| Year |
Citation |
Score |
| 2023 |
Figg WD, Fiorini G, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2. Proteins. PMID 37449559 DOI: 10.1002/prot.26541 |
0.643 |
|
| 2023 |
Miura T, Malla TR, Owen CD, Tumber A, Brewitz L, McDonough MA, Salah E, Terasaka N, Katoh T, Lukacik P, Strain-Damerell C, Mikolajek H, Walsh MA, Kawamura A, Schofield CJ, et al. In vitro selection of macrocyclic peptide inhibitors containing cyclic γ-amino acids targeting the SARS-CoV-2 main protease. Nature Chemistry. PMID 37217786 DOI: 10.1038/s41557-023-01205-1 |
0.587 |
|
| 2022 |
Li Z, Wu Y, Zhen S, Su K, Zhang L, Yang F, McDonough M, Schofield C, Zhang X. In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. Angewandte Chemie (International Ed. in English). PMID 36112310 DOI: 10.1002/anie.202211510 |
0.402 |
|
| 2022 |
Kaur S, Tam NY, McDonough MA, Schofield CJ, Aik WS. Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Research. 50: 4148-4160. PMID 35333330 DOI: 10.1093/nar/gkac195 |
0.43 |
|
| 2022 |
Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2. Antibiotics (Basel, Switzerland). 11. PMID 35326858 DOI: 10.3390/antibiotics11030396 |
0.4 |
|
| 2021 |
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, ... ... McDonough MA, et al. Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature Chemistry. PMID 34903857 DOI: 10.1038/s41557-021-00831-x |
0.787 |
|
| 2021 |
Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, et al. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. Journal of Medicinal Chemistry. PMID 34762429 DOI: 10.1021/acs.jmedchem.1c01204 |
0.523 |
|
| 2021 |
Islam MS, Thinnes C, Holt-Martyn J, Chowdhury R, McDonough M, Schofield C. Inhibition of JMJD6 by 2-Oxoglutarate Mimics. Chemmedchem. PMID 34581506 DOI: 10.1002/cmdc.202100398 |
0.61 |
|
| 2021 |
Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, et al. X-ray free-electron laser studies reveal correlated motion during isopenicillin synthase catalysis. Science Advances. 7. PMID 34417180 DOI: 10.1126/sciadv.abh0250 |
0.619 |
|
| 2021 |
Wu Y, Li Z, McDonough MA, Schofield CJ, Zhang X. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. Journal of Medicinal Chemistry. PMID 34029087 DOI: 10.1021/acs.jmedchem.1c00415 |
0.488 |
|
| 2021 |
Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield C. Human oxygenase variants employing a single protein Fe(II) ligand are catalytically active. Angewandte Chemie (International Ed. in English). PMID 33887099 DOI: 10.1002/anie.202103711 |
0.623 |
|
| 2021 |
Figg WD, McDonough MA, Chowdhury R, Nakashima YA, Zhang ZA, Holt-Martyn JP, Krajnc A, Schofield C. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem. PMID 33792169 DOI: 10.1002/cmdc.202100133 |
0.677 |
|
| 2021 |
Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Faropenem reacts with serine and metallo-β-lactamases to give multiple products. European Journal of Medicinal Chemistry. 215: 113257. PMID 33618159 DOI: 10.1016/j.ejmech.2021.113257 |
0.696 |
|
| 2021 |
Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, ... ... McDonough MA, et al. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature Communications. 12: 891. PMID 33563959 DOI: 10.1038/s41467-020-20670-7 |
0.413 |
|
| 2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, et al. A human protein hydroxylase that accepts D-residues. Communications Chemistry. 3: 52. PMID 36703414 DOI: 10.1038/s42004-020-0290-5 |
0.771 |
|
| 2020 |
Brewitz L, Tumber A, Pfeffer I, McDonough MA, Schofield CJ. Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors. Scientific Reports. 10: 22398. PMID 33349651 DOI: 10.1038/s41598-020-80008-7 |
0.402 |
|
| 2020 |
Li Z, Zhen S, Su K, Tumber A, Yu Q, Dong Y, McDonough M, Schofield CJ, Zhang X. A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation. Chemical Communications (Cambridge, England). PMID 33111730 DOI: 10.1039/d0cc06353c |
0.46 |
|
| 2020 |
Rabe P, Beale JH, Butryn A, Aller P, Dirr A, Lang PA, Axford DN, Carr SB, Leissing TM, McDonough MA, Davy B, Ebrahim A, Orlans J, Storm SLS, Orville AM, et al. Anaerobic fixed-target serial crystallography. Iucrj. 7: 901-912. PMID 32939282 DOI: 10.1107/S2052252520010374 |
0.372 |
|
| 2020 |
Liu T, Abboud MI, Chowdhury R, Tumber A, Hardy AP, Lippl K, Lohans CT, Pires E, Wickens J, McDonough MA, West CM, Schofield CJ. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry. PMID 32934009 DOI: 10.1074/Jbc.Ra120.013998 |
0.81 |
|
| 2020 |
Brewitz L, Tumber A, Pfeffer I, McDonough MA, Schofield CJ. Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors. Scientific Reports. 10: 8650. PMID 32457455 DOI: 10.1038/S41598-020-65123-9 |
0.496 |
|
| 2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, et al. A human protein hydroxylase that accepts D-residues Communications Chemistry. 3. DOI: 10.1038/s42004-020-0290-5 |
0.576 |
|
| 2019 |
Parkova A, Lucic A, Krajnc A, Brem J, Calvopina K, Langley G, McDonough MA, Trapencieris P, Schofield CJ. Broad Spectrum β-lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Acs Infectious Diseases. PMID 31841636 DOI: 10.1021/acsinfecdis.9b00330 |
0.415 |
|
| 2019 |
Holt-Martyn J, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans C, Langley G, McDonough M, Pugh C, Ratcliffe P, Schofield C. Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem. PMID 31751494 DOI: 10.1002/Cmdc.201900557 |
0.772 |
|
| 2019 |
Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature Communications. 10: 4910. PMID 31659163 DOI: 10.1038/S41467-019-12711-7 |
0.464 |
|
| 2019 |
Li G, Su Y, Yan YH, Peng JY, Dai QQ, Ning XL, Zhu CL, Fu C, McDonough MA, Schofield CJ, Huang C, Li GB. MeLAD: an integrated resource for metalloenzyme-ligand associations. Bioinformatics (Oxford, England). PMID 31504189 DOI: 10.1093/Bioinformatics/Btz648 |
0.34 |
|
| 2019 |
Islam MS, McDonough MA, Chowdhury R, Gault J, Khan A, Pires E, Schofield CJ. Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of Biological Chemistry. PMID 31147442 DOI: 10.1074/Jbc.Ra119.008693 |
0.651 |
|
| 2019 |
Holt-Martyn JP, Tumber A, Rahman MZ, Lippl K, Figg W, McDonough MA, Chowdhury R, Schofield CJ. Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm. 10: 500-504. PMID 31057728 DOI: 10.1039/C8Md00548F |
0.649 |
|
| 2019 |
Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. Biochimica Et Biophysica Acta. General Subjects. PMID 30738906 DOI: 10.1016/J.Bbagen.2019.02.004 |
0.685 |
|
| 2018 |
Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal . Hypoxia (Auckland, N.Z.). 6: 57-71. PMID 30519597 DOI: 10.2147/Hp.S174655 |
0.748 |
|
| 2018 |
Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. Elife. 7. PMID 30507380 DOI: 10.7554/Elife.39865 |
0.408 |
|
| 2018 |
Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Crystal Structures of VIM-1 Complexes Explain Active Site Heterogeneity in VIM-Class Metallo-β-Lactamases. The Febs Journal. PMID 30430727 DOI: 10.1111/Febs.14695 |
0.499 |
|
| 2018 |
Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases. Bioorganic & Medicinal Chemistry. PMID 29655609 DOI: 10.1016/J.Bmc.2018.02.043 |
0.796 |
|
| 2018 |
Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. YcfDis a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase. Extremophiles : Life Under Extreme Conditions. PMID 29523972 DOI: 10.1007/S00792-018-1016-9 |
0.694 |
|
| 2018 |
Zhang C, Pu Y, Yu Z, Wu C, Brem J, McDonough MA, Schofield CJ, Li G, Wu Y. Rh(iii)-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases Organic Chemistry Frontiers. 5: 1288-1292. DOI: 10.1039/C8Qo00009C |
0.398 |
|
| 2017 |
Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh P, Schofield CJ, Fishwick CWG. In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors. Journal of Medicinal Chemistry. PMID 29271657 DOI: 10.1021/Acs.Jmedchem.7B01728 |
0.507 |
|
| 2017 |
Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ. (13)C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. Organic & Biomolecular Chemistry. PMID 28678295 DOI: 10.1039/C7Ob01514C |
0.776 |
|
| 2017 |
Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. Chemical Communications (Cambridge, England). PMID 28470248 DOI: 10.1039/C7Cc02394D |
0.801 |
|
| 2017 |
Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ. NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors. Chemical Science. 8: 928-937. PMID 28451231 DOI: 10.1039/C6Sc04524C |
0.728 |
|
| 2017 |
Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proceedings of the National Academy of Sciences of the United States of America. PMID 28420789 DOI: 10.1073/Pnas.1617760114 |
0.691 |
|
| 2017 |
Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cyclic Boronates Inhibit All Classes of β-Lactamase. Antimicrobial Agents and Chemotherapy. PMID 28115348 DOI: 10.1128/Aac.02260-16 |
0.708 |
|
| 2017 |
Abuhammad A, McDonough MA, Brem J, Makena A, Johnson S, Schofield CJ, Garman EF. “To Cross-Seed or Not To Cross-Seed”: A Pilot Study Using Metallo-β-lactamases Crystal Growth & Design. 17: 913-924. DOI: 10.1021/Acs.Cgd.6B01805 |
0.376 |
|
| 2016 |
Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications. 7: 12406. PMID 27499424 DOI: 10.1038/Ncomms12406 |
0.663 |
|
| 2016 |
Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J. Use of ferrous iron by metallo-β-lactamases. Journal of Inorganic Biochemistry. PMID 27498591 DOI: 10.1016/J.Jinorgbio.2016.07.013 |
0.416 |
|
| 2016 |
Khan A, Leśniak RK, Brem J, Rydzik AM, Choi H, Leung IKH, McDonough MA, Schofield CJ, Claridge TDW. Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase Medchemcomm. 7: 873-880. DOI: 10.1039/C6Md00004E |
0.766 |
|
| 2016 |
Kamps JJAG, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TDW, Mecinović J. Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis Chemistry - a European Journal. 22. DOI: 10.1002/Chem.201680462 |
0.769 |
|
| 2015 |
Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ. Comparison of Verona Integron-Borne Metallo-β-lactamase Variants Reveals Differences in Stability and Inhibition Profiles. Antimicrobial Agents and Chemotherapy. PMID 26666919 DOI: 10.1128/Aac.01768-15 |
0.444 |
|
| 2015 |
Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26660433 DOI: 10.1002/Chem.201503761 |
0.793 |
|
| 2015 |
Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers. Antimicrobial Agents and Chemotherapy. PMID 26482303 DOI: 10.1128/Aac.01335-15 |
0.476 |
|
| 2015 |
Daoud H, Zhang D, McMurray F, Yu A, Luco SM, Vanstone J, Jarinova O, Carson N, Wickens J, Shishodia S, Choi H, McDonough MA, Schofield CJ, Harper ME, Dyment DA, et al. Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay. Journal of Medical Genetics. PMID 26378117 DOI: 10.1136/Jmedgenet-2015-103399 |
0.324 |
|
| 2015 |
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. Pharmacological inhibition of FTO. Plos One. 10: e0121829. PMID 25830347 DOI: 10.1371/Journal.Pone.0121829 |
0.38 |
|
| 2015 |
Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure (London, England : 1993). 23: 639-52. PMID 25728928 DOI: 10.1016/J.Str.2015.01.014 |
0.768 |
|
| 2015 |
Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, (19)F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file. Chemical Science (Royal Society of Chemistry : 2010). 6: 956-963. PMID 25717359 DOI: 10.1039/C4Sc01752H |
0.415 |
|
| 2015 |
Pettinati I, Brem J, McDonough MA, Schofield CJ. Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Human Molecular Genetics. 24: 2458-69. PMID 25596185 DOI: 10.1093/Hmg/Ddv007 |
0.482 |
|
| 2015 |
Aik WS, Chowdhury R, Clifton IJ, Hopkinson RJ, Leissing T, McDonough MA, Nowak R, Schofield CJ, Walport LJ. Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes Rsc Metallobiology. 2015: 59-94. DOI: 10.1039/9781782621959-00059 |
0.709 |
|
| 2014 |
Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. Chemical Science (Royal Society of Chemistry : 2010). 5: 1765-1771. PMID 26682037 DOI: 10.1039/C4Sc00020J |
0.727 |
|
| 2014 |
Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nature Chemistry. 6: 1084-90. PMID 25411887 DOI: 10.1038/Nchem.2110 |
0.634 |
|
| 2014 |
Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, Horita S, Ho CH, Kershaw NJ, ... ... McDonough MA, et al. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 13331-6. PMID 25197067 DOI: 10.1073/Pnas.1409916111 |
0.497 |
|
| 2014 |
Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids. Angewandte Chemie (International Ed. in English). 53: 10925-7. PMID 25164544 DOI: 10.1002/Anie.201406125 |
0.352 |
|
| 2014 |
Rydzik AM, Leung IK, Kochan GT, Loik ND, Henry L, McDonough MA, Claridge TD, Schofield CJ. Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase. Organic & Biomolecular Chemistry. 12: 6354-8. PMID 25030770 DOI: 10.1039/C4Ob01167H |
0.438 |
|
| 2014 |
Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, ... ... McDonough MA, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 510: 422-6. PMID 24814345 DOI: 10.1038/Nature13263 |
0.748 |
|
| 2014 |
Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America. 111: 4019-24. PMID 24550462 DOI: 10.1073/Pnas.1311750111 |
0.799 |
|
| 2014 |
Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA. Structure of human RNA Nâ¶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Research. 42: 4741-54. PMID 24489119 DOI: 10.1093/Nar/Gku085 |
0.478 |
|
| 2014 |
Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/C3Cc48151D |
0.415 |
|
| 2014 |
Horita S, Scotti J, McDonough M, Sekirnik R, Chowdhury R, Krojer T, Thalhammer A, Aik W, Oppermann U, Schofield C. Crystal structures of 2OG oxygenases involved in ribosomal protein hydroxylation Acta Crystallographica Section a Foundations and Advances. 70: C304-C304. DOI: 10.1107/S2053273314096958 |
0.51 |
|
| 2014 |
Abuhammad A, McDonough M, Brem J, Schofield C, Garman E. "From one seed a whole handful": homologous proteins as seeds in crystallisation Acta Crystallographica Section a Foundations and Advances. 70: C1144-C1144. DOI: 10.1107/S205327331408855X |
0.446 |
|
| 2014 |
Aik WS, Demetriades M, Schofield C, McDonough M. Structures of human m6A RNA demethylases: FTO and ALKBH5 Acta Crystallographica Section a Foundations and Advances. 70: C1392-C1392. DOI: 10.1107/S2053273314086070 |
0.48 |
|
| 2014 |
Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis-selective inhibition of γ-butyrobetaine hydroxylase Chemical Science. 5: 1765-1771. DOI: 10.1039/c4sc00020j |
0.665 |
|
| 2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... McDonough MA, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G |
0.811 |
|
| 2013 |
van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. Binding of (5S)-penicilloic acid to penicillin binding protein 3. Acs Chemical Biology. 8: 2112-6. PMID 23899657 DOI: 10.1021/Cb400200H |
0.463 |
|
| 2013 |
Valegård K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA. Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica. Section D, Biological Crystallography. 69: 1567-79. PMID 23897479 DOI: 10.1107/S0907444913011013 |
0.437 |
|
| 2013 |
Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/Cb400088Q |
0.764 |
|
| 2013 |
Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, Lejeune C, Zhang Z, McDonough MA, Schofield CJ. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). Journal of Medicinal Chemistry. 56: 3680-8. PMID 23547775 DOI: 10.1021/Jm400193D |
0.643 |
|
| 2013 |
Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4. PMID 23296631 DOI: 10.1002/Anie.201208046 |
0.711 |
|
| 2013 |
Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ. The enzymes of β-lactam biosynthesis. Natural Product Reports. 30: 21-107. PMID 23135477 DOI: 10.1039/C2Np20065A |
0.65 |
|
| 2013 |
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... McDonough MA, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g |
0.779 |
|
| 2012 |
Aik W, McDonough MA, Thalhammer A, Chowdhury R, Schofield CJ. Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Current Opinion in Structural Biology. 22: 691-700. PMID 23142576 DOI: 10.1016/J.Sbi.2012.10.001 |
0.64 |
|
| 2012 |
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, ... ... McDonough MA, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J |
0.793 |
|
| 2012 |
Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6672-5. PMID 22639232 DOI: 10.1002/Anie.201202000 |
0.758 |
|
| 2012 |
Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. Journal of Medicinal Chemistry. 55: 2173-84. PMID 22263962 DOI: 10.1021/Jm201417E |
0.74 |
|
| 2012 |
Mantri M, Zhang Z, McDonough MA, Schofield CJ. Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases. The Febs Journal. 279: 1563-75. PMID 22251775 DOI: 10.1111/J.1742-4658.2012.08496.X |
0.428 |
|
| 2012 |
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International Ed. in English). 51: 1631-4. PMID 22241642 DOI: 10.1002/Anie.201107833 |
0.794 |
|
| 2012 |
Mantri M, Webby CJ, Loik ND, Hamed RB, Nielsen ML, McDonough MA, McCullagh JSO, Böttger A, Schofield CJ, Wolf A. Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 Medchemcomm. 3: 80-85. DOI: 10.1039/C1Md00225B |
0.691 |
|
| 2011 |
Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ. Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). Journal of Molecular Biology. 410: 268-79. PMID 21601578 DOI: 10.1016/J.Jmb.2011.04.075 |
0.703 |
|
| 2011 |
Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochemical and Biophysical Research Communications. 408: 553-8. PMID 21530488 DOI: 10.1016/J.Bbrc.2011.04.059 |
0.452 |
|
| 2011 |
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43 |
0.764 |
|
| 2011 |
Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/Cmdc.201100026 |
0.814 |
|
| 2011 |
Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Inhibition of 2-oxoglutarate dependent oxygenases. Chemical Society Reviews. 40: 4364-97. PMID 21390379 DOI: 10.1039/C0Cs00203H |
0.761 |
|
| 2011 |
Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/J.1742-4658.2011.08022.X |
0.735 |
|
| 2011 |
Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 286: 7648-60. PMID 21177872 DOI: 10.1074/Jbc.M110.193540 |
0.647 |
|
| 2011 |
Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/Erc-10-0113 |
0.563 |
|
| 2010 |
Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ. Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chemistry & Biology. 17: 1316-24. PMID 21168767 DOI: 10.1016/J.Chembiol.2010.09.016 |
0.474 |
|
| 2010 |
McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Current Opinion in Structural Biology. 20: 659-72. PMID 20888218 DOI: 10.1016/J.Sbi.2010.08.006 |
0.808 |
|
| 2010 |
Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & Medicinal Chemistry Letters. 20: 6125-8. PMID 20822901 DOI: 10.1016/J.Bmcl.2010.08.032 |
0.798 |
|
| 2010 |
Mantri M, Krojer T, Bagg EA, Webby CA, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. Journal of Molecular Biology. PMID 20685276 DOI: 10.1016/J.Jmb.2010.05.054 |
0.463 |
|
| 2010 |
Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. Journal of Molecular Biology. 401: 211-22. PMID 20684070 |
0.46 |
|
| 2010 |
Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/Jm901680B |
0.816 |
|
| 2010 |
Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. Febs Letters. 584: 825-30. PMID 20067792 DOI: 10.1016/J.Febslet.2009.12.055 |
0.742 |
|
| 2010 |
Iqbal A, Arunlanantham H, Brown T, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins. 78: 1398-407. PMID 20014241 DOI: 10.1002/Prot.22653 |
0.732 |
|
| 2009 |
Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (London, England : 1993). 17: 981-9. PMID 19604478 DOI: 10.1016/J.Str.2009.06.002 |
0.792 |
|
| 2009 |
Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Molecular Biosystems. 5: 52-8. PMID 19081931 DOI: 10.1039/B815271C |
0.42 |
|
| 2008 |
Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. Journal of Medicinal Chemistry. 51: 7053-6. PMID 18942826 DOI: 10.1021/Jm800936S |
0.634 |
|
| 2008 |
Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. The Biochemical Journal. 416: 387-94. PMID 18713068 DOI: 10.1042/Bj20081238 |
0.726 |
|
| 2008 |
Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). The Journal of Biological Chemistry. 283: 25971-8. PMID 18611856 DOI: 10.1074/Jbc.M804999200 |
0.718 |
|
| 2008 |
Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. The Journal of Biological Chemistry. 283: 3808-15. PMID 18063574 DOI: 10.1074/Jbc.M707411200 |
0.782 |
|
| 2007 |
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (New York, N.Y.). 318: 1469-72. PMID 17991826 DOI: 10.1126/Science.1151710 |
0.368 |
|
| 2007 |
Schofield CJ, McDonough MA. Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH). Biochemical Society Transactions. 35: 870-5. PMID 17956235 DOI: 10.1042/Bst0350870 |
0.38 |
|
| 2007 |
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, et al. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 448: 87-91. PMID 17589501 DOI: 10.1038/Nature05971 |
0.634 |
|
| 2007 |
Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 282: 24027-38. PMID 17573339 DOI: 10.1074/Jbc.M704102200 |
0.694 |
|
| 2007 |
Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. The Journal of Biological Chemistry. 282: 3293-301. PMID 17135241 DOI: 10.1074/Jbc.M608337200 |
0.695 |
|
| 2006 |
Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proceedings of the National Academy of Sciences of the United States of America. 103: 14767-72. PMID 17003112 DOI: 10.1073/Pnas.0606877103 |
0.477 |
|
| 2006 |
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proceedings of the National Academy of Sciences of the United States of America. 103: 9814-9. PMID 16782814 DOI: 10.1073/Pnas.0601283103 |
0.743 |
|
| 2006 |
Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. Journal of Inorganic Biochemistry. 100: 644-69. PMID 16513174 DOI: 10.1016/J.Jinorgbio.2006.01.024 |
0.648 |
|
| 2005 |
Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. Chemical Communications (Cambridge, England). 5438-40. PMID 16261239 DOI: 10.1039/B510707E |
0.726 |
|
| 2005 |
McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. The Journal of Biological Chemistry. 280: 41101-10. PMID 16186124 DOI: 10.1074/Jbc.M507528200 |
0.44 |
|
| 2005 |
Sleeman MC, Sorensen JL, Batchelar ET, McDonough MA, Schofield CJ. Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis. The Journal of Biological Chemistry. 280: 34956-65. PMID 16096274 DOI: 10.1074/Jbc.M507196200 |
0.624 |
|
| 2005 |
McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. Journal of the American Chemical Society. 127: 7680-1. PMID 15913349 DOI: 10.1021/Ja050841B |
0.773 |
|
| 2005 |
Hewitson KS, Granatino N, Welford RW, McDonough MA, Schofield CJ. Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 363: 807-28; discussion 1. PMID 15901537 DOI: 10.1098/Rsta.2004.1540 |
0.461 |
|
| 2005 |
Flashman E, McDonough MA, Schofield CJ. OS-9: another piece in the HIF complex story. Molecular Cell. 17: 472-3. PMID 15721249 DOI: 10.1016/J.Molcel.2005.02.001 |
0.388 |
|
| 2004 |
Lancaster DE, McDonough MA, Schofield CJ. Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. Biochemical Society Transactions. 32: 943-5. PMID 15506931 DOI: 10.1042/Bst0320943 |
0.439 |
|
| 2004 |
Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. The Biochemical Journal. 383: 429-37. PMID 15239670 DOI: 10.1042/Bj20040735 |
0.486 |
|
| 2003 |
McDonough MA, Schofield CJ. New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria. Chemistry & Biology. 10: 898-900. PMID 14583255 DOI: 10.1016/J.Chembiol.2003.10.002 |
0.448 |
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