| Year |
Citation |
Score |
| 2022 |
Ding Q, Chorazyczewski J, Gros R, Motulsky HJ, Limbird LE, Feldman RD. Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist. Pharmacology Research & Perspectives. 10: e00995. PMID 36065843 DOI: 10.1002/prp2.995 |
0.403 |
|
| 2015 |
Feldman RD, Limbird LE. Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe. Trends in Endocrinology and Metabolism: Tem. 26: 592-4. PMID 26482875 DOI: 10.1016/j.tem.2015.09.002 |
0.46 |
|
| 2011 |
Limbird LE. Historical perspective for understanding of adrenergic receptors. Current Topics in Membranes. 67: 1-17. PMID 21771483 DOI: 10.1016/B978-0-12-384921-2.00001-X |
0.423 |
|
| 2011 |
Brady AE, Chen Y, Limbird LE, Wang Q. Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 746: 347-55. PMID 21607867 DOI: 10.1007/978-1-61779-126-0_19 |
0.77 |
|
| 2010 |
Lu R, Chen Y, Cottingham C, Peng N, Jiao K, Limbird LE, Wyss JM, Wang Q. Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Molecular Pharmacology. 78: 279-86. PMID 20430865 DOI: 10.1124/mol.110.065300 |
0.417 |
|
| 2009 |
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. The Journal of Biological Chemistry. 284: 13233-43. PMID 19276088 DOI: 10.1074/Jbc.M807535200 |
0.46 |
|
| 2009 |
Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. The Journal of Biological Chemistry. 284: 5742-52. PMID 19106094 DOI: 10.1074/jbc.M808507200 |
0.382 |
|
| 2009 |
Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behavioural Brain Research. 197: 457-61. PMID 18957308 DOI: 10.1016/j.bbr.2008.09.036 |
0.39 |
|
| 2007 |
Wang Q, Limbird LE. Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochemical Pharmacology. 73: 1135-45. PMID 17229402 DOI: 10.1016/j.bcp.2006.12.024 |
0.345 |
|
| 2006 |
Wang Q, Lu R, Zhao J, Limbird LE. Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. The Journal of Biological Chemistry. 281: 25948-55. PMID 16809338 DOI: 10.1074/jbc.M605415200 |
0.386 |
|
| 2005 |
Brady AE, Wang Q, Allen PB, Rizzo M, Greengard P, Limbird LE. Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype. Molecular Pharmacology. 67: 1690-6. PMID 15705742 DOI: 10.1124/Mol.104.005215 |
0.803 |
|
| 2004 |
Limbird LE. The receptor concept: a continuing evolution. Molecular Interventions. 4: 326-36. PMID 15616162 DOI: 10.1124/mi.4.6.6 |
0.469 |
|
| 2004 |
Zhang YQ, Limbird LE. Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles. Biochemical Society Transactions. 32: 856-60. PMID 15494033 DOI: 10.1042/BST0320856 |
0.393 |
|
| 2004 |
Nickols HH, Shah VN, Chazin WJ, Limbird LE. Calmodulin interacts with the V2 vasopressin receptor: elimination of binding to the C terminus also eliminates arginine vasopressin-stimulated elevation of intracellular calcium. The Journal of Biological Chemistry. 279: 46969-80. PMID 15319442 DOI: 10.1074/Jbc.M407351200 |
0.75 |
|
| 2004 |
Brady AE, Wang Q, Limbird LE. Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 259: 371-8. PMID 15250505 DOI: 10.1385/1-59259-754-8:371 |
0.771 |
|
| 2004 |
Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/Science.1098274 |
0.806 |
|
| 2004 |
Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE. Membrane trafficking of G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 44: 559-609. PMID 14744258 DOI: 10.1146/Annurev.Pharmtox.44.101802.121558 |
0.799 |
|
| 2004 |
Limbird LE. α2-Adrenergic Receptors Primer On the Autonomic Nervous System: Second Edition. 54-56. DOI: 10.1016/B978-012589762-4/50013-X |
0.325 |
|
| 2003 |
Tan CM, Nickols HH, Limbird LE. Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves a conformation of the receptor that also attains mature glycosylation. The Journal of Biological Chemistry. 278: 35678-86. PMID 12824183 DOI: 10.1074/Jbc.M301888200 |
0.754 |
|
| 2003 |
Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. The Journal of Biological Chemistry. 278: 32405-12. PMID 12738775 DOI: 10.1074/Jbc.M304195200 |
0.753 |
|
| 2002 |
Wang Q, Limbird LE. Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. The Journal of Biological Chemistry. 277: 50589-96. PMID 12376539 DOI: 10.1074/jbc.M208503200 |
0.387 |
|
| 2002 |
Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8771-7. PMID 12351753 |
0.468 |
|
| 2002 |
Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 99: 12471-6. PMID 12205290 DOI: 10.1073/Pnas.122368499 |
0.558 |
|
| 2002 |
Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cellular Signalling. 14: 297-309. PMID 11858937 DOI: 10.1016/S0898-6568(01)00239-X |
0.786 |
|
| 2002 |
Wozniak M, Saunders C, Schramm N, Keefer JR, Limbird LE. Morphological and biochemical strategies for monitoring trafficking of epitope-tagged G protein-coupled receptors in agonist-naive and agonist-occupied states. Methods in Enzymology. 343: 530-44. PMID 11665590 DOI: 10.1016/S0076-6879(02)43156-4 |
0.811 |
|
| 2002 |
Tan CM, Limbird LE. Receptors in disease: A focus on G protein-coupled receptors Pharmaceutical News. 9: 327-336. DOI: 10.1080/10718940216620 |
0.538 |
|
| 2001 |
Schramm NL, McDonald MP, Limbird LE. The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4875-82. PMID 11425914 |
0.765 |
|
| 2001 |
Wilson MH, Highfield HA, Limbird LE. The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover. Molecular Pharmacology. 59: 929-38. PMID 11259639 |
0.46 |
|
| 2001 |
Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. The Journal of Biological Chemistry. 276: 15003-8. PMID 11154706 DOI: 10.1074/Jbc.M011679200 |
0.779 |
|
| 2000 |
Edwards SW, Tan CM, Limbird LE. Localization of G-protein-coupled receptors in health and disease. Trends in Pharmacological Sciences. 21: 304-8. PMID 10918636 DOI: 10.1016/S0165-6147(00)01513-3 |
0.448 |
|
| 2000 |
Kingery WS, Guo TZ, Davies MF, Limbird L, Maze M. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. 85: 345-58. PMID 10781908 DOI: 10.1016/S0304-3959(99)00286-9 |
0.405 |
|
| 2000 |
Wilson MH, Limbird LE. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. 39: 693-700. PMID 10651634 DOI: 10.1021/bi9920275 |
0.44 |
|
| 2000 |
Saunders C, Limbird LE. Microtubule-dependent regulation of alpha(2B) adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling. Molecular Pharmacology. 57: 44-52. PMID 10617677 |
0.384 |
|
| 1999 |
Saunders C, Limbird LE. Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues. Pharmacology & Therapeutics. 84: 193-205. PMID 10596906 DOI: 10.1016/S0163-7258(99)00032-7 |
0.479 |
|
| 1999 |
Schramm NL, Limbird LE. Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. The Journal of Biological Chemistry. 274: 24935-40. PMID 10455169 DOI: 10.1074/jbc.274.35.24935 |
0.801 |
|
| 1999 |
Hein L, Limbird LE, Eglen RM, Kobilka BK. Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines. Annals of the New York Academy of Sciences. 881: 265-71. PMID 10415924 DOI: 10.1111/J.1749-6632.1999.Tb09368.X |
0.6 |
|
| 1999 |
Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. 56: 154-61. PMID 10385696 DOI: 10.1124/Mol.56.1.154 |
0.618 |
|
| 1999 |
Limbird LE, Vaughan DE. Augmenting beta receptors in the heart: short-term gains offset by long-term pains? Proceedings of the National Academy of Sciences of the United States of America. 96: 7125-7. PMID 10377378 DOI: 10.1073/Pnas.96.13.7125 |
0.393 |
|
| 1999 |
Edwards SW, Limbird LE. Role for the third intracellular loop in cell surface stabilization of the alpha2A-adrenergic receptor. The Journal of Biological Chemistry. 274: 16331-6. PMID 10347190 DOI: 10.1074/jbc.274.23.16331 |
0.364 |
|
| 1999 |
Prezeau L, Richman JG, Edwards SW, Limbird LE. The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. The Journal of Biological Chemistry. 274: 13462-9. PMID 10224112 DOI: 10.1074/jbc.274.19.13462 |
0.449 |
|
| 1998 |
MacMillan LB, Lakhlani P, Lovinger D, Limbird LE. Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings. Recent Progress in Hormone Research. 53: 25-42. PMID 9769701 |
0.362 |
|
| 1998 |
Saunders C, Keefer JR, Bonner CA, Limbird LE. Targeting of G protein-coupled receptors to the basolateral surface of polarized renal epithelial cells involves multiple, non-contiguous structural signals. The Journal of Biological Chemistry. 273: 24196-206. PMID 9727043 DOI: 10.1074/jbc.273.37.24196 |
0.321 |
|
| 1998 |
Wozniak M, Limbird LE. Trafficking itineraries of G protein-coupled receptors in epithelial cells do not predict receptor localization in neurons. Brain Research. 780: 311-22. PMID 9507174 DOI: 10.1016/S0006-8993(97)01216-X |
0.404 |
|
| 1998 |
Janumpalli S, Butler LS, MacMillan LB, Limbird LE, McNamara JO. A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2004-8. PMID 9482787 DOI: 10.1523/Jneurosci.18-06-02004.1998 |
0.433 |
|
| 1998 |
MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. Advances in Pharmacology (San Diego, Calif.). 42: 493-6. PMID 9327947 DOI: 10.1016/S1054-3589(08)60796-6 |
0.301 |
|
| 1997 |
Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 9950-5. PMID 9275232 DOI: 10.1073/pnas.94.18.9950 |
0.359 |
|
| 1997 |
Saunders C, Limbird LE. Disruption of microtubules reveals two independent apical targeting mechanisms for G-protein-coupled receptors in polarized renal epithelial cells. The Journal of Biological Chemistry. 272: 19035-45. PMID 9228087 DOI: 10.1074/jbc.272.30.19035 |
0.39 |
|
| 1997 |
Wozniak M, Keefer JR, Saunders C, Limbird LE. Differential targeting and retention of G protein-coupled receptors in polarized epithelial cells. Journal of Receptor and Signal Transduction Research. 17: 373-83. PMID 9029502 DOI: 10.3109/10799899709036615 |
0.493 |
|
| 1997 |
MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes Advances in Pharmacology. 42: 493-496. DOI: 10.1016/S1054-3589(08)60796-6 |
0.389 |
|
| 1996 |
Wang R, Macmillan LB, Fremeau RT, Magnuson MA, Lindner J, Limbird LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience. 74: 199-218. PMID 8843087 DOI: 10.1016/0306-4522(96)00116-9 |
0.418 |
|
| 1996 |
Lakhlani PP, Lovinger DM, Limbird LE. Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling. Molecular Pharmacology. 50: 96-103. PMID 8700125 |
0.422 |
|
| 1996 |
MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science (New York, N.Y.). 273: 801-3. PMID 8670421 DOI: 10.1126/Science.273.5276.801 |
0.393 |
|
| 1996 |
Lanier SM, Lafontan M, Limbird LE, Paris H. Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995. The Journal of Pharmacology and Experimental Therapeutics. 277: 10-6. PMID 8613905 |
0.412 |
|
| 1996 |
Saunders C, Keefer JR, Kennedy AP, Wells JN, Limbird LE. Receptors coupled to pertussis toxin-sensitive G-proteins traffic to opposite surfaces in Madin-Darby canine kidney cells. A1 adenosine receptors achieve apical and alpha 2A adrenergic receptors achieve basolateral localization. The Journal of Biological Chemistry. 271: 995-1002. PMID 8557716 DOI: 10.1074/jbc.271.2.995 |
0.451 |
|
| 1996 |
Saunders C, Keefer JR, Limbird LE. Receptor chimeras and truncations reveal α2a adrenergic receptor (a2aar) domains involved in its basolateral localization in mdckii cells Faseb Journal. 10: A419. |
0.406 |
|
| 1994 |
Keefer JR, Kennedy ME, Limbird LE. Unique structural features important for stabilization versus polarization of the alpha 2A-adrenergic receptor on the basolateral membrane of Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 16425-32. PMID 8206950 |
0.378 |
|
| 1994 |
Kennedy ME, Limbird LE. Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation. The Journal of Biological Chemistry. 269: 31915-22. PMID 7989367 |
0.417 |
|
| 1994 |
Ceresa BP, Limbird LE. Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling. The Journal of Biological Chemistry. 269: 29557-64. PMID 7961941 |
0.502 |
|
| 1994 |
Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086 |
0.492 |
|
| 1994 |
Keefer JR, Nunnari J, Pang IH, Limbird LE. Introduction of purified alpha 2A-adrenergic receptors into uniformly oriented, unilamellar, phospholipid vesicles: productive coupling to G proteins but lack of receptor-dependent ion transport. Molecular Pharmacology. 45: 1071-81. PMID 7517495 |
0.714 |
|
| 1993 |
Keefer JR, Limbird LE. The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins. The Journal of Biological Chemistry. 268: 11340-7. PMID 8388390 |
0.422 |
|
| 1993 |
Kennedy ME, Limbird LE. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. The Journal of Biological Chemistry. 268: 8003-11. PMID 8385131 |
0.508 |
|
| 1992 |
Domino SE, Repaske MG, Bonner CA, Kennedy ME, Wilson AL, Brandon S, Limbird LE. Synthesis of a yohimbine-agarose matrix useful for large-scale and micropurification of multiple alpha 2-receptor subtypes. Methods in Enzymology. 215: 181-200. PMID 1359387 DOI: 10.1016/0076-6879(92)15063-I |
0.43 |
|
| 1992 |
Surprenant A, Horstman DA, Akbarali H, Limbird LE. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science (New York, N.Y.). 257: 977-80. PMID 1354394 |
0.397 |
|
| 1992 |
Wilson AL, Womble SW, Prakash C, Cragoe EJ, Blair IA, Limbird LE. Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. Molecular Pharmacology. 42: 175-9. PMID 1325028 |
0.407 |
|
| 1991 |
Wilson AL, Seibert K, Brandon S, Cragoe EJ, Limbird LE. Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype. Molecular Pharmacology. 39: 481-6. PMID 1850091 |
0.412 |
|
| 1990 |
Clarke JD, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism. The American Journal of Physiology. 259: F977-85. PMID 2175564 |
0.431 |
|
| 1990 |
Horstman DA, Brandon S, Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. The Journal of Biological Chemistry. 265: 21590-5. PMID 2174879 |
0.495 |
|
| 1990 |
Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. The hydrophobic tryptic core of the porcine alpha 2-adrenergic receptor retains allosteric modulation of binding by Na+, H+, and 5-amino-substituted amiloride analogs. The Journal of Biological Chemistry. 265: 17318-22. PMID 2170372 |
0.397 |
|
| 1990 |
Guyer CA, Horstman DA, Wilson AL, Clark JD, Cragoe EJ, Limbird LE. Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. The Journal of Biological Chemistry. 265: 17307-17. PMID 2170371 |
0.483 |
|
| 1988 |
Sweatt JD, Connolly TM, Baron BM, Limbird LE. Involvement of Na+/H+ exchange in human platelet activation. Progress in Clinical and Biological Research. 283: 523-57. PMID 2850577 |
0.451 |
|
| 1988 |
Limbird LE. Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2686-95. PMID 2840317 |
0.429 |
|
| 1987 |
Nunnari JM, Repaske MG, Brandon S, Cragoe EJ, Limbird LE. Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange. The Journal of Biological Chemistry. 262: 12387-92. PMID 3040742 |
0.71 |
|
| 1987 |
Repaske MG, Nunnari JM, Limbird LE. Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix. The Journal of Biological Chemistry. 262: 12381-6. PMID 3040741 |
0.722 |
|
| 1987 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for alpha 2-adrenergic receptors. Hypertension. 9: III120-4. PMID 2885270 DOI: 10.1161/01.HYP.9.6_Pt_2.III120 |
0.696 |
|
| 1987 |
Isom LL, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. The Journal of Biological Chemistry. 262: 6750-7. PMID 2883187 |
0.449 |
|
| 1987 |
Isom LL, Cragoe EJ, Limbird LE. Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. The Journal of Biological Chemistry. 262: 17504-9. PMID 2826423 |
0.44 |
|
| 1987 |
Sweatt JD, Schwartzberg MS, Frazer M, Cragoe EJ, Blair IA, Reed PW, Limbird LE. Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. Circulation Research. 61: II6-11. PMID 2822286 |
0.459 |
|
| 1987 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for α2-adrenergic receptors Hypertension. 9: III-120-III-124. |
0.302 |
|
| 1986 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Photoaffinity labeling of the porcine brain alpha 2-adrenergic receptor using a radioiodinated arylazide derivative of rauwolscine: identification of the hormone-binding subunit. Proceedings of the National Academy of Sciences of the United States of America. 83: 9358-62. PMID 3025837 DOI: 10.1073/pnas.83.24.9358 |
0.706 |
|
| 1986 |
Sweatt JD, Connolly TM, Cragoe EJ, Limbird LE. Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. The Journal of Biological Chemistry. 261: 8667-73. PMID 3013859 |
0.512 |
|
| 1986 |
Sweatt JD, Blair IA, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. The Journal of Biological Chemistry. 261: 8660-6. PMID 3013858 |
0.474 |
|
| 1985 |
Sweatt JD, Johnson SL, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. The Journal of Biological Chemistry. 260: 12910-9. PMID 2997148 |
0.492 |
|
| 1985 |
Limbird LE, Connolly TM, Sweatt JD, Uderman HD. Human platelet alpha 2-adrenergic receptors: effect of Na+ on interaction with the adenylate cyclase system and on epinephrine-stimulated platelet secretion. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 235-42. PMID 2988299 |
0.601 |
|
| 1985 |
Limbird LE, MacMillan ST, Kalinoski DL. The resolution of agonist alpha 2-adrenergic receptor complexes from unoccupied receptors or antagonist-alpha 2 receptor complexes using DEAE chromatography. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 10: 75-82. PMID 2858502 |
0.497 |
|
| 1985 |
Sweatt JD, Limbird LE. Na+ and fibrinogen are required for release of arachidonic acid (AA) from human platelets in response to epinephrine, ADP and 0.004 U/ml thrombin Federation Proceedings. 44: No. 7341. |
0.441 |
|
| 1984 |
Segaloff DL, May J, Schomberg DW, Limbird LE. A model system for the biochemical study of luteinizing hormone/chorionic gonadotropin receptor synthesis. Biochimica Et Biophysica Acta. 804: 31-6. PMID 6326843 DOI: 10.1016/0167-4889(84)90095-8 |
0.369 |
|
| 1984 |
Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Leukocyte beta-receptor alterations in hypertensive subjects. The Journal of Clinical Investigation. 73: 648-53. PMID 6323524 DOI: 10.1172/JCI111255 |
0.326 |
|
| 1984 |
Limbird LE. GTP and Na+ modulate receptor-adenyl cyclase coupling and receptor-mediated function. The American Journal of Physiology. 247: E59-68. PMID 6146263 |
0.468 |
|
| 1984 |
Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. The New England Journal of Medicine. 310: 815-9. PMID 6142419 DOI: 10.1056/NEJM198403293101303 |
0.364 |
|
| 1983 |
Connolly TM, Limbird LE. Removal of extraplatelet Na+ eliminates indomethacin-sensitive secretion from human platelets stimulated by epinephrine, ADP, and thrombin. Proceedings of the National Academy of Sciences of the United States of America. 80: 5320-4. PMID 6577431 DOI: 10.1073/Pnas.80.17.5320 |
0.586 |
|
| 1983 |
Segaloff DL, Limbird LE. Luteinizing hormone receptor appearance in cultured porcine granulosa cells requires continual presence of follicle-stimulating hormone. Proceedings of the National Academy of Sciences of the United States of America. 80: 5631-5. PMID 6310585 |
0.371 |
|
| 1983 |
Limbird LE, Buhrow SA, Speck JL, Staros JV. 5'-p-Fluorosulfonylbenzoyl guanosine as a probe for the GTP-binding protein in alpha 2-adrenergic receptor-adenylate cyclase systems. The Journal of Biological Chemistry. 258: 10289-93. PMID 6309799 |
0.429 |
|
| 1983 |
Feldman RD, Limbird LE, Nadeau J, FitzGerald GA, Robertson D, Wood AJ. Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. The Journal of Clinical Investigation. 72: 164-70. PMID 6308044 DOI: 10.1172/Jci110954 |
0.395 |
|
| 1983 |
Segaloff DL, Limbird LE. The cAMP-Dependent induction of LH receptors in primary cultures of porcine granulosa cells is not due to the expression of an intracellular pool of LH receptors. Endocrinology. 113: 825-7. PMID 6307657 DOI: 10.1210/Endo-113-2-825 |
0.458 |
|
| 1983 |
Connolly TM, Limbird LE. The influence of Na+ on the alpha 2-adrenergic receptor system of human platelets. A method for removal of extraplatelet Na+. Effect of Na+ removal on aggregation, secretion, and cAMP accumulation. The Journal of Biological Chemistry. 258: 3907-12. PMID 6300061 |
0.318 |
|
| 1983 |
Limbird LE, Speck JL. N-ethylmaleimide, elevated temperature, and digitonin solubilization eliminate guanine nucleotide but not sodium effects on human platelet alpha 2-adrenergic receptor-agonist interactions. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 9: 191-201. PMID 6142062 |
0.503 |
|
| 1983 |
Limbird LE. Beta-adrenergic stimulation of adenylate cyclase and alpha-adrenergic inhibition of adenylate cyclase: GTP-binding proteins as macromolecular messengers. Advances in Experimental Medicine and Biology. 161: 91-111. PMID 6135310 |
0.337 |
|
| 1982 |
Smith SK, Limbird LE. Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin. The Journal of Biological Chemistry. 257: 10471-8. PMID 6286654 |
0.533 |
|
| 1982 |
Limbird LE, Speck JL, Smith SK. Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations. Molecular Pharmacology. 21: 609-17. PMID 6125876 |
0.405 |
|
| 1982 |
Smith SK, Limbird LE. Apparent independence of the alpha-adrenergic receptor (α-AR) of the human platelet from the ADP-ribosylated 42,000 Mr subunit of the adenylate cyclase system Federation Proceedings. 41: No. 3682. |
0.393 |
|
| 1981 |
Limbird LE. Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling. The Biochemical Journal. 195: 1-13. PMID 6272740 |
0.429 |
|
| 1981 |
Smith SK, Limbird LE. Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions. Proceedings of the National Academy of Sciences of the United States of America. 78: 4026-30. PMID 6270654 |
0.496 |
|
| 1981 |
Lefkowitz RJ, De Lean A, Hoffman BB, Stadel JM, Kent R, Michel T, Limbird L. Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. Advances in Cyclic Nucleotide Research. 14: 145-61. PMID 6269377 |
0.576 |
|
| 1981 |
Stadel JM, Shorr RG, Limbird LE, Lefkowitz RJ. Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. The Journal of Biological Chemistry. 256: 8718-23. PMID 6267049 |
0.545 |
|
| 1981 |
Limbird LE, MacMillan ST, Smith SK. Solubilization of human platelet alpha-adrenergic receptors: evidence for agonist-promoted receptor-effector association. Advances in Cyclic Nucleotide Research. 14: 189-98. PMID 6116384 |
0.468 |
|
| 1980 |
Limbird LE, Gill DM, Lefkowitz RJ. Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proceedings of the National Academy of Sciences of the United States of America. 77: 775-9. PMID 6244585 DOI: 10.1073/Pnas.77.2.775 |
0.609 |
|
| 1980 |
Limbird LE, Gill DM, Stadel JM, Hickey AR, Lefkowitz RJ. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. The Journal of Biological Chemistry. 255: 1854-61. PMID 6243651 |
0.527 |
|
| 1979 |
Limbird LE, Hickey AR, Lefkowitz RJ. The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. Journal of Cyclic Nucleotide Research. 5: 251-9. PMID 573291 |
0.493 |
|
| 1979 |
Limbird LE, Hickey AR, Lefkowitz RJ. Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. The Journal of Biological Chemistry. 254: 2677-83. PMID 429310 |
0.398 |
|
| 1979 |
Caron MG, Limbird LE, Lefkowitz RJ. Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. Molecular and Cellular Biochemistry. 28: 45-66. PMID 231201 DOI: 10.1007/BF00223359 |
0.676 |
|
| 1979 |
Limbird LE, DeLean A, Hickey AR, Pike LJ, Lefkowitz RJ. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. Biochimica Et Biophysica Acta. 586: 298-314. PMID 224939 DOI: 10.1016/0304-4165(79)90101-6 |
0.753 |
|
| 1979 |
Pike LJ, Limbird LE, Lefkowitz RJ. Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. Nature. 280: 502-4. PMID 37448 DOI: 10.1038/280502A0 |
0.678 |
|
| 1978 |
Lefkowitz RJ, Limbird LE, Williams LT, Wessels M. Beta-adrenergic receptors: regulatory role of agonists. Journal of Supramolecular Structure. 8: 501-10. PMID 31515 DOI: 10.1002/Jss.400080412 |
0.793 |
|
| 1978 |
Limbird LE, Lefkowitz RJ. Agonist-induced increase in apparent beta-adrenergic receptor size. Proceedings of the National Academy of Sciences of the United States of America. 75: 228-32. PMID 24213 DOI: 10.1073/Pnas.75.1.228 |
0.575 |
|
| 1978 |
Limbird LE, Lefkowitz RJ. Agonist induced increase in apparent β-adrenergic receptor size Federation Proceedings. 37: No.718. |
0.495 |
|
| 1977 |
Limbird LE, Lefkowitz RJ. Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. The Journal of Biological Chemistry. 252: 799-802. PMID 833154 |
0.558 |
|
| 1977 |
Limbird LE, Lefkowitz RJ. Separation of β-adrenergic receptors (βAR) from adenylate cyclase (AC) Federation Proceedings. 36: No.2437. |
0.322 |
|
| 1976 |
Limbird LE, Lefkowitz RJ. Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. Molecular Pharmacology. 12: 559-67. PMID 958206 |
0.551 |
|
| 1976 |
Limbird LE, Lefkowitz RJ. Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. The Journal of Biological Chemistry. 251: 5007-14. PMID 956174 |
0.534 |
|
| 1976 |
Lefkowitz RJ, Mukherjee C, Limbird LE, Caron MG, Williams LT, Alexander RW, Mickey JV, Tate R. Regulation of adenylate cyclase coupled beta-adrenergic receptors. Recent Progress in Hormone Research. 32: 597-632. PMID 785560 |
0.621 |
|
| 1976 |
Lefkowitz RJ, Limbird LE, Mukherjee C, Caron MG. The beta-adrenergic receptor and adenylate cyclase. Biochimica Et Biophysica Acta. 457: 1-39. PMID 769837 DOI: 10.1016/0304-4157(76)90012-5 |
0.627 |
|
| 1976 |
Lefkowitz RJ, Limbird LE. Techniques for the study of the biochemical basis of drug action. Progress in Cardiovascular Diseases. 18: 309-21. PMID 737 DOI: 10.1016/0033-0620(76)90024-4 |
0.301 |
|
| 1975 |
Limbird LE, Meyts PD, Lefkowitz RJ. Beta-adrenergic receptors: evidence for negative cooperativity. Biochemical and Biophysical Research Communications. 64: 1160-8. PMID 1137592 DOI: 10.1016/0006-291X(75)90815-3 |
0.519 |
|
| 1975 |
Limbird LE, Lefkowitz RJ. Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. Biochimica Et Biophysica Acta. 377: 186-96. PMID 235292 DOI: 10.1016/0005-2744(75)90299-5 |
0.39 |
|
| 1975 |
Limbird L, Lefkowitz R. Effects of membrane perturbation on β adrenergic receptor binding and adenylate cyclase activation Federation Proceedings. 34: No.643. |
0.325 |
|
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