Ira S. Cohen, Ph.D., M.D. - Publications

Affiliations: 
Physiology and Biophysics Stony Brook University, Stony Brook, NY, United States 
Area:
Cardiac Myocytes
Website:
http://pnb.informatics.stonybrook.edu/faculty/cohen.shtml

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, ... ... Cohen IS, et al. Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33990467 DOI: 10.1073/pnas.2024215118  0.307
2020 Lu MK, Gordon C, Zuckerman J, Brink P, Cohen I. MicroRNAs Contribute to Angiotensin II‐Mediated Regulation of Transmural Electrical Remodeling in the Heart The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08866  0.307
2019 Lin RZ, Lu Z, Anyukhovsky EP, Jiang YP, Wang HZ, Gao J, Rosen MR, Ballou LM, Cohen IS. Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling. The Journal of General Physiology. PMID 31217223 DOI: 10.1085/Jgp.201812293  0.362
2019 Liu Y, Xu X, Naffaa MM, Liang H, Zhang G, Hou P, Wang H, Gao J, Shi J, Cohen I, Zou X, Cui J. CP1 Is a Potent IKs Channel Activator Which Acts by Substituting Phosphatidylinositol 4,5 Bisphosphate Biophysical Journal. 116: 542a-543a. DOI: 10.1016/J.Bpj.2018.11.2916  0.336
2017 Valiunas V, Cohen IS, Brink PR. Defining the factors that affect solute permeation of gap junction channels. Biochimica Et Biophysica Acta. PMID 28690048 DOI: 10.1016/J.Bbamem.2017.07.002  0.347
2017 Kim JH, Jiang YP, Cohen IS, Lin RZ, Mathias RT. Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart. Plos One. 12: e0176713. PMID 28464037 DOI: 10.1371/Journal.Pone.0176713  0.355
2017 Naffaa MM, Xu X, Liang H, Zhang G, Zhan Wang H, Goa J, Cohen IS, Zou X, Cui J. CP1 Opens I Ks Channels by Substituting PIP 2 Biophysical Journal. 112: 110a. DOI: 10.1016/J.Bpj.2016.11.623  0.432
2016 Qiu XS, Chauveau S, Anyukhovsky EP, Rahim T, Jiang YP, Harleton E, Feinmark SJ, Lin RZ, Coronel R, Janse MJ, Opthof T, Rosen TS, Cohen IS, Rosen MR. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27071826 DOI: 10.1161/Circep.115.003655  0.313
2016 Chauveau S, Anyukhovskiy Y, Benari M, Naor S, Danilo P, Rahim T, Potapova I, Burke S, Jiang Y, Qiu X, Brink P, Binah B, Cohen I, Rosen M. 0406 : Keratinocyte-derived cardiomyocytes provide in vivo biological pacemaker function Archives of Cardiovascular Diseases Supplements. 8: 257. DOI: 10.1016/S1878-6480(16)30505-5  0.357
2015 Kim J, Gao J, Cohen IS, Mathias RT. Angiotensin II Type 1 Receptor-Mediated Electrical Remodeling in Mouse Cardiac Myocytes. Plos One. 10: e0138711. PMID 26430746 DOI: 10.1371/Journal.Pone.0138711  0.336
2015 Wang HZ, Rosati B, Gordon C, Valiunas V, McKinnon D, Cohen IS, Brink PR. Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells. Frontiers in Pharmacology. 6: 9. PMID 25691868 DOI: 10.3389/Fphar.2015.00009  0.6
2015 Valiunas V, Wang HZ, Li L, Gordon C, Valiuniene L, Cohen IS, Brink PR. A comparison of two cellular delivery mechanisms for small interfering RNA. Physiological Reports. 3. PMID 25649248 DOI: 10.14814/Phy2.12286  0.318
2015 Ballou LM, Lin RZ, Cohen IS. Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels. Circulation Research. 116: 127-37. PMID 25552692 DOI: 10.1161/Circresaha.116.303975  0.37
2014 Gao J, Sun X, Potapova IA, Cohen IS, Mathias RT, Kim JH. Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load? Biophysical Journal. 106: 2364-74. PMID 24896115 DOI: 10.1016/J.Bpj.2014.04.042  0.3
2014 Chauveau S, Brink PR, Cohen IS. Stem cell-based biological pacemakers from proof of principle to therapy: a review. Cytotherapy. 16: 873-80. PMID 24831844 DOI: 10.1016/J.Jcyt.2014.02.014  0.327
2014 Zaydman MA, Li Y, Beller Z, Wu D, Rong H, Silva JR, Delaloye K, Shi J, Cohen I, Cui J. Dynamic Pip2-Iks Interactions Mediate Cardiac Rate Adaptation Biophysical Journal. 106: 749a-750a. DOI: 10.1016/J.Bpj.2013.11.4128  0.393
2013 Li Y, Gao J, Lu Z, McFarland K, Shi J, Bock K, Cohen IS, Cui J. Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks). Proceedings of the National Academy of Sciences of the United States of America. 110: 18922-7. PMID 24190995 DOI: 10.1073/Pnas.1315649110  0.39
2013 Williams JC, Xu J, Lu Z, Klimas A, Chen X, Ambrosi CM, Cohen IS, Entcheva E. Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model. Plos Computational Biology. 9: e1003220. PMID 24068903 DOI: 10.1371/Journal.Pcbi.1003220  0.385
2013 Kaufman J, Gordon C, Bergamaschi R, Wang HZ, Cohen IS, Valiunas V, Brink PR. The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability. Frontiers in Pharmacology. 4: 111. PMID 24027526 DOI: 10.3389/Fphar.2013.00111  0.397
2013 Clausen C, Valiunas V, Brink PR, Cohen IS. MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C. PflüGers Archiv : European Journal of Physiology. 465: 497-507. PMID 23224681 DOI: 10.1007/S00424-012-1186-8  0.325
2012 Özgen N, Lu Z, Boink GJ, Lau DH, Shlapakova IN, Bobkov Y, Danilo P, Cohen IS, Rosen MR. Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 1865-72. PMID 22820054 DOI: 10.1016/J.Hrthm.2012.07.014  0.41
2012 Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P, Robinson RB, Verrier RL, Rosen MR. Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation. 126: 528-36. PMID 22753192 DOI: 10.1161/Circulationaha.111.083584  0.31
2012 Boink GJ, Lu J, Driessen HE, Duan L, Sosunov EA, Anyukhovsky EP, Shlapakova IN, Lau DH, Rosen TS, Danilo P, Jia Z, Ozgen N, Bobkov Y, Guo Y, Brink PR, ... ... Cohen IS, et al. Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction. Circulation. Arrhythmia and Electrophysiology. 5: 831-40. PMID 22722661 DOI: 10.1161/Circep.111.969907  0.423
2012 Lu Z, Wu CY, Jiang YP, Ballou LM, Clausen C, Cohen IS, Lin RZ. Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. Science Translational Medicine. 4: 131ra50. PMID 22539774 DOI: 10.1126/Scitranslmed.3003623  0.38
2012 Lu J, Wang HZ, Jia Z, Zuckerman J, Lu Z, Guo Y, Boink GJ, Brink PR, Robinson RB, Entcheva E, Cohen IS. Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy. Journal of Cardiovascular Pharmacology. 60: 88-99. PMID 22526298 DOI: 10.1097/Fjc.0B013E3182588B00  0.458
2012 Boink GJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P, Rosen TS, ?zgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, ... ... Cohen IS, et al. SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic. Cardiovascular Research. 94: 450-9. PMID 22374989 DOI: 10.1093/Cvr/Cvs107  0.335
2012 Valiunas V, Clausen C, Butz R, Valiuniene L, Rosen MR, Brink PR, Cohen IS. The Dynamic Clamp Induced Pacing in Single and Coupled Cells Biophysical Journal. 102: 108a-109a. DOI: 10.1016/J.Bpj.2011.11.610  0.364
2011 Jia Z, Valiunas V, Lu Z, Bien H, Liu H, Wang HZ, Rosati B, Brink PR, Cohen IS, Entcheva E. Stimulating cardiac muscle by light: cardiac optogenetics by cell delivery. Circulation. Arrhythmia and Electrophysiology. 4: 753-60. PMID 21828312 DOI: 10.1161/Circep.111.964247  0.345
2011 Lu Z, Ballou LM, Jiang YP, Cohen IS, Lin RZ. Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-ι. Journal of Cardiovascular Pharmacology. 58: 439-45. PMID 21753738 DOI: 10.1097/Fjc.0B013E318228E68C  0.356
2010 Coronel R, Lau DH, Sosunov EA, Janse MJ, Danilo P, Anyukhovsky EP, Wilms-Schopman FJ, Opthof T, Shlapakova IN, Ozgen N, Prestia K, Kryukova Y, Cohen IS, Robinson RB, Rosen MR. Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 7: 1104-10. PMID 20385252 DOI: 10.1016/J.Hrthm.2010.04.009  0.398
2009 Kelly DJ, Rosen AB, Schuldt AJ, Kochupura PV, Doronin SV, Potapova IA, Azeloglu EU, Badylak SF, Brink PR, Cohen IS, Gaudette GR. Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation. Tissue Engineering. Part A. 15: 2189-201. PMID 19231971 DOI: 10.1089/Ten.Tea.2008.0430  0.605
2009 Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, et al. Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study. Circulation. 119: 19-27. PMID 19103989 DOI: 10.1161/Circulationaha.108.809301  0.407
2009 Protas L, Dun W, Jia Z, Lu J, Bucchi A, Kumari S, Chen M, Cohen IS, Rosen MR, Entcheva E, Robinson RB. Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. Cardiovascular Research. 81: 528-35. PMID 18977767 DOI: 10.1093/Cvr/Cvn290  0.433
2008 Potapova IA, Doronin SV, Kelly DJ, Rosen AB, Schuldt AJ, Lu Z, Kochupura PV, Robinson RB, Rosen MR, Brink PR, Gaudette GR, Cohen IS. Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage. American Journal of Physiology. Heart and Circulatory Physiology. 295: H2257-63. PMID 18835924 DOI: 10.1152/Ajpheart.00219.2008  0.653
2008 Rosen MR, Brink PR, Cohen IS, Danilo P, Robinson RB, Rosen AB, Szabolcs MJ. Regenerative therapies in electrophysiology and pacing. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. 22: 87-98. PMID 18363088 DOI: 10.1007/S10840-008-9208-3  0.319
2008 Potapova IA, Brink PR, Cohen IS, Doronin SV. Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. The Journal of Biological Chemistry. 283: 13100-7. PMID 18334485 DOI: 10.1074/Jbc.M800184200  0.303
2008 Schuldt AJ, Rosen MR, Gaudette GR, Cohen IS. Repairing damaged myocardium: evaluating cells used for cardiac regeneration. Current Treatment Options in Cardiovascular Medicine. 10: 59-72. PMID 18325308 DOI: 10.1007/S11936-008-0007-Z  0.362
2008 Plotnikov AN, Bucchi A, Shlapakova I, Danilo P, Brink PR, Robinson RB, Cohen IS, Rosen MR. HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 5: 282-8. PMID 18242555 DOI: 10.1016/J.Hrthm.2007.09.028  0.371
2007 Potapova IA, Doronin SV, Kelly DJ, Rosen AB, Schuldt AJ, Lu Z, Guo Y, Kochupura PV, Robinson RB, Rosen MR, Brink PR, Gaudette GR, Cohen IS. Replacing damaged myocardium. Journal of Electrocardiology. 40: S199-201. PMID 17993323 DOI: 10.1016/J.Jelectrocard.2007.05.025  0.627
2007 Lu Z, Gao J, Zuckerman J, Mathias RT, Gaudette G, Krukenkamp I, Cohen IS. Two-pore K+ channels, NO and metabolic inhibition. Biochemical and Biophysical Research Communications. 363: 194-6. PMID 17826741 DOI: 10.1016/J.Bbrc.2007.08.131  0.38
2007 Potapova IA, Cohen IS, Doronin SV. Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. The Febs Journal. 274: 4375-84. PMID 17725712 DOI: 10.1111/J.1742-4658.2007.05966.X  0.345
2007 Lu Z, Jiang YP, Xu XH, Ballou LM, Cohen IS, Lin RZ. Decreased L-type Ca2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling. Diabetes. 56: 2780-9. PMID 17666471 DOI: 10.2337/Db06-1629  0.312
2007 Plotnikov AN, Shlapakova I, Szabolcs MJ, Danilo P, Lorell BH, Potapova IA, Lu Z, Rosen AB, Mathias RT, Brink PR, Robinson RB, Cohen IS, Rosen MR. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation. 116: 706-13. PMID 17646577 DOI: 10.1161/Circulationaha.107.703231  0.35
2007 Rosen MR, Brink PR, Cohen IS, Robinson RB. Biological pacemakers based on I(f). Medical & Biological Engineering & Computing. 45: 157-66. PMID 17629762 DOI: 10.1007/S11517-006-0060-2  0.395
2007 Rosen AB, Kelly DJ, Schuldt AJ, Lu J, Potapova IA, Doronin SV, Robichaud KJ, Robinson RB, Rosen MR, Brink PR, Gaudette GR, Cohen IS. Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis. Stem Cells (Dayton, Ohio). 25: 2128-38. PMID 17495112 DOI: 10.1634/Stemcells.2006-0722  0.59
2007 Cohen IS, Rosen AB, Gaudette GR. A Caveat Emptor for myocardial regeneration: mechanical without electrical recovery will not suffice. Journal of Molecular and Cellular Cardiology. 42: 285-8. PMID 17196613 DOI: 10.1016/J.Yjmcc.2006.11.001  0.362
2006 Badylak SF, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW, Kelly DJ, Ignotz RA, Gaudette GR. The Use of Extracellular Matrix as an Inductive Scaffold for the Partial Replacement of Functional Myocardium. Cell Transplantation. 15: 29-40. PMID 28863772 DOI: 10.3727/000000006783982368  0.554
2006 Bucchi A, Plotnikov AN, Shlapakova I, Danilo P, Kryukova Y, Qu J, Lu Z, Liu H, Pan Z, Potapova I, KenKnight B, Girouard S, Cohen IS, Brink PR, Robinson RB, et al. Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker. Circulation. 114: 992-9. PMID 16923750 DOI: 10.1161/Circulationaha.106.617613  0.387
2006 Jiang YP, Ballou LM, Lu Z, Li Wan, Kelly DJ, Cohen IS, Lin RZ. Reversible heart failure in G alpha(q) transgenic mice. The Journal of Biological Chemistry. 281: 29988-92. PMID 16893886 DOI: 10.1074/Jbc.M604699200  0.623
2006 Badylak SF, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW, Kelly DJ, Ignotz RA, Gaudette GR. The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium. Cell Transplantation. 15: S29-40. PMID 16826793 DOI: 10.3727/000000006783982368  0.595
2006 Arinsburg SS, Cohen IS, Yu HG. Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins. Journal of Cardiovascular Pharmacology. 47: 578-86. PMID 16680072 DOI: 10.1097/01.Fjc.0000211740.47960.8B  0.369
2006 Robinson RB, Brink PR, Cohen IS, Rosen MR. I(f) and the biological pacemaker. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 53: 407-15. PMID 16621592 DOI: 10.1016/J.Phrs.2006.03.007  0.336
2006 Rosen MR, Cohen IS. Cardiac memory ... new insights into molecular mechanisms. The Journal of Physiology. 570: 209-18. PMID 16284076 DOI: 10.1113/Jphysiol.2005.097873  0.341
2005 Fan G, Jiang YP, Lu Z, Martin DW, Kelly DJ, Zuckerman JM, Ballou LM, Cohen IS, Lin RZ. A transgenic mouse model of heart failure using inducible Galpha q. The Journal of Biological Chemistry. 280: 40337-46. PMID 16210321 DOI: 10.1074/Jbc.M506810200  0.614
2005 Lu Z, Jiang YP, Ballou LM, Cohen IS, Lin RZ. Galpha q inhibits cardiac L-type Ca2+ channels through phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 280: 40347-54. PMID 16186103 DOI: 10.1074/Jbc.M508441200  0.32
2005 Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR. Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function. Circulation. 112: I144-9. PMID 16159807 DOI: 10.1161/Circulationaha.104.524355  0.596
2005 Gao J, Wang W, Cohen IS, Mathias RT. Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle. Biophysical Journal. 89: 1700-9. PMID 16127169 DOI: 10.1529/Biophysj.105.062406  0.345
2005 Robinson RB, Rosen MR, Brink PR, Cohen IS. Letter regarding the article by Xue et al, "Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes". Circulation. 112: e82; author reply e8. PMID 16087804 DOI: 10.1161/Circulationaha.104.534214  0.357
2005 Valiunas V, Polosina YY, Miller H, Potapova IA, Valiuniene L, Doronin S, Mathias RT, Robinson RB, Rosen MR, Cohen IS, Brink PR. Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. The Journal of Physiology. 568: 459-68. PMID 16037090 DOI: 10.1113/Jphysiol.2005.090985  0.313
2004 Rosen MR, Robinson RB, Brink P, Cohen IS. Recreating the biological pacemaker. The Anatomical Record. Part a, Discoveries in Molecular, Cellular, and Evolutionary Biology. 280: 1046-52. PMID 15372435 DOI: 10.1002/Ar.A.20073  0.308
2004 Rosen MR, Brink PR, Cohen IS, Robinson RB. Genes, stem cells and biological pacemakers. Cardiovascular Research. 64: 12-23. PMID 15364609 DOI: 10.1016/J.Cardiores.2004.05.012  0.349
2004 Doronin SV, Potapova IA, Lu Z, Cohen IS. Angiotensin receptor type 1 forms a complex with the transient outward potassium channel Kv4.3 and regulates its gating properties and intracellular localization. The Journal of Biological Chemistry. 279: 48231-7. PMID 15342638 DOI: 10.1074/Jbc.M405789200  0.339
2004 Qu J, Kryukova Y, Potapova IA, Doronin SV, Larsen M, Krishnamurthy G, Cohen IS, Robinson RB. MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes. The Journal of Biological Chemistry. 279: 43497-502. PMID 15292247 DOI: 10.1074/Jbc.M405018200  0.442
2004 Potapova I, Plotnikov A, Lu Z, Danilo P, Valiunas V, Qu J, Doronin S, Zuckerman J, Shlapakova IN, Gao J, Pan Z, Herron AJ, Robinson RB, Brink PR, Rosen MR, ... Cohen IS, et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circulation Research. 94: 952-9. PMID 14988226 DOI: 10.1161/01.Res.0000123827.60210.72  0.445
2004 Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, Robinson RB, Rosen MR, Brink PR, Cohen IS. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. The Journal of Physiology. 555: 617-26. PMID 14766937 DOI: 10.1113/Jphysiol.2003.058719  0.4
2004 Plotnikov AN, Sosunov EA, Qu J, Shlapakova IN, Anyukhovsky EP, Liu L, Janse MJ, Brink PR, Cohen IS, Robinson RB, Danilo P, Rosen MR. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation. 109: 506-12. PMID 14734518 DOI: 10.1161/01.Cir.0000114527.10764.Cc  0.359
2004 Yu HG, Lu Z, Pan Z, Cohen IS. Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. PflüGers Archiv : European Journal of Physiology. 447: 392-400. PMID 14634823 DOI: 10.1007/S00424-003-1204-Y  0.436
2003 Irie H, Gao J, Gaudette GR, Cohen IS, Mathias RT, Saltman AE, Krukenkamp IB. Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current. Circulation. 108: II341-7. PMID 12970257 DOI: 10.1161/01.Cir.0000087431.91602.E2  0.41
2003 Plotnikov AN, Yu H, Geller JC, Gainullin RZ, Chandra P, Patberg KW, Friezema S, Danilo P, Cohen IS, Feinmark SJ, Rosen MR. Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart. Circulation. 107: 2844-9. PMID 12756152 DOI: 10.1161/01.Cir.0000068376.88600.41  0.338
2003 Qu J, Plotnikov AN, Danilo P, Shlapakova I, Cohen IS, Robinson RB, Rosen MR. Expression and function of a biological pacemaker in canine heart. Circulation. 107: 1106-9. PMID 12615786 DOI: 10.1161/01.Cir.0000059939.97249.2C  0.384
2003 Wang HS, Cohen IS. Calcium channel heterogeneity in canine left ventricular myocytes. The Journal of Physiology. 547: 825-33. PMID 12562927 DOI: 10.1111/J..2003.T01-1-00825.X  0.565
2002 Gao J, Wymore RS, Wang Y, Gaudette GR, Krukenkamp IB, Cohen IS, Mathias RT. Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. The Journal of General Physiology. 119: 297-312. PMID 11929882 DOI: 10.1085/Jgp.20028501  0.319
2002 Gaudette GR, Gao J, Cohen IS, Mathias RT, Zuckerman J, Irie H, Saltman AE, Krukenkamp IB. Ischemic preconditioning protects the heart from membrane current changes due to ischemia Journal of the American College of Cardiology. 39: 323-324. DOI: 10.1016/S0735-1097(02)81455-3  0.319
2001 Qu J, Barbuti A, Protas L, Santoro B, Cohen IS, Robinson RB. HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circulation Research. 89: E8-14. PMID 11440985 DOI: 10.1161/Hh1301.094395  0.37
2001 Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H, Shi W, Robinson RB, El-Maghrabi MR, Benjamin W, Dixon J, McKinnon D, Cohen IS, et al. MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circulation Research. 88: E84-7. PMID 11420311 DOI: 10.1161/Hh1201.093511  0.681
2001 Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. The Journal of Physiology. 533: 119-25. PMID 11351020 DOI: 10.1111/J.1469-7793.2001.0119B.X  0.701
2000 Qu J, Cohen IS, Robinson RB. Sympathetic innervation alters activation of pacemaker current (If) in rat ventricle. The Journal of Physiology. 526: 561-9. PMID 10922008 DOI: 10.1111/J.1469-7793.2000.T01-1-00561.X  0.349
2000 Yu H, Gao J, Wang H, Wymore R, Steinberg S, McKinnon D, Rosen MR, Cohen IS. Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circulation Research. 86: 1062-8. PMID 10827136 DOI: 10.1161/01.Res.86.10.1062  0.683
2000 Wang HS, Brown BS, McKinnon D, Cohen IS. Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991. Molecular Pharmacology. 57: 1218-23. PMID 10825393  0.672
1999 Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circulation Research. 85: e1-6. PMID 10400919 DOI: 10.1161/01.Res.85.1.E1  0.619
1999 Yu H, McKinnon D, Dixon JE, Gao J, Wymore R, Cohen IS, Danilo P, Shvilkin A, Anyukhovsky EP, Sosunov EA, Hara M, Rosen MR. Transient outward current, Ito1, is altered in cardiac memory. Circulation. 99: 1898-905. PMID 10199889 DOI: 10.1161/01.Cir.99.14.1898  0.607
1999 Gao J, Wymore R, Wymore RT, Wang Y, McKinnon D, Dixon JE, Mathias RT, Cohen IS, Baldo GJ. Isoform-specific regulation of the sodium pump by alpha- and beta-adrenergic agonists in the guinea-pig ventricle. The Journal of Physiology. 516: 377-83. PMID 10087338 DOI: 10.1111/J.1469-7793.1999.0377V.X  0.575
1999 Gao J, Mathias RT, Cohen IS, Wang Y, Sun X, Baldo GJ. Activation of PKC increases Na+-K+ pump current in ventricular myocytes from guinea pig heart. PflüGers Archiv : European Journal of Physiology. 437: 643-51. PMID 10087140 DOI: 10.1007/S004240050828  0.34
1998 Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science (New York, N.Y.). 282: 1890-3. PMID 9836639 DOI: 10.1126/Science.282.5395.1890  0.671
1998 Shi W, Wang HS, Pan Z, Wymore RS, Cohen IS, McKinnon D, Dixon JE. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. The Journal of Physiology. 511: 675-82. PMID 9714851 DOI: 10.1111/J.1469-7793.1998.675Bg.X  0.669
1998 Wang Y, Gao J, Mathias RT, Cohen IS, Sun X, Baldo GJ. alpha-Adrenergic effects on Na+-K+ pump current in guinea-pig ventricular myocytes. The Journal of Physiology. 509: 117-28. PMID 9547386 DOI: 10.1111/J.1469-7793.1998.117Bo.X  0.336
1998 Gao J, Cohen IS, Mathias RT, Baldo GJ. The inhibitory effect of beta-stimulation on the Na/K pump current in guinea pig ventricular myocytes is mediated by a cAMP-dependent PKA pathway. PflüGers Archiv : European Journal of Physiology. 435: 479-84. PMID 9446694 DOI: 10.1007/S004240050542  0.332
1997 Hara M, Liu YM, Zhen L, Cohen IS, Yu H, Danilo P, Ogino K, Bilezikian JP, Rosen MR. Positive chronotropic actions of parathyroid hormone and parathyroid hormone-related peptide are associated with increases in the current, I(f), and the slope of the pacemaker potential. Circulation. 96: 3704-9. PMID 9396474 DOI: 10.1161/01.Cir.96.10.3704  0.321
1997 Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE. Identification of two nervous system-specific members of the erg potassium channel gene family. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9423-32. PMID 9390998  0.646
1997 Gao J, Mathias RT, Cohen IS, Baldo GJ. Effects of acetylcholine on the Na(+)-K+ pump current in guinea-pig ventricular myocytes. The Journal of Physiology. 501: 527-35. PMID 9218213 DOI: 10.1111/J.1469-7793.1997.527Bm.X  0.353
1997 Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circulation Research. 80: 261-8. PMID 9012748 DOI: 10.1161/01.Res.80.2.261  0.642
1997 Robinson RB, Yu H, Chang F, Cohen IS. Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells. PflüGers Archiv : European Journal of Physiology. 433: 533-5. PMID 9000433 DOI: 10.1007/S004240050309  0.354
1997 Shi W, Wymore RS, Wang H, Pan Z, Cohen IS, McKinnon D, Dixon JE. Identification of Two Nervous System-Specific Members of theerg Potassium Channel Gene Family The Journal of Neuroscience. 17: 9423-9432. DOI: 10.1523/Jneurosci.17-24-09423.1997  0.67
1996 Gao J, Mathias RT, Cohen IS, Shi J, Baldo GJ. The effects of beta-stimulation on the Na(+)-K+ pump current-voltage relationship in guinea-pig ventricular myocytes. The Journal of Physiology. 494: 697-708. PMID 8865067 DOI: 10.1113/Jphysiol.1996.Sp021525  0.358
1996 Dixon JE, Shi W, Wang HS, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D. Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circulation Research. 79: 659-68. PMID 8831489 DOI: 10.1161/01.Res.79.4.659  0.712
1996 Charpentier F, Legato MJ, Steinberg SF, Cohen IS, Rosen MR. Beta-adrenergic modulation of Na-K pump activity in young and adult canine cardiac Purkinje fibers. The American Journal of Physiology. 271: H706-12. PMID 8770114 DOI: 10.1152/Ajpheart.1996.271.2.H706  0.306
1995 Vassalle M, Yu H, Cohen IS. The pacemaker current in cardiac Purkinje myocytes. The Journal of General Physiology. 106: 559-78. PMID 8786348 DOI: 10.1085/Jgp.106.3.559  0.374
1995 Gao J, Mathias RT, Cohen IS, Baldo GJ. Two functionally different Na/K pumps in cardiac ventricular myocytes. The Journal of General Physiology. 106: 995-1030. PMID 8648301 DOI: 10.1085/Jgp.106.5.995  0.35
1995 Tromba C, Cohen IS. Effects of potassium channel openers on Na+ and K+ currents in rabbit sinus node and atrial myocytes. Biochimica Et Biophysica Acta. 1266: 268-72. PMID 7766713 DOI: 10.1016/0167-4889(95)00036-R  0.431
1995 Yu H, Chang F, Cohen IS. Pacemaker current i(f) in adult canine cardiac ventricular myocytes. The Journal of Physiology. 485: 469-83. PMID 7545232 DOI: 10.1113/Jphysiol.1995.Sp020743  0.375
1994 Cui J, Kline RP, Pennefather P, Cohen IS. Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injected. The Journal of General Physiology. 104: 87-105. PMID 7964597 DOI: 10.1085/Jgp.104.1.87  0.386
1994 Gao J, Cohen IS, Mathias RT, Baldo GJ. Regulation of the beta-stimulation of the Na(+)-K+ pump current in guinea-pig ventricular myocytes by a cAMP-dependent PKA pathway. The Journal of Physiology. 477: 373-80. PMID 7932227 DOI: 10.1113/Jphysiol.1994.Sp020199  0.324
1994 Anyukhovsky EP, Steinberg SF, Cohen IS, Rosen MR. Receptor-effector coupling pathway for alpha 1-adrenergic modulation of abnormal automaticity in 'ischemic' canine Purkinje fibers. Circulation Research. 74: 937-44. PMID 7908861 DOI: 10.1161/01.Res.74.5.937  0.315
1994 Shvilkin A, Danilo P, Chevalier P, Chang F, Cohen IS, Rosen MR. Vagal release of vasoactive intestinal peptide can promote vagotonic tachycardia in the isolated innervated rat heart. Cardiovascular Research. 28: 1769-73. PMID 7867028 DOI: 10.1093/Cvr/28.12.1769  0.311
1993 Datyner NB, Cohen IS. Slow inactivation of L-type calcium current distorts the measurement of L- and T-type calcium current in Purkinje myocytes. The Journal of General Physiology. 102: 859-69. PMID 8301260 DOI: 10.1085/Jgp.102.5.859  0.319
1993 Yu H, Chang F, Cohen IS. Pacemaker current exists in ventricular myocytes. Circulation Research. 72: 232-6. PMID 7678078 DOI: 10.1161/01.Res.72.1.232  0.428
1992 Chang F, Cohen IS. Mechanism of acetylcholine action on pacemaker current (i(f)) in canine Purkinje fibers. PflüGers Archiv : European Journal of Physiology. 420: 389-92. PMID 1375991 DOI: 10.1007/Bf00374474  0.306
1992 Cui J, Mandel G, DiFrancesco D, Kline RP, Pennefather P, Datyner NB, Haspel HC, Cohen IS. Expression and characterization of a canine hippocampal inwardly rectifying K+ current in Xenopus oocytes. The Journal of Physiology. 457: 229-46. PMID 1338458 DOI: 10.1113/Jphysiol.1992.Sp019375  0.371
1992 Gao J, Mathias RT, Cohen IS, Baldo GJ. Isoprenaline, Ca2+ and the Na(+)-K+ pump in guinea-pig ventricular myocytes. The Journal of Physiology. 449: 689-704. PMID 1326051 DOI: 10.1113/Jphysiol.1992.Sp019109  0.353
1990 Tromba C, Cohen IS. A novel action of isoproterenol to inactivate a cardiac K+ current is not blocked by beta and alpha adrenergic blockers. Biophysical Journal. 58: 791-5. PMID 2207265 DOI: 10.1016/S0006-3495(90)82422-X  0.339
1990 Mathias RT, Cohen IS, Oliva C. Limitations of the whole cell patch clamp technique in the control of intracellular concentrations. Biophysical Journal. 58: 759-70. PMID 2169920 DOI: 10.1016/S0006-3495(90)82418-8  0.303
1990 Kline RP, Zablow L, Cohen IS. Interaction of intracellular ion buffering with transmembrane-coupled ion transport. The Journal of General Physiology. 95: 499-522. PMID 2157793 DOI: 10.1085/Jgp.95.3.499  0.324
1990 Chang F, Gao J, Tromba C, Cohen I, DiFrancesco D. Acetylcholine reverses effects of beta-agonists on pacemaker current in canine cardiac Purkinje fibers but has no direct action. A difference between primary and secondary pacemakers. Circulation Research. 66: 633-6. PMID 1968362 DOI: 10.1161/01.Res.66.3.633  0.355
1990 Oliva C, Cohen IS, Pennefather P. The mechanism of rectification of iK1 in canine Purkinje myocytes. The Journal of General Physiology. 96: 299-318. PMID 1698915 DOI: 10.1085/Jgp.96.2.299  0.411
1989 Cohen IS, DiFrancesco D, Mulrine NK, Pennefather P. Internal and external K+ help gate the inward rectifier. Biophysical Journal. 55: 197-202. PMID 2930821 DOI: 10.1016/S0006-3495(89)82792-4  0.366
1988 Shah A, Cohen IS, Rosen MR. Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway. Biophysical Journal. 54: 219-25. PMID 2850027 DOI: 10.1016/S0006-3495(88)82950-3  0.316
1987 Cohen IS, Kline RP, Pennefather P, Mulrine NK. Models of the Na-K pump in cardiac muscle predict the wrong intracellular Na+ activity. Proceedings of the Royal Society of London. Series B, Biological Sciences. 231: 371-82. PMID 2888124 DOI: 10.1098/Rspb.1987.0050  0.321
1987 Shah AK, Cohen IS, Datyner NB. Background K+ current in isolated canine cardiac Purkinje myocytes. Biophysical Journal. 52: 519-25. PMID 2445390 DOI: 10.1016/S0006-3495(87)83241-1  0.368
1987 Cohen IS, Datyner NB, Gintant GA, Mulrine NK, Pennefather P. Properties of an electrogenic sodium-potassium pump in isolated canine Purkinje myocytes. The Journal of Physiology. 383: 251-67. PMID 2443647 DOI: 10.1113/Jphysiol.1987.Sp016407  0.339
1985 Cohen I, Falk R, Gintant G. Saturation of the internal sodium site of the sodium pump can distort estimates of potassium affinity. Biophysical Journal. 46: 719-27. PMID 6097317 DOI: 10.1016/S0006-3495(84)84070-9  0.305
1985 Gintant GA, Datyner NB, Cohen IS. Gating of delayed rectification in acutely isolated canine cardiac Purkinje myocytes. Evidence for a single voltage-gated conductance. Biophysical Journal. 48: 1059-64. PMID 4092068 DOI: 10.1016/S0006-3495(85)83869-8  0.4
1985 Cohen IS, Datyner NB, Gintant GA, Mulrine NK, Pennefather P. A note on the relation of maximum upstroke velocity to peak inward current recorded by the voltage clamp. Circulation Research. 57: 482-4. PMID 4028350 DOI: 10.1161/01.Res.57.3.482  0.318
1984 Van der Kloot W, Cohen IS. End-plate potentials in a model muscle fiber. Corrections for the effects of membrane potential on currents and on channel lifetimes. Biophysical Journal. 45: 905-11. PMID 6329346 DOI: 10.1016/S0006-3495(84)84237-X  0.312
1984 Gintant GA, Datyner NB, Cohen IS. Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers. Biophysical Journal. 45: 509-12. PMID 6324914 DOI: 10.1016/S0006-3495(84)84187-9  0.414
1983 Cohen IS, Falk RT, Mulrine NK. Actions of barium and rubidium on membrane currents in canine Purkinje fibres. The Journal of Physiology. 338: 589-612. PMID 6875972 DOI: 10.1113/Jphysiol.1983.Sp014691  0.358
1983 Binah O, Cohen IS, Rosen MR. The effects of adriamycin on normal and ouabain-toxic canine Purkinje and ventricular muscle fibers. Circulation Research. 53: 655-62. PMID 6313254 DOI: 10.1161/01.Res.53.5.655  0.343
1983 Cohen IS, Van der Kloot W. Effects of low temperature and terminal membrane potential on quantal size at frog neuromuscular junction. The Journal of Physiology. 336: 335-44. PMID 6308226 DOI: 10.1113/Jphysiol.1983.Sp014584  0.32
1983 Cohen IS, Falk RT, Kline RP. Voltage-clamp studies on the canine Purkinje strand. Proceedings of the Royal Society of London. Series B, Biological Sciences. 217: 215-36. PMID 6132391 DOI: 10.1098/Rspb.1983.0007  0.365
1982 Cohen I, Van der Kloot W. The interaction of extracellular H+, Na+, Ca2+ and Sr2+ on the decay of miniature end-plate currents. Brain Research. 241: 285-90. PMID 6980690 DOI: 10.1016/0006-8993(82)91065-4  0.31
1981 Attwell D, Cohen I, Eisner DA. The effects of heart rate on the action potential of guinea-pig and human ventricular muscle. The Journal of Physiology. 313: 439-61. PMID 7277229 DOI: 10.1113/Jphysiol.1981.Sp013675  0.356
1981 Cohen I, Falk R, Kline R. Membrane currents following activity in canine cardiac Purkinje fibers Biophysical Journal. 33: 281-288. PMID 7225509 DOI: 10.1016/S0006-3495(81)84890-4  0.389
1981 Cohen I, van der Kloot W, Attwell D. The timing of channel opening during miniature end-plate currents. Brain Research. 223: 185-9. PMID 6974583 DOI: 10.1016/0006-8993(81)90821-0  0.362
1981 Cohen I, Attwell D, Strichartz G. The dependence of the maximum rate of rise of the action potential upstroke on membrane properties. Proceedings of the Royal Society of London. Series B, Biological Sciences. 214: 85-98. PMID 6121330 DOI: 10.1098/Rspb.1981.0083  0.33
1980 Kline RP, Cohen I, Falk R, Kupersmith J. Activity-dependent extracellular K+ fluctuations in canine Purkinje fibres. Nature. 286: 68-71. PMID 7393326 DOI: 10.1038/286068A0  0.346
1979 Attwell D, Cohen I, Eisner D, Ohba M, Ojeda C. The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. PflüGers Archiv : European Journal of Physiology. 379: 137-42. PMID 571107 DOI: 10.1007/Bf00586939  0.381
1979 Cohen I, Noble D, Ohba M, Ojeda C. The interaction of ouabain and salicylate on sheep cardiac muscle. The Journal of Physiology. 297: 187-205. PMID 536910 DOI: 10.1113/Jphysiol.1979.Sp013034  0.349
1979 Cohen I, Noble D, Ohba M, Ojeda C. Action of salicylate ions on the electrical properties of sheep cardiac Purkinje fibres. The Journal of Physiology. 297: 163-185. PMID 536909 DOI: 10.1113/Jphysiol.1979.Sp013033  0.365
1979 Attwell D, Cohen I, Eisner D. Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space. Proceedings of the Royal Society of London. Series B, Biological Sciences. 206: 145-61. PMID 42920 DOI: 10.1098/Rspb.1979.0098  0.304
1978 Cohen I, Eisner D, Noble D. The action of adrenaline on pace-maker activity in cardiac Purkinje fibres. The Journal of Physiology. 280: 155-68. PMID 690862 DOI: 10.1113/Jphysiol.1978.Sp012378  0.387
1978 Cohen I, Kloot WVD. Effects of [Ca2+] and [Mg2+] on the decay of miniature endplate currents. Nature. 271: 77-79. PMID 305002 DOI: 10.1038/271077A0  0.32
1977 Cohen IS, Strichartz GR. On the voltage-dependent action of tetrodotoxin. Biophysical Journal. 17: 275-9. PMID 843585 DOI: 10.1016/S0006-3495(77)85656-7  0.355
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