David Grahame-Smith, MB, BS, PhD
|1960-1966||Medical Unit||St. Mary's Hospital Medical School, London, England, United Kingdom|
|1966-1967||Vanderbilt University, Nashville, TN|
|1967-1971||Medical Unit||St. Mary's Hospital Medical School, London, England, United Kingdom|
|1971-||MRC Clinical Pharmacology Unit||University of Oxford, Oxford, United Kingdom|
Area:Neuropharmacology, Serotonin (5-HT)
Br J Clin Pharmacol. 2012 May; 73(5): 830–832.
David Grahame Grahame-Smith (DGS) was one of the UK's leading clinical pharmacologists. His work on the pharmacology of the neurotransmitter serotonin (5-hydroxytryptamine) began with the identification of a key enzyme in its synthesis and continued over the next 35 years through a series of innovative and elegant experiments on its functions and its roles in depression and the tumours that cause the carcinoid syndrome, on the clinical management of which he was an expert.
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|Vaidya VA, Castro ME, Pei Q, et al. (2001) Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. Neuropharmacology. 40: 48-56|
|Meade TW, Wilkes HC, Kelleher CC, et al. (1998) Thrombosis prevention trial: Randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk Lancet. 351: 233-241|
|Adamson AR, Grahame-Smith DG, Peart WS. (1971) Pharmacological blockade of carcinoid flushing provoked by catecholamines and alcohol. American Heart Journal. 81: 141-2|
|Peart WS, Adamson AR, Grahame-Smith DG. (1969) Pharmacological blockade of carcinoid flushing provoked by catecholamines and alcohol. Lancet (London, England). 2: 595|
|Adamson AR, Grahame-Smith DG, Peart WS, et al. (1969) Pharmacological blockade of carcinoid flushing provoked by catecholamines and alcohol. Lancet (London, England). 2: 293-7|
|Grahame-Smith DG, Peart WS, Ferriman DG. (1965) Carcinoid syndrome. Proceedings of the Royal Society of Medicine. 58: 701-2|
|PEART WS, ROBERTSON JI, GRAHAME-SMITH DG. (1961) Examination of the relationship of renin release to hypertension produced in the rabbit by renal-artery constriction. Circulation Research. 9: 1171-84|