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Masayuki Yamamoto - Publications

Affiliations: 
Graduate School of Science The University of Tokyo 
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Year Citation  Score
2020 Baird L, Suzuki T, Takahashi Y, Hishinuma E, Saigusa D, Yamamoto M. Geldanamycin-derived HSP90 Inhibitors are Synthetic Lethal with NRF2. Molecular and Cellular Biology. PMID 32868290 DOI: 10.1128/Mcb.00377-20  0.306
2020 Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K. Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging. Plos One. 15: e0236834. PMID 32780748 DOI: 10.1371/Journal.Pone.0236834  0.319
2020 Hayashi M, Kuga A, Suzuki M, Panda H, Kitamura H, Motohashi H, Yamamoto M. Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors. Cancer Research. PMID 32636316 DOI: 10.1158/0008-5472.Can-19-2888  0.347
2020 Ashino T, Yamamoto M, Numazawa S. Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-deficient Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32503880 DOI: 10.1124/Dmd.120.000010  0.385
2020 Yamaoka A, Suzuki M, Katayama S, Orihara D, Engel JD, Yamamoto M. EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. Blood Advances. 4: 1722-1736. PMID 32330245 DOI: 10.1182/Bloodadvances.2019000978  0.317
2020 Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. Plos Genetics. 16: e1008693. PMID 32324833 DOI: 10.1371/Journal.Pgen.1008693  0.396
2020 Baird L, Yamamoto M. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway. Molecular and Cellular Biology. PMID 32284348 DOI: 10.1128/Mcb.00099-20  0.354
2020 Aoki Y, Taniguchi Y, Matsumoto M, Matsumoto M, Ohno M, Masumura K, Sasaki S, Tsuzuki T, Yamamoto M, Nohmi T. Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate. Mutation Research. 850: 503136. PMID 32247553 DOI: 10.1016/J.Mrgentox.2020.503136  0.301
2020 Shichino Y, Otsubo Y, Yamamoto M, Yamashita A. Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1. Plos Genetics. 16: e1008598. PMID 32012158 DOI: 10.1371/Journal.Pgen.1008598  0.344
2020 Nabeshima T, Hamada S, Taguchi K, Tanaka Y, Matsumoto R, Yamamoto M, Masamune A. Keap1 deletion accelerates mutant K-ras/p53-driven cholangiocarcinoma. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31961719 DOI: 10.1152/Ajpgi.00296.2019  0.421
2020 Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M. Nrf2 Suppresses Oxidative Stress and Inflammation in Knock-in Alzheimer's Disease Model Mice. Molecular and Cellular Biology. PMID 31932477 DOI: 10.1128/Mcb.00467-19  0.336
2020 Yagishita Y, Uruno A, Kensler TW, Yamamoto M. SUN-LB101 NRF2 Represses Obesity-Associated Adipose Tissue Inflammation in Mice Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.2014  0.318
2019 Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H, Yamamoto M. Impacts of NRF2 Activation in Non-Small-Cell Lung Cancer Cell Lines on Extracellular Metabolites. Cancer Science. PMID 31828882 DOI: 10.1111/Cas.14278  0.321
2019 Otsuki A, Yamamoto M. Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases. Archives of Pharmacal Research. PMID 31792803 DOI: 10.1007/S12272-019-01193-2  0.342
2019 Shimizu R, Yamamoto M. Quantitative and qualitative impairments in GATA2 and myeloid neoplasms. Iubmb Life. PMID 31675473 DOI: 10.1002/Iub.2188  0.348
2019 Takai J, Ohtsu H, Sato A, Uemura S, Fujimura T, Yamamoto M, Moriguchi T. Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice. Scientific Reports. 9: 15603. PMID 31666556 DOI: 10.1038/S41598-019-51716-6  0.388
2019 Ohneda K, Ohmori S, Yamamoto M. Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells. International Journal of Molecular Sciences. 20. PMID 31533351 DOI: 10.3390/Ijms20184603  0.424
2019 Ohmori S, Ishijima Y, Numata S, Takahashi M, Sekita M, Sato T, Chugun K, Yamamoto M, Ohneda K. GATA2 and PU.1 collaborate to activate the expression of the mouse gene encoding FcϵRIβ through distinct mechanisms. Molecular and Cellular Biology. PMID 31501274 DOI: 10.1128/Mcb.00314-19  0.41
2019 Nagasu H, Sogawa Y, Kidokoro K, Itano S, Yamamoto T, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Wigley WC, Proksch JW, Meyer CJ, Kashihara N. Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900217R. PMID 31431054 DOI: 10.1096/Fj.201900217R  0.311
2019 Panda H, Keleku-Lukwete N, Kuga A, Fuke N, Suganuma H, Suzuki M, Yamamoto M. Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model. Experimental Hematology. PMID 31404577 DOI: 10.1016/J.Exphem.2019.08.001  0.371
2019 Katsuoka F, Otsuki A, Takahashi M, Ito S, Yamamoto M. Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells. Molecular and Cellular Biology. PMID 31383749 DOI: 10.1128/Mcb.00273-19  0.375
2019 Edamitsu T, Taguchi K, Kobayashi EH, Okuyama R, Yamamoto M. Aryl Hydrocarbon Receptor Directly Regulates Gene Expression. Molecular and Cellular Biology. PMID 31358547 DOI: 10.1128/Mcb.00190-19  0.395
2019 Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K, Baird L, Yamamoto M. Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. Cell Reports. 28: 746-758.e4. PMID 31315052 DOI: 10.1016/J.Celrep.2019.06.047  0.32
2019 Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y. Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both. Environmental Health Perspectives. 127: 67002. PMID 31166132 DOI: 10.1289/Ehp4949  0.341
2019 Hoshino T, Terunuma T, Takai J, Uemura S, Nakamura Y, Hamada M, Takahashi S, Yamamoto M, Engel JD, Moriguchi T. Spiral ganglion cell degeneration-induced deafness as a consequence of reduced GATA factor activity. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 31141264 DOI: 10.1111/Gtc.12705  0.366
2019 Keleku-Lukwete N, Suzuki M, Panda H, Otsuki A, Katsuoka F, Saito R, Saigusa D, Uruno A, Yamamoto M. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood Advances. 3: 1285-1297. PMID 31015205 DOI: 10.1182/Bloodadvances.2018017574  0.38
2019 Liu Z, Hou Y, Li L, Yang Y, Jia J, Hong Z, Li T, Xu Y, Fu J, Sun Y, Yamamoto M, Wang H, Pi J. Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic. Toxicology and Applied Pharmacology. PMID 30742845 DOI: 10.1016/J.Taap.2019.02.003  0.321
2019 Harada N, Hasegawa A, Hirano I, Yamamoto M, Shimizu R. GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. Cancer Science. PMID 30710465 DOI: 10.1111/Cas.13959  0.382
2019 Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, Kumaki S, Miyazaki Y, Motohashi H, Yamamoto M, Tanaka N. Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response. Journal of Immunology (Baltimore, Md. : 1950). PMID 30674574 DOI: 10.4049/Jimmunol.1801180  0.347
2019 Saito K, Fujiwara T, Hatta S, Morita M, Ono K, Suzuki C, Fukuhara N, Onishi Y, Nakamura Y, Kawamata S, Shimizu R, Yamamoto M, Harigae H. Generation and Molecular Characterization of Human Ring Sideroblasts: A Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation. Molecular and Cellular Biology. PMID 30670569 DOI: 10.1128/Mcb.00387-18  0.346
2019 Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M. Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice. The Journal of Endocrinology. PMID 30625116 DOI: 10.1530/Joe-18-0355  0.307
2018 Cho HY, Miller-DeGraff L, Blankenship-Paris T, Wang X, Bell DA, Lih F, Deterding L, Panduri V, Morgan DL, Yamamoto M, Reddy AJ, Talalay P, Kleeberger SR. Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice. Toxicology and Applied Pharmacology. PMID 30529165 DOI: 10.1016/J.Taap.2018.12.004  0.355
2018 Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H. Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding. Plos One. 13: e0203978. PMID 30500824 DOI: 10.1371/Journal.Pone.0203978  0.3
2018 Sun J, Fu J, Zhong Y, Li L, Chen C, Wang X, Wang L, Hou Y, Wang H, Zhao R, Zhang X, Yamamoto M, Xu Y, Pi J. NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30248482 DOI: 10.1016/J.Fct.2018.09.042  0.305
2018 Taguchi K, Masui S, Itoh T, Miyajima A, Yamamoto M. Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30215777 DOI: 10.1093/Toxsci/Kfy233  0.346
2018 Moriguchi T, Hoshino T, Rao A, Yu L, Takai J, Uemura S, Ise K, Nakamura Y, Lim KC, Shimizu R, Yamamoto M, Engel JD. A 3' distal otic vesicle enhancer directs inner ear-specific expression. Molecular and Cellular Biology. PMID 30126893 DOI: 10.1128/Mcb.00302-18  0.368
2018 Rojo AI, Pajares M, García-Yagüe AJ, Buendia I, Van Leuven F, Yamamoto M, López MG, Cuadrado A. Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biology. 18: 173-180. PMID 30029164 DOI: 10.1016/J.Redox.2018.07.006  0.336
2018 Sekine H, Okazaki K, Kato K, Alam MM, Shima H, Katsuoka F, Tsujita T, Suzuki N, Kobayashi A, Igarashi K, Yamamoto M, Motohashi H. -GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1. Molecular and Cellular Biology. PMID 29941490 DOI: 10.1128/Mcb.00252-18  0.341
2018 Hou Y, Liu Z, Zuo Z, Gao T, Fu J, Wang H, Xu Y, Liu D, Yamamoto M, Zhu B, Zhang Y, Andersen ME, Zhang Q, Pi J. Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice. Biochemical and Biophysical Research Communications. PMID 29935181 DOI: 10.1016/J.Bbrc.2018.06.013  0.326
2018 Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa Y, Hase K, Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, et al. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29907708 DOI: 10.4049/Jimmunol.1800040  0.343
2018 Anusornvongchai T, Nangaku M, Jao TM, Wu CH, Ishimoto Y, Maekawa H, Tanaka T, Shimizu A, Yamamoto M, Suzuki N, Sassa R, Inagi R. Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response. Kidney International. PMID 29887316 DOI: 10.1016/J.Kint.2018.03.011  0.377
2018 Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. Scientific Reports. 8: 8037. PMID 29795117 DOI: 10.1038/S41598-018-26269-9  0.322
2018 Hishinuma E, Narita Y, Saito S, Maekawa M, Akai F, Nakanishi Y, Yasuda J, Nagasaki M, Yamamoto M, Yamaguchi H, Mano N, Hirasawa N, Hiratsuka M. Functional characterization of 21 allelic variants of dihydropyrimidine dehydrogenase identified in 1,070 Japanese individuals. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29769267 DOI: 10.1124/Dmd.118.081737  0.31
2018 Ziros PG, Habeos I, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, et al. The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland. Thyroid : Official Journal of the American Thyroid Association. PMID 29742982 DOI: 10.1089/Thy.2018.0018  0.323
2018 Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. Physiological Reviews. 98: 1169-1203. PMID 29717933 DOI: 10.1152/Physrev.00023.2017  0.37
2018 Naidu SD, Suzuki T, Yamamoto M, Fahey JW, Dinkova-Kostova AT. Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1. Molecular Nutrition & Food Research. e1700908. PMID 29710398 DOI: 10.1002/Mnfr.201700908  0.326
2018 Yoshida E, Suzuki T, Morita M, Taguchi K, Tsuchida K, Motohashi H, Doita M, Yamamoto M. Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 29542224 DOI: 10.1111/Gtc.12579  0.331
2018 Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. PMID 29472449 DOI: 10.1073/Pnas.1714056115  0.345
2018 Shichino Y, Otsubo Y, Kimori Y, Yamamoto M, Yamashita A. YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci. Elife. 7. PMID 29424342 DOI: 10.7554/Elife.32155  0.365
2018 Otsubo Y, Matsuo T, Nishimura A, Yamamoto M, Yamashita A. tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway. Embo Reports. PMID 29330317 DOI: 10.15252/Embr.201744867  0.301
2018 Lukwete NK, Suzuki M, Panda H, Otsuki A, Katsuoka F, Saitou R, Saigusa D, Uruno A, Yamamoto M. How KEAP1 Deletion in Single Cell Mitigates Sickle Cell Pathology Blood. 132: 2353-2353. DOI: 10.1182/Blood-2018-99-110502  0.348
2017 Hamada S, Taguchi K, Masamune A, Yamamoto M, Shimosegawa T. Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis. Carcinogenesis. 38: 661-670. PMID 29240881 DOI: 10.1093/Carcin/Bgx043  0.31
2017 Kaneko H, Katoh T, Hirano I, Hasegawa A, Tsujita T, Yamamoto M, Shimizu R. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 29044949 DOI: 10.1111/Gtc.12537  0.4
2017 Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J. Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles. Scientific Reports. 7: 12902. PMID 29018242 DOI: 10.1038/S41598-017-12926-Y  0.319
2017 Hamada S, Shimosegawa T, Taguchi K, Nabeshima T, Yamamoto M, Masamune A. Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00228.2017. PMID 28971839 DOI: 10.1152/Ajpgi.00228.2017  0.345
2017 Keleku-Lukwete N, Suzuki M, Yamamoto M. An overview of the advantages of KEAP1-NRF2 system activation during inflammatory disease treatment. Antioxidants & Redox Signaling. PMID 28899203 DOI: 10.1089/Ars.2017.7358  0.355
2017 Hasegawa S, Fujiwara T, Okitsu Y, Kato H, Sato Y, Fukuhara N, Onishi Y, Shimizu R, Yamamoto M, Harigae H. Effects of in vivo deletion of GATA2 in bone marrow stromal cells. Experimental Hematology. PMID 28866324 DOI: 10.1016/J.Exphem.2017.08.004  0.357
2017 Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, ... ... Yamamoto M, et al. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data. 4: 170112. PMID 28850106 DOI: 10.1038/Sdata.2017.112  0.331
2017 Suzuki T, Yamamoto M. Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. The Journal of Biological Chemistry. PMID 28842501 DOI: 10.1074/Jbc.R117.800169  0.343
2017 Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Scientific Reports. 7: 8801. PMID 28821730 DOI: 10.1038/S41598-017-08054-2  0.334
2017 Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, Saya H, Yamamoto M, Shimizu R. Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury. Molecular and Cellular Biology. PMID 28807932 DOI: 10.1128/Mcb.00211-17  0.317
2017 Touat-Todeschini L, Shichino Y, Dangin M, Thierry-Mieg N, Gilquin B, Hiriart E, Sachidanandam R, Lambert E, Brettschneider J, Reuter M, Kadlec J, Pillai R, Yamashita A, Yamamoto M, Verdel A. Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation. The Embo Journal. PMID 28765164 DOI: 10.15252/Embj.201796571  0.354
2017 Yamashita A, Sakuno T, Watanabe Y, Yamamoto M. Analysis of Schizosaccharomyces pombe Meiosis. Cold Spring Harbor Protocols. PMID 28733417 DOI: 10.1101/Pdb.Top079855  0.346
2017 Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Redox Biology. 13: 444-451. PMID 28704727 DOI: 10.1016/J.Redox.2017.07.006  0.331
2017 Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H. NRF2 activation impairs quiescence and bone marrow reconstitution capacity of hematopoietic stem cells. Molecular and Cellular Biology. PMID 28674188 DOI: 10.1128/Mcb.00086-17  0.335
2017 Katayama S, Suzuki M, Yamaoka A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kure S, Engel JD, Yamamoto M. GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. Blood. PMID 28630119 DOI: 10.1182/Blood-2016-12-756767  0.36
2017 Taguchi K, Yamamoto M. The KEAP1-NRF2 System in Cancer. Frontiers in Oncology. 7: 85. PMID 28523248 DOI: 10.3389/Fonc.2017.00085  0.305
2017 Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28515152 DOI: 10.1096/Fj.201700177R  0.412
2017 Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZ, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T, Hozawa A, Karumanchi SA, Suzuki N, Yamamoto M. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Science Signaling. 10. PMID 28512147 DOI: 10.1126/Scisignal.Aam5711  0.357
2017 Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H. Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice. Molecular and Cellular Biology. PMID 28507037 DOI: 10.1128/Mcb.00063-17  0.374
2017 Nezu M, Suzuki N, Yamamoto M. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression. American Journal of Nephrology. 45: 473-483. PMID 28502971 DOI: 10.1159/000475890  0.344
2017 Li YJ, Shimizu T, Shinkai Y, Hirata Y, Inagaki H, Takeda K, Azuma A, Yamamoto M, Kawada T. Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice. International Journal of Molecular Sciences. 18. PMID 28304344 DOI: 10.3390/Ijms18030649  0.315
2017 Suzuki N, Gradin K, Poellinger L, Yamamoto M. Regulation of hypoxia-inducible gene expression after HIF activation. Experimental Cell Research. PMID 28286304 DOI: 10.1016/J.Yexcr.2017.03.013  0.403
2017 Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M. The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice. European Journal of Pharmacology. PMID 28246026 DOI: 10.1016/J.Ejphar.2017.02.044  0.357
2017 Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi EH, Yamaoka A, Baird L, Takahashi N, Sato H, Yamamoto M. Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus. Nature Communications. 8: 14577. PMID 28233855 DOI: 10.1038/Ncomms14577  0.367
2017 Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, Yamamoto M. Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell Reports. 18: 2030-2044. PMID 28228267 DOI: 10.1016/J.Celrep.2017.01.064  0.321
2017 Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M. Derepression of the DNA methylation machinery of Gata1 gene triggers the differentiation cue for erythropoiesis. Molecular and Cellular Biology. PMID 28069743 DOI: 10.1128/Mcb.00592-16  0.407
2016 Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radical Biology & Medicine. PMID 28039084 DOI: 10.1016/J.Freeradbiomed.2016.12.041  0.364
2016 Baird L, Tsujita T, Kobayashi E, Funayama R, Nagashima T, Nakayama K, Yamamoto M. A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Molecular and Cellular Biology. PMID 27920251 DOI: 10.1128/Mcb.00439-16  0.393
2016 Hirano I, Suzuki N, Yamazaki S, Sekine H, Minegishi N, Shimizu R, Yamamoto M. Renal Anemia Model Mouse Established by Transgenic Rescue with Erythropoietin Gene Lacking Kidney-specific Regulatory Elements. Molecular and Cellular Biology. PMID 27920250 DOI: 10.1128/Mcb.00451-16  0.371
2016 Hidaka T, Ogawa E, Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Fujimura T, Aiba S, Nakayama K, Okuyama R, Yamamoto M. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature Immunology. PMID 27869817 DOI: 10.1038/Ni.3614  0.324
2016 Ano S, Panariti A, Allard B, O'Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Yamamoto M, Powell WS, Martin JG. Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice. Free Radical Biology & Medicine. PMID 27847240 DOI: 10.1016/J.Freeradbiomed.2016.11.017  0.335
2016 Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney International. PMID 27789056 DOI: 10.1016/J.Kint.2016.08.023  0.314
2016 Katsuoka F, Yamazaki H, Yamamoto M. Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 27723178 DOI: 10.1111/Gtc.12445  0.37
2016 Iso T, Suzuki T, Baird L, Yamamoto M. Absolute Amounts and Status of Nrf2-Keap1-Cul3 Complex within Cells. Molecular and Cellular Biology. PMID 27697860 DOI: 10.1128/Mcb.00389-16  0.362
2016 Nezu M, Souma T, Yu L, Sekine H, Moriguchi T, Takahashi N, Ito S, Suzuki N, Yamamoto M. OS 05-05 Nrf2 DEFICIENCY ALLEVIATES PERINATAL COMPLICATIONS IN PREGNANCY-ASSOCIATED HYPERTENSION MICE VIA ENHANCING PLACENTAL ANGIOGENESIS. Journal of Hypertension. 34: e59. PMID 27643323 DOI: 10.1097/01.Hjh.0000500005.64305.C1  0.328
2016 Chen Y, Xu Y, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J. The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study. Biochemical and Biophysical Research Communications. PMID 27453341 DOI: 10.1016/J.Bbrc.2016.07.088  0.372
2016 Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 0. PMID 27427974 DOI: 10.1080/15548627.2016.1208889  0.37
2016 Moriguchi T, Yu L, Otsuki A, Ainoya K, Lim KC, Yamamoto M, Engel JD. Gata3 hypomorphic mutant mice rescued with a YAC transgene suffer a glomerular mesangial cell defect. Molecular and Cellular Biology. PMID 27296697 DOI: 10.1128/Mcb.00173-16  0.319
2016 Onodera K, Fujiwara T, Onishi Y, Itoh-Nakadai A, Okitsu Y, Fukuhara N, Ishizawa K, Shimizu R, Yamamoto M, Harigae H. GATA2 regulates dendritic cell differentiation. Blood. PMID 27259979 DOI: 10.1182/Blood-2016-02-698118  0.324
2016 Shimizu R, Yamamoto M. GATA-related Hematological Disorders. Experimental Hematology. PMID 27235756 DOI: 10.1016/J.Exphem.2016.05.010  0.373
2016 Hasegawa A, Kaneko H, Ishihara D, Nakamura M, Watanabe A, Yamamoto M, Trainor CD, Shimizu R. GATA1 binding kinetics on conformation-specific binding sites elicit differential transcriptional regulation. Molecular and Cellular Biology. PMID 27215385 DOI: 10.1128/Mcb.00017-16  0.334
2016 Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Communications. 7: 11624. PMID 27211851 DOI: 10.1038/Ncomms11624  0.3
2016 Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of A New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27071940 DOI: 10.1093/Toxsci/Kfw065  0.307
2016 Katsuoka F, Yamamoto M. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. PMID 27058431 DOI: 10.1016/J.Gene.2016.03.058  0.319
2016 Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M. Nrf2-mediated regulation of skeletal muscle glycogen metabolism. Molecular and Cellular Biology. PMID 27044864 DOI: 10.1128/Mcb.01095-15  0.309
2016 Satoh H, Moriguchi T, Saigusa D, Baird L, Yu L, Rokutan H, Igarashi K, Ebina M, Shibata T, Yamamoto M. NRF2 intensifies host defense systems to prevent lung carcinogenesis, but after tumor initiation accelerates malignant cell growth. Cancer Research. PMID 27020858 DOI: 10.1158/0008-5472.Can-15-1584  0.35
2016 Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T. Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. Toxicology and Applied Pharmacology. PMID 26827822 DOI: 10.1016/J.Taap.2016.01.020  0.345
2016 Keleku-Lukwete N, Harit P, Naganuma E, Suzuki M, Yamamoto M. Specific Deletion of Keap1 in Endothelial Cells or/and Macrophages of SCD Mice Induces Nrf2 to Protect Tissues Against Oxidative Insults Blood. 128: 2475-2475. DOI: 10.1182/Blood.V128.22.2475.2475  0.348
2016 Suzuki M, Otsuki A, Keleku-Lukwete N, Yamamoto M. Overview of redox regulation by Keap1–Nrf2 system in toxicology and cancer Current Opinion in Toxicology. 1: 29-36. DOI: 10.1016/J.Cotox.2016.10.001  0.35
2015 Slocum SL, Skoko JJ, Wakabayashi N, Aja S, Yamamoto M, Kensler TW, Chartoumpekis DV. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. Archives of Biochemistry and Biophysics. PMID 26701603 DOI: 10.1016/J.Abb.2015.11.040  0.32
2015 Otsuki A, Suzuki M, Katsuoka F, Tsuchida K, Suda H, Morita M, Shimizu R, Yamamoto M. Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection. Free Radical Biology & Medicine. PMID 26677805 DOI: 10.1016/J.Freeradbiomed.2015.12.005  0.339
2015 Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K. The Transcription Factor Bach2 is Phosphorylated at Multiple Sites in Murine B Cells But a Single Site Prevents Its Nuclear Localization. The Journal of Biological Chemistry. PMID 26620562 DOI: 10.1074/Jbc.M115.661702  0.309
2015 Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M. The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1. Science Signaling. 8: ra120. PMID 26602019 DOI: 10.1126/Scisignal.Aad0667  0.31
2015 Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M. The Mediator Subunit MED16 Transduces NRF2-activating Signals into Antioxidant Gene Expression. Molecular and Cellular Biology. PMID 26572828 DOI: 10.1128/Mcb.00785-15  0.373
2015 Takeuchi M, Fuse Y, Watanabe M, Andrea CS, Takeuchi M, Nakajima H, Ohashi K, Kaneko H, Kobayashi-Osaki M, Yamamoto M, Kobayashi M. LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512114 DOI: 10.1073/Pnas.1517326112  0.336
2015 Suzuki N, Yamamoto M. Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. Pflugers Archiv : European Journal of Physiology. PMID 26452589 DOI: 10.1007/S00424-015-1740-2  0.328
2015 Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH. Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clinical Epigenetics. 7: 102. PMID 26388957 DOI: 10.1186/S13148-015-0132-Y  0.341
2015 Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, Imaizumi M, Yamamoto M. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26371321 DOI: 10.1073/Pnas.1509158112  0.356
2015 Santoso A, Kikuchi T, Tode N, Hirano T, Komatsu R, Damayanti T, Motohashi H, Yamamoto M, Kojima T, Uede T, Nukiwa T, Ichinose M. Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26307669 DOI: 10.1038/Mt.2015.153  0.319
2015 Hayashi M, Takai J, Yu L, Motohashi H, Moriguchi T, Yamamoto M. Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice. Molecular and Cellular Biology. 35: 3590-601. PMID 26283726 DOI: 10.1128/Mcb.00506-15  0.315
2015 Cotobal C, Rodríguez-López M, Duncan C, Hasan A, Yamashita A, Yamamoto M, Bähler J, Mata J. Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. Epigenetics & Chromatin. 8: 28. PMID 26279681 DOI: 10.1186/S13072-015-0018-4  0.302
2015 Anand D, Agrawal S, Siddam A, Motohashi H, Yamamoto M, Lachke SA. An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease. Genomics Data. 5: 223-227. PMID 26185746 DOI: 10.1016/J.Gdata.2015.06.017  0.326
2015 Suzuki T, Yamamoto M. Molecular basis of the Keap1-Nrf2 system. Free Radical Biology & Medicine. 88: 93-100. PMID 26117331 DOI: 10.1016/J.Freeradbiomed.2015.06.006  0.319
2015 Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N. Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. Journal of the American Society of Nephrology : Jasn. PMID 26054543 DOI: 10.1681/Asn.2014121184  0.316
2015 Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi SI, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N. Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. Molecular and Cellular Biology. PMID 26012551 DOI: 10.1128/Mcb.00161-15  0.341
2015 Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, Flosseau K, Mandet C, Yamamoto M, Karras A, Thervet E, Bruneval P, Nochy D, Mesnard L, Tharaux PL. Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor γ Essential for Resistance to Crescentic GN. Journal of the American Society of Nephrology : Jasn. PMID 25999406 DOI: 10.1681/Asn.2014111080  0.335
2015 Tsujita T, Baird L, Furusawa Y, Katsuoka F, Hou Y, Gotoh S, Kawaguchi SI, Yamamoto M. Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. PMID 25940588 DOI: 10.1111/Gtc.12248  0.358
2015 Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, Yamamoto M. Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. The Journal of Biological Chemistry. 290: 10644. PMID 25911691 DOI: 10.1074/Jbc.A115.706863  0.327
2015 Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA. Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract. Human Genetics. 134: 717-35. PMID 25896808 DOI: 10.1007/S00439-015-1554-5  0.361
2015 Suzuki N, Mukai HY, Yamamoto M. In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. Plos One. 10: e0119442. PMID 25790231 DOI: 10.1371/Journal.Pone.0119442  0.33
2015 Goto M, Kitamura H, Alam MM, Ota N, Haseba T, Akimoto T, Shimizu A, Takano-Yamamoto T, Yamamoto M, Motohashi H. Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 20: 464-80. PMID 25777368 DOI: 10.1111/Gtc.12237  0.315
2015 Moriguchi T, Yu L, Takai J, Hayashi M, Satoh H, Suzuki M, Ohneda K, Yamamoto M. The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. Molecular and Cellular Biology. 35: 1825-37. PMID 25755285 DOI: 10.1128/Mcb.00011-15  0.358
2015 Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, Yamamoto M. Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression. Molecular and Cellular Biology. 35: 805-15. PMID 25535330 DOI: 10.1128/Mcb.01011-14  0.355
2015 Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ. Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 93-9. PMID 25349122 DOI: 10.1124/Dmd.114.060103  0.343
2015 Kanamori M, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, et al. Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. Neuro-Oncology. 17: 555-65. PMID 25304134 DOI: 10.1093/Neuonc/Nou282  0.337
2015 Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, Imaizumi M, Yamamoto M. Keap1-Nrf2 System: Potential Role in Prevention of Sickle Cell Disease Organs Damages and Inflammation Blood. 126: 411-411. DOI: 10.1182/Blood.V126.23.411.411  0.346
2015 Shohei M, Yamamoto M, Motohashi H. A Stress-Responsive Transcriptional Factor NRF2 Activates Hematopoietic Stem Cells Blood. 126: 2351-2351. DOI: 10.1182/Blood.V126.23.2351.2351  0.351
2014 Furusawa Y, Uruno A, Yagishita Y, Higashi C, Yamamoto M. Nrf2 induces fibroblast growth factor 21 in diabetic mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 19: 864-78. PMID 25270507 DOI: 10.1111/Gtc.12186  0.324
2014 Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, Hayes JD. Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes. Molecular and Cellular Biology. 34: 3800-16. PMID 25092871 DOI: 10.1128/Mcb.00110-14  0.352
2014 Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. The Journal of Biological Chemistry. 289: 24944-55. PMID 25049227 DOI: 10.1074/Jbc.M114.580357  0.324
2014 Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, Yamamoto M. Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 19: 650-65. PMID 25041126 DOI: 10.1111/Gtc.12165  0.317
2014 Togashi N, Yamashita A, Sato M, Yamamoto M. Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast. Bmc Microbiology. 14: 188. PMID 25023750 DOI: 10.1186/1471-2180-14-188  0.331
2014 Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 112-9. PMID 24924401 DOI: 10.1093/Toxsci/Kfu109  0.368
2014 Shichino Y, Yamashita A, Yamamoto M. Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1. Open Biology. 4: 140022. PMID 24920274 DOI: 10.1098/Rsob.140022  0.318
2014 Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, Yamamoto M. Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis. Cancer Prevention Research (Philadelphia, Pa.). 7: 835-44. PMID 24866179 DOI: 10.1158/1940-6207.Capr-14-0094  0.363
2014 Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, Sanyal AJ. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death and Differentiation. 21: 1303-12. PMID 24769730 DOI: 10.1038/Cdd.2014.49  0.365
2014 Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J. Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity. Stem Cells (Dayton, Ohio). 32: 1904-16. PMID 24753106 DOI: 10.1002/Stem.1666  0.341
2014 Wang W, Li S, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, Cui T. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. Journal of Molecular and Cellular Cardiology. 72: 305-15. PMID 24747945 DOI: 10.1016/J.Yjmcc.2014.04.006  0.339
2014 Otsubo Y, Yamashita A, Ohno H, Yamamoto M. S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase. Journal of Cell Science. 127: 2639-46. PMID 24741065 DOI: 10.1242/Jcs.135517  0.307
2014 Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, ... ... Yamamoto M, et al. A promoter-level mammalian expression atlas. Nature. 507: 462-70. PMID 24670764 DOI: 10.1038/Nature13182  0.397
2014 Cui S, Tanabe O, Lim KC, Xu HE, Zhou XE, Lin JD, Shi L, Schmidt L, Campbell A, Shimizu R, Yamamoto M, Engel JD. PGC-1 coactivator activity is required for murine erythropoiesis. Molecular and Cellular Biology. 34: 1956-65. PMID 24662048 DOI: 10.1128/Mcb.00247-14  0.419
2014 Moriguchi T, Yamamoto M. A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation. International Journal of Hematology. 100: 417-24. PMID 24638828 DOI: 10.1007/S12185-014-1568-0  0.374
2014 Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes & Development. 28: 548-60. PMID 24637114 DOI: 10.1101/Gad.237081.113  0.335
2014 Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, Yamamoto M. GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. Molecular and Cellular Biology. 34: 1929-41. PMID 24636993 DOI: 10.1128/Mcb.01659-13  0.336
2014 Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Molecular and Cellular Biology. 34: 1812-26. PMID 24615013 DOI: 10.1128/Mcb.01524-13  0.392
2014 Murakami S, Shimizu R, Romeo PH, Yamamoto M, Motohashi H. Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 19: 239-53. PMID 24580727 DOI: 10.1111/Gtc.12126  0.43
2014 Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T. Keap1 inhibition attenuates glomerulosclerosis. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 29: 783-91. PMID 24523358 DOI: 10.1093/Ndt/Gfu002  0.359
2014 Arata M, Sato M, Yamashita A, Yamamoto M. The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 19: 225-38. PMID 24506453 DOI: 10.1111/Gtc.12133  0.323
2014 Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, Numazawa S. Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5. Redox Biology. 2: 284-8. PMID 24494203 DOI: 10.1016/J.Redox.2013.12.025  0.403
2014 Shirasaki K, Taguchi K, Unno M, Motohashi H, Yamamoto M. NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice. Hepatology (Baltimore, Md.). 59: 2371-82. PMID 24443206 DOI: 10.1002/Hep.27020  0.36
2014 Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. Molecular and Cellular Biology. 34: 900-13. PMID 24379438 DOI: 10.1128/Mcb.01384-13  0.392
2014 Yageta Y, Ishii Y, Morishima Y, Ano S, Ohtsuka S, Matsuyama M, Takeuchi K, Itoh K, Yamamoto M, Hizawa N. Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke. American Journal of Respiratory Cell and Molecular Biology. 50: 963-73. PMID 24303786 DOI: 10.1165/Rcmb.2012-0292Oc  0.33
2014 Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW. Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling. Molecular and Cellular Biology. 34: 653-63. PMID 24298019 DOI: 10.1128/Mcb.01408-13  0.384
2014 Murakami S, Yamamoto M, Motohashi H. Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin 14 promoter. Toxicological Sciences : An Official Journal of the Society of Toxicology. 138: 47-58. PMID 24287212 DOI: 10.1093/Toxsci/Kft273  0.312
2014 Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 63: 605-18. PMID 24186865 DOI: 10.2337/Db13-0909  0.338
2014 Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X. Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut. 63: 711-9. PMID 23676441 DOI: 10.1136/Gutjnl-2012-303731  0.402
2013 Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S. Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Reports. 5: 926-32. PMID 24239357 DOI: 10.1016/J.Celrep.2013.10.021  0.357
2013 Shimizu R, Hasegawa A, Ottolenghi S, Ronchi A, Yamamoto M. Verification of the in vivo activity of three distinct cis-acting elements within the Gata1 gene promoter-proximal enhancer in mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 18: 1032-41. PMID 24118212 DOI: 10.1111/Gtc.12096  0.366
2013 Takai J, Moriguchi T, Suzuki M, Yu L, Ohneda K, Yamamoto M. The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs. Blood. 122: 3450-60. PMID 24021675 DOI: 10.1182/Blood-2013-01-476911  0.371
2013 Yamashita A, Takayama T, Iwata R, Yamamoto M. A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts Nucleic Acids Research. 41: 9680-9687. PMID 23980030 DOI: 10.1093/Nar/Gkt763  0.391
2013 Holmström KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY. Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biology Open. 2: 761-70. PMID 23951401 DOI: 10.1242/Bio.20134853  0.32
2013 Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, ... Yamamoto M, et al. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. Plos One. 8: e69415. PMID 23936010 DOI: 10.1371/Journal.Pone.0069415  0.366
2013 Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 18: 921-33. PMID 23911012 DOI: 10.1111/Gtc.12086  0.375
2013 Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M. Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 18: 886-98. PMID 23890289 DOI: 10.1111/Gtc.12084  0.338
2013 Muramatsu H, Katsuoka F, Toide K, Shimizu Y, Furusako S, Yamamoto M. Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 18: 899-908. PMID 23890231 DOI: 10.1111/Gtc.12083  0.357
2013 Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. Journal of Hepatology. 59: 1200-7. PMID 23867319 DOI: 10.1016/J.Jhep.2013.07.016  0.337
2013 Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M. Plasticity of renal erythropoietin-producing cells governs fibrosis. Journal of the American Society of Nephrology : Jasn. 24: 1599-616. PMID 23833259 DOI: 10.1681/Asn.2013010030  0.313
2013 Kobayashi E, Suzuki T, Yamamoto M. Roles nrf2 plays in myeloid cells and related disorders. Oxidative Medicine and Cellular Longevity. 2013: 529219-529219. PMID 23819012 DOI: 10.1155/2013/529219  0.423
2013 Nakase Y, Nakase M, Kashiwazaki J, Murai T, Otsubo Y, Mabuchi I, Yamamoto M, Takegawa K, Matsumoto T. The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters. Journal of Cell Science. 126: 3972-81. PMID 23813957 DOI: 10.1242/Jcs.128355  0.324
2013 Cho HY, Gladwell W, Yamamoto M, Kleeberger SR. Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2. Oxidative Medicine and Cellular Longevity. 2013: 254069. PMID 23766849 DOI: 10.1155/2013/254069  0.335
2013 Yamashita A, Fujita Y, Yamamoto M. Proper Microtubule Structure Is Vital for Timely Progression through Meiosis in Fission Yeast Plos One. 8. PMID 23755176 DOI: 10.1371/Journal.Pone.0065082  0.318
2013 Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M. Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. The Journal of Biological Chemistry. 288: 20658-67. PMID 23737527 DOI: 10.1074/Jbc.M113.450478  0.329
2013 Himori N, Yamamoto K, Maruyama K, Ryu M, Taguchi K, Yamamoto M, Nakazawa T. Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death. Journal of Neurochemistry. 127: 669-680. PMID 23721546 DOI: 10.1111/Jnc.12325  0.389
2013 Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Molecular and Cellular Biology. 33: 2996-3010. PMID 23716596 DOI: 10.1128/Mcb.00225-13  0.321
2013 Suzuki T, Motohashi H, Yamamoto M. Toward clinical application of the Keap1–Nrf2 pathway Trends in Pharmacological Sciences. 34: 340-346. PMID 23664668 DOI: 10.1016/J.Tips.2013.04.005  0.339
2013 Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M, Motohashi H. NF-E2 p45 is important for establishing normal function of platelets. Molecular and Cellular Biology. 33: 2659-70. PMID 23648484 DOI: 10.1128/Mcb.01274-12  0.32
2013 Aoi Y, Arai K, Miyamoto M, Katsuta Y, Yamashita A, Sato M, Yamamoto M. Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle Embo Reports. 14: 553-560. PMID 23628763 DOI: 10.1038/Embor.2013.52  0.327
2013 Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M. Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis Cancer Research. 73: 4158-4168. PMID 23610445 DOI: 10.1158/0008-5472.Can-12-4499  0.305
2013 Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T. The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. American Journal of Respiratory Cell and Molecular Biology. 49: 324-33. PMID 23590302 DOI: 10.1165/Rcmb.2011-0396Oc  0.354
2013 Hayashi R, Himori N, Taguchi K, Ishikawa Y, Uesugi K, Ito M, Duncan T, Tsujikawa M, Nakazawa T, Yamamoto M, Nishida K. The role of the Nrf2-mediated defense system in corneal epithelial wound healing. Free Radical Biology & Medicine. 61: 333-42. PMID 23587556 DOI: 10.1016/J.Freeradbiomed.2013.04.008  0.349
2013 Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furut K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M. Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels Molecular and Cellular Biology. 33: 2402-2412. PMID 23572560 DOI: 10.1128/Mcb.00065-13  0.402
2013 More VR, Xu J, Shimpi PC, Belgrave C, Luyendyk JP, Yamamoto M, Slitt AL. Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radical Biology & Medicine. 61: 85-94. PMID 23507082 DOI: 10.1016/J.Freeradbiomed.2013.03.007  0.365
2013 Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, et al. Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome. Blood. 121: 3181-4. PMID 23440243 DOI: 10.1182/Blood-2012-01-405746  0.337
2013 Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe O, Engel JD, Yamamoto M. Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. Molecular and Cellular Biology. 33: 1687-95. PMID 23428869 DOI: 10.1128/Mcb.01617-12  0.358
2013 Ashino T, Yamamoto M, Yoshida T, Numazawa S. Redox-Sensitive Transcription Factor Nrf2 Regulates Vascular Smooth Muscle Cell Migration and Neointimal Hyperplasia Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 760-768. PMID 23413426 DOI: 10.1161/Atvbaha.112.300614  0.31
2013 Ruotsalainen A, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen A. The absence of macrophage Nrf2 promotes early atherogenesis. Cardiovascular Research. 98: 107-115. PMID 23341579 DOI: 10.1093/Cvr/Cvt008  0.315
2013 Guiu J, Shimizu R, D'Altri T, Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A. Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of Experimental Medicine. 210: 71-84. PMID 23267012 DOI: 10.1084/Jem.20120993  0.384
2013 Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M. Roles of Keap1-Nrf2 System in Upper Aerodigestive Tract Carcinogenesis Cancer Prevention Research. 6: 149-159. PMID 23250896 DOI: 10.1158/1940-6207.Capr-12-0401-T  0.345
2013 Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes. 62: 845-54. PMID 23238296 DOI: 10.2337/Db12-0584  0.374
2013 Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J. Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet. Journal of Gastroenterology. 48: 620-32. PMID 22972520 DOI: 10.1007/S00535-012-0659-Z  0.36
2013 Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/Ars.2011.4491  0.363
2013 Yamamoto M, Tojo A. Long-Term Ex Vivo Maintenance Of Murine iPSC-Derived Hematopoietic Stem/Progenitor Cells By Conditional HoxB4 Blood. 122: 2418-2418. DOI: 10.1182/Blood.V122.21.2418.2418  0.314
2012 Mitsuishi Y, Motohashi H, Yamamoto M. The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism Frontiers in Oncology. 2: 200-200. PMID 23272301 DOI: 10.3389/Fonc.2012.00200  0.34
2012 Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami K, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K. Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation. Free Radical Biology & Medicine. 53: 2256-62. PMID 23051009 DOI: 10.1016/J.Freeradbiomed.2012.10.001  0.363
2012 Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metabolism. 16: 526-37. PMID 23040073 DOI: 10.1016/J.Cmet.2012.09.007  0.331
2012 Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, Engel JD. Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. The Journal of Clinical Investigation. 122: 3705-17. PMID 22996665 DOI: 10.1172/Jci61619  0.355
2012 Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, Yamamoto M, Ohneda K. Regulation of GATA factor expression is distinct between erythroid and mast cell lineages. Molecular and Cellular Biology. 32: 4742-55. PMID 22988301 DOI: 10.1128/Mcb.00718-12  0.4
2012 Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M. Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. Neurobiology of Disease. 48: 556-67. PMID 22967911 DOI: 10.1016/J.Nbd.2012.07.025  0.354
2012 Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M. Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Research. 40: 10228-39. PMID 22965115 DOI: 10.1093/Nar/Gks827  0.365
2012 Mukaigasa K, Nguyen LT, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Molecular and Cellular Biology. 32: 4455-61. PMID 22949501 DOI: 10.1128/Mcb.00481-12  0.352
2012 Shimizu R, Yamamoto M. Contribution of GATA1 dysfunction to multi-step leukemogenesis. Cancer Science. 103: 2039-2044. PMID 22937757 DOI: 10.1111/Cas.12007  0.382
2012 Otsubo Y, Yamamoto M. Signaling pathways for fission yeast sexual differentiation at a glance Journal of Cell Science. 125: 2789-2793. PMID 22879382 DOI: 10.1242/Jcs.094771  0.32
2012 Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 13561-6. PMID 22872865 DOI: 10.1073/Pnas.1121572109  0.358
2012 Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J. Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 132-44. PMID 22859313 DOI: 10.1093/Toxsci/Kfs237  0.377
2012 Abdullah A, Kitteringham NR, Jenkins RE, Goldring C, Higgins L, Yamamoto M, Hayes J, Park BK. Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. Pharmacological Reports : Pr. 64: 680-97. PMID 22814021 DOI: 10.1016/S1734-1140(12)70863-0  0.4
2012 Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H. Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming Cancer Cell. 22: 66-79. PMID 22789539 DOI: 10.1016/J.Ccr.2012.05.016  0.306
2012 Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Free Radical Biology and Medicine. 53: 817-827. PMID 22732183 DOI: 10.1016/J.Freeradbiomed.2012.06.023  0.341
2012 Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy. Cancer Prevention Research (Philadelphia, Pa.). 5: 973-81. PMID 22659146 DOI: 10.1158/1940-6207.Capr-12-0041  0.32
2012 Yamashita A, Shichino Y, Tanaka H, Hiriart E, Touat-Todeschini L, Vavasseur A, Ding DQ, Hiraoka Y, Verdel A, Yamamoto M. Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes. Open Biology. 2: 120014. PMID 22645662 DOI: 10.1098/Rsob.120014  0.334
2012 Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M. NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1β Genes Molecular and Cellular Biology. 32: 2760-2770. PMID 22586274 DOI: 10.1128/Mcb.06706-11  0.385
2012 Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X. Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus Plos One. 7. PMID 22567161 DOI: 10.1371/Journal.Pone.0036504  0.377
2012 Kaneko H, Kobayashi E, Yamamoto M, Shimizu R. N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. The Journal of Biological Chemistry. 287: 21439-49. PMID 22556427 DOI: 10.1074/Jbc.M112.370437  0.354
2012 Hiriart E, Vavasseur A, Touat-Todeschini L, Yamashita A, Gilquin B, Lambert E, Perot J, Shichino Y, Nazaret N, Boyault C, Lachuer J, Perazza D, Yamamoto M, Verdel A. Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast. The Embo Journal. 31: 2296-308. PMID 22522705 DOI: 10.1038/Emboj.2012.105  0.316
2012 Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M. UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. Molecular and Cellular Biology. 32: 2312-22. PMID 22493062 DOI: 10.1128/Mcb.06699-11  0.385
2012 Cho HY, van Houten B, Wang X, Miller-DeGraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, Kleeberger SR. Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxidants & Redox Signaling. 17: 1066-82. PMID 22400915 DOI: 10.1089/Ars.2011.4288  0.323
2012 Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radical Biology & Medicine. 52: 1708-15. PMID 22370093 DOI: 10.1016/J.Freeradbiomed.2012.02.022  0.374
2012 Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis Journal of Gastroenterology. 47: 924-935. PMID 22367278 DOI: 10.1007/S00535-012-0552-9  0.327
2012 Hasegawa A, Shimizu R, Mohandas N, Yamamoto M. Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction. Blood. 119: 2615-23. PMID 22279059 DOI: 10.1182/Blood-2011-09-382473  0.378
2012 Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. The Journal of Pharmacology and Experimental Therapeutics. 341: 274-84. PMID 22267202 DOI: 10.1124/Jpet.111.190132  0.369
2012 Xue M, Rabbani N, Momiji H, Imbasi P, Anwar MM, Kitteringham N, Park BK, Souma T, Moriguchi T, Yamamoto M, Thornalley PJ. Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation Biochemical Journal. 443: 213-222. PMID 22188542 DOI: 10.1042/Bj20111648  0.336
2012 Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M. Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins. Molecular and Cellular Biology. 32: 808-16. PMID 22158967 DOI: 10.1128/Mcb.06543-11  0.368
2012 Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J. Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radical Biology & Medicine. 52: 462-72. PMID 22138520 DOI: 10.1016/J.Freeradbiomed.2011.10.453  0.423
2012 Bista P, Zeng W, Ryan S, Lukashev M, Yamamoto M. Dimethyl Fumarate Suppresses Inflammation In Vitro Via Both Nrf2-Dependent and Nrf2-Independent Pathways (P02.108) Neurology. 78. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P02.108  0.323
2011 Sukegawa Y, Yamashita A, Yamamoto M. The fission yeast Stress-Responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues Plos Genetics. 7. PMID 22144909 DOI: 10.1371/Journal.Pgen.1002387  0.338
2011 Nakajima H, Nakajima-Takagi Y, Tsujita T, Akiyama S, Wakasa T, Mukaigasa K, Kaneko H, Tamaru Y, Yamamoto M, Kobayashi M. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Plos One. 6: e26884. PMID 22046393 DOI: 10.1371/Journal.Pone.0026884  0.357
2011 Bauer AK, Cho HY, Miller-Degraff L, Walker C, Helms K, Fostel J, Yamamoto M, Kleeberger SR. Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. Plos One. 6: e26590. PMID 22039513 DOI: 10.1371/Journal.Pone.0026590  0.392
2011 Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, Yamamoto M. Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. Plos One. 6: e25839. PMID 22022454 DOI: 10.1371/Journal.Pone.0025839  0.373
2011 Hoshino T, Tabuchi K, Nishimura B, Tanaka S, Nakayama M, Ishii T, Warabi E, Yanagawa T, Shimizu R, Yamamoto M, Hara A. Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity Biochemical and Biophysical Research Communications. 415: 94-98. PMID 22020098 DOI: 10.1016/J.Bbrc.2011.10.019  0.354
2011 Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A. Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Molecular and Cellular Biology. 31: 4500-12. PMID 21911472 DOI: 10.1128/Mcb.05663-11  0.362
2011 Wong TF, Yoshinaga K, Monma Y, Ito K, Niikura H, Nagase S, Yamamoto M, Yaegashi N. Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 21: 1428-35. PMID 21897267 DOI: 10.1097/Igc.0B013E31822D0Eb2  0.318
2011 Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, Yamamoto M. Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages. Molecular and Cellular Biology. 31: 3896-905. PMID 21746884 DOI: 10.1128/Mcb.05463-11  0.351
2011 Mimura J, Kosaka K, Maruyama A, Satoh T, Harada N, Yoshida H, Satoh K, Yamamoto M, Itoh K. Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes. Journal of Biochemistry. 150: 209-17. PMID 21596795 DOI: 10.1093/Jb/Mvr065  0.34
2011 Hirota A, Kawachi Y, Yamamoto M, Koga T, Hamada K, Otsuka F. Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice. Experimental Dermatology. 20: 664-8. PMID 21569103 DOI: 10.1111/J.1600-0625.2011.01292.X  0.384
2011 Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M. Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 16: 692-703. PMID 21554501 DOI: 10.1111/J.1365-2443.2011.01522.X  0.392
2011 Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL. Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1. Journal of Biochemical and Molecular Toxicology. 25: 320-9. PMID 21538727 DOI: 10.1002/Jbt.20392  0.332
2011 Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF, Kopf M. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. European Journal of Immunology. 41: 2040-2051. PMID 21484785 DOI: 10.1002/Eji.201041316  0.311
2011 Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. The Journal of Cell Biology. 193: 275-84. PMID 21482715 DOI: 10.1083/Jcb.201102031  0.349
2011 Kakui Y, Sato M, Tanaka K, Yamamoto M. A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division Yeast. 28: 467-479. PMID 21449049 DOI: 10.1002/Yea.1851  0.306
2011 Watanabe-Matsui M, Muto A, Matsui T, Itoh-Nakadai A, Nakajima O, Murayama K, Yamamoto M, Ikeda-Saito M, Igarashi K. Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2. Blood. 117: 5438-48. PMID 21444915 DOI: 10.1182/Blood-2010-07-296483  0.347
2011 Hirotsu Y, Katsuoka F, Itoh K, Yamamoto M. Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers. Genes to Cells. 16: 406-415. PMID 21392184 DOI: 10.1111/J.1365-2443.2011.01496.X  0.365
2011 Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y. Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone. Chemical Research in Toxicology. 24: 559-67. PMID 21384861 DOI: 10.1021/Tx100427P  0.389
2011 Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y. Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. Environmental Health Perspectives. 119: 1117-1122. PMID 21382770 DOI: 10.1289/Ehp.1003123  0.375
2011 Kuhn AM, Tzieply N, Schmidt MV, von Knethen A, Namgaladze D, Yamamoto M, Brüne B. Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages. Free Radical Biology & Medicine. 50: 1382-91. PMID 21382476 DOI: 10.1016/J.Freeradbiomed.2011.02.036  0.354
2011 Kansanen E, Bonacci G, Schopfer FJ, Kuosmanen SM, Tong KI, Leinonen H, Woodcock SR, Yamamoto M, Carlberg C, Ylä-Herttuala S, Freeman BA, Levonen AL. Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism. The Journal of Biological Chemistry. 286: 14019-27. PMID 21357422 DOI: 10.1074/Jbc.M110.190710  0.336
2011 Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Research in Cardiology. 106: 343-54. PMID 21347618 DOI: 10.1007/S00395-011-0158-Z  0.314
2011 Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nature Communications. 2: 181. PMID 21304510 DOI: 10.1038/Ncomms1182  0.36
2011 Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, Mimura J, Toki T, Maher JM, Yamamoto M, Itoh K. Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages. Archives of Biochemistry and Biophysics. 508: 101-9. PMID 21303654 DOI: 10.1016/J.Abb.2011.02.001  0.314
2011 Suzuki M, Shimizu R, Yamamoto M. Transcriptional regulation by GATA1 and GATA2 during erythropoiesis. International Journal of Hematology. 93: 150-5. PMID 21279818 DOI: 10.1007/S12185-011-0770-6  0.375
2011 Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes to Cells. 16: 123-140. PMID 21251164 DOI: 10.1111/J.1365-2443.2010.01473.X  0.379
2011 Li J, Zhang C, Xing Y, Janicki JS, Yamamoto M, Wang XL, Tang DQ, Cui T. Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy. Cardiovascular Research. 90: 315-24. PMID 21245055 DOI: 10.1093/Cvr/Cvr010  0.321
2011 You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Archives of Biochemistry and Biophysics. 507: 356-64. PMID 21211512 DOI: 10.1016/J.Abb.2010.12.034  0.406
2011 Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M. Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. Biochemical and Biophysical Research Communications. 405: 13-8. PMID 21185264 DOI: 10.1016/J.Bbrc.2010.12.092  0.336
2011 Suzuki T, Maher J, Yamamoto M. Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo. Cancer Research. 71: 1700-9. PMID 21177379 DOI: 10.1158/0008-5472.Can-10-2939  0.344
2011 Tsujita T, Li L, Nakajima H, Iwamoto N, Nakajima-Takagi Y, Ohashi K, Kawakami K, Kumagai Y, Freeman BA, Yamamoto M, Kobayashi M. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: A study using green fluorescent protein transgenic zebrafish Genes to Cells. 16: 46-57. PMID 21143560 DOI: 10.1111/J.1365-2443.2010.01466.X  0.32
2011 Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M. Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. Blood. 117: 986-96. PMID 20978266 DOI: 10.1182/Blood-2010-05-285817  0.414
2011 Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M. Molecular determinants for small Maf protein control of platelet production. Molecular and Cellular Biology. 31: 151-62. PMID 20974807 DOI: 10.1128/Mcb.00798-10  0.37
2011 Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, Hatsuno M, Yamamoto M, Yoshida T. Possible involvement of oxidative stress in 5-fluorouracil-mediated myelosuppression in mice. Basic & Clinical Pharmacology & Toxicology. 108: 40-45. PMID 20722640 DOI: 10.1111/J.1742-7843.2010.00621.X  0.337
2011 Kaneko H, Kobayashi E, Shimizu R, Yamamoto M. Two Distinct Transactivation Domains of GATA1 Contribute Megakaryopoiesis, Blood. 118: 3384-3384. DOI: 10.1182/Blood.V118.21.3384.3384  0.32
2011 Toki T, Kobayashi E, Kanezaki R, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Shimizu R, Yamamoto M, Ito E. GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome Blood. 118: 1491-1491. DOI: 10.1182/Blood.V118.21.1491.1491  0.331
2011 Kokubo T, Taniguchi Y, Kanayama M, Shimura M, Konishi Y, Kawagishi H, Yamamoto M, Shindo K, Yoshida A. Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2 Food Chemistry. 129: 92-99. DOI: 10.1016/J.Foodchem.2011.04.031  0.358
2010 Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S. Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway. Cancer Research. 70: 9095-105. PMID 21062981 DOI: 10.1158/0008-5472.Can-10-0384  0.389
2010 Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. The Journal of Cell Biology. 191: 537-52. PMID 21041446 DOI: 10.1083/Jcb.201005012  0.349
2010 Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL. CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. The Journal of Clinical Investigation. 120: 3996-4006. PMID 20978343 DOI: 10.1172/Jci42823  0.309
2010 Arai K, Sato M, Tanaka K, Yamamoto M. Nuclear compartmentalization is abolished during fission yeast meiosis Current Biology. 20: 1913-1918. PMID 20970334 DOI: 10.1016/J.Cub.2010.09.004  0.307
2010 Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE. Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene. Bmc Cancer. 10: 540. PMID 20932318 DOI: 10.1186/1471-2407-10-540  0.393
2010 Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I. Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clinical Immunology (Orlando, Fla.). 137: 234-41. PMID 20797910 DOI: 10.1016/J.Clim.2010.07.014  0.336
2010 Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y. Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes. Biochemistry. 49: 8053-61. PMID 20718447 DOI: 10.1021/Bi100545H  0.333
2010 Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science Signaling. 3: ra52. PMID 20628156 DOI: 10.1126/Scisignal.2000762  0.374
2010 Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT, Raman V, Ebina M, Nukiwa T, Yamamoto M. Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. Carcinogenesis. 31: 1833-43. PMID 20513672 DOI: 10.1093/Carcin/Bgq105  0.354
2010 Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T. The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response Journal of Biological Chemistry. 285: 23970-23984. PMID 20498371 DOI: 10.1074/Jbc.M110.145441  0.343
2010 Scheerer N, Dünker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J. The anemia of the newborn induces erythropoietin expression in the developing mouse retina American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 299. PMID 20463184 DOI: 10.1152/Ajpregu.00108.2010  0.327
2010 Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G. Ablation of the Transcription Factor Nrf2 Promotes Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1553-1561. PMID 20448209 DOI: 10.1161/Atvbaha.110.204123  0.384
2010 Itoh K, Mimura J, Yamamoto M. Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxidants & Redox Signaling. 13: 1665-1678. PMID 20446768 DOI: 10.1089/Ars.2010.3222  0.379
2010 Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Doré S. The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1951-61. PMID 20442725 DOI: 10.1038/Jcbfm.2010.53  0.315
2010 Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M. Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Molecular and Cellular Biology. 30: 3016-26. PMID 20404090 DOI: 10.1128/Mcb.01591-09  0.365
2010 Lämsä V, Levonen AL, Leinonen H, Ylä-Herttuala S, Yamamoto M, Hakkola J. Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver. Chemical Research in Toxicology. 23: 977-85. PMID 20402460 DOI: 10.1021/Tx100084C  0.407
2010 Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. Journal of Proteomics. 73: 1612-31. PMID 20399915 DOI: 10.1016/J.Jprot.2010.03.018  0.389
2010 Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M. Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis. Molecular and Cellular Biology. 30: 2668-80. PMID 20351175 DOI: 10.1128/Mcb.01304-09  0.41
2010 Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itoh K, Yamamoto M, Hizawa N. Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance. Respiratory Research. 11: 31. PMID 20298567 DOI: 10.1186/1465-9921-11-31  0.335
2010 Kaneko H, Shimizu R, Yamamoto M. GATA factor switching during erythroid differentiation. Current Opinion in Hematology. 17: 163-8. PMID 20216212 DOI: 10.1097/Moh.0B013E32833800B8  0.392
2010 Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G. Increased Susceptibility of Nrf2-Null Mice to 1-Bromopropane–Induced Hepatotoxicity Toxicological Sciences. 115: 596-606. PMID 20211940 DOI: 10.1093/Toxsci/Kfq075  0.351
2010 Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, ... ... Yamamoto M, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nature Cell Biology. 12: 213-23. PMID 20173742 DOI: 10.1038/Ncb2021  0.362
2010 Kim K, Suzuki N, Ohneda K, Minegishi N, Yamamoto M. Fractionation of mature eosinophils in GATA-reporter transgenic mice. The Tohoku Journal of Experimental Medicine. 220: 127-38. PMID 20139664 DOI: 10.1620/Tjem.220.127  0.362
2010 Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 2842-7. PMID 20133743 DOI: 10.1073/Pnas.0914036107  0.31
2010 Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T. The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 238-52. PMID 20133372 DOI: 10.1093/Toxsci/Kfq039  0.378
2010 Maher J, Yamamoto M. The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2. Toxicology and Applied Pharmacology. 244: 4-15. PMID 20122947 DOI: 10.1016/J.Taap.2010.01.011  0.376
2010 Takeuchi M, Kaneko H, Nishikawa K, Kawakami K, Yamamoto M, Kobayashi M. Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis. Development, Growth & Differentiation. 52: 245-50. PMID 20100247 DOI: 10.1111/J.1440-169X.2009.01168.X  0.325
2010 Pi J, Freeman ML, Yamamoto M. Nrf2 in toxicology and pharmacology: the good, the bad and the ugly? Toxicology and Applied Pharmacology. 244: 1-3. PMID 20079756 DOI: 10.1016/J.Taap.2010.01.005  0.324
2010 Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, Yamamoto M, Reddy SP, Lutty GA. Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy. Experimental Eye Research. 90: 493-500. PMID 20064509 DOI: 10.1016/J.Exer.2009.12.012  0.336
2010 Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M. A novel type of E3 ligase for the Ufm1 conjugation system. The Journal of Biological Chemistry. 285: 5417-27. PMID 20018847 DOI: 10.1074/Jbc.M109.036814  0.31
2010 Okano S, Zhou L, Kusaka T, Shibata K, Shimizu K, Gao X, Kikuchi Y, Togashi Y, Hosoya T, Takahashi S, Nakajima O, Yamamoto M. Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 15: 77-89. PMID 20015225 DOI: 10.1111/J.1365-2443.2009.01366.X  0.344
2010 Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 298: G283-94. PMID 19926817 DOI: 10.1152/Ajpgi.00296.2009  0.348
2010 Rojo AI, Innamorato NG, Martín-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A. Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Glia. 58: 588-98. PMID 19908287 DOI: 10.1002/Glia.20947  0.358
2010 Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M. NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. Blood. 115: 677-86. PMID 19901266 DOI: 10.1182/Blood-2009-05-223107  0.368
2010 Iida K, Mimura J, Itoh K, Ohyama C, Fujii-Kuriyama Y, Shimazui T, Akaza H, Yamamoto M. Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice Journal of Biochemistry. 147: 353-360. PMID 19880377 DOI: 10.1093/Jb/Mvp169  0.368
2010 Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M. Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of a GATA1 Protein Lacking the N-terminal Domain Journal of Biological Chemistry. 285: 773-783. PMID 19854837 DOI: 10.1074/Jbc.M109.030726  0.415
2010 Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E. NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 39-48. PMID 19720622 DOI: 10.1096/Fj.09-133520  0.367
2010 Pan X, Suzuki N, Hirano I, Yamazaki S, Yamashita T, Ohneda O, Minegishi N, Yamamoto M. Isolation and Characterization of Renal Erythropoietin-Producing Cells: Contribution of HIF3α In Vivo. Blood. 116: 1541-1541. DOI: 10.1182/Blood.V116.21.1541.1541  0.33
2009 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 4601-8. PMID 19734219 DOI: 10.4049/Jimmunol.0901754  0.36
2009 Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M. Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. Biochemical and Biophysical Research Communications. 389: 431-6. PMID 19732748 DOI: 10.1016/J.Bbrc.2009.08.156  0.339
2009 Ohneda K, Ohmori S, Ishijima Y, Nakano M, Yamamoto M. Characterization of a Functional ZBP-89 Binding Site That Mediates Gata1 Gene Expression during Hematopoietic Development Journal of Biological Chemistry. 284: 30187-30199. PMID 19723625 DOI: 10.1074/Jbc.M109.026948  0.384
2009 Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European Journal of Pharmacology. 620: 138-44. PMID 19698707 DOI: 10.1016/J.Ejphar.2009.08.022  0.333
2009 Sato M, Okada N, Kakui Y, Yamamoto M, Yoshida M, Toda T. Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast Embo Reports. 10: 1161-1167. PMID 19696784 DOI: 10.1038/Embor.2009.158  0.301
2009 Shimizu R, Kobayashi E, Engel JD, Yamamoto M. Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 1119-31. PMID 19682090 DOI: 10.1111/J.1365-2443.2009.01338.X  0.354
2009 Funatake CJ, Ao K, Suzuki T, Murai H, Yamamoto M, Fujii-Kuriyama Y, Kerkvliet NI, Nohara K. Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response. Journal of Immunotoxicology. 6: 194-203. PMID 19635034 DOI: 10.1080/15476910903124454  0.322
2009 Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M, Hayes JD. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein. Carcinogenesis. 30: 1754-62. PMID 19633057 DOI: 10.1093/Carcin/Bgp182  0.352
2009 Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Matsui H, Yoshikawa T. Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1. The Journal of Pharmacology and Experimental Therapeutics. 331: 255-64. PMID 19628634 DOI: 10.1124/Jpet.109.152702  0.342
2009 Takeuchi T, Kudo T, Ogata K, Hamada M, Nakamura M, Kito K, Abe Y, Ueda N, Yamamoto M, Engel JD, Takahashi S. Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 941-7. PMID 19624757 DOI: 10.1111/J.1365-2443.2009.01321.X  0.363
2009 Li J, Ichikawa T, Villacorta L, Janicki JS, Brower GL, Yamamoto M, Cui T. Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1843-50. PMID 19592468 DOI: 10.1161/Atvbaha.109.189480  0.316
2009 Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S. Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis Plos Biology. 7. PMID 19513100 DOI: 10.1371/Journal.Pbio.1000123  0.373
2009 Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 7264-71. PMID 19454723 DOI: 10.4049/Jimmunol.0804248  0.354
2009 Liu M, Grigoryev DN, Crow MT, Haas M, Yamamoto M, Reddy SP, Rabb H. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney International. 76: 277-85. PMID 19436334 DOI: 10.1038/Ki.2009.157  0.37
2009 Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3423-32. PMID 19417020 DOI: 10.1158/1078-0432.Ccr-08-2822  0.326
2009 Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 30: 1024-31. PMID 19386581 DOI: 10.1093/Carcin/Bgp100  0.356
2009 Nozawa D, Suzuki N, Kobayashi-Osaki M, Pan X, Engel JD, Yamamoto M. GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 569-82. PMID 19371385 DOI: 10.1111/J.1365-2443.2009.01289.X  0.36
2009 Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, Hayes JD. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents Toxicology and Applied Pharmacology. 237: 267-280. PMID 19303893 DOI: 10.1016/J.Taap.2009.03.005  0.34
2009 Abe K, Shimizu R, Pan X, Hamada H, Yoshikawa H, Yamamoto M. Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment. Experimental Hematology. 37: 435-445.e1. PMID 19302918 DOI: 10.1016/J.Exphem.2008.12.004  0.394
2009 Eguchi-Ishimae M, Eguchi M, Maki K, Porcher C, Shimizu R, Yamamoto M, Mitani K. Leukemia‐related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis Cancer Science. 100: 689-697. PMID 19302286 DOI: 10.1111/J.1349-7006.2009.01097.X  0.393
2009 Satoh T, Harada N, Hosoya T, Tohyama K, Yamamoto M, Itoh K. Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice Biochemical and Biophysical Research Communications. 380: 298-302. PMID 19167360 DOI: 10.1016/J.Bbrc.2009.01.063  0.346
2009 Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE. Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice Toxicology Letters. 185: 180-186. PMID 19150646 DOI: 10.1016/J.Toxlet.2008.12.014  0.356
2009 Reisman SA, Yeager RL, Yamamoto M, Klaassen CD. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 35-47. PMID 19129213 DOI: 10.1093/Toxsci/Kfn267  0.359
2009 Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/Pnas.0804333106  0.364
2009 Suzuki M, Moriguchi T, Ohneda K, Yamamoto M. Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation. Molecular and Cellular Biology. 29: 1163-75. PMID 19103751 DOI: 10.1128/Mcb.01572-08  0.382
2009 Zhang Y, Kobayashi A, Yamamoto M, Hayes JD. The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. The Journal of Biological Chemistry. 284: 3195-210. PMID 19047052 DOI: 10.1074/Jbc.M805337200  0.324
2009 Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radical Biology & Medicine. 46: 376-86. PMID 19027064 DOI: 10.1016/J.Freeradbiomed.2008.10.026  0.359
2009 Charoenchaikorn K, Yokomizo T, Rice DP, Honjo T, Matsuzaki K, Shintaku Y, Imai Y, Wakamatsu A, Takahashi S, Ito Y, Takano-Yamamoto T, Thesleff I, Yamamoto M, Yamashiro T. Runx1 is involved in the fusion of the primary and the secondary palatal shelves. Developmental Biology. 326: 392-402. PMID 19000669 DOI: 10.1016/J.Ydbio.2008.10.018  0.36
2009 Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Polack FP, Kleeberger SR. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. American Journal of Respiratory and Critical Care Medicine. 179: 138-50. PMID 18931336 DOI: 10.1164/Rccm.200804-535Oc  0.344
2009 Shimizu R, Hasegawa A, Yamamoto M. Spherocytic Hemolytic Anemia Caused by Disruption of GATA1-FOG1 Interaction. Blood. 114: 775-775. DOI: 10.1182/Blood.V114.22.775.775  0.367
2009 Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M. Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of GATA1 Protein Lacking the N-Terminal Domain. Blood. 114: 3648-3648. DOI: 10.1182/Blood.V114.22.3648.3648  0.381
2009 Yamazaki S, Suzuki N, Obara N, Pan X, Hirano I, Jishage K, Honda K, Minegishi N, Yamamoto M. Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene. Blood. 114: 3614-3614. DOI: 10.1182/Blood.V114.22.3614.3614  0.361
2009 Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M. Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Lineage Development. Blood. 114: 1993-1993. DOI: 10.1182/Blood.V114.22.1993.1993  0.363
2008 Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, Yamamoto M. Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice Genes to Cells. 13: 1159-1170. PMID 19090810 DOI: 10.1111/J.1365-2443.2008.01234.X  0.346
2008 Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher JM, Matsui H, Hyodo I, Yamamoto M, Hosoya T. Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments. The Tohoku Journal of Experimental Medicine. 216: 331-9. PMID 19060448 DOI: 10.1620/Tjem.216.331  0.38
2008 Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, ... ... Yamamoto M, et al. Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell. 3: 555-67. PMID 18983969 DOI: 10.1016/J.Stem.2008.09.003  0.397
2008 Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. The Journal of Biological Chemistry. 283: 33554-62. PMID 18826952 DOI: 10.1074/Jbc.M804597200  0.427
2008 Hirota K, Sakamaki J, Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K, Fukamizu A. A Combination of HNF-4 and Foxo1 Is Required for Reciprocal Transcriptional Regulation of Glucokinase and Glucose-6-phosphatase Genes in Response to Fasting and Feeding Journal of Biological Chemistry. 283: 32432-32441. PMID 18805788 DOI: 10.1074/Jbc.M806179200  0.363
2008 Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. Journal of Immunology (Baltimore, Md. : 1950). 181: 4545-59. PMID 18802057 DOI: 10.4049/Jimmunol.181.7.4545  0.337
2008 Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Proceedings of the National Academy of Sciences of the United States of America. 105: 13568-13573. PMID 18757741 DOI: 10.1073/Pnas.0806268105  0.381
2008 Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. Molecular and Cellular Neurosciences. 39: 302-13. PMID 18706502 DOI: 10.1016/J.Mcn.2008.07.010  0.34
2008 Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S. Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer Gastroenterology. 135: 1358-1368. PMID 18692501 DOI: 10.1053/J.Gastro.2008.06.082  0.346
2008 Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, ... Yamamoto M, et al. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G735-47. PMID 18687751 DOI: 10.1152/Ajpgi.90321.2008  0.397
2008 Marhenke S, Lamlé J, Buitrago-Molina LE, Cañón JM, Geffers R, Finegold M, Sporn M, Yamamoto M, Manns MP, Grompe M, Vogel A. Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development. Hepatology (Baltimore, Md.). 48: 487-96. PMID 18666252 DOI: 10.1002/Hep.22391  0.353
2008 Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I. Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clinical Immunology (Orlando, Fla.). 128: 366-73. PMID 18614404 DOI: 10.1016/J.Clim.2008.05.005  0.352
2008 Yokomizo T, Yanagida M, Huang G, Osato M, Honda C, Ema M, Takahashi S, Yamamoto M, Ito Y. Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo. International Journal of Hematology. 88: 134-8. PMID 18594778 DOI: 10.1007/S12185-008-0121-4  0.39
2008 Maruyama A, Tsukamoto S, Nishikawa K, Yoshida A, Harada N, Motojima K, Ishii T, Nakane A, Yamamoto M, Itoh K. Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements. Archives of Biochemistry and Biophysics. 477: 139-145. PMID 18585365 DOI: 10.1016/J.Abb.2008.06.004  0.312
2008 Innamorato NG, Rojo AI, García-Yagüe AJ, Yamamoto M, de Ceballos ML, Cuadrado A. The transcription factor Nrf2 is a therapeutic target against brain inflammation. Journal of Immunology (Baltimore, Md. : 1950). 181: 680-9. PMID 18566435 DOI: 10.4049/Jimmunol.181.1.680  0.351
2008 Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, Reddy SP. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene. 27: 5821-32. PMID 18542053 DOI: 10.1038/Onc.2008.188  0.372
2008 Jyrkkänen HK, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, et al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circulation Research. 103: e1-9. PMID 18535259 DOI: 10.1161/Circresaha.108.176883  0.386
2008 Kusano Y, Horie S, Shibata T, Satsu H, Shimizu M, Hitomi E, Nishida M, Kurose H, Itoh K, Kobayashi A, Yamamoto M, Uchida K. Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. Biochemistry. 47: 6169-6177. PMID 18476723 DOI: 10.1021/Bi800199Z  0.365
2008 Zhu H, Jia Z, Misra BR, Zhang L, Cao Z, Yamamoto M, Trush MA, Misra HP, Li Y. Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress. Cardiovascular Toxicology. 8: 71-85. PMID 18463988 DOI: 10.1007/S12012-008-9016-0  0.385
2008 Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 218-27. PMID 18417483 DOI: 10.1093/Toxsci/Kfn079  0.381
2008 Harada H, Sugimoto R, Watanabe A, Taketani S, Okada K, Warabi E, Siow R, Itoh K, Yamamoto M, Ishii T. Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. Free Radical Research. 42: 297-304. PMID 18404528 DOI: 10.1080/10715760801975735  0.396
2008 Zhu H, Jia Z, Zhang L, Yamamoto M, Misra HP, Trush MA, Li Y. Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress. Experimental Biology and Medicine (Maywood, N.J.). 233: 463-74. PMID 18367636 DOI: 10.3181/0711-Rm-304  0.353
2008 Kanki K, Umemura T, Kitamura Y, Ishii Y, Kuroiwa Y, Kodama Y, Itoh K, Yamamoto M, Nishikawa A, Hirose M. A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate. Toxicologic Pathology. 36: 353-361. PMID 18364461 DOI: 10.1177/0192623307311401  0.33
2008 Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S. Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth Cancer Research. 68: 1303-1309. PMID 18316592 DOI: 10.1158/0008-5472.Can-07-5003  0.349
2008 Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology & Medicine. 44: 1645-55. PMID 18294972 DOI: 10.1016/J.Freeradbiomed.2008.01.024  0.326
2008 Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. 105: 2325-30. PMID 18287083 DOI: 10.1073/Pnas.0712162105  0.316
2008 Yamamoto T, Suzuki T, Kobayashi A, Wakabayashi J, Maher J, Motohashi H, Yamamoto M. Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Molecular and Cellular Biology. 28: 2758-2770. PMID 18268004 DOI: 10.1128/Mcb.01704-07  0.41
2008 Gutiérrez L, Tsukamoto S, Suzuki M, Yamamoto-Mukai H, Yamamoto M, Philipsen S, Ohneda K. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood. 111: 4375-85. PMID 18258797 DOI: 10.1182/Blood-2007-09-115121  0.35
2008 Yokomizo T, Hasegawa K, Ishitobi H, Osato M, Ema M, Ito Y, Yamamoto M, Takahashi S. Runx1 is involved in primitive erythropoiesis in the mouse. Blood. 111: 4075-4080. PMID 18250229 DOI: 10.1182/Blood-2007-05-091637  0.404
2008 Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 13: 159-70. PMID 18233958 DOI: 10.1111/J.1365-2443.2007.01158.X  0.373
2008 Brandt W, Khandekar M, Suzuki N, Yamamoto M, Lim KC, Engel JD. Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. The Journal of Biological Chemistry. 283: 8976-83. PMID 18211891 DOI: 10.1074/Jbc.M709364200  0.382
2008 Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 111: 5223-32. PMID 18202227 DOI: 10.1182/Blood-2007-10-115857  0.406
2008 Kawachi Y, Xu X, Taguchi S, Sakurai H, Nakamura Y, Ishii Y, Fujisawa Y, Furuta J, Takahashi T, Itoh K, Yamamoto M, Yamazaki F, Otsuka F. Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice. Journal of Investigative Dermatology. 128: 1773-1779. PMID 18200051 DOI: 10.1038/Sj.Jid.5701245  0.364
2008 Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M. Deletion of the Selenocysteine tRNA Gene in Macrophages and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by Nrf2 Journal of Biological Chemistry. 283: 2021-2030. PMID 18039655 DOI: 10.1074/Jbc.M708352200  0.415
2008 Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein Toxicology and Applied Pharmacology. 226: 328-337. PMID 18028974 DOI: 10.1016/J.Taap.2007.09.018  0.377
2008 Hosoya T, Harada N, Mimura J, Motohashi H, Takahashi S, Nakajima O, Morita M, Kawauchi S, Yamamoto M, Fujii-Kuriyama Y. Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice Biochemical and Biophysical Research Communications. 365: 562-567. PMID 18022386 DOI: 10.1016/J.Bbrc.2007.11.016  0.337
2008 Ashino T, Yamanaka R, Yamamoto M, Shimokawa H, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. Molecular Immunology. 45: 2106-2115. PMID 18022235 DOI: 10.1016/J.Molimm.2007.10.011  0.306
2008 Saito S, Nouno K, Shimizu R, Yamamoto M, Nagata K. Impairment of erythroid and megakaryocytic differentiation by a Leukemia-Associated and t(9;9)-derived fusion gene product, SET/TAF-Iβ-CAN/Nup214† Journal of Cellular Physiology. 214: 322-333. PMID 17620317 DOI: 10.1002/Jcp.21199  0.351
2008 Shimizu R, Kobayashi E, Engel J, Yamamoto M. Induction of Hyperproliferative Fetal Megakaryopoiesis by An N-Terminally Truncated GATA1 Mutant. Blood. 112: 1191-1191. DOI: 10.1182/Blood.V112.11.1191.1191  0.341
2007 Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, ... ... Yamamoto M, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 131: 1149-63. PMID 18083104 DOI: 10.1016/J.Cell.2007.10.035  0.324
2007 Li L, Kobayashi M, Kaneko H, Nakajima-Takagi Y, Nakayama Y, Yamamoto M. Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish. The Journal of Biological Chemistry. 283: 3248-55. PMID 18057000 DOI: 10.1074/Jbc.M708702200  0.389
2007 Suzuki N, Obara N, Yamamoto M. Use of gene-manipulated mice in the study of erythropoietin gene expression. Methods in Enzymology. 435: 157-77. PMID 17998054 DOI: 10.1016/S0076-6879(07)35009-X  0.41
2007 Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development. 21: 2832-44. PMID 17974920 DOI: 10.1101/Gad.1593307  0.389
2007 Jałoszyński P, Murata S, Shinkai Y, Takahashi S, Kumagai Y, Nishimura S, Yamamoto M. Dysfunction of Nrf2 decreases KBrO3-induced oxidative DNA damage in Ogg1-null mice. Biochemical and Biophysical Research Communications. 364: 966-971. PMID 17971305 DOI: 10.1016/J.Bbrc.2007.10.123  0.376
2007 Okitsu Y, Takahashi S, Minegishi N, Kameoka J, Kaku M, Yamamoto M, Sasaki T, Harigae H. Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Biochemical and Biophysical Research Communications. 364: 383-7. PMID 17950250 DOI: 10.1016/J.Bbrc.2007.10.031  0.359
2007 Oshima M, Mimura J, Yamamoto M, Fujii-Kuriyama Y. Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. Biochemical and Biophysical Research Communications. 364: 276-282. PMID 17949687 DOI: 10.1016/J.Bbrc.2007.09.131  0.349
2007 Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Fujii-Kuriyama Y, Ohneda O, Yamamoto M, Strihou CvYd, Hirayama N, Miyata T. A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2548-2554. PMID 17932321 DOI: 10.1161/Atvbaha.107.148551  0.307
2007 Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, Kumagai Y. Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. Biochemical and Biophysical Research Communications. 363: 645-650. PMID 17904103 DOI: 10.1016/J.Bbrc.2007.09.017  0.366
2007 Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M. Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 12: 1163-78. PMID 17903176 DOI: 10.1111/J.1365-2443.2007.01118.X  0.352
2007 Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW, Scollick C, Biswal S, Reddy SP. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiological Genomics. 32: 74-81. PMID 17895394 DOI: 10.1152/Physiolgenomics.00126.2007  0.418
2007 Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga J, Shimano H. In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. Biochemical and Biophysical Research Communications. 363: 329-35. PMID 17880923 DOI: 10.1016/J.Bbrc.2007.08.165  0.398
2007 Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and Cellular Biology. 27: 7188-97. PMID 17709388 DOI: 10.1128/Mcb.00915-07  0.339
2007 Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (Baltimore, Md.). 46: 1597-610. PMID 17668877 DOI: 10.1002/Hep.21831  0.405
2007 Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. International Journal of Cancer. 121: 1883-91. PMID 17631644 DOI: 10.1002/Ijc.22943  0.344
2007 Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radical Biology & Medicine. 43: 408-14. PMID 17602956 DOI: 10.1016/J.Freeradbiomed.2007.04.020  0.336
2007 Iida K, Itoh K, Maher JM, Kumagai Y, Oyasu R, Mori Y, Shimazui T, Akaza H, Yamamoto M. Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. Carcinogenesis. 28: 2398-403. PMID 17602169 DOI: 10.1093/Carcin/Bgm146  0.315
2007 Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T, Yamamoto M. Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. Cancer Research. 67: 5643-8. PMID 17575130 DOI: 10.1158/0008-5472.Can-06-3355  0.35
2007 Kobayashi M, Yamamoto M. Regulation of GATA1 Gene Expression Journal of Biochemistry. 142: 1-10. PMID 17567656 DOI: 10.1093/Jb/Mvm122  0.424
2007 Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience. 147: 53-9. PMID 17507167 DOI: 10.1016/J.Neuroscience.2007.02.066  0.316
2007 Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang Cs, Yamamoto M, Tanimoto K, Engel JD. Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. The Embo Journal. 26: 2295-306. PMID 17431400 DOI: 10.1038/Sj.Emboj.7601676  0.347
2007 Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. American Journal of Respiratory Cell and Molecular Biology. 37: 3-8. PMID 17413030 DOI: 10.1165/Rcmb.2007-0004Rc  0.378
2007 Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD. A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development (Cambridge, England). 134: 1703-12. PMID 17395646 DOI: 10.1242/Dev.001297  0.375
2007 Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho HY, Kleeberger SR. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2237-46. PMID 17384144 DOI: 10.1096/Fj.06-7759Com  0.353
2007 Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M. GATA-1 self-association controls erythroid development in vivo Journal of Biological Chemistry. 282: 15862-15871. PMID 17374603 DOI: 10.1074/Jbc.M701936200  0.366
2007 Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 104: 3514-3519. PMID 17360675 DOI: 10.1073/Pnas.0608510104  0.316
2007 Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindern M, Ohneda K, Grosveld F, Yamamoto M, Philipsen S. Dynamic regulation of Gata factor levels is more important than their identity. Blood. 109: 5481-90. PMID 17327407 DOI: 10.1182/Blood-2006-11-060491  0.381
2007 Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M. Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. The Biochemical Journal. 404: 459-66. PMID 17313370 DOI: 10.1042/Bj20061611  0.396
2007 Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast Molecular and Cellular Biology. 27: 3154-3164. PMID 17261596 DOI: 10.1128/Mcb.01039-06  0.315
2007 Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, Osato M. Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia Blood. 109: 4023-4027. PMID 17244685 DOI: 10.1182/Blood-2006-01-031781  0.323
2007 Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics. 6: 154-62. PMID 17237276 DOI: 10.1158/1535-7163.Mct-06-0516  0.382
2007 Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, Noguchi N. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species. Free Radical Biology and Medicine. 42: 260-269. PMID 17189831 DOI: 10.1016/J.Freeradbiomed.2006.10.043  0.391
2007 Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. The Embo Journal. 26: 184-96. PMID 17159898 DOI: 10.1038/Sj.Emboj.7601480  0.338
2007 Motohashi H, Yamamoto M. Carcinogenesis and transcriptional regulation through Maf recognition elements. Cancer Science. 98: 135-139. PMID 17129360 DOI: 10.1111/J.1349-7006.2006.00358.X  0.373
2007 Kitamura Y, Umemura T, Kanki K, Kodama Y, Kitamoto S, Saito K, Itoh K, Yamamoto M, Masegi T, Nishikawa A, Hirose M. Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline. Cancer Science. 98: 19-24. PMID 17083568 DOI: 10.1111/J.1349-7006.2006.00352.X  0.343
2007 Mitani K, Eguchi-Ishimae M, Maki K, Shimizu R, Yamamoto M, Eguchi M. Leukemia-Related Transcription Factor TEL Expands Erythroid Precursors. Blood. 110: 4160-4160. DOI: 10.1182/Blood.V110.11.4160.4160  0.356
2007 Imagawa S, Horie M, Matsumoto K, Hirano I, Suzuki N, Yamamoto M. Detection of Hypoxia-Inducible Gene Manipulation. Blood. 110: 3662-3662. DOI: 10.1182/Blood.V110.11.3662.3662  0.326
2007 Fujiwara T, Okitsu Y, Ikura T, Takahashi S, Furuyama K, Igarashi K, Yamamoto M, Sassa S, Harigae H. Analyses of Heme-Regulated Genes during Erythoid Differentiation. Blood. 110: 2660-2660. DOI: 10.1182/Blood.V110.11.2660.2660  0.384
2007 Mukai HY, Kono T, Motohashi H, Yamamoto M, Kojima H. c-Myb Regulates CD9 Gene Expression during Megakaryopoiesis. Blood. 110: 1245-1245. DOI: 10.1182/Blood.V110.11.1245.1245  0.325
2007 Yamamoto M, Suzuki M, Suzuki N, Shimizu R. Regulation of mouse Gata1 gene expression in erythroid progenitors Blood Cells Molecules and Diseases. 38: 188. DOI: 10.1016/J.Bcmd.2006.10.153  0.372
2007 Tanabe O, Kobayashi S, Shen Y, McPhee D, Campbell AD, Yamamoto M, Tanimoto K, Engel D. 125Stage-specific, gene-selective regulation of the embryonic and fetal β-type globin genes by the orphan nuclear receptors TR2 and TR4 Blood Cells Molecules and Diseases. 38: 180. DOI: 10.1016/J.Bcmd.2006.10.136  0.304
2007 Suzuki M, Ohneda K, Yamamoto M. G1HE-core contributes to the stage-specific expression of the Gata1 gene during erythroid development Blood Cells Molecules and Diseases. 38: 180. DOI: 10.1016/J.Bcmd.2006.10.135  0.312
2007 Shimizu R, Fujita R, Ohmori S, Ottolenghi S, Ronchi A, Yamamoto M. Developmental regulation of Gata1 gene expression through adjacent GATA boxes and CP2-binding sites Blood Cells Molecules and Diseases. 38: 177. DOI: 10.1016/J.Bcmd.2006.10.128  0.332
2006 Koga S, Yamaguchi N, Abe T, Minegishi M, Tsuchiya S, Yamamoto M, Minegishi N. Cell-cycle–dependent oscillation of GATA2 expression in hematopoietic cells Blood. 109: 4200-4208. PMID 17255359 DOI: 10.1182/Blood-2006-08-044149  0.368
2006 Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications. 351: 883-9. PMID 17097057 DOI: 10.1016/J.Bbrc.2006.10.102  0.335
2006 Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proceedings of the National Academy of Sciences of the United States of America. 103: 17278-83. PMID 17088532 DOI: 10.1073/Pnas.0608357103  0.342
2006 Tong KI, Kobayashi A, Katsuoka F, Yamamoto M. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism Biological Chemistry. 387: 1311-1320. PMID 17081101 DOI: 10.1515/Bc.2006.164  0.355
2006 Sekine H, Mimura J, Yamamoto M, Fujii-Kuriyama Y. Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses. Journal of Biological Chemistry. 281: 37507-37516. PMID 17023418 DOI: 10.1074/Jbc.M606910200  0.402
2006 Sakurai T, Kanayama M, Shibata T, Itoh K, Kobayashi A, Yamamoto M, Uchida K. Ebselen, a Seleno-organic Antioxidant, as an Electrophile Chemical Research in Toxicology. 19: 1196-1204. PMID 16978024 DOI: 10.1021/Tx0601105  0.315
2006 Hosoya-Ohmura S, Mochizuki N, Suzuki M, Ohneda O, Ohneda K, Yamamoto M. GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo. The Journal of Biological Chemistry. 281: 32820-30. PMID 16945928 DOI: 10.1074/Jbc.M605735200  0.421
2006 Moriguchi T, Takako N, Hamada M, Maeda A, Fujioka Y, Kuroha T, Huber RE, Hasegawa SL, Rao A, Yamamoto M, Takahashi S, Lim KC, Engel JD. Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Development (Cambridge, England). 133: 3871-81. PMID 16943277 DOI: 10.1242/Dev.02553  0.398
2006 Mukai HY, Motohashi H, Ohneda O, Suzuki N, Nagano M, Yamamoto M. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Molecular and Cellular Biology. 26: 7953-65. PMID 16940183 DOI: 10.1128/Mcb.00718-06  0.382
2006 Zhang J, Ohta T, Maruyama A, Hosoya T, Nishikawa K, Maher JM, Shibahara S, Itoh K, Yamamoto M. BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Molecular and Cellular Biology. 26: 7942-52. PMID 16923960 DOI: 10.1128/Mcb.00700-06  0.396
2006 Matsumoto K, Imagawa S, Obara N, Suzuki N, Takahashi S, Nagasawa T, Yamamoto M. 2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis. Journal of Cellular Physiology. 209: 333-40. PMID 16883594 DOI: 10.1002/Jcp.20733  0.309
2006 Zhang Y, Crouch DH, Yamamoto M, Hayes JD. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. The Biochemical Journal. 399: 373-85. PMID 16872277 DOI: 10.1042/Bj20060725  0.347
2006 Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, et al. MafB is essential for renal development and F4/80 expression in macrophages. Molecular and Cellular Biology. 26: 5715-27. PMID 16847325 DOI: 10.1128/Mcb.00001-06  0.316
2006 Harigaya Y, Tanaka H, Yamanaka S, Tanaka K, Watanabe Y, Tsutsumi C, Chikashige Y, Hiraoka Y, Yamashita A, Yamamoto M. Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature. 442: 45-50. PMID 16823445 DOI: 10.1038/Nature04881  0.352
2006 Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. American Journal of Respiratory Cell and Molecular Biology. 35: 639-50. PMID 16794261 DOI: 10.1165/Rcmb.2005-0325Oc  0.367
2006 Zhu H, Zhang L, Itoh K, Yamamoto M, Ross D, Trush MA, Zweier JL, Li Y. Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. Free Radical Biology & Medicine. 41: 132-43. PMID 16781461 DOI: 10.1016/J.Freeradbiomed.2006.03.020  0.356
2006 Motohashi H, Katsuoka F, Miyoshi C, Uchimura Y, Saitoh H, Francastel C, Engel JD, Yamamoto M. MafG sumoylation is required for active transcriptional repression. Molecular and Cellular Biology. 26: 4652-63. PMID 16738329 DOI: 10.1128/Mcb.02193-05  0.366
2006 Nakajima O, Okano S, Harada H, Kusaka T, Gao X, Hosoya T, Suzuki N, Takahashi S, Yamamoto M. Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 685-700. PMID 16716198 DOI: 10.1111/J.1365-2443.2006.00973.X  0.307
2006 Yamamoto T, Kyo M, Kamiya T, Tanaka T, Engel JD, Motohashi H, Yamamoto M. Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 575-91. PMID 16716189 DOI: 10.1111/J.1365-2443.2006.00965.X  0.304
2006 Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M. C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development Developmental Biology. 295: 689-699. PMID 16678151 DOI: 10.1016/J.Ydbio.2006.04.002  0.349
2006 Otori M, Karashima T, Yamamoto M. The Caenorhabditis elegans homologue of Deleted in Azoospermia is involved in the sperm/oocyte switch Molecular Biology of the Cell. 17: 3147-3155. PMID 16641369 DOI: 10.1091/Mbc.E05-11-1067  0.334
2006 Yamashita A, Yamamoto M. Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase Genetics. 173: 1187-1196. PMID 16624923 DOI: 10.1534/Genetics.105.050062  0.306
2006 Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. The Journal of Clinical Investigation. 116: 984-95. PMID 16585964 DOI: 10.1172/Jci25790  0.362
2006 Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Molecular and Cellular Biology. 26: 2887-2900. PMID 16581765 DOI: 10.1128/Mcb.26.8.2887-2900.2006  0.31
2006 Suzuki M, Ohneda K, Hosoya-Ohmura S, Tsukamoto S, Ohneda O, Philipsen S, Yamamoto M. Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice. Blood. 108: 726-33. PMID 16537808 DOI: 10.1182/Blood-2005-10-4064  0.354
2006 Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer Molecular Cell. 21: 689-700. PMID 16507366 DOI: 10.1016/J.Molcel.2006.01.013  0.316
2006 Nagai H, Kubo M, Abe R, Yamamoto M, Nohara K. Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway. International Immunopharmacology. 6: 279-286. PMID 16399633 DOI: 10.1016/J.Intimp.2005.08.015  0.343
2006 Kobayashi A, Kang M, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Molecular and Cellular Biology. 26: 221-229. PMID 16354693 DOI: 10.1128/Mcb.26.1.221-229.2006  0.303
2006 Umemura T, Kuroiwa Y, Kitamura Y, Ishii Y, Kanki K, Kodama Y, Itoh K, Yamamoto M, Nishikawa A, Hirose M. A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol Toxicological Sciences. 90: 111-119. PMID 16352618 DOI: 10.1093/Toxsci/Kfj076  0.345
2006 Uwayama J, Hirayama A, Yanagawa T, Warabi E, Sugimoto R, Itoh K, Yamamoto M, Yoshida H, Koyama A, Ishii T. Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals. Biochemical and Biophysical Research Communications. 339: 226-231. PMID 16297875 DOI: 10.1016/J.Bbrc.2005.10.192  0.32
2006 Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochemical and Biophysical Research Communications. 339: 79-88. PMID 16293230 DOI: 10.1016/J.Bbrc.2005.10.185  0.405
2006 Zheng J, Kitajima K, Sakai E, Kimura T, Minegishi N, Yamamoto M, Nakano T. Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells. Blood. 107: 520-527. PMID 16174764 DOI: 10.1182/Blood-2005-04-1385  0.358
2006 Okitsu Y, Harigae H, Takahashi S, Minegishi N, Suzuki N, Kameoka J, Yamamoto M, Sasaki T. Phenotypic Changes of Hematopoietic Stem Cells and Stromal Cells by Aberrant Expression of GATA−2; Possible Role for the Development of Aplastic Anemia. Blood. 108: 1289-1289. DOI: 10.1182/Blood.V108.11.1289.1289  0.341
2006 Mukai HY, Motohashi H, Nagasawa T, Yamamoto M. Transgene Insertion into the Proximity of the c-myb Gene Disrupts Erythroid-Megakaryocytic Lineage Bifurcation. Blood. 108: 1172-1172. DOI: 10.1182/Blood.V108.11.1172.1172  0.359
2005 Fujiwara T, Harigae H, Takahashi S, Furuyama K, Nakajima O, Sun J, Igarashi K, Yamamoto M, Sassa S, Kaku M, Sasaki T. Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. Biochemical and Biophysical Research Communications. 340: 105-10. PMID 16356476 DOI: 10.1016/J.Bbrc.2005.11.163  0.359
2005 Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 1113-25. PMID 16324149 DOI: 10.1111/J.1365-2443.2005.00905.X  0.363
2005 Ishii Y, Itoh K, Morishima Y, Kimura T, Kiwamoto T, Iizuka T, Hegab AE, Hosoya T, Nomura A, Sakamoto T, Yamamoto M, Sekizawa K. Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. Journal of Immunology (Baltimore, Md. : 1950). 175: 6968-75. PMID 16272357 DOI: 10.4049/Jimmunol.175.10.6968  0.393
2005 Baba T, Mimura J, Nakamura N, Harada N, Yamamoto M, Morohashi K, Fujii-Kuriyama Y. Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction Molecular and Cellular Biology. 25: 10040-10051. PMID 16260617 DOI: 10.1128/Mcb.25.22.10040-10051.2005  0.373
2005 Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M. Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. Inflammopharmacology. 13: 83-90. PMID 16259730 DOI: 10.1163/156856005774423863  0.308
2005 Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya T, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M. Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Molecular and Cellular Biology. 25: 9360-8. PMID 16227587 DOI: 10.1128/Mcb.25.21.9360-9368.2005  0.307
2005 Katsuoka F, Motohashi H, Ishii T, Aburatani H, Engel JD, Yamamoto M. Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Molecular and Cellular Biology. 25: 8044-51. PMID 16135796 DOI: 10.1128/Mcb.25.18.8044-8051.2005  0.42
2005 Kobayashi-Osaki M, Ohneda O, Suzuki N, Minegishi N, Yokomizo T, Takahashi S, Lim KC, Engel JD, Yamamoto M. GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Molecular and Cellular Biology. 25: 7005-20. PMID 16055713 DOI: 10.1128/Mcb.25.16.7005-7020.2005  0.376
2005 Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. The Journal of Experimental Medicine. 202: 47-59. PMID 15998787 DOI: 10.1084/Jem.20050538  0.364
2005 Nishiyama C, Ito T, Nishiyama M, Masaki S, Maeda K, Nakano N, Ng W, Fukuyama K, Yamamoto M, Okumura K, Ogawa H. GATA-1 is required for expression of FcεRI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow International Immunology. 17: 847-856. PMID 15967781 DOI: 10.1093/Intimm/Dxh278  0.367
2005 Minegishi N, Suzuki N, Kawatani Y, Shimizu R, Yamamoto M. Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 693-704. PMID 15966900 DOI: 10.1111/J.1365-2443.2005.00864.X  0.379
2005 Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H, Oishi H, Hamada M, Morito N, Hasegawa K, Kudo T, Engel JD, Yamamoto M, Takahashi S. MafA is a key regulator of glucose-stimulated insulin secretion. Molecular and Cellular Biology. 25: 4969-76. PMID 15923615 DOI: 10.1128/Mcb.25.12.4969-4976.2005  0.326
2005 Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, Yamamoto M. Differential Responses of the Nrf2-Keap1 System to Laminar and Oscillatory Shear Stresses in Endothelial Cells* Journal of Biological Chemistry. 280: 27244-27250. PMID 15917255 DOI: 10.1074/Jbc.M502551200  0.321
2005 Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. Febs Letters. 579: 3029-36. PMID 15896789 DOI: 10.1016/J.Febslet.2005.04.058  0.333
2005 Usami H, Kusano Y, Kumagai T, Osada S, Itoh K, Kobayashi A, Yamamoto M, Uchida K. Selective Induction of the Tumor Marker Glutathione S-Transferase P1 by Proteasome Inhibitors Journal of Biological Chemistry. 280: 25267-25276. PMID 15863507 DOI: 10.1074/Jbc.M501014200  0.349
2005 Yanagida M, Osato M, Yamashita N, Liqun H, Jacob B, Wu F, Cao X, Nakamura T, Yokomizo T, Takahashi S, Yamamoto M, Shigesada K, Ito Y. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Oncogene. 24: 4477-85. PMID 15856017 DOI: 10.1038/Sj.Onc.1208675  0.346
2005 Kelly VP, Suzuki T, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M. The distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesis. Molecular and Cellular Biology. 25: 3658-3669. PMID 15831471 DOI: 10.1128/Mcb.25.9.3658-3669.2005  0.417
2005 Pan X, Ohneda O, Ohneda K, Lindeboom F, Iwata F, Shimizu R, Nagano M, Suwabe N, Philipsen S, Lim KC, Engel JD, Yamamoto M. Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors. The Journal of Biological Chemistry. 280: 22385-94. PMID 15817467 DOI: 10.1074/Jbc.M500081200  0.368
2005 Hirota A, Kawachi Y, Itoh K, Nakamura Y, Xu X, Banno T, Takahashi T, Yamamoto M, Otsuka F. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis. The Journal of Investigative Dermatology. 124: 825-32. PMID 15816842 DOI: 10.1111/J.0022-202X.2005.23670.X  0.357
2005 Izawa D, Goto M, Yamashita A, Yamano H, Yamamoto M. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p Nature. 434: 529-533. PMID 15791259 DOI: 10.1038/Nature03406  0.333
2005 Mochizuki M, Ishii Y, Itoh K, Iizuka T, Morishima Y, Kimura T, Kiwamoto T, Matsuno Y, Hegab AE, Nomura A, Sakamoto T, Uchida K, Yamamoto M, Sekizawa K. Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. American Journal of Respiratory and Critical Care Medicine. 171: 1260-6. PMID 15750045 DOI: 10.1164/Rccm.200406-755Oc  0.306
2005 Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C. Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. Journal of Immunology (Baltimore, Md. : 1950). 174: 2770-7. PMID 15728486 DOI: 10.4049/Jimmunol.174.5.2770  0.348
2005 Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxidants & Redox Signaling. 7: 385-394. PMID 15706085 DOI: 10.1089/Ars.2005.7.385  0.39
2005 Wu J, Iwata F, Grass JA, Osborne CS, Elnitski L, Fraser P, Ohneda O, Yamamoto M, Bresnick EH. Molecular determinants of NOTCH4 transcription in vascular endothelium. Molecular and Cellular Biology. 25: 1458-74. PMID 15684396 DOI: 10.1128/Mcb.25.4.1458-1474.2005  0.359
2005 Ferreira R, Ohneda K, Yamamoto M, Philipsen S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Molecular and Cellular Biology. 25: 1215-1227. PMID 15684376 DOI: 10.1128/Mcb.25.4.1215-1227.2005  0.377
2005 Ezoe S, Matsumura I, Gale K, Satoh Y, Ishikawa J, Mizuki M, Takahashi S, Minegishi N, Nakajima K, Yamamoto M, Enver T, Kanakura Y. GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. The Journal of Biological Chemistry. 280: 13163-70. PMID 15673499 DOI: 10.1074/Jbc.M413461200  0.339
2005 Nakano M, Ohneda K, Yamamoto-Mukai H, Shimizu R, Ohneda O, Ohmura S, Suzuki M, Tsukamoto S, Yanagawa T, Yoshida H, Takakuwa Y, Yamamoto M. Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 47-62. PMID 15670213 DOI: 10.1111/J.1365-2443.2005.00814.X  0.422
2005 Shimizu R, Yamamoto M. Gene expression regulation and domain function of hematopoietic GATA factors. Seminars in Cell & Developmental Biology. 16: 129-136. PMID 15659347 DOI: 10.1016/J.Semcdb.2004.11.001  0.349
2005 Suzuki T, Takagi Y, Osanai H, Li LI, Takeuchi M, Katoh Y, Kobayashi M, Yamamoto M. Pi class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish Biochemical Journal. 388: 65-73. PMID 15654768 DOI: 10.1042/Bj20041860  0.382
2005 Yamashita A, Sato M, Fujita A, Yamamoto M, Toda T. The roles of fission yeast Ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling Molecular Biology of the Cell. 16: 1378-1395. PMID 15647375 DOI: 10.1091/Mbc.E04-10-0859  0.301
2005 Cho HY, Reddy SP, Debiase A, Yamamoto M, Kleeberger SR. Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radical Biology & Medicine. 38: 325-43. PMID 15629862 DOI: 10.1016/J.Freeradbiomed.2004.10.013  0.414
2005 Toki T, Katsuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J, Kamio T, Watanabe S, Tandai S, Terui K, Yagihashi S, Komatsu N, Igarashi K, Yamamoto M, Ito E. Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Blood. 105: 3100-8. PMID 15613547 DOI: 10.1182/Blood-2004-07-2826  0.371
2005 Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, Shin H, Kawahara K, Ohneda O, Ohta T, Tanaka S, Yamamoto M, Maruyama I, Nishioka K, Fukamizu A, et al. Essential Role of Synoviolin in Embryogenesis Journal of Biological Chemistry. 280: 7909-7916. PMID 15611074 DOI: 10.1074/Jbc.M410863200  0.323
2005 Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Archives of Biochemistry and Biophysics. 433: 342-50. PMID 15581590 DOI: 10.1016/J.Abb.2004.10.012  0.334
2005 Katsuoka F, Motohashi H, Engel JD, Yamamoto M. Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. The Journal of Biological Chemistry. 280: 4483-90. PMID 15574414 DOI: 10.1074/Jbc.M411451200  0.388
2005 Maruyama R, Endo S, Sugimoto A, Yamamoto M. Caenorhabditis elegans DAZ-1 is expressed in proliferating germ cells and directs proper nuclear organization and cytoplasmic core formation during oogenesis Developmental Biology. 277: 142-154. PMID 15572146 DOI: 10.1016/J.Ydbio.2004.08.053  0.392
2005 Itoh K, Yamamoto M. Regulatory Role of the COX-2 Pathway in the Nrf2-Mediated Anti-Inflammatory Response Journal of Clinical Biochemistry and Nutrition. 37: 9-18. DOI: 10.3164/Jcbn.37.9  0.387
2005 Obara N, Suzuki N, Ki-Bom K, Imagawa S, Nagasawa T, Yamamoto M. GATA Motif on the Erythropoietin Gene Promoter Is Essential for Repression of Ectopic Constitutive Erythropoietin Production. Blood. 106: 3139-3139. DOI: 10.1182/Blood.V106.11.3139.3139  0.371
2005 Suzuki N, Obara N, Kim K, Pan X, Jishage K, Imagawa S, Yamamoto M. Essential Role and Regulatory Mechanism of the Erythropoietin Gene in the Liver. Blood. 106: 3138-3138. DOI: 10.1182/Blood.V106.11.3138.3138  0.356
2005 Kadri Z, Shimizu R, Gisselbrecht S, Ohneda O, Yamamoto M, Romeo PH, Chretien S. The Direct Association of GATA-1 to Rb Is Necessary for Definitive Erythropoiesis. Blood. 106: 309-309. DOI: 10.1182/Blood.V106.11.309.309  0.384
2005 Hamada M, Moriguchi T, Morito N, Zhang C, Hasegawa K, Yoh K, Kuroda E, Yokomizo T, Engel JD, Yamamoto M, Takahashi S. mafB Deficient Mouse Results in Impaired Macrophage Differentiation. Blood. 106: 2222-2222. DOI: 10.1182/Blood.V106.11.2222.2222  0.332
2005 Kobayashi-Osaki M, Ohneda O, Suzuki N, Minegishi N, Yokomizo T, Takahashi S, Lim KC, Engel JD, Yamamoto M. Erratum: GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene (Molecular and Cellular Biology (2005) 25, 16 (7005-7020)) Molecular and Cellular Biology. 25. DOI: 10.1128/Mcb.25.22.10202.2005  0.323
2004 Shimizu R, Kuroha T, Ohneda O, Pan X, Ohneda K, Takahashi S, Philipsen S, Yamamoto M. Leukemogenesis caused by incapacitated GATA-1 function. Molecular and Cellular Biology. 24: 10814-25. PMID 15572684 DOI: 10.1128/Mcb.24.24.10814-10825.2004  0.369
2004 McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates Journal of Nutrition. 134. PMID 15570060 DOI: 10.1093/Jn/134.12.3499S  0.384
2004 Khandekar M, Suzuki N, Lewton J, Yamamoto M, Engel JD. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Molecular and Cellular Biology. 24: 10263-76. PMID 15542836 DOI: 10.1128/Mcb.24.23.10263-10276.2004  0.341
2004 Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. The Journal of Clinical Investigation. 114: 1248-59. PMID 15520857 DOI: 10.1172/Jci21146  0.332
2004 Motohashi H, Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends in Molecular Medicine. 10: 549-557. PMID 15519281 DOI: 10.1016/J.Molmed.2004.09.003  0.413
2004 Suzuki N, Imagawa S, Noguchi CT, Yamamoto M. Do beta-globin, GATA-1,or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? Blood. 104: 2988; author reply 2. PMID 15498861 DOI: 10.1182/Blood-2004-06-2081  0.321
2004 Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Research. 64: 6424-6431. PMID 15374950 DOI: 10.1158/0008-5472.Can-04-1906  0.349
2004 Yamamoto T, Yoh K, Kobayashi A, Ishii Y, Kure S, Koyama A, Sakamoto T, Sekizawa K, Motohashi H, Yamamoto M. Identification of polymorphisms in the promoter region of the human NRF2 gene Biochemical and Biophysical Research Communications. 321: 72-79. PMID 15358217 DOI: 10.1016/J.Bbrc.2004.06.112  0.343
2004 Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Molecular and Cellular Biology. 24: 7130-9. PMID 15282312 DOI: 10.1128/Mcb.24.16.7130-7139.2004  0.302
2004 Cho HY, Reddy SP, Yamamoto M, Kleeberger SR. The transcription factor NRF2 protects against pulmonary fibrosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1258-60. PMID 15208274 DOI: 10.1096/Fj.03-1127Fje  0.372
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