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Yi-Ming Chiang - Publications

Affiliations: 
Chemistry University of Southern California, Los Angeles, CA, United States 
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dunbar KL, Perlatti B, Liu N, Cornelius A, Mummau D, Chiang YM, Hon L, Nimavat M, Pallas J, Kordes S, Ng HL, Harvey CJB. Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. Proceedings of the National Academy of Sciences of the United States of America. 120: e2310522120. PMID 37983497 DOI: 10.1073/pnas.2310522120  0.385
2023 Lin SY, Oakley CE, Jenkinson CB, Chiang YM, Lee CK, Jones CG, Seidler PM, Nelson HM, Todd RB, Wang CCC, Oakley BR. A heterologous expression platform in for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the sartorypyrone biosynthetic pathway. Chemical Science. 14: 11022-11032. PMID 37860661 DOI: 10.1039/d3sc02226a  0.482
2023 Rabot C, Chen Y, Lin SY, Miller B, Chiang YM, Oakley CE, Oakley BR, Wang CCC, Williams TJ. Polystyrene Upcycling into Fungal Natural Products and a Biocontrol Agent. Journal of the American Chemical Society. PMID 36779837 DOI: 10.1021/jacs.2c12285  0.776
2022 Rabot C, Chen Y, Bijlani S, Chiang YM, Oakley CE, Oakley BR, Williams TJ, Wang CCC. Conversion of Polyethylenes into Fungal Secondary Metabolites. Angewandte Chemie (International Ed. in English). e202214609. PMID 36417558 DOI: 10.1002/anie.202214609  0.762
2022 Chiang YM, Lin TS, Wang CCC. Total Heterologous Biosynthesis of Fungal Natural Products in . Journal of Natural Products. PMID 36173392 DOI: 10.1021/acs.jnatprod.2c00487  0.743
2022 Sun WW, Li CY, Chiang YM, Lin TS, Warren S, Chang FR, Wang CCC. Characterization of a silent azaphilone biosynthesis gene cluster in Aspergillus terreus NIH 2624. Fungal Genetics and Biology : Fg & B. 160: 103694. PMID 35398258 DOI: 10.1016/j.fgb.2022.103694  0.847
2021 Lim S, Bijlani S, Blachowicz A, Chiang YM, Lee MS, Torok T, Venkateswaran K, C C Wang C. Identification of the pigment and its role in UV resistance in Paecilomyces variotii, a Chernobyl isolate, using genetic manipulation strategies. Fungal Genetics and Biology : Fg & B. 103567. PMID 33989788 DOI: 10.1016/j.fgb.2021.103567  0.78
2020 Chiang YM, Lin TS, Chang SL, Ahn G, Wang CCC. An Platform for the Complete Cluster Refactoring and Total Biosynthesis of Fungal Natural Products. Acs Synthetic Biology. PMID 33375785 DOI: 10.1021/acssynbio.0c00536  0.702
2020 Romsdahl J, Blachowicz A, Chiang YM, Venkateswaran K, Wang CCC. Metabolomic Analysis of Isolated From the International Space Station Reveals Enhanced Production Levels of the Antioxidant Pyranonigrin A. Frontiers in Microbiology. 11: 931. PMID 32670208 DOI: 10.3389/Fmicb.2020.00931  0.817
2019 Lin T, Chen B, Chiang Y, Wang CCC. Front Cover: Discovery and Elucidation of the Biosynthesis of Aspernidgulenes: Novel Polyenes from Aspergillus Nidulans by Using Serial Promoter Replacement (ChemBioChem 3/2019) Chembiochem. 20: 308-308. DOI: 10.1002/Cbic.201900007  0.711
2018 Romsdahl J, Blachowicz A, Chiang AJ, Chiang YM, Masonjones S, Yaegashi J, Countryman S, Karouia F, Kalkum M, Stajich JE, Venkateswaran K, Wang CCC. International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans. Applied Microbiology and Biotechnology. PMID 30539259 DOI: 10.1007/S00253-018-9525-0  0.776
2018 Grau MF, Entwistle R, Chiang YM, Ahuja M, Oakley CE, Akashi T, Wang CCC, Todd RB, Oakley BR. Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans. Acs Chemical Biology. PMID 30339758 DOI: 10.1021/Acschembio.8B00679  0.813
2018 Lin TS, Chen B, Chiang YM, Wang C. Discovery and elucidation of the biosynthesis of aspernidgulenes, novel polyenes from Aspergillus nidulans, using serial promoter replacement. Chembiochem : a European Journal of Chemical Biology. PMID 30302871 DOI: 10.1002/Cbic.201800486  0.758
2018 Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H. Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition. Hepatology (Baltimore, Md.). PMID 29729190 DOI: 10.1002/Hep.30071  0.355
2017 Sung CT, Chang SL, Entwistle R, Ahn G, Lin TS, Petrova V, Yeh HH, Praseuth MB, Chiang YM, Oakley BR, Wang CC. Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan. Fungal Genetics and Biology : Fg & B. PMID 28108400 DOI: 10.1016/J.Fgb.2017.01.006  0.794
2016 Yaegashi J, Romsdahl J, Chiang YM, Wang CCC. Correction: Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in . Chemical Science. 7: 2440. PMID 30123464 DOI: 10.1039/c6sc90012g  0.795
2016 Oakley CE, Ahuja M, Sun WW, Entwistle R, Akashi T, Yaegashi J, Guo CJ, Cerqueira GC, Wortman JR, Wang CC, Chiang YM, Oakley BR. Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Molecular Microbiology. PMID 27775185 DOI: 10.1111/Mmi.13562  0.827
2016 Yeh HH, Ahuja M, Chiang YM, Oakley CE, Moore S, Yoon O, Hajovsky H, Bok JW, Keller NP, Wang CC, Oakley BR. Resistance gene-guided genome mining: Serial promoter exchanges in Aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, a proteasome inhibitor. Acs Chemical Biology. PMID 27294372 DOI: 10.1021/Acschembio.6B00213  0.627
2016 Lin TS, Chiang YM, Wang CC. Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans. Organic Letters. PMID 26954888 DOI: 10.1021/Acs.Orglett.6B00299  0.789
2016 Yang FC, Chen YL, Tang SL, Yu CP, Wang PH, Ismail W, Wang CH, Ding JY, Yang CY, Yang CY, Chiang YR. Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment. The Isme Journal. PMID 26872041 DOI: 10.1038/ismej.2015.255  0.344
2016 Yaegashi J, Romsdahl J, Chiang YM, Wang CCC. Correction: Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens (Chem. Sci. (2015) 6 (6537-6544)) Chemical Science. 7: 2440. DOI: 10.1039/c6sc90012g  0.361
2015 Yaegashi J, Romsdahl J, Chiang YM, Wang CCC. Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in . Chemical Science. 6: 6537-6544. PMID 30090271 DOI: 10.1039/C5Sc01965F  0.833
2015 Chiang YM, Ahuja M, Oakley CE, Entwistle R, Asokan A, Zutz C, Wang CC, Oakley BR. Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin. Angewandte Chemie (International Ed. in English). PMID 26563584 DOI: 10.1002/Anie.201507097  0.662
2015 Yaegashi J, Romsdahl J, Chiang YM, Wang CCC. Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens Chemical Science. 6: 6537-6544. DOI: 10.1039/c5sc01965f  0.367
2014 Liu T, Sanchez JF, Chiang YM, Oakley BR, Wang CC. Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases. Organic Letters. 16: 1676-9. PMID 24593241 DOI: 10.1021/Ol5003384  0.652
2014 Paranjape SR, Chiang YM, Sanchez JF, Entwistle R, Wang CC, Oakley BR, Gamblin TC. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta Medica. 80: 77-85. PMID 24414310 DOI: 10.1055/S-0033-1360180  0.646
2014 Chiang YM, Wang CCC, Oakley BR. Analyzing Fungal Secondary Metabolite Genes and Gene Clusters Natural Products: Discourse, Diversity, and Design. 171-193. DOI: 10.1002/9781118794623.ch10  0.404
2013 Bok JW, Soukup AA, Chadwick E, Chiang YM, Wang CC, Keller NP. VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Molecular Microbiology. 89: 963-74. PMID 23841751 DOI: 10.1111/Mmi.12326  0.618
2013 Guo CJ, Knox BP, Sanchez JF, Chiang YM, Bruno KS, Wang CC. Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Organic Letters. 15: 3562-5. PMID 23841722 DOI: 10.1021/Ol401384V  0.78
2013 Yaegashi J, Praseuth MB, Tyan SW, Sanchez JF, Entwistle R, Chiang YM, Oakley BR, Wang CC. Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans. Organic Letters. 15: 2862-5. PMID 23706169 DOI: 10.1021/Ol401187B  0.824
2013 Chiang YM, Oakley CE, Ahuja M, Entwistle R, Schultz A, Chang SL, Sung CT, Wang CC, Oakley BR. An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. Journal of the American Chemical Society. 135: 7720-31. PMID 23621425 DOI: 10.1021/Ja401945A  0.646
2013 Guo CJ, Yeh HH, Chiang YM, Sanchez JF, Chang SL, Bruno KS, Wang CC. Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. Journal of the American Chemical Society. 135: 7205-13. PMID 23586797 DOI: 10.1021/Ja3123653  0.819
2013 Chang SL, Chiang YM, Yeh HH, Wu TK, Wang CC. Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC. Bioorganic & Medicinal Chemistry Letters. 23: 2155-7. PMID 23434416 DOI: 10.1016/J.Bmcl.2013.01.099  0.515
2013 Yeh HH, Chang SL, Chiang YM, Bruno KS, Oakley BR, Wu TK, Wang CC. Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping. Organic Letters. 15: 756-9. PMID 23368695 DOI: 10.1021/Ol303328T  0.458
2013 Yin WB, Reinke AW, Szilágyi M, Emri T, Chiang YM, Keating AE, Pócsi I, Wang CC, Keller NP. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading, England). 159: 77-88. PMID 23154967 DOI: 10.1099/Mic.0.063370-0  0.421
2012 Guo CJ, Knox BP, Chiang YM, Lo HC, Sanchez JF, Lee KH, Oakley BR, Bruno KS, Wang CC. Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters. 14: 5684-7. PMID 23116177 DOI: 10.1021/Ol302682Z  0.848
2012 Soukup AA, Chiang YM, Bok JW, Reyes-Dominguez Y, Oakley BR, Wang CC, Strauss J, Keller NP. Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production. Molecular Microbiology. 86: 314-30. PMID 22882998 DOI: 10.1111/J.1365-2958.2012.08195.X  0.594
2012 Yeh HH, Chiang YM, Entwistle R, Ahuja M, Lee KH, Bruno KS, Wu TK, Oakley BR, Wang CC. Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis. Applied Microbiology and Biotechnology. 96: 739-48. PMID 22627757 DOI: 10.1007/S00253-012-4098-9  0.606
2012 Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. Journal of the American Chemical Society. 134: 8212-21. PMID 22510154 DOI: 10.1021/Ja3016395  0.8
2012 Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC. Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans. Journal of the American Chemical Society. 134: 4709-20. PMID 22329759 DOI: 10.1021/Ja209809T  0.825
2012 Somoza AD, Lee KH, Chiang YM, Oakley BR, Wang CC. Reengineering an azaphilone biosynthesis pathway in Aspergillus nidulans to create lipoxygenase inhibitors. Organic Letters. 14: 972-5. PMID 22296232 DOI: 10.1021/Ol203094K  0.808
2012 Yin WB, Amaike S, Wohlbach DJ, Gasch AP, Chiang YM, Wang CC, Bok JW, Rohlfs M, Keller NP. An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Molecular Microbiology. 83: 1024-34. PMID 22283524 DOI: 10.1111/J.1365-2958.2012.07986.X  0.57
2012 Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology (Baltimore, Md.). 55: 1271-81. PMID 22095555 DOI: 10.1002/Hep.24792  0.443
2011 Liu T, Chiang YM, Somoza AD, Oakley BR, Wang CC. Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. Journal of the American Chemical Society. 133: 13314-6. PMID 21815681 DOI: 10.1021/Ja205780G  0.779
2011 Sanchez JF, Entwistle R, Hung JH, Yaegashi J, Jain S, Chiang YM, Wang CC, Oakley BR. Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. Journal of the American Chemical Society. 133: 4010-7. PMID 21351751 DOI: 10.1021/Ja1096682  0.846
2011 Chiang YM, Meyer KM, Praseuth M, Baker SE, Bruno KS, Wang CC. Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone. Fungal Genetics and Biology : Fg & B. 48: 430-7. PMID 21176790 DOI: 10.1016/J.Fgb.2010.12.001  0.623
2011 Chiang YM, Chang SL, Oakley BR, Wang CC. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Current Opinion in Chemical Biology. 15: 137-43. PMID 21111669 DOI: 10.1016/J.Cbpa.2010.10.011  0.643
2010 Chiang YM, Oakley BR, Keller NP, Wang CC. Unraveling polyketide synthesis in members of the genus Aspergillus. Applied Microbiology and Biotechnology. 86: 1719-36. PMID 20361326 DOI: 10.1007/S00253-010-2525-3  0.509
2010 Sanchez JF, Chiang YM, Szewczyk E, Davidson AD, Ahuja M, Elizabeth Oakley C, Woo Bok J, Keller N, Oakley BR, Wang CC. Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Molecular Biosystems. 6: 587-93. PMID 20174687 DOI: 10.1039/B904541D  0.728
2010 Wang CC, Chiang YM, Praseuth MB, Kuo PL, Liang HL, Hsu YL. Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. Basic & Clinical Pharmacology & Toxicology. 107: 583-9. PMID 20148857 DOI: 10.1111/J.1742-7843.2010.00545.X  0.429
2010 Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR. Characterization of the Aspergillus nidulans monodictyphenone gene cluster. Applied and Environmental Microbiology. 76: 2067-74. PMID 20139316 DOI: 10.1128/Aem.02187-09  0.653
2009 Chiang YM, Lee KH, Sanchez JF, Keller NP, Wang CC. Unlocking fungal cryptic natural products. Natural Product Communications. 4: 1505-10. PMID 19967983 DOI: 10.1177/1934578X0900401113  0.719
2009 Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP. Chromatin-level regulation of biosynthetic gene clusters. Nature Chemical Biology. 5: 462-4. PMID 19448638 DOI: 10.1038/Nchembio.177  0.787
2009 Chiang YM, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang CC. A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. Journal of the American Chemical Society. 131: 2965-70. PMID 19199437 DOI: 10.1021/Ja8088185  0.7
2009 Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CCC, Keller NP. Chromatin-level regulation of biosynthetic gene clusters (Nature Chemical Biology (2009) 5, (462-464)) Nature Chemical Biology. 5: 696. DOI: 10.1038/Nchembio0909-696A  0.72
2008 Szewczyk E, Chiang YM, Oakley CE, Davidson AD, Wang CC, Oakley BR. Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. Applied and Environmental Microbiology. 74: 7607-12. PMID 18978088 DOI: 10.1128/Aem.01743-08  0.677
2008 Wang CC, Chiang YM, Kuo PL, Chang JK, Hsu YL. Norsolorinic acid inhibits proliferation of T24 human bladder cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas/membrane-bound Fas ligand-mediated apoptotic pathway. Clinical and Experimental Pharmacology & Physiology. 35: 1301-8. PMID 18671724 DOI: 10.1111/J.1440-1681.2008.05007.X  0.42
2008 Chiang YM, Szewczyk E, Nayak T, Davidson AD, Sanchez JF, Lo HC, Ho WY, Simityan H, Kuo E, Praseuth A, Watanabe K, Oakley BR, Wang CC. Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chemistry & Biology. 15: 527-32. PMID 18559263 DOI: 10.1016/J.Chembiol.2008.05.010  0.828
2008 Wang CC, Chiang YM, Kuo PL, Chang JK, Hsu YL. Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway. Basic & Clinical Pharmacology & Toxicology. 102: 491-7. PMID 18346044 DOI: 10.1111/J.1742-7843.2008.00237.X  0.435
2008 Sanchez JF, Chiang YM, Wang CC. Diversity of polyketide synthases found in the Aspergillus and Streptomyces genomes. Molecular Pharmaceutics. 5: 226-33. PMID 18338869 DOI: 10.1021/Mp700139T  0.696
2008 Wang CC, Chiang YM, Sung SC, Hsu YL, Chang JK, Kuo PL. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Letters. 259: 82-98. PMID 18023967 DOI: 10.1016/J.Canlet.2007.10.005  0.436
2003 Chiang YM, Liu HK, Lo JM, Chien SC, Chan YF, Lee TH, Su JK, Kuo YH. Cytotoxic constituents of the leaves of Calocedrus formosana Journal of the Chinese Chemical Society. 50: 161-166. DOI: 10.1002/Jccs.200300022  0.325
2001 Kuo YH, Chen CH, Chiang YM. Three novel and one new lignan, chamaecypanones A, B, obtulignolide and isootobanone from the heartwood of Chamaecyparis obtusa var. formosana Tetrahedron Letters. 42: 6731-6735. DOI: 10.1016/S0040-4039(01)01272-2  0.303
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