Edwin Thrower - Publications

Affiliations: 
1999-2002 Pharmacology Yale University, New Haven, CT 

15/62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. Plos One. 7: e48465. PMID 23185258 DOI: 10.1371/Journal.Pone.0048465  0.559
2011 Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling. The Journal of Biological Chemistry. 286: 1919-26. PMID 21084290 DOI: 10.1074/Jbc.M110.158329  0.513
2009 Gorelick FS, Thrower E. The acinar cell and early pancreatitis responses. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 7: S10-4. PMID 19896090 DOI: 10.1016/J.Cgh.2009.07.036  0.379
2009 Husain S, Thrower E. Molecular and cellular regulation of pancreatic acinar cell function. Current Opinion in Gastroenterology. 25: 466-71. PMID 19571746 DOI: 10.1097/Mog.0B013E32832Ebfac  0.331
2006 Grant W, Shah A, Thrower E, Husain S. Caerulein-Induced Intracellular Pancreatic Zymogen Activation Is Dependent Upon Calcineurin Pancreas. 33: 464. DOI: 10.1097/00006676-200611000-00095  0.341
2003 Thrower EC, Choe CU, So SH, Jeon SH, Ehrlich BE, Yoo SH. A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. The Journal of Biological Chemistry. 278: 49699-706. PMID 14506248 DOI: 10.1074/Jbc.M309307200  0.657
2003 Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings of the National Academy of Sciences of the United States of America. 100: 2975-80. PMID 12606721 DOI: 10.1073/Pnas.0536590100  0.631
2002 Jiang QX, Thrower EC, Chester DW, Ehrlich BE, Sigworth FJ. Three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution. The Embo Journal. 21: 3575-81. PMID 12110570 DOI: 10.1093/Emboj/Cdf380  0.54
2002 Thrower EC, Park HY, So SH, Yoo SH, Ehrlich BE. Activation of the inositol 1,4,5-trisphosphate receptor by the calcium storage protein chromogranin A. The Journal of Biological Chemistry. 277: 15801-6. PMID 11842082 DOI: 10.1074/Jbc.M110139200  0.659
2001 Koulen P, Thrower EC. Pharmacological modulation of intracellular Ca(2+) channels at the single-channel level. Molecular Neurobiology. 24: 65-86. PMID 11831555 DOI: 10.1385/MN:24:1-3:065  0.426
2001 Thrower EC, Hagar RE, Ehrlich BE. Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators. Trends in Pharmacological Sciences. 22: 580-6. PMID 11698102 DOI: 10.1016/S0165-6147(00)01809-5  0.642
2000 Thrower EC, Mobasheri H, Dargan S, Marius P, Lea EJ, Dawson AP. Interaction of luminal calcium and cytosolic ATP in the control of type 1 inositol (1,4,5)-trisphosphate receptor channels. The Journal of Biological Chemistry. 275: 36049-55. PMID 10956640 DOI: 10.1074/jbc.M000970200  0.673
1999 Thrower EC. Measurement of Ca2+ flux through Ins(1,4,5)P3 receptor-Ca2+ channels in lipid bilayers ("dip-tip" and "Schindler" methodology). Methods in Molecular Biology (Clifton, N.J.). 114: 221-33. PMID 10081021 DOI: 10.1385/1-59259-250-3:221  0.52
1998 Thrower EC, Lea EJ, Dawson AP. The effects of free [Ca2+] on the cytosolic face of the inositol (1,4,5)-trisphosphate receptor at the single channel level. The Biochemical Journal. 330: 559-64. PMID 9461556  0.512
1996 Thrower EC, Duclohier H, Lea EJ, Molle G, Dawson AP. The inositol 1,4,5-trisphosphate-gated Ca2+ channel: effect of the protein thiol reagent thimerosal on channel activity. The Biochemical Journal. 318: 61-6. PMID 8761453  0.408
Low-probability matches (unlikely to be authored by this person)
2005 Thrower E, de Villalvilla AD, Kolodecik T, Gorelick F. EXPLORING MECHANISMS OF ZYMOGEN ACTIVATION WITH A CELL-FREE SYSTEM Pancreas. 31: 474. DOI: 10.1097/01.Mpa.0000193780.34594.E9  0.276
2006 Thrower E, Kolodecik T, Cooma-Ramberan I, Gorelick F. ALCOHOLS ENHANCE VACUOLAR ATPase TRANSLOCATION AND ZYMOGEN ACTIVATION IN CAERULEIN-STIMULATED PANCREATIC ACINAR CELLS Pancreas. 33: 502. DOI: 10.1097/00006676-200611000-00220  0.275
2013 Edderkaoui M, Thrower E. Smoking and Pancreatic Disease. Journal of Cancer Therapy. 4: 34-40. PMID 24660091 DOI: 10.4236/Jct.2013.410A005  0.27
2015 Greer JB, Thrower E, Yadav D. Epidemiologic and Mechanistic Associations Between Smoking and Pancreatitis. Current Treatment Options in Gastroenterology. 13: 332-46. PMID 26109145 DOI: 10.1007/S11938-015-0056-9  0.263
2005 Waterford SD, Kolodecik TR, Thrower EC, Gorelick FS. Vacuolar ATPase regulates zymogen activation in pancreatic acini. The Journal of Biological Chemistry. 280: 5430-4. PMID 15582989 DOI: 10.1074/Jbc.M413513200  0.262
2015 Thrower E. Pathologic cellular events in smoking-related pancreatitis. Cancers. 7: 723-35. PMID 25938854 DOI: 10.3390/Cancers7020723  0.256
2008 Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Current Opinion in Gastroenterology. 24: 580-5. PMID 19122498 DOI: 10.1097/Mog.0B013E32830B10E6  0.256
2008 Gorelick F, Pandol S, Thrower E. Protein kinase C in the pancreatic acinar cell. Journal of Gastroenterology and Hepatology. 23: S37-41. PMID 18336661 DOI: 10.1111/J.1440-1746.2007.05282.X  0.238
2012 Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC. Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G696-704. PMID 22837343 DOI: 10.1152/Ajpgi.00138.2012  0.237
2008 Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR, Pandol SJ, Gorelick FS. The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G1344-53. PMID 18388183 DOI: 10.1152/Ajpgi.00020.2008  0.229
2018 Alahmari AA, Sreekumar B, Patel V, Ashat M, Alexandre M, Uduman AK, Akinbiyi EO, Ceplenski A, Shugrue CA, Kolodecik TR, Tashkandi N, Messenger SW, Groblewski GE, Gorelick FS, Thrower EC. Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice. Plos One. 13: e0197362. PMID 29870540 DOI: 10.1371/Journal.Pone.0197362  0.216
2006 Gorelick FS, Shugrue CA, Kolodecik TR, Thrower EC. Vacuolar adenosine triphosphatase and pancreatic acinar cell function. Journal of Gastroenterology and Hepatology. 21: S18-21. PMID 16958663 DOI: 10.1111/J.1440-1746.2006.04576.X  0.212
2012 Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS. Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Plos One. 7: e41320. PMID 22844459 DOI: 10.1371/Journal.Pone.0041320  0.211
2011 Thrower EC, Yuan J, Usmani A, Liu Y, Jones C, Minervini SN, Alexandre M, Pandol SJ, Guha S. A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G120-9. PMID 20947701 DOI: 10.1152/Ajpgi.00300.2010  0.209
2006 Thrower EC, Diaz de Villalvilla AP, Kolodecik TR, Gorelick FS. Zymogen activation in a reconstituted pancreatic acinar cell system. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G894-902. PMID 16339296 DOI: 10.1152/Ajpgi.00373.2005  0.2
2009 Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS. Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology. 137: 1083-92. PMID 19454288 DOI: 10.1053/J.Gastro.2009.05.041  0.198
2014 Ashat M, Tashkandi N, Sreekumar B, Patel V, Chowdhury AB, Shugrue C, Messenger S, Groblewski GE, Thrower EC. Sa1788 Tobacco Toxin NNK (4-[Methylnitrosamino]-1-[3-Pyridyl]-1-Butanone) Mediates Zymogen Activation in Murine and Human Pancreatic Acini Gastroenterology. 146: S-296. DOI: 10.1016/S0016-5085(14)61058-1  0.193
2009 Kolodecik T, Gorelick F, Thrower E. GENETIC AND PHARMACOLOGIC MANIPULATION OF VACUOLAR ATPASE; EFFECTS ON ZYMOGEN ACTIVATION IN PANCREATIC ACINI. Open Access Animal Physiology. 2009: 1-11. PMID 21572923  0.188
2008 Thrower E, Yuan J, Kelly M, Jones C, Pandol S, Guha S. PROTEIN KINASE D Pancreas. 37: 498. DOI: 10.1097/01.Mpa.0000335400.62423.Be  0.186
2012 Shugrue CA, Alexandre M, Diaz de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC. Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G723-32. PMID 22821946 DOI: 10.1152/Ajpgi.00082.2012  0.184
2014 Thrower E. Print and Digital Media Review Gastroenterology. 146: 1424-1425. DOI: 10.1053/J.Gastro.2014.03.024  0.184
2009 Thrower EC, Yuan J, Jones C, Usmani A, Kelly MK, Ireson C, Pandol SJ, Guha S. S1817 Protein Kinase D Modulates Secretagogue-Induced Zymogen Activation and Amylase Secretion in Rat Pancreatic Acinar Cells Gastroenterology. 136: A-276. DOI: 10.1016/S0016-5085(09)61259-2  0.165
2016 Srinivasan P, Thrower EC, Gorelick FS, Said HM. Inhibition of Pancreatic Acinar Mitochondrial Thiamin Pyrophosphate Uptake by the Cigarette Smoke Component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00461.2015. PMID 26999808 DOI: 10.1152/Ajpgi.00461.2015  0.161
2006 McManaman JL, Reyland ME, Thrower EC. Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. Journal of Mammary Gland Biology and Neoplasia. 11: 249-68. PMID 17136613 DOI: 10.1007/S10911-006-9031-3  0.14
2009 Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR, Gorelick FS, Pandol SJ. Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. Pancreas. 38: 930-5. PMID 19752773 DOI: 10.1097/Mpa.0B013E3181B8476A  0.13
2010 Thrower EC, Gorelick FS, Husain SZ. Molecular and cellular mechanisms of pancreatic injury. Current Opinion in Gastroenterology. 26: 484-9. PMID 20651589 DOI: 10.1097/Mog.0B013E32833D119E  0.126
2015 Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM. Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells. Plos One. 10: e0143575. PMID 26633299 DOI: 10.1371/Journal.Pone.0143575  0.126
2016 Srinivasan P, Thrower EC, Gorelick FS, Said HM. 688 The Cigarette Smoke Component 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) Affects Pancreatic Acinar Mitochondrial Thiamin Pyrophosphate Uptake: Molecular and Cellular Mechanism Gastroenterology. 150: S142. DOI: 10.1016/S0016-5085(16)30579-0  0.121
2011 Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. The emerging role of smoking in the development of pancreatitis. Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]. 11: 469-74. PMID 21986098 DOI: 10.1159/000332196  0.121
2012 Alexandre M, Uduman AK, Shugrue C, Kolodecik T, Akinbiyi E, Gorelick FS, Thrower EC. 83 The Tobacco Toxin NNK Initiates and Sensitizes Acute Pancreatitis Responses In Vivo Gastroenterology. 142: S-20. DOI: 10.1016/S0016-5085(12)60078-X  0.117
2011 Alexandre M, Minervini SN, Patel V, Uduman A, Shugrue C, Gorelick FS, Thrower EC. Tobacco Carcinogen NNK (4-[Methylnitrosamino]-1-[3-Pyridyl]-1-Butanone) Initiates and Sensitizes Acute Pancreatitis Responses Gastroenterology. 140: S-387. DOI: 10.1016/S0016-5085(11)61584-9  0.113
2007 Osgood S, Kolodecik TR, Reeve J, Pandol SJ, Gorelick FS, Thrower EC. DIFFERENTIAL ROLES OF PROTEIN KINASE C ISOFORMS IN ACUTE PANCREATITIS. Pancreas. 35: 420. DOI: 10.1097/01.Mpa.0000297761.67208.E3  0.111
2013 Kolodecik T, Shugrue C, Ashat M, Thrower EC. Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Frontiers in Physiology. 4: 415. PMID 24474939 DOI: 10.3389/fphys.2013.00415  0.099
2015 Zhao X, Zhang Y, Li J, Wan M, Zhu S, Guo H, Xiang J, Thrower EC, Tang W. Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats. Evidence-Based Complementary and Alternative Medicine : Ecam. 2015: 283175. PMID 26199633 DOI: 10.1155/2015/283175  0.085
2010 Atladottir J, Bhoomagoud M, Thrower EC, Shugrue C, Gorelick FS. T1949 Lactate Sensitizes to Pancreatitis Responses in Rats Gastroenterology. 138: S-893. DOI: 10.1016/S0016-5085(10)64126-1  0.078
1965 Jones R, Thrower EN. An analysis of waves in a two-layer composite plate and its application to surface wave propagation experiments on roads Journal of Sound and Vibration. 2: 328-335.  0.016
1961 Thrower EN. Technique for measuring the elastic properties of bitumens, tars and soils under dynamic loading Journal of Scientific Instruments. 38: 69-73. DOI: 10.1088/0950-7671/38/3/301  0.016
1952 Thrower EN. A servo-controlled constant-stress rheometer Journal of Scientific Instruments. 29: 91-93. DOI: 10.1088/0950-7671/29/3/309  0.015
1965 Jones R, Thrower EN. Effect of interfacial contact on the propagation of flexural waves along a composite plate Journal of Sound and Vibration. 2: 167-174.  0.014
1973 Krivissky AM, Kurzeme M, Miura Y, Moavenzadeh F, Elliott JF, Pichumani R, Thrower EN, Lister NW, Potter JF, Ueshita K, Arakawa T, Watanabe Y, Valkering CP, Witczak MW. THIRD INTERNATIONAL CONFERENCE ON THE STRUCTURAL DESIGN OF ASPHALT PAVEMENTS. 0.013
1978 Thrower EN. STRESS INVARIANTS AND MECHANICAL TESTING OF PAVEMENT MATERIALS. Trrl Laboratory Report (Transport and Road Research Laboratory, Great Britain) 0.012
2015 Moore LF, Gray-Garcia TAL, Thrower EH. Black & blue: Policing disability & poverty beyond occupy Occupying Disability: Critical Approaches to Community, Justice, and Decolonizing Disability. 295-318. DOI: 10.1007/978-94-017-9984-3_21  0.01
1979 Thrower EN. PARAMETRIC STUDY OF A FATIGUE PREDICTION MODEL FOR BITUMINOUS ROAD PAVEMENTS. Trrl Laboratory Report (Transport and Road Research Laboratory, Great Britain) 0.01
1975 Thrower EN. DEFORMATION MODEL FOR FLEXIBLE ROAD PAVEMENTS. Trrl Suppl Rep 0.01
1975 Thrower EN. PERMANENT DEFORMATION IN A LINEAR VISCO-ELASTIC MODEL OF A ROAD PAVEMENT. Trrl Suppl Rep 0.01
1967 Thrower EN. An apparatus for measuring the dynamic stiffness of roads and soils Journal of Scientific Instruments. 44: 537-540. DOI: 10.1088/0950-7671/44/7/312  0.01
1965 Thrower EN. The computation of the dispersion of elastic waves in layered media Journal of Sound and Vibration. 2: 210-226.  0.01
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