Andrew T. Gewirtz - Publications

Affiliations: 
Biological and Biomedical Sciences Emory University, Atlanta, GA 
Area:
Immunology, Virology Biology, Public Health

205 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ngo VL, Lieber CM, Kang HJ, Sakamoto K, Kuczma M, Plemper RK, Gewirtz AT. Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection. Biorxiv : the Preprint Server For Biology. PMID 37790571 DOI: 10.1101/2023.09.21.558814  0.31
2023 Kordahi MC, Delaroque C, Bredèche MF, Gewirtz AT, Chassaing B. Vaccination against microbiota motility protects mice from the detrimental impact of dietary emulsifier consumption. Plos Biology. 21: e3002289. PMID 37725584 DOI: 10.1371/journal.pbio.3002289  0.347
2020 Viennois E, Bretin A, Dubé PE, Maue AC, Dauriat CJG, Barnich N, Gewirtz AT, Chassaing B. Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation. Cell Reports. 33: 108229. PMID 33027647 DOI: 10.1016/j.celrep.2020.108229  0.306
2020 Zou J, Zhao X, Shi Z, Zhang Z, Vijay-Kumar M, Chassaing B, Gewirtz AT. Critical role of innate immunity to flagellin in absence of adaptive immunity. The Journal of Infectious Diseases. PMID 32830227 DOI: 10.1093/Infdis/Jiaa521  0.334
2020 Powell DN, Swimm A, Sonowal R, Bretin A, Gewirtz AT, Jones RM, Kalman D. Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817517 DOI: 10.1073/Pnas.2003004117  0.383
2020 Johnson EL, Heaver SL, Waters JL, Kim BI, Bretin A, Goodman AL, Gewirtz AT, Worgall TS, Ley RE. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nature Communications. 11: 2471. PMID 32424203 DOI: 10.1038/S41467-020-16274-W  0.329
2020 Golonka RM, Saha P, Yeoh BS, Chattopadhay S, Gewirtz AT, Joe B, Vijay-Kumar M. Harnessing Innate Immunity to Eliminate SARS-CoV-2 and Ameliorate COVID-19 Disease. Physiological Genomics. PMID 32275178 DOI: 10.1152/Physiolgenomics.00033.2020  0.322
2020 Adeshirlarijaney A, Gewirtz AT. Considering gut microbiota in treatment of type 2 diabetes mellitus. Gut Microbes. 1-12. PMID 32005089 DOI: 10.1080/19490976.2020.1717719  0.301
2020 Mills RH, Wozniak JM, Vrbanac A, Campeau A, Chassaing B, Gewirtz A, Knight R, Gonzalez DJ. Organ level protein networks as a reference for the host effects of the microbiome. Genome Research. PMID 31992612 DOI: 10.1101/Gr.256875.119  0.305
2020 Abo H, Chassaing B, Harusato A, Quiros M, Brazil JC, Ngo VL, Viennois E, Merlin D, Gewirtz AT, Nusrat A, Denning TL. Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration. Nature Communications. 11: 513. PMID 31980634 DOI: 10.1038/S41467-019-14258-Z  0.38
2020 Mills R, Dulai P, Vázquez-Baeza Y, Zhu Q, Humphrey G, DeRight Goldasich L, Quinn R, Gewirtz A, Chassaing B, Chu H, Sandborn W, Dorrestein P, Knight R, Gonzalez D. OP31 Meta–omics reveals microbiome-driven proteolysis as a contributing factor to the severity of ulcerative colitis disease activity Journal of Crohn's and Colitis. 14: S030-S031. DOI: 10.1093/Ecco-Jcc/Jjz203.030  0.349
2020 Bretin A, Zou J, Pellizzon M, Chassaing B, Gewirtz AT. Tu1260 PSYLLIUM FIBER INDUCES UNIQUE CHANGES IN MICROBIOTA AND COLON GENE EXPRESSION, CHANGES THAT MEDIATE ITS PROTECTION AGAINST INFLAMMATION AND METABOLIC SYNDROME Gastroenterology. 158: S-1035-S-1036. DOI: 10.1016/S0016-5085(20)33270-4  0.322
2019 Tran HQ, Ley RE, Gewirtz AT, Chassaing B. Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases. Nature Communications. 10: 5650. PMID 31827095 DOI: 10.1038/S41467-019-13538-Y  0.407
2019 Rolhion N, Chassaing B, Nahori MA, de Bodt J, Moura A, Lecuit M, Dussurget O, Bérard M, Marzorati M, Fehlner-Peach H, Littman DR, Gewirtz AT, Van de Wiele T, Cossart P. A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection. Cell Host & Microbe. 26: 691-701.e5. PMID 31726031 DOI: 10.1016/J.Chom.2019.10.016  0.376
2019 Hagan T, Cortese M, Rouphael N, Boudreau C, Linde C, Maddur MS, Das J, Wang H, Guthmiller J, Zheng NY, Huang M, Uphadhyay AA, Gardinassi L, Petitdemange C, McCullough MP, ... ... Gewirtz AT, et al. Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell. 178: 1313-1328.e13. PMID 31491384 DOI: 10.1016/J.Cell.2019.08.010  0.362
2019 Viennois E, Chassaing B, Tahsin A, Pujada A, Wang L, Gewirtz AT, Merlin D. Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation. Theranostics. 9: 4542-4557. PMID 31285778 DOI: 10.7150/Thno.35282  0.318
2019 Ko EJ, Lee Y, Lee YT, Jung YJ, Ngo VL, Kim MC, Kim KH, Wang BZ, Gewirtz AT, Kang SM. Flagellin-expressing virus-like particles exhibit adjuvant effects on promoting IgG isotype-switched long-lasting antibody induction and protection of influenza vaccines in CD4-deficient mice. Vaccine. PMID 31101421 DOI: 10.1016/J.Vaccine.2019.05.018  0.313
2019 Yeoh BS, Gewirtz AT, Vijay-Kumar M. Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses. Frontiers in Cellular and Infection Microbiology. 9: 29. PMID 30838179 DOI: 10.3389/Fcimb.2019.00029  0.404
2019 Viennois E, Gewirtz AT, Chassaing B. Chronic inflammatory diseases: Are we ready for microbiota-based dietary intervention? Cellular and Molecular Gastroenterology and Hepatology. PMID 30836147 DOI: 10.1016/J.Jcmgh.2019.02.008  0.353
2019 Harusato A, Viennois E, Etienne-Mesmin L, Matsuyama S, Abo H, Osuka S, Lukacs NW, Naito Y, Itoh Y, Li JD, Merlin D, Gewirtz AT, Denning TL. Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumorigenesis. Cancer Immunology Research. PMID 30782668 DOI: 10.1158/2326-6066.Cir-18-0444  0.399
2019 Singh V, Yeoh BS, Walker RE, Xiao X, Saha P, Golonka RM, Cai J, Bretin ACA, Cheng X, Liu Q, Flythe MD, Chassaing B, Shearer GC, Patterson AD, Gewirtz AT, et al. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. Gut. PMID 30670576 DOI: 10.1136/Gutjnl-2018-316250  0.365
2018 Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature. 560: 489-493. PMID 30089902 DOI: 10.1038/S41586-018-0395-5  0.397
2018 Chassaing B, Gewirtz AT. Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency. Plos One. 13: e0195310. PMID 29617463 DOI: 10.1371/Journal.Pone.0195310  0.425
2018 Chassaing B, Gewirtz AT. Not so Splendid for the Gut Microbiota. Inflammatory Bowel Diseases. PMID 29554295 DOI: 10.1093/Ibd/Izy072  0.367
2018 Shi Z, Gewirtz AT. Together Forever: Bacterial-Viral Interactions in Infection and Immunity. Viruses. 10. PMID 29534424 DOI: 10.3390/V10030122  0.366
2018 Fields CT, Chassaing B, Castillo-Ruiz A, Osan R, Gewirtz AT, de Vries GJ. Effects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice. Biology of Sex Differences. 9: 7. PMID 29351816 DOI: 10.1186/S13293-018-0166-X  0.313
2017 Zhang B, Oyewole-Said D, Zou J, Willliams IR, Gewirtz AT. TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation. Blood Advances. 1: 1796-1806. PMID 29296826 DOI: 10.1182/Bloodadvances.2017006981  0.326
2017 Zou J, Chassaing B, Singh V, Pellizzon M, Ricci M, Fythe MD, Kumar MV, Gewirtz AT. Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health. Cell Host & Microbe. PMID 29276170 DOI: 10.1016/J.Chom.2017.11.003  0.337
2017 Chassaing B, Vijay-Kumar M, Gewirtz AT. How diet can impact gut microbiota to promote or endanger health. Current Opinion in Gastroenterology. 33: 417-421. PMID 29019865 DOI: 10.1097/Mog.0000000000000401  0.323
2017 Castillo-Ruiz A, Mosley M, George AJ, Mussaji LF, Fullerton EF, Ruszkowski EM, Jacobs AJ, Gewirtz AT, Chassaing B, Forger NG. The microbiota influences cell death and microglial colonization in the perinatal mouse brain. Brain, Behavior, and Immunity. PMID 28890156 DOI: 10.1016/J.Bbi.2017.08.027  0.357
2017 Chassaing B, Raja SM, Lewis JD, Srinivasan S, Gewirtz AT. Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans. Cellular and Molecular Gastroenterology and Hepatology. 4: 205-221. PMID 28649593 DOI: 10.1016/J.Jcmgh.2017.04.001  0.366
2017 Harusato A, Abo H, Ngo VL, Yi SW, Mitsutake K, Osuka S, Kohlmeier JE, Li JD, Gewirtz AT, Nusrat A, Denning TL. IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors. Mucosal Immunology. PMID 28327619 DOI: 10.1038/Mi.2017.21  0.341
2017 Chassaing B, Van de Wiele T, De Bodt J, Marzorati M, Gewirtz AT. Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation. Gut. PMID 28325746 DOI: 10.1136/Gutjnl-2016-313099  0.395
2017 Etienne-Mesmin L, Chassaing B, Gewirtz AT. Tryptophan: A gut microbiota-derived metabolites regulating inflammation. World Journal of Gastrointestinal Pharmacology and Therapeutics. 8: 7-9. PMID 28217370 DOI: 10.4292/Wjgpt.V8.I1.7  0.411
2017 Chassaing B, Van de Wiele T, Gewirtz A. O-013 Dietary Emulsifiers Directly Impact the Human Gut Microbiota Increasing Its Pro-inflammatory Potential and Ability to Induce Intestinal Inflammation. Inflammatory Bowel Diseases. 23: S5. PMID 28125561 DOI: 10.1097/01.Mib.0000512523.29952.6F  0.398
2017 Viennois E, Chassaing B, Gewirtz AT, Merlin D. Pept1-Knock Out Mice Harbor a Protective Microbiota Beneficial Against Colitis and Colitis-Associated Cancer Gastroenterology. 152: S154. DOI: 10.1016/S0016-5085(17)30839-9  0.321
2017 Chassaing B, Gewirtz AT. Pathobiont-Free Microbiota Protects Against Gut Inflammation Induced by an Innate Immune Deficiency or Dietary Perturbant of the Microbiota Gastroenterology. 152: S32. DOI: 10.1016/S0016-5085(17)30473-0  0.404
2016 Etienne-Mesmin L, Vijay-Kumar M, Gewirtz AT, Chassaing B. Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease. Cellular and Molecular Gastroenterology and Hepatology. 2: 584-604. PMID 28090564 DOI: 10.1016/J.Jcmgh.2016.04.007  0.37
2016 Reichardt F, Chassaing B, Nezami BG, Li G, Tabatabavakili S, Mwangi S, Uppal K, Liang B, Vijay-Kumar M, Jones D, Gewirtz AT, Srinivasan S. Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and LPS-induced TLR4 signaling. The Journal of Physiology. PMID 28000223 DOI: 10.1113/Jp273269  0.356
2016 Floyd M, Winn M, Cullen C, Sil P, Chassaing B, Yoo DG, Gewirtz AT, Goldberg JB, McCarter LL, Rada B. Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa. Plos Pathogens. 12: e1005987. PMID 27855208 DOI: 10.1371/Journal.Ppat.1005987  0.351
2016 Viennois E, Merlin D, Gewirtz AT, Chassaing B. Dietary emulsifier-induced low-grade inflammation promotes colon carcinogenesis. Cancer Research. PMID 27821485 DOI: 10.1158/0008-5472.Can-16-1359  0.364
2016 Kanhere M, Chassaing B, Gewirtz AT, Tangpricha V. Role of vitamin D on gut microbiota in cystic fibrosis. The Journal of Steroid Biochemistry and Molecular Biology. PMID 27818276 DOI: 10.1016/J.Jsbmb.2016.11.001  0.313
2016 Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, et al. Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil. Plos One. 11: e0158772. PMID 27690129 DOI: 10.1371/Journal.Pone.0158772  0.304
2016 Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL. IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria. Mucosal Immunology. PMID 27624780 DOI: 10.1038/Mi.2016.80  0.373
2016 Bian Z, Shi L, Guo YL, Lv Z, Tang C, Niu S, Tremblay A, Venkataramani M, Culpepper C, Li L, Zhou Z, Mansour A, Zhang Y, Gewirtz A, Kidder K, et al. Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27578867 DOI: 10.1073/Pnas.1521069113  0.337
2016 Singh V, Yeoh BS, Chassaing B, Zhang B, Saha P, Xiao X, Awasthi D, Shashidharamurthy R, Dikshit M, Gewirtz A, Vijay-Kumar M. Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis. Cellular and Molecular Gastroenterology and Hepatology. 2: 482-498.e6. PMID 27458605 DOI: 10.1016/J.Jcmgh.2016.03.007  0.419
2016 Anitha M, Reichardt F, Tabatabavakili S, Nezami BG, Chassaing B, Mwangi S, Vijay-Kumar M, Gewirtz A, Srinivasan S. Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice. Cellular and Molecular Gastroenterology and Hepatology. 2: 328-339. PMID 27446985 DOI: 10.1016/J.Jcmgh.2015.12.008  0.319
2016 Ley RE, Gewirtz AT. Corralling Colonic Flagellated Microbiota. The New England Journal of Medicine. 375: 85-7. PMID 27406353 DOI: 10.1056/Nejmcibr1604801  0.343
2016 Li JY, Chassaing B, Tyagi AM, Vaccaro C, Luo T, Adams J, Darby TM, Weitzmann MN, Mulle JG, Gewirtz AT, Jones RM, Pacifici R. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. The Journal of Clinical Investigation. PMID 27111232 DOI: 10.1172/Jci86062  0.356
2016 Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, et al. Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell. 164: 827-828. PMID 26919416 DOI: 10.1016/J.Cell.2016.02.015  0.32
2016 Chassaing B, Gewirtz AT. Has provoking microbiota aggression driven the obesity epidemic? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 38: 122-8. PMID 26749135 DOI: 10.1002/Bies.201500116  0.326
2016 Chassaing B, Tran H, Gewirtz AT. Su1885 Colitis Vaccine: Flagellin-Elicited Immunity Keeps Motile Bacteria In-Check and Protects Against Intestinal Inflammation Gastroenterology. 150: S579. DOI: 10.1016/S0016-5085(16)31984-9  0.339
2016 Chassaing B, van De Wiele T, Gewirtz AT. 88 Dietary Emulsifiers Directly Impact the Human Gut Microbiota Increasing Its Pro-Inflammatory Potential Gastroenterology. 150: S22. DOI: 10.1016/S0016-5085(16)30199-8  0.347
2015 Gewirtz AT. Deciphering the Role of Mesenteric Fat in Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology. 1: 352-353. PMID 28210686 DOI: 10.1016/J.Jcmgh.2015.05.004  0.311
2015 Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT, Williams IR. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunology. PMID 26601902 DOI: 10.1038/Mi.2015.121  0.383
2015 Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, et al. Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. Journal of Immunology (Baltimore, Md. : 1950). PMID 26590314 DOI: 10.4049/Jimmunol.1501312  0.332
2015 Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, ... ... Gewirtz AT, et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. Cell Metabolism. PMID 26525535 DOI: 10.1016/J.Cmet.2015.09.028  0.328
2015 Chassaing B, Miles-Brown J, Pellizzon M, Ulman E, Ricci M, Zhang L, Patterson AD, Vijay-Kumar M, Gewirtz AT. Lack of soluble fiber drives diet-induced adiposity in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G528-41. PMID 26185332 DOI: 10.1152/Ajpgi.00172.2015  0.32
2015 Singh V, Yeoh BS, Carvalho F, Gewirtz AT, Vijay-Kumar M. Proneness of TLR5 Deficient Mice to Develop Colitis is Microbiota Dependent. Gut Microbes. 0. PMID 26067589 DOI: 10.1080/19490976.2015.1060390  0.401
2015 Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 519: 92-6. PMID 25731162 DOI: 10.1038/Nature14232  0.39
2015 Thapa M, Chinnadurai R, Velazquez VM, Tedesco D, Elrod E, Han JH, Sharma P, Ibegbu C, Gewirtz A, Anania F, Pulendran B, Suthar MS, Grakoui A. Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity. Hepatology (Baltimore, Md.). 61: 2067-79. PMID 25711908 DOI: 10.1002/Hep.27761  0.347
2015 Uchiyama R, Chassaing B, Zhang B, Gewirtz AT. MyD88-mediated TLR signaling protects against acute rotavirus infection while inflammasome cytokines direct Ab response. Innate Immunity. 21: 416-28. PMID 25213347 DOI: 10.1177/1753425914547435  0.41
2015 Galloway DP, Troutt ML, Kocoshis SA, Gewirtz AT, Ziegler TR, Cole CR. Increased Anti-Flagellin and Anti-Lipopolysaccharide Immunoglobulins in Pediatric Intestinal Failure: Associations With Fever and Central Line-Associated Bloodstream Infections. Jpen. Journal of Parenteral and Enteral Nutrition. 39: 562-8. PMID 24898211 DOI: 10.1177/0148607114537073  0.308
2015 Etienne-Mesmin L, Chassaing B, Gewirtz AT. Su1802 Hepatocyte TLR5 Protects Against Bacterial Infection and High-Fat Diet Induced Liver Disease Gastroenterology. 148: S-1054-S-1055. DOI: 10.1016/S0016-5085(15)33599-X  0.324
2014 Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science (New York, N.Y.). 346: 861-5. PMID 25395539 DOI: 10.1126/Science.1256999  0.391
2014 Leifer CA, McConkey C, Li S, Chassaing B, Gewirtz AT, Ley RE. Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation. Immunology Letters. 162: 3-9. PMID 25284610 DOI: 10.1016/J.Imlet.2014.07.017  0.409
2014 Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity. 41: 478-92. PMID 25220212 DOI: 10.1016/J.Immuni.2014.08.009  0.325
2014 Chassaing B, Ley RE, Gewirtz AT. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology. 147: 1363-77.e17. PMID 25172014 DOI: 10.1053/J.Gastro.2014.08.033  0.407
2014 Hossain MS, Ramachandiran S, Gewirtz AT, Waller EK. Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. Plos One. 9: e96165. PMID 24879439 DOI: 10.1371/Journal.Pone.0096165  0.412
2014 Xiao B, Laroui H, Viennois E, Ayyadurai S, Charania MA, Zhang Y, Zhang Z, Baker MT, Zhang B, Gewirtz AT, Merlin D. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology. 146: 1289-300.e1-19. PMID 24503126 DOI: 10.1053/J.Gastro.2014.01.056  0.303
2014 Uchiyama R, Chassaing B, Zhang B, Gewirtz AT. Antibiotic treatment suppresses rotavirus infection and enhances specific humoral immunity. The Journal of Infectious Diseases. 210: 171-82. PMID 24436449 DOI: 10.1093/Infdis/Jiu037  0.307
2014 Chassaing B, Gewirtz AT. Gut microbiota, low-grade inflammation, and metabolic syndrome. Toxicologic Pathology. 42: 49-53. PMID 24285672 DOI: 10.1177/0192623313508481  0.379
2014 Chassaing B, Koren O, Carvalho FA, Ley RE, Gewirtz AT. AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition. Gut. 63: 1069-80. PMID 23896971 DOI: 10.1136/Gutjnl-2013-304909  0.426
2014 Chassaing B, Etienne-Mesmin L, Gewirtz AT. Microbiota-liver axis in hepatic disease. Hepatology (Baltimore, Md.). 59: 328-39. PMID 23703735 DOI: 10.1002/Hep.26494  0.329
2014 Chassaing B, Gewirtz AT. Sa1745 Food Additives Promote Intestinal Inflammation in Susceptible Hosts Gastroenterology. 146: S-286. DOI: 10.1016/S0016-5085(14)61016-7  0.331
2014 Chassaing B, Gewirtz AT. Sa1723 Role of Intestinal Epithelial Cell, Dendritic Cell, and Hepatocyte TLR5 in Keeping the Microbiota In-check and Protecting the Gut Gastroenterology. 146: S-281-S-282. DOI: 10.1016/S0016-5085(14)60994-X  0.386
2014 Uchiyama R, Gewirtz AT. 74 Antibiotic Treatment Suppresses Rotavirus Infection and Enhances RV-Specific Immunity Gastroenterology. 146: S-21. DOI: 10.1016/S0016-5085(14)60074-3  0.3
2014 Uchiyama R, Gewirtz AT. 21 MyD88 Is Important for Rotavirus Infection Containment and Specific Adaptive Responses Gastroenterology. 146: S-7. DOI: 10.1016/S0016-5085(14)60021-4  0.413
2013 Cullender TC, Chassaing B, Janzon A, Kumar K, Muller CE, Werner JJ, Angenent LT, Bell ME, Hay AG, Peterson DA, Walter J, Vijay-Kumar M, Gewirtz AT, Ley RE. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host & Microbe. 14: 571-81. PMID 24237702 DOI: 10.1016/J.Chom.2013.10.009  0.421
2013 Ursell LK, Van Treuren W, Metcalf JL, Pirrung M, Gewirtz A, Knight R. Replenishing our defensive microbes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 810-7. PMID 23836415 DOI: 10.1002/Bies.201300018  0.305
2013 Aitken JD, Gewirtz AT. Gut microbiota in 2012: Toward understanding and manipulating the gut microbiota. Nature Reviews. Gastroenterology & Hepatology. 10: 72-4. PMID 23296245 DOI: 10.1038/Nrgastro.2012.252  0.361
2013 Norris V, Molina F, Gewirtz AT. Hypothesis: bacteria control host appetites. Journal of Bacteriology. 195: 411-6. PMID 23144247 DOI: 10.1128/Jb.01384-12  0.338
2013 Chassaing B, Koren O, Carvalho FA, Ley RE, Gewirtz AT. Tu2024 AIEC Instigates Chronic Colitis by Altering Microbiota Composition and Its Inherent Pro-Inflammatory Potential Gastroenterology. 144: S-907. DOI: 10.1016/S0016-5085(13)63380-6  0.345
2012 Chassaing B, Aitken JD, Gewirtz AT, Vijay-Kumar M. Gut microbiota drives metabolic disease in immunologically altered mice. Advances in Immunology. 116: 93-112. PMID 23063074 DOI: 10.1016/B978-0-12-394300-2.00003-X  0.373
2012 Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT, Vijay-Kumar M. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. Plos One. 7: e44328. PMID 22957064 DOI: 10.1371/Journal.Pone.0044328  0.405
2012 Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, ... ... Gewirtz AT, et al. Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host & Microbe. 12: 139-52. PMID 22863420 DOI: 10.1016/J.Chom.2012.07.004  0.422
2012 Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R, Borregaard N, Jones DP, Gewirtz AT, Vijay-Kumar M. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Journal of Immunology (Baltimore, Md. : 1950). 189: 1911-9. PMID 22786765 DOI: 10.4049/Jimmunol.1200892  0.333
2012 Anitha M, Vijay-Kumar M, Sitaraman SV, Gewirtz AT, Srinivasan S. Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology. 143: 1006-16.e4. PMID 22732731 DOI: 10.1053/J.Gastro.2012.06.034  0.348
2012 Ingersoll SA, Laroui H, Kolachala VL, Wang L, Garg P, Denning TL, Gewirtz AT, Merlin D, Sitaraman SV. A(₂B)AR expression in non-immune cells plays an important role in the development of murine colitis. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association For the Study of the Liver. 44: 819-26. PMID 22721840 DOI: 10.1016/J.Dld.2012.05.013  0.362
2012 Carvalho FA, Nalbantoglu I, Aitken JD, Uchiyama R, Su Y, Doho GH, Vijay-Kumar M, Gewirtz AT. Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. Mucosal Immunology. 5: 288-98. PMID 22318495 DOI: 10.1038/Mi.2012.8  0.439
2012 Carvalho FA, Aitken JD, Vijay-Kumar M, Gewirtz AT. Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annual Review of Physiology. 74: 177-98. PMID 22035346 DOI: 10.1146/Annurev-Physiol-020911-153330  0.385
2012 Frias AH, Jones RM, Fifadara NH, Vijay-Kumar M, Gewirtz AT. Rotavirus-induced IFN-β promotes anti-viral signaling and apoptosis that modulate viral replication in intestinal epithelial cells. Innate Immunity. 18: 294-306. PMID 21733977 DOI: 10.1177/1753425911401930  0.762
2012 Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut. 61: 373-84. PMID 21646247 DOI: 10.1136/Gut.2011.240556  0.394
2012 Hossain MS, Gewirtz AT, Waller EK. Distinct IFN-Gamma Dependent Effect of the TLR5 Agonist, Flagellin On NK and CD4+ T Cell Immunity Against CMV Blood. 120: 255-255. DOI: 10.1182/Blood.V120.21.255.255  0.41
2012 Carvalho F, Koren O, Chassaing B, Darfeuille-Michaud A, Knight R, Ley R, Gewirtz A. Colitis in TLR5-deficiency Mice: Role of the Microbiota Inflammatory Bowel Diseases. 18: S113-S114. DOI: 10.1097/00054725-201212001-00292  0.356
2012 Liu H, Patel NR, Gewirtz AT, Merlin D, Sitaraman SV, Garg P. 1073 Cell-Specific Overexpression of MMP9 in the Colonic Epithelium is Associated With Increased Level of PRO-Inflammatory Chemokine Kc, Which in Turn Mediates Inflammation in Acute Colitis Gastroenterology. 142: S-191. DOI: 10.1016/S0016-5085(12)60716-1  0.353
2011 Hossain MS, Jaye DL, Pollack BP, Farris AB, Tselanyane ML, David E, Roback JD, Gewirtz AT, Waller EK. Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 5130-40. PMID 22013117 DOI: 10.4049/Jimmunol.1101334  0.335
2011 Garg P, Jeppsson S, Dalmasso G, Ghaleb AM, McConnell BB, Yang VW, Gewirtz AT, Merlin D, Sitaraman SV. Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. Gastroenterology. 141: 1381-92. PMID 21723221 DOI: 10.1053/J.Gastro.2011.06.056  0.324
2011 Kwon S, Gewirtz AT, Hurley DJ, Robertson TP, Moore JN, Vandenplas ML. Disparities in TLR5 expression and responsiveness to flagellin in equine neutrophils and mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 186: 6263-70. PMID 21518971 DOI: 10.4049/Jimmunol.1003824  0.359
2011 Vijay-Kumar M, Aitken JD, Carvalho FA, Ziegler TR, Gewirtz AT, Ganji V. Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice. Journal of Inflammation (London, England). 8: 2. PMID 21314942 DOI: 10.1186/1476-9255-8-2  0.318
2011 Jones RM, Sloane VM, Wu H, Luo L, Kumar A, Kumar MV, Gewirtz AT, Neish AS. Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. Gut. 60: 648-57. PMID 21199832 DOI: 10.1136/Gut.2010.223891  0.362
2011 Carvalho FA, Aitken JD, Gewirtz AT, Vijay-Kumar M. TLR5 activation induces secretory interleukin-1 receptor antagonist (sIL-1Ra) and reduces inflammasome-associated tissue damage. Mucosal Immunology. 4: 102-11. PMID 20844479 DOI: 10.1038/Mi.2010.57  0.338
2011 Hossain MS, Jaye DL, Pollack BP, Farr AB, Roback J, Gewirtz AT, Waller EK. Flagellin, a TLR5 Agonist, Reduces GvHD in Allogeneic HSCT Recipients While Enhancing Anti-Viral Immunity: A Novel Therapeutic Approach Blood. 118: 144-144. DOI: 10.1182/Blood.V118.21.144.144  0.326
2011 Aitken JD, Carvalho FA, Fifadara N, Ganesh T, Gewirtz AT, Vijay-Kumar M. Lipocalin-2 Deficiency Increases Gut Bacterial Burden and Excerbates Dextran Sulfate Sodium (DSS) Induced Murine Colitis Gastroenterology. 140: S-496. DOI: 10.1016/S0016-5085(11)62051-9  0.382
2011 Garg P, Patel NR, Laroui H, Gewirtz AT, Merlin D, Sitaraman SV. Constitutive Expression of MMP-9 in Intestinal Epithelial Cells Worsens Acute Colitis in Mice Gastroenterology. 140: S-143. DOI: 10.1016/S0016-5085(11)60581-7  0.339
2011 Carvalho FA, Vijay-Kumar M, Aitken JD, Barnich N, Darfeuille-Michaud A, Gewirtz AT. Coordinate Detection of Flagellin by TLR5 and NLRC4 Mediate Rapid Clearance of AIEC LF82 and Limit Gut Inflammation Gastroenterology. 140: S-115. DOI: 10.1016/S0016-5085(11)60466-6  0.354
2011 Carvalho FA, Aitken JD, Vijay-Kumar M, Gewirtz AT. Cytosolic Flagellin Receptor NLRC4 Plays a Key Role in Host Defense Against Orally Administered Inflammation-Associated Bacteria Gastroenterology. 140: S-30. DOI: 10.1016/S0016-5085(11)60115-7  0.351
2011 Hossain M, Gewirtz A, Roback J, Waller E. Flagellin Reduces GvHD Through Early Immunosuppression Induced by the flagellin-TLR5 Immune Interaction of Host Cells in Allogeneic HSCT Recipients Biology of Blood and Marrow Transplantation. 17: S303. DOI: 10.1016/J.Bbmt.2010.12.447  0.357
2010 Vijay-Kumar M, Carvalho FA, Aitken JD, Fifadara NH, Gewirtz AT. TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. European Journal of Immunology. 40: 3528-34. PMID 21072873 DOI: 10.1002/Eji.201040421  0.407
2010 Titanji K, Velu V, Chennareddi L, Vijay-Kumar M, Gewirtz AT, Freeman GJ, Amara RR. Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. The Journal of Clinical Investigation. 120: 3878-90. PMID 20972331 DOI: 10.1172/Jci43271  0.313
2010 Castanon-Cervantes O, Wu M, Ehlen JC, Paul K, Gamble KL, Johnson RL, Besing RC, Menaker M, Gewirtz AT, Davidson AJ. Dysregulation of inflammatory responses by chronic circadian disruption. Journal of Immunology (Baltimore, Md. : 1950). 185: 5796-805. PMID 20944004 DOI: 10.4049/Jimmunol.1001026  0.35
2010 Frias AH, Vijay-Kumar M, Gentsch JR, Crawford SE, Carvalho FA, Estes MK, Gewirtz AT. Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components. Mucosal Immunology. 3: 622-32. PMID 20664578 DOI: 10.1038/Mi.2010.39  0.772
2010 Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (New York, N.Y.). 328: 228-31. PMID 20203013 DOI: 10.1126/Science.1179721  0.339
2010 Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD, Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. The Journal of Pediatrics. 156: 941-7, 947.e1. PMID 20171649 DOI: 10.1016/J.Jpeds.2009.12.008  0.354
2010 Garg P, Sarma D, Jeppsson S, Patel NR, Gewirtz AT, Merlin D, Sitaraman SV. Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Research. 70: 792-801. PMID 20068187 DOI: 10.1158/0008-5472.Can-09-3166  0.305
2010 Frias AH, Vijay-Kumar M, Jones R, Gentsch JR, Estes MK, Gewirtz AT. T1789 Intestinal Epithelia Activate Anti-Viral Signaling by Intracellular Sensing of Rotavirus Structural Components Gastroenterology. 138: S-579. DOI: 10.1016/S0016-5085(10)62667-4  0.749
2010 Kolachala VL, Denning TL, Wang L, Vijay-Kumar M, Gewirtz AT, Merlin D, Sitaraman SV. M1829 Colonic Mucosal A2BR Mediates Pro-Inflammatory Events Gastroenterology. 138: S-427. DOI: 10.1016/S0016-5085(10)61972-5  0.315
2010 Frias AH, Vijay-Kumar M, Jones R, Gewirtz AT. S1768 Epithelia Respond to Rotavirus by Producing Type 1 Ifns That Drive Antiviral Gene Expression and Apoptosis Gastroenterology. 138: S-270. DOI: 10.1016/S0016-5085(10)61238-3  0.736
2010 Carvalho FA, Vijay-Kumar M, Gewirtz AT. S1755 Cytosolic Flagellin Receptor Ipaf Plays a Key Role in Host Defense Against Orally Administered Salmonella Gastroenterology. 138: S-267. DOI: 10.1016/S0016-5085(10)61225-5  0.311
2010 Carvalho FA, Vijay-Kumar M, Gewirtz AT. S1722 Loss of TLR5 Predisposes Mice to TLR4-, Ipaf- And Helicobacter-Independent Colitis in Response to Neutralization of IL-10 Gastroenterology. 138: S-260-S-261. DOI: 10.1016/S0016-5085(10)61192-4  0.345
2010 Carvalho FA, Aitken JD, Sitaraman SV, Gewirtz AT, Vijay-Kumar M. 394 TLR5-Mediated Expression of Endogenous IL-1β Antagonist, Sil-1ra, Protects Against Inflammation Gastroenterology. 138: S-58. DOI: 10.1016/S0016-5085(10)60262-4  0.304
2010 Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi SM, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT. 279 Altered Gut Microbiota in Toll-Like Receptor-5 (TLR5) Deficient Mice Results in Metabolic Syndrome Gastroenterology. 138: S-52. DOI: 10.1016/S0016-5085(10)60237-5  0.336
2010 Hossain M, Gewirtz A, Roback J, Waller E. Flagellin-TLR5 Immune Response: A Novel Mechanism To Reduce GvHD In Allogeneic Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation. 16: S160. DOI: 10.1016/J.Bbmt.2009.12.027  0.303
2009 Onyeagocha C, Hossain MS, Kumar A, Jones RM, Roback J, Gewirtz AT. Latent cytomegalovirus infection exacerbates experimental colitis. The American Journal of Pathology. 175: 2034-42. PMID 19815702 DOI: 10.2353/Ajpath.2009.090471  0.375
2009 Scarlett UK, Cubillos-Ruiz JR, Nesbeth YC, Martinez DG, Engle X, Gewirtz AT, Ahonen CL, Conejo-Garcia JR. In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Research. 69: 7329-37. PMID 19738057 DOI: 10.1158/0008-5472.Can-09-0835  0.34
2009 Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. The Journal of Clinical Investigation. 119: 2231-44. PMID 19620771 DOI: 10.1172/Jci37716  0.357
2009 Fournier B, Williams IR, Gewirtz AT, Neish AS. Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection. Infection and Immunity. 77: 4121-9. PMID 19596770 DOI: 10.1128/Iai.00656-09  0.425
2009 Theiss AL, Vijay-Kumar M, Obertone TS, Jones DP, Hansen JM, Gewirtz AT, Merlin D, Sitaraman SV. Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology. 137: 199-208, 208.e1-6. PMID 19327358 DOI: 10.1053/J.Gastro.2009.03.033  0.362
2009 Vijay-Kumar M, Gewirtz AT. Flagellin: key target of mucosal innate immunity. Mucosal Immunology. 2: 197-205. PMID 19242410 DOI: 10.1038/Mi.2009.9  0.385
2009 Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Núñez G, Gewirtz AT. Induction of adaptive immunity by flagellin does not require robust activation of innate immunity European Journal of Immunology. 39: 359-371. PMID 19152336 DOI: 10.1002/Eji.200838804  0.364
2009 Deng J, Ma-Krupa W, Gewirtz AT, Younge BR, Goronzy JJ, Weyand CM. Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circulation Research. 104: 488-95. PMID 19150884 DOI: 10.1161/Circresaha.108.185777  0.346
2009 Vijay-Kumar M, Gewirtz AT. Role of flagellin in Crohn's disease: emblematic of the progress and enigmas in understanding inflammatory bowel disease. Inflammatory Bowel Diseases. 15: 789-95. PMID 19107795 DOI: 10.1002/Ibd.20734  0.369
2009 Tian J, Hao L, Chandra P, Jones DP, Willams IR, Gewirtz AT, Ziegler TR. Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G348-55. PMID 19095767 DOI: 10.1152/Ajpgi.90233.2008  0.345
2009 Garg P, Patel NR, Vijay-Kumar M, Ravi A, Merlin D, Gewirtz AT, Sitaraman SV. M2004 Deletion of Matrix Metalloproteinase-9 (MMP-9) Increases the Susceptibility for Colon Cancer Gastroenterology. 136: A-465. DOI: 10.1016/S0016-5085(09)62138-7  0.331
2009 Nguyen HTT, Dalmasso G, Yan Y, Powell K, Bhatt S, Kalman D, Gewirtz AT, Sitaraman SV, Merlin D. 556 Pathogenic Bacteria Transcriptionally Induce Colonic PepT1 Expression – An Implication in Modulating Bacterial-Epithelial Interaction Gastroenterology. 136: A-87. DOI: 10.1016/S0016-5085(09)60391-7  0.35
2009 Theiss AL, Vijay-Kumar M, Obertone TS, Jones D, Hansen J, Gewirtz AT, Merlin D, Sitaraman SV. 219 Prohibitin (PHB) Is a Novel Antioxidant That Attenuates Colonic Inflammation in Mice Gastroenterology. 136: A-41. DOI: 10.1016/S0016-5085(09)60190-6  0.345
2008 Vijay-Kumar M, Gewirtz AT. Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine. Gastroenterology. 135: 351-4. PMID 18619968 DOI: 10.1053/J.Gastro.2008.06.064  0.357
2008 Kolachala VL, Ruble BK, Vijay-Kumar M, Wang L, Mwangi S, Figler HE, Figler RA, Srinivasan S, Gewirtz AT, Linden J, Merlin D, Sitaraman SV. Blockade of adenosine A 2B receptors ameliorates murine colitis British Journal of Pharmacology. 155: 127-137. PMID 18536750 DOI: 10.1038/Bjp.2008.227  0.323
2008 Vijay-Kumar M, Aitken JD, Sanders CJ, Frias A, Sloane VM, Xu J, Neish AS, Rojas M, Gewirtz AT. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. Journal of Immunology (Baltimore, Md. : 1950). 180: 8280-5. PMID 18523294 DOI: 10.4049/Jimmunol.180.12.8280  0.771
2008 Sanders CJ, Moore DA, Williams IR, Gewirtz AT. Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. Journal of Immunology (Baltimore, Md. : 1950). 180: 7184-92. PMID 18490717 DOI: 10.4049/Jimmunol.180.11.7184  0.399
2008 Petrof EO, Musch MW, Ciancio M, Sun J, Hobert ME, Claud EC, Gewirtz A, Chang EB. Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G808-18. PMID 18202113 DOI: 10.1152/Ajpgi.00362.2007  0.367
2008 Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S, Gewirtz AT. Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease Infection and Immunity. 76: 1276-1281. PMID 18195036 DOI: 10.1128/Iai.01491-07  0.409
2008 Vijay-Kumar M, Aitken JD, Gewirtz AT. Toll like receptor-5: protecting the gut from enteric microbes. Seminars in Immunopathology. 30: 11-21. PMID 18066550 DOI: 10.1007/S00281-007-0100-5  0.416
2008 Ziegler TR, Luo M, Estívariz CF, Moore DA, Sitaraman SV, Hao L, Bazargan N, Klapproth JM, Tian J, Galloway JR, Leader LM, Jones DP, Gewirtz AT. Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R402-10. PMID 18003793 DOI: 10.1152/Ajpregu.00650.2007  0.301
2007 Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT. Deletion of TLR5 results in spontaneous colitis in mice. The Journal of Clinical Investigation. 117: 3909-21. PMID 18008007 DOI: 10.1172/Jci33084  0.434
2007 Kolachala VL, Bajaj R, Wang L, Yan Y, Ritzenthaler JD, Gewirtz AT, Roman J, Merlin D, Sitaraman SV. Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. The Journal of Biological Chemistry. 282: 32965-73. PMID 17855340 DOI: 10.1074/Jbc.M704388200  0.375
2007 Gewirtz AT, Sitaraman SV. In"sight" into immune blindness: Helicobacter pylori-induced gastritis requires T cells primed in the small intestine Peyer's patches. Gastroenterology. 133: 1044-5. PMID 17854610 DOI: 10.1053/J.Gastro.2007.07.044  0.364
2007 Garg P, Ravi A, Patel NR, Roman J, Gewirtz AT, Merlin D, Sitaraman SV. Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation. Gastroenterology. 132: 1877-89. PMID 17484881 DOI: 10.1053/J.Gastro.2007.02.048  0.345
2007 Charrier L, Yan Y, Nguyen HT, Dalmasso G, Laboisse CL, Gewirtz AT, Sitaraman SV, Merlin D. ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells. The Journal of Biological Chemistry. 282: 16948-58. PMID 17416588 DOI: 10.1074/Jbc.M700158200  0.328
2007 Vijay-Kumar M, Wu H, Aitken J, Kolachala VL, Neish AS, Sitaraman SV, Gewirtz AT. Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflammatory Bowel Diseases. 13: 856-64. PMID 17393379 DOI: 10.1002/Ibd.20142  0.349
2007 Gewirtz AT. TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant? American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G706-10. PMID 17038626 DOI: 10.1152/Ajpgi.00347.2006  0.34
2007 Garg P, Ravi A, Patel N, Roman J, Gewirtz A, Merlin D, Sitaraman S. Metalloproteinase-9 (MMP-9) regulates intestinal goblet cell specific gene expression Inflammatory Bowel Diseases. 13: 644. DOI: 10.1097/00054725-200705001-00007  0.308
2006 Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS. Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. The American Journal of Pathology. 169: 1686-700. PMID 17071592 DOI: 10.2353/Ajpath.2006.060345  0.438
2006 Xicohtencatl-Cortés J, Lyons S, Chaparro AP, Hernández DR, Saldaña Z, Ledesma MA, Rendón MA, Gewirtz AT, Klose KE, Girón JA. Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis. Molecular & Cellular Proteomics : McP. 5: 2374-83. PMID 16998199 DOI: 10.1074/Mcp.M600228-Mcp200  0.323
2006 Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozören N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Núñez G. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. The Journal of Biological Chemistry. 281: 35217-23. PMID 16984919 DOI: 10.1074/Jbc.M604933200  0.387
2006 Garg P, Rojas M, Ravi A, Bockbrader K, Epstein S, Vijay-Kumar M, Gewirtz AT, Merlin D, Sitaraman SV. Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 4103-12. PMID 16951375 DOI: 10.4049/Jimmunol.177.6.4103  0.312
2006 Sanders CJ, Yu Y, Moore DA, Williams IR, Gewirtz AT. Humoral immune response to flagellin requires T cells and activation of innate immunity. Journal of Immunology (Baltimore, Md. : 1950). 177: 2810-8. PMID 16920916 DOI: 10.4049/Jimmunol.177.5.2810  0.424
2006 Angers I, Sancho-Shimizu V, Descoteaux A, Gewirtz AT, Malo D. Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice Mammalian Genome. 17: 385-397. PMID 16688529 DOI: 10.1007/S00335-005-0132-X  0.36
2006 Yu Y, Nagai S, Wu H, Neish AS, Koyasu S, Gewirtz AT. TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. Journal of Immunology (Baltimore, Md. : 1950). 176: 6194-201. PMID 16670329 DOI: 10.4049/Jimmunol.176.10.6194  0.38
2006 Lu W, Hisatsune A, Koga T, Kato K, Kuwahara I, Lillehoj EP, Chen W, Cross AS, Gendler SJ, Gewirtz AT, Kim KC. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. Journal of Immunology (Baltimore, Md. : 1950). 176: 3890-4. PMID 16547220 DOI: 10.4049/Jimmunol.176.7.3890  0.387
2006 Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G1157-63. PMID 16439468 DOI: 10.1152/Ajpgi.00544.2005  0.34
2006 Gewirtz AT. Flag in the crossroads: flagellin modulates innate and adaptive immunity. Current Opinion in Gastroenterology. 22: 8-12. PMID 16319670 DOI: 10.1097/01.Mog.0000194791.59337.28  0.403
2006 Zeng H, Wu H, Sloane V, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G96-G108. PMID 16179598 DOI: 10.1152/Ajpgi.00273.2005  0.398
2006 Ma-Krupa W, Gršschel S, Piggott K, Vaglio A, Pryshchep O, Shimada K, Gewirtz A, Goronzy JJ, Weyand CM. 254 VASCULAR DENDRITIC CELLS IN GIANT CELL ARTERITIS: TRIGGERING OF VASCULAR INFLAMMATION BY TOLL-LIKE RECEPTOR LIGANDS. Journal of Investigative Medicine. 54: S301.4-S301. DOI: 10.2310/6650.2005.X0008.253  0.326
2005 Castaneda FE, Walia B, Vijay-Kumar M, Patel NR, Roser S, Kolachala VL, Rojas M, Wang L, Oprea G, Garg P, Gewirtz AT, Roman J, Merlin D, Sitaraman SV. Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology. 129: 1991-2008. PMID 16344067 DOI: 10.1053/J.Gastro.2005.09.017  0.331
2005 Babbin BA, Gewirtz AT. A most important annexation. The American Journal of Pathology. 166: 1581-3. PMID 15920143 DOI: 10.1016/S0002-9440(10)62468-6  0.331
2005 Vijay-Kumar M, Gentsch JR, Kaiser WJ, Borregaard N, Offermann MK, Neish AS, Gewirtz AT. Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. Journal of Immunology (Baltimore, Md. : 1950). 174: 6322-31. PMID 15879132 DOI: 10.4049/Jimmunol.174.10.6322  0.392
2005 Sitaraman SV, Klapproth JM, Moore DA, Landers C, Targan S, Williams IR, Gewirtz AT. Elevated flagellin-specific immunoglobulins in Crohn's disease. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G403-6. PMID 15388489 DOI: 10.1152/Ajpgi.00357.2004  0.352
2005 Walia B, Castaneda FE, Wang L, Kolachala VL, Bajaj R, Roman J, Merlin D, Gewirtz AT, Sitaraman SV. Polarized fibronectin secretion induced by adenosine regulates bacterial-epithelial interaction in human intestinal epithelial cells. The Biochemical Journal. 382: 589-96. PMID 15193149 DOI: 10.1042/Bj20040021  0.366
2004 Lyons S, Wang L, Casanova JE, Sitaraman SV, Merlin D, Gewirtz AT. Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. Journal of Cell Science. 117: 5771-80. PMID 15507487 DOI: 10.1242/Jcs.01500  0.413
2004 Yu Y, Zeng H, Vijay-Kumar M, Neish AS, Merlin D, Sitaraman SV, Gewirtz AT. STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression. The Journal of Biological Chemistry. 279: 35210-8. PMID 15199060 DOI: 10.1074/Jbc.M404064200  0.367
2004 Yu Y, Sitaraman S, Gewirtz AT. Intestinal epithelial cell regulation of mucosal inflammation. Immunologic Research. 29: 55-68. PMID 15181270 DOI: 10.1385/Ir:29:1-3:055  0.431
2004 Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proceedings of the National Academy of Sciences of the United States of America. 101: 7421-6. PMID 15123795 DOI: 10.1073/Pnas.0400832101  0.363
2004 Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons SL, Peek RM. Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. The Journal of Infectious Diseases. 189: 1914-20. PMID 15122529 DOI: 10.1086/386289  0.353
2004 Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. The Journal of Biological Chemistry. 279: 19902-7. PMID 14990585 DOI: 10.1074/Jbc.M311821200  0.394
2004 Sitaraman S, Liu X, Charrier L, Gu LH, Ziegler TR, Gewirtz A, Merlin D. Colonic leptin: source of a novel proinflammatory cytokine involved in IBD. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 696-8. PMID 14977884 DOI: 10.1096/Fj.03-0422Fje  0.388
2004 Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. 191 PANETH CELL CRYPTDINS ARE APICAL PARACRINE REGULATORS OF THE INNATE INTESTINAL INFLAMMATORY RESPONSE. Journal of Investigative Medicine. 52: S291.3-S291. DOI: 10.1136/Jim-52-Suppl1-744  0.392
2003 Buyse M, Charrier L, Sitaraman S, Gewirtz A, Merlin D. Interferon-gamma increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia. The American Journal of Pathology. 163: 1969-77. PMID 14578196 DOI: 10.1016/S0002-9440(10)63555-9  0.389
2003 Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. Journal of Immunology (Baltimore, Md. : 1950). 171: 3668-74. PMID 14500664 DOI: 10.4049/Jimmunol.171.7.3668  0.4
2003 Wang L, Walia B, Evans J, Gewirtz AT, Merlin D, Sitaraman SV. IL-6 induces NF-kappa B activation in the intestinal epithelia. Journal of Immunology (Baltimore, Md. : 1950). 171: 3194-201. PMID 12960348 DOI: 10.4049/Jimmunol.171.6.3194  0.333
2003 Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G282-90. PMID 12702497 DOI: 10.1016/S0016-5085(03)82441-1  0.369
2003 Langston HP, Ke Y, Gewirtz AT, Dombrowski KE, Kapp JA. Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. Journal of Immunology (Baltimore, Md. : 1950). 170: 2962-70. PMID 12626548 DOI: 10.4049/Jimmunol.170.6.2962  0.305
2003 Gewirtz AT. Intestinal epithelial toll-like receptors: to protect. And serve? Current Pharmaceutical Design. 9: 1-5. PMID 12570669 DOI: 10.2174/1381612033392422  0.411
2003 Kucharzik T, Gewirtz AT, Merlin D, Madara JL, Williams IR. Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium. American Journal of Physiology. Cell Physiology. 284: C888-96. PMID 12456400 DOI: 10.1152/Ajpcell.00507.2001  0.331
2003 Gewirtz A, Krishna U, Israel D, Yu Y, Peek RM. Helicobacter pylori evades toll-like receptor 5 innate immunity Gastroenterology. 124: A592. DOI: 10.1016/S0016-5085(03)82998-0  0.321
2003 Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Sitaraman SV, Gewirtz AT. STAT signaling underlies differences between flagellin-induced and TNF-induced epithelial gene expression Gastroenterology. 124: A106. DOI: 10.1016/S0016-5085(03)80523-1  0.347
2002 Gewirtz AT, Neish AS, Madara JL. Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins. Advances in Experimental Medicine and Biology. 507: 229-36. PMID 12664590 DOI: 10.1007/978-1-4615-0193-0_35  0.404
2002 Gewirtz AT, Liu Y, Sitaraman SV, Madara JL. Intestinal epithelial pathobiology: past, present and future. Best Practice & Research. Clinical Gastroenterology. 16: 851-67. PMID 12473295 DOI: 10.1053/Bega.2002.0339  0.383
2002 Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J, Sambhara S. Cutting edge: Impaired toll-like receptor expression and function in aging Journal of Immunology. 169: 4697-4701. PMID 12391175 DOI: 10.4049/Jimmunol.169.9.4697  0.377
2002 McSorley SJ, Ehst BD, Yu Y, Gewirtz AT. Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 169: 3914-9. PMID 12244190 DOI: 10.4049/Jimmunol.169.7.3914  0.345
2002 Gewirtz AT, Collier-Hyams LS, Young AN, Kucharzik T, Guilford WJ, Parkinson JF, Williams IR, Neish AS, Madara JL. Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. Journal of Immunology (Baltimore, Md. : 1950). 168: 5260-7. PMID 11994483 DOI: 10.4049/Jimmunol.168.10.5260  0.418
2002 Gewirtz AT, Reed KA, Merlin D, Hobert M, Neish AS, Madara JL. 21 Modeling microbial-epithelial interactions in the intestine Methods in Microbiology. 31: 377-396. DOI: 10.1016/S0580-9517(02)31022-5  0.326
2001 Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Journal of Immunology (Baltimore, Md. : 1950). 167: 1882-5. PMID 11489966 DOI: 10.4049/Jimmunol.167.4.1882  0.412
2001 Sitaraman SV, Merlin D, Wang L, Wong M, Gewirtz AT, Si-Tahar M, Madara JL. Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6. The Journal of Clinical Investigation. 107: 861-9. PMID 11285305 DOI: 10.1172/Jci11783  0.347
2001 Gewirtz AT, Madara JL. Periscope, up! Monitoring microbes in the intestine. Nature Immunology. 2: 288-90. PMID 11276197 DOI: 10.1038/86292  0.344
2001 Gewirtz AT, Simon PO, Schmitt CK, Taylor LJ, Hagedorn CH, O'Brien AD, Neish AS, Madara JL. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. The Journal of Clinical Investigation. 107: 99-109. PMID 11134185 DOI: 10.1172/Jci10501  0.353
2001 Sitaraman SV, Merlin D, Wang L, Wong M, Gewirtz AT, Si-Tahar M, Madara JL. Adenosine induces polarized secretion of interleukin-6 in intestinal epithelial cells: Bidirectional epithelial/neutrophil paracrine regulation in model crypt abscess Gastroenterology. 120: A184-A185. DOI: 10.1016/S0016-5085(08)80913-4  0.354
2000 Neish AS, Gewirtz AT, Zeng H, Young AN, Hobert ME, Karmali V, Rao AS, Madara JL. Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science (New York, N.Y.). 289: 1560-3. PMID 10968793 DOI: 10.1126/Science.289.5484.1560  0.342
2000 Gewirtz AT, Rao AS, Simon PO, Merlin D, Carnes D, Madara JL, Neish AS. Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway. The Journal of Clinical Investigation. 105: 79-92. PMID 10619864 DOI: 10.1172/Jci8066  0.359
2000 Gewirtz AT, Simon PO, Esterly D, Neish AS, Madara JL. S. typhimurium secretes a novel pro-inflammatory factor that is translocated across model intestinal epithelia Gastroenterology. 118: A101. DOI: 10.1016/S0016-5085(00)82482-8  0.306
1999 Gewirtz AT, Fokin VV, Petasis NA, Serhan CN, Madara JL. LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. The American Journal of Physiology. 276: C988-94. PMID 10199831 DOI: 10.1152/Ajpcell.1999.276.4.C988  0.353
1999 Gewirtz AT, Siber AM, Madara JL, McCormick BA. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infection and Immunity. 67: 608-17. PMID 9916066 DOI: 10.1128/Iai.67.2.608-617.1999  0.383
1998 Gewirtz AT, Seetoo KF, Simons ER. Neutrophil degranulation and phospholipase D activation are enhanced if the Na+/H+ antiport is blocked. Journal of Leukocyte Biology. 64: 98-103. PMID 9665282 DOI: 10.1002/Jlb.64.1.98  0.308
1998 Gewirtz AT, McCormick B, Neish AS, Petasis NA, Gronert K, Serhan CN, Madara JL. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. The Journal of Clinical Investigation. 101: 1860-9. PMID 9576749 DOI: 10.1172/Jci1339  0.42
1998 McCormick B, Gewirtz A, Madara JL. Epithelial crosstalk with bacteria and immune cells Current Opinion in Gastroenterology. 14: 492-497. DOI: 10.1097/00001574-199811000-00013  0.358
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