Dario Renato Alessi, BSc, PhD - Publications

1988-1991 School of Biochemistry University of Birmingham, UK, Birmingham, England, United Kingdom 
 1991- College of Life Science University of Dundee, Dundee, Scotland, United Kingdom 

232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Karayel Ö, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi DR, Steger M, Mann M. Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Molecular & Cellular Proteomics : McP. 19: 1546-1560. PMID 33451735 DOI: 10.1074/mcp.RA120.002055  1
2020 Karayel O, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi D, Steger M, Mann M. Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease. Molecular & Cellular Proteomics : McP. PMID 32601174 DOI: 10.1074/mcp.RA120.002055  1
2020 Fan Y, Tonelli F, Padmanabhan S, Baptista MAS, Riley L, Smith D, Marras C, Howden A, Alessi DR, Sammler E. Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. Journal of Visualized Experiments : Jove. PMID 32250352 DOI: 10.3791/58956  1
2019 Malik N, Nirujogi RS, Peltier J, Macartney T, Wightman M, Prescott AR, Gourlay R, Trost M, Alessi DR, Karapetsas A. Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. The Biochemical Journal. 476: 3081-3107. PMID 31665227 DOI: 10.1042/BCJ20190608  1
2019 Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. Elife. 8. PMID 31663853 DOI: 10.7554/eLife.50416  1
2019 Tovell H, Testa A, Zhou H, Shpiro N, Crafter C, Ciulli A, Alessi DR. Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader. Acs Chemical Biology. PMID 31461270 DOI: 10.1021/acschembio.9b00505  0.36
2019 Tovell H, Testa A, Maniaci C, Zhou H, Prescott AR, Macartney T, Ciulli A, Alessi DR. Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader. Acs Chemical Biology. PMID 30978004 DOI: 10.1021/acschembio.8b01016  1
2018 Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR. A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. Elife. 7. PMID 30398148 DOI: 10.7554/eLife.40202  1
2018 Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, ... ... Alessi DR, et al. Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Acs Chemical Biology. PMID 30102854 DOI: 10.1021/acschembio.7b00638  1
2018 Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, et al. LRRK2 is a negative regulator of phagosome maturation in macrophages. The Embo Journal. PMID 29789389 DOI: 10.15252/embj.201798694  1
2018 Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human. The Biochemical Journal. PMID 29743203 DOI: 10.1042/BCJ20180248  1
2017 Malik N, Macartney T, Hornberger A, Anderson K, Tovell H, Prescott AR, Alessi DR. Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks. The Biochemical Journal. PMID 29150437 DOI: 10.1042/BCJ20170650  1
2017 Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. The Biochemical Journal. PMID 29127256 DOI: 10.1042/BCJ20170802  1
2017 Fan Y, Howden AJ, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. The Biochemical Journal. PMID 29127255 DOI: 10.1042/BCJ20170803  1
2017 Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 6. PMID 29125462 DOI: 10.7554/eLife.31012  1
2017 Gilbert AS, Seoane PI, Sephton-Clark P, Bojarczuk A, Hotham R, Giurisato E, Sarhan AR, Hillen A, Velde GV, Gray NS, Alessi DR, Cunningham DL, Tournier C, Johnston SA, May RC. Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. Science Advances. 3: e1700898. PMID 28835924 DOI: 10.1126/sciadv.1700898  1
2017 Hatcher JM, Choi HG, Alessi DR, Gray NS. Small-Molecule Inhibitors of LRRK2. Advances in Neurobiology. 14: 241-264. PMID 28353288 DOI: 10.1007/978-3-319-49969-7_13  1
2017 Lopez-Guerrero AM, Tomas-Martin P, Pascual-Caro C, Macartney T, Rojas-Fernandez A, Ball G, Alessi DR, Pozo-Guisado E, Martin-Romero FJ. Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains. Scientific Reports. 7: 383. PMID 28341841 DOI: 10.1038/s41598-017-00331-4  1
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Alessi DR, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/srep35986  1
2016 Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, Duddy G, Wilson S, Ho WL, Ho SL, Reith AD, Alessi DR. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. The Biochemical Journal. PMID 27474410 DOI: 10.1042/BCJ20160557  1
2016 Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, ... Alessi DR, et al. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 5. PMID 26824392 DOI: 10.7554/eLife.12813  1
2016 Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MAS, Fiske BK, Fell MJ, Morrow JA, Reith AD, ... Alessi DR, et al. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases Elife. 5. DOI: 10.7554/eLife.12813.001  1
2015 Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, et al. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. Embo Reports. PMID 26116755 DOI: 10.15252/embr.201540352  1
2015 Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 6: 584-9. PMID 26005538 DOI: 10.1021/acsmedchemlett.5b00064  1
2015 Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Human Molecular Genetics. 24: 4545-58. PMID 25994507 DOI: 10.1093/hmg/ddv185  1
2015 Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A. Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry. 58: 3751-6. PMID 25897865 DOI: 10.1021/jm5018779  1
2015 Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR. Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2492-507. PMID 25673844 DOI: 10.1523/JNEUROSCI.4248-14.2015  1
2015 Perez-Oliva AB, Lachaud C, Szyniarowski P, Muñoz I, Macartney T, Hickson I, Rouse J, Alessi DR. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. The Embo Journal. 34: 326-43. PMID 25538220 DOI: 10.15252/embj.201489184  1
2014 Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R, Yang F, Lee CL, ... ... Alessi DR, et al. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nature Medicine. 20: 1340-7. PMID 25326799 DOI: 10.1038/nm.3646  1
2014 Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. The Biochemical Journal. 463: 413-27. PMID 25177796 DOI: 10.1042/BJ20140889  1
2014 Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nature Communications. 5: 4763. PMID 25159004 DOI: 10.1038/ncomms5763  1
2014 Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Science Signaling. 7: re3. PMID 25028718 DOI: 10.1126/scisignal.2005365  1
2014 Banerjee S, Zagórska A, Deak M, Campbell DG, Prescott AR, Alessi DR. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. The Biochemical Journal. 461: 233-45. PMID 24785407 DOI: 10.1042/BJ20140408  1
2014 Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. The Biochemical Journal. 460: 127-39. PMID 24660806 DOI: 10.1042/BJ20140334  1
2014 van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction. The Biochemical Journal. 460: 165-75. PMID 24650431 DOI: 10.1042/BJ20131639  1
2014 Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Open Biology. 4: 130213. PMID 24647965 DOI: 10.1098/rsob.130213  1
2014 Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. The Biochemical Journal. 460: 237-46. PMID 24641320 DOI: 10.1042/BJ20140153  1
2014 de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. The Biochemical Journal. 458: 559-73. PMID 24393035 DOI: 10.1042/BJ20131478  1
2014 Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. The Biochemical Journal. 458: 41-56. PMID 24295069 DOI: 10.1042/BJ20131324  1
2014 Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. The Biochemical Journal. 457: 215-25. PMID 24171924 DOI: 10.1042/BJ20131152  1
2013 Voelkl J, Mia S, Meissner A, Ahmed MS, Feger M, Elvira B, Walker B, Alessi DR, Alesutan I, Lang F. PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction. Kidney & Blood Pressure Research. 38: 156-64. PMID 24685987 DOI: 10.1159/000355763  1
2013 Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry. 70: 758-67. PMID 24239623 DOI: 10.1016/j.ejmech.2013.10.052  1
2013 Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G. N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling. The Journal of Biological Chemistry. 288: 31468-76. PMID 24043619 DOI: 10.1074/jbc.M113.475574  1
2013 Alessi DR, Kulathu Y. Structural biology: Security measures of a master regulator. Nature. 497: 193-4. PMID 23636322 DOI: 10.1038/nature12101  1
2013 Hardie DG, Alessi DR. LKB1 and AMPK and the cancer-metabolism link - ten years after. Bmc Biology. 11: 36. PMID 23587167 DOI: 10.1186/1741-7007-11-36  1
2013 Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR. Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. The Biochemical Journal. 452: 499-508. PMID 23581296 DOI: 10.1042/BJ20130342  1
2013 Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. The Biochemical Journal. 453: 101-13. PMID 23560750 DOI: 10.1042/BJ20121742  1
2013 Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, ... ... Alessi DR, et al. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell. 23: 406-20. PMID 23453624 DOI: 10.1016/j.ccr.2013.01.023  1
2013 Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. The Biochemical Journal. 451: 111-22. PMID 23387299 DOI: 10.1042/BJ20121903  1
2013 Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis. 76: 49-58. PMID 23313773 DOI: 10.1016/j.jpba.2012.12.002  1
2013 Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM. Structural insights into the activation of MST3 by MO25. Biochemical and Biophysical Research Communications. 431: 604-9. PMID 23296203 DOI: 10.1016/j.bbrc.2012.12.113  1
2013 Cohen P, Alessi DR. Kinase drug discovery--what's next in the field? Acs Chemical Biology. 8: 96-104. PMID 23276252 DOI: 10.1021/cb300610s  1
2013 Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics. 22: 328-44. PMID 23065705 DOI: 10.1093/hmg/dds431  1
2012 Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 3: 658-662. PMID 23066449 DOI: 10.1021/ml300123a  1
2012 Najafov A, Shpiro N, Alessi DR. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors. The Biochemical Journal. 448: 285-95. PMID 23030823 DOI: 10.1042/BJ20121287  1
2012 Lewis PA, Alessi DR. Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease. Biochemical Society Transactions. 40: 1039-41. PMID 22988861 DOI: 10.1042/BST20120178  1
2012 Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 60: 981-90. PMID 22949526 DOI: 10.1161/HYPERTENSIONAHA.112.201509  1
2012 Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, Gray NS. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 5625-9. PMID 22863203 DOI: 10.1016/j.bmcl.2012.06.104  1
2012 Landego I, Jayachandran N, Wullschleger S, Zhang TT, Gibson IW, Miller A, Alessi DR, Marshall AJ. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. European Journal of Immunology. 42: 2760-70. PMID 22777911 DOI: 10.1002/eji.201242371  1
2012 Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biology. 2: 120080. PMID 22724072 DOI: 10.1098/rsob.120080  1
2012 Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. Plos One. 7: e39132. PMID 22723946 DOI: 10.1371/journal.pone.0039132  1
2012 Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nature Cell Biology. 14: 686-96. PMID 22609986 DOI: 10.1038/ncb2507  1
2012 Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proceedings of the National Academy of Sciences of the United States of America. 109: 7929-34. PMID 22550170 DOI: 10.1073/pnas.1200947109  1
2012 Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, Alessi DR, Dunlop MG. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 142: 1504-15.e3. PMID 22406476 DOI: 10.1053/j.gastro.2012.02.050  1
2012 Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, Fleming S, Alessi DR, Thompson AM. Phenformin as prophylaxis and therapy in breast cancer xenografts. British Journal of Cancer. 106: 1117-22. PMID 22361631 DOI: 10.1038/bjc.2012.56  1
2012 Zhang J, Deng X, Choi HG, Alessi DR, Gray NS. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 1864-9. PMID 22335897 DOI: 10.1016/j.bmcl.2012.01.084  1
2012 Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. Clinical and Experimental Nephrology. 16: 530-8. PMID 22294159 DOI: 10.1007/s10157-012-0590-x  1
2012 Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, ... ... Alessi DR, et al. Discovery of potent and selective covalent inhibitors of JNK. Chemistry & Biology. 19: 140-54. PMID 22284361 DOI: 10.1016/j.chembiol.2011.11.010  1
2012 Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. The Biochemical Journal. 441: 325-37. PMID 22032326 DOI: 10.1042/BJ20111879  1
2011 Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biology. 1: 110012. PMID 22645651 DOI: 10.1098/rsob.110012  1
2011 Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. The Biochemical Journal. 437: 157-67. PMID 21548880 DOI: 10.1042/BJ20110276  1
2011 Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. Journal of Cell Science. 124: 1391-5. PMID 21486947 DOI: 10.1242/jcs.084111  1
2011 Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy. 7: 696-706. PMID 21460634 DOI: 10.4161/auto.7.7.15451  1
2011 Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. The Embo Journal. 30: 1730-41. PMID 21423148 DOI: 10.1038/emboj.2011.78  1
2011 Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. The Biochemical Journal. 436: 169-79. PMID 21413931 DOI: 10.1042/BJ20102103  1
2011 García-Martínez JM, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi DR, Duce SL. Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice. British Journal of Cancer. 104: 1116-25. PMID 21407213 DOI: 10.1038/bjc.2011.83  1
2011 Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology. 7: 203-5. PMID 21378983 DOI: 10.1038/nchembio.538  1
2011 Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. Journal of Cell Science. 124: 789-800. PMID 21321328 DOI: 10.1242/jcs.077230  1
2011 Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. The Biochemical Journal. 434: 265-74. PMID 21204784 DOI: 10.1042/BJ20102012  1
2011 Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. The Biochemical Journal. 433: 357-69. PMID 21087210 DOI: 10.1042/BJ20101732  1
2011 Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance. Disease Models & Mechanisms. 4: 95-103. PMID 20959631 DOI: 10.1242/dmm.005603  1
2011 Dzamko N, Alessi DR. LRRK2 mutations, regulation and 14-3-3 protein interaction: Implications for Parkinsons disease Future Neurology. 6: 5-8. DOI: 10.2217/fnl.10.77  1
2010 Najafov A, Alessi DR. Uncoupling the Warburg effect from cancer. Proceedings of the National Academy of Sciences of the United States of America. 107: 19135-6. PMID 21041650 DOI: 10.1073/pnas.1014047107  1
2010 Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 5973-82. PMID 20944007 DOI: 10.4049/jimmunol.1000827  1
2010 Pozo-Guisado E, Campbell DG, Deak M, Alvarez-Barrientos A, Morrice NA, Alvarez IS, Alessi DR, Martín-Romero FJ. Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. Journal of Cell Science. 123: 3084-93. PMID 20736304 DOI: 10.1242/jcs.067215  1
2010 Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). The Biochemical Journal. 431: 245-55. PMID 20704563 DOI: 10.1042/BJ20101024  1
2010 Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. The Biochemical Journal. 430: 405-13. PMID 20659021 DOI: 10.1042/BJ20100784  1
2010 Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. The Biochemical Journal. 430: 393-404. PMID 20642453 DOI: 10.1042/BJ20100483  1
2010 Reiche J, Theilig F, Rafiqi FH, Carlo AS, Militz D, Mutig K, Todiras M, Christensen EI, Ellison DH, Bader M, Nykjaer A, Bachmann S, Alessi D, Willnow TE. SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2 Molecular and Cellular Biology. 30: 3027-3037. PMID 20385770 DOI: 10.1128/MCB.01560-09  1
2010 Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Science Signaling. 3: ra25. PMID 20354225 DOI: 10.1126/scisignal.2000616  1
2010 Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. Embo Molecular Medicine. 2: 63-75. PMID 20091762 DOI: 10.1002/emmm.200900058  1
2010 Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. American Journal of Physiology. Endocrinology and Metabolism. 298: E761-9. PMID 20051528 DOI: 10.1152/ajpendo.00421.2009  1
2010 Pearce LR, Komander D, Alessi DR. The nuts and bolts of AGC protein kinases. Nature Reviews. Molecular Cell Biology. 11: 9-22. PMID 20027184 DOI: 10.1038/nrm2822  1
2010 Alessi DR, Van Hook AM. Science signaling podcast: 30 March 2010 Science Signaling. 3: pc7. DOI: 10.1126/scisignal.3115pc7  1
2009 Muqit MM, Alessi DR. A meeting of minds: overcoming roadblocks in the development of therapies for neurodegenerative disorders. Embo Molecular Medicine. 1: 139-41. PMID 20049713 DOI: 10.1002/emmm.200900021  1
2009 Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (New York, N.Y.). 326: 1707-11. PMID 19892943 DOI: 10.1126/science.1178377  1
2009 Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. The Biochemical Journal. 424: 47-60. PMID 19740074 DOI: 10.1042/BJ20091035  1
2009 Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 32: 1620-5. PMID 19564453 DOI: 10.2337/dc08-2175  1
2009 Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. Plos Biology. 7: e1000126. PMID 19513107 DOI: 10.1371/journal.pbio.1000126  1
2009 García-Martínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical Journal. 421: 29-42. PMID 19402821 DOI: 10.1042/BJ20090489  1
2009 Alessi DR, Pearce LR, García-Martínez JM. New insights into mTOR signaling: mTORC2 and beyond. Science Signaling. 2: pe27. PMID 19383978 DOI: 10.1126/scisignal.267pe27  1
2009 San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 4384-9. PMID 19240212 DOI: 10.1073/pnas.0813238106  1
2009 Peifer C, Alessi DR. New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. The Biochemical Journal. 417: e5-7. PMID 19061482 DOI: 10.1042/BJ20082243  1
2009 Boini KM, Amann K, Kempe D, Alessi DR, Lang F. Proteinuria in mice expressing PKB/SGK-resistant GSK3. American Journal of Physiology. Renal Physiology. 296: F153-9. PMID 18987114 DOI: 10.1152/ajprenal.90398.2008  1
2008 Peifer C, Alessi DR. Small-molecule inhibitors of PDK1. Chemmedchem. 3: 1810-38. PMID 18972468 DOI: 10.1002/cmdc.200800195  1
2008 García-Martínez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). The Biochemical Journal. 416: 375-85. PMID 18925875 DOI: 10.1042/BJ20081668  1
2008 Richardson C, Alessi DR. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. Journal of Cell Science. 121: 3293-304. PMID 18843116 DOI: 10.1242/jcs.029223  1
2008 Filippi BM, Alessi DR. Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters. The Journal of Cell Biology. 183: 7-9. PMID 18838550 DOI: 10.1083/jcb.200809056  1
2008 Villa F, Deak M, Alessi DR, van Aalten DM. Structure of the OSR1 kinase, a hypertension drug target. Proteins. 73: 1082-7. PMID 18831043 DOI: 10.1002/prot.22238  1
2008 Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. The Journal of Biological Chemistry. 283: 27653-67. PMID 18669636 DOI: 10.1074/jbc.M802623200  1
2008 Coscia A, Maiorca D, Martano C, Rossi C, Appino I, Cirina P, Alessi D, Fabris C. Use of netilmicin once or twice daily in preterm newborns: Evaluation of nephrotoxicity by urinary α 1-microglobulin and retinol binding protein Journal of Chemotherapy. 20: 324-326. PMID 18606587  1
2008 De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 338-45. PMID 18566399  1
2008 Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC. PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response Cell Metabolism. 7: 291-301. PMID 18396135 DOI: 10.1016/j.cmet.2008.01.006  1
2008 Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. The Biochemical Journal. 412: 211-21. PMID 18387000 DOI: 10.1042/BJ20080557  1
2008 Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, ... ... Alessi DR, et al. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Molecular and Cellular Biology. 28: 3258-72. PMID 18347057 DOI: 10.1128/MCB.02032-07  1
2008 Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. Journal of Cell Science. 121: 675-84. PMID 18270262 DOI: 10.1242/jcs.025312  1
2008 Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. The Biochemical Journal. 411: 249-60. PMID 18254724 DOI: 10.1042/BJ20080067  1
2007 Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. The Biochemical Journal. 408: 297-315. PMID 17850214 DOI: 10.1042/BJ20070797  1
2007 Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM. Structural insights into the recognition of substrates and activators by the OSR1 kinase. Embo Reports. 8: 839-45. PMID 17721439 DOI: 10.1038/sj.embor.7401048  1
2007 Logie L, Ruiz-Alcaraz AJ, Keane M, Woods YL, Bain J, Marquez R, Alessi DR, Sutherland C. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells. Diabetes. 56: 2218-27. PMID 17563061 DOI: 10.2337/db07-0343  1
2007 Pearce LR, Huang X, Boudeau J, Paw?owski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. The Biochemical Journal. 405: 513-22. PMID 17461779 DOI: 10.1042/BJ20070540  1
2007 Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. The Biochemical Journal. 405: 307-17. PMID 17447891 DOI: 10.1042/BJ20070209  1
2007 Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. The Journal of Cell Biology. 176: 89-100. PMID 17190791 DOI: 10.1083/jcb.200605093  1
2007 Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. The Biochemical Journal. 401: 29-38. PMID 17040210 DOI: 10.1042/BJ20061088  1
2007 Alessi DR, Zeqiraj E. Protein phosphorylation: The governor Biochemist. 29: 20-23.  1
2006 Rexhepaj R, Grahammer F, Völkl H, Remy C, Wagner CA, Sandulache D, Artunc F, Henke G, Nammi S, Capasso G, Alessi DR, Lang F. Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2214-22. PMID 17077298 DOI: 10.1096/fj.05-5676com  1
2006 Budas GR, Sukhodub A, Alessi DR, Jovanović A. 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2556-8. PMID 17077284 DOI: 10.1096/fj.06-6252fje  1
2006 Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR. Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. Journal of Cell Science. 119: 4059-70. PMID 16968750 DOI: 10.1242/jcs.03097  1
2006 Bayascas JR, Sakamoto K, Armit L, Arthur JS, Alessi DR. Evaluation of approaches to generation of tissue-specific knock-in mice. The Journal of Biological Chemistry. 281: 28772-81. PMID 16887794 DOI: 10.1074/jbc.M606789200  1
2006 Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR. Emerging roles of pseudokinases. Trends in Cell Biology. 16: 443-52. PMID 16879967 DOI: 10.1016/j.tcb.2006.07.003  1
2006 Sandu C, Artunc F, Palmada M, Rexhepaj R, Grahammer F, Hussain A, Yun C, Alessi DR, Lang F. Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse. American Journal of Physiology. Gastrointestinal and Liver Physiology. 291: G868-76. PMID 16825708 DOI: 10.1152/ajpgi.00023.2006  1
2006 Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent signaling pathways Annual Review of Biochemistry. 75: 137-163. PMID 16756488 DOI: 10.1146/annurev.biochem.75.103004.142702  1
2006 Artunc F, Rexhepaj R, Völkl H, Grahammer F, Remy C, Sandulache D, Nasir O, Wagner CA, Alessi DR, Lang F. Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291: R1533-R1538. PMID 16741145 DOI: 10.1152/ajpregu.00024.2006  1
2006 Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HKR, Alessi DR. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 Biochemical Journal. 397: 223-231. PMID 16669787 DOI: 10.1042/BJ20060220  1
2006 Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DMF, Alessi DR. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation Biochemical Journal. 394: 545-555. PMID 16396636 DOI: 10.1042/BJ20051844  1
2006 Sakamoto K, Zarrinpashneh E, Budas GR, Pouleur AC, Dutta A, Prescott AR, Vanoverschelde JL, Ashworth A, Jovanović A, Alessi DR, Bertrand L. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. American Journal of Physiology. Endocrinology and Metabolism. 290: E780-8. PMID 16332922 DOI: 10.1152/ajpendo.00443.2005  1
2005 Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK Journal of Cell Science. 118: 5661-5673. PMID 16306228 DOI: 10.1242/jcs.02670  1
2005 Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Current Biology : Cb. 15: 1839-46. PMID 16243031 DOI: 10.1016/j.cub.2005.08.066  1
2005 Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR. In vivo role of the phosphate groove of PDK1 defined by knockin mutation. Journal of Cell Science. 118: 5023-34. PMID 16219676 DOI: 10.1242/jcs.02617  1
2005 Lipina C, Huang X, Finlay D, McManus EJ, Alessi DR, Sutherland C. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3 Biochemical Journal. 392: 633-639. PMID 16176184 DOI: 10.1042/BJ20051046  1
2005 Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases Biochemical Journal. 391: 17-24. PMID 16083423 DOI: 10.1042/BJ20051180  1
2005 Mora A, Sakamoto K, McManus EJ, Alessi DR. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart Febs Letters. 579: 3632-3638. PMID 15961082 DOI: 10.1016/j.febslet.2005.05.040  1
2005 Sakamoto K, McCarthy A, Smith D, Green KA, Hardie DG, Ashworth A, Alessi DR. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction Embo Journal. 24: 1810-1820. PMID 15889149 DOI: 10.1038/sj.emboj.7600667  1
2005 Evans JMM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients British Medical Journal. 330: 1304-1305. PMID 15849206 DOI: 10.1136/bmj.38415.708634.F7  1
2005 Bayascas JR, Alessi DR. Regulation of Akt/PKB Ser473 phosphorylation Molecular Cell. 18: 143-145. PMID 15837416 DOI: 10.1016/j.molcel.2005.03.020  1
2005 McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, Alessi DR. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. The Embo Journal. 24: 1571-83. PMID 15791206 DOI: 10.1038/sj.emboj.7600633  1
2005 Komander D, Kular G, Deak M, Alessi DR, Van Aalten DMF. Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding Journal of Biological Chemistry. 280: 18797-18802. PMID 15741170 DOI: 10.1074/jbc.M500977200  1
2005 Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate Febs Letters. 579: 1417-1423. PMID 15733851 DOI: 10.1016/j.febslet.2005.01.042  1
2005 Dümmler BA, Hauge C, Silber J, Yntema HG, Kruse LS, Kofoed B, Hemmings BA, Alessi DR, Frödin M. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types Journal of Biological Chemistry. 280: 13304-13314. PMID 15632195 DOI: 10.1074/jbc.M408194200  1
2005 Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure Biochemical Journal. 385: 639-648. PMID 15554902 DOI: 10.1042/BJ20041782  1
2004 Schutkowski M, Reimer U, Panse S, Dong L, Lizcano JM, Alessi DR, Schneider-Mergener J. High-content peptide microarrays for deciphering kinase specificity and biology. Angewandte Chemie (International Ed. in English). 43: 2671-4. PMID 18629986 DOI: 10.1002/anie.200453900  1
2004 Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Analysis of the LKB1-STRAD-MO25 complex. Journal of Cell Science. 117: 6365-75. PMID 15561763 DOI: 10.1242/jcs.01571  1
2004 Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Downes CP, Safrany ST, Alessi DR, Van Aalten DMF. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates Embo Journal. 23: 3918-3928. PMID 15457207 DOI: 10.1038/sj.emboj.7600379  1
2004 McManus EJ, Alessi DR. Cancer, oncogenes and signal transdution Genome Biology. 5. PMID 15239827 DOI: 10.1186/gb-2004-5-7-332  1
2004 Mora A, Komander D, Van Aalten DMF, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction Seminars in Cell and Developmental Biology. 15: 161-170. PMID 15209375 DOI: 10.1016/j.semcdb.2003.12.022  1
2004 McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. The Embo Journal. 23: 2071-82. PMID 15116068 DOI: 10.1038/sj.emboj.7600218  1
2004 Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA. FAPPS control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P Nature Cell Biology. 6: 393-404. PMID 15107860 DOI: 10.1038/ncb1119  1
2004 Hinton HJ, Alessi DR, Cantrell DA. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development Nature Immunology. 5: 539-545. PMID 15077109 DOI: 10.1038/ni1062  1
2004 Sakamoto K, Göransson O, Hardie DG, Alessi DR. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR American Journal of Physiology - Endocrinology and Metabolism. 287: E310-E317. PMID 15068958 DOI: 10.1152/ajpendo.00074.2004  1
2004 Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 Embo Journal. 23: 833-843. PMID 14976552 DOI: 10.1038/sj.emboj.7600110  1
2004 Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KRC, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, Van Aalten DMF. Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1 Structure. 12: 215-226. PMID 14962382 DOI: 10.1016/S0969-2126(04)00007-3  1
2004 Milburn CC, Boudeau J, Deak M, Alessi DR, Van Aalten DMF. Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor Nature Structural and Molecular Biology. 11: 193-200. PMID 14730349 DOI: 10.1038/nsmb716  1
2004 Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate Biochemical Journal. 378: 257-268. PMID 14611643 DOI: 10.1042/BJ20031692  1
2003 Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. The Embo Journal. 22: 5102-14. PMID 14517248 DOI: 10.1093/emboj/cdg490  1
2003 Kimber WA, Deak M, Prescott AR, Alessi DR. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1 Biochemical Journal. 376: 525-535. PMID 14516276 DOI: 10.1042/BJ20031154  1
2003 Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of Biology. 2: 28. PMID 14511394 DOI: 10.1186/1475-4924-2-28  1
2003 Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, Mouton V, Kahn CR, Lucocq JM, Gray GA, Jovanović A, Alessi DR. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia Embo Journal. 22: 4666-4676. PMID 12970179 DOI: 10.1093/emboj/cdg469  1
2003 Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. The Biochemical Journal. 375: 531-8. PMID 12964941 DOI: 10.1042/BJ20031229  1
2003 Collins BJ, Deak M, Arthur JSC, Armit LJ, Alessi DR. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation Embo Journal. 22: 4202-4211. PMID 12912918 DOI: 10.1093/emboj/cdg407  1
2003 Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DMF. Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition Biochemical Journal. 375: 255-262. PMID 12892559 DOI: 10.1042/BJ20031119  1
2003 Lizcano JM, Alrubaie S, Kieloch A, Deak M, Leevers SJ, Alessi DR. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B Biochemical Journal. 374: 297-306. PMID 12841848 DOI: 10.1042/BJ20030577  1
2003 Boudeau J, Sapkota G, Alessi DR. LKB1, a protein kinase regulating cell proliferation and polarity Febs Letters. 546: 159-165. PMID 12829253 DOI: 10.1016/S0014-5793(03)00642-2  1
2003 Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Embo Journal. 22: 3062-3072. PMID 12805220 DOI: 10.1093/emboj/cdg292  1
2003 Boudeau J, Kieloch A, Alessi DR, Stella A, Guanti G, Resta N. Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients Human Mutation. 21: 172. PMID 12552571  1
2003 Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation Journal of Biological Chemistry. 278: 8199-8211. PMID 12510059 DOI: 10.1074/jbc.M209153200  1
2003 Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. The Biochemical Journal. 370: 849-57. PMID 12489981 DOI: 10.1042/BJ20021813  1
2003 Alessi DR. Role of PDK1 in Activating AGC Protein Kinase Handbook of Cell Signaling. 2: 193-202. DOI: 10.1016/B978-012124546-7/50515-5  1
2003 Alessi DR. Role of PDK1 in Acutivating AGC Protein Kinase Handbook of Cell Signaling. 1: 513-522. DOI: 10.1016/B978-012124546-7/50447-2  1
2002 Hamm J, Alessi DR, Biondi RM. Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase Journal of Biological Chemistry. 277: 45793-45802. PMID 12235136 DOI: 10.1074/jbc.M205072200  1
2002 Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical Journal. 368: 507-16. PMID 12234250 DOI: 10.1042/BJ20021284  1
2002 McManus EJ, Alessi DR. TSC1-TSC2: A complex tale of PKB-mediated S6K regulation Nature Cell Biology. 4: E214-E216. PMID 12205484 DOI: 10.1038/ncb0902-e214  1
2002 Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. The Biochemical Journal. 368: 243-51. PMID 12186630 DOI: 10.1042/BJ20020973  1
2002 Thomas CC, Deak M, Alessi DR, Van Aalten DMF. High-resolution structure of the pleckstrin homology domain of protein kinase B/Akt bound to phosphatidylinositol (3,4,5)-trisphosphate Current Biology. 12: 1256-1262. PMID 12176338 DOI: 10.1016/S0960-9822(02)00972-7  1
2002 Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, Van Aalten DMF. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site Embo Journal. 21: 4219-4228. PMID 12169624 DOI: 10.1093/emboj/cdf437  1
2002 Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, Polakiewicz RD, Comb MJ. Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. The Journal of Biological Chemistry. 277: 39379-87. PMID 12151408 DOI: 10.1074/jbc.M206399200  1
2002 Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. Essential role of PDK1 in regulating cell size and development in mice. The Embo Journal. 21: 3728-38. PMID 12110585 DOI: 10.1093/emboj/cdf387  1
2002 Lizcano JM, Deak M, Morrice N, Kieloch A, James Hastie C, Dong L, Schutkowski M, Reimer U, Alessi DR. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo Journal of Biological Chemistry. 277: 27839-27849. PMID 12023960 DOI: 10.1074/jbc.M202042200  1
2002 Dowler S, Kular G, Alessi DR. Protein lipid overlay assay Science's Stke : Signal Transduction Knowledge Environment. 2002: PL6. PMID 11972359  1
2002 Lizcano JM, Alessi DR. The insulin signalling pathway Current Biology. 12: R236. PMID 11937037 DOI: 10.1016/S0960-9822(02)00777-7  1
2002 Sapkota GP, Boubeau J, Deak M, Kieloch A, Morrice N, Alessi DR. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr366 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome Biochemical Journal. 362: 481-490. PMID 11853558 DOI: 10.1042/0264-6021:3620481  1
2002 Kimber WA, Trinkle-Mulcahy L, Cheung PCF, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo Biochemical Journal. 361: 525-536. PMID 11802782 DOI: 10.1042/0264-6021:3610525  1
2001 Leslie NR, Biondi RM, Alessi DR. Phosphoinositide-regulated kinases and phosphoinositide phosphatases Chemical Reviews. 101: 2365-2380. PMID 11749378 DOI: 10.1021/cr000091i  1
2001 Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? Journal of Cell Science. 114: 2903-10. PMID 11686294  1
2001 Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Molecular Cell. 8: 693-704. PMID 11583630 DOI: 10.1016/S1097-2765(01)00324-0  1
2001 Thomas CC, Dowler S, Deak M, Alessi DR, Van Aalten DMF. Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): Molecular basis of lipid specificity Biochemical Journal. 358: 287-294. PMID 11513726 DOI: 10.1042/0264-6021:3580287  1
2001 Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB Embo Journal. 20: 4380-4390. PMID 11500365 DOI: 10.1093/emboj/20.16.4380  1
2001 Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase Embo Journal. 20: 4370-4379. PMID 11500364 DOI: 10.1093/emboj/20.16.4370  1
2001 Mora A, Sabio G, González-Polo RA, Cuenda A, Alessi DR, Alonso JC, Fuentes JM, Soler G, Centeno F. Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells Journal of Neurochemistry. 78: 199-206. PMID 11432986 DOI: 10.1046/j.1471-4159.2001.00410.x  1
2001 Alessi DR. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture Biochemical Society Transactions. 29: 1-14. PMID 11356119  1
2001 Zhang MY, Barber DL, Alessi DR, Bell LL, Stine C, Nguyen MH, Beattie BK, Cheung JY, Miller BA. A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation. Experimental Hematology. 29: 432-40. PMID 11301183 DOI: 10.1016/S0301-472X(00)00681-0  1
2001 Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. The Journal of Biological Chemistry. 276: 19469-82. PMID 11297520 DOI: 10.1074/jbc.M009953200  1
2001 Alessi DR. Discovery of PDKI, one of the missing links in insulin signal transduction Biochemical Society Transactions. 29: 1-14. DOI: 10.1042/0300-5127:0290001  1
2000 Balendran A, Hare GR, Kieloch A, Williams MR, Alessi DR. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms Febs Letters. 484: 217-223. PMID 11078882 DOI: 10.1016/S0014-5793(00)02162-1  1
2000 Grillo S, Grémeaux T, Casamayor A, Alessi DR, Marchand-Brustel YL, Tanti JF. Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1. Potential involvement of Src kinase European Journal of Biochemistry. 267: 6642-6649. PMID 11054117 DOI: 10.1046/j.1432-1327.2000.01759.x  1
2000 Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities Biochemical Journal. 351: 19-31. PMID 11001876 DOI: 10.1042/0264-6021:3510019  1
2000 Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R, Unterman TG. Regulation of glucose-6-phosphatase gene expression by protein kinase Bα and the Forkhead transcription factor FKHR: Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity Journal of Biological Chemistry. 275: 36324-36333. PMID 10960473 DOI: 10.1074/jbc.M003616200  1
2000 Cuenda A, Alessi DR. Use of kinase inhibitors to dissect signaling pathways Methods in Molecular Biology (Clifton, N.J.). 99: 161-175. PMID 10909084  1
2000 Dowler S, Montalvo L, Cantrell D, Morrice N, Alessi DR. Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase Biochemical Journal. 349: 605-610. PMID 10880360 DOI: 10.1042/0264-6021:3490605  1
2000 Williams MR, Arthur JSC, Balendran A, Van der Kaay J, Poli V, Cohen P, Alessi DR. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells Current Biology. 10: 439-448. PMID 10801415 DOI: 10.1016/S0960-9822(00)00441-3  1
2000 Balendran A, Biondi RM, Cheung PCF, Casamayor A, Deak M, Alessi DR. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC- related kinase 2 by PDK1 Journal of Biological Chemistry. 275: 20806-20813. PMID 10764742 DOI: 10.1074/jbc.M000421200  1
2000 Deprez J, Bertrand L, Alessi DR, Krause U, Hue L, Rider MH. Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase Biochemical Journal. 347: 305-312. PMID 10727432 DOI: 10.1042/0264-6021:3470305  1
2000 Biondi RM, Cheung PCF, Casamayor A, Deak M, Currie RA, Alessi DR. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA Embo Journal. 19: 979-988. PMID 10698939  1
2000 Vanhaesebroeck B, Alessi DR. The PI3K-PBK1 connection: More than just a road to PKB Biochemical Journal. 346: 561-576. PMID 10698680 DOI: 10.1042/0264-6021:3460561  1
2000 Ryder JW, Fahlman R, Wallberg-Henrikssont H, Alessi DR, Krookt A, Zierath JR. Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement of the mitogen- and stress- activated protein kinase Journal of Biological Chemistry. 275: 1457-1462. PMID 10625698 DOI: 10.1074/jbc.275.2.1457  1
1999 Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252 Journal of Biological Chemistry. 274: 37400-37406. PMID 10601311 DOI: 10.1074/jbc.274.52.37400  1
1999 Navé BT, Ouwens DM, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation Biochemical Journal. 344: 427-431. PMID 10567225 DOI: 10.1042/0264-6021:3440427  1
1999 Bertrand L, Alessi DR, Deprez J, Deak M, Viaene E, Rider MH, Hue L. Heart 6-phosphofructo-2-kinase activation by insulin results from Ser- 466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B Journal of Biological Chemistry. 274: 30927-30933. PMID 10521487 DOI: 10.1074/jbc.274.43.30927  1
1999 Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo Biochemical Journal. 342: 287-292. PMID 10455013 DOI: 10.1042/0264-6021:3420287  1
1999 Dowler S, Currie RA, Downes CP, Alessi DR. DAPP1: A dual adaptor for phosphotyrosine and 3-phosphoinositides Biochemical Journal. 342: 7-12. PMID 10432293 DOI: 10.1042/0264-6021:3420007  1
1999 Deak M, Casamayor A, Currie RA, Peter Downes C, Alessi DR. Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain Febs Letters. 451: 220-226. PMID 10371193 DOI: 10.1016/S0014-5793(99)00556-6  1
1999 Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 Current Biology. 9: 393-404. PMID 10226025 DOI: 10.1016/S0960-9822(99)80186-9  1
1999 Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Current Biology : Cb. 9: 186-97. PMID 10074427 DOI: 10.1016/S0960-9822(99)80088-8  1
1999 Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Biochemical Journal. 337: 575-583. PMID 9895304 DOI: 10.1042/0264-6021:3370575  1
1998 Deak M, Clifton AD, Lucocq LM, Alessi DR. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. The Embo Journal. 17: 4426-41. PMID 9687510 DOI: 10.1093/emboj/17.15.4426  1
1998 Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide dependent protein kinase-1 in vitro: Comparison with protein kinase B α Biochemical Journal. 331: 299-308. PMID 9512493 DOI: 10.1042/bj3310299  1
1997 Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Current Biology : Cb. 7: 776-89. PMID 9368760  1
1997 Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades Journal of Biological Chemistry. 272: 17269-17275. PMID 9211863 DOI: 10.1074/jbc.272.28.17269  1
1997 Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Current Biology : Cb. 7: 261-9. PMID 9094314  1
1996 James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, Alessi DR. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. The Biochemical Journal. 315: 709-13. PMID 8645147  1
1995 Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo Journal of Biological Chemistry. 270: 27489-27494. PMID 7499206 DOI: 10.1074/jbc.270.46.27489  1
1992 Alessi DR, Corrie JE, Fajer PG, Ferenczi MA, Thomas DD, Trayer IP, Trentham DR. Synthesis and properties of a conformationally restricted spin-labeled analog of ATP and its interaction with myosin and skeletal muscle. Biochemistry. 31: 8043-54. PMID 1324724  1
1991 Alessi DR, Corrie JET, Feeney J, Trayer IP, Trentham DR. Conformationally restricted spin labelled nucleotides: A model study of the synthesis and properties of the 2′,3′-O-spiro ketal of uridine and 4-oxo-2,2,6,6-tetramethyl-1-piperidyloxy Journal of the Chemical Society, Perkin Transactions 1. 2243-2247.  1
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