| Year |
Citation |
Score |
| 2023 |
Neidhardt L, Cloots E, Friemel N, Weiss CAM, Harding HP, McLaughlin SH, Janssens S, Ron D. The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells. The Embo Journal. PMID 38177498 DOI: 10.1038/s44318-023-00014-z |
0.327 |
|
| 2022 |
Perera LA, Ron D. AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis. Cold Spring Harbor Perspectives in Biology. PMID 36041787 DOI: 10.1101/cshperspect.a041265 |
0.309 |
|
| 2019 |
De Franco E, Caswell R, Johnson MB, Wakeling MN, Zung A, Dũng VC, Bích Ngọc CT, Goonetilleke R, Jury MV, El-Khateeb M, Ellard S, Flanagan SE, Ron D, Hattersley AT. Mutations in Affecting eIF2 Signaling Cause Neonatal/Early Onset Diabetes and Transient Hepatic Dysfunction. Diabetes. PMID 31882561 DOI: 10.2337/Db19-1029 |
0.34 |
|
| 2019 |
Amin-Wetzel N, Neidhardt L, Yan Y, Mayer MP, Ron D. Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. Elife. 8. PMID 31873072 DOI: 10.2210/Pdb6Shc/Pdb |
0.425 |
|
| 2019 |
Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. Elife. 8. PMID 31749445 DOI: 10.7554/Elife.50149 |
0.39 |
|
| 2019 |
Perera LA, Rato C, Yan Y, Neidhardt L, McLaughlin SH, Read RJ, Preissler S, Ron D. An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP. The Embo Journal. e102177. PMID 31531998 DOI: 10.15252/Embj.2019102177 |
0.381 |
|
| 2019 |
Yan Y, Rato C, Rohland L, Preissler S, Ron D. MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nature Communications. 10: 541. PMID 30710085 DOI: 10.1038/S41467-019-08450-4 |
0.397 |
|
| 2019 |
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, ... ... Ron D, et al. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metabolism. PMID 30639358 DOI: 10.1016/J.Cmet.2018.12.016 |
0.351 |
|
| 2019 |
Yan Y, Rato C, Rohlan L, Preissler S, Ron D. MANF/ARMET antagonizes nucleotide exchange by the endoplasmic reticulum (ER) chaperone BiP_ Nature Communications. DOI: 10.2210/Pdb6Ha7/Pdb |
0.323 |
|
| 2018 |
Preissler S, Ron D. Erratum: Early Events in the Endoplasmic Reticulum Unfolded Protein Response. Cold Spring Harbor Perspectives in Biology. 10. PMID 30510064 DOI: 10.1101/Cshperspect.A037309 |
0.362 |
|
| 2018 |
Preissler S, Ron D. Early Events in the Endoplasmic Reticulum Unfolded Protein Response. Cold Spring Harbor Perspectives in Biology. PMID 30396883 DOI: 10.1101/Cshperspect.A033894 |
0.463 |
|
| 2018 |
Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E. Single particle trajectories reveal active endoplasmic reticulum luminal flow. Nature Cell Biology. PMID 30224760 DOI: 10.1016/J.Bpj.2018.11.964 |
0.352 |
|
| 2018 |
Crespillo-Casado A, Claes Z, Choy MS, Peti W, Bollen M, Ron D. A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α. The Journal of Biological Chemistry. PMID 29618508 DOI: 10.1074/Jbc.Ra118.002325 |
0.365 |
|
| 2018 |
Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D. Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science (New York, N.Y.). 359: 1533-1536. PMID 29599245 DOI: 10.1126/Science.Aar5129 |
0.392 |
|
| 2017 |
Amin-Wetzel N, Saunders RA, Kamphuis MJ, Rato C, Preissler S, Harding HP, Ron D. A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell. 171: 1625-1637.e13. PMID 29198525 DOI: 10.1016/J.Cell.2017.10.040 |
0.47 |
|
| 2017 |
Preissler S, Rohland L, Yan Y, Chen R, Read RJ, Ron D. AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife. 6. PMID 29064368 DOI: 10.7554/Elife.29428 |
0.415 |
|
| 2017 |
Huang HW, Zeng X, Rhim T, Ron D, Ryoo HD. The requirement of IRE1-XBP1 in resolving physiological stress during Drosophila development. Journal of Cell Science. PMID 28775151 DOI: 10.1242/Jcs.203612 |
0.463 |
|
| 2017 |
Kono N, Amin-Wetzel N, Ron D. Generic membrane spanning features endow IRE1α with responsiveness to membrane aberrancy. Molecular Biology of the Cell. PMID 28615323 DOI: 10.1091/Mbc.E17-03-0144 |
0.389 |
|
| 2017 |
Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D. PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. Elife. 6. PMID 28447936 DOI: 10.7554/Elife.26109 |
0.419 |
|
| 2017 |
Melo EP, Lopes C, Gollwitzer P, Lortz S, Lenzen S, Mehmeti I, Kaminski CF, Ron D, Avezov E. TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2. Bmc Biology. 15: 24. PMID 28347335 DOI: 10.1186/S12915-017-0367-5 |
0.312 |
|
| 2017 |
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, ... ... Ron D, et al. Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. The Journal of Experimental Medicine. PMID 28082357 DOI: 10.1084/Jem.20160791 |
0.38 |
|
| 2017 |
Cheah K, Wang MC, Tan TZ, Tsang KY, Leung K, Itoh N, Ron D, Chan D. Mechanisms of chondrocyte adaptation and survival under ER stress Mechanisms of Development. 145. DOI: 10.1016/J.Mod.2017.04.589 |
0.329 |
|
| 2016 |
Preissler S, Rato C, Perera LA, Saudek V, Ron D. FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP. Nature Structural & Molecular Biology. PMID 27918543 DOI: 10.1038/Nsmb.3337 |
0.433 |
|
| 2016 |
Sekine Y, Zyryanova A, Crespillo-Casado A, Amin-Wetzel N, Harding HP, Ron D. Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells. Plos One. 11: e0166278. PMID 27812215 DOI: 10.1371/Journal.Pone.0166278 |
0.399 |
|
| 2016 |
Stone S, Ho Y, Li X, Jamison S, Harding HP, Ron D, Lin W. Dual role of the integrated stress response in medulloblastoma tumorigenesis. Oncotarget. 7: 64124-64135. PMID 27802424 DOI: 10.18632/Oncotarget.11873 |
0.39 |
|
| 2016 |
Ho Y, Li X, Jamison S, Harding HP, McKinnon PJ, Ron D, Lin W. PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis. The American Journal of Pathology. PMID 27181404 DOI: 10.1016/J.Ajpath.2016.03.004 |
0.339 |
|
| 2015 |
Preissler S, Rato C, Chen R, Antrobus R, Ding S, Fearnley IM, Ron D. AMPylation matches BiP activity to client protein load in the endoplasmic reticulum. Elife. 4. PMID 26673894 DOI: 10.7554/Elife.12621 |
0.47 |
|
| 2015 |
Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, ... ... Ron D, et al. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron. PMID 26526393 DOI: 10.1016/J.Neuron.2015.10.030 |
0.302 |
|
| 2015 |
Konno T, Pinho Melo E, Lopes C, Mehmeti I, Lenzen S, Ron D, Avezov E. ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding. The Journal of Cell Biology. 211: 253-9. PMID 26504166 DOI: 10.1083/Jcb.201506123 |
0.331 |
|
| 2015 |
Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S. Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26487695 DOI: 10.1096/Fj.15-275990 |
0.375 |
|
| 2015 |
Preissler S, Chambers JE, Crespillo-Casado A, Avezov E, Miranda E, Perez J, Hendershot LM, Harding HP, Ron D. Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker. Elife. 4. PMID 26473973 DOI: 10.7554/Elife.08961 |
0.41 |
|
| 2015 |
Abdulkarim B, Nicolino M, Igoillo-Esteve M, Daures M, Romero S, Philippi A, Senée V, Lopes M, Cunha DA, Harding HP, Derbois C, Bendelac N, Hattersley AT, Eizirik DL, Ron D, et al. A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes. 64: 3951-62. PMID 26159176 DOI: 10.2337/Db15-0477 |
0.317 |
|
| 2015 |
Sekine Y, Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D. Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science (New York, N.Y.). 348: 1027-30. PMID 25858979 DOI: 10.1126/Science.Aaa6986 |
0.385 |
|
| 2015 |
Chen R, Rato C, Yan Y, Crespillo-Casado A, Clarke HJ, Harding HP, Marciniak SJ, Read RJ, Ron D. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife. 4. PMID 25774600 DOI: 10.7554/Elife.04871 |
0.331 |
|
| 2015 |
Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife. 4. PMID 25774599 DOI: 10.7554/Elife.04872 |
0.355 |
|
| 2015 |
Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death & Disease. 6: e1672. PMID 25741597 DOI: 10.1038/Cddis.2015.49 |
0.428 |
|
| 2015 |
Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo EP, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D. Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum. Bmc Biology. 13: 2. PMID 25575667 DOI: 10.1186/S12915-014-0112-2 |
0.328 |
|
| 2015 |
Volmer R, Ron D. Lipid-dependent regulation of the unfolded protein response. Current Opinion in Cell Biology. 33: 67-73. PMID 25543896 DOI: 10.1016/J.Ceb.2014.12.002 |
0.477 |
|
| 2015 |
Preissler S, Rato C, Chen R, Antrobus R, Ding S, Fearnley IM, Ron D. Author response: AMPylation matches BiP activity to client protein load in the endoplasmic reticulum Elife. DOI: 10.7554/Elife.12621.031 |
0.35 |
|
| 2015 |
Parzych K, Loaiza S, Chinn TM, May P, Porsch F, Karadimitris A, Driessen C, Harding HP, Ron D, Auner HW. Abstract 1261: Comprehensive failure of intracellular protein homeostasis kills myeloma and solid cancer cells following VCP/p97 inhibition Cancer Research. 75: 1261-1261. DOI: 10.1158/1538-7445.Am2015-1261 |
0.431 |
|
| 2014 |
Lin Y, Pang X, Huang G, Jamison S, Fang J, Harding HP, Ron D, Lin W. Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12182-91. PMID 25186761 DOI: 10.1523/Jneurosci.1373-14.2014 |
0.318 |
|
| 2014 |
Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Pinho Melo E, Harding HP, Ron D. Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants. Elife. 3: e03421. PMID 25073928 DOI: 10.7554/Elife.03421 |
0.407 |
|
| 2014 |
Le Pape S, Dimitrova E, Hannaert P, Konovalov A, Volmer R, Ron D, Thuillier R, Hauet T. Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. Febs Letters. 588: 3062-7. PMID 24945730 DOI: 10.1016/J.Febslet.2014.05.065 |
0.356 |
|
| 2014 |
Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B'chir W, Muranishi Y, Ron D, Pénicaud L, et al. Hypothalamic eIF2α signaling regulates food intake. Cell Reports. 6: 438-44. PMID 24485657 DOI: 10.1016/J.Celrep.2014.01.006 |
0.346 |
|
| 2014 |
Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science (New York, N.Y.). 343: 313-7. PMID 24310610 DOI: 10.1126/Science.1246829 |
0.301 |
|
| 2014 |
Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Molecular and Cellular Biology. 34: 428-38. PMID 24248597 DOI: 10.1128/Mcb.00946-13 |
0.336 |
|
| 2014 |
Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ. Author response: Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation Elife. DOI: 10.7554/Elife.04872.021 |
0.34 |
|
| 2014 |
Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Melo EP, Harding HP, Ron D. Author response: Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants Elife. DOI: 10.7554/Elife.03421.013 |
0.396 |
|
| 2013 |
Coelho DS, Cairrão F, Zeng X, Pires E, Coelho AV, Ron D, Ryoo HD, Domingos PM. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Cell Reports. 5: 791-801. PMID 24183663 DOI: 10.1016/J.Celrep.2013.09.046 |
0.389 |
|
| 2013 |
Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K. Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. The Journal of Cell Biology. 202: 861-74. PMID 24043701 DOI: 10.1083/Jcb.201303027 |
0.311 |
|
| 2013 |
Tomasio SM, Harding HP, Ron D, Cross BC, Bond PJ. Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification. Molecular Biosystems. 9: 2408-16. PMID 23884086 DOI: 10.1039/C3Mb70234K |
0.414 |
|
| 2013 |
Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell Structure and Function. 38: 183-95. PMID 23812432 DOI: 10.1247/Csf.13012 |
0.376 |
|
| 2013 |
Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host & Microbe. 13: 558-69. PMID 23684307 DOI: 10.1016/J.Chom.2013.03.011 |
0.428 |
|
| 2013 |
Avezov E, Cross BC, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. The Journal of Cell Biology. 201: 337-49. PMID 23589496 DOI: 10.1083/Jcb.201211155 |
0.388 |
|
| 2013 |
Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5980-91. PMID 23554479 DOI: 10.1523/Jneurosci.1636-12.2013 |
0.327 |
|
| 2013 |
D'Antonio M, Musner N, Scapin C, Ungaro D, Del Carro U, Ron D, Feltri ML, Wrabetz L. Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. The Journal of Experimental Medicine. 210: 821-38. PMID 23547100 DOI: 10.1084/Jem.20122005 |
0.39 |
|
| 2013 |
Volmer R, van der Ploeg K, Ron D. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proceedings of the National Academy of Sciences of the United States of America. 110: 4628-33. PMID 23487760 DOI: 10.1073/Pnas.1217611110 |
0.412 |
|
| 2013 |
Tsuru A, Fujimoto N, Takahashi S, Saito M, Nakamura D, Iwano M, Iwawaki T, Kadokura H, Ron D, Kohno K. Negative feedback by IRE1β optimizes mucin production in goblet cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2864-9. PMID 23386727 DOI: 10.1073/Pnas.1212484110 |
0.418 |
|
| 2012 |
Ron D, Harding HP. Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209157 DOI: 10.1101/Cshperspect.A013177 |
0.477 |
|
| 2012 |
Harding HP, Zyryanova AF, Ron D. Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. The Journal of Biological Chemistry. 287: 44338-44. PMID 23148209 DOI: 10.1074/Jbc.M112.428987 |
0.412 |
|
| 2012 |
Cross BC, Ron D. New twists in the unfolded protein response. Elife. 1: e00243. PMID 23066509 DOI: 10.7554/Elife.00243 |
0.366 |
|
| 2012 |
Zito E, Hansen HG, Yeo GS, Fujii J, Ron D. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Molecular Cell. 48: 39-51. PMID 22981861 DOI: 10.1016/J.Molcel.2012.08.010 |
0.344 |
|
| 2012 |
Landau G, Ran A, Bercovich Z, Feldmesser E, Horn-Saban S, Korkotian E, Jacob-Hirsh J, Rechavi G, Ron D, Kahana C. Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. The Journal of Biological Chemistry. 287: 35825-37. PMID 22942278 DOI: 10.1074/Jbc.M112.381335 |
0.435 |
|
| 2012 |
Chambers JE, Petrova K, Tomba G, Vendruscolo M, Ron D. ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load. The Journal of Cell Biology. 198: 371-85. PMID 22869598 DOI: 10.1083/Jcb.20120200511112014C |
0.438 |
|
| 2012 |
Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes. 61: 2763-75. PMID 22773666 DOI: 10.2337/Db12-0123 |
0.438 |
|
| 2012 |
Pavitt GD, Ron D. New insights into translational regulation in the endoplasmic reticulum unfolded protein response. Cold Spring Harbor Perspectives in Biology. 4. PMID 22535228 DOI: 10.1101/Cshperspect.A012278 |
0.478 |
|
| 2012 |
Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proceedings of the National Academy of Sciences of the United States of America. 109: E869-78. PMID 22315414 DOI: 10.1073/Pnas.1115623109 |
0.377 |
|
| 2011 |
Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science (New York, N.Y.). 334: 1081-6. PMID 22116877 DOI: 10.1126/Science.1209038 |
0.474 |
|
| 2011 |
Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... Ron D, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893 |
0.358 |
|
| 2011 |
Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, ... Ron D, et al. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. The Journal of Biological Chemistry. 286: 36163-70. PMID 21832042 DOI: 10.1074/Jbc.M111.228817 |
0.347 |
|
| 2011 |
Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Molecular Biology of the Cell. 22: 2994-3009. PMID 21737679 DOI: 10.1091/Mbc.E11-04-0286 |
0.396 |
|
| 2011 |
Wang D, Zavadil J, Martin L, Parisi F, Friedman E, Levy D, Harding H, Ron D, Gardner LB. Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Molecular and Cellular Biology. 31: 3670-80. PMID 21730287 DOI: 10.1128/Mcb.05704-11 |
0.399 |
|
| 2011 |
Lin W, Lin Y, Li J, Harding HP, Ron D, Jamison S. A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma. Journal of Neuroscience Research. 89: 1586-95. PMID 21688289 DOI: 10.1002/Jnr.22693 |
0.413 |
|
| 2011 |
Cui W, Li J, Ron D, Sha B. The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallographica. Section D, Biological Crystallography. 67: 423-8. PMID 21543844 DOI: 10.1107/S0907444911006445 |
0.407 |
|
| 2011 |
Chin KT, Kang G, Qu J, Gardner LB, Coetzee WA, Zito E, Fishman GI, Ron D. The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2583-91. PMID 21507899 DOI: 10.1096/Fj.11-184622 |
0.313 |
|
| 2011 |
Tsaytler P, Harding HP, Ron D, Bertolotti A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science (New York, N.Y.). 332: 91-4. PMID 21385720 DOI: 10.1126/Science.1201396 |
0.451 |
|
| 2011 |
Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature Cell Biology. 13: 184-90. PMID 21364565 DOI: 10.1038/Ncb0311-184 |
0.37 |
|
| 2011 |
Ron D, Ito K. Cell biology. A translational pause to localize. Science (New York, N.Y.). 331: 543-4. PMID 21292960 DOI: 10.1126/Science.1202075 |
0.404 |
|
| 2011 |
Marion V, Sankaranarayanan S, de Theije C, van Dijk P, Lindsey P, Lamers MC, Harding HP, Ron D, Lamers WH, Köhler SE. Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. The Journal of Biological Chemistry. 286: 8866-74. PMID 21239484 DOI: 10.1074/Jbc.M110.216119 |
0.335 |
|
| 2010 |
Zito E, Melo EP, Yang Y, Wahlander Ã…, Neubert TA, Ron D. Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Molecular Cell. 40: 787-97. PMID 21145486 DOI: 10.1016/J.Molcel.2010.11.010 |
0.349 |
|
| 2010 |
Wang H, Blais J, Ron D, Cardozo T. Structural determinants of PERK inhibitor potency and selectivity. Chemical Biology & Drug Design. 76: 480-95. PMID 21070610 DOI: 10.1111/J.1747-0285.2010.01048.X |
0.342 |
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| 2010 |
Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. Journal of Cell Science. 123: 3849-55. PMID 21048161 DOI: 10.1242/Jcs.075119 |
0.346 |
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| 2010 |
Marcinak SJ, Ron D. The unfolded protein response in lung disease. Proceedings of the American Thoracic Society. 7: 356-62. PMID 21030513 DOI: 10.1513/pats.201001-015AW |
0.349 |
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| 2010 |
Volchuk A, Ron D. The endoplasmic reticulum stress response in the pancreatic β-cell. Diabetes, Obesity & Metabolism. 12: 48-57. PMID 21029300 DOI: 10.1111/j.1463-1326.2010.01271.x |
0.325 |
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| 2010 |
Appenzeller-Herzog C, Riemer J, Zito E, Chin KT, Ron D, Spiess M, Ellgaard L. Disulphide production by Ero1α-PDI relay is rapid and effectively regulated. The Embo Journal. 29: 3318-29. PMID 20802462 DOI: 10.1038/Emboj.2010.203 |
0.37 |
|
| 2010 |
Onn A, Ron D. Modeling the endoplasmic reticulum unfolded protein response. Nature Structural & Molecular Biology. 17: 924-5. PMID 20683476 DOI: 10.1038/Nsmb0810-924 |
0.377 |
|
| 2010 |
Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. The Embo Journal. 29: 2082-96. PMID 20473272 DOI: 10.1038/Emboj.2010.81 |
0.39 |
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| 2010 |
Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. The Journal of Biological Chemistry. 285: 20993-1003. PMID 20442408 DOI: 10.1074/Jbc.M110.126599 |
0.367 |
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| 2010 |
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/J.Molcel.2010.04.001 |
0.401 |
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| 2010 |
Zito E, Chin KT, Blais J, Harding HP, Ron D. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. The Journal of Cell Biology. 188: 821-32. PMID 20308425 DOI: 10.1083/Jcb.200911086 |
0.32 |
|
| 2010 |
Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. Plos One. 5: e9575. PMID 20221394 DOI: 10.1371/Journal.Pone.0009575 |
0.42 |
|
| 2010 |
Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Molecular Cell. 37: 529-40. PMID 20188671 DOI: 10.1016/J.Molcel.2010.01.015 |
0.366 |
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| 2010 |
Tao J, Petrova K, Ron D, Sha B. Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR. Journal of Molecular Biology. 397: 1307-15. PMID 20184891 DOI: 10.1016/J.Jmb.2010.02.028 |
0.334 |
|
| 2010 |
Wiseman RL, Haynes CM, Ron D. SnapShot: The unfolded protein response. Cell. 140: 590-590.e2. PMID 20178750 DOI: 10.1016/J.Cell.2010.02.006 |
0.371 |
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| 2010 |
Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot LM, Sitia R. CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Molecular Immunology. 47: 1356-65. PMID 20044139 DOI: 10.1016/J.Molimm.2009.12.003 |
0.436 |
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| 2010 |
Zhao L, Rosales C, Seburn K, Ron D, Ackerman SL. Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome. Human Molecular Genetics. 19: 25-35. PMID 19801575 DOI: 10.1093/Hmg/Ddp464 |
0.441 |
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| 2009 |
Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nature Cell Biology. 11: 1473-80. PMID 19855386 DOI: 10.1038/Ncb1996 |
0.416 |
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| 2009 |
Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. The Journal of Cell Biology. 186: 783-92. PMID 19752026 DOI: 10.1083/Jcb.200904060 |
0.381 |
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| 2009 |
Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 12055-60. PMID 19567830 DOI: 10.1073/Pnas.0903919106 |
0.312 |
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| 2009 |
Thorp E, Li G, Seimon TA, Kuriakose G, Ron D, Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metabolism. 9: 474-81. PMID 19416717 DOI: 10.1016/J.Cmet.2009.03.003 |
0.316 |
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| 2009 |
Ron D. Targeting of mRNAs to their sites of unconventional splicing in the unfolded protein response. Molecular Cell. 34: 133-4. PMID 19394288 DOI: 10.1016/J.Molcel.2009.04.003 |
0.32 |
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| 2009 |
Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. The Journal of Biological Chemistry. 284: 15233-45. PMID 19349280 DOI: 10.1074/Jbc.M109.002121 |
0.399 |
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| 2009 |
Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proceedings of the National Academy of Sciences of the United States of America. 106: 1832-7. PMID 19181853 DOI: 10.1073/Pnas.0809632106 |
0.441 |
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| 2009 |
Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2200-5. PMID 19164757 DOI: 10.1073/Pnas.0807611106 |
0.455 |
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| 2009 |
Lin JH, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. Plos One. 4: e4170. PMID 19137072 DOI: 10.1371/Journal.Pone.0004170 |
0.402 |
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| 2008 |
Petrova K, Oyadomari S, Hendershot LM, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. The Embo Journal. 27: 2862-72. PMID 18923430 DOI: 10.1038/Emboj.2008.199 |
0.359 |
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| 2008 |
Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. The American Journal of Pathology. 173: 1508-17. PMID 18818381 DOI: 10.2353/Ajpath.2008.080449 |
0.398 |
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| 2008 |
Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. The Journal of Clinical Investigation. 118: 3378-89. PMID 18776938 DOI: 10.1172/Jci34587 |
0.383 |
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| 2008 |
Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA. Novel function of PERK as a mediator of force-induced apoptosis. The Journal of Biological Chemistry. 283: 23462-72. PMID 18550523 DOI: 10.1074/Jbc.M803194200 |
0.315 |
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| 2008 |
Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metabolism. 7: 520-32. PMID 18522833 DOI: 10.1016/J.Cmet.2008.04.011 |
0.406 |
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| 2008 |
Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 105: 7094-9. PMID 18467495 DOI: 10.1073/Pnas.0707025105 |
0.413 |
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| 2008 |
Iqbal J, Dai K, Seimon T, Jungreis R, Oyadomari M, Kuriakose G, Ron D, Tabas I, Hussain MM. IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metabolism. 7: 445-55. PMID 18460335 DOI: 10.1016/J.Cmet.2008.03.005 |
0.365 |
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| 2008 |
Tao J, Wu Y, Ron D, Sha B. Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 108-10. PMID 18259061 DOI: 10.1107/S1744309108000833 |
0.406 |
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| 2008 |
Pennuto M, Tinelli E, Malaguti M, Del Carro U, D'Antonio M, Ron D, Quattrini A, Feltri ML, Wrabetz L. Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron. 57: 393-405. PMID 18255032 DOI: 10.1016/J.Neuron.2007.12.021 |
0.423 |
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| 2008 |
Ron D, Hubbard SR. How IRE1 reacts to ER stress. Cell. 132: 24-6. PMID 18191217 DOI: 10.1016/J.Cell.2007.12.017 |
0.388 |
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| 2008 |
Harding HP, Lackey JG, Hsu HC, Zhang Y, Deng J, Xu RM, Damha MJ, Ron D. An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. Rna (New York, N.Y.). 14: 225-32. PMID 18094117 DOI: 10.1261/Rna.859908 |
0.424 |
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| 2008 |
Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE. Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. The Journal of Biological Chemistry. 283: 469-75. PMID 17998206 DOI: 10.1074/Jbc.M704612200 |
0.377 |
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| 2007 |
Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell. 13: 467-80. PMID 17925224 DOI: 10.1016/J.Devcel.2007.07.016 |
0.401 |
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| 2007 |
Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. The American Journal of Pathology. 171: 513-24. PMID 17620365 DOI: 10.2353/Ajpath.2007.070188 |
0.458 |
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| 2007 |
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews. Molecular Cell Biology. 8: 519-29. PMID 17565364 DOI: 10.1038/Nrm2199 |
0.467 |
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| 2007 |
Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. The Journal of Cell Biology. 176: 605-16. PMID 17325203 DOI: 10.1083/Jcb.200607007 |
0.375 |
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| 2007 |
Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. The Journal of Clinical Investigation. 117: 448-56. PMID 17273557 DOI: 10.1172/Jci29571 |
0.354 |
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| 2007 |
Ron D, Harding HP. 13 eIF2α Phosphorylation in Cellular Stress Responses and Disease Cold Spring Harbor Monograph Archive. 48: 345-368. DOI: 10.1101/087969767.48.345 |
0.445 |
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| 2006 |
Blais JD, Addison CL, Edge R, Falls T, Zhao H, Wary K, Koumenis C, Harding HP, Ron D, Holcik M, Bell JC. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Molecular and Cellular Biology. 26: 9517-32. PMID 17030613 DOI: 10.1128/Mcb.01145-06 |
0.359 |
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| 2006 |
Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiological Reviews. 86: 1133-49. PMID 17015486 DOI: 10.1152/Physrev.00015.2006 |
0.373 |
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| 2006 |
Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Molecular Cell. 23: 875-85. PMID 16973439 DOI: 10.1016/J.Molcel.2006.07.023 |
0.436 |
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| 2006 |
Clase AC, Dimcheff DE, Favara C, Dorward D, McAtee FJ, Parrie LE, Ron D, Portis JL. Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses. The American Journal of Pathology. 169: 1026-38. PMID 16936275 DOI: 10.2353/Ajpath.2006.051357 |
0.409 |
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| 2006 |
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126: 727-39. PMID 16923392 DOI: 10.1016/J.Cell.2006.06.051 |
0.466 |
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| 2006 |
Ron D. Cell biology. Stressed cells cope with protein overload. Science (New York, N.Y.). 313: 52-3. PMID 16825557 DOI: 10.1126/Science.1130469 |
0.435 |
|
| 2006 |
Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics. 174: 229-39. PMID 16816413 DOI: 10.1534/Genetics.106.061580 |
0.381 |
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| 2006 |
Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, Sonenberg N, Carrasco L, de Haro C. Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. The Embo Journal. 25: 1730-40. PMID 16601681 DOI: 10.1038/Sj.Emboj.7601073 |
0.354 |
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| 2006 |
Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B. Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain : a Journal of Neurology. 129: 1306-18. PMID 16504972 DOI: 10.1093/Brain/Awl044 |
0.329 |
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| 2006 |
Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. The Journal of Cell Biology. 172: 201-9. PMID 16418533 DOI: 10.1083/Jcb.200508099 |
0.401 |
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| 2006 |
Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S. ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. Journal of Cell Science. 119: 153-61. PMID 16352659 DOI: 10.1242/Jcs.02731 |
0.379 |
|
| 2006 |
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding H, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload (DOI:10.1016/j.cell.2006.06.051) Cell. 127: 1284. DOI: 10.1016/j.cell.2006.11.027 |
0.307 |
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| 2005 |
Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metabolism. 2: 361-71. PMID 16330322 DOI: 10.1016/J.Cmet.2005.11.005 |
0.455 |
|
| 2005 |
Skalet AH, Isler JA, King LB, Harding HP, Ron D, Monroe JG. Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. The Journal of Biological Chemistry. 280: 39762-71. PMID 16188879 DOI: 10.1074/Jbc.M502640200 |
0.366 |
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| 2005 |
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. The Embo Journal. 24: 3470-81. PMID 16148948 DOI: 10.1038/Sj.Emboj.7600777 |
0.378 |
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| 2005 |
Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of Neurochemistry. 95: 974-86. PMID 16135078 DOI: 10.1111/J.1471-4159.2005.03428.X |
0.308 |
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| 2005 |
Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, ... Ron D, et al. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 436: 1166-73. PMID 16121183 DOI: 10.1038/Nature03897 |
0.311 |
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| 2005 |
Kantor L, Harding HP, Ron D, Schiffmann R, Kaneski CR, Kimball SR, Elroy-Stein O. Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients. Human Genetics. 118: 99-106. PMID 16041584 DOI: 10.1007/S00439-005-0024-X |
0.443 |
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| 2005 |
Federovitch CM, Ron D, Hampton RY. The dynamic ER: experimental approaches and current questions. Current Opinion in Cell Biology. 17: 409-14. PMID 15975777 DOI: 10.1016/J.Ceb.2005.06.010 |
0.331 |
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| 2005 |
Lin W, Harding HP, Ron D, Popko B. Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. The Journal of Cell Biology. 169: 603-12. PMID 15911877 DOI: 10.1083/Jcb.200502086 |
0.407 |
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| 2005 |
Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, Mellor AL. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity. 22: 633-42. PMID 15894280 DOI: 10.1016/J.Immuni.2005.03.013 |
0.34 |
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| 2005 |
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/Science.1101902 |
0.394 |
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| 2004 |
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes & Development. 18: 3066-77. PMID 15601821 DOI: 10.1101/Gad.1250704 |
0.464 |
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| 2004 |
Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/Mcb.24.23.10161-10168.2004 |
0.419 |
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| 2004 |
Lu PD, Harding HP, Ron D. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. The Journal of Cell Biology. 167: 27-33. PMID 15479734 DOI: 10.1083/Jcb.200408003 |
0.434 |
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| 2004 |
Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. The Journal of Cell Biology. 167: 23-5. PMID 15479733 DOI: 10.1083/Jcb.200408117 |
0.377 |
|
| 2004 |
Ron D, Oyadomari S. Lipid phase perturbations and the unfolded protein response. Developmental Cell. 7: 287-8. PMID 15363403 DOI: 10.1016/J.Devcel.2004.08.011 |
0.334 |
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| 2004 |
Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC. Activating transcription factor 4 is translationally regulated by hypoxic stress. Molecular and Cellular Biology. 24: 7469-82. PMID 15314157 DOI: 10.1128/Mcb.24.17.7469-7482.2004 |
0.496 |
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| 2004 |
Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Journal of Cell Science. 117: 4055-66. PMID 15280428 DOI: 10.1242/Jcs.01275 |
0.355 |
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| 2004 |
Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 429: 841-7. PMID 15215856 DOI: 10.1038/Nature02656 |
0.402 |
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| 2004 |
Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Molecular and Cellular Biology. 24: 5721-32. PMID 15199129 DOI: 10.1128/Mcb.24.13.5721-5732.2004 |
0.388 |
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| 2004 |
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Molecular and Cellular Biology. 24: 1365-77. PMID 14729979 DOI: 10.1128/Mcb.24.3.1365-1377.2004 |
0.469 |
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| 2004 |
Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. The Embo Journal. 23: 169-79. PMID 14713949 DOI: 10.1038/Sj.Emboj.7600030 |
0.436 |
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| 2004 |
Klint P, Hellman U, Wernstedt C, Aman P, Ron D, Claesson-Welsh L. Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1. Cellular Signalling. 16: 515-20. PMID 14709340 DOI: 10.1016/J.Cellsig.2003.09.007 |
0.352 |
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| 2003 |
Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP, Ron D. Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. The Journal of Cell Biology. 163: 767-75. PMID 14638860 DOI: 10.1083/Jcb.200308075 |
0.468 |
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| 2003 |
Feng B, Yao PM, Li Y, Devlin CM, Zhang D, Harding HP, Sweeney M, Rong JX, Kuriakose G, Fisher EA, Marks AR, Ron D, Tabas I. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell Biology. 5: 781-92. PMID 12907943 DOI: 10.1038/Ncb1035 |
0.316 |
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| 2003 |
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell. 11: 619-33. PMID 12667446 DOI: 10.1016/S1097-2765(03)00105-9 |
0.427 |
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| 2003 |
Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D. Stress-induced gene expression requires programmed recovery from translational repression. The Embo Journal. 22: 1180-7. PMID 12606582 DOI: 10.1093/Emboj/Cdg112 |
0.454 |
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| 2003 |
Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. American Journal of Physiology. Cell Physiology. 284: C273-84. PMID 12388085 DOI: 10.1152/Ajpcell.00314.2002 |
0.41 |
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| 2002 |
Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10690-8. PMID 12486162 DOI: 10.1523/Jneurosci.22-24-10690.2002 |
0.419 |
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| 2002 |
Harding HP, Ron D. Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes. 51: S455-61. PMID 12475790 DOI: 10.2337/Diabetes.51.2007.S455 |
0.415 |
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| 2002 |
Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG. Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proceedings of the National Academy of Sciences of the United States of America. 99: 15920-5. PMID 12446838 DOI: 10.1073/Pnas.252341799 |
0.481 |
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| 2002 |
Marcu MG, Doyle M, Bertolotti A, Ron D, Hendershot L, Neckers L. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Molecular and Cellular Biology. 22: 8506-13. PMID 12446770 DOI: 10.1128/Mcb.22.24.8506-8513.2002 |
0.432 |
|
| 2002 |
Ron D. Translational control in the endoplasmic reticulum stress response. The Journal of Clinical Investigation. 110: 1383-8. PMID 12438433 DOI: 10.1172/Jci16784 |
0.436 |
|
| 2002 |
Urano F, Calfon M, Yoneda T, Yun C, Kiraly M, Clark SG, Ron D. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. The Journal of Cell Biology. 158: 639-46. PMID 12186849 DOI: 10.1083/Jcb.200203086 |
0.486 |
|
| 2002 |
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Current Biology : Cb. 12: 1279-86. PMID 12176355 DOI: 10.1016/S0960-9822(02)01037-0 |
0.401 |
|
| 2002 |
Harding HP, Calfon M, Urano F, Novoa I, Ron D. Transcriptional and translational control in the Mammalian unfolded protein response. Annual Review of Cell and Developmental Biology. 18: 575-99. PMID 12142265 DOI: 10.1146/Annurev.Cellbio.18.011402.160624 |
0.442 |
|
| 2002 |
Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S. Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. The Journal of Cell Biology. 157: 1151-60. PMID 12082077 DOI: 10.1083/Jcb.200108103 |
0.399 |
|
| 2002 |
Yoneda T, Urano F, Ron D. Transmission of proteotoxicity across cellular compartments. Genes & Development. 16: 1307-13. PMID 12050110 DOI: 10.1101/Gad.1000902 |
0.35 |
|
| 2002 |
Ron D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. The Journal of Clinical Investigation. 109: 443-5. PMID 11854314 DOI: 10.1172/Jci15020 |
0.361 |
|
| 2002 |
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 415: 92-6. PMID 11780124 DOI: 10.1038/415092A |
0.436 |
|
| 2001 |
Harding HP, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F, Jousse C, Ron D. Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. Cold Spring Harbor Symposia On Quantitative Biology. 66: 499-508. PMID 12762052 DOI: 10.1101/Sqb.2001.66.499 |
0.325 |
|
| 2001 |
Jousse C, Bruhat A, Carraro V, Urano F, Ferrara M, Ron D, Fafournoux P. Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Research. 29: 4341-51. PMID 11691921 DOI: 10.1093/Nar/29.21.4341 |
0.434 |
|
| 2001 |
Sok J, Calfon M, Lu J, Lichtlen P, Clark SG, Ron D. Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity. Cell Stress & Chaperones. 6: 6-15. PMID 11525245 DOI: 10.1379/1466-1268(2001)006<0006:Airapa>2.0.Co;2 |
0.403 |
|
| 2001 |
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Molecular Cell. 7: 1153-63. PMID 11430819 DOI: 10.1016/S1097-2765(01)00264-7 |
0.453 |
|
| 2001 |
Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. Journal of Neurochemistry. 77: 1418-21. PMID 11389192 DOI: 10.1046/J.1471-4159.2001.00387.X |
0.318 |
|
| 2001 |
Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. The Journal of Cell Biology. 153: 1011-22. PMID 11381086 DOI: 10.1083/Jcb.153.5.1011 |
0.487 |
|
| 2001 |
Ron D. Hyperhomocysteinemia and function of the endoplasmic reticulum. The Journal of Clinical Investigation. 107: 1221-2. PMID 11375410 DOI: 10.1172/Jci13092 |
0.501 |
|
| 2001 |
Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH, West AB, Ron D. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. The Journal of Clinical Investigation. 107: 585-93. PMID 11238559 DOI: 10.1172/Jci11476 |
0.397 |
|
| 2000 |
Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nature Cell Biology. 2: 863-70. PMID 11146649 DOI: 10.1038/35046500 |
0.444 |
|
| 2000 |
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Molecular Cell. 6: 1099-108. PMID 11106749 DOI: 10.1016/S1097-2765(00)00108-8 |
0.475 |
|
| 2000 |
Urano F, Bertolotti A, Ron D. IRE1 and efferent signaling from the endoplasmic reticulum. Journal of Cell Science. 113: 3697-702. PMID 11034898 |
0.396 |
|
| 2000 |
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Molecular Cell. 5: 897-904. PMID 10882126 DOI: 10.1016/S1097-2765(00)80330-5 |
0.483 |
|
| 2000 |
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nature Cell Biology. 2: 326-32. PMID 10854322 DOI: 10.1038/35014014 |
0.465 |
|
| 2000 |
Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, Ron D. Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. The Embo Journal. 19: 453-62. PMID 10654943 DOI: 10.1093/Emboj/19.3.453 |
0.326 |
|
| 2000 |
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (New York, N.Y.). 287: 664-6. PMID 10650002 DOI: 10.1126/Science.287.5453.664 |
0.453 |
|
| 2000 |
Ron D, Harding HP. 15 PERK and Translational Control by Stress in the Endoplasmic Reticulum Cold Spring Harbor Monograph Archive. 39: 547-560. DOI: 10.1101/087969618.39.547 |
0.449 |
|
| 1999 |
Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, Habener JF. Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Developmental Biology. 216: 164-81. PMID 10588870 DOI: 10.1006/Dbio.1999.9460 |
0.52 |
|
| 1999 |
Wang XZ, Jolicoeur EM, Conte N, Chaffanet M, Zhang Y, Mozziconacci MJ, Feiner H, Birnbaum D, Pébusque MJ, Ron D. gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line. Oncogene. 18: 5718-21. PMID 10523851 DOI: 10.1038/Sj.Onc.1202950 |
0.317 |
|
| 1999 |
Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti JW, Jacobs KA, Fitz LJ, Murtha-Riel P, Turner KJ, Ron D. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proceedings of the National Academy of Sciences of the United States of America. 96: 5025-30. PMID 10220412 DOI: 10.1073/Pnas.96.9.5025 |
0.441 |
|
| 1999 |
Jousse C, Bruhat A, Harding HP, Ferrara M, Ron D, Fafournoux P. Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response. Febs Letters. 448: 211-6. PMID 10218478 DOI: 10.1016/S0014-5793(99)00373-7 |
0.397 |
|
| 1999 |
Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 397: 271-4. PMID 9930704 DOI: 10.1038/16729 |
0.468 |
|
| 1999 |
Sok J, Wang XZ, Batchvarova N, Kuroda M, Harding H, Ron D. CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Molecular and Cellular Biology. 19: 495-504. PMID 9858573 DOI: 10.1128/Mcb.19.1.495 |
0.41 |
|
| 1998 |
Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. The Embo Journal. 17: 5708-17. PMID 9755171 DOI: 10.1093/Emboj/17.19.5708 |
0.468 |
|
| 1998 |
Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, Zinszner H, Ron D. Identification of novel stress-induced genes downstream of chop. The Embo Journal. 17: 3619-30. PMID 9649432 DOI: 10.1093/Emboj/17.13.3619 |
0.486 |
|
| 1998 |
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes & Development. 12: 982-95. PMID 9531536 DOI: 10.1101/Gad.12.7.982 |
0.404 |
|
| 1998 |
Powers CA, Mathur M, Raaka BM, Ron D, Samuels HH. TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors. Molecular Endocrinology (Baltimore, Md.). 12: 4-18. PMID 9440806 DOI: 10.1210/Mend.12.1.0043 |
0.331 |
|
| 1997 |
Bruhat A, Jousse C, Wang XZ, Ron D, Ferrara M, Fafournoux P. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. The Journal of Biological Chemistry. 272: 17588-93. PMID 9211906 DOI: 10.1074/Jbc.272.28.17588 |
0.434 |
|
| 1997 |
Zinszner H, Immanuel D, Yin Y, Liang F, Ron D. A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited. Oncogene. 14: 451-461. PMID 9053842 DOI: 10.1038/Sj.Onc.1200854 |
0.372 |
|
| 1996 |
Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, Ron D. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Molecular and Cellular Biology. 16: 4273-80. PMID 8754828 DOI: 10.1128/Mcb.16.8.4273 |
0.431 |
|
| 1996 |
Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Molecular and Cellular Biology. 16: 1479-89. PMID 8657121 DOI: 10.1128/Mcb.16.4.1479 |
0.607 |
|
| 1996 |
Wang XZ, Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science (New York, N.Y.). 272: 1347-9. PMID 8650547 DOI: 10.1126/Science.272.5266.1347 |
0.392 |
|
| 1995 |
Immanuel D, Zinszner H, Ron D. Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. Molecular and Cellular Biology. 15: 4562-4571. PMID 7623847 DOI: 10.1128/Mcb.15.8.4562 |
0.345 |
|
| 1995 |
Batchvarova N, Wang XZ, Ron D. Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). The Embo Journal. 14: 4654-4661. DOI: 10.1002/J.1460-2075.1995.Tb00147.X |
0.401 |
|
| 1994 |
Zhan Q, Lord KA, Alamo I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace AJ. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Molecular and Cellular Biology. 14: 2361-71. PMID 8139541 DOI: 10.1128/Mcb.14.4.2361 |
0.356 |
|
| 1994 |
Barone MV, Crozat A, Tabaee A, Philipson L, Ron D. CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes & Development. 8: 453-64. PMID 8125258 DOI: 10.1101/Gad.8.4.453 |
0.435 |
|
| 1994 |
Zinszner H, Albalat R, Ron D. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Genes & Development. 8: 2513-26. PMID 7958914 DOI: 10.1101/Gad.8.21.2513 |
0.657 |
|
| 1994 |
Panagopoulos I, Åman P, Ron D, Höglund M, Mandahl N, Mitelman F. Two variants of the TLS-CHOP fusion transcript in myxoid liposarcomas with the 12;16 translocation Cancer Genetics and Cytogenetics. 77: 177. DOI: 10.1016/0165-4608(94)90343-3 |
0.309 |
|
| 1993 |
Crozat A, Åman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 363: 640-644. PMID 8510758 DOI: 10.1038/363640A0 |
0.379 |
|
| 1993 |
Vallejo M, Ron D, Miller CP, Habener JF. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proceedings of the National Academy of Sciences of the United States of America. 90: 4679-83. PMID 8506317 DOI: 10.1073/Pnas.90.10.4679 |
0.549 |
|
| 1993 |
McGehee RE, Ron D, Brasier AR, Habener JF. Differentiation-specific element: a cis-acting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Molecular Endocrinology (Baltimore, Md.). 7: 551-60. PMID 7684818 DOI: 10.1210/Mend.7.4.7684818 |
0.541 |
|
| 1993 |
Brasier AR, Ron D. Luciferase reporter gene assay in mammalian cells. Methods in Enzymology. 216: 386-97. PMID 1336098 DOI: 10.1016/0076-6879(92)16036-J |
0.368 |
|
| 1992 |
Ron D, Brasier AR, McGehee RE, Habener JF. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). The Journal of Clinical Investigation. 89: 223-33. PMID 1729273 DOI: 10.1172/Jci115566 |
0.586 |
|
| 1992 |
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes & Development. 6: 439-53. PMID 1547942 DOI: 10.1101/Gad.6.3.439 |
0.595 |
|
| 1991 |
Ron D, Brasier AR, Habener JF. Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Molecular and Cellular Biology. 11: 2887-95. PMID 2017183 DOI: 10.1128/Mcb.11.5.2887 |
0.586 |
|
| 1991 |
Brasier AR, Ron D. Use of Firefly Luciferase Reporter Gene to Study Angiotensinogen Acute Phase Response Element Methods in Neurosciences. 5: 108-123. DOI: 10.1016/B978-0-12-185259-7.50012-0 |
0.344 |
|
| 1990 |
Ron D, Brasier AR, Wright KA, Habener JF. The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Molecular and Cellular Biology. 10: 4389-95. PMID 2370871 DOI: 10.1128/mcb.10.8.4389-4395.1990 |
0.549 |
|
| 1990 |
Brasier AR, Ron D, Tate JE, Habener JF. A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. The Embo Journal. 9: 3933-44. PMID 2174352 DOI: 10.1002/J.1460-2075.1990.Tb07614.X |
0.574 |
|
| 1990 |
Ron D, Brasier AR, Habener JF. Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response. Molecular and Cellular Endocrinology. 74: C97-104. PMID 2128877 DOI: 10.1016/0303-7207(90)90221-S |
0.569 |
|
| 1990 |
Ron D, Brasier AR, Wright KA, Tate JE, Habener JF. An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Molecular and Cellular Biology. 10: 1023-32. PMID 2106065 DOI: 10.1128/Mcb.10.3.1023 |
0.573 |
|
| 1990 |
Brasier AR, Ron D, Tate JE, Habener JF. Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription. Molecular Endocrinology (Baltimore, Md.). 4: 1921-33. PMID 1707127 DOI: 10.1210/Mend-4-12-1921 |
0.588 |
|
| 1989 |
Brasier AR, Tate JE, Ron D, Habener JF. Multiple cis-acting DNA regulatory elements mediate hepatic angiotensinogen gene expression. Molecular Endocrinology (Baltimore, Md.). 3: 1022-34. PMID 2544800 DOI: 10.1210/Mend-3-6-1022 |
0.54 |
|
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