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Jeffery William Walker, Ph.D. - Publications

1988-2008 Physiology University of Wisconsin, Madison, Madison, WI 
 2008-2010 Physiology University of Arizona, Tucson, AZ 
control of cardiac myocyte function

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 McKee LA, Chen H, Regan JA, Behunin SM, Walker JW, Walker JS, Konhilas JP. Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice. Archives of Biochemistry and Biophysics. 535: 39-48. PMID 23352598 DOI: 10.1016/  1
2012 Kang M, Walker JW, Chung KY. Endothelin receptor overexpression alters diastolic function in cultured rat ventricular myocytes. Biomolecules & Therapeutics. 20: 386-92. PMID 24009825 DOI: 10.4062/biomolther.2012.20.4.386  1
2012 Oliveira SM, Zhang YH, Solis RS, Isackson H, Bellahcene M, Yavari A, Pinter K, Davies JK, Ge Y, Ashrafian H, Walker JW, Carling D, Watkins H, Casadei B, Redwood C. AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circulation Research. 110: 1192-201. PMID 22456184 DOI: 10.1161/CIRCRESAHA.111.259952  1
2012 Wang Y, Pinto JR, Solis RS, Dweck D, Liang J, Diaz-Perez Z, Ge Y, Walker JW, Potter JD. Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy. The Journal of Biological Chemistry. 287: 2156-67. PMID 22086914 DOI: 10.1074/jbc.M111.294306  1
2011 Upton DC, Welham NV, Kuo JS, Walker JW, Pasic TR. Chronic rhinosinusitis with nasal polyps: a proteomic analysis. The Annals of Otology, Rhinology, and Laryngology. 120: 780-6. PMID 22279949  1
2011 Sancho Solis R, Ge Y, Walker JW. A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I. Protein Science : a Publication of the Protein Society. 20: 894-907. PMID 21416543 DOI: 10.1002/pro.623  1
2010 Chen PP, Patel JR, Rybakova IN, Walker JW, Moss RL. Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C. The Journal of General Physiology. 136: 615-27. PMID 21115695 DOI: 10.1085/jgp.201010448  1
2010 Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M. Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. The Journal of Biological Chemistry. 285: 5674-82. PMID 20018870 DOI: 10.1074/jbc.M109.066456  1
2009 Ayaz-Guner S, Zhang J, Li L, Walker JW, Ge Y. In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated. Biochemistry. 48: 8161-70. PMID 19637843 DOI: 10.1021/bi900739f  1
2008 Sancho Solis R, Ge Y, Walker JW. Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry. Journal of Muscle Research and Cell Motility. 29: 203-12. PMID 19165611 DOI: 10.1007/s10974-009-9168-y  1
2008 Evans NJ, Walker JW. Sustained Ca2+ signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ finger. Canadian Journal of Physiology and Pharmacology. 86: 526-35. PMID 18758500 DOI: 10.1139/Y08-050  1
2008 Druckenbrod NR, Powers PA, Bartley CR, Walker JW, Epstein ML. Targeting of endothelin receptor-B to the neural crest. Genesis (New York, N.Y. : 2000). 46: 396-400. PMID 18693272 DOI: 10.1002/dvg.20415  1
2008 Walker JW. Protein scaffolds, lipid domains and substrate recognition in protein kinase c function: Implications for rational drug design Handbook of Experimental Pharmacology. 186: 185-203. PMID 18491053 DOI: 10.1007/978-3-540-72843-6-8  1
2008 Zabrouskov V, Ge Y, Schwartz J, Walker JW. Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry. Molecular & Cellular Proteomics : McP. 7: 1838-49. PMID 18445579 DOI: 10.1074/mcp.M700524-MCP200  1
2008 Evans NJ, Walker JW. Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophysical Journal. 95: 483-92. PMID 18424490 DOI: 10.1529/biophysj.107.119206  1
2008 Chung KY, Kang M, Walker JW. Contractile regulation by overexpressed ETA requires intact T tubules in adult rat ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2391-9. PMID 18326801 DOI: 10.1152/ajpheart.00011.2008  1
2007 Stelzer JE, Patel JR, Walker JW, Moss RL. Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation. Circulation Research. 101: 503-11. PMID 17641226 DOI: 10.1161/CIRCRESAHA.107.153650  1
2007 Kang M, Chung KY, Walker JW. G-protein coupled receptor signaling in myocardium: not for the faint of heart. Physiology (Bethesda, Md.). 22: 174-84. PMID 17557938 DOI: 10.1152/physiol.00051.2006  1
2007 Sarkisov DV, Gelber SE, Walker JW, Wang SS. Synapse specificity of calcium release probed by chemical two-photon uncaging of inositol 1,4,5-trisphosphate. The Journal of Biological Chemistry. 282: 25517-26. PMID 17540776 DOI: 10.1074/jbc.M609672200  1
2007 Liu J, Du J, Zhang C, Walker JW, Huang X. Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1273-81. PMID 17526646 DOI: 10.1152/ajpheart.01379.2006  1
2007 Chung KY, Walker JW. Interaction and inhibitory cross-talk between endothelin and ErbB receptors in the adult heart. Molecular Pharmacology. 71: 1494-502. PMID 17332141 DOI: 10.1124/mol.106.027599  1
2006 Wang H, Grant JE, Doede CM, Sadayappan S, Robbins J, Walker JW. PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. Journal of Molecular and Cellular Cardiology. 41: 823-33. PMID 17010989 DOI: 10.1016/j.yjmcc.2006.08.016  1
2006 Evans NJ, Walker JW. Endothelin-1 mobilizes profilin-1-bound PIP2 in cardiac muscle. Experimental Biology and Medicine (Maywood, N.J.). 231: 882-7. PMID 16741017  1
2006 Kang M, Walker JW. Endothelin-1 and PKC induce positive inotropy without affecting pHi in ventricular myocytes. Experimental Biology and Medicine (Maywood, N.J.). 231: 865-70. PMID 16741014  1
2006 Walker JW. Protein kinase C, troponin I and heart failure: overexpressed, hyperphosphorylated and underappreciated? Journal of Molecular and Cellular Cardiology. 40: 446-50. PMID 16519895 DOI: 10.1016/j.yjmcc.2006.01.013  1
2005 Robia SL, Kang M, Walker JW. Novel determinant of PKC-epsilon anchoring at cardiac Z-lines. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1941-50. PMID 15964917 DOI: 10.1152/ajpheart.01111.2004  1
2005 Kang M, Walker JW. Protein kinase C delta and epsilon mediate positive inotropy in adult ventricular myocytes. Journal of Molecular and Cellular Cardiology. 38: 753-64. PMID 15850569 DOI: 10.1016/j.yjmcc.2005.02.017  1
2004 Olsson MC, Patel JR, Fitzsimons DP, Walker JW, Moss RL. Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development. American Journal of Physiology. Heart and Circulatory Physiology. 287: H2712-8. PMID 15331360 DOI: 10.1152/ajpheart.01067.2003  1
2004 Huang X, Walker JW. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. Journal of Cell Science. 117: 1971-8. PMID 15039458 DOI: 10.1242/jcs.01044  1
2004 Foell JD, Balijepalli RC, Delisle BP, Yunker AM, Robia SL, Walker JW, McEnery MW, January CT, Kamp TJ. Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. Physiological Genomics. 17: 183-200. PMID 14762176 DOI: 10.1152/physiolgenomics.00207.2003  1
2004 Zhu X, Ghanta J, Walker JW, Allen PD, Valdivia HH. The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain. Cell Calcium. 35: 165-77. PMID 14706290 DOI: 10.1016/j.ceca.2003.09.002  1
2003 Robu VG, Pfeiffer ES, Robia SL, Balijepalli RC, Pi Y, Kamp TJ, Walker JW. Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. The Journal of Biological Chemistry. 278: 48154-61. PMID 12972433 DOI: 10.1074/jbc.M304396200  1
2003 Pi Y, Zhang D, Kemnitz KR, Wang H, Walker JW. Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium. The Journal of Physiology. 552: 845-57. PMID 12923217 DOI: 10.1113/jphysiol.2003.045260  1
2002 Pi Y, Kemnitz KR, Zhang D, Kranias EG, Walker JW. Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice. Circulation Research. 90: 649-56. PMID 11934831 DOI: 10.1161/01.RES.0000014080.82861.5F  1
2001 Lu Z, Swartz DR, Metzger JM, Moss RL, Walker JW. Regulation of force development studied by photolysis of caged ADP in rabbit skinned psoas fibers Biophysical Journal. 81: 334-344. PMID 11423418  1
2001 Robia SL, Ghanta J, Robu VG, Walker JW. Localization and kinetics of protein kinase C-epsilon anchoring in cardiac myocytes Biophysical Journal. 80: 2140-2151. PMID 11325717  1
2000 Pi Y, Walker JW. Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC American Journal of Physiology - Heart and Circulatory Physiology. 279: H26-H34. PMID 10899038  1
2000 He JQ, Pi YQ, Walker JW, Kamp TJ. Endothelin-1 and photoreleased diacylglycerol increase L-type Ca2+ current by activation of protein kinase C in rat ventricular myocytes Journal of Physiology. 524: 807-820. PMID 10790160  1
1999 Marriott G, Walker JW. Caged peptides and proteins: new probes to study polypeptide function in complex biological systems. Trends in Plant Science. 4: 330-334. PMID 10431224  0.01
1999 Zhu X, Gurrola G, Jiang MT, Walker JW, Valdivia HH. Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors. Febs Letters. 450: 221-6. PMID 10359078 DOI: 10.1016/S0014-5793(99)00496-2  1
1999 Gurrola GB, Arévalo C, Sreekumar R, Lokuta AJ, Walker JW, Valdivia HH. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor. The Journal of Biological Chemistry. 274: 7879-86. PMID 10075681 DOI: 10.1074/jbc.274.12.7879  1
1999 Huang X, Pi Y, Lee KJ, Henkel AS, Gregg RG, Powers PA, Walker JW. Cardiac troponin I gene knockout: A mouse model of myocardial troponin I deficiency Circulation Research. 84: 1-8. PMID 9915769  1
1998 Pi Y, Walker JW. Role of intracellular Caand pH in positive inotropic response of cardiomyocytes to diacylglycerol. American Journal of Physiology. Heart and Circulatory Physiology. 275: H1473-H1481. PMID 29586851 DOI: 10.1152/ajpheart.1998.275.4.H1473  1
1998 Yeqing PI, Walker JW. Role of intracellular Ca2+ and pH in positive inotropic response of cardiomyocytes to diacylglycerol American Journal of Physiology - Heart and Circulatory Physiology. 275: H1473-H1481. PMID 9746499  1
1998 Sreekumar R, Ikebe M, Fay FS, Walker JW. Biologically active peptides caged on tyrosine Methods in Enzymology. 291: 78-94. PMID 9661146 DOI: 10.1016/S0076-6879(98)91008-4  1
1998 Walker JW, Gilbert SH, Drummond RM, Yamada M, Sreekumar R, Carraway RE, Ikebe M, Fay FS. Signaling pathways underlying eosinophil cell motility revealed by using caged peptides Proceedings of the National Academy of Sciences of the United States of America. 95: 1568-1573. PMID 9465056 DOI: 10.1073/pnas.95.4.1568  1
1997 Huang XP, Pi Y, Lokuta AJ, Greaser ML, Walker JW. Arachidonic acid stimulates protein kinase C-ε redistribution in heart cells Journal of Cell Science. 110: 1625-1633. PMID 9247196  1
1997 Pi Y, Sreekumar R, Huang X, Walker JW. Positive inotropy mediated by diacylglycerol in rat ventricular myocytes Circulation Research. 81: 92-100. PMID 9201032  1
1996 Huang XP, Sreekumar R, Patel JR, Walker JW. Response of cardiac myocytes to a ramp increase of diacylglycerol generated by photolysis of a novel caged diacylglycerol Biophysical Journal. 70: 2448-2457. PMID 9172772  1
1996 Araujo A, Walker JW. Phosphate release and force generation in cardiac myocytes investigated with caged phosphate and caged calcium Biophysical Journal. 70: 2316-2326. PMID 9172755  1
1994 Araujo A, Walker JW. Kinetics of tension development in skinned cardiac myocytes measured by photorelease of Ca2+ American Journal of Physiology - Heart and Circulatory Physiology. 267: H1643-H1653. PMID 7977795  1
1993 Lu Z, Moss RL, Walker JW. Tension transients initiated by photogeneration of MgADP in skinned skeletal muscle fibers Journal of General Physiology. 101: 867-888. PMID 8331322  1
1993 Walker JW, Martin H, Schmitt FR, Barsotti RJ. Rapid release of an alpha-adrenergic receptor ligand from photolabile analogues. Biochemistry. 32: 1338-45. PMID 8095406  0.01
1992 Walker JW, Lu Z, Moss RL. Effects of Ca2+ on the kinetics of phosphate release in skeletal muscle Journal of Biological Chemistry. 267: 2459-2466. PMID 1733945  1
1990 Ogden DC, Capiod T, Walker JW, Trentham DR. Kinetics of the conductance evoked by noradrenaline, inositol trisphosphate or Ca2+ in guinea-pig isolated hepatocytes. The Journal of Physiology. 422: 585-602. PMID 2161925 DOI: 10.1113/jphysiol.1990.sp018002  1
1989 Walker JW, Feeney J, Trentham DR. Photolabile precursors of inositol phosphates. Preparation and properties of 1-(2-nitrophenyl)ethyl esters of myo-inositol 1,4,5-trisphosphate. Biochemistry. 28: 3272-80. PMID 2787165  1
1989 Walker JW, Reid GP, Trentham DR. Synthesis and properties of caged nucleotides. Methods in Enzymology. 172: 288-301. PMID 2747531  1
1988 Dantzig JA, Walker JW, Trentham DR, Goldman YE. Relaxation of muscle fibers with adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]) and by laser photolysis of caged ATP[gamma S]: evidence for Ca2+-dependent affinity of rapidly detaching zero-force cross-bridges. Proceedings of the National Academy of Sciences of the United States of America. 85: 6716-20. PMID 3413119  1
1988 Somlyo AP, Walker JW, Goldman YE, Trentham DR, Kobayashi S, Kitazawa T, Somlyo AV. Inositol trisphosphate, calcium and muscle contraction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 320: 399-414. PMID 2906146  1
1987 Walker JW, Somlyo AV, Goldman YE, Somlyo AP, Trentham DR. Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. Nature. 327: 249-52. PMID 3494954 DOI: 10.1038/327249a0  1
1987 Somlyo AP, Somlyo AV, Bond M, Broderick R, Goldman YE, Shuman H, Walker JW, Trentham DR. Calcium and magnesium movements in cells and the role of inositol trisphosphate in muscle. Society of General Physiologists Series. 42: 77-92. PMID 3333196  1
1986 Walker JW, McCray JA, Hess GP. Photolabile protecting groups for an acetylcholine receptor ligand. Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function. Biochemistry. 25: 1799-805. PMID 3707910  1
1984 McNamee M, Richardson C, Walker J. Activation and Inactivation Kinetics of Torpedo californica Acetylcholine Receptor in Reconstituted Membranes. Biophysical Journal. 45: 18-20. PMID 19431548 DOI: 10.1016/S0006-3495(84)84091-6  0.01
1984 Walker JW, Richardson CA, McNamee MG. Effects of thio-group modifications of Torpedo californica acetylcholine receptor on ion flux activation and inactivation kinetics. Biochemistry. 23: 2329-38. PMID 6089867  1
1982 Hess GP, Pasquale EB, Walker JW, McNamee MG. Comparison of acetylcholine receptor-controlled cation flux in membrane vesicles from Torpedo californica and Electrophorus electricus: chemical kinetic measurements in the millisecond region. Proceedings of the National Academy of Sciences of the United States of America. 79: 963-7. PMID 6951180  1
1982 Walker JW, Takeyasu K, McNamee MG. Activation and inactivation kinetics of Torpedo californica acetylcholine receptor in reconstituted membranes. Biochemistry. 21: 5384-9. PMID 6293538  1
1981 Walker JW, McNamee MG, Pasquale E, Cash DJ, Hess GP. Acetylcholine receptor inactivation in Torpedo californica electroplax membrane vesicles. Detection of two processes in the millisecond and second time regions. Biochemical and Biophysical Research Communications. 100: 86-90. PMID 7259763 DOI: 10.1016/S0006-291X(81)80066-6  1
1981 Walker JW, Lukas RJ, McNamee MG. Effects of thio-group modifications on the ion permeability control and ligand binding properties of Torpedo californica acetylcholine receptor. Biochemistry. 20: 2191-9. PMID 7236589  1
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