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Jinwei Zhang, BSc, MSc, PHD, PCAP, FHEA - Publications

Affiliations: 
2008-2011 School of Natural & Environmental Sciences Newcastle University, Newcastle upon Tyne, England, United Kingdom 
 2011-2017 MRC Phosphorylation & Ubiquitylation Unit (College of Life Science) University of Dundee, Dundee, Scotland, United Kingdom 
 2015-2016 School of Medicine Yale University School of Medicine, New Haven, CT 
 2017- Medical Schoool University of Exeter, UK 
 2019- Xiamen Cardiovascular Hospital Xiamen University School of Medicine 
 2023- Research Center of Chemical Kinomics Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 
Area:
Signalling Transduction, Biochemistry, Cell Biology, Biotechnology, Drug Discovery
Website:
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Jinwei_Zhang
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Year Citation  Score
2024 Qiu X, Liu R, Ling H, Zhou Y, Ren X, Zhou F, Zhang J, Huang W, Wang Z, Ding K. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. 269: 116310. PMID 38479166 DOI: 10.1016/j.ejmech.2024.116310  0.327
2024 Zhang J. Microbial stars: shedding light on gut microbes' role in insulin resistance and innovative diabetes therapies. Gut Microbes. 16: 2307581. PMID 38277136 DOI: 10.1080/19490976.2024.2307581  0.233
2024 Trinder A, Ding K, Zhang J. The Therapeutic Significance of HER3 in Non-small Cell Lung Cancer (NSCLC): A Review Study. Current Medicinal Chemistry. PMID 38231075 DOI: 10.2174/0109298673269305231115102542  0.281
2023 Zhang S, Meor Azlan NF, Josiah SS, Zhou J, Zhou X, Jie L, Zhang Y, Dai C, Liang D, Li P, Li Z, Wang Z, Wang Y, Ding K, Wang Y, ... Zhang J, et al. The role of family of cation-chloride cotransporters and drug discovery methodologies. Journal of Pharmaceutical Analysis. 13: 1471-1495. PMID 38223443 DOI: 10.1016/j.jpha.2023.09.002  0.794
2023 Pracucci E, Graham RT, Alberio L, Nardi G, Cozzolino O, Pillai V, Pasquini G, Saieva L, Walsh D, Landi S, Zhang J, Trevelyan AJ, Ratto GM. Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability. Nature Communications. 14: 7108. PMID 37925453 DOI: 10.1038/s41467-023-42711-7  0.369
2023 Zhang J. Hereditary causes of hypertension due to increased sodium transport. Current Opinion in Pediatrics. PMID 37909881 DOI: 10.1097/MOP.0000000000001304  0.371
2023 McMoneagle E, Zhou J, Zhang S, Huang W, Josiah SS, Ding K, Wang Y, Zhang J. Neuronal K-Cl cotransporter KCC2 as a promising drug target for epilepsy treatment. Acta Pharmacologica Sinica. PMID 37704745 DOI: 10.1038/s41401-023-01149-9  0.811
2023 Zhang J. Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer's disease treatment. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 37682322 DOI: 10.1007/s00011-023-01788-y  0.273
2023 Zhang J, Siew K, Sun D. Editorial: Targeting pumps, channels and transporters for the treatments of vascular, cardiovascular and kidney diseases. Frontiers in Pharmacology. 14: 1130882. PMID 36817130 DOI: 10.3389/fphar.2023.1130882  0.707
2023 Robert SM, Reeves BC, Kiziltug E, Duy PQ, Karimy JK, Mansuri MS, Marlier A, Allington G, Greenberg ABW, DeSpenza T, Singh AK, Zeng X, Mekbib KY, Kundishora AJ, Nelson-Williams C, ... ... Zhang J, et al. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell. 186: 764-785.e21. PMID 36803604 DOI: 10.1016/j.cell.2023.01.017  0.764
2023 Zhang J. A new mechanism of consciousness recovery from anesthesia regulated by K+-Cl– cotransporter KCC2 Brain‐X. 1: e19. DOI: https://doi.org/10.1002/brx2.19  0.345
2023 Zhang J. Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment Acta Pharmacologica Sinica. DOI: 10.1038/s41401-023-01149-9  0.364
2022 Josiah SS, Meor Azlan NF, Oguro-Ando A, Zhang J. Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting. Journal of Visualized Experiments : Jove. PMID 36571412 DOI: 10.3791/64179  0.803
2022 Bhuiyan MIH, Fischer S, Patel SM, Oft H, Zhang T, Foley LM, Zhang J, Hitchens TK, Molyneaux BJ, Deng X, Sun D. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. Neurochemistry International. 105441. PMID 36375633 DOI: 10.1016/j.neuint.2022.105441  0.598
2022 D'Silva E, Meor Azlan NF, Zhang J. Angiotensin II Receptor Blockers in the Management of Hypertension in Preventing Cognitive Impairment and Dementia-A Systematic Review. Pharmaceutics. 14. PMID 36297558 DOI: 10.3390/pharmaceutics14102123  0.744
2022 Chen L, Yu J, Wan L, Wu Z, Wang G, Hu Z, Ren L, Zhou J, Qian B, Zhao X, Zhang J, Liu X, Wang Y. Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus. Ibro Neuroscience Reports. 12: 355-365. PMID 35746976 DOI: 10.1016/j.ibneur.2022.04.010  0.365
2022 Zhang J, Yao J, Rong M. Editorial: Role of Ion Channels in Pain. Frontiers in Pharmacology. 13: 884665. PMID 35734416 DOI: 10.3389/fphar.2022.884665  0.252
2022 Küry S, Zhang J, Besnard T, Caro-Llopis A, Zeng X, Robert SM, Josiah SS, Kiziltug E, Denommé-Pichon AS, Cogné B, Kundishora AJ, Hao LT, Li H, Stevenson RE, Louie RJ, et al. Rare pathogenic variants in WNK3 cause X-linked intellectual disability. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35678782 DOI: 10.1016/j.gim.2022.05.009  0.793
2022 Zhong C, Zhao H, Xie X, Qi Z, Li Y, Jia L, Zhang J, Lu Y. Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. Frontiers in Physiology. 13: 815301. PMID 35418879 DOI: 10.3389/fphys.2022.815301  0.334
2022 Wang J, Liu R, Hasan MN, Fischer S, Chen Y, Como M, Fiesler VM, Bhuiyan MIH, Dong S, Li E, Kahle KT, Zhang J, Deng X, Subramanya AR, Begum G, et al. Role of SPAK-NKCC1 signaling cascade in the choroid plexus blood-CSF barrier damage after stroke. Journal of Neuroinflammation. 19: 91. PMID 35413993 DOI: 10.1186/s12974-022-02456-4  0.729
2022 Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, et al. NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice Stroke. STROKEAHA121038351. PMID 35272484 DOI: 10.1161/STROKEAHA.121.038351  0.302
2022 Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, et al. NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice. Stroke. STROKEAHA121038351. PMID 35272484 DOI: 10.1161/STROKEAHA.121.038351  0.779
2022 Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning C, Sorrell FJ, D'Angiolella V, Fischer R, Mulder M, Gamba G, Alessi DR, Bullock AN. Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. The Biochemical Journal. PMID 35179207 DOI: 10.1042/BCJ20220019  0.702
2021 Salihu S, Meor Azlan NF, Josiah SS, Wu Z, Wang Y, Zhang J. Role of the cation-chloride-cotransporters in the circadian system. Asian Journal of Pharmaceutical Sciences. 16: 589-597. PMID 34849164 DOI: 10.1016/j.ajps.2020.10.003  0.707
2021 Belaïdouni Y, Diabira D, Zhang J, Graziano JC, Bader F, Montheil A, Menuet C, Wayman GA, Gaiarsa JL. The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mice. Frontiers in Cellular Neuroscience. 15: 724976. PMID 34602980 DOI: 10.3389/fncel.2021.724976  0.36
2021 Jonniya NA, Zhang J, Kar P. Molecular Mechanism of Inhibiting WNK Binding to OSR1 by Targeting the Allosteric Pocket of the OSR1-CCT Domain with Potential Antihypertensive Inhibitors: An Study. The Journal of Physical Chemistry. B. 125: 9115-9129. PMID 34369793 DOI: 10.1021/acs.jpcb.1c04672  0.332
2021 Zhang J, Zeng R, Labes A. Editorial: Marine Microbial-Derived Molecules and Their Potential Medical and Cosmetic Applications. Frontiers in Microbiology. 12: 706152. PMID 34335540 DOI: 10.3389/fmicb.2021.706152  0.194
2021 Zhang J, Zeng R and Labes A.. Editorial: Marine microbial-derived molecules and their potential medical and cosmetic applications Frontiers in Microbiology. 12: 706152. PMID 34335540 DOI: 10.3389/fmicb.2021.706152  0.194
2021 Meor Azlan NF, Koeners MP, Zhang J.. egulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension Acta Pharmaceutica Sinica B. 11: 1117-1128. PMID 34094823 DOI: 10.1016/j.apsb.2020.09.009  0.376
2021 Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukova O, Argaiz ER, Lerdo de Tejada F, Murillo-de-Ozores AR, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castaneda-Bueno M, Alessi DR, Gamba G. Role of KLHL3 and dietary K in regulating KS-WNK1 expression. American Journal of Physiology. Renal Physiology. PMID 33682442 DOI: 10.1152/ajprenal.00575.2020  0.597
2021 Josiah SS, Meor Azlan NF, Zhang J. Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke. International Journal of Molecular Sciences. 22. PMID 33513812 DOI: 10.3390/ijms22031232  0.783
2021 Brown A, Meor Azlan NF, Wu Z, Zhang J. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension Acta Pharmacologica Sinica. 42: 508-517. PMID 32724175 DOI: 10.1038/s41401-020-0474-7  0.37
2021 Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukova O, Argaiz ER, Lerdo de Tejada F, Murillo-de-Ozores AR, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castaneda-Bueno M, Alessi RA, and Gamba G. Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression American Journal of Physiology-Renal Physiology. 320: F734-F747.. DOI: 10.1152/ajprenal.00575.2020  0.331
2020 Andrews K, Josiah SS, Zhang J. The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington's Disease and Its Comorbidities. International Journal of Molecular Sciences. 21. PMID 33266310 DOI: 10.3390/ijms21239142  0.811
2020 Meor Azlan NF, Zhang J. Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells. 9. PMID 33066544 DOI: 10.3390/cells9102293  0.8
2020 Delmotte Q, Hamze M, Medina I, Buhler E, Zhang J, Belgacem YH, Porcher C. Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex. Journal of Cell Science. PMID 32989040 DOI: 10.1242/jcs.247700  0.396
2020 Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT. New drugs on the horizon for cerebral edema: what's in the clinical development pipeline? Expert Opinion On Investigational Drugs. PMID 32815401 DOI: 10.1080/13543784.2020.1813715  0.748
2020 Brown A, Meor Azlan NF, Wu Z, Zhang J. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Acta Pharmacologica Sinica. PMID 32724175 DOI: 10.1038/s41401-020-0474-7  0.789
2020 Zhang J, Cordshagen A, Medina I, Nothwang HG, Wisniewski JR, Winklhofer M, Hartmann AM. Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. Plos One. 15: e0232967. PMID 32413057 DOI: 10.1371/Journal.Pone.0232967  0.533
2020 Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, et al. Modulation of brain cation-Cl cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications. 11: 78. PMID 31911626 DOI: 10.1038/S41467-019-13851-6  0.807
2019 Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signaling. 12. PMID 31615901 DOI: 10.1126/Scisignal.Aaw9315  0.816
2019 Pisella LI, Gaiarsa JL, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signaling. 12. PMID 31615899 DOI: 10.1126/Scisignal.Aay0300  0.613
2019 Tillman L, Zhang J. Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K-Cl Cotransporter KCC2. Biomed Research International. 2019: 8941046. PMID 31240228 DOI: 10.1155/2019/8941046  0.792
2019 Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z. The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease. 10: 626-636. PMID 31165006 DOI: 10.14336/Ad.2018.0928  0.74
2018 Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, ... ... Zhang J, et al. Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron. PMID 30578106 DOI: 10.1016/J.Neuron.2018.11.041  0.761
2018 Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa JL. The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. Elife. 7. PMID 30106375 DOI: 10.7554/Elife.36726  0.469
2018 Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, ... ... Zhang J, et al. Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. Acs Chemical Biology. PMID 30102854 DOI: 10.2210/Pdb6Cd5/Pdb  0.798
2018 Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa J. Author response: The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice Elife. DOI: 10.7554/Elife.36726.021  0.345
2018 Bhuiyan MIH, Huang H, Zhang T, Molyneaux BJ, Poloyac SM, Zhang J, Deng X, Sun D, Sun D. Abstract P198: WNK-SPAK-NKCC1 Cascade Activation Contributes to Worsened Brain Damage in Mice With Hypertension Co-Morbidity after Ischemic Stroke Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P198  0.643
2017 Zhang J, Burgess JG. Enhanced eicosapentaenoic acid production by a new deep-sea marine bacterium Shewanella electrodiphila MAR441T. Plos One. 12: e0188081. PMID 29176835 DOI: 10.1371/Journal.Pone.0188081  0.325
2017 Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nature Communications. 8: 1776. PMID 29176664 DOI: 10.1038/S41467-017-01749-0  0.674
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine. PMID 28692063 DOI: 10.1038/Nm.4361  0.758
2017 Zhang J, Karimy JK, Delpire E, Kahle KT. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opinion On Therapeutic Targets. PMID 28679296 DOI: 10.1080/14728222.2017.1351949  0.692
2017 Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metabolism. 25: 285-299. PMID 28178566 DOI: 10.1016/J.Cmet.2017.01.007  0.675
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Furey CG, Gerzanich V, Simard JM, Kahle KT. 166 TLR-4-Regulated Cerebrospinal Fluid Hypersecretion in Post-Hemorrhagic Hydrocephalus Neurosurgery. 64: 242-242. DOI: 10.1093/Neuros/Nyx417.166  0.598
2016 Zhang J, Deng X, Kahle KT. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Science Signaling. 9: pe3. PMID 27811182 DOI: 10.1126/Scisignal.Aaj2227  0.734
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/Srep35986  0.825
2016 Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Science Signaling. 9: ra77. PMID 27485015 DOI: 10.1126/Scisignal.Aae0546  0.717
2016 Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, et al. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Science Signaling. 9: ra32. PMID 27025876 DOI: 10.1126/Scisignal.Aad0163  0.626
2016 Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E. MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas. Frontiers in Microbiology. 7: 104. PMID 26903983 DOI: 10.3389/Fmicb.2016.00104  0.316
2016 Andrukhova O, Zhang J, Alessi D, Erben R. Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance Bone Abstracts. DOI: 10.1530/Boneabs.5.Op30  0.339
2015 Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. Embo Molecular Medicine. 7: 1285-306. PMID 26286618 DOI: 10.15252/emmm.201505444  0.735
2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling. 8: ra65. PMID 26126716 DOI: 10.1126/Scisignal.Aaa0354  0.69
2015 Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, et al. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. Embo Reports. PMID 26116755 DOI: 10.15252/Embr.201540352  0.631
2015 Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 6: 584-9. PMID 26005538 DOI: 10.1021/Acsmedchemlett.5B00064  0.801
2015 Zhang J, Burgess JG. Shewanella electrodiphila sp. nov., a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. International Journal of Systematic and Evolutionary Microbiology. 65: 2882-9. PMID 25999594 DOI: 10.1099/Ijs.0.000345  0.307
2015 Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Human Molecular Genetics. 24: 4545-58. PMID 25994507 DOI: 10.1093/hmg/ddv185  0.783
2014 Zhang J, Burgess JG. Shewanella dovemarinesis sp. nov., a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments. International Journal of Systematic and Evolutionary Microbiology. PMID 25056297 DOI: 10.1099/Ijs.0.057125-0  0.31
2014 Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Science Signaling. 7: re3. PMID 25028718 DOI: 10.1126/Scisignal.2005365  0.771
2014 de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. The Biochemical Journal. 458: 559-73. PMID 24393035 DOI: 10.1042/Bj20131478  0.762
2014 Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity Neurosurgery. 61: 214. DOI: 10.1227/01.Neu.0000452440.75411.82  0.744
2013 Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. European Journal of Medicinal Chemistry. 70: 758-67. PMID 24239623 DOI: 10.1016/J.Ejmech.2013.10.052  0.78
2013 Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis. 76: 49-58. PMID 23313773 DOI: 10.1016/J.Jpba.2012.12.002  0.639
2013 Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics. 22: 328-44. PMID 23065705 DOI: 10.1093/Hmg/Dds431  0.654
2012 Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Brain Penetrant LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 3: 658-662. PMID 23066449 DOI: 10.1021/Ml300123A  0.799
2012 Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, Gray NS. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 5625-9. PMID 22863203 DOI: 10.1016/J.Bmcl.2012.06.104  0.772
2012 Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. Plos One. 7: e39132. PMID 22723946 DOI: 10.1371/Journal.Pone.0039132  0.747
2012 Zhang J, Zhang E, Scott K, Burgess JG. Enhanced electricity production by use of reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science & Technology. 46: 2984-92. PMID 22352455 DOI: 10.1021/Es2020007  0.308
2012 Zhang J, Deng X, Choi HG, Alessi DR, Gray NS. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 1864-9. PMID 22335897 DOI: 10.1016/J.Bmcl.2012.01.084  0.775
2012 Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, et al. Discovery of potent and selective covalent inhibitors of JNK. Chemistry & Biology. 19: 140-54. PMID 22284361 DOI: 10.1016/J.Chembiol.2011.11.010  0.708
2011 Zhang J, Zeng R. Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193 World Journal of Microbiology and Biotechnology. 27: 841-850. DOI: 10.1007/S11274-010-0526-0  0.332
2008 Zhang J, Zeng R. Molecular cloning and expression of a cold-adapted lipase gene from an Antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323. Marine Biotechnology. 10: 612-621. PMID 18461394 DOI: 10.1007/S10126-008-9099-4  0.33
2008 Zhang J, Zeng R. Purification and Characterization of a Cold-Adapted α-Amylase Produced by Nocardiopsis sp. 7326 Isolated from Prydz Bay, Antarctic Marine Biotechnology. 10: 75-82. PMID 17934774 DOI: 10.1007/S10126-007-9035-Z  0.349
2007 Zhang J, Lin S, Zeng R. Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychrotrophic bacterium, Psychrobacter sp 7195. Journal of Microbiology and Biotechnology. 17: 604-10. PMID 18051271  0.25
2006 Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nature Genetics. 38: 1124-32. PMID 16964266 DOI: 10.1038/Ng1877  0.655
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