Dario Renato Alessi, BSc, PhD

Affiliations: 
1988-1991 School of Biochemistry University of Birmingham, UK, Birmingham, England, United Kingdom 
 1991- College of Life Science University of Dundee, Dundee, Scotland, United Kingdom 
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"Dario Alessi"
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Tovell H, Testa A, Zhou H, et al. (2019) Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader. Acs Chemical Biology
Tovell H, Testa A, Maniaci C, et al. (2019) Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader. Acs Chemical Biology
Dhekne HS, Yanatori I, Gomez RC, et al. (2018) A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. Elife. 7
Wang J, Erazo T, Ferguson FM, et al. (2018) Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Acs Chemical Biology
Härtlova A, Herbst S, Peltier J, et al. (2018) LRRK2 is a negative regulator of phagosome maturation in macrophages. The Embo Journal
Mir R, Tonelli F, Lis P, et al. (2018) The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human. The Biochemical Journal
Malik N, Macartney T, Hornberger A, et al. (2017) Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks. The Biochemical Journal
Lis P, Burel S, Steger M, et al. (2017) Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. The Biochemical Journal
Fan Y, Howden AJ, Sarhan AR, et al. (2017) Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. The Biochemical Journal
Steger M, Diez F, Dhekne HS, et al. (2017) Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 6
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