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Mayank Aggarwal, Ph.D. - Publications

Affiliations: 
2013 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Biochemistry, Pharmacology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Murray A, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Structural Mapping of Anion inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. Chemmedchem. PMID 30088334 DOI: 10.1002/cmdc.201800375  0.592
2018 Kovalevsky A, Aggarwal M, Velazquez H, Cuneo MJ, Blakeley MP, Weiss KL, Smith JC, Fisher SZ, McKenna R. "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure (London, England : 1993). PMID 29429876 DOI: 10.1016/J.Str.2018.01.006  0.753
2018 Murray AB, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Structural Mapping of Anion Inhibitors to beta-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. Chemmedchem. 13: 2024-2029. DOI: 10.2210/Pdb6D2N/Pdb  0.642
2018 Murray AB, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Cover Feature: Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa (ChemMedChem 19/2018) Chemmedchem. 13: 2013-2013. DOI: 10.1002/Cmdc.201800628  0.529
2016 Aggarwal M, Kovalevsky AY, Velazquez H, Fisher SZ, Smith JC, McKenna R. Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. Iucrj. 3: 319-325. PMID 28461893 DOI: 10.1107/S2052252516010514  0.795
2016 Pinard MA, Kurian JJ, Aggarwal M, Agbandje-McKenna M, McKenna R. Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3. Acta Crystallographica. Section F, Structural Biology Communications. 72: 573-7. PMID 27380376 DOI: 10.1107/S2053230X16009286  0.627
2016 Aggarwal M, Kovalevsky AY, Velazquez H, Fisher SZ, Smith JC, McKenna R. Neutron structure of human carbonic anhydrase II in complex with methazolamide: Mapping the solvent and hydrogen-bonding patterns of an effective clinical drug Iucrj. 3: 319-325. DOI: 10.1107/S2052252516010514  0.775
2015 Aggarwal M, McKenna R. Carbonic Anhydrases: Nature's Way to Balance CO2 Concentration. Biochemistry & Molecular Biology Journal. 1. PMID 28317035 DOI: 10.21767/2471-8084.100008  0.446
2015 Aggarwal M, Chua TK, Pinard MA, Szebenyi DM, McKenna R. Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase. Biochemistry. 54: 6631-8. PMID 26457866 DOI: 10.1021/Acs.Biochem.5B00987  0.655
2015 Pinard MA, Aggarwal M, Mahon BP, Tu C, McKenna R. A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1352-8. PMID 26457530 DOI: 10.1107/S2053230X1501239X  0.649
2015 Pinard MA, Aggarwal M, Mahon BP, Tu C, Mckenna R. A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX Acta Crystallographica Section:F Structural Biology Communications. 71: 1352-1358. DOI: 10.1107/S2053230X1501239X  0.453
2015 Aggarwal M, Chua TK, Pinard MA, Szebenyi DM, McKenna R. Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase Biochemistry. 54: 6631-6638. DOI: 10.1021/acs.biochem.5b00987  0.468
2014 Pala N, Micheletto L, Sechi M, Aggarwal M, Carta F, McKenna R, Supuran CT. Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. Acs Medicinal Chemistry Letters. 5: 927-30. PMID 25147616 DOI: 10.1021/Ml500196T  0.647
2014 Aggarwal M, Kondeti B, Tu C, Maupin CM, Silverman DN, McKenna R. Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. Iucrj. 1: 129-35. PMID 25075329 DOI: 10.1107/S2052252514004096  0.698
2014 Aggarwal M, Tu C, Silverman D, McKenna R. Insights into Activity Enhancement of H64A Carbonic Anhydrase by Imidazoles Acta Crystallographica Section a Foundations and Advances. 70: C803-C803. DOI: 10.1107/S2053273314091967  0.674
2013 Aggarwal M, Boone CD, Kondeti B, Tu C, Silverman DN, McKenna R. Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex. Acta Crystallographica. Section D, Biological Crystallography. 69: 860-5. PMID 23633596 DOI: 10.1107/S0907444913002771  0.691
2013 Aggarwal M, Kondeti B, McKenna R. Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 23: 717-24. PMID 23514045 DOI: 10.1517/13543776.2013.782394  0.494
2013 Mikulski R, West D, Sippel KH, Avvaru BS, Aggarwal M, Tu C, McKenna R, Silverman DN. Water networks in fast proton transfer during catalysis by human carbonic anhydrase II. Biochemistry. 52: 125-31. PMID 23215152 DOI: 10.1021/Bi301099K  0.707
2013 Aggarwal M, Boone CD, Kondeti B, McKenna R. Structural annotation of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 267-77. PMID 23137351 DOI: 10.3109/14756366.2012.737323  0.648
2013 Aggarwal M, Kondeti B, McKenna R. Insights towards sulfonamide drug specificity in α-carbonic anhydrases. Bioorganic & Medicinal Chemistry. 21: 1526-33. PMID 22985956 DOI: 10.1016/J.Bmc.2012.08.019  0.616
2013 Aggarwal M, Kovalevsky A, McKenna R, Silverman D, Fisher Z. Neutron protein crystallography reveals unique details of clinical drug binding to a human target enzyme Neutron News. 24: 20-23. DOI: 10.1080/10448632.2013.831317  0.526
2012 Marini AM, Maresca A, Aggarwal M, Orlandini E, Nencetti S, Da Settimo F, Salerno S, Simorini F, La Motta C, Taliani S, Nuti E, Scozzafava A, McKenna R, Rossello A, Supuran CT. Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms. Journal of Medicinal Chemistry. 55: 9619-29. PMID 23067387 DOI: 10.1021/Jm300878G  0.646
2012 Fisher SZ, Aggarwal M, Kovalevsky AY, Silverman DN, McKenna R. Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. Journal of the American Chemical Society. 134: 14726-9. PMID 22928733 DOI: 10.1021/Ja3068098  0.78
2012 Aggarwal M, McKenna R. Update on carbonic anhydrase inhibitors: a patent review (2008 - 2011). Expert Opinion On Therapeutic Patents. 22: 903-15. PMID 22788994 DOI: 10.1517/13543776.2012.707646  0.577
2012 Fisher Z, Boone CD, Biswas SM, Venkatakrishnan B, Aggarwal M, Tu C, Agbandje-McKenna M, Silverman D, McKenna R. Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Engineering, Design & Selection : Peds. 25: 347-55. PMID 22691706 DOI: 10.1093/Protein/Gzs027  0.714
2012 Stridh MH, Alt MD, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, Seidler U, Wennemuth G, McKenna R, Deitmer JW, Becker HM. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. The Journal of Physiology. 590: 2333-51. PMID 22451434 DOI: 10.1113/Jphysiol.2011.220152  0.512
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Masini E, Supuran CT. Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo. Journal of Medicinal Chemistry. 55: 1721-30. PMID 22276570 DOI: 10.1021/Jm300031J  0.681
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Supuran CT. Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chemical Communications (Cambridge, England). 48: 1868-70. PMID 22218610 DOI: 10.1039/C2Cc16395K  0.631
2011 Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT. Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry. 19: 3732-8. PMID 21620713 DOI: 10.1016/J.Bmc.2011.05.006  0.701
2011 Hen N, Bialer M, Yagen B, Maresca A, Aggarwal M, Robbins AH, McKenna R, Scozzafava A, Supuran CT. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. Journal of Medicinal Chemistry. 54: 3977-81. PMID 21506569 DOI: 10.1021/Jm200209N  0.669
2010 Pacchiano F, Aggarwal M, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT. Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chemical Communications (Cambridge, England). 46: 8371-3. PMID 20922253 DOI: 10.1039/C0Cc02707C  0.785
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