim T, Paul JR, Holleman CL, Young ME, Gamble KL, Finan B, DiMarchi R, Hunter CS, Kharitonenkov A, Habegger KM. Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes. Jci Insight. PMID 33411693 DOI: 10.1172/jci.insight.141323 |
0.62 |
|
| 2020 |
Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, ... ... DiMarchi RD, et al. Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission. Nature Metabolism. 2: 380. PMID 33820985 DOI: 10.1038/s42255-020-0201-1 |
0.542 |
|
| 2020 |
Bele S, Girada SB, Ray A, Gupta A, Oruganti S, Prakash Babu P, Rayalla RS, Kalivendi SV, Ibrahim A, Puri V, Adalla V, Katika MR, DiMarchi R, Mitra P. MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice. Elife. 9. PMID 33349332 DOI: 10.7554/eLife.52212 |
0.341 |
|
| 2020 |
Pan J, Parlee SD, Brunel FM, Li P, Lu W, Perez-Tilve D, Liu F, Finan B, Kharitonenkov A, DiMarchi RD. Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21. Acs Pharmacology & Translational Science. 3: 978-986. PMID 33073195 DOI: 10.1021/acsptsci.0c00100 |
0.648 |
|
| 2020 |
Sachs S, Niu L, Geyer P, Jall S, Kleinert M, Feuchtinger A, Stemmer K, Brielmeier M, Finan B, DiMarchi RD, Tschöp MH, Albrechtsen NW, Mann M, Müller TD, Hofmann SM. Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice. Diabetes, Obesity & Metabolism. PMID 33001570 DOI: 10.1111/dom.14215 |
0.641 |
|
| 2020 |
Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, ... ... DiMarchi RD, et al. Targeted pharmacological therapy restores β-cell function for diabetes remission. Nature Metabolism. 2: 192-209. PMID 32694693 DOI: 10.1038/s42255-020-0171-3 |
0.595 |
|
| 2020 |
Stemmer K, Finan B, DiMarchi RD, Tschöp MH, Müller TD. Insights into incretin-based therapies for treatment of diabetic dyslipidemia. Advanced Drug Delivery Reviews. PMID 32485206 DOI: 10.1016/J.Addr.2020.05.008 |
0.658 |
|
| 2020 |
Kabotso DEK, Smiley D, Mayer JP, Gelfanov VM, Perez-Tilve D, DiMarchi RD, Pohl NLB, Liu F. Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. Journal of Medicinal Chemistry. PMID 32406685 DOI: 10.1021/acs.jmedchem.0c00266 |
0.344 |
|
| 2020 |
Brunel FM, Mayer JP, DiMarchi RD. Recent advances in the chemical synthesis of insulin and related peptides. Future Medicinal Chemistry. PMID 32180453 DOI: 10.4155/fmc-2020-0013 |
0.39 |
|
| 2020 |
Hofmann SM, Albrechtsen NJW, Tschöp MH, Feuchtinger A, Brielmeier M, Finan B, Dimarchi R, Kleinert M, Sachs S, Müller TD, Stemmer K, Mann M. 936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice Diabetes. 69. DOI: 10.2337/Db20-936-P |
0.662 |
|
| 2020 |
Presedo N, Kim T, Nason SR, Antipenko J, Finan B, DiMarchi R, Habegger K. Glucagon Regulates Energy Balance via FGF21 Signaling in the Brain The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03065 |
0.573 |
|
| 2019 |
Grandl G, Novikoff A, DiMarchi R, Tschöp MH, Müller TD. Gut Peptide Agonism in the Treatment of Obesity and Diabetes. Comprehensive Physiology. 10: 99-124. PMID 31853954 DOI: 10.1002/Cphy.C180044 |
0.489 |
|
| 2019 |
Knerr PJ, Mowery SA, Finan B, Perez-Tilve D, Tschöp MH, DiMarchi RD. Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. Peptides. 170225. PMID 31786282 DOI: 10.1016/J.Peptides.2019.170225 |
0.681 |
|
| 2019 |
Chabenne J, Mroz PA, Mayer JP, DiMarchi RD. The Structural Refinement of Glucagon for Therapeutic Use. Journal of Medicinal Chemistry. PMID 31774682 DOI: 10.1021/acs.jmedchem.9b01493 |
0.811 |
|
| 2019 |
Li Y, Glotfelty EJ, Namdar I, Tweedie D, Olson L, Hoffer BJ, DiMarchi RD, Pick CG, Greig NH. Neurotrophic and neuroprotective effects of a monomeric GLP-1/GIP/Gcg receptor triagonist in cellular and rodent models of mild traumatic brain injury. Experimental Neurology. 113113. PMID 31730763 DOI: 10.1016/J.Expneurol.2019.113113 |
0.311 |
|
| 2019 |
Nason SR, Kim T, Antipenko JP, Finan B, DiMarchi R, Hunter CS, Habegger KM. Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression. Endocrinology. PMID 31673703 DOI: 10.1210/Endocr/Bqz013 |
0.635 |
|
| 2019 |
Zaykov AN, Gelfanov VM, Perez-Tilve D, Finan B, DiMarchi RD. Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice. Peptides. 120: 170116. PMID 31348991 DOI: 10.1016/J.Peptides.2019.170116 |
0.842 |
|
| 2019 |
Brunel FM, Mayer JP, Gelfanov VM, Zaykov AN, Finan B, Perez-Tilve D, DiMarchi RD. A disulfide-scan of insulin by [3+1] methodology exhibits site-specific influence on bioactivity. Acs Chemical Biology. PMID 31343157 DOI: 10.1021/Acschembio.9B00420 |
0.832 |
|
| 2019 |
He R, Finan B, Mayer JP, DiMarchi RD. Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety. Molecules (Basel, Switzerland). 24. PMID 31091786 DOI: 10.3390/Molecules24101855 |
0.612 |
|
| 2019 |
Décarie-Spain L, Fisette A, Zhu Z, Yang B, DiMarchi RD, Tschöp MH, Finan B, Fulton S, Clemmensen C. GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice. Neuropharmacology. PMID 30946847 DOI: 10.1016/J.Neuropharm.2019.03.035 |
0.615 |
|
| 2019 |
Ratner C, He Z, Grunddal KV, Skov LJ, Hartmann B, Zhang F, Feuchtinger A, Bjerregaard A, Christoffersen C, Tschöp MH, Finan B, DiMarchi RD, Leinninger GM, Williams KW, Clemmensen C, et al. Long Acting Neurotensin Synergizes with Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway. Diabetes. PMID 30936142 DOI: 10.2337/Db18-1009 |
0.629 |
|
| 2019 |
Bethea M, Liu Y, Wade AK, Mullen R, Gupta R, Gelfanov V, DiMarchi R, Bhatnagar S, Behringer R, Habegger KM, Hunter CS. The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis. American Journal of Physiology. Endocrinology and Metabolism. PMID 30620636 DOI: 10.1152/Ajpendo.00235.2018 |
0.361 |
|
| 2019 |
KIM T, ANTIPENKO JP, NASON S, PRESEDO N, VAN DER POL WJ, FINAN B, DIMARCHI R, MORROW CD, HABEGGER KM. 1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice Diabetes. 68: 1965-P. DOI: 10.2337/Db19-1965-P |
0.664 |
|
| 2019 |
Nason S, Kim T, Antipenko JP, Finan B, Dimarchi R, Habegger KM. 1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression Diabetes. 68. DOI: 10.2337/Db19-1870-P |
0.642 |
|
| 2019 |
Kim T, Nason S, Antipenko J, Presedo N, Finan B, DiMarchi R, Habegger K. OR28-5 Bile Acid Sequestration Accelerates Glucagon Receptor-Mediated Body Weight Loss in Obese Mice Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Or28-5 |
0.648 |
|
| 2018 |
Mroz PA, Finan B, Gelfanov V, Yang B, Tschöp MH, DiMarchi RD, Perez-Tilve D. Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism. Molecular Metabolism. PMID 30578168 DOI: 10.1016/J.Molmet.2018.12.001 |
0.607 |
|
| 2018 |
Clemmensen C, Finan B, Müller TD, DiMarchi RD, Tschöp MH, Hofmann SM. Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases. Nature Reviews. Endocrinology. PMID 30446744 DOI: 10.1038/S41574-018-0118-X |
0.659 |
|
| 2018 |
Zhang F, Mayer J, Gelfanov V, Liu F, DiMarchi R. Structurally Constrained Insulin Analogs by Directed Stepwise Cross-linking. Protein and Peptide Letters. PMID 30381053 DOI: 10.2174/0929866525666181101103500 |
0.326 |
|
| 2018 |
Brandt SJ, Müller TD, DiMarchi RD, Tschöp MH, Stemmer K. Peptide-based multi-agonists: a new paradigm in metabolic pharmacology. Journal of Internal Medicine. PMID 30230640 DOI: 10.1111/joim.12837 |
0.401 |
|
| 2018 |
Rivero-Gutierrez B, Haller A, Holland J, Yates E, Khrisna R, Habegger K, Dimarchi R, D'Alessio D, Perez-Tilve D. Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular Metabolism. PMID 30170980 DOI: 10.1016/J.Molmet.2018.07.012 |
0.381 |
|
| 2018 |
Kim T, Holleman CL, Nason S, Arble DM, Ottaway N, Chabenne J, Loyd C, Kim JA, Sandoval D, Drucker DJ, DiMarchi R, Perez-Tilve D, Habegger KM. Hepatic Glucagon-Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes. PMID 30150304 DOI: 10.2337/Db18-0068 |
0.816 |
|
| 2018 |
Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H. An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation. Cellular Signalling. 51: 13-22. PMID 30055232 DOI: 10.1016/J.Cellsig.2018.07.006 |
0.655 |
|
| 2018 |
Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, ... ... DiMarchi R, et al. Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs. Molecular Metabolism. PMID 30017782 DOI: 10.1016/J.Molmet.2018.06.015 |
0.625 |
|
| 2018 |
Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschoep M, et al. Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes. PMID 29925501 DOI: 10.2337/Db17-1502 |
0.655 |
|
| 2018 |
Capozzi ME, DiMarchi RD, Tschöp MH, Finan B, Campbell JE. Targeting the Incretin/Glucagon System with Triagonists to Treat Diabetes. Endocrine Reviews. PMID 29905825 DOI: 10.1210/Er.2018-00117 |
0.675 |
|
| 2018 |
Zaykov AN, Gelfanov VM, Liu F, DiMarchi RD. High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy. Organic Letters. PMID 29874090 DOI: 10.1021/acs.orglett.8b01501 |
0.775 |
|
| 2018 |
Agrawal A, Parlee S, Perez-Tilve D, Li P, Pan J, Mroz PA, Kruse Hansen AM, Andersen B, Finan B, Kharitonenkov A, DiMarchi RD. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Molecular Metabolism. PMID 29789271 DOI: 10.1016/J.Molmet.2018.05.003 |
0.59 |
|
| 2018 |
Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29467286 DOI: 10.1073/Pnas.1721117115 |
0.471 |
|
| 2018 |
Zaykov A, Gelfanov V, Liu F, DiMarchi RD, DiMarchi RD. Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5. Chemmedchem. PMID 29466617 DOI: 10.1002/cmdc.201800057 |
0.813 |
|
| 2018 |
Brandt SJ, Mayer JP, Ford J, Gelfanov VM, DiMarchi RD. Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity. Peptides. 100: 18-23. PMID 29412818 DOI: 10.1016/j.peptides.2017.11.022 |
0.367 |
|
| 2018 |
DiMarchi RD, Mayer JP, Gelfanov VM, Tschöp M. Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases. Journal of Peptide Science : An Official Publication of the European Peptide Society. 24. PMID 29322647 DOI: 10.1002/psc.3056 |
0.351 |
|
| 2018 |
KIM T, NASON S, ANTIPENKO JP, VESTRI CS, SMITH-JOHNSTON K, PEPIN ME, WENDE AR, FINAN B, DIMARCHI R, PEREZ-TILVE D, MOELLERING DR, HABEGGER KM. Glucagon-Receptor Signaling Regulates Mitochondrial Bioenergetics via Hepatic Farnesol X Receptor Diabetes. 67: 1978-P. DOI: 10.2337/Db18-1978-P |
0.636 |
|
| 2017 |
Knerr PJ, Finan B, Gelfanov V, Perez-Tilve D, Tschöp MH, DiMarchi RD. Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorganic & Medicinal Chemistry. PMID 29153547 DOI: 10.1016/J.Bmc.2017.10.047 |
0.637 |
|
| 2017 |
Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, ... ... DiMarchi RD, et al. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metabolism. PMID 28943448 DOI: 10.1016/J.Cmet.2017.08.023 |
0.68 |
|
| 2017 |
Khajavi N, Biebermann H, Tschöp M, DiMarchi R. Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors. Endocrine Development. 32: 165-182. PMID 28873389 DOI: 10.1159/000475737 |
0.5 |
|
| 2017 |
Liu F, Li P, Gelfanov V, Mayer J, DiMarchi R. Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity. Accounts of Chemical Research. PMID 28771323 DOI: 10.1021/Acs.Accounts.7B00227 |
0.542 |
|
| 2017 |
Portron A, Jadidi S, Sarkar N, DiMarchi R, Schmitt C. Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 after single subcutaneous administration in healthy subjects. Diabetes, Obesity & Metabolism. PMID 28741871 DOI: 10.1111/Dom.13025 |
0.422 |
|
| 2017 |
Sánchez-Garrido MA, Brandt SJ, Clemmensen C, Müller TD, DiMarchi RD, Tschöp MH. GLP-1/glucagon receptor co-agonism for treatment of obesity. Diabetologia. PMID 28733905 DOI: 10.1007/s00125-017-4354-8 |
0.338 |
|
| 2017 |
Schmitt C, Portron A, Jadidi S, Sarkar N, DiMarchi R. Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus. Diabetes, Obesity & Metabolism. PMID 28730694 DOI: 10.1111/Dom.13024 |
0.42 |
|
| 2017 |
Tschöp M, DiMarchi R. Single-Molecule Combinatorial Therapeutics for Treating Obesity and Diabetes. Diabetes. PMID 28603138 DOI: 10.2337/Dbi16-0068 |
0.4 |
|
| 2017 |
Thalluri K, Kou B, Yang X, Zaykov AN, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD. Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 28466571 DOI: 10.1002/psc.3010 |
0.809 |
|
| 2017 |
Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice. Molecular Metabolism. 6: 440-446. PMID 28462078 DOI: 10.1016/J.Molmet.2017.02.002 |
0.668 |
|
| 2017 |
Wu F, Mayer JP, Gelfanov VG, Liu F, DiMarchi RD. Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation. The Journal of Organic Chemistry. PMID 28319665 DOI: 10.1021/acs.joc.6b03078 |
0.348 |
|
| 2017 |
Thalluri K, Kou B, Gelfanov V, Mayer JP, Liu F, DiMarchi RD. Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision. Organic Letters. PMID 28124920 DOI: 10.1021/acs.orglett.6b03876 |
0.36 |
|
| 2017 |
Kharitonenkov A, DiMarchi R. Fibroblast growth factor 21 night watch: advances and uncertainties in the field. Journal of Internal Medicine. 281: 233-246. PMID 27878865 DOI: 10.1111/Joim.12580 |
0.324 |
|
| 2016 |
Mroz PA, Perez-Tilve D, Liu F, Mayer JP, DiMarchi RD. Native design of soluble, aggregation-resistant bioactive peptides: Chemical evolution of human glucagon. Acs Chemical Biology. PMID 27797473 DOI: 10.1021/acschembio.6b00923 |
0.313 |
|
| 2016 |
Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, ... ... DiMarchi R, et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. PMID 27720451 DOI: 10.1016/J.Cell.2016.09.014 |
0.659 |
|
| 2016 |
Sánchez-Garrido MA, Habegger KM, Clemmensen C, Holleman C, Müller TD, Perez-Tilve D, Li P, Agrawal AS, Finan B, Drucker DJ, Tschöp MH, DiMarchi RD, Kharitonenkov A. Fibroblast activation protein (FAP) as a novel metabolic target. Molecular Metabolism. 5: 1015-24. PMID 27689014 DOI: 10.1016/J.Molmet.2016.07.003 |
0.57 |
|
| 2016 |
Mroz PA, Perez-Tilve D, Liu F, Gelfanov V, DiMarchi RD, Mayer JP. Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization. Journal of Medicinal Chemistry. PMID 27509198 DOI: 10.1021/acs.jmedchem.6b00840 |
0.371 |
|
| 2016 |
Vogel H, Wolf S, Rabasa C, Rodriguez-Pacheco F, Babaei CS, Stöber F, Goldschmidt J, DiMarchi RD, Finan B, Tschöp MH, Dickson SL, Schürmann A, Skibicka KP. GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight. Neuropharmacology. PMID 27496691 DOI: 10.1016/J.Neuropharm.2016.07.039 |
0.592 |
|
| 2016 |
Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell Metabolism. 24: 51-62. PMID 27411008 DOI: 10.1016/J.Cmet.2016.06.021 |
0.615 |
|
| 2016 |
Wu F, Mayer JP, Zaykov AN, Zhang F, Liu F, DiMarchi RD. Chemical Synthesis of Human Insulin-Like Peptide-6. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27259101 DOI: 10.1002/Chem.201601410 |
0.806 |
|
| 2016 |
Zaykov AN, Mayer JP, DiMarchi RD. Pursuit of a perfect insulin. Nature Reviews. Drug Discovery. PMID 26988411 DOI: 10.1038/nrd.2015.36 |
0.799 |
|
| 2016 |
Liu F, Zaykov AN, Levy JJ, DiMarchi RD, Mayer JP. Chemical synthesis of peptides within the insulin superfamily. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26910514 DOI: 10.1002/psc.2863 |
0.821 |
|
| 2015 |
Heppner KM, Marks S, Holland J, Ottaway N, Smiley D, Dimarchi R, Perez-Tilve D. Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia. 58: 2124-32. PMID 26049402 DOI: 10.1007/S00125-015-3651-3 |
0.425 |
|
| 2015 |
Tiano JP, Tate CR, Yang BS, DiMarchi R, Mauvais-Jarvis F. Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis. Scientific Reports. 5: 10211. PMID 25970118 DOI: 10.1038/Srep10211 |
0.44 |
|
| 2015 |
Clemmensen C, Müller TD, Finan B, Tschöp MH, DiMarchi R. Current and Emerging Treatment Options in Diabetes Care. Handbook of Experimental Pharmacology. PMID 25903416 DOI: 10.1007/164_2015_7 |
0.653 |
|
| 2015 |
Wu F, Chabenne JR, Gelfanov VM, Mayer JP, DiMarchi RD. Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 223-30. PMID 25665061 DOI: 10.1002/Psc.2744 |
0.803 |
|
| 2015 |
Schwenk RW, Baumeier C, Finan B, Kluth O, Brauer C, Joost HG, DiMarchi RD, Tschöp MH, Schürmann A. GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice. Diabetologia. 58: 604-14. PMID 25527001 DOI: 10.1007/S00125-014-3478-3 |
0.612 |
|
| 2015 |
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, ... ... DiMarchi RD, et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature Medicine. 21: 27-36. PMID 25485909 DOI: 10.1038/Nm.3761 |
0.838 |
|
| 2015 |
Tiano JP, Tate CR, Yang BS, Dimarchi R, Mauvais-Jarvis F. Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis Scientific Reports. 5. DOI: 10.1038/srep10211 |
0.384 |
|
| 2015 |
Müller TD, Clemmensen C, Finan B, Dimarchi RD, Tschöp MH. Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases Leptin: Regulation and Clinical Applications. 267-279. DOI: 10.1007/978-3-319-09915-6_21 |
0.552 |
|
| 2014 |
Kharitonenkov A, Dimarchi R. Break on through to the other 1 Cell Metabolism. 20: 554-555. PMID 25295781 DOI: 10.1016/J.Cmet.2014.09.009 |
0.365 |
|
| 2014 |
Chabenne J, Chabenne MD, Zhao Y, Levy J, Smiley D, Gelfanov V, Dimarchi R. A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia. Molecular Metabolism. 3: 293-300. PMID 24749059 DOI: 10.1016/J.Molmet.2014.01.006 |
0.791 |
|
| 2014 |
Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann SM, Schriever SC, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD. GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes. 63: 1422-7. PMID 24379349 DOI: 10.2337/Db13-1609 |
0.817 |
|
| 2014 |
Zaykov AN, Mayer JP, Gelfanov VM, DiMarchi RD. Chemical synthesis of insulin analogs through a novel precursor. Acs Chemical Biology. 9: 683-91. PMID 24328449 DOI: 10.1021/cb400792s |
0.798 |
|
| 2014 |
Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, et al. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes. 63: 505-13. PMID 24186863 DOI: 10.2337/Db13-0511 |
0.321 |
|
| 2014 |
Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 63: 122-31. PMID 24062249 DOI: 10.2337/Db13-0414 |
0.421 |
|
| 2014 |
Schwenk RW, Baumeier C, Finan B, Kluth O, Brauer C, Joost HG, DiMarchi RD, Tschöp MH, Schürmann A. GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice Diabetologia. 58: 604-614. DOI: 10.1007/s00125-014-3478-3 |
0.582 |
|
| 2013 |
Ward BP, Ottaway NL, Perez-Tilve D, Ma D, Gelfanov VM, Tschöp MH, Dimarchi RD. Peptide lipidation stabilizes structure to enhance biological function. Molecular Metabolism. 2: 468-79. PMID 24327962 DOI: 10.1016/J.Molmet.2013.08.008 |
0.666 |
|
| 2013 |
Patterson JT, Li P, Day JW, Gelfanov VM, Dimarchi RD. A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction. Molecular Metabolism. 2: 86-91. PMID 24199154 DOI: 10.1016/J.Molmet.2013.01.003 |
0.7 |
|
| 2013 |
Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, ... ... DiMarchi RD, et al. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans Science Translational Medicine. 5. PMID 24174327 DOI: 10.1126/Scitranslmed.3007218 |
0.72 |
|
| 2013 |
Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, ... ... DiMarchi R, et al. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature Communications. 4: 1968. PMID 23744028 DOI: 10.1038/Ncomms2968 |
0.675 |
|
| 2013 |
Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD. Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker. Acs Chemical Biology. 8: 1822-9. PMID 23730814 DOI: 10.1021/cb4002624 |
0.769 |
|
| 2013 |
Kuna RS, Girada SB, Asalla S, Vallentyne J, Maddika S, Patterson JT, Smiley DL, DiMarchi RD, Mitra P. Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells. American Journal of Physiology. Endocrinology and Metabolism. 305: E161-70. PMID 23592482 DOI: 10.1152/Ajpendo.00551.2012 |
0.714 |
|
| 2013 |
Campanello GC, Ma Z, Grossoehme NE, Guerra AJ, Ward BP, Dimarchi RD, Ye Y, Dann CE, Giedroc DP. Allosteric inhibition of a zinc-sensing transcriptional repressor: Insights into the arsenic repressor (ArsR) family Journal of Molecular Biology. 425: 1143-1157. PMID 23353829 DOI: 10.1016/J.Jmb.2013.01.018 |
0.545 |
|
| 2013 |
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, ... ... DiMarchi RD, et al. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes. 62: 1453-63. PMID 23305646 DOI: 10.2337/Db12-1116 |
0.338 |
|
| 2013 |
Müller T, Müller A, Habegger K, Yi C, Meyer C, Gaylinn B, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski C, Pratzka J, Stemmer K, ... ... DiMarchi R, et al. The orphan receptor GPR83 regulates systemic energy metabolism via ghrelin-dependent and -independent mechanisms Experimental and Clinical Endocrinology & Diabetes. 121. DOI: 10.1055/S-0033-1336629 |
0.615 |
|
| 2013 |
Ward BP, Ottaway NL, Perez-Tilve D, Ma D, Gelfanov VM, Tschöp MH, DiMarchi RD. Peptide lipidation stabilizes structure to enhance biological function Molecular Metabolism. 2: 468-479. DOI: 10.1016/j.molmet.2013.08.008 |
0.622 |
|
| 2012 |
Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. Biopolymers. 98: 443-50. PMID 23203689 DOI: 10.1002/Bip.22072 |
0.474 |
|
| 2012 |
Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, ... ... DiMarchi RD, et al. Targeted estrogen delivery reverses the metabolic syndrome. Nature Medicine. 18: 1847-56. PMID 23142820 DOI: 10.1038/Nm.3009 |
0.683 |
|
| 2012 |
Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling Diabetes. 61: 2753-2762. PMID 22933116 DOI: 10.2337/Db11-1556 |
0.813 |
|
| 2012 |
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology. 153: 4687-95. PMID 22865372 DOI: 10.1210/En.2012-1194 |
0.384 |
|
| 2012 |
Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT, DeGuzman MJ, Siladi ME, Kraynov VS, ... ... DiMarchi R, et al. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. Journal of Peptide Science : An Official Publication of the European Peptide Society. 18: 383-93. PMID 22565812 DOI: 10.1002/Psc.2408 |
0.392 |
|
| 2012 |
Mu J, Pinkstaff J, Li Z, Skidmore L, Li N, Myler H, Dallas-Yang Q, Putnam AM, Yao J, Bussell S, Wu M, Norman TC, Rodriguez CG, Kimmel B, Metzger JM, ... ... DiMarchi RD, et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes. 61: 505-12. PMID 22210323 DOI: 10.2337/Db11-0838 |
0.322 |
|
| 2011 |
Patterson JT, Day JW, Gelfanov VM, DiMarchi RD. Functional association of the N-terminal residues with the central region in glucagon-related peptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 659-66. PMID 21661079 DOI: 10.1002/Psc.1385 |
0.729 |
|
| 2011 |
Wiedmer P, Strasser F, Horvath TL, Blum D, Dimarchi R, Lutz T, Schürmann A, Joost HG, Tschöp MH, Tong J. Ghrelin-induced hypothermia: a physiological basis but no clinical risk. Physiology & Behavior. 105: 43-51. PMID 21513721 DOI: 10.1016/J.Physbeh.2011.03.027 |
0.313 |
|
| 2011 |
Day JW, Li P, Patterson JT, Chabenne J, Chabenne MD, Gelfanov VM, Dimarchi RD. Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 218-25. PMID 21308878 DOI: 10.1002/Psc.1317 |
0.815 |
|
| 2011 |
Patterson JT, Ottaway N, Gelfanov VM, Smiley DL, Perez-Tilve D, Pfluger PT, Tschöp MH, Dimarchi RD. A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. Acs Chemical Biology. 6: 135-45. PMID 20939591 DOI: 10.1021/Cb1002015 |
0.721 |
|
| 2010 |
Chabenne JR, DiMarchi MA, Gelfanov VM, DiMarchi RD. Optimization of the native glucagon sequence for medicinal purposes Journal of Diabetes Science and Technology. 4: 1322-1331. PMID 21129326 DOI: 10.1177/193229681000400605 |
0.808 |
|
| 2010 |
Habegger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH. The metabolic actions of glucagon revisited. Nature Reviews. Endocrinology. 6: 689-97. PMID 20957001 DOI: 10.1038/Nrendo.2010.187 |
0.486 |
|
| 2010 |
Bohrer BC, Li YF, Reilly JP, Clemmer DE, DiMarchi RD, Radivojac P, Tang H, Arnold RJ. Combinatorial libraries of synthetic peptides as a model for shotgun proteomics. Analytical Chemistry. 82: 6559-68. PMID 20669997 DOI: 10.1021/Ac100910A |
0.301 |
|
| 2010 |
De A, DiMarchi RD. Synthesis and characterization of ester-based prodrugs of glucagon-like peptide 1. Biopolymers. 94: 448-56. PMID 20593470 DOI: 10.1002/Bip.21418 |
0.622 |
|
| 2010 |
Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, ... ... DiMarchi RD, et al. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature Neuroscience. 13: 877-82. PMID 20526334 DOI: 10.1038/Nn.2569 |
0.601 |
|
| 2010 |
Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M. Glucagon regulation of energy metabolism. Physiology & Behavior. 100: 545-8. PMID 20381509 DOI: 10.1016/J.Physbeh.2010.03.019 |
0.707 |
|
| 2009 |
Ma Z, Cowart DM, Ward BP, Arnold RJ, DiMarchi RD, Zhang L, George GN, Scott RA, Giedroc DP. Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor Journal of the American Chemical Society. 131: 18044-18045. PMID 19928961 DOI: 10.1021/Ja908372B |
0.527 |
|
| 2009 |
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, ... ... DiMarchi R, et al. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nature Chemical Biology. 5: 749-57. PMID 19597507 DOI: 10.1038/Nchembio.209 |
0.754 |
|
| 2009 |
Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5916-25. PMID 19420258 DOI: 10.1523/Jneurosci.5977-08.2009 |
0.71 |
|
| 2008 |
De A, DiMarchi RD. Investigation of the feasibility of an amide-based prodrug under physiological conditions (International Journal of Peptide Research and Therapeutics DOI: 10.1007/s10989-008-9141-4) International Journal of Peptide Research and Therapeutics. 14: 393. DOI: 10.1007/S10989-008-9152-1 |
0.606 |
|
| 2007 |
Yan LZ, Hsiung HM, Heiman ML, Gadski RA, Emmerson PJ, Hertel J, Flora D, Edwards P, Smiley D, Zhang L, Husain S, Kahl SD, DiMarchi RD, Mayer JP. Structure-activity relationships of β-MSH derived melanocortin-4 receptor peptide agonists Current Topics in Medicinal Chemistry. 7: 1052-1067. PMID 17584126 DOI: 10.2174/156802607780906591 |
0.356 |
|
| 2007 |
Mayer JP, Zhang F, DiMarchi RD. Insulin structure and function Biopolymers - Peptide Science Section. 88: 687-713. PMID 17410596 DOI: 10.1002/bip.20734 |
0.352 |
|
| 2007 |
Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, Strifler BA, Li S, Shang J, Beals JM, Mayer JP, DiMarchi RD. pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity. Peptides. 28: 935-48. PMID 17328992 DOI: 10.1016/j.peptides.2007.01.012 |
0.364 |
|
| 2007 |
Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, et al. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology. 148: 21-6. PMID 17008393 DOI: 10.1210/En.2006-0915 |
0.394 |
|
| 2005 |
Zhang F, Chen Y, Heiman M, DiMarchi R. Leptin: Structure, Function and Biology Vitamins and Hormones. 71: 345-372. PMID 16112274 DOI: 10.1016/S0083-6729(05)71012-8 |
0.411 |
|
| 1998 |
Radziuk J, Pye S, Bradley B, Braaten J, Vignati L, Roach P, Bowsher R, DiMarchi R, Chance R. Basal activity profiles of NPH and [N(ε)-palmitoyl Lys (B29)] human insulins in subjects with IDDM Diabetologia. 41: 116-120. PMID 9498640 DOI: 10.1007/S001250050876 |
0.419 |
|
| 1998 |
Radziuk J, Pye S, Bradley B, Braaten J, Vignati L, Roach P, Bowsher R, DiMarchi R, Chance R. Erratum: Basal activity profiles of NPH and [N(ε)-palmitoyl Lys (B29)] human insulins in subjects with IDDM (Rapid communication) (Diabetologia (1998) 41 (116-120)) Diabetologia. 41: 489-490. DOI: 10.1007/S001250050936 |
0.338 |
|
| 1997 |
Slieker LJ, Brooke GS, Dimarchi RD, Flora DB, Green LK, Hoffmann JA, Long HB, Fan L, Shields JE, Sundell KL, Surface PL, Chance RE. Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor Diabetologia. 40: S54-S61. PMID 9248702 DOI: 10.1007/S001250051402 |
0.332 |
|
| 1997 |
Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Di Cera E, Williamson JR. Prevention of vascular and neural dysfunction in diabetic rats by C- peptide Science. 277: 563-566. PMID 9228006 DOI: 10.1126/Science.277.5325.563 |
0.354 |
|
| 1997 |
Anderson JH, Brunelle RL, Keohane P, Koivisto VA, Trautmann ME, Vignati L, DiMarchi R. Mealtime treatment with insulin analog improves postprandial hyperglycemia and hypoglycemia in patients with non-insulin-dependent diabetes mellitus Archives of Internal Medicine. 157: 1249-1255. PMID 9183237 DOI: 10.1001/Archinte.1997.00440320157015 |
0.419 |
|
| 1997 |
Anderson JH, Brunelle RL, Koivisto VA, Trautmann ME, Vignati L, DiMarchi R, Cameron DP, Yeu DK, Zimmet P, Lauvaux JP, Van Gaal LF, Chiasson JL, Fettes IM, Tan MH, Toth EL, et al. Improved mealtime treatment of diabetes mellitus using an insulin analogue Clinical Therapeutics. 19: 62-72. PMID 9083709 DOI: 10.1016/S0149-2918(97)80073-2 |
0.417 |
|
| 1997 |
Radziuk JM, Davies JC, Pye WS, Shields JE, DiMarchi RD, Chance RE. Bioavailability and bioeffectiveness of subcutaneous human insulin and two of its analogs-Lys(B28)Pro(B29)-human insulin and Asp(B10)Lys(B28)Pro(B29)-human insulin-assessed in a conscious pig model Diabetes. 46: 548-556. PMID 9075793 DOI: 10.2337/Diab.46.4.548 |
0.309 |
|
| 1997 |
Anderson JH, Brunelle RL, Koivisto VA, Pfützner A, Trautmann ME, Vignati L, DiMarchi R. Reduction of postprandial hyperglycemia and frequency of hypoglycemia in IDDM patients on insulin-analog treatment Diabetes. 46: 265-270. PMID 9000704 DOI: 10.2337/Diab.46.2.265 |
0.415 |
|
| 1994 |
DiMarchi RD, Chance RE, Long HB, Shields JE, Slieker LJ. Preparation of an insulin with improved pharmacokinetics relative to human insulin through consideration of structural homology with insulin-like growth factor I Hormone Research. 41: 93-96. PMID 8088710 DOI: 10.1159/000183967 |
0.332 |
|
| 1994 |
Burguera B, Elton CW, Tapscott EB, Pories WJ, Dimarchi R, Sakano -i. K, Dohm GL. Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor Biochemical Journal. 300: 781-785. PMID 8010960 DOI: 10.1042/Bj3000781 |
0.385 |
|
| 1993 |
Slieker LJ, Brooke GS, Chance RE, Fan L, Hoffmann JA, Howey DC, Long HB, Mayer J, Shields JE, Sundell KL, DiMarchi RD. Insulin and IGF-I analogs: Novel approaches to improved insulin pharmacokinetics Advances in Experimental Medicine and Biology. 343: 25-32. PMID 8184740 DOI: 10.1007/978-1-4615-2988-0_3 |
0.339 |
|
| 1992 |
Heath WF, Belagaje RM, Brooke GS, Chance RE, Hoffmann JA, Long HB, Reams SG, Roundtree C, Shaw WN, Slieker LJ, Sundell KL, DiMarchi RD. (A-C-B) human proinsulin, a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin Journal of Biological Chemistry. 267: 419-425. PMID 1730606 |
0.378 |
|
| 1992 |
Flynn JN, Harkiss GD, Moore D, DiMarchi R. Modulation of T-cell reactivity to synthetic peptide analogues of foot-and-mouth disease virus in sheep by amino acid substitutions Veterinary Immunology and Immunopathology. 31: 255-266. PMID 1375405 DOI: 10.1016/0165-2427(92)90013-G |
0.392 |
|
| 1992 |
Doel TR, Doel CMFA, Staple RF, DiMarchi R. Cross-reactive and serotype-specific antibodies against foot-and-mouth disease virus generated by different regions of the same synthetic peptide Journal of Virology. 66: 2187-2194. PMID 1372368 DOI: 10.1128/Jvi.66.4.2187-2194.1992 |
0.35 |
|
| 1991 |
Rossetti L, Frontoni S, Dimarchi R, DeFronzo RA, Giaccari A. Metabolic effects of IGF-I in diabetic rats Diabetes. 40: 444-448. PMID 2010044 DOI: 10.2337/Diab.40.4.444 |
0.397 |
|
| 1991 |
Bodkin NL, Sportsman R, DiMarchi RD, Hansen BC. Insulin-like growth factor-I in non-insulin-dependent diabetic monkeys: Basal plasma concentrations and metabolic effects of exogenously administered biosynthetic hormone Metabolism. 40: 1131-1137. PMID 1943741 DOI: 10.1016/0026-0495(91)90206-C |
0.326 |
|
| 1991 |
Burguera B, Frank BH, DiMarchi R, Long S, Caro JF. The interaction of proinsulin with the insulin-like growth factor-I receptor in human liver, muscle, and adipose tissue Journal of Clinical Endocrinology and Metabolism. 72: 1238-1241. PMID 1851182 DOI: 10.1210/Jcem-72-6-1238 |
0.386 |
|
| 1990 |
Dohm GL, Elton CW, Raju MS, Mooney ND, DiMarchi R, Pories WJ, Flickinger EG, Atkinson SM, Caro JF. IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM Diabetes. 39: 1028-1032. PMID 2166697 DOI: 10.2337/Diab.39.9.1028 |
0.377 |
|
| 1990 |
Doel TR, Gale C, Do Amaral CM, Mulcahy G, Dimarchi R. Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus. Journal of Virology. 64: 2260-4. PMID 2157884 DOI: 10.1128/Jvi.64.5.2260-2264.1990 |
0.38 |
|
| 1990 |
Sinha MK, Buchanan C, Raineri-Maldonado C, Khazanie P, Atkinson S, DiMarchi R, Caro JF. IGF-II receptors and IGF-II-stimulated glucose transport in human fat cells. The American Journal of Physiology. 258: E534-42. PMID 2156441 DOI: 10.1152/Ajpendo.1990.258.3.E534 |
0.387 |
|
| 1989 |
Sinha MK, Buchanan C, Leggett N, Martin L, Khazanie PG, Dimarchi R, Pories WJ, Caro JF. Mechanism of IGF-I-stimulated glucose transport in human adipocytes. Demonstration of specific IGF-I receptors not involved in stimulation of glucose transport. Diabetes. 38: 1217-25. PMID 2551760 DOI: 10.2337/Diab.38.10.1217 |
0.406 |
|
| 1989 |
Thakker JK, DiMarchi R, MacDonald K, Caro JF. Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes. The Journal of Biological Chemistry. 264: 7169-75. PMID 2540178 |
0.307 |
|
| 1988 |
Doel TR, Gale C, Brooke G, DiMarchi R. Immunization against foot-and-mouth disease with synthetic peptides representing the C-terminal region of VP1. The Journal of General Virology. 69: 2403-6. PMID 2457649 DOI: 10.1099/0022-1317-69-9-2403 |
0.398 |
|
| 1986 |
DiMarchi R, Brooke G, Gale C, Cracknell V, Doel T, Mowat N. Protection of cattle against foot-and-mouth disease by a synthetic peptide. Science (New York, N.Y.). 232: 639-41. PMID 3008333 DOI: 10.1126/Science.3008333 |
0.372 |
|
| 1983 |
Voss C, Dimarchi R, Whitney DB, Tjoeng FS, Merrifield RB, Tam JP. Synthesis of the protected tridecapeptide (56-68) of the VH domain of mouse myeloma immunoglobulin M603 and its reattachment to resin supports. International Journal of Peptide and Protein Research. 22: 204-13. PMID 6618764 DOI: 10.1111/J.1399-3011.1983.Tb02087.X |
0.581 |
|
| 1982 |
Dimarchi RD, Tam JP, Kent SB, Merrifield RB. Weak acid-catalyzed pyrrolidone carboxylic acid formation from glutamine during solid phase peptide synthesis. Minimization by rapid coupling. International Journal of Peptide and Protein Research. 19: 88-93. PMID 7118385 DOI: 10.1111/J.1399-3011.1982.Tb03027.X |
0.609 |
|
| 1982 |
Dimarchi RD, Tam JP, Merrifield RB. Solid phase synthesis of the protected 43-55 tridecapeptide of the heavy chain of myeloma immunoglobin M603, employing cyclohexyl ester protection for glutamic acid. International Journal of Peptide and Protein Research. 19: 270-9. PMID 6811468 DOI: 10.1111/j.1399-3011.1982.tb03038.x |
0.52 |
|
| 1981 |
Tam JP, DiMarchi RD, Merrifield RB. Design and synthesis of a multi-detachable benzhydrylamine-resin for solid phase peptide synthesis Tetrahedron Letters. 22: 2851-2854. DOI: 10.1016/S0040-4039(01)81767-6 |
0.505 |
|
| 1980 |
Tam JP, Dimarchi RD, Merrifield RB. Photolabile multi-detachable p-alkoxybenzyl alcohol resin supports for peptide fragment or semi-synthesis. International Journal of Peptide and Protein Research. 16: 412-25. PMID 7216616 DOI: 10.1111/j.1399-3011.1980.tb02965.x |
0.537 |
|
| 1978 |
DiMarchi RD, Garner WH, Wang CC, Hanania GI, Gurd FR. Characterization of the reaction of methyl acetimidate with sperm whale myoglobin. Biochemistry. 17: 2822-8. PMID 28745 |
0.565 |
|
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