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John Collinge, BSc, MB, ChB, MD, FRCP, FRS - Publications

Affiliations: 
Neurodegenerative Diseases University College London, London, United Kingdom 
Area:
http://www.biomedexperts.com/Profile.bme/255990/John_Collinge
Website:
http://www.ion.ucl.ac.uk/departments/neurodegeneration
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372 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jones E, Hill E, Linehan J, Nazari T, Caulder A, Codner GF, Hutchison M, Mackenzie M, Farmer M, Coysh T, De Oliveira MW, Al-Doujaily H, Sandberg M, Viré E, Cunningham TJ, ... ... Collinge J, et al. Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6. Neurobiology of Disease. 190: 106363. PMID 37996040 DOI: 10.1016/j.nbd.2023.106363  0.428
2022 Jackson GS, Linehan J, Brandner S, Asante EA, Wadsworth JDF, Collinge J. Overexpression of mouse prion protein in transgenic mice causes a non-transmissible spongiform encephalopathy. Scientific Reports. 12: 17198. PMID 36229637 DOI: 10.1038/s41598-022-21608-3  0.335
2022 Corbie R, Campbell T, Darwent L, Rudge P, Collinge J, Mead S. Estimation of the number of inherited prion disease mutation carriers in the UK. European Journal of Human Genetics : Ejhg. PMID 35754056 DOI: 10.1038/s41431-022-01132-8  0.312
2022 Reilly M, Benilova I, Khalili-Shirazi A, Schmidt C, Ahmed P, Yip D, Jat PS, Collinge J. A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody. Scientific Reports. 12: 9493. PMID 35680944 DOI: 10.1038/s41598-022-13455-z  0.4
2021 Mok TH, Nihat A, Luk C, Sequeira D, Batchelor M, Mead S, Collinge J, Jackson GS. Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases. Scientific Reports. 11: 5231. PMID 33664355 DOI: 10.1038/s41598-021-84527-9  0.305
2021 Wadsworth JDF, Joiner S, Linehan JM, Jack K, Al-Doujaily H, Costa H, Ingold T, Taema M, Zhang F, Sandberg MK, Brandner S, Tran L, Vikøren T, Våge J, Madslien K, ... ... Collinge J, et al. Humanised transgenic mice are resistant to chronic wasting disease prions from Norwegian reindeer and moose. The Journal of Infectious Diseases. PMID 33502474 DOI: 10.1093/infdis/jiab033  0.317
2020 Lauwers E, Lalli G, Brandner S, Collinge J, Compernolle V, Duyckaerts C, Edgren G, Haïk S, Hardy J, Helmy A, Ivinson AJ, Jaunmuktane Z, Jucker M, Knight R, Lemmens R, et al. Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878. PMID 32949547 DOI: 10.1016/S1474-4422(20)30238-6  0.494
2020 Jones E, Hummerich H, Viré E, Uphill J, Dimitriadis A, Speedy H, Campbell T, Norsworthy P, Quinn L, Whitfield J, Linehan J, Jaunmuktane Z, Brandner S, Jat P, Nihat A, ... ... Collinge J, et al. Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study. The Lancet. Neurology. 19: 840-848. PMID 32949544 DOI: 10.1016/S1474-4422(20)30273-8  0.433
2020 C Dabin L, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, Collinge J, Mead S, Viré E. Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease. Acta Neuropathologica. PMID 32918118 DOI: 10.1007/S00401-020-02224-9  0.398
2020 Benilova I, Reilly M, Terry C, Wenborn A, Schmidt C, Marinho AT, Risse E, Al-Doujaily H, Wiggins De Oliveira M, Sandberg MK, Wadsworth JDF, Jat PS, Collinge J. Highly infectious prions are not directly neurotoxic. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900920 DOI: 10.1073/Pnas.2007406117  0.374
2020 Thomas DX, Bajaj S, McRae-McKee K, Hadjichrysanthou C, Anderson RM, Collinge J. Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer's disease neuropathology. Scientific Reports. 10: 14579. PMID 32883971 DOI: 10.1038/S41598-020-71305-2  0.398
2020 Norsworthy PJ, Thompson AGB, Mok TH, Guntoro F, Dabin LC, Nihat A, Paterson RW, Schott JM, Collinge J, Mead S, Viré EA. A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis. Nature Communications. 11: 3960. PMID 32769986 DOI: 10.1038/S41467-020-17655-X  0.318
2020 Hosszu LLP, Conners R, Sangar D, Batchelor M, Sawyer EB, Fisher S, Cliff MJ, Hounslow AM, McAuley K, Leo Brady R, Jackson GS, Bieschke J, Waltho JP, Collinge J. Structural effects of the highly protective V127 polymorphism on human prion protein. Communications Biology. 3: 402. PMID 32728168 DOI: 10.1038/s42003-020-01126-6  0.302
2020 Asante EA, Linehan JM, Tomlinson A, Jakubcova T, Hamdan S, Grimshaw A, Smidak M, Jeelani A, Nihat A, Mead S, Brandner S, Wadsworth JDF, Collinge J. Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS. Plos Biology. 18: e3000725. PMID 32516343 DOI: 10.1371/Journal.Pbio.3000725  0.452
2019 Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, et al. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica. PMID 31853635 DOI: 10.1007/S00401-019-02114-9  0.424
2019 Katrak SM, Pauranik A, Desai SB, Mead S, Beck J, Brandner S, Collinge J. Familial Creutzfeldt-Jakob Disease in an Indian Kindred. Annals of Indian Academy of Neurology. 22: 458-461. PMID 31736569 DOI: 10.4103/Aian.Aian_214_19  0.442
2019 Canas LS, Sudre CH, De Vita E, Nihat A, Mok TH, Slattery CF, Paterson RW, Foulkes AJM, Hyare H, Cardoso MJ, Thornton J, Schott JM, Barkhof F, Collinge J, Ourselin S, et al. Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process. Neuroimage. Clinical. 24: 102051. PMID 31734530 DOI: 10.1016/J.Nicl.2019.102051  0.472
2019 Mead S, Lloyd S, Collinge J. Genetic Factors in Mammalian Prion Diseases. Annual Review of Genetics. PMID 31537104 DOI: 10.1146/Annurev-Genet-120213-092352  0.514
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Collinge J, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.742
2019 Koriath C, Lashley T, Taylor W, Druyeh R, Dimitriadis A, Denning N, Williams J, Warren JD, Fox NC, Schott JM, Rowe JB, Collinge J, Rohrer JD, Mead S. ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 277-280. PMID 30949567 DOI: 10.1016/J.Dadm.2019.01.010  0.376
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Collinge J, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.759
2019 Rudge P, Jaunmuktane Z, Hyare H, Ellis M, Koltzenburg M, Collinge J, Brandner S, Mead S. Early neurophysiological biomarkers and spinal cord pathology in inherited prion disease. Brain : a Journal of Neurology. PMID 30698738 DOI: 10.1093/Brain/Awy358  0.363
2019 Terry C, Harniman RL, Sells J, Wenborn A, Joiner S, Saibil HR, Miles MJ, Collinge J, Wadsworth JDF. Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro. Scientific Reports. 9: 376. PMID 30675000 DOI: 10.1038/S41598-018-36700-W  0.38
2018 Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone. Nature. PMID 30546139 DOI: 10.1038/S41586-018-0790-Y  0.407
2018 Clayton EL, Milioto C, Muralidharan B, Norona FE, Edgar JR, Soriano A, Jafar-Nejad P, Rigo F, Collinge J, Isaacs AM. Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown. Brain : a Journal of Neurology. 141: 3428-3442. PMID 30496365 DOI: 10.1093/Brain/Awy284  0.344
2018 Ford L, Rudge P, Robinson K, Collinge J, Gorham M, Mead S. The most problematic symptoms of prion disease - an analysis of carer experiences. International Psychogeriatrics. 1-10. PMID 30353798 DOI: 10.1017/S1041610218001588  0.41
2018 Mok TH, Koriath C, Jaunmuktane Z, Campbell T, Joiner S, Wadsworth JDF, Hosszu LLP, Brandner S, Parvez A, Truelsen TC, Lund EL, Saha R, Collinge J, Mead S. Evaluating the causality of novel sequence variants in the prion protein gene by example. Neurobiology of Aging. PMID 29861043 DOI: 10.1016/J.Neurobiolaging.2018.05.011  0.431
2018 Thompson AGB, Luk C, Heslegrave AJ, Zetterberg H, Mead SH, Collinge J, Jackson GS. Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29487167 DOI: 10.1136/Jnnp-2017-317793  0.39
2018 Joiner S, Asante EA, Linehan JM, Brock L, Brandner S, Bellworthy SJ, Simmons MM, Hope J, Collinge J, Wadsworth JDF. Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein. Journal of the Neurological Sciences. 386: 4-11. PMID 29406965 DOI: 10.1016/J.Jns.2017.12.038  0.404
2018 Purro SA, Nicoll AJ, Collinge J. Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers. Biological Psychiatry. 83: 358-368. PMID 29331212 DOI: 10.1016/J.Biopsych.2017.11.020  0.41
2018 Caine D, Nihat A, Crabb P, Rudge P, Cipolotti L, Collinge J, Mead S. The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature. Plos One. 13: e0190818. PMID 29304167 DOI: 10.1371/Journal.Pone.0190818  0.34
2017 Rudge P, Hyare H, Green A, Collinge J, Mead S. Imaging and CSF analyses effectively distinguish CJD from its mimics. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29142140 DOI: 10.1136/Jnnp-2017-316853  0.346
2017 Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J. Soluble Aβ aggregates can inhibit prion propagation. Open Biology. 7. PMID 29142106 DOI: 10.1098/Rsob.170158  0.411
2017 Rostgaard N, Roos P, Budtz-Jørgensen E, Johannsen P, Waldemar G, Nørremølle A, Lindquist SG, Gydesen S, Brown JM, Collinge J, Isaacs AM, Nielsen TT, Nielsen JE. TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3). Neurobiology of Aging. PMID 28888721 DOI: 10.1016/J.Neurobiolaging.2017.06.026  0.394
2017 Wadsworth JDF, Adamson G, Joiner S, Brock L, Powell C, Linehan JM, Beck JA, Brandner S, Mead S, Collinge J. Methods for Molecular Diagnosis of Human Prion Disease. Methods in Molecular Biology (Clifton, N.J.). 1658: 311-346. PMID 28861799 DOI: 10.1007/978-1-4939-7244-9_22  0.438
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Collinge J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.75
2017 Kenny J, Woollacott I, Koriath C, Hosszu L, Adamson G, Rudge P, Rossor MN, Collinge J, Rohrer JD, Mead S. A novel prion protein variant in a patient with semantic dementia. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 28572272 DOI: 10.1136/Jnnp-2017-315577  0.477
2017 Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell CJ, Cuello AC, Collinge J, Rowan MJ. Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies. Neuropharmacology. PMID 28390893 DOI: 10.1016/J.Neuropharm.2017.03.036  0.345
2017 Whitfield J, Pako W, Collinge J, Alpers MP. Cultural factors that affected the spatial and temporal epidemiology of kuru Royal Society Open Science. 4: 160789-160789. PMID 28280581 DOI: 10.1098/Rsos.160789  0.307
2017 Mok T, Jaunmuktane Z, Joiner S, Campbell T, Morgan C, Wakerley B, Golestani F, Rudge P, Mead S, Jäger HR, Wadsworth JD, Brandner S, Collinge J. Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129. The New England Journal of Medicine. 376: 292-294. PMID 28099827 DOI: 10.1056/Nejmc1610003  0.487
2017 Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Overgaard Larsen J, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, ... Collinge J, et al. Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation. Human Molecular Genetics. PMID 28093491 DOI: 10.1093/Hmg/Ddx003  0.347
2017 Qiang W, Yau WM, Lu JX, Collinge J, Tycko R. Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes. Nature. PMID 28052060 DOI: 10.1038/Nature20814  0.379
2017 De Vita E, Ridgway GR, White MJ, Porter MC, Caine D, Rudge P, Collinge J, Yousry TA, Jager HR, Mead S, Thornton JS, Hyare H. Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study. Neuroimage. Clinical. 13: 89-96. PMID 27942451 DOI: 10.1016/J.Nicl.2016.10.021  0.421
2016 Collinge J. Mammalian prions and their wider relevance in neurodegenerative diseases. Nature. 539: 217-226. PMID 27830781 DOI: 10.1038/Nature20415  0.462
2016 Luk C, Jones S, Thomas C, Fox NC, Mok TH, Mead S, Collinge J, Jackson GS. Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine. Jama Neurology. PMID 27699415 DOI: 10.1001/Jamaneurol.2016.3733  0.429
2016 Franko E, Wehner T, Joly O, Lowe J, Porter MC, Kenny J, Thompson A, Rudge P, Collinge J, Mead S. Quantitative EEG parameters correlate with the progression of human prion diseases. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27413165 DOI: 10.1136/Jnnp-2016-313501  0.458
2016 Terry C, Wenborn A, Gros N, Sells J, Joiner S, Hosszu LL, Tattum MH, Panico S, Clare DK, Collinge J, Saibil HR, Wadsworth JD. Ex vivo mammalian prions are formed of paired double helical prion protein fibrils. Open Biology. 6. PMID 27249641 DOI: 10.1098/Rsob.160035  0.354
2016 Balendra R, Uphill J, Collinson C, Druyeh R, Adamson G, Hummerich H, Zerr I, Gambetti P, Collinge J, Mead S. Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study. Bmc Medical Genetics. 17: 28. PMID 27055460 DOI: 10.1186/S12881-016-0278-2  0.507
2016 Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Yong KX, Lehmann M, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Murray ME, Khan QU, Petersen RC, Dickson DW, ... ... Collinge J, et al. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26993346 DOI: 10.1016/J.Jalz.2016.01.010  0.536
2016 Mead S, Burnell M, Lowe J, Thompson A, Lukic A, Porter MC, Carswell C, Kaski D, Kenny J, Mok TH, Bjurstrom N, Franko E, Gorham M, Druyeh R, Wadsworth JD, ... ... Collinge J, et al. Clinical Trial Simulations Based on Genetic Stratification and the Natural History of a Functional Outcome Measure in Creutzfeldt-Jakob Disease. Jama Neurology. PMID 26902324 DOI: 10.1001/Jamaneurol.2015.4885  0.465
2016 Koriath C, Adamson G, Druyeh R, Kenny J, Rossor M, Schott J, Collinge J, Fox N, Rohrer J, Mead S. Probing Ftd Genetics With Next-Generation Sequencing Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-315106.61  0.351
2016 Nihat A, Mok TH, Collinge J, Mead S. Assessing Cerebellar Function In Prion Disease Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-315106.222  0.38
2016 Mok TH, Koriath C, Campbell T, Saha R, Truelsen TC, Parvez A, Collinge J, Mead S. Estimating Causality Of The Novel Prion Protein Gene Variant T201S Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-315106.220  0.362
2016 Koriath C, Adamson G, Druyeh R, Kenny J, Collinge J, Wild E, Houlden H, Gaskin M, Mead S, Tabrizi S. J9 Probing huntington’s disease phenocopy syndromes with next-generation sequencing Journal of Neurology, Neurosurgery & Psychiatry. 87: A78.2-A78. DOI: 10.1136/Jnnp-2016-314597.221  0.391
2015 McKinnon C, Goold R, Andre R, Devoy A, Ortega Z, Moonga J, Linehan JM, Brandner S, Lucas JJ, Collinge J, Tabrizi SJ. Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta Neuropathologica. PMID 26646779 DOI: 10.1007/S00401-015-1508-Y  0.422
2015 Sawyer EB, Edgeworth JA, Thomas C, Collinge J, Jackson GS. Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease. Scientific Reports. 5: 17742. PMID 26631638 DOI: 10.1038/Srep17742  0.416
2015 Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, ... ... Collinge J, et al. A systematic investigation of production of synthetic prions from recombinant prion protein. Open Biology. 5. PMID 26631378 DOI: 10.1098/Rsob.150165  0.344
2015 Eisenmenger L, Porter MC, Carswell CJ, Thompson A, Mead S, Rudge P, Collinge J, Brandner S, Jäger HR, Hyare H. Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation. Jama Neurology. 1-9. PMID 26569479 DOI: 10.1001/Jamaneurol.2015.3159  0.374
2015 Clayton EL, Mizielinska S, Edgar JR, Nielsen TT, Marshall S, Norona FE, Robbins M, Damirji H, Holm IE, Johannsen P, Nielsen JE, Asante EA, Collinge J, Isaacs AM. Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology. Acta Neuropathologica. 130: 511-23. PMID 26358247 DOI: 10.1007/S00401-015-1475-3  0.394
2015 Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S. Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy. Nature. 525: 247-50. PMID 26354483 DOI: 10.1038/Nature15369  0.466
2015 Rudge P, Jaunmuktane Z, Adlard P, Bjurstrom N, Caine D, Lowe J, Norsworthy P, Hummerich H, Druyeh R, Wadsworth JD, Brandner S, Hyare H, Mead S, Collinge J. Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years. Brain : a Journal of Neurology. 138: 3386-99. PMID 26268531 DOI: 10.1093/Brain/Awv235  0.429
2015 Hudson G, Uphill J, Hummerich H, Blevins J, Gambetti P, Zerr I, Collinge J, Mead S, Chinnery PF. Inherited mtDNA variations are not strong risk factors in human prion disease. Neurobiology of Aging. 36: 2908.e1-3. PMID 26239179 DOI: 10.1016/J.Neurobiolaging.2015.07.005  0.375
2015 Asante EA, Grimshaw A, Smidak M, Jakubcova T, Tomlinson A, Jeelani A, Hamdan S, Powell C, Joiner S, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS. Plos Pathogens. 11: e1004953. PMID 26135918 DOI: 10.1371/Journal.Ppat.1004953  0.404
2015 Asante EA, Smidak M, Grimshaw A, Houghton R, Tomlinson A, Jeelani A, Jakubcova T, Hamdan S, Richard-Londt A, Linehan JM, Brandner S, Alpers M, Whitfield J, Mead S, Wadsworth JD, ... Collinge J, et al. A naturally occurring variant of the human prion protein completely prevents prion disease. Nature. 522: 478-81. PMID 26061765 DOI: 10.1038/Nature14510  0.464
2015 Caine D, Tinelli RJ, Hyare H, De Vita E, Lowe J, Lukic A, Thompson A, Porter MC, Cipolotti L, Rudge P, Collinge J, Mead S. The cognitive profile of prion disease: a prospective clinical and imaging study. Annals of Clinical and Translational Neurology. 2: 548-58. PMID 26000326 DOI: 10.1002/Acn3.195  0.443
2015 Risse E, Nicoll AJ, Taylor WA, Wright D, Badoni M, Yang X, Farrow MA, Collinge J. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. The Journal of Biological Chemistry. 290: 17020-8. PMID 25995455 DOI: 10.1074/Jbc.M115.637124  0.366
2015 Wenborn A, Terry C, Gros N, Joiner S, D'Castro L, Panico S, Sells J, Cronier S, Linehan JM, Brandner S, Saibil HR, Collinge J, Wadsworth JD. A novel and rapid method for obtaining high titre intact prion strains from mammalian brain. Scientific Reports. 5: 10062. PMID 25950908 DOI: 10.1038/Srep10062  0.328
2015 Thompson AG, Uphill J, Lowe J, Porter MC, Lukic A, Carswell C, Rudge P, MacKay A, Collinge J, Mead S. Genome-wide association study of behavioural and psychiatric features in human prion disease. Translational Psychiatry. 5: e552. PMID 25897833 DOI: 10.1038/Tp.2015.42  0.483
2015 Hyare H, So PW, Brandner S, Collinge J, Parkes HG. MRI detection of prion protein plaques in variant Creutzfeldt-Jakob disease. Neurology. 84: 1498-9. PMID 25846996 DOI: 10.1212/Wnl.0000000000000304  0.399
2015 Lukic A, Uphill J, Brown CA, Beck J, Poulter M, Campbell T, Adamson G, Hummerich H, Whitfield J, Ponto C, Zerr I, Lloyd SE, Collinge J, Mead S. Rare structural genetic variation in human prion diseases. Neurobiology of Aging. 36: 2004.e1-8. PMID 25726360 DOI: 10.1136/Jnnp-2016-315106.117  0.505
2015 Mirabile I, Jat PS, Brandner S, Collinge J. Identification of clinical target areas in the brainstem of prion-infected mice. Neuropathology and Applied Neurobiology. 41: 613-30. PMID 25311251 DOI: 10.1111/Nan.12189  0.302
2015 Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Lehmann M, Taner N, Graff-Radford N, Boeve B, Murray ME, Qurat ul Ain K, Petersen RC, Dickson DW, Knopman DS, ... ... Collinge J, et al. F2-03-04: Genetic risk factors for posterior cortical atrophy Alzheimer's & Dementia. 11: P168-P169. DOI: 10.1016/J.Jalz.2015.07.119  0.381
2014 Minikel EV, Zerr I, Collins SJ, Ponto C, Boyd A, Klug G, Karch A, Kenny J, Collinge J, Takada LT, Forner S, Fong JC, Mead S, Geschwind MD. Ascertainment bias causes false signal of anticipation in genetic prion disease. American Journal of Human Genetics. 95: 371-82. PMID 25279981 DOI: 10.1016/J.Ajhg.2014.09.003  0.422
2014 Slattery CF, Beck JA, Harper L, Adamson G, Abdi Z, Uphill J, Campbell T, Druyeh R, Mahoney CJ, Rohrer JD, Kenny J, Lowe J, Leung KK, Barnes J, Clegg SL, ... ... Collinge J, et al. R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 602-608.e4. PMID 25160042 DOI: 10.1016/J.Jalz.2014.05.1751  0.636
2014 Jackson GS, Burk-Rafel J, Mead S, Collinge J. Blood test for variant Creutzfeldt-Jakob disease--reply. Jama Neurology. 71: 1054-5. PMID 25111211 DOI: 10.1001/Jamaneurol.2014.1539  0.38
2014 Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, et al. N-terminal domain of prion protein directs its oligomeric association. The Journal of Biological Chemistry. 289: 25497-508. PMID 25074940 DOI: 10.1074/Jbc.M114.566588  0.382
2014 Sandberg MK, Al-Doujaily H, Sharps B, De Oliveira MW, Schmidt C, Richard-Londt A, Lyall S, Linehan JM, Brandner S, Wadsworth JD, Clarke AR, Collinge J. Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked. Nature Communications. 5: 4347. PMID 25005024 DOI: 10.1038/Ncomms5347  0.317
2014 Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, ... ... Collinge J, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology. 13: 686-99. PMID 24943344 DOI: 10.1016/S1474-4422(14)70065-1  0.586
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Collinge J, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661  0.68
2014 Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC. Identification of a gene regulatory network associated with prion replication. The Embo Journal. 33: 1527-47. PMID 24843046 DOI: 10.15252/Embj.201387150  0.371
2014 Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE. In vitro screen of prion disease susceptibility genes using the scrapie cell assay. Human Molecular Genetics. 23: 5102-8. PMID 24833721 DOI: 10.1093/Hmg/Ddu233  0.453
2014 Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6140-5. PMID 24790184 DOI: 10.1523/Jneurosci.3526-13.2014  0.381
2014 Owen J, Beck J, Campbell T, Adamson G, Gorham M, Thompson A, Smithson S, Rosser E, Rudge P, Collinge J, Mead S. Predictive testing for inherited prion disease: report of 22 years experience. European Journal of Human Genetics : Ejhg. 22: 1351-6. PMID 24713662 DOI: 10.1038/Ejhg.2014.42  0.357
2014 Grizenkova J, Akhtar S, Brandner S, Collinge J, Lloyd SE. Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. Bmc Neuroscience. 15: 44. PMID 24655482 DOI: 10.1186/1471-2202-15-44  0.439
2014 Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Schott JM, Mummery C, Chinnery PF, Mead S, Collinge J. Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study. Jama Neurology. 71: 421-8. PMID 24590363 DOI: 10.1001/Jamaneurol.2013.6001  0.388
2014 Thompson A, MacKay A, Rudge P, Lukic A, Porter MC, Lowe J, Collinge J, Mead S. Behavioral and psychiatric symptoms in prion disease. The American Journal of Psychiatry. 171: 265-74. PMID 24585329 DOI: 10.1176/Appi.Ajp.2013.12111460  0.373
2014 Mead S, Wadsworth JD, Porter MC, Linehan JM, Pietkiewicz W, Jackson GS, Brandner S, Collinge J. Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein. Jama Neurology. 71: 340-3. PMID 24445428 DOI: 10.1001/Jamaneurol.2013.5378  0.414
2014 Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Mead S, Collinge J. A highly specific blood test for vCJD. Blood. 123: 452-3. PMID 24434999 DOI: 10.1182/Blood-2013-11-539239  0.405
2014 Beck J, Pittman A, Adamson G, Campbell T, Kenny J, Houlden H, Rohrer JD, de Silva R, Shoai M, Uphill J, Poulter M, Hardy J, Mummery CJ, Warren JD, Schott JM, ... ... Collinge J, et al. Validation of next-generation sequencing technologies in genetic diagnosis of dementia. Neurobiology of Aging. 35: 261-5. PMID 23998997 DOI: 10.1016/J.Neurobiolaging.2013.07.017  0.464
2014 Porter M, De Vita E, Simpson I, Franko E, Bjurstrom N, Rudge P, Mead S, Collinge J, Thornton J, Hyare H. MULTI-PARAMETER MRI ANALYSIS IN THE NATIONAL PRION COHORT Journal of Neurology, Neurosurgery & Psychiatry. 85: e4.25-e4. DOI: 10.1136/Jnnp-2014-309236.120  0.322
2013 Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A. Creutzfeld-Jakob disease--reply. Jama Neurology. 70: 1589. PMID 24322520 DOI: 10.1001/Jamaneurol.2013.4777  0.446
2013 Reiniger L, Mirabile I, Lukic A, Wadsworth JD, Linehan JM, Groves M, Lowe J, Druyeh R, Rudge P, Collinge J, Mead S, Brandner S. Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases. Acta Neuropathologica Communications. 1: 8. PMID 24252267 DOI: 10.1186/2051-5960-1-8  0.453
2013 Mead S, Gandhi S, Beck J, Caine D, Gajulapalli D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, ... ... Collinge J, et al. A novel prion disease associated with diarrhea and autonomic neuropathy. The New England Journal of Medicine. 369: 1904-14. PMID 24224623 DOI: 10.1056/Nejmoa1214747  0.505
2013 Wadsworth JD, Joiner S, Linehan JM, Balkema-Buschmann A, Spiropoulos J, Simmons MM, Griffiths PC, Groschup MH, Hope J, Brandner S, Asante EA, Collinge J. Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein. Emerging Infectious Diseases. 19: 1731-9. PMID 24188521 DOI: 10.3201/Eid1911.121341  0.407
2013 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Collinge J, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802  0.685
2013 Asante EA, Linehan JM, Smidak M, Tomlinson A, Grimshaw A, Jeelani A, Jakubcova T, Hamdan S, Powell C, Brandner S, Wadsworth JD, Collinge J. Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. Plos Pathogens. 9: e1003643. PMID 24086135 DOI: 10.1371/Journal.Ppat.1003643  0.476
2013 Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity. Nature Communications. 4: 2416. PMID 24022506 DOI: 10.1038/Ncomms3416  0.396
2013 Klöhn PC, Castro-Seoane R, Collinge J. Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery? The Journal of Infection. 67: 359-68. PMID 23911964 DOI: 10.1016/J.Jinf.2013.07.024  0.359
2013 Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, ... ... Collinge J, et al. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. Acta Neuropathologica. 126: 401-9. PMID 23818065 DOI: 10.1007/S00401-013-1147-0  0.598
2013 Goold R, McKinnon C, Rabbanian S, Collinge J, Schiavo G, Tabrizi SJ. Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane. Journal of Cell Science. 126: 3552-62. PMID 23813960 DOI: 10.1242/Jcs.120477  0.351
2013 Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A. Autoantibodies in sporadic Creutzfeldt-Jakob disease. Jama Neurology. 70: 919-22. PMID 23699783 DOI: 10.1001/Jamaneurol.2013.2077  0.403
2013 Thompson AG, Lowe J, Fox Z, Lukic A, Porter MC, Ford L, Gorham M, Gopalakrishnan GS, Rudge P, Walker AS, Collinge J, Mead S. The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies. Brain : a Journal of Neurology. 136: 1116-27. PMID 23550114 DOI: 10.1093/Brain/Awt048  0.357
2013 De Vita E, Ridgway GR, Scahill RI, Caine D, Rudge P, Yousry TA, Mead S, Collinge J, Jäger HR, Thornton JS, Hyare H. Multiparameter MR imaging in the 6-OPRI variant of inherited prion disease. Ajnr. American Journal of Neuroradiology. 34: 1723-30. PMID 23538406 DOI: 10.3174/Ajnr.A3504  0.397
2013 Lloyd SE, Mead S, Collinge J. Genetics of prion diseases. Current Opinion in Genetics & Development. 23: 345-51. PMID 23518043 DOI: 10.1016/J.Gde.2013.02.012  0.494
2013 Beck J, Poulter M, Hensman D, Rohrer JD, Mahoney CJ, Adamson G, Campbell T, Uphill J, Borg A, Fratta P, Orrell RW, Malaspina A, Rowe J, Brown J, Hodges J, ... ... Collinge J, et al. Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. American Journal of Human Genetics. 92: 345-53. PMID 23434116 DOI: 10.1016/J.Ajhg.2013.01.011  0.542
2013 Akhtar S, Grizenkova J, Wenborn A, Hummerich H, Fernandez de Marco M, Brandner S, Collinge J, Lloyd SE. Sod1 deficiency reduces incubation time in mouse models of prion disease. Plos One. 8: e54454. PMID 23349894 DOI: 10.1371/Journal.Pone.0054454  0.432
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851  0.781
2013 Jackson GS, Mead S, Collinge J. Developing early diagnostics for prion diseases Neurodegenerative Disease Management. 3: 53-60. DOI: 10.2217/Nmt.12.76  0.448
2013 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Collinge J, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 45: 712-712. DOI: 10.1038/Ng0613-712A  0.767
2012 Carswell C, Thompson A, Lukic A, Stevens J, Rudge P, Mead S, Collinge J, Hyare H. MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease. Bmc Neurology. 12: 153. PMID 23216655 DOI: 10.1186/1471-2377-12-153  0.366
2012 Carswell C, Rañopa M, Pal S, Macfarlane R, Siddique D, Thomas D, Webb T, Wroe S, Walker S, Darbyshire J, Collinge J, Mead S, Rudge P. Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1. Dementia and Geriatric Cognitive Disorders Extra. 2: 286-97. PMID 22962552 DOI: 10.1159/000339730  0.303
2012 Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 13722-7. PMID 22869728 DOI: 10.1073/Pnas.1208917109  0.428
2012 Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain : a Journal of Neurology. 135: 819-32. PMID 22366797 DOI: 10.1093/Brain/Aws006  0.352
2012 Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, Yeatman T, Warrington EK, Schott JM, Fox NC, Rossor MN, Hardy J, Collinge J, Revesz T, Mead S, et al. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain : a Journal of Neurology. 135: 736-50. PMID 22366791 DOI: 10.1093/Brain/Awr361  0.506
2012 Castro-Seoane R, Hummerich H, Sweeting T, Tattum MH, Linehan JM, Fernandez de Marco M, Brandner S, Collinge J, Klöhn PC. Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection. Plos Pathogens. 8: e1002538. PMID 22359509 DOI: 10.1371/Journal.Ppat.1002538  0.31
2012 Collinge J. Cell biology. The risk of prion zoonoses. Science (New York, N.Y.). 335: 411-3. PMID 22282797 DOI: 10.1126/Science.1218167  0.373
2012 Klöhn PC, Farmer M, Linehan JM, O'Malley C, Fernandez de Marco M, Taylor W, Farrow M, Khalili-Shirazi A, Brandner S, Collinge J. PrP antibodies do not trigger mouse hippocampal neuron apoptosis. Science (New York, N.Y.). 335: 52. PMID 22223800 DOI: 10.1126/Science.1215579  0.397
2012 Mead S, Uphill J, Beck J, Poulter M, Campbell T, Lowe J, Adamson G, Hummerich H, Klopp N, Rückert IM, Wichmann HE, Azazi D, Plagnol V, Pako WH, Whitfield J, ... ... Collinge J, et al. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. Human Molecular Genetics. 21: 1897-906. PMID 22210626 DOI: 10.1093/Hmg/Ddr607  0.48
2012 Beck J, Collinge J, Mead S. Prion protein gene M232R variation is probably an uncommon polymorphism rather than a pathogenic mutation. Brain : a Journal of Neurology. 135: e209; author reply e. PMID 22108575 DOI: 10.1093/Brain/Awr294  0.439
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Collinge J, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824  0.785
2012 Alner K, Hyare H, Mead S, Rudge P, Wroe S, Rohrer JD, Ridgway GR, Ourselin S, Clarkson M, Hunt H, Fox NC, Webb T, Collinge J, Cipolotti L. Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 109-14. PMID 21849340 DOI: 10.1136/Jnnp-2011-300167  0.373
2012 Hyare H, Ramlackhansingh A, Gelosa G, Edison P, Rudge P, Brandner S, Brooks DJ, Collinge J, Mead S. 11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 340-1. PMID 21478204 DOI: 10.1136/Jnnp.2010.233692  0.398
2012 McNaughton D, Knight W, Guerreiro R, Ryan N, Lowe J, Poulter M, Nicholl DJ, Hardy J, Revesz T, Lowe J, Rossor M, Collinge J, Mead S. Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiology of Aging. 33: 426.e13-21. PMID 21193246 DOI: 10.1016/J.Neurobiolaging.2010.10.010  0.683
2012 Mahoney CJ, Rohrer JD, Beck J, Shakespeare T, Yeatman T, Schot JM, Fox N, Rossor MN, Hardy J, Collinge J, Mead S, Warren JD. The neuroimaging phenotype of frontotemporal dementia with the C9ORF72 hexanucletoide repeat expansion Alzheimers & Dementia. 8: 8. DOI: 10.1016/J.Jalz.2012.05.025  0.452
2012 Wadsworth JDF, Collinge J. Molecular Basis of Prion Diseases Basic Neurochemistry. 872-885. DOI: 10.1016/B978-0-12-374947-5.00050-X  0.315
2011 Akhtar S, Wenborn A, Brandner S, Collinge J, Lloyd SE. Sex effects in mouse prion disease incubation time. Plos One. 6: e28741. PMID 22174884 DOI: 10.1371/Journal.Pone.0028741  0.398
2011 Mead S, Ranopa M, Gopalakrishnan GS, Thompson AG, Rudge P, Wroe S, Kennedy A, Hudson F, MacKay A, Darbyshire JH, Collinge J, Walker AS. PRION-1 scales analysis supports use of functional outcome measures in prion disease. Neurology. 77: 1674-83. PMID 22013183 DOI: 10.1212/Wnl.0B013E3182364890  0.354
2011 Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R, Ivanov D, Pahwa JS, Moskvina V, Dowzell K, Thomas C, Stretton A, Lovestone S, ... ... Collinge J, et al. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 764-71. PMID 21812096 DOI: 10.1002/Ajmg.B.31216  0.639
2011 Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ. Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. The Embo Journal. 30: 3065-77. PMID 21743439 DOI: 10.1038/Emboj.2011.224  0.367
2011 Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nature Communications. 2: 336. PMID 21654636 DOI: 10.1038/Ncomms1341  0.347
2011 Kaski DN, Pennington C, Beck J, Poulter M, Uphill J, Bishop MT, Linehan JM, O'Malley C, Wadsworth JD, Joiner S, Knight RS, Ironside JW, Brandner S, Collinge J, Mead S. Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors. Brain : a Journal of Neurology. 134: 1829-38. PMID 21616973 DOI: 10.1093/Brain/Awr079  0.506
2011 Lloyd S, Mead S, Collinge J. Genetics of prion disease. Topics in Current Chemistry. 305: 1-22. PMID 21528440 DOI: 10.1007/128_2011_157  0.514
2011 Goold R, Rabbanian S, Sutton L, Andre R, Arora P, Moonga J, Clarke AR, Schiavo G, Jat P, Collinge J, Tabrizi SJ. Rapid cell-surface prion protein conversion revealed using a novel cell system. Nature Communications. 2: 281. PMID 21505437 DOI: 10.1038/Ncomms1282  0.36
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Collinge J, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803  0.74
2011 Rohrer JD, Warren JD, Reiman D, Uphill J, Beck J, Collinge J, Rossor MN, Isaacs AM, Mead S. A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes. Journal of Neurology. 258: 1494-6. PMID 21387114 DOI: 10.1007/S00415-011-5966-4  0.434
2011 Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature. 470: 540-2. PMID 21350487 DOI: 10.1038/Nature09768  0.343
2011 Edgeworth JA, Farmer M, Sicilia A, Tavares P, Beck J, Campbell T, Lowe J, Mead S, Rudge P, Collinge J, Jackson GS. Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay. Lancet. 377: 487-93. PMID 21295339 DOI: 10.1016/S0140-6736(10)62308-2  0.359
2011 Wadsworth JD, Dalmau-Mena I, Joiner S, Linehan JM, O'Malley C, Powell C, Brandner S, Asante EA, Ironside JW, Hilton DA, Collinge J. Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study. The Journal of Pathology. 223: 511-8. PMID 21294124 DOI: 10.1002/Path.2821  0.323
2011 Lukic A, Mead S, Rudge P, Collinge J. Comment on validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. Annals of Neurology. 69: 212; author reply 21. PMID 21280094 DOI: 10.1002/Ana.22273  0.431
2011 Ratté S, Vreugdenhil M, Boult JK, Patel A, Asante EA, Collinge J, Jefferys JG. Threshold for epileptiform activity is elevated in prion knockout mice. Neuroscience. 179: 56-61. PMID 21277354 DOI: 10.1016/J.Neuroscience.2011.01.053  0.622
2011 Edgeworth JA, Sicilia A, Linehan J, Brandner S, Jackson GS, Collinge J. A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay. The Journal of General Virology. 92: 718-26. PMID 21084494 DOI: 10.1099/Vir.0.027201-0  0.327
2011 Stevens JC, Beck J, Lukic A, Ryan N, Abbs S, Collinge J, Fox NC, Mead S. Familial Alzheimer's disease and inherited prion disease in the UK are poorly ascertained. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 1054-7. PMID 20802216 DOI: 10.1136/Jnnp.2009.199653  0.445
2011 Wadsworth JD, Collinge J. Molecular pathology of human prion disease. Acta Neuropathologica. 121: 69-77. PMID 20694796 DOI: 10.1007/S00401-010-0735-5  0.406
2011 Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S. Tau, prions and Aβ: the triad of neurodegeneration. Acta Neuropathologica. 121: 5-20. PMID 20473510 DOI: 10.1007/S00401-010-0691-0  0.45
2011 Rollinson S, Rohrer JD, van der Zee J, Sleegers K, Mead S, Engelborghs S, Collinge J, De Deyn PP, Mann DM, Van Broeckhoven C, Pickering-Brown SM. No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration. Neurobiology of Aging. 32: 754-5. PMID 19446372 DOI: 10.1016/J.Neurobiolaging.2009.04.009  0.323
2011 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Collinge J, et al. Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease Plos One. 6. DOI: 10.1371/annotation/a0bb886d-d345-4a20-a82e-adce9b047798  0.714
2011 Thompson A, Mahoney C, Ryan N, Bajaj N, Lukic A, Carswell C, Hyare H, Gopalakrishnan G, Mummery C, Collinge J, Rudge P, Fox N, Mead S. Prion disease masquerading as Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2196  0.473
2010 D'Castro L, Wenborn A, Gros N, Joiner S, Cronier S, Collinge J, Wadsworth JD. Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid. Plos One. 5: e15679. PMID 21187933 DOI: 10.1371/Journal.Pone.0015679  0.411
2010 Grizenkova J, Akhtar S, Collinge J, Lloyd SE. The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse. Plos One. 5: e15019. PMID 21151910 DOI: 10.1371/Journal.Pone.0015019  0.509
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Collinge J, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/Journal.Pone.0013950  0.761
2010 O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14411-9. PMID 20980598 DOI: 10.1523/Jneurosci.3537-10.2010  0.333
2010 Siddique D, Hyare H, Wroe S, Webb T, Macfarlane R, Rudge P, Collinge J, Powell C, Brandner S, So PW, Walker S, Mead S, Yousry T, Thornton JS. Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases. Brain : a Journal of Neurology. 133: 3058-68. PMID 20881162 DOI: 10.1093/Brain/Awq243  0.333
2010 Wadsworth JD, Asante EA, Collinge J. Review: contribution of transgenic models to understanding human prion disease. Neuropathology and Applied Neurobiology. 36: 576-97. PMID 20880036 DOI: 10.1111/J.1365-2990.2010.01129.X  0.447
2010 Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quarterman E, Ibarra AA, Wright C, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J. Pharmacological chaperone for the structured domain of human prion protein. Proceedings of the National Academy of Sciences of the United States of America. 107: 17610-5. PMID 20876144 DOI: 10.1073/Pnas.1009062107  0.356
2010 Hosszu LL, Tattum MH, Jones S, Trevitt CR, Wells MA, Waltho JP, Collinge J, Jackson GS, Clarke AR. The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the PrP(Sc)-like form. Biochemistry. 49: 8729-38. PMID 20718410 DOI: 10.1021/Bi100572J  0.384
2010 Lukic A, Beck J, Joiner S, Fearnley J, Sturman S, Brandner S, Wadsworth JD, Collinge J, Mead S. Heterozygosity at polymorphic codon 219 in variant creutzfeldt-jakob disease. Archives of Neurology. 67: 1021-3. PMID 20697057 DOI: 10.1001/Archneurol.2010.184  0.457
2010 Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. The Journal of General Virology. 91: 2651-7. PMID 20610667 DOI: 10.1099/Vir.0.024380-0  0.421
2010 Beck JA, Poulter M, Campbell TA, Adamson G, Uphill JB, Guerreiro R, Jackson GS, Stevens JC, Manji H, Collinge J, Mead S. PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit. Human Mutation. 31: E1551-63. PMID 20583301 DOI: 10.1002/Humu.21281  0.629
2010 Tattum MH, Jones S, Pal S, Khalili-Shirazi A, Collinge J, Jackson GS. A highly sensitive immunoassay for the detection of prion-infected material in whole human blood without the use of proteinase K. Transfusion. 50: 2619-27. PMID 20561299 DOI: 10.1111/J.1537-2995.2010.02731.X  0.328
2010 Collinge J. Medicine. Prion strain mutation and selection. Science (New York, N.Y.). 328: 1111-2. PMID 20508117 DOI: 10.1126/Science.1190815  0.417
2010 Chia R, Tattum MH, Jones S, Collinge J, Fisher EM, Jackson GS. Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis. Plos One. 5: e10627. PMID 20498711 DOI: 10.1371/Journal.Pone.0010627  0.437
2010 Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, ... ... Collinge J, et al. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathologica. 120: 33-41. PMID 20490813 DOI: 10.1007/S00401-010-0698-6  0.336
2010 Urwin H, Authier A, Nielsen JE, Metcalf D, Powell C, Froud K, Malcolm DS, Holm I, Johannsen P, Brown J, Fisher EM, van der Zee J, Bruyland M, Van Broeckhoven C, ... Collinge J, et al. Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations. Human Molecular Genetics. 19: 2228-38. PMID 20223751 DOI: 10.1093/Hmg/Ddq100  0.347
2010 Guerreiro RJ, Beck J, Gibbs JR, Santana I, Rossor MN, Schott JM, Nalls MA, Ribeiro H, Santiago B, Fox NC, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J. Genetic variability in CLU and its association with Alzheimer's disease. Plos One. 5: e9510. PMID 20209083 DOI: 10.1371/Journal.Pone.0009510  0.72
2010 Tattum MH, Jones S, Pal S, Collinge J, Jackson GS. Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification. Transfusion. 50: 996-1002. PMID 20180925 DOI: 10.1111/J.1537-2995.2010.02595.X  0.318
2010 Hyare H, Wroe S, Siddique D, Webb T, Fox NC, Stevens J, Collinge J, Yousry T, Thornton JS. Brain-water diffusion coefficients reflect the severity of inherited prion disease. Neurology. 74: 658-65. PMID 20177119 DOI: 10.1212/Wnl.0B013E3181D0Cc47  0.404
2010 Lloyd SE, Maytham EG, Grizenkova J, Hummerich H, Collinge J. A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse. Neurogenetics. 11: 185-91. PMID 19795140 DOI: 10.1007/S10048-009-0219-8  0.458
2010 Carswell C, Khalili-Shirazi A, Brandner S, Martins S, Drynda R, Collinge J, Mead S, Clarke A. PAW35 Anti-prion protein monoclonal antibodies at low doses effectively treat prion disease in mice without side-effects Journal of Neurology, Neurosurgery & Psychiatry. 81: e33-e33. DOI: 10.1136/Jnnp.2010.226340.63  0.323
2010 Mead S, Linehan J, Beck J, Caine D, Gandhi S, Wadsworth JDF, Joiner S, Gallujipali D, Hyare H, Lees A, Holton J, Sandberg M, Revesz T, Carswell C, Warren JD, ... Collinge J, et al. PATU2 Novel truncation mutation of PRNP causes chronic diarrhoea, sensory neuropathy and autonomic failure associated with prion protein deposition in the cerebral blood vessels and small bowel Journal of Neurology, Neurosurgery & Psychiatry. 81: e24-e24. DOI: 10.1136/Jnnp.2010.226340.31  0.311
2010 Mead S, Hyare H, Collinge J, Rudge P. Variant or sporadic Creutzfeldt-Jakob disease? – Authors' reply The Lancet. 375: 889-890. DOI: 10.1016/S0140-6736(10)60379-0  0.443
2009 Kaski D, Mead S, Hyare H, Cooper S, Jampana R, Overell J, Knight R, Collinge J, Rudge P. Variant CJD in an individual heterozygous for PRNP codon 129. Lancet. 374: 2128. PMID 20109837 DOI: 10.1016/S0140-6736(09)61568-3  0.475
2009 Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Dujaily H, Hummerich H, Beck J, Mein CA, Verzilli C, Whittaker J, Alpers MP, Collinge J. A novel protective prion protein variant that colocalizes with kuru exposure. The New England Journal of Medicine. 361: 2056-65. PMID 19923577 DOI: 10.1056/Nejmoa0809716  0.417
2009 Rohrer JD, Beck J, Warren JD, King A, Al Sarraj S, Holton J, Revesz T, Collinge J, Mead S. Corticobasal syndrome associated with a novel 1048_1049insG progranulin mutation. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 1297-8. PMID 19864668 DOI: 10.1136/Jnnp.2008.169383  0.349
2009 Lloyd SE, Rossor M, Fox N, Mead S, Collinge J. HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q. Bmc Medical Genetics. 10: 90. PMID 19754925 DOI: 10.1186/1471-2350-10-90  0.471
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Collinge J, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440  0.754
2009 Lloyd SE, Grizenkova J, Pota H, Collinge J. Shadoo (Sprn) and prion disease incubation time in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 367-74. PMID 19513788 DOI: 10.1007/S00335-009-9194-5  0.457
2009 Hosszu LL, Trevitt CR, Jones S, Batchelor M, Scott DJ, Jackson GS, Collinge J, Waltho JP, Clarke AR. Conformational properties of beta-PrP. The Journal of Biological Chemistry. 284: 21981-90. PMID 19369250 DOI: 10.1074/Jbc.M809173200  0.304
2009 Hart T, Hosszu LL, Trevitt CR, Jackson GS, Waltho JP, Collinge J, Clarke AR. Folding kinetics of the human prion protein probed by temperature jump. Proceedings of the National Academy of Sciences of the United States of America. 106: 5651-6. PMID 19321423 DOI: 10.1073/Pnas.0811457106  0.323
2009 Collinge J, Gorham M, Hudson F, Kennedy A, Keogh G, Pal S, Rossor M, Rudge P, Siddique D, Spyer M, Thomas D, Walker S, Webb T, Wroe S, Darbyshire J. Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial. The Lancet. Neurology. 8: 334-44. PMID 19278902 DOI: 10.1016/S1474-4422(09)70049-3  0.433
2009 Tayebi M, Collinge J, Hawke S. Unswitched immunoglobulin M response prolongs mouse survival in prion disease. The Journal of General Virology. 90: 777-82. PMID 19218226 DOI: 10.1099/Vir.0.005041-0  0.376
2009 Asante EA, Gowland I, Grimshaw A, Linehan JM, Smidak M, Houghton R, Osiguwa O, Tomlinson A, Joiner S, Brandner S, Wadsworth JD, Collinge J. Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins. The Journal of General Virology. 90: 546-58. PMID 19218199 DOI: 10.1099/Vir.0.007930-0  0.457
2009 Rollinson S, Rizzu P, Sikkink S, Baker M, Halliwell N, Snowden J, Traynor BJ, Ruano D, Cairns N, Rohrer JD, Mead S, Collinge J, Rossor M, Akay E, Guerreiro R, et al. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiology of Aging. 30: 656-65. PMID 19217189 DOI: 10.1016/J.Neurobiolaging.2009.01.009  0.604
2009 Lloyd SE, Maytham EG, Pota H, Grizenkova J, Molou E, Uphill J, Hummerich H, Whitfield J, Alpers MP, Mead S, Collinge J. HECTD2 is associated with susceptibility to mouse and human prion disease. Plos Genetics. 5: e1000383. PMID 19214206 DOI: 10.1371/Journal.Pgen.1000383  0.501
2009 Webb T, Mead S, Beck J, Uphill J, Pal S, Hampson S, Wadsworth JD, Mena ID, O'Malley C, Wroe S, Schapira A, Brandner S, Collinge J. Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L). Neuropathology and Applied Neurobiology. 35: 427-32. PMID 19207267 DOI: 10.1111/J.1365-2990.2009.01012.X  0.383
2009 Antonyuk SV, Trevitt CR, Strange RW, Jackson GS, Sangar D, Batchelor M, Cooper S, Fraser C, Jones S, Georgiou T, Khalili-Shirazi A, Clarke AR, Hasnain SS, Collinge J. Crystal structure of human prion protein bound to a therapeutic antibody. Proceedings of the National Academy of Sciences of the United States of America. 106: 2554-8. PMID 19204296 DOI: 10.1073/Pnas.0809170106  0.374
2009 Edgeworth JA, Jackson GS, Clarke AR, Weissmann C, Collinge J. Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces. Proceedings of the National Academy of Sciences of the United States of America. 106: 3479-83. PMID 19204279 DOI: 10.1073/Pnas.0813342106  0.341
2009 Nicoll AJ, Collinge J. Preventing prion pathogenicity by targeting the cellular prion protein. Infectious Disorders Drug Targets. 9: 48-57. PMID 19200015 DOI: 10.2174/1871526510909010048  0.434
2009 Urwin H, Ghazi-Noori S, Collinge J, Isaacs A. The role of CHMP2B in frontotemporal dementia. Biochemical Society Transactions. 37: 208-12. PMID 19143633 DOI: 10.1042/Bst0370208  0.332
2009 Mead S, Poulter M, Uphill J, Beck J, Whitfield J, Webb TE, Campbell T, Adamson G, Deriziotis P, Tabrizi SJ, Hummerich H, Verzilli C, Alpers MP, Whittaker JC, Collinge J. Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. The Lancet. Neurology. 8: 57-66. PMID 19081515 DOI: 10.1016/S1474-4422(08)70265-5  0.476
2009 Webb TE, Whittaker J, Collinge J, Mead S. Age of onset and death in inherited prion disease are heritable. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 496-501. PMID 18729123 DOI: 10.1002/Ajmg.B.30844  0.494
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Collinge J, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156D  0.749
2009 Mead S, Rudge P, Hudson F, Walker S, Darbyshire J, Collinge J. Clinical trials and methodological problems in prion diseases - Authors' reply The Lancet Neurology. 8: 782-783. DOI: 10.1016/S1474-4422(09)70215-7  0.327
2009 Ryan N, McNaughton D, Knight W, Guerreiro R, Poulter M, Nicholl D, Hardy J, Rossor M, Collinge J, Mead S. Duplications of APP—but not PRNP—are a significant cause of early-onset dementia in a large UK referral series Alzheimers & Dementia. 5: 460. DOI: 10.1016/J.Jalz.2009.04.869  0.613
2008 Brandner S, Whitfield J, Boone K, Puwa A, O'Malley C, Linehan JM, Joiner S, Scaravilli F, Calder I, P Alpers M, Wadsworth JD, Collinge J. Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3755-63. PMID 18849292 DOI: 10.1098/Rstb.2008.0091  0.442
2008 Wadsworth JD, Joiner S, Linehan JM, Asante EA, Brandner S, Collinge J. Review. The origin of the prion agent of kuru: molecular and biological strain typing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3747-53. PMID 18849291 DOI: 10.1098/Rstb.2008.0069  0.443
2008 Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Beck J, Campbell T, Al-Dujaily H, Hummerich H, Alpers MP, Collinge J. Genetic susceptibility, evolution and the kuru epidemic. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3741-6. PMID 18849290 DOI: 10.1098/Rstb.2008.0087  0.368
2008 Collinge J, Whitfield J, McKintosh E, Frosh A, Mead S, Hill AF, Brandner S, Thomas D, Alpers MP. A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3725-39. PMID 18849289 DOI: 10.1098/Rstb.2008.0068  0.355
2008 Collinge J. Review. Lessons of kuru research: background to recent studies with some personal reflections. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3689-96. PMID 18849283 DOI: 10.1098/Rstb.2008.0121  0.389
2008 Collinge J, Alpers MP. Reminiscences and reflections on kuru, personal and scientific. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3613. PMID 18849244 DOI: 10.1098/Rstb.2008.0098  0.352
2008 Beck JA, Campbell TA, Adamson G, Poulter M, Uphill JB, Molou E, Collinge J, Mead S. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. Journal of Medical Genetics. 45: 813-7. PMID 18805828 DOI: 10.1136/Jmg.2008.061804  0.462
2008 Webb TE, Poulter M, Beck J, Uphill J, Adamson G, Campbell T, Linehan J, Powell C, Brandner S, Pal S, Siddique D, Wadsworth JD, Joiner S, Alner K, Petersen C, ... ... Collinge J, et al. Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series. Brain : a Journal of Neurology. 131: 2632-46. PMID 18757886 DOI: 10.1093/Brain/Awn202  0.435
2008 Webb TE, Pal S, Siddique D, Heaney DC, Linehan JM, Wadsworth JD, Joiner S, Beck J, Wroe SJ, Stevenson V, Brandner S, Mead S, Collinge J. First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation. Journal of Neuropathology and Experimental Neurology. 67: 838-41. PMID 18716560 DOI: 10.1097/Nen.0B013E318182F36E  0.476
2008 O'Shea M, Maytham EG, Linehan JM, Brandner S, Collinge J, Lloyd SE. Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse. Genetics. 180: 559-66. PMID 18716327 DOI: 10.1534/Genetics.108.090894  0.418
2008 Cronier S, Gros N, Tattum MH, Jackson GS, Clarke AR, Collinge J, Wadsworth JD. Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin. The Biochemical Journal. 416: 297-305. PMID 18684106 DOI: 10.1042/Bj20081235  0.443
2008 Isaacs AM, Powell C, Webb TE, Linehan JM, Collinge J, Brandner S. Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases. Neuropathology and Applied Neurobiology. 34: 446-56. PMID 18657254 DOI: 10.1111/J.1365-2990.2008.00963.X  0.485
2008 Rohrer JD, Warren JD, Barnes J, Mead S, Beck J, Pepple T, Boyes R, Omar R, Collinge J, Stevens JM, Warrington EK, Rossor MN, Fox NC. Mapping the progression of progranulin-associated frontotemporal lobar degeneration. Nature Clinical Practice. Neurology. 4: 455-60. PMID 18648346 DOI: 10.1038/Ncpneuro0869  0.34
2008 Ratté S, Prescott SA, Collinge J, Jefferys JG. Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD. Neurobiology of Disease. 32: 96-104. PMID 18638557 DOI: 10.1016/J.Nbd.2008.06.007  0.621
2008 White MD, Farmer M, Mirabile I, Brandner S, Collinge J, Mallucci GR. Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 10238-43. PMID 18632556 DOI: 10.1073/Pnas.0802759105  0.44
2008 Wadsworth JD, Powell C, Beck JA, Joiner S, Linehan JM, Brandner S, Mead S, Collinge J. Molecular diagnosis of human prion disease. Methods in Molecular Biology (Clifton, N.J.). 459: 197-227. PMID 18576157 DOI: 10.1007/978-1-59745-234-2_14  0.445
2008 Rohrer JD, Warren JD, Omar R, Mead S, Beck J, Revesz T, Holton J, Stevens JM, Al-Sarraj S, Pickering-Brown SM, Hardy J, Fox NC, Collinge J, Warrington EK, Rossor MN. Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene. Archives of Neurology. 65: 506-13. PMID 18413474 DOI: 10.1001/Archneur.65.4.506  0.465
2008 Powell AD, Toescu EC, Collinge J, Jefferys JG. Alterations in Ca2+-buffering in prion-null mice: association with reduced afterhyperpolarizations in CA1 hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3877-86. PMID 18400886 DOI: 10.1523/Jneurosci.0675-08.2008  0.549
2008 Wadsworth JD, Joiner S, Linehan JM, Desbruslais M, Fox K, Cooper S, Cronier S, Asante EA, Mead S, Brandner S, Hill AF, Collinge J. Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 3885-90. PMID 18316717 DOI: 10.1073/Pnas.0800190105  0.437
2008 Beck J, Rohrer JD, Campbell T, Isaacs A, Morrison KE, Goodall EF, Warrington EK, Stevens J, Revesz T, Holton J, Al-Sarraj S, King A, Scahill R, Warren JD, Fox NC, ... ... Collinge J, et al. A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain : a Journal of Neurology. 131: 706-20. PMID 18234697 DOI: 10.1093/Brain/Awm320  0.386
2008 van der Zee J, Urwin H, Engelborghs S, Bruyland M, Vandenberghe R, Dermaut B, De Pooter T, Peeters K, Santens P, De Deyn PP, Fisher EM, Collinge J, Isaacs AM, Van Broeckhoven C. CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro. Human Molecular Genetics. 17: 313-22. PMID 17956895 DOI: 10.1093/Hmg/Ddm309  0.327
2008 Mead S, Poulter M, Uphill J, Beck J, Webb T, Campbell T, Adamson G, Molonou E, Hummerich H, Verzilli C, Whittaker J, Collinge J. P2-211: Genome-wide association study identifies genetic risk factors for variant Creutzfeldt-Jakob disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1286  0.389
2007 Mead S, Joiner S, Desbruslais M, Beck JA, O'Donoghue M, Lantos P, Wadsworth JD, Collinge J. Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman. Archives of Neurology. 64: 1780-4. PMID 18071044 DOI: 10.1001/Archneur.64.12.1780  0.449
2007 Collinge J, Clarke AR. A general model of prion strains and their pathogenicity. Science (New York, N.Y.). 318: 930-6. PMID 17991853 DOI: 10.1126/Science.1138718  0.332
2007 Khalili-Shirazi A, Kaisar M, Mallinson G, Jones S, Bhelt D, Fraser C, Clarke AR, Hawke SH, Jackson GS, Collinge J. Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc. Biochimica Et Biophysica Acta. 1774: 1438-50. PMID 17936697 DOI: 10.1016/J.Bbapap.2007.08.028  0.31
2007 Mead S, Webb TE, Campbell TA, Beck J, Linehan JM, Rutherfoord S, Joiner S, Wadsworth JD, Heckmann J, Wroe S, Doey L, King A, Collinge J. Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129. Neurology. 69: 730-8. PMID 17709704 DOI: 10.1212/01.Wnl.0000267642.41594.9D  0.447
2007 Knight WD, Kennedy J, Mead S, Rossor MN, Beck J, Collinge J, Mummery C. A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 14: 829-31. PMID 17594345 DOI: 10.1111/J.1468-1331.2007.01857.X  0.443
2007 Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menéndez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ. Disease-associated prion protein oligomers inhibit the 26S proteasome. Molecular Cell. 26: 175-88. PMID 17466621 DOI: 10.1016/J.Molcel.2007.04.001  0.395
2007 Wadsworth JD, Collinge J. Update on human prion disease. Biochimica Et Biophysica Acta. 1772: 598-609. PMID 17408929 DOI: 10.1016/J.Bbadis.2007.02.010  0.458
2007 Kovács T, Beck JA, Papp MI, Lantos PL, Arányi Z, Szirmai IG, Farsang M, Stuke A, Csillik A, Collinge J. Familial prion disease in a Hungarian family with a novel 144-base pair insertion in the prion protein gene. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 321-3. PMID 17308293 DOI: 10.1136/Jnnp.2006.104372  0.447
2007 Mallucci GR, White MD, Farmer M, Dickinson A, Khatun H, Powell AD, Brandner S, Jefferys JG, Collinge J. Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron. 53: 325-35. PMID 17270731 DOI: 10.1016/J.Neuron.2007.01.005  0.625
2007 Macfarlane RG, Wroe SJ, Collinge J, Yousry TA, Jäger HR. Neuroimaging findings in human prion disease. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 664-70. PMID 17135459 DOI: 10.1136/Jnnp.2006.094821  0.399
2007 Wadsworth JD, Joiner S, Fox K, Linehan JM, Desbruslais M, Brandner S, Asante EA, Collinge J. Prion infectivity in variant Creutzfeldt-Jakob disease rectum. Gut. 56: 90-4. PMID 16763054 DOI: 10.1136/Gut.2006.091637  0.39
2006 Wroe SJ, Pal S, Siddique D, Hyare H, Macfarlane R, Joiner S, Linehan JM, Brandner S, Wadsworth JD, Hewitt P, Collinge J. Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report. Lancet. 368: 2061-7. PMID 17161728 DOI: 10.1016/S0140-6736(06)69835-8  0.364
2006 Kotta K, Paspaltsis I, Bostantjopoulou S, Latsoudis H, Plaitakis A, Kazis D, Collinge J, Sklaviadis T. Novel mutation of the PRNP gene of a clinical CJD case. Bmc Infectious Diseases. 6: 169. PMID 17129366 DOI: 10.1186/1471-2334-6-169  0.433
2006 Isaacs JD, Ingram RJ, Collinge J, Altmann DM, Jackson GS. The human prion protein residue 129 polymorphism lies within a cluster of epitopes for T cell recognition. Journal of Neuropathology and Experimental Neurology. 65: 1059-68. PMID 17086102 DOI: 10.1097/01.Jnen.0000240467.18381.49  0.341
2006 Rohrer JD, Mead S, Omar R, Poulter M, Warren JD, Collinge J, Rossor MN. Prion protein (PRNP) genotypes in frontotemporal lobar degeneration syndromes. Annals of Neurology. 60: 616; author reply 61. PMID 16969862 DOI: 10.1002/Ana.20931  0.318
2006 Collinge J, Alpers MP. Incubation period of human prion disease - Author's reply Lancet. 368: 914-915. PMID 16962872 DOI: 10.1016/S0140-6736(06)69363-X  0.407
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2006 Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology. 67: 1074-7. PMID 16807408 DOI: 10.1212/01.Wnl.0000231510.89311.8B  0.309
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2006 Lewis PA, Properzi F, Prodromidou K, Clarke AR, Collinge J, Jackson GS. Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity. The Biochemical Journal. 395: 443-8. PMID 16441239 DOI: 10.1042/Bj20051677  0.318
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2005 Hosszu LL, Wells MA, Jackson GS, Jones S, Batchelor M, Clarke AR, Craven CJ, Waltho JP, Collinge J. Definable equilibrium states in the folding of human prion protein. Biochemistry. 44: 16649-57. PMID 16342955 DOI: 10.1021/Bi051277K  0.308
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2005 Jones S, Batchelor M, Bhelt D, Clarke AR, Collinge J, Jackson GS. Recombinant prion protein does not possess SOD-1 activity. The Biochemical Journal. 392: 309-12. PMID 16156720 DOI: 10.1042/Bj20051236  0.32
2005 Khalili-Shirazi A, Summers L, Linehan J, Mallinson G, Anstee D, Hawke S, Jackson GS, Collinge J. PrP glycoforms are associated in a strain-specific ratio in native PrPSc. The Journal of General Virology. 86: 2635-44. PMID 16099923 DOI: 10.1099/Vir.0.80375-0  0.393
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2005 Collinge J. Molecular neurology of prion disease. Journal of Neurology, Neurosurgery, and Psychiatry. 76: 906-19. PMID 15965195 DOI: 10.1136/Jnnp.2004.048660  0.429
2005 Hirsch N, Beckett A, Collinge J, Scaravilli F, Tabrizi S, Berry S. Lymphocyte contamination of laryngoscope blades--a possible vector for transmission of variant Creutzfeldt-Jakob disease. Anaesthesia. 60: 664-7. PMID 15960716 DOI: 10.1111/J.1365-2044.2005.04221.X  0.345
2005 Mead S, Prout K, Collinge J. Questionnaire to reduce the risk of iatrogenic prion disease transmission. The Journal of Hospital Infection. 60: 378-9. PMID 15939508 DOI: 10.1016/J.Jhin.2005.02.003  0.384
2005 Khalili-Shirazi A, Quaratino S, Londei M, Summers L, Tayebi M, Clarke AR, Hawke SH, Jackson GS, Collinge J. Protein conformation significantly influences immune responses to prion protein. Journal of Immunology (Baltimore, Md. : 1950). 174: 3256-63. PMID 15749856 DOI: 10.4049/Jimmunol.174.6.3256  0.369
2005 Jackson GS, McKintosh E, Flechsig E, Prodromidou K, Hirsch P, Linehan J, Brandner S, Clarke AR, Weissmann C, Collinge J. An enzyme-detergent method for effective prion decontamination of surgical steel. The Journal of General Virology. 86: 869-78. PMID 15722550 DOI: 10.1099/Vir.0.80484-0  0.32
2005 Cordery RJ, Alner K, Cipolotti L, Ron M, Kennedy A, Collinge J, Rossor MN. The neuropsychology of variant CJD: a comparative study with inherited and sporadic forms of prion disease. Journal of Neurology, Neurosurgery, and Psychiatry. 76: 330-6. PMID 15716521 DOI: 10.1136/Jnnp.2003.030320  0.377
2005 Mallucci G, Collinge J. Rational targeting for prion therapeutics. Nature Reviews. Neuroscience. 6: 23-34. PMID 15611724 DOI: 10.1038/Nrn1584  0.44
2005 Hafezparast M, Brandner S, Linehan J, Martin JE, Collinge J, Fisher EM. Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Biochemical and Biophysical Research Communications. 326: 18-22. PMID 15567146 DOI: 10.1016/J.Bbrc.2004.10.206  0.397
2004 Tayebi M, Enever P, Sattar Z, Collinge J, Hawke S. Disease-associated prion protein elicits immunoglobulin M responses in vivo. Molecular Medicine (Cambridge, Mass.). 10: 104-11. PMID 15706401 DOI: 10.2119/2004-00027.Tayebi  0.399
2004 Mallucci G, Collinge J. Update on Creutzfeldt-Jakob disease. Current Opinion in Neurology. 17: 641-7. PMID 15542971 DOI: 10.1097/00019052-200412000-00002  0.461
2004 Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J. Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science (New York, N.Y.). 306: 1793-6. PMID 15539564 DOI: 10.1126/Science.1103932  0.43
2004 Godbolt AK, Beck JA, Collinge J, Garrard P, Warren JD, Fox NC, Rossor MN. A presenilin 1 R278I mutation presenting with language impairment. Neurology. 63: 1702-4. PMID 15534260 DOI: 10.1212/01.Wnl.0000143060.98164.1A  0.342
2004 Frosh A, Smith LC, Jackson CJ, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein. Lancet. 364: 1260-2. PMID 15464187 DOI: 10.1016/S0140-6736(04)17143-2  0.416
2004 Lloyd SE, Linehan JM, Desbruslais M, Joiner S, Buckell J, Brandner S, Wadsworth JD, Collinge J. Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice. The Journal of General Virology. 85: 2471-8. PMID 15269389 DOI: 10.1099/Vir.0.79889-0  0.401
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2004 Lloyd SE, Thompson SR, Beck JA, Linehan JM, Wadsworth JD, Brandner S, Collinge J, Fisher EM. Identification and characterization of a novel mouse prion gene allele. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 383-9. PMID 15170227 DOI: 10.1007/S00335-004-3041-5  0.381
2004 Beringue V, Vilette D, Mallinson G, Archer F, Kaisar M, Tayebi M, Jackson GS, Clarke AR, Laude H, Collinge J, Hawke S. PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. The Journal of Biological Chemistry. 279: 39671-6. PMID 15133046 DOI: 10.1074/Jbc.M402270200  0.376
2004 Hosszu LL, Jackson GS, Trevitt CR, Jones S, Batchelor M, Bhelt D, Prodromidou K, Clarke AR, Waltho JP, Collinge J. The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC. The Journal of Biological Chemistry. 279: 28515-21. PMID 15123682 DOI: 10.1074/Jbc.M313762200  0.432
2004 Beck JA, Poulter M, Campbell TA, Uphill JB, Adamson G, Geddes JF, Revesz T, Davis MB, Wood NW, Collinge J, Tabrizi SJ. Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. Human Molecular Genetics. 13: 1219-24. PMID 15115757 DOI: 10.1093/Hmg/Ddh134  0.471
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2003 Hill AF, Joiner S, Wadsworth JD, Sidle KC, Bell JE, Budka H, Ironside JW, Collinge J. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain : a Journal of Neurology. 126: 1333-46. PMID 12764055 DOI: 10.1093/Brain/Awg125  0.442
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2003 Mead S, Stumpf MP, Whitfield J, Beck JA, Poulter M, Campbell T, Uphill JB, Goldstein D, Alpers M, Fisher EM, Collinge J. Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics. Science (New York, N.Y.). 300: 640-3. PMID 12690204 DOI: 10.1126/Science.1083320  0.416
2003 King A, Doey L, Rossor M, Mead S, Collinge J, Lantos P. Phenotypic variability in the brains of a family with a prion disease characterized by a 144-base pair insertion in the prion protein gene. Neuropathology and Applied Neurobiology. 29: 98-105. PMID 12662318 DOI: 10.1046/J.1365-2990.2003.00423.X  0.442
2003 White AR, Enever P, Tayebi M, Mushens R, Linehan J, Brandner S, Anstee D, Collinge J, Hawke S. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature. 422: 80-3. PMID 12621436 DOI: 10.1038/Nature01457  0.441
2003 Janssen JC, Beck JA, Campbell TA, Dickinson A, Fox NC, Harvey RJ, Houlden H, Rossor MN, Collinge J. Early onset familial Alzheimer's disease: Mutation frequency in 31 families. Neurology. 60: 235-9. PMID 12552037 DOI: 10.1212/01.Wnl.0000042088.22694.E3  0.379
2002 Makrinou E, Collinge J, Antoniou M. Genomic characterization of the human prion protein (PrP) gene locus. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 13: 696-703. PMID 12514748 DOI: 10.1007/S00335-002-3043-0  0.348
2002 Lloyd SE, Uphill JB, Targonski PV, Fisher EM, Collinge J. Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice. Neurogenetics. 4: 77-81. PMID 12481985 DOI: 10.1007/S10048-002-0133-9  0.419
2002 Asante EA, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, Welch J, Hill AF, Lloyd SE, Wadsworth JD, Collinge J. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. The Embo Journal. 21: 6358-66. PMID 12456643 DOI: 10.1093/Emboj/Cdf653  0.448
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2002 Mallucci GR, Ratté S, Asante EA, Linehan J, Gowland I, Jefferys JG, Collinge J. Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. The Embo Journal. 21: 202-10. PMID 11823413 DOI: 10.1093/Emboj/21.3.202  0.628
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2001 Jackson GS, Collinge J. The molecular pathology of CJD: old and new variants. Molecular Pathology : Mp. 54: 393-9. PMID 11724914  0.312
2001 Jackson GS, Beck JA, Navarrete C, Brown J, Sutton PM, Contreras M, Collinge J. HLA-DQ7 antigen and resistance to variant CJD. Nature. 414: 269-70. PMID 11713518 DOI: 10.1038/35104694  0.376
2001 Flechsig E, Hegyi I, Enari M, Schwarz P, Collinge J, Weissmann C. Transmission of scrapie by steel-surface-bound prions. Molecular Medicine (Cambridge, Mass.). 7: 679-84. PMID 11713367 DOI: 10.1007/Bf03401958  0.33
2001 Mead S, Mahal SP, Beck J, Campbell T, Farrall M, Fisher E, Collinge J. Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1. American Journal of Human Genetics. 69: 1225-35. PMID 11704923 DOI: 10.1086/324710  0.491
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2001 Beck JA, Mead S, Campbell TA, Dickinson A, Wientjens DP, Croes EA, Van Duijn CM, Collinge J. Two-octapeptide repeat deletion of prion protein associated with rapidly progressive dementia. Neurology. 57: 354-6. PMID 11468331  0.411
2001 Asante EA, Collinge J. Transgenic studies of the influence of the PrP structure on TSE diseases. Advances in Protein Chemistry. 57: 273-311. PMID 11447693 DOI: 10.1016/S0065-3233(01)57025-4  0.459
2001 Janssen JC, Lantos PL, Fox NC, Harvey RJ, Beck J, Dickinson A, Campbell TA, Collinge J, Hanger DP, Cipolotti L, Stevens JM, Rossor MN. Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation. Archives of Neurology. 58: 953-8. PMID 11405810 DOI: 10.1001/Archneur.58.6.953  0.391
2001 Mahal SP, Asante EA, Antoniou M, Collinge J. Isolation and functional characterisation of the promoter region of the human prion protein gene. Gene. 268: 105-14. PMID 11368906 DOI: 10.1016/S0378-1119(01)00424-3  0.328
2001 Lloyd SE, Onwuazor ON, Beck JA, Mallinson G, Farrall M, Targonski P, Collinge J, Fisher EM. Identification of multiple quantitative trait loci linked to prion disease incubation period in mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 6279-83. PMID 11353827 DOI: 10.1073/Pnas.101130398  0.442
2001 Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annual Review of Neuroscience. 24: 519-50. PMID 11283320 DOI: 10.1146/Annurev.Neuro.24.1.519  0.461
2001 Clarke AR, Jackson GS, Collinge J. The molecular biology of prion propagation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 185-95. PMID 11260799 DOI: 10.1098/Rstb.2000.0764  0.439
2000 Jackson GS, Collinge J. Prion disease--the propagation of infectious protein topologies. Microbes and Infection / Institut Pasteur. 2: 1445-9. PMID 11099931 DOI: 10.1016/S1286-4579(00)01299-5  0.389
2000 Hill AF, Joiner S, Linehan J, Desbruslais M, Lantos PL, Collinge J. Species-barrier-independent prion replication in apparently resistant species. Proceedings of the National Academy of Sciences of the United States of America. 97: 10248-53. PMID 10963685 DOI: 10.1073/Pnas.97.18.10248  0.333
2000 Mead S, Beck J, Dickinson A, Fisher EM, Collinge J. Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease. Neuroscience Letters. 290: 117-20. PMID 10936691 DOI: 10.1016/S0304-3940(00)01319-7  0.479
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1999 Wadsworth JD, Hill AF, Joiner S, Jackson GS, Clarke AR, Collinge J. Strain-specific prion-protein conformation determined by metal ions. Nature Cell Biology. 1: 55-9. PMID 10559865 DOI: 10.1038/9030  0.398
1999 Mallucci GR, Campbell TA, Dickinson A, Beck J, Holt M, Plant G, de Pauw KW, Hakin RN, Clarke CE, Howell S, Davies-Jones GA, Lawden M, Smith CM, Ince P, Ironside JW, ... ... Collinge J, et al. Inherited prion disease with an alanine to valine mutation at codon 117 in the prion protein gene. Brain : a Journal of Neurology. 122: 1823-37. PMID 10506086 DOI: 10.1093/Brain/122.10.1823  0.511
1999 Collinge J. Variant Creutzfeldt-Jakob disease. Lancet. 354: 317-23. PMID 10440324 DOI: 10.1016/S0140-6736(99)05128-4  0.45
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1999 Palmer MS, Beck JA, Campbell TA, Humphries CB, Roques PK, Fox NC, Harvey R, Rossor MN, Collinge J. Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online. Human Mutation. 13: 256. PMID 10090481 DOI: 10.1002/(Sici)1098-1004(1999)13:3<256::Aid-Humu11>3.0.Co;2-P  0.373
1999 Jackson GS, Hosszu LL, Power A, Hill AF, Kenney J, Saibil H, Craven CJ, Waltho JP, Clarke AR, Collinge J. Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations. Science (New York, N.Y.). 283: 1935-7. PMID 10082469 DOI: 10.1126/Science.283.5409.1935  0.319
1999 Almer G, Hainfellner JA, Brücke T, Jellinger K, Kleinert R, Bayer G, Windl O, Kretzschmar HA, Hill A, Sidle K, Collinge J, Budka H. Fatal familial insomnia: a new Austrian family. Brain : a Journal of Neurology. 122: 5-16. PMID 10050890 DOI: 10.1093/Brain/122.1.5  0.36
1999 Hill AF, Antoniou M, Collinge J. Protease-resistant prion protein produced in vitro lacks detectable infectivity. The Journal of General Virology. 80: 11-4. PMID 9934677 DOI: 10.1099/0022-1317-80-1-11  0.318
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1998 Hill AF, Sidle KC, Joiner S, Keyes P, Martin TC, Dawson M, Collinge J. Molecular screening of sheep for bovine spongiform encephalopathy. Neuroscience Letters. 255: 159-62. PMID 9832197 DOI: 10.1016/S0304-3940(98)00736-8  0.324
1998 Collinge J, Rossor MN, Thomas D, Frosh A, Tolley N. Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum. Tonsil biopsy helps diagnose new variant Creutzfeldt-Jakob disease. Bmj (Clinical Research Ed.). 317: 472-3. PMID 9758471  0.322
1998 Fisher E, Telling G, Collinge J. Prions and the prion disorders. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 497-502. PMID 9657843 DOI: 10.1007/S003359900807  0.397
1998 Harvey RJ, Ellison D, Hardy J, Hutton M, Roques PK, Collinge J, Fox NC, Rossor MN. Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene. Journal of Neurology, Neurosurgery, and Psychiatry. 64: 44-9. PMID 9436726 DOI: 10.1136/Jnnp.64.1.44  0.631
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1997 Hill AF, Will RG, Ironside J, Collinge J. Type of prion protein in UK farmers with Creutzfeldt-Jakob disease. Lancet. 350: 188. PMID 9250195 DOI: 10.1016/S0140-6736(05)62356-2  0.391
1997 Lantos PL, Bhatia K, Doey LJ, al-Sarraj S, Doshi R, Beck J, Collinge J. Is the neuropathology of new variant Creutzfeldt-Jakob disease and kuru similar? Lancet. 350: 187-8. PMID 9250194 DOI: 10.1016/S0140-6736(05)62355-0  0.45
1997 Colling SB, Khana M, Collinge J, Jefferys JG. Mossy fibre reorganization in the hippocampus of prion protein null mice. Brain Research. 755: 28-35. PMID 9163538 DOI: 10.1016/S0006-8993(97)00087-5  0.58
1997 Basun H, Almkvist O, Axelman K, Brun A, Campbell TA, Collinge J, Forsell C, Froelich S, Wahlund LO, Wetterberg L, Lannfelt L. Clinical characteristics of a chromosome 17-linked rapidly progressive familial frontotemporal dementia. Archives of Neurology. 54: 539-44. PMID 9152110 DOI: 10.1001/Archneur.1997.00550170021010  0.385
1997 Fox NC, Kennedy AM, Harvey RJ, Lantos PL, Roques PK, Collinge J, Hardy J, Hutton M, Stevens JM, Warrington EK, Rossor MN. Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor. Brain : a Journal of Neurology. 120: 491-501. PMID 9126060 DOI: 10.1093/Brain/120.3.491  0.519
1997 Esiri MM, Gordon WI, Collinge J, Patten JS. Peripheral neuropathy in Creutzfeldt-Jakob disease. Neurology. 48: 784. PMID 9065568  0.309
1997 Hill AF, Zeidler M, Ironside J, Collinge J. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet. 349: 99-100. PMID 8996424 DOI: 10.1016/S0140-6736(97)24002-X  0.395
1997 Deslys JP, Lasmézas CI, Streichenberger N, Hill A, Collinge J, Dormont D, Kopp N. New variant Creutzfeldt-Jakob disease in France. Lancet. 349: 30-1. PMID 8988126 DOI: 10.1016/S0140-6736(05)62163-0  0.436
1997 Mallucci GR, Collinge J. Neuropsychiatric presentations of prion disease Current Opinion in Psychiatry. 10: 59-62. DOI: 10.1097/00001504-199701000-00013  0.463
1996 Collinge J, Sidle KC, Meads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature. 383: 685-90. PMID 8878476 DOI: 10.1038/383685A0  0.42
1996 Collinge J. New diagnostic tests for prion diseases. The New England Journal of Medicine. 335: 963-5. PMID 8782506 DOI: 10.1056/Nejm199609263351310  0.455
1996 Colling SB, Collinge J, Jefferys JG. Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents. Neuroscience Letters. 209: 49-52. PMID 8734907 DOI: 10.1016/0304-3940(96)12596-9  0.56
1996 Windl O, Dempster M, Estibeiro JP, Lathe R, de Silva R, Esmonde T, Will R, Springbett A, Campbell TA, Sidle KC, Palmer MS, Collinge J. Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene. Human Genetics. 98: 259-64. PMID 8707291 DOI: 10.1007/S004390050204  0.461
1996 Collinge J, Beck J, Campbell T, Estibeiro K, Will RG. Prion protein gene analysis in new variant cases of Creutzfeldt-Jakob disease. Lancet. 348: 56. PMID 8691941 DOI: 10.1016/S0140-6736(05)64378-4  0.439
1996 Rossor MN, Fox NC, Beck J, Campbell TC, Collinge J. Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation. Lancet. 347: 1560. PMID 8684135 DOI: 10.1016/S0140-6736(96)90715-1  0.419
1996 Campbell TA, Palmer MS, Will RG, Gibb WR, Luthert PJ, Collinge J. A prion disease with a novel 96-base pair insertional mutation in the prion protein gene. Neurology. 46: 761-6. PMID 8618679  0.376
1996 Tabrizi SJ, Howard RS, Collinge J, Rossor MN, Scaravilli F. Creutzfeldt-Jakob disease in a young woman Lancet. 347: 945-948. PMID 8598761 DOI: 10.1016/S0140-6736(96)91419-1  0.433
1996 Collinge J, Rossor M. A new variant of prion disease. Lancet. 347: 916-7. PMID 8598749 DOI: 10.1016/S0140-6736(96)91407-5  0.45
1995 Brown J, Ashworth A, Gydesen S, Sorensen A, Rossor M, Hardy J, Collinge J. Familial non-specific dementia maps to chromosome 3. Human Molecular Genetics. 4: 1625-8. PMID 8541850 DOI: 10.1093/Hmg/4.9.1625  0.502
1995 Collinge J, Palmer MS, Sidle KC, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL. Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature. 378: 779-83. PMID 8524411 DOI: 10.1038/378779A0  0.394
1995 Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ. Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases) Brain Pathology (Zurich, Switzerland). 5: 319-22. PMID 8520732 DOI: 10.1111/J.1750-3639.1995.Tb00609.X  0.374
1995 Whittington MA, Sidle KC, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JG, Collinge J. Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein. Nature Genetics. 9: 197-201. PMID 7719349 DOI: 10.1038/Ng0295-197  0.641
1995 Ashworth A, Brown J, Gydesen S, Sorensen SA, Rossor MN, Hardy J, Collinge J. Frontal lobe or 'nonspecific' dementias are genetically heterogeneous. Neurology. 45: 1781. PMID 7675248 DOI: 10.1212/Wnl.45.9.1781  0.31
1995 Houlden H, Crook R, Duff K, Hutton M, Collinge J, Roques P, Rossor M, Hardy J. Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease. Neuroscience Letters. 188: 202-4. PMID 7609909 DOI: 10.1016/0304-3940(95)11422-S  0.706
1995 Bateman D, Hilton D, Love S, Zeidler M, Beck J, Collinge J. Sporadic Creutzfeldt-Jakob disease in a 18-year-old in the UK. The Lancet. 346: 1155-1156. PMID 7475612 DOI: 10.1016/S0140-6736(95)91828-0  0.375
1995 Britton TC, al-Sarraj S, Shaw C, Campbell T, Collinge J. Sporadic Creutzfeldt-Jakob disease in a 16-year-old in the UK. Lancet. 346: 1155. PMID 7475611 DOI: 10.1016/S0140-6736(95)91827-2  0.375
1995 Collinge J. Molecular and Cell Biology of Neuropsychiatric Diseases Journal of Neurology, Neurosurgery, and Psychiatry. 58: 767-768. DOI: 10.1136/Jnnp.58.6.767-C  0.373
1995 Whittington MA, Sidle KCL, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JGR, Collinge J. Erratum: Corrigendum: Rescue of neurophysiological phenotype seen in PRP null mice by transgene encoding human prion protein Nature Genetics. 9: 451-451. DOI: 10.1038/Ng0495-451D  0.347
1994 Collinge J, Whittington MA, Sidle KC, Smith CJ, Palmer MS, Clarke AR, Jefferys JG. Prion protein is necessary for normal synaptic function. Nature. 370: 295-7. PMID 8035877 DOI: 10.1038/370295A0  0.65
1994 Collinge J, Palmer MS, Sidle KC, Mahal SP, Campbell T, Brown J, Hardy J, Brun AE, Gustafson L, Bakker E. Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease. Journal of Neurology, Neurosurgery, and Psychiatry. 57: 762. PMID 8006666  0.361
1994 Houlden H, Crook R, Hardy J, Roques P, Collinge J, Rossor M. Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus. Neuroscience Letters. 174: 222-4. PMID 7970184 DOI: 10.1016/0304-3940(94)90026-4  0.506
1994 Telling GC, Scott M, Hsiao KK, Foster D, Yang SL, Torchia M, Sidle KC, Collinge J, DeArmond SJ, Prusiner SB. Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 9936-40. PMID 7937921 DOI: 10.1073/Pnas.91.21.9936  0.389
1994 Collinge J, Palmer MS. Molecular genetics of human prion diseases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 343: 371-8. PMID 7913754 DOI: 10.1098/Rstb.1994.0031  0.515
1993 Collinge J, Palmer MS, Campbell T, Sidle KC, Carroll D, Harding A. Inherited prion disease (PrP lysine 200) in Britain: two case reports. Bmj (Clinical Research Ed.). 306: 301-2. PMID 8461647 DOI: 10.1136/Bmj.306.6873.301  0.442
1993 Brown J, Gydesen S, Sorensen SA, Brun A, Smith S, Houlden H, Twells R, Mullan M, Rossor M, Collinge J. Genetic characterization of a familial non-specific dementia originating in Jutland, Denmark. Journal of the Neurological Sciences. 114: 138-43. PMID 8445394 DOI: 10.1016/0022-510X(93)90288-A  0.613
1993 Collinge J, Palmer MS. Prion diseases in humans and their relevance to other neurodegenerative diseases. Dementia (Basel, Switzerland). 4: 178-85. PMID 8401789 DOI: 10.1159/000107320  0.536
1993 Palmer MS, Collinge J. Mutations and polymorphisms in the prion protein gene. Human Mutation. 2: 168-73. PMID 8364585 DOI: 10.1002/Humu.1380020303  0.42
1993 Palmer MS, Mahal SP, Campbell TA, Hill AF, Sidle KC, Laplanche JL, Collinge J. Deletions in the prion protein gene are not associated with CJD. Human Molecular Genetics. 2: 541-4. PMID 8100163 DOI: 10.1093/Hmg/2.5.541  0.457
1993 Weber T, Tumani H, Holdorff B, Collinge J, Palmer M, Kretzschmar H, Felgenhauer K. Transmission of Creutzfeldt-Jakob disease by handling of dura mater. The Lancet. 341: 123-124. PMID 8093398 DOI: 10.1016/0140-6736(93)92608-V  0.426
1993 Collinge J. Memory and molecules Nature. 366: 122-122. DOI: 10.1038/366122A0  0.353
1992 Lantos PL, McGill IS, Janota I, Doey LJ, Collinge J, Bruce MT, Whatley SA, Anderton BH, Clinton J, Roberts GW. Prion protein immunocytochemistry helps to establish the true incidence of prion diseases. Neuroscience Letters. 147: 67-71. PMID 1480325 DOI: 10.1016/0304-3940(92)90776-4  0.485
1992 Collinge J, Brown J, Hardy J, Mullan M, Rossor MN, Baker H, Crow TJ, Lofthouse R, Poulter M, Ridley R. Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features. Brain : a Journal of Neurology. 115: 687-710. PMID 1352725 DOI: 10.1093/Brain/115.3.687  0.603
1992 Owen F, Poulter M, Collinge J, Leach M, Lofthouse R, Crow TJ, Harding AE. A dementing illness associated with a novel insertion in the prion protein gene. Molecular Brain Research. 13: 155-157. PMID 1349721 DOI: 10.1016/0169-328X(92)90056-H  0.322
1992 Palmer MS, Sidle KCL, Campbell TA, Roberts GW, Plant G, Collinge J. Absence of PRP gene mutation in patient showing PRP immunostaining Neurobiology of Aging. 13. DOI: 10.1016/0197-4580(92)90497-L  0.311
1991 Brown J, Smith S, Brun A, Collinge J, Gydesen S, Hardy J, Mullan M, Goate A. Genetic characterization of a novel familial dementia. Annals of the New York Academy of Sciences. 640: 181-3. PMID 1776737 DOI: 10.1111/J.1749-6632.1991.Tb00213.X  0.685
1991 Palmer MS, Dryden AJ, Hughes JT, Collinge J. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature. 352: 340-2. PMID 1677164 DOI: 10.1038/352340A0  0.503
1991 Collinge J, Palmer MS, Dryden AJ. Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. Lancet (London, England). 337: 1441-2. PMID 1675319 DOI: 10.1016/0140-6736(91)93128-V  0.435
1991 Owen F, Poulter M, Collinge J, Leach M, Shah T, Lofthouse R, Chen YF, Crow TJ, Harding AE, Hardy J. Insertions in the prion protein gene in atypical dementias. Experimental Neurology. 112: 240-2. PMID 1674696 DOI: 10.1016/0014-4886(91)90075-N  0.523
1991 Palmer MS, Dryden AJ, Hughes JT, Collinge J. Erratum: Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease Nature. 352: 547-547. DOI: 10.1038/352547A0  0.39
1990 Owen F, Poulter M, Shah T, Collinge J, Lofthouse R, Baker H, Ridley R, McVey J, Crow TJ. An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease. Brain Research. Molecular Brain Research. 7: 273-6. PMID 2159587 DOI: 10.1016/0169-328X(90)90038-F  0.422
1990 Collinge J, Owen F, Poulter M, Leach M, Crow TJ, Rossor MN, Hardy J, Mullan MJ, Janota I, Lantos PL. Prion dementia without characteristic pathology. Lancet. 336: 7-9. PMID 1973256 DOI: 10.1016/0140-6736(90)91518-F  0.62
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