| Year |
Citation |
Score |
| 2021 |
Norris HL, Kumar R, Edgerton M. A Novel Role for Histatin 5 in Combination with Zinc to Promote Commensalism in Survivor Cells. Pathogens (Basel, Switzerland). 10. PMID 34959564 DOI: 10.3390/pathogens10121609 |
0.316 |
|
| 2020 |
Norris HL, Kumar R, Ong CY, Xu D, Edgerton M. Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption in and . Journal of Fungi (Basel, Switzerland). 6. PMID 32751915 DOI: 10.3390/Jof6030124 |
0.402 |
|
| 2019 |
Puri S, Kumar R, Rojas IG, Salvatori O, Edgerton M. Iron Chelator Deferasirox Reduces Invasion of Oral Epithelial Cells and Infection Levels in Murine Oropharyngeal Candidiasis. Antimicrobial Agents and Chemotherapy. PMID 30718249 DOI: 10.1128/Aac.02152-18 |
0.317 |
|
| 2018 |
McCall AD, Kumar R, Edgerton M. Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies. Plos Pathogens. 14: e1007316. PMID 30252918 DOI: 10.1371/Journal.Ppat.1007316 |
0.384 |
|
| 2018 |
Salvatori O, Pathirana RU, Kay JG, Edgerton M. Ras1 inactivation increases resistance to phagosomal killing by human neutrophils. Infection and Immunity. PMID 30249746 DOI: 10.1128/Iai.00685-18 |
0.389 |
|
| 2017 |
McCall A, Edgerton M. Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development. Journal of Fungi (Basel, Switzerland). 3. PMID 29371532 DOI: 10.3390/Jof3010013 |
0.365 |
|
| 2017 |
Pathirana RU, Friedman J, Norris HL, Salvatori O, McCall AD, Kay J, Edgerton M. Fluconazole Resistant Candida auris is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses. Antimicrobial Agents and Chemotherapy. PMID 29158282 DOI: 10.1128/Aac.01872-17 |
0.403 |
|
| 2017 |
Hampe IAI, Friedman J, Edgerton M, Morschhäuser J. An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses. Plos Pathogens. 13: e1006655. PMID 28953977 DOI: 10.1371/Journal.Ppat.1006655 |
0.361 |
|
| 2017 |
Kumar R, Breindel C, Saraswat D, Cullen PJ, Edgerton M. Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition. Scientific Reports. 7: 2908. PMID 28588252 DOI: 10.1038/S41598-017-03082-4 |
0.432 |
|
| 2017 |
Du H, Puri S, McCall A, Norris HL, Russo T, Edgerton M. Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens. Frontiers in Cellular and Infection Microbiology. 7: 41. PMID 28261570 DOI: 10.3389/Fcimb.2017.00041 |
0.399 |
|
| 2016 |
Cullen PJ, Edgerton M. Unmasking Fungal Pathogens by Studying MAPK-Dependent Cell Wall Regulation in Candida albicans. Virulence. 0. PMID 27088569 DOI: 10.1080/21505594.2016.1177695 |
0.386 |
|
| 2016 |
Tati S, Davidow P, McCall A, Hwang-Wong E, Rojas IG, Cormack B, Edgerton M. Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis. Plos Pathogens. 12: e1005522. PMID 27029023 DOI: 10.1371/Journal.Ppat.1005522 |
0.362 |
|
| 2016 |
Saraswat D, Kumar R, Pande T, Edgerton M, Cullen PJ. Signaling Mucin Msb2 Regulates Adaptation to Thermal Stress in Candida albicans. Molecular Microbiology. PMID 26749104 DOI: 10.1111/Mmi.13326 |
0.319 |
|
| 2016 |
Salvatori O, Puri S, Tati S, Edgerton M. Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases. Journal of Dental Research. PMID 26747422 DOI: 10.1177/0022034515625222 |
0.37 |
|
| 2016 |
Baker OJ, Edgerton M, Kramer JM, Ruhl S. Saliva-microbe interactions and salivary gland dysfunction. Advances in Dental Research. 26: 7-14. PMID 24736699 DOI: 10.1177/0022034514526239 |
0.413 |
|
| 2015 |
Puri S, Friedman J, Saraswat D, Kumar R, Li R, Ruszaj D, Edgerton M. Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5. Pathogens (Basel, Switzerland). 4: 752-63. PMID 26529023 DOI: 10.3390/Pathogens4040752 |
0.472 |
|
| 2015 |
Kumar R, Saraswat D, Tati S, Edgerton M. Novel aggregation properties of Candida albicans secreted aspartyl proteinase Sap6 mediates virulence in oral candidiasis. Infection and Immunity. PMID 25870228 DOI: 10.1128/Iai.00282-15 |
0.455 |
|
| 2015 |
Li R, Puri S, Tati S, Cullen PJ, Edgerton M. Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5. Antimicrobial Agents and Chemotherapy. 59: 3460-8. PMID 25824232 DOI: 10.1128/Aac.00214-15 |
0.413 |
|
| 2015 |
Puri S, Li R, Ruszaj D, Tati S, Edgerton M. Iron binding modulates candidacidal properties of salivary histatin 5. Journal of Dental Research. 94: 201-8. PMID 25365968 DOI: 10.1177/0022034514556709 |
0.324 |
|
| 2014 |
Puri S, Edgerton M. How does it kill?: understanding the candidacidal mechanism of salivary histatin 5. Eukaryotic Cell. 13: 958-64. PMID 24951439 DOI: 10.1128/Ec.00095-14 |
0.469 |
|
| 2014 |
Tati S, Li R, Puri S, Kumar R, Davidow P, Edgerton M. Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis. Antimicrobial Agents and Chemotherapy. 58: 756-66. PMID 24247141 DOI: 10.1128/Aac.01851-13 |
0.42 |
|
| 2013 |
Tati S, Jang WS, Li R, Kumar R, Puri S, Edgerton M. Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31. Plos One. 8: e61480. PMID 23613860 DOI: 10.1371/Journal.Pone.0061480 |
0.421 |
|
| 2013 |
Li R, Kumar R, Tati S, Puri S, Edgerton M. Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity. Antimicrobial Agents and Chemotherapy. 57: 1832-9. PMID 23380720 DOI: 10.1128/Aac.02295-12 |
0.473 |
|
| 2012 |
Puri S, Kumar R, Chadha S, Tati S, Conti HR, Hube B, Cullen PJ, Edgerton M. Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. Plos One. 7: e46020. PMID 23139737 DOI: 10.1371/Journal.Pone.0046020 |
0.402 |
|
| 2011 |
Kumar R, Chadha S, Saraswat D, Bajwa JS, Li RA, Conti HR, Edgerton M. Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins. The Journal of Biological Chemistry. 286: 43748-58. PMID 22033918 DOI: 10.1074/Jbc.M111.311175 |
0.441 |
|
| 2011 |
Pandiyan P, Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL, Lenardo MJ. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 34: 422-34. PMID 21435589 DOI: 10.1016/J.Immuni.2011.03.002 |
0.564 |
|
| 2011 |
Conti HR, Baker O, Freeman AF, Jang WS, Holland SM, Li RA, Edgerton M, Gaffen SL. New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. Mucosal Immunology. 4: 448-55. PMID 21346738 DOI: 10.1038/Mi.2011.5 |
0.582 |
|
| 2010 |
Sun JN, Solis NV, Phan QT, Bajwa JS, Kashleva H, Thompson A, Liu Y, Dongari-Bagtzoglou A, Edgerton M, Filler SG. Host cell invasion and virulence mediated by Candida albicans Ssa1. Plos Pathogens. 6: e1001181. PMID 21085601 DOI: 10.1371/Journal.Ppat.1001181 |
0.43 |
|
| 2010 |
Jang WS, Bajwa JS, Sun JN, Edgerton M. Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans. Molecular Microbiology. 77: 354-70. PMID 20487276 DOI: 10.1111/J.1365-2958.2010.07210.X |
0.456 |
|
| 2009 |
Pusateri CR, Monaco EA, Edgerton M. Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine. Archives of Oral Biology. 54: 588-94. PMID 19249746 DOI: 10.1016/J.Archoralbio.2009.01.016 |
0.421 |
|
| 2009 |
Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. The Journal of Experimental Medicine. 206: 299-311. PMID 19204111 DOI: 10.1084/Jem.20081463 |
0.54 |
|
| 2009 |
Miranda M, Bashi E, Vylkova S, Edgerton M, Slayman C, Rivetta A. Conservation and dispersion of sequence and function in fungal TRK potassium transporters: Focus on Candida albicans Fems Yeast Research. 9: 278-292. PMID 19175416 DOI: 10.1111/J.1567-1364.2008.00471.X |
0.717 |
|
| 2008 |
Sun JN, Li W, Jang WS, Nayyar N, Sutton MD, Edgerton M. Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domain. Molecular Microbiology. 70: 1246-60. PMID 19006817 DOI: 10.1111/J.1365-2958.2008.06480.X |
0.408 |
|
| 2008 |
Jang WS, Li XS, Sun JN, Edgerton M. The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding. Antimicrobial Agents and Chemotherapy. 52: 497-504. PMID 17999963 DOI: 10.1128/Aac.01199-07 |
0.424 |
|
| 2008 |
Conti HR, Shen F, Nayyar N, Stocum E, Lindemann MJ, Ho A, Masso-Welch P, Edgerton M, Gaffen SL. 52 Defining host T-cell responses in oral candidiasis Cytokine. 43: 249. DOI: 10.1016/J.Cyto.2008.07.093 |
0.551 |
|
| 2007 |
Vylkova S, Sun JN, Edgerton M. The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides. Purinergic Signalling. 3: 91-7. PMID 18404422 DOI: 10.1007/S11302-006-9040-0 |
0.715 |
|
| 2007 |
Vylkova S, Jang WS, Li W, Nayyar N, Edgerton M. Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway. Eukaryotic Cell. 6: 1876-88. PMID 17715369 DOI: 10.1128/Ec.00039-07 |
0.707 |
|
| 2007 |
Vylkova S, Nayyar N, Li W, Edgerton M. Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption. Antimicrobial Agents and Chemotherapy. 51: 154-61. PMID 17074797 DOI: 10.1128/Aac.00478-06 |
0.736 |
|
| 2006 |
Li XS, Sun JN, Okamoto-Shibayama K, Edgerton M. Candida albicans cell wall ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity. The Journal of Biological Chemistry. 281: 22453-63. PMID 16720580 DOI: 10.1074/Jbc.M604064200 |
0.448 |
|
| 2006 |
Vylkova S, Li XS, Berner JC, Edgerton M. Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides. Antimicrobial Agents and Chemotherapy. 50: 324-31. PMID 16377704 DOI: 10.1128/Aac.50.1.324-331.2006 |
0.722 |
|
| 2004 |
Baev D, Rivetta A, Vylkova S, Sun JN, Zeng GF, Slayman CL, Edgerton M. The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5. The Journal of Biological Chemistry. 279: 55060-72. PMID 15485849 DOI: 10.1074/Jbc.M411031200 |
0.731 |
|
| 2004 |
Wunder D, Dong J, Baev D, Edgerton M. Human salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicans. Antimicrobial Agents and Chemotherapy. 48: 110-5. PMID 14693527 DOI: 10.1128/Aac.48.1.110-115.2004 |
0.417 |
|
| 2003 |
Dong J, Vylkova S, Li XS, Edgerton M. Calcium blocks fungicidal activity of human salivary histatin 5 through disruption of binding with Candida albicans. Journal of Dental Research. 82: 748-52. PMID 12939362 DOI: 10.1177/154405910308200917 |
0.724 |
|
| 2003 |
Li XS, Reddy MS, Baev D, Edgerton M. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. The Journal of Biological Chemistry. 278: 28553-61. PMID 12761219 DOI: 10.1074/Jbc.M300680200 |
0.429 |
|
| 2003 |
Baev D, Rivetta A, Li XS, Vylkova S, Bashi E, Slayman CL, Edgerton M. Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. Infection and Immunity. 71: 3251-60. PMID 12761106 DOI: 10.1128/Iai.71.6.3251-3260.2003 |
0.712 |
|
| 2002 |
Baev D, Li XS, Dong J, Keng P, Edgerton M. Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans. Infection and Immunity. 70: 4777-84. PMID 12183519 DOI: 10.1128/Iai.70.9.4777-4784.2002 |
0.445 |
|
| 2001 |
Baev D, Li X, Edgerton M. Genetically engineered human salivary histatin genes are functional in Candida albicans: development of a new system for studying histatin candidacidal activity. Microbiology (Reading, England). 147: 3323-34. PMID 11739764 DOI: 10.1099/00221287-147-12-3323 |
0.622 |
|
| 2000 |
Edgerton M, Koshlukova SE. Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva Advances in Dental Research. 14: 16-21. PMID 2002142310 DOI: 10.1177/08959374000140010201 |
0.432 |
|
| 2000 |
Koshlukova SE, Araujo MWB, Baev D, Edgerton M. Released ATP is an extracellular cytotoxic mediator in salivary histatin 5-induced killing of Candida albicans Infection and Immunity. 68: 6848-6856. PMID 11083804 DOI: 10.1128/Iai.68.12.6848-6856.2000 |
0.43 |
|
| 2000 |
Edgerton M, Koshlukova SE, Araujo MWB, Patel RC, Dong J, Bruenn JA. Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways Antimicrobial Agents and Chemotherapy. 44: 3310-3316. PMID 11083633 DOI: 10.1128/Aac.44.12.3310-3316.2000 |
0.485 |
|
| 1999 |
Koshlukova SE, Lloyd TL, Araujo MWB, Edgerton M. Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death Journal of Biological Chemistry. 274: 18872-18879. PMID 10383383 DOI: 10.1074/Jbc.274.27.18872 |
0.434 |
|
| 1998 |
Edgerton M, Koshlukova SE, Lo TE, Chrzan BG, Straubinger RM, Raj PA. Candidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicans. The Journal of Biological Chemistry. 273: 20438-47. PMID 9685398 DOI: 10.1074/Jbc.273.32.20438 |
0.665 |
|
| 1996 |
Raj PA, Marcus E, Edgerton M. Delineation of an active fragment and poly(L-proline) II conformation for candidacidal activity of bactenecin 5 Biochemistry. 35: 4314-4325. PMID 8605180 DOI: 10.1021/Bi951681R |
0.325 |
|
| 1995 |
Edgerton M, Raj PA, Levine MJ. Surface‐modified poly(methyl methacrylate) enhances adsorption and retains anticandidal activities of salivary histatin 5 Journal of Biomedical Materials Research. 29: 1277-1286. PMID 8557730 DOI: 10.1002/Jbm.820291015 |
0.336 |
|
| 1993 |
Edgerton M, Scannapieco FA, Reddy MS, Levine MJ. Human submandibular-sublingual saliva promotes adhesion of Candida albicans to polymethylmethacrylate Infection and Immunity. 61: 2644-2652. PMID 8500903 DOI: 10.1128/Iai.61.6.2644-2652.1993 |
0.355 |
|
| 1992 |
Edgerton M, Levine MJ. Characterization of acquired denture pellicle from healthy and stomatitis patients The Journal of Prosthetic Dentistry. 68: 683-691. PMID 1403950 DOI: 10.1016/0022-3913(92)90387-P |
0.363 |
|
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