| Year |
Citation |
Score |
| 2023 |
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J. Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.). 382: 1404-1411. PMID 38127736 DOI: 10.1126/science.adi9926 |
0.513 |
|
| 2023 |
Pal P, Taylor M, Lam PY, Tonelli F, Hecht CA, Lis P, Nirujogi RS, Phung TK, Yeshaw WM, Jaimon E, Fasimoye R, Dickie EA, Wightman M, Macartney T, Pfeffer SR, ... Alessi DR, et al. Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B. Science Advances. 9: eadj1205. PMID 38091401 DOI: 10.1126/sciadv.adj1205 |
0.397 |
|
| 2023 |
Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR. Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. Elife. 12. PMID 37874635 DOI: 10.7554/eLife.87098 |
0.535 |
|
| 2023 |
Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, ... ... Alessi DR, et al. High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma. Cell Reports. Medicine. 101244. PMID 37858338 DOI: 10.1016/j.xcrm.2023.101244 |
0.334 |
|
| 2023 |
Hatcher JM, Zwirek M, Sarhan AR, Vatsan PS, Tonelli F, Alessi DR, Davies P, Gray NS. Development of a Highly Potent and Selective Degrader of LRRK2. Bioorganic & Medicinal Chemistry Letters. 129449. PMID 37591317 DOI: 10.1016/j.bmcl.2023.129449 |
0.611 |
|
| 2023 |
Borsche M, Pratuseviciute N, Schaake S, Hinrichs F, Morel G, Uter J, Lohmann K, Klein C, Alessi DR, Hagenah J, Sammler E. The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 36971062 DOI: 10.1002/mds.29385 |
0.387 |
|
| 2023 |
Newton AC, Alessi DR. Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. Iubmb Life. 75: 282-283. PMID 36905647 DOI: 10.1002/iub.2715 |
0.315 |
|
| 2022 |
Vides EG, Adhikari A, Chiang CY, Lis P, Purlyte E, Limouse C, Shumate JL, Spinola-Lasso E, Dhekne HS, Alessi DR, Pfeffer SR. A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. Elife. 11. PMID 36149401 DOI: 10.7554/eLife.79771 |
0.541 |
|
| 2022 |
Malik AU, Karapetsas A, Nirujogi RS, Chatterjee D, Phung TK, Wightman M, Gourlay R, Morrice N, Mathea S, Knapp S, Alessi DR. PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. The Biochemical Journal. 479: 1941-1965. PMID 36040231 DOI: 10.1042/BCJ20220308 |
0.581 |
|
| 2022 |
Liu X, Kalogeropulou AF, Domingos S, Makukhin N, Nirujogi RS, Singh F, Shpiro N, Saalfrank A, Sammler E, Ganley IG, Moreira R, Alessi DR, Ciulli A. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society. PMID 36007011 DOI: 10.1021/jacs.2c05499 |
0.383 |
|
| 2022 |
Kalogeropulou AF, Purlyte E, Tonelli F, Lange SM, Wightman M, Prescott AR, Padmanabhan S, Sammler E, Alessi DR. Impact of 100 LRRK2 variants linked to Parkinson's Disease on kinase activity and microtubule binding. The Biochemical Journal. PMID 35950872 DOI: 10.1042/BCJ20220161 |
0.523 |
|
| 2022 |
Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning C, Sorrell FJ, D'Angiolella V, Fischer R, Mulder M, Gamba G, Alessi DR, Bullock AN. Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. The Biochemical Journal. PMID 35179207 DOI: 10.1042/BCJ20220019 |
0.544 |
|
| 2021 |
Khan SS, Sobu Y, Dhekne HS, Tonelli F, Berndsen K, Alessi DR, Pfeffer SR. Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. Elife. 10. PMID 34658337 DOI: 10.7554/eLife.67900 |
0.382 |
|
| 2021 |
Waschbüsch D, Berndsen K, Lis P, Knebel A, Lam YP, Alessi DR, Khan AR. Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. Embo Reports. e52675. PMID 34580980 DOI: 10.15252/embr.202152675 |
0.418 |
|
| 2021 |
Tasegian A, Singh F, Ganley IG, Reith AD, Alessi DR. Impact of Type II LRRK2 inhibitors on signalling and mitophagy. The Biochemical Journal. PMID 34515301 DOI: 10.1042/BCJ20210375 |
0.417 |
|
| 2021 |
Fan Y, Nirujogi RS, Garrido A, Ruiz-Martínez J, Bergareche-Yarza A, Mondragón-Rezola E, Vinagre-Aragón A, Croitoru I, Gorostidi Pagola A, Paternain Markinez L, Alcalay R, Hickman RA, Düring J, Gomes S, Pratuseviciute N, ... ... Alessi DR, et al. R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils. Acta Neuropathologica. PMID 34125248 DOI: 10.1007/s00401-021-02325-z |
0.533 |
|
| 2021 |
Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukova O, Argaiz ER, Lerdo de Tejada F, Murillo-de-Ozores AR, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castaneda-Bueno M, Alessi DR, Gamba G. Role of KLHL3 and dietary K in regulating KS-WNK1 expression. American Journal of Physiology. Renal Physiology. PMID 33682442 DOI: 10.1152/ajprenal.00575.2020 |
0.564 |
|
| 2021 |
Malik AU, Karapetsas A, Nirujogi RS, Mathea S, Chatterjee D, Pal P, Lis P, Taylor M, Purlyte E, Gourlay R, Dorward M, Weidlich S, Toth R, Polinski NK, Knapp S, ... ... Alessi DR, et al. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. The Biochemical Journal. PMID 33459343 DOI: 10.1042/BCJ20200937 |
0.574 |
|
| 2020 |
Nirujogi RS, Tonelli F, Taylor M, Lis P, Zimprich A, Sammler E, Alessi DR. Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites. The Biochemical Journal. PMID 33367571 DOI: 10.1042/BCJ20200930 |
0.502 |
|
| 2020 |
Kalogeropulou AF, Freemantle JB, Lis P, Vides EG, Polinski NK, Alessi DR. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. The Biochemical Journal. PMID 33135724 DOI: 10.1042/BCJ20200458 |
0.517 |
|
| 2020 |
Karayel O, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi D, Steger M, Mann M. Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease. Molecular & Cellular Proteomics : McP. PMID 32601174 DOI: 10.1074/Mcp.Ra120.002055 |
0.414 |
|
| 2020 |
Fan Y, Tonelli F, Padmanabhan S, Baptista MAS, Riley L, Smith D, Marras C, Howden A, Alessi DR, Sammler E. Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. Journal of Visualized Experiments : Jove. PMID 32250352 DOI: 10.3791/58956 |
0.489 |
|
| 2020 |
Taylor M, Alessi DR. Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease. Current Opinion in Cell Biology. 63: 102-113. PMID 32036294 DOI: 10.1016/J.Ceb.2020.01.001 |
0.423 |
|
| 2020 |
Waschbüsch D, Purlyte E, Pal P, McGrath E, Alessi DR, Khan AR. Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. Structure (London, England : 1993). PMID 32017888 DOI: 10.1016/J.Str.2020.01.005 |
0.415 |
|
| 2019 |
Malik N, Nirujogi RS, Peltier J, Macartney T, Wightman M, Prescott AR, Gourlay R, Trost M, Alessi DR, Karapetsas A. Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. The Biochemical Journal. 476: 3081-3107. PMID 31665227 DOI: 10.1042/Bcj20190608 |
0.574 |
|
| 2019 |
Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. Elife. 8. PMID 31663853 DOI: 10.7554/Elife.50416 |
0.503 |
|
| 2019 |
Gomez RC, Wawro P, Lis P, Alessi DR, Pfeffer SR. Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. The Journal of Cell Biology. PMID 31624137 DOI: 10.1083/Jcb.201902184 |
0.382 |
|
| 2019 |
Tovell H, Testa A, Zhou H, Shpiro N, Crafter C, Ciulli A, Alessi DR. Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader. Acs Chemical Biology. PMID 31461270 DOI: 10.1021/Acschembio.9B00505 |
0.494 |
|
| 2019 |
Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. The Embo Journal. 38. PMID 30647193 DOI: 10.15252/embj.2018101237 |
0.407 |
|
| 2019 |
Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. Crystal structure of the WD40 domain dimer of LRRK2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30635421 DOI: 10.2210/Pdb6Dlo/Pdb |
0.459 |
|
| 2018 |
Osborne J, Birchall K, Tsagris DJ, Lewis SJ, Smiljanic-Hurley E, Taylor DL, Levy A, Alessi DR, McIver EG. Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1. Bioorganic & Medicinal Chemistry Letters. PMID 30554956 DOI: 10.1016/J.Bmcl.2018.11.058 |
0.373 |
|
| 2018 |
Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR. A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. Elife. 7. PMID 30398148 DOI: 10.7554/Elife.40202 |
0.468 |
|
| 2018 |
Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N. Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. Neurobiology of Disease. PMID 30194047 DOI: 10.1016/J.Nbd.2018.09.003 |
0.301 |
|
| 2018 |
Vagnarelli P, Alessi DR. PP1 Phosphatase Complexes: Undruggable No Longer. Cell. 174: 1049-1051. PMID 30142342 DOI: 10.1016/J.Cell.2018.08.007 |
0.458 |
|
| 2018 |
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, ... ... Alessi DR, et al. Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Acs Chemical Biology. PMID 30102854 DOI: 10.2210/Pdb6Cd5/Pdb |
0.731 |
|
| 2018 |
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT. LRRK2 activation in idiopathic Parkinson's disease. Science Translational Medicine. 10. PMID 30045977 DOI: 10.1126/Scitranslmed.Aar5429 |
0.454 |
|
| 2018 |
Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, et al. LRRK2 is a negative regulator of phagosome maturation in macrophages. The Embo Journal. PMID 29789389 DOI: 10.15252/Embj.201798694 |
0.501 |
|
| 2018 |
Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human. The Biochemical Journal. PMID 29743203 DOI: 10.1042/Bcj20180248 |
0.415 |
|
| 2018 |
Alessi DR, Sammler E. LRRK2 kinase in Parkinson's disease. Science (New York, N.Y.). 360: 36-37. PMID 29622645 DOI: 10.1126/Science.Aar5683 |
0.371 |
|
| 2017 |
Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. The Embo Journal. PMID 29212815 DOI: 10.15252/Embj.201798099 |
0.567 |
|
| 2017 |
Malik N, Macartney T, Hornberger A, Anderson K, Tovell H, Prescott AR, Alessi DR. Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks. The Biochemical Journal. PMID 29150437 DOI: 10.1042/Bcj20170650 |
0.406 |
|
| 2017 |
Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. The Biochemical Journal. PMID 29127256 DOI: 10.1042/Bcj20170802 |
0.445 |
|
| 2017 |
Fan Y, Howden AJ, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. The Biochemical Journal. PMID 29127255 DOI: 10.1042/Bcj20170803 |
0.526 |
|
| 2017 |
Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. Elife. 6. PMID 29125462 DOI: 10.7554/Elife.31012 |
0.435 |
|
| 2017 |
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/Nature24006 |
0.303 |
|
| 2017 |
Cervantes-Perez LG, Castaneda-Bueno M, Jimenez JV, Vazquez N, Rojas-Vega L, Alessi DR, Bobadilla NA, Gamba G. Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II. Journal of Hypertension. PMID 28877076 DOI: 10.1097/Hjh.0000000000001554 |
0.436 |
|
| 2017 |
Gilbert AS, Seoane PI, Sephton-Clark P, Bojarczuk A, Hotham R, Giurisato E, Sarhan AR, Hillen A, Velde GV, Gray NS, Alessi DR, Cunningham DL, Tournier C, Johnston SA, May RC. Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. Science Advances. 3: e1700898. PMID 28835924 DOI: 10.1126/Sciadv.1700898 |
0.546 |
|
| 2017 |
Hatcher JM, Choi HG, Alessi DR, Gray NS. Small-Molecule Inhibitors of LRRK2. Advances in Neurobiology. 14: 241-264. PMID 28353288 DOI: 10.1007/978-3-319-49969-7_13 |
0.598 |
|
| 2016 |
Jayachandran N, Landego I, Hou S, Alessi DR, Marshall AJ. B cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. European Journal of Immunology. PMID 27859053 DOI: 10.1002/Eji.201646596 |
0.312 |
|
| 2016 |
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Alessi DR, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/Srep35986 |
0.733 |
|
| 2016 |
Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR. The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. The Embo Journal. PMID 27481935 DOI: 10.15252/Embj.201693929 |
0.463 |
|
| 2016 |
Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, Duddy G, Wilson S, Ho WL, Ho SL, Reith AD, Alessi DR. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. The Biochemical Journal. PMID 27474410 DOI: 10.1042/Bcj20160557 |
0.59 |
|
| 2016 |
Castel P, Ellis H, Bago R, Toska E, Razavi P, Carmona FJ, Kannan S, Verma CS, Dickler M, Chandarlapaty S, Brogi E, Alessi DR, Baselga J, Scaltriti M. PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition. Cancer Cell. PMID 27451907 DOI: 10.1016/J.Ccell.2016.06.004 |
0.331 |
|
| 2016 |
Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, ... Alessi DR, et al. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 5. PMID 26824392 DOI: 10.7554/Elife.12813 |
0.517 |
|
| 2015 |
Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, et al. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. Embo Reports. PMID 26116755 DOI: 10.15252/Embr.201540352 |
0.665 |
|
| 2015 |
Horbert R, Pinchuk B, Davies P, Alessi D, Peifer C. Photoactivatable prodrugs of anti-melanoma agent vemurafenib. Acs Chemical Biology. PMID 26061392 DOI: 10.1021/Acschembio.5B00174 |
0.328 |
|
| 2015 |
Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 6: 584-9. PMID 26005538 DOI: 10.1021/Acsmedchemlett.5B00064 |
0.683 |
|
| 2015 |
Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Human Molecular Genetics. 24: 4545-58. PMID 25994507 DOI: 10.1093/hmg/ddv185 |
0.788 |
|
| 2015 |
Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A. Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry. 58: 3751-6. PMID 25897865 DOI: 10.1021/Jm5018779 |
0.427 |
|
| 2015 |
Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR. Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2492-507. PMID 25673844 DOI: 10.1523/Jneurosci.4248-14.2015 |
0.466 |
|
| 2014 |
Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. The Biochemical Journal. 463: 413-27. PMID 25177796 DOI: 10.1042/Bj20140889 |
0.547 |
|
| 2014 |
Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nature Communications. 5: 4763. PMID 25159004 DOI: 10.1038/Ncomms5763 |
0.413 |
|
| 2014 |
Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Science Signaling. 7: re3. PMID 25028718 DOI: 10.1126/Scisignal.2005365 |
0.711 |
|
| 2014 |
Banerjee S, Zagórska A, Deak M, Campbell DG, Prescott AR, Alessi DR. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. The Biochemical Journal. 461: 233-45. PMID 24785407 DOI: 10.1042/Bj20140408 |
0.772 |
|
| 2014 |
Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. The Biochemical Journal. 460: 127-39. PMID 24660806 DOI: 10.1042/Bj20140334 |
0.546 |
|
| 2014 |
van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction. The Biochemical Journal. 460: 165-75. PMID 24650431 DOI: 10.1042/Bj20131639 |
0.503 |
|
| 2014 |
Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM. Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Open Biology. 4: 130213. PMID 24647965 DOI: 10.1098/Rsob.130213 |
0.436 |
|
| 2014 |
Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. The Biochemical Journal. 460: 237-46. PMID 24641320 DOI: 10.1042/Bj20140153 |
0.341 |
|
| 2014 |
de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. The Biochemical Journal. 458: 559-73. PMID 24393035 DOI: 10.1042/Bj20131478 |
0.755 |
|
| 2014 |
Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. The Biochemical Journal. 458: 41-56. PMID 24295069 DOI: 10.1042/Bj20131324 |
0.539 |
|
| 2014 |
Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. The Biochemical Journal. 457: 215-25. PMID 24171924 DOI: 10.1042/Bj20131152 |
0.797 |
|
| 2013 |
Voelkl J, Mia S, Meissner A, Ahmed MS, Feger M, Elvira B, Walker B, Alessi DR, Alesutan I, Lang F. PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction. Kidney & Blood Pressure Research. 38: 156-64. PMID 24685987 DOI: 10.1159/000355763 |
0.304 |
|
| 2013 |
Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry. 70: 758-67. PMID 24239623 DOI: 10.1016/J.Ejmech.2013.10.052 |
0.686 |
|
| 2013 |
Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G. N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling. The Journal of Biological Chemistry. 288: 31468-76. PMID 24043619 DOI: 10.1074/Jbc.M113.475574 |
0.522 |
|
| 2013 |
Alessi DR, Kulathu Y. Structural biology: Security measures of a master regulator. Nature. 497: 193-4. PMID 23636322 DOI: 10.1038/Nature12101 |
0.421 |
|
| 2013 |
Hardie DG, Alessi DR. LKB1 and AMPK and the cancer-metabolism link - ten years after. Bmc Biology. 11: 36. PMID 23587167 DOI: 10.1186/1741-7007-11-36 |
0.351 |
|
| 2013 |
Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR. Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. The Biochemical Journal. 452: 499-508. PMID 23581296 DOI: 10.1042/Bj20130342 |
0.497 |
|
| 2013 |
Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, ... ... Alessi DR, et al. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell. 23: 406-20. PMID 23453624 DOI: 10.1016/J.Ccr.2013.01.023 |
0.358 |
|
| 2013 |
Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. The Biochemical Journal. 451: 111-22. PMID 23387299 DOI: 10.1042/Bj20121903 |
0.383 |
|
| 2013 |
Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis. 76: 49-58. PMID 23313773 DOI: 10.1016/J.Jpba.2012.12.002 |
0.646 |
|
| 2013 |
Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM. Structural insights into the activation of MST3 by MO25. Biochemical and Biophysical Research Communications. 431: 604-9. PMID 23296203 DOI: 10.1016/J.Bbrc.2012.12.113 |
0.486 |
|
| 2013 |
Cohen P, Alessi DR. Kinase drug discovery--what's next in the field? Acs Chemical Biology. 8: 96-104. PMID 23276252 DOI: 10.1021/Cb300610S |
0.598 |
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| 2013 |
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics. 22: 328-44. PMID 23065705 DOI: 10.1093/Hmg/Dds431 |
0.7 |
|
| 2012 |
Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S. A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. Biology Open. 1: 120-7. PMID 23213404 DOI: 10.1242/Bio.2011048 |
0.436 |
|
| 2012 |
Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 3: 658-662. PMID 23066449 DOI: 10.1021/Ml300123A |
0.693 |
|
| 2012 |
Najafov A, Shpiro N, Alessi DR. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors. The Biochemical Journal. 448: 285-95. PMID 23030823 DOI: 10.1042/Bj20121287 |
0.554 |
|
| 2012 |
Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 60: 981-90. PMID 22949526 DOI: 10.1161/Hypertensionaha.112.201509 |
0.553 |
|
| 2012 |
Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, Gray NS. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 5625-9. PMID 22863203 DOI: 10.1016/J.Bmcl.2012.06.104 |
0.699 |
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| 2012 |
Landego I, Jayachandran N, Wullschleger S, Zhang TT, Gibson IW, Miller A, Alessi DR, Marshall AJ. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. European Journal of Immunology. 42: 2760-70. PMID 22777911 DOI: 10.1002/Eji.201242371 |
0.365 |
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| 2012 |
Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biology. 2: 120080. PMID 22724072 DOI: 10.1098/Rsob.120080 |
0.485 |
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| 2012 |
Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. Plos One. 7: e39132. PMID 22723946 DOI: 10.1371/Journal.Pone.0039132 |
0.765 |
|
| 2012 |
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nature Cell Biology. 14: 686-96. PMID 22609986 DOI: 10.1038/Ncb2507 |
0.536 |
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| 2012 |
Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proceedings of the National Academy of Sciences of the United States of America. 109: 7929-34. PMID 22550170 DOI: 10.1073/Pnas.1200947109 |
0.42 |
|
| 2012 |
Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, Alessi DR, Dunlop MG. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 142: 1504-15.e3. PMID 22406476 DOI: 10.1053/J.Gastro.2012.02.050 |
0.367 |
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| 2012 |
Zhang J, Deng X, Choi HG, Alessi DR, Gray NS. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 1864-9. PMID 22335897 DOI: 10.1016/J.Bmcl.2012.01.084 |
0.73 |
|
| 2012 |
Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. Clinical and Experimental Nephrology. 16: 530-8. PMID 22294159 DOI: 10.1007/S10157-012-0590-X |
0.324 |
|
| 2012 |
Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, ... ... Alessi DR, et al. Discovery of potent and selective covalent inhibitors of JNK. Chemistry & Biology. 19: 140-54. PMID 22284361 DOI: 10.1016/J.Chembiol.2011.11.010 |
0.701 |
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| 2012 |
Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. The Biochemical Journal. 441: 325-37. PMID 22032326 DOI: 10.1042/Bj20111879 |
0.556 |
|
| 2011 |
Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biology. 1: 110012. PMID 22645651 DOI: 10.1098/Rsob.110012 |
0.554 |
|
| 2011 |
Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. The Biochemical Journal. 437: 157-67. PMID 21548880 DOI: 10.1042/Bj20110276 |
0.755 |
|
| 2011 |
Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. Journal of Cell Science. 124: 1391-5. PMID 21486947 DOI: 10.1242/Jcs.084111 |
0.483 |
|
| 2011 |
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy. 7: 696-706. PMID 21460634 DOI: 10.4161/Auto.7.7.15451 |
0.551 |
|
| 2011 |
Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. The Embo Journal. 30: 1730-41. PMID 21423148 DOI: 10.1038/Emboj.2011.78 |
0.578 |
|
| 2011 |
Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. The Biochemical Journal. 436: 169-79. PMID 21413931 DOI: 10.1042/Bj20102103 |
0.564 |
|
| 2011 |
Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology. 7: 203-5. PMID 21378983 DOI: 10.1038/Nchembio.538 |
0.565 |
|
| 2011 |
Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. Journal of Cell Science. 124: 789-800. PMID 21321328 DOI: 10.1242/Jcs.077230 |
0.526 |
|
| 2011 |
Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. The Biochemical Journal. 434: 265-74. PMID 21204784 DOI: 10.1042/Bj20102012 |
0.303 |
|
| 2011 |
Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. The Biochemical Journal. 433: 357-69. PMID 21087210 DOI: 10.1042/Bj20101732 |
0.616 |
|
| 2011 |
Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance. Disease Models & Mechanisms. 4: 95-103. PMID 20959631 DOI: 10.1242/Jcs.086025 |
0.354 |
|
| 2010 |
Pozo-Guisado E, Campbell DG, Deak M, Alvarez-Barrientos A, Morrice NA, Alvarez IS, Alessi DR, Martín-Romero FJ. Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. Journal of Cell Science. 123: 3084-93. PMID 20736304 DOI: 10.1242/Jcs.067215 |
0.41 |
|
| 2010 |
Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). The Biochemical Journal. 431: 245-55. PMID 20704563 DOI: 10.1042/Bj20101024 |
0.54 |
|
| 2010 |
Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. The Biochemical Journal. 430: 405-13. PMID 20659021 DOI: 10.1042/Bj20100784 |
0.55 |
|
| 2010 |
Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. The Biochemical Journal. 430: 393-404. PMID 20642453 DOI: 10.1042/Bj20100483 |
0.447 |
|
| 2010 |
Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Science Signaling. 3: ra25. PMID 20354225 DOI: 10.1126/Scisignal.2000616 |
0.741 |
|
| 2010 |
Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. Embo Molecular Medicine. 2: 63-75. PMID 20091762 DOI: 10.1002/Emmm.200900058 |
0.726 |
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| 2010 |
Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. American Journal of Physiology. Endocrinology and Metabolism. 298: E761-9. PMID 20051528 DOI: 10.1152/Ajpendo.00421.2009 |
0.752 |
|
| 2010 |
Pearce LR, Komander D, Alessi DR. The nuts and bolts of AGC protein kinases. Nature Reviews. Molecular Cell Biology. 11: 9-22. PMID 20027184 DOI: 10.1038/Nrm2822 |
0.541 |
|
| 2009 |
Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (New York, N.Y.). 326: 1707-11. PMID 19892943 DOI: 10.1126/Science.1178377 |
0.5 |
|
| 2009 |
Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. The Biochemical Journal. 424: 47-60. PMID 19740074 DOI: 10.1042/Bj20091035 |
0.543 |
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| 2009 |
Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. Plos Biology. 7: e1000126. PMID 19513107 DOI: 10.1371/Journal.Pbio.1000126 |
0.413 |
|
| 2009 |
García-Martínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical Journal. 421: 29-42. PMID 19402821 DOI: 10.1042/Bj20090489 |
0.602 |
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| 2009 |
Alessi DR, Pearce LR, García-Martínez JM. New insights into mTOR signaling: mTORC2 and beyond. Science Signaling. 2: pe27. PMID 19383978 DOI: 10.1126/Scisignal.267Pe27 |
0.557 |
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| 2009 |
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 4384-9. PMID 19240212 DOI: 10.1073/Pnas.0813238106 |
0.599 |
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| 2009 |
Peifer C, Alessi DR. New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. The Biochemical Journal. 417: e5-7. PMID 19061482 DOI: 10.1042/Bj20082243 |
0.323 |
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| 2008 |
Peifer C, Alessi DR. Small-molecule inhibitors of PDK1. Chemmedchem. 3: 1810-38. PMID 18972468 DOI: 10.1002/Cmdc.200800195 |
0.456 |
|
| 2008 |
García-Martínez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). The Biochemical Journal. 416: 375-85. PMID 18925875 DOI: 10.1042/Bj20081668 |
0.594 |
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| 2008 |
Richardson C, Alessi DR. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. Journal of Cell Science. 121: 3293-304. PMID 18843116 DOI: 10.1242/Jcs.029223 |
0.431 |
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| 2008 |
Villa F, Deak M, Alessi DR, van Aalten DM. Structure of the OSR1 kinase, a hypertension drug target. Proteins. 73: 1082-7. PMID 18831043 DOI: 10.1002/Prot.22238 |
0.326 |
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| 2008 |
Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. The Journal of Biological Chemistry. 283: 27653-67. PMID 18669636 DOI: 10.1074/Jbc.M802623200 |
0.51 |
|
| 2008 |
Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC. PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response Cell Metabolism. 7: 291-301. PMID 18396135 DOI: 10.1016/J.Cmet.2008.01.006 |
0.328 |
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| 2008 |
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. The Biochemical Journal. 412: 211-21. PMID 18387000 DOI: 10.1042/Bj20080557 |
0.448 |
|
| 2008 |
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, ... ... Alessi DR, et al. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Molecular and Cellular Biology. 28: 3258-72. PMID 18347057 DOI: 10.1128/Mcb.02032-07 |
0.782 |
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| 2008 |
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. Journal of Cell Science. 121: 675-84. PMID 18270262 DOI: 10.1242/Jcs.025312 |
0.59 |
|
| 2008 |
Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. The Biochemical Journal. 411: 249-60. PMID 18254724 DOI: 10.1042/Bj20080067 |
0.576 |
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| 2007 |
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. The Biochemical Journal. 408: 297-315. PMID 17850214 DOI: 10.1042/Bj20070797 |
0.654 |
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| 2007 |
Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM. Structural insights into the recognition of substrates and activators by the OSR1 kinase. Embo Reports. 8: 839-45. PMID 17721439 DOI: 10.1038/Sj.Embor.7401048 |
0.467 |
|
| 2007 |
Pearce LR, Huang X, Boudeau J, Paw?owski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. The Biochemical Journal. 405: 513-22. PMID 17461779 DOI: 10.1042/Bj20070540 |
0.432 |
|
| 2007 |
Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. The Biochemical Journal. 405: 307-17. PMID 17447891 DOI: 10.1042/Bj20070209 |
0.561 |
|
| 2007 |
Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. The Journal of Cell Biology. 176: 89-100. PMID 17190791 DOI: 10.1083/Jcb.200605093 |
0.521 |
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| 2007 |
Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. The Biochemical Journal. 401: 29-38. PMID 17040210 DOI: 10.1042/Bj20061088 |
0.651 |
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| 2006 |
Budas GR, Sukhodub A, Alessi DR, Jovanović A. 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2556-8. PMID 17077284 DOI: 10.1096/Fj.06-6252Fje |
0.422 |
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| 2006 |
Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR. Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. Journal of Cell Science. 119: 4059-70. PMID 16968750 DOI: 10.1242/Jcs.03097 |
0.484 |
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| 2006 |
Bayascas JR, Sakamoto K, Armit L, Arthur JS, Alessi DR. Evaluation of approaches to generation of tissue-specific knock-in mice. The Journal of Biological Chemistry. 281: 28772-81. PMID 16887794 DOI: 10.1074/Jbc.M606789200 |
0.695 |
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| 2006 |
Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR. Emerging roles of pseudokinases. Trends in Cell Biology. 16: 443-52. PMID 16879967 DOI: 10.1016/J.Tcb.2006.07.003 |
0.511 |
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| 2006 |
Sandu C, Artunc F, Palmada M, Rexhepaj R, Grahammer F, Hussain A, Yun C, Alessi DR, Lang F. Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse. American Journal of Physiology. Gastrointestinal and Liver Physiology. 291: G868-76. PMID 16825708 DOI: 10.1152/Ajpgi.00023.2006 |
0.375 |
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| 2006 |
Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent signaling pathways Annual Review of Biochemistry. 75: 137-163. PMID 16756488 DOI: 10.1146/Annurev.Biochem.75.103004.142702 |
0.758 |
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| 2006 |
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HKR, Alessi DR. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 Biochemical Journal. 397: 223-231. PMID 16669787 DOI: 10.1042/Bj20060220 |
0.513 |
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| 2006 |
Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DMF, Alessi DR. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation Biochemical Journal. 394: 545-555. PMID 16396636 DOI: 10.1042/Bj20051844 |
0.558 |
|
| 2005 |
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK Journal of Cell Science. 118: 5661-5673. PMID 16306228 DOI: 10.1242/Jcs.02670 |
0.519 |
|
| 2005 |
Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Current Biology : Cb. 15: 1839-46. PMID 16243031 DOI: 10.1016/J.Cub.2005.08.066 |
0.736 |
|
| 2005 |
Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR. In vivo role of the phosphate groove of PDK1 defined by knockin mutation. Journal of Cell Science. 118: 5023-34. PMID 16219676 DOI: 10.1242/Jcs.02617 |
0.566 |
|
| 2005 |
Lipina C, Huang X, Finlay D, McManus EJ, Alessi DR, Sutherland C. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3 Biochemical Journal. 392: 633-639. PMID 16176184 DOI: 10.1042/Bj20051046 |
0.302 |
|
| 2005 |
Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases Biochemical Journal. 391: 17-24. PMID 16083423 DOI: 10.1042/Bj20051180 |
0.578 |
|
| 2005 |
Mora A, Sakamoto K, McManus EJ, Alessi DR. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart Febs Letters. 579: 3632-3638. PMID 15961082 DOI: 10.1016/J.Febslet.2005.05.040 |
0.303 |
|
| 2005 |
Bayascas JR, Alessi DR. Regulation of Akt/PKB Ser473 phosphorylation Molecular Cell. 18: 143-145. PMID 15837416 DOI: 10.1016/J.Molcel.2005.03.020 |
0.727 |
|
| 2005 |
McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, Alessi DR. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. The Embo Journal. 24: 1571-83. PMID 15791206 DOI: 10.1038/Sj.Emboj.7600633 |
0.423 |
|
| 2005 |
Komander D, Kular G, Deak M, Alessi DR, Van Aalten DMF. Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding Journal of Biological Chemistry. 280: 18797-18802. PMID 15741170 DOI: 10.1074/Jbc.M500977200 |
0.425 |
|
| 2005 |
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate Febs Letters. 579: 1417-1423. PMID 15733851 DOI: 10.1016/J.Febslet.2005.01.042 |
0.557 |
|
| 2005 |
Dümmler BA, Hauge C, Silber J, Yntema HG, Kruse LS, Kofoed B, Hemmings BA, Alessi DR, Frödin M. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types Journal of Biological Chemistry. 280: 13304-13314. PMID 15632195 DOI: 10.1074/Jbc.M408194200 |
0.559 |
|
| 2004 |
Schutkowski M, Reimer U, Panse S, Dong L, Lizcano JM, Alessi DR, Schneider-Mergener J. High-content peptide microarrays for deciphering kinase specificity and biology. Angewandte Chemie (International Ed. in English). 43: 2671-4. PMID 18629986 DOI: 10.1002/Anie.200453900 |
0.315 |
|
| 2004 |
Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. The Journal of Biological Chemistry. 280: 8180-7. PMID 15611135 DOI: 10.1074/Jbc.M412211200 |
0.404 |
|
| 2004 |
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Analysis of the LKB1-STRAD-MO25 complex. Journal of Cell Science. 117: 6365-75. PMID 15561763 DOI: 10.1242/Jcs.01571 |
0.441 |
|
| 2004 |
Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Downes CP, Safrany ST, Alessi DR, Van Aalten DMF. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates Embo Journal. 23: 3918-3928. PMID 15457207 DOI: 10.1038/Sj.Emboj.7600379 |
0.358 |
|
| 2004 |
Mora A, Komander D, Van Aalten DMF, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction Seminars in Cell and Developmental Biology. 15: 161-170. PMID 15209375 DOI: 10.1016/J.Semcdb.2003.12.022 |
0.573 |
|
| 2004 |
McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. The Embo Journal. 23: 2071-82. PMID 15116068 DOI: 10.1038/Sj.Emboj.7600218 |
0.452 |
|
| 2004 |
Hinton HJ, Alessi DR, Cantrell DA. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development Nature Immunology. 5: 539-545. PMID 15077109 DOI: 10.1038/Ni1062 |
0.478 |
|
| 2004 |
Sakamoto K, Göransson O, Hardie DG, Alessi DR. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR American Journal of Physiology - Endocrinology and Metabolism. 287: E310-E317. PMID 15068958 DOI: 10.1152/Ajpendo.00074.2004 |
0.405 |
|
| 2004 |
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 Embo Journal. 23: 833-843. PMID 14976552 DOI: 10.1038/Sj.Emboj.7600110 |
0.579 |
|
| 2004 |
Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KRC, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, Van Aalten DMF. Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1 Structure. 12: 215-226. PMID 14962382 DOI: 10.1016/J.Str.2004.01.005 |
0.467 |
|
| 2004 |
Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate Biochemical Journal. 378: 257-268. PMID 14611643 DOI: 10.1042/Bj20031692 |
0.618 |
|
| 2003 |
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. The Embo Journal. 22: 5102-14. PMID 14517248 DOI: 10.1093/Emboj/Cdg490 |
0.317 |
|
| 2003 |
Kimber WA, Deak M, Prescott AR, Alessi DR. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1 Biochemical Journal. 376: 525-535. PMID 14516276 DOI: 10.1042/Bj20031154 |
0.37 |
|
| 2003 |
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of Biology. 2: 28. PMID 14511394 DOI: 10.1186/1475-4924-2-28 |
0.398 |
|
| 2003 |
Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. The Biochemical Journal. 375: 531-8. PMID 12964941 DOI: 10.1042/Bj20031229 |
0.311 |
|
| 2003 |
Collins BJ, Deak M, Arthur JSC, Armit LJ, Alessi DR. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation Embo Journal. 22: 4202-4211. PMID 12912918 DOI: 10.1093/Emboj/Cdg407 |
0.524 |
|
| 2003 |
Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DMF. Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition Biochemical Journal. 375: 255-262. PMID 12892559 DOI: 10.1042/Bj20031119 |
0.55 |
|
| 2003 |
Lizcano JM, Alrubaie S, Kieloch A, Deak M, Leevers SJ, Alessi DR. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B Biochemical Journal. 374: 297-306. PMID 12841848 DOI: 10.1042/Bj20030577 |
0.434 |
|
| 2003 |
Boudeau J, Sapkota G, Alessi DR. LKB1, a protein kinase regulating cell proliferation and polarity Febs Letters. 546: 159-165. PMID 12829253 DOI: 10.1016/S0014-5793(03)00642-2 |
0.402 |
|
| 2003 |
Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation Journal of Biological Chemistry. 278: 8199-8211. PMID 12510059 DOI: 10.1074/Jbc.M209153200 |
0.405 |
|
| 2003 |
Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. The Biochemical Journal. 370: 849-57. PMID 12489981 DOI: 10.1042/Bj20021813 |
0.401 |
|
| 2002 |
Hamm J, Alessi DR, Biondi RM. Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase Journal of Biological Chemistry. 277: 45793-45802. PMID 12235136 DOI: 10.1074/Jbc.M205072200 |
0.505 |
|
| 2002 |
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical Journal. 368: 507-16. PMID 12234250 DOI: 10.1042/Bj20021284 |
0.546 |
|
| 2002 |
McManus EJ, Alessi DR. TSC1-TSC2: A complex tale of PKB-mediated S6K regulation Nature Cell Biology. 4: E214-E216. PMID 12205484 DOI: 10.1038/Ncb0902-E214 |
0.508 |
|
| 2002 |
Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. The Biochemical Journal. 368: 243-51. PMID 12186630 DOI: 10.1042/Bj20020973 |
0.301 |
|
| 2002 |
Thomas CC, Deak M, Alessi DR, Van Aalten DMF. High-resolution structure of the pleckstrin homology domain of protein kinase B/Akt bound to phosphatidylinositol (3,4,5)-trisphosphate Current Biology. 12: 1256-1262. PMID 12176338 DOI: 10.1016/S0960-9822(02)00972-7 |
0.304 |
|
| 2002 |
Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, Van Aalten DMF. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site Embo Journal. 21: 4219-4228. PMID 12169624 DOI: 10.1093/Emboj/Cdf437 |
0.482 |
|
| 2002 |
Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, Polakiewicz RD, Comb MJ. Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. The Journal of Biological Chemistry. 277: 39379-87. PMID 12151408 DOI: 10.1074/Jbc.M206399200 |
0.462 |
|
| 2002 |
Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. Essential role of PDK1 in regulating cell size and development in mice. The Embo Journal. 21: 3728-38. PMID 12110585 DOI: 10.1093/Emboj/Cdf387 |
0.328 |
|
| 2002 |
Lizcano JM, Deak M, Morrice N, Kieloch A, James Hastie C, Dong L, Schutkowski M, Reimer U, Alessi DR. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo Journal of Biological Chemistry. 277: 27839-27849. PMID 12023960 DOI: 10.1074/Jbc.M202042200 |
0.584 |
|
| 2002 |
Lizcano JM, Alessi DR. The insulin signalling pathway Current Biology. 12: R236. PMID 11937037 DOI: 10.1016/S0960-9822(02)00777-7 |
0.36 |
|
| 2002 |
Sapkota GP, Boubeau J, Deak M, Kieloch A, Morrice N, Alessi DR. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr366 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome Biochemical Journal. 362: 481-490. PMID 11853558 DOI: 10.1042/0264-6021:3620481 |
0.526 |
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