| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2024 | Jiang L, Roberts R, Wong M, Zhang L, Webber CJ, Libera J, Wang Z, Kilci A, Jenkins M, Ortiz AR, Dorrian L, Sun J, Sun G, Rashad S, Kornbrek C, ... ... Saido TC, et al. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APP/MAPT mouse model of Alzheimer's disease. Frontiers in Neuroscience. 18: 1372297. PMID 38572146 DOI: 10.3389/fnins.2024.1372297 | 0.35 | |||
| 2024 | Wang T, Sobue A, Watanabe S, Komine O, Saido TC, Saito T, Yamanaka K. Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease. Journal of Neuroinflammation. 21: 55. PMID 38383481 DOI: 10.1186/s12974-024-03046-2 | 0.324 | |||
| 2024 | Huang HX, Inglese P, Tang J, Yagoubi R, Correia GDS, Horneffer-van der Sluis VM, Camuzeaux S, Wu V, Kopanitsa MV, Willumsen N, Jackson JS, Barron AM, Saito T, Saido TC, Gentlemen S, et al. Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains. Journal of Neurochemistry. PMID 38372586 DOI: 10.1111/jnc.16042 | 0.336 | |||
| 2024 | Srinivasan S, Kancheva D, De Ren S, Saito T, Jans M, Boone F, Vandendriessche C, Paesmans I, Maurin H, Vandenbroucke RE, Hoste E, Voet S, Scheyltjens I, Pavie B, Lippens S, ... ... Saido T, et al. Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease. Frontiers in Immunology. 15: 1323409. PMID 38352874 DOI: 10.3389/fimmu.2024.1323409 | 0.391 | |||
| 2024 | Morrissey ZD, Gao J, Shetti A, Li W, Zhan L, Li W, Fortel I, Saido T, Saito T, Ajilore O, Cologna SM, Lazarov O, Leow AD. Temporal alterations in white matter in an knock-in mouse model of Alzheimer's disease. Eneuro. PMID 38290851 DOI: 10.1523/ENEURO.0496-23.2024 | 0.321 | |||
| 2023 | Daniels MJD, Lefevre L, Szymkowiak S, Drake A, McCulloch L, Tzioras M, Barrington J, Dando OR, He X, Mohammad M, Sasaguri H, Saito T, Saido TC, Spires-Jones T, McColl B. Cystatin F () drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease. Elife. 12. PMID 38085657 DOI: 10.7554/eLife.85279 | 0.341 | |||
| 2023 | Benskey MJ, Panoushek S, Saito T, Saido TC, Grabinski T, Kanaan NM. Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse. Frontiers in Aging Neuroscience. 15: 1265151. PMID 37842124 DOI: 10.3389/fnagi.2023.1265151 | 0.319 | |||
| 2023 | Izuo N, Watanabe N, Noda Y, Saito T, Saido TC, Yokote K, Hotta H, Shimizu T. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging Cell. 22: e13994. PMID 37822109 DOI: 10.1111/acel.13994 | 0.319 | |||
| 2023 | Ito S, Yagi R, Ogata S, Masuda T, Saito T, Saido T, Ohtsuki S. Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease. Fluids and Barriers of the Cns. 20: 66. PMID 37705104 DOI: 10.1186/s12987-023-00466-9 | 0.369 | |||
| 2023 | Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, et al. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science Translational Medicine. 15: eabo6889. PMID 37703352 DOI: 10.1126/scitranslmed.abo6889 | 0.327 | |||
| 2023 | Trojan E, Curzytek K, Cieślik P, Wierońska JM, Graff J, Lasoń W, Saito T, Saido TC, Basta-Kaim A. Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APP mouse model of Alzheimer's disease. Neurobiology of Disease. 184: 106219. PMID 37422091 DOI: 10.1016/j.nbd.2023.106219 | 0.317 | |||
| 2023 | Jiang L, Roberts R, Wong M, Zhang L, Webber CJ, Kilci A, Jenkins M, Sun J, Sun G, Rashad S, Dedon PC, Daley SA, Xia W, Ortiz AR, Dorrian L, ... ... Saido TC, et al. Accumulation of m6A exhibits stronger correlation with MAPT than β-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer's disease. Research Square. PMID 37292629 DOI: 10.21203/rs.3.rs-2745852/v1 | 0.387 | |||
| 2023 | Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, ... ... Saido T, et al. Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature. PMID 37258678 DOI: 10.1038/s41586-023-06120-6 | 0.301 | |||
| 2023 | Carús-Cadavieco M, Berenguer López I, Montoro Canelo A, Serrano-Lope MA, González-de la Fuente S, Aguado B, Fernández-Rodrigo A, Saido TC, Frank García A, Venero C, Esteban JA, Guix F, Dotti CG. Cognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type. Life Science Alliance. 6. PMID 37059474 DOI: 10.26508/lsa.202201789 | 0.308 | |||
| 2023 | Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, et al. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. Iscience. 26: 106375. PMID 37035000 DOI: 10.1016/j.isci.2023.106375 | 0.351 | |||
| 2023 | Jiang L, Roberts R, Wong M, Zhang L, Webber CJ, Kilci A, Jenkins M, Sun G, Rashad S, Sun J, Dedon PC, Daley SA, Xia W, Ortiz AR, Dorrian L, ... ... Saido TC, et al. Accumulation of m A exhibits stronger correlation with MAPT than β-amyloid pathology in an APP /MAPT mouse model of Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 37034774 DOI: 10.1101/2023.03.28.534515 | 0.384 | |||
| 2023 | Sato W, Watanabe-Takahashi M, Murata T, Utsunomiya-Tate N, Motoyama J, Anzai M, Ishihara S, Nishioka N, Uchiyama H, Togashi J, Nishihara S, Kawasaki K, Saito T, Saido TC, Funamoto S, et al. A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation. Communications Biology. 6: 383. PMID 37031306 DOI: 10.1038/s42003-023-04771-9 | 0.332 | |||
| 2023 | Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, et al. Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide. Embo Molecular Medicine. e17052. PMID 36994913 DOI: 10.15252/emmm.202217052 | 0.338 | |||
| 2023 | Andersson E, Schultz N, Saito T, Saido TC, Blennow K, Gouras GK, Zetterberg H, Hansson O. Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App knock-in mouse model of Alzheimer's disease. Alzheimer's Research & Therapy. 15: 64. PMID 36964585 DOI: 10.1186/s13195-023-01196-8 | 0.327 | |||
| 2023 | Kaneko R, Matsui A, Watanabe M, Harada Y, Kanamori M, Awata N, Kawazoe M, Takao T, Kobayashi Y, Kikutake C, Suyama M, Saito T, Saido TC, Ito M. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflammation and Regeneration. 43: 20. PMID 36922861 DOI: 10.1186/s41232-023-00257-7 | 0.359 | |||
| 2023 | Yoshimura R, Miyasaka T, Funamoto S, Saito T, Saido TC, Ikegawa M, Kakuda N. The senile plaque: Morphological differences in APP knock-in mice brains by fixatives. Brain and Behavior. 13: e2953. PMID 36879381 DOI: 10.1002/brb3.2953 | 0.382 | |||
| 2023 | Park H, Cho B, Kim H, Saito T, Saido TC, Won KJ, Kim J. Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature Communications. 14: 802. PMID 36781874 DOI: 10.1038/s41467-023-36519-8 | 0.36 | |||
| 2023 | Hashimoto S, Matsuba Y, Takahashi M, Kamano N, Watamura N, Sasaguri H, Takado Y, Yoshihara Y, Saito T, Saido TC. Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation. Scientific Reports. 13: 1109. PMID 36670138 DOI: 10.1038/s41598-023-27653-w | 0.332 | |||
| 2022 | Honda K, Saito Y, Saito H, Toyoda M, Abe R, Saito T, Saido TC, Michikawa M, Taru H, Sobu Y, Hata S, Nakaya T, Suzuki T. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of Aging. 123: 63-74. PMID 36638682 DOI: 10.1016/j.neurobiolaging.2022.12.003 | 0.381 | |||
| 2022 | Huang Y, Rafael Guimarães T, Todd N, Ferguson C, Weiss KM, Stauffer FR, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A. G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204828119. PMID 36161942 DOI: 10.1073/pnas.2204828119 | 0.325 | |||
| 2022 | Yoshimatsu S, Seki F, Okahara J, Watanabe H, Sasaguri H, Haga Y, Hata JI, Sanosaka T, Inoue T, Mineshige T, Lee CY, Shinohara H, Kurotaki Y, Komaki Y, Kishi N, ... ... Saido TC, et al. Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Neuroscience Research. PMID 36075457 DOI: 10.1016/j.neures.2022.08.008 | 0.362 | |||
| 2022 | Inoue M, Higashi T, Hayashi Y, Onodera R, Fujisawa K, Taharabaru T, Yokoyama R, Ouchi K, Misumi Y, Ueda M, Inoue Y, Mizuguchi M, Saito T, Saido TC, Ando Y, et al. Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis. Acs Applied Materials & Interfaces. PMID 36052562 DOI: 10.1021/acsami.2c09913 | 0.316 | |||
| 2022 | Wang S, Ichinomiya T, Savchenko P, Devulapalli S, Wang D, Beltz G, Saito T, Saido TC, Wagner SL, Patel HH, Head BP. Age-Dependent Behavioral and Metabolic Assessment of Knock-in (KI) Mice. Frontiers in Molecular Neuroscience. 15: 909989. PMID 35966019 DOI: 10.3389/fnmol.2022.909989 | 0.336 | |||
| 2022 | Blume T, Filser S, Sgobio C, Peters F, Neumann U, Shimshek D, Saito T, Saido TC, Brendel M, Herms J. β-secretase inhibition prevents structural spine plasticity deficits in mice. Frontiers in Aging Neuroscience. 14: 909586. PMID 35936777 DOI: 10.3389/fnagi.2022.909586 | 0.34 | |||
| 2022 | Ye Q, Gast G, Su X, Saito T, Saido TC, Holmes TC, Xu X. Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiology of Disease. 172: 105820. PMID 35843448 DOI: 10.1016/j.nbd.2022.105820 | 0.301 | |||
| 2022 | Ishii A, Matsuba Y, Mihira N, Kamano N, Saito T, Muramatsu SI, Yokosuka M, Saido TC, Hashimoto S. Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain. Journal of Biochemistry. PMID 35818334 DOI: 10.1093/jb/mvac058 | 0.383 | |||
| 2022 | Carpanini SM, Torvell M, Bevan RJ, Byrne RAJ, Daskoulidou N, Saito T, Saido TC, Taylor PR, Hughes TR, Zelek WM, Morgan BP. Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models. Acta Neuropathologica Communications. 10: 99. PMID 35794654 DOI: 10.1186/s40478-022-01404-w | 0.316 | |||
| 2022 | Jiang R, Smailovic U, Haytural H, Tijms BM, Li H, Haret RM, Shevchenko G, Chen G, Abelein A, Gobom J, Frykman S, Sekiguchi M, Fujioka R, Watamura N, Sasaguri H, ... ... Saido TC, et al. Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis. Acta Neuropathologica Communications. 10: 96. PMID 35787306 DOI: 10.1186/s40478-022-01398-5 | 0.383 | |||
| 2022 | Gannon M, Wang B, Stringfellow SA, Quintin S, Mendoza I, Srikantha T, Roberts AC, Saito T, Saido TC, Roberson E, Yacoubian TA. 14-3-3θ does not protect against behavioral or pathological deficits in Alzheimer's disease mouse models. Eneuro. PMID 35697511 DOI: 10.1523/ENEURO.0368-21.2022 | 0.389 | |||
| 2022 | Watamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Mihira N, Fujioka R, Nagata K, Hashimoto S, Saito T, Ohshima T, Saido TC, Sasaguri H. An isogenic panel of knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities. Science Advances. 8: eabm6155. PMID 35675411 DOI: 10.1126/sciadv.abm6155 | 0.34 | |||
| 2022 | Watamura N, Sato K, Saido TC. Mouse models of Alzheimer's disease for preclinical research. Neurochemistry International. 158: 105361. PMID 35618239 DOI: 10.1016/j.neuint.2022.105361 | 0.343 | |||
| 2022 | Wang W, Tanokashira D, Shibayama Y, Tsuji R, Maruyama M, Kuroiwa C, Saito T, Saido TC, Taguchi A. Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKI mice. Neuropsychopharmacology Reports. PMID 35582933 DOI: 10.1002/npr2.12257 | 0.31 | |||
| 2022 | Kobayashi Y, Kohbuchi S, Koganezawa N, Sekino Y, Shirao T, Saido TC, Saito T, Saito Y. Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease. Biochemical and Biophysical Research Communications. 610: 85-91. PMID 35453040 DOI: 10.1016/j.bbrc.2022.04.050 | 0.377 | |||
| 2022 | Hoshi K, Kanno M, Abe M, Murakami T, Ugawa Y, Goto A, Honda T, Saito T, Saido TC, Yamaguchi Y, Miyajima M, Furukawa K, Arai H, Hashimoto Y. High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease. Metabolites. 12. PMID 35448543 DOI: 10.3390/metabo12040355 | 0.306 | |||
| 2022 | Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nilsson P, Winblad B, ... ... Saido TC, et al. Recent Advances in the Modeling of Alzheimer's Disease. Frontiers in Neuroscience. 16: 807473. PMID 35431779 DOI: 10.3389/fnins.2022.807473 | 0.403 | |||
| 2022 | Niikura R, Miyazaki T, Takase K, Sasaguri H, Saito T, Saido TC, Goto T. Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App mice. Molecular Brain. 15: 32. PMID 35387663 DOI: 10.1186/s13041-022-00910-1 | 0.358 | |||
| 2022 | Tachida Y, Miura S, Muto Y, Takuwa H, Sahara N, Shindo A, Matsuba Y, Saito T, Taniguchi N, Kawaguchi Y, Tomimoto H, Saido T, Kitazume S. Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice. The Journal of Biological Chemistry. 101880. PMID 35367207 DOI: 10.1016/j.jbc.2022.101880 | 0.379 | |||
| 2022 | Islam A, Saito T, Saido T, Ali AB. Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease. Seminars in Cell & Developmental Biology. PMID 35292192 DOI: 10.1016/j.semcdb.2022.03.001 | 0.347 | |||
| 2022 | Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. Iscience. 25: 103869. PMID 35243232 DOI: 10.1016/j.isci.2022.103869 | 0.305 | |||
| 2022 | Hao X, Li Z, Li W, Katz J, Michalek SM, Barnum SR, Pozzo-Miller L, Saito T, Saido TC, Wang Q, Roberson ED, Zhang P. Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice. Frontiers in Immunology. 13: 816640. PMID 35178049 DOI: 10.3389/fimmu.2022.816640 | 0.352 | |||
| 2022 | McKee CA, Lee J, Cai Y, Saito T, Saido T, Musiek ES. Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden. Scientific Reports. 12: 1796. PMID 35110643 DOI: 10.1038/s41598-022-05862-z | 0.384 | |||
| 2022 | Kamei N, Hashimoto A, Tanaka E, Murata K, Yamaguchi M, Yokoyama N, Kato M, Oki K, Saito T, Saido TC, Takeda-Morishita M. Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model. Drug Delivery and Translational Research. PMID 35015254 DOI: 10.1007/s13346-022-01117-6 | 0.326 | |||
| 2021 | Mizuno Y, Abolhassani N, Mazzei G, Sakumi K, Saito T, Saido TC, Ninomiya T, Iwaki T, Yamasaki R, Kira JI, Nakabeppu Y. MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2021: 8635088. PMID 34970419 DOI: 10.1155/2021/8635088 | 0.387 | |||
| 2021 | Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido TC, Yamasaki R, Kira JI, Nakabeppu Y. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior. Neuroscience Research. PMID 34838904 DOI: 10.1016/j.neures.2021.11.009 | 0.375 | |||
| 2021 | Liu X, Zhou Q, Zhang JH, Wang KY, Saito T, Saido TC, Wang X, Gao X, Azuma K. Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin. Cells. 10. PMID 34831483 DOI: 10.3390/cells10113261 | 0.373 | |||
| 2021 | Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido TC, Evers BM, White CL, Connor J, Hammer RE, Herz J. NHE6-depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Elife. 10. PMID 34617884 DOI: 10.7554/eLife.72034 | 0.366 | |||
| 2021 | Bettegazzi B, Sebastian Monasor L, Bellani S, Codazzi F, Restelli LM, Colombo AV, Deigendesch N, Frank S, Saito T, Saido TC, Lammich S, Tahirovic S, Grohovaz F, Zacchetti D. Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease. Cell Death & Disease. 12: 769. PMID 34349120 DOI: 10.1038/s41419-021-04062-3 | 0.364 | |||
| 2021 | Sato K, Watamura N, Fujioka R, Mihira N, Sekiguchi M, Nagata K, Ohshima T, Saito T, Saido TC, Sasaguri H. A 3 generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide. The Journal of Biological Chemistry. 101004. PMID 34329683 DOI: 10.1016/j.jbc.2021.101004 | 0.368 | |||
| 2021 | Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, Wong N, Stringer KM, Vitanova KS, Smith VC, Joshi D, Saito T, Saido TC, Hardy J, Hanrieder J, et al. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular Neurodegeneration. 16: 47. PMID 34266459 DOI: 10.1186/s13024-021-00457-0 | 0.383 | |||
| 2021 | Mazzei G, Ikegami R, Abolhassani N, Haruyama N, Sakumi K, Saito T, Saido TC, Nakabeppu Y. A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App knock-in mouse model. Aging Cell. e13429. PMID 34245097 DOI: 10.1111/acel.13429 | 0.36 | |||
| 2021 | Sharoar MG, Palko S, Ge Y, Saido TC, Yan R. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains. Molecular Neurodegeneration. 16: 45. PMID 34215298 DOI: 10.1186/s13024-021-00464-1 | 0.377 | |||
| 2021 | Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, Saito T, Saido TC, Sekiya M, Iijima KM. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. Journal of Alzheimer's Disease : Jad. PMID 34180416 DOI: 10.3233/JAD-210385 | 0.314 | |||
| 2021 | Meier SR, Sehlin D, Roshanbin S, Lim Falk V, Saito T, Saido TC, Neumann U, Rokka J, Eriksson J, Syvanen S. C-PIB and I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 34088777 DOI: 10.2967/jnumed.121.262083 | 0.336 | |||
| 2021 | Takamura R, Mizuta K, Sekine Y, Islam T, Saito T, Sato M, Ohkura M, Nakai J, Ohshima T, Saido TC, Hayashi Y. Modality specific impairment of hippocampal CA1 neurons of Alzheimer's disease model mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33980545 DOI: 10.1523/JNEUROSCI.0208-21.2021 | 0.35 | |||
| 2021 | Nakamura Y, Yamamoto T, Xu X, Kobayashi S, Tanaka S, Tamitani M, Saito T, Saido TC, Yano M. Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease. Scientific Reports. 11: 7289. PMID 33790404 DOI: 10.1038/s41598-021-86822-x | 0.323 | |||
| 2021 | Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9 | 0.353 | |||
| 2021 | Taslima F, Jung CG, Zhou C, Abdelhamid M, Abdullah M, Goto T, Saito T, Saido TC, Michikawa M. Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33720883 DOI: 10.3233/JAD-201055 | 0.305 | |||
| 2021 | Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, ... Saido TC, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011 | 0.356 | |||
| 2021 | Kundu P, Torres ERS, Stagaman K, Kasschau K, Okhovat M, Holden S, Ward S, Nevonen KA, Davis BA, Saito T, Saido TC, Carbone L, Sharpton TJ, Raber J. Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in App, App, and wild type mice. Scientific Reports. 11: 4678. PMID 33633159 DOI: 10.1038/s41598-021-83851-4 | 0.308 | |||
| 2021 | Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. Journal of Alzheimer's Disease : Jad. PMID 33492290 DOI: 10.3233/JAD-201174 | 0.348 | |||
| 2021 | Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathologica Communications. 9: 1. PMID 33402227 DOI: 10.1186/s40478-020-01099-x | 0.32 | |||
| 2020 | de Vidania S, Palomares-Perez I, Frank-García A, Saito T, Saido TC, Draffin J, Szaruga M, Chávez-Gutierrez L, Calero M, Medina M, Guix FX, Dotti CG. Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology. Frontiers in Neuroscience. 14: 562581. PMID 33343276 DOI: 10.3389/fnins.2020.562581 | 0.326 | |||
| 2020 | Shahnur A, Nakano M, Ishihara S, Kakuda N, Miyasaka T, Uchiyama H, Shirai Y, Moniruzzaman M, Saito T, Saido TC, Nishimura M, Funamoto S. A potential defense mechanism against amyloid deposition in cerebellum. Biochemical and Biophysical Research Communications. 535: 25-32. PMID 33340762 DOI: 10.1016/j.bbrc.2020.12.036 | 0.355 | |||
| 2020 | Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, Ali L, Saito T, Guillermier C, Saido TC, et al. Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. Cell Systems. PMID 33326751 DOI: 10.1016/j.cels.2020.11.007 | 0.351 | |||
| 2020 | Tanaka T, Hirai S, Hosokawa M, Saito T, Sakuma H, Saido T, Hasegawa M, Okado H. Early-life stress induces the development of Alzheimer's disease pathology via angiopathy. Experimental Neurology. 113552. PMID 33309748 DOI: 10.1016/j.expneurol.2020.113552 | 0.372 | |||
| 2020 | Saifullah MAB, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido TC, Yamanaka K, Mizoguchi H. Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease. Molecular Brain. 13: 147. PMID 33183323 DOI: 10.1186/s13041-020-00690-6 | 0.331 | |||
| 2020 | Chiasseu M, Fesharaki A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology of Disease. 145: 105059. PMID 32858147 DOI: 10.1016/J.Nbd.2020.105059 | 0.36 | |||
| 2020 | Latif-Hernandez A, Sabanov V, Ahmed T, Craessaerts K, Saito T, Saido T, Balschun D. The two faces of synaptic failure in App knock-in mice. Alzheimer's Research & Therapy. 12: 100. PMID 32838792 DOI: 10.1186/s13195-020-00667-6 | 0.346 | |||
| 2020 | Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 9. PMID 32510331 DOI: 10.7554/Elife.54083 | 0.365 | |||
| 2020 | Sos KE, Mayer MI, Takács VT, Major A, Bardóczi Z, Beres BM, Szeles T, Saito T, Saido TC, Mody I, Freund TF, Nyiri G. Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice. Plos One. 15: e0233700. PMID 32469963 DOI: 10.1371/journal.pone.0233700 | 0.399 | |||
| 2020 | Schedin-Weiss S, Nilsson P, Sandebring-Matton A, Axenhus M, Sekiguchi M, Saito T, Winblad B, Saido T, Tjernberg LO. Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 32280097 DOI: 10.3233/Jad-200028 | 0.39 | |||
| 2020 | Hongo N, Takamura Y, Nishimaru H, Matsumoto J, Tobe K, Saito T, Saido TC, Nishijo H. Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of Mice. Frontiers in Pharmacology. 11: 307. PMID 32218736 DOI: 10.3389/Fphar.2020.00307 | 0.373 | |||
| 2020 | Izumi H, Sato K, Kojima K, Saito T, Saido TC, Fukunaga K. Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in App knock-in mice. Neuropharmacology. 168: 108026. PMID 32130977 DOI: 10.1016/j.neuropharm.2020.108026 | 0.304 | |||
| 2020 | Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, ... ... Saido T, et al. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nature Communications. 11: 507. PMID 31980612 DOI: 10.1038/S41467-020-14353-6 | 0.336 | |||
| 2020 | Zhang F, Gannon M, Chen Y, Yan S, Zhang S, Feng W, Tao J, Sha B, Liu Z, Saito T, Saido T, Keene CD, Jiao K, Roberson ED, Xu H, et al. β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12. PMID 31941827 DOI: 10.1126/Scitranslmed.Aay6931 | 0.349 | |||
| 2020 | Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M. Nrf2 Suppresses Oxidative Stress and Inflammation in Knock-in Alzheimer's Disease Model Mice. Molecular and Cellular Biology. PMID 31932477 DOI: 10.1128/Mcb.00467-19 | 0.331 | |||
| 2020 | Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y | 0.381 | |||
| 2019 | Shinohara M, Tashiro Y, Shinohara M, Hirokawa J, Suzuki K, Onishi-Takeya M, Mukouzono M, Takeda S, Saito T, Fukumori A, Saido TC, Morishita R, Sato N. Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907998 DOI: 10.1096/fj.201901028RR | 0.314 | |||
| 2019 | Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31690660 DOI: 10.1073/Pnas.1908529116 | 0.352 | |||
| 2019 | Caleb AA, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H, Nakamura F, Saito T, Saido T, Goshima Y. Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. Neurobiology of Disease. 104603. PMID 31494281 DOI: 10.1016/j.nbd.2019.104603 | 0.377 | |||
| 2019 | Ni J, Wu Z, Meng J, Saito T, Saido TC, Qing H, Nakanishi H. An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain. Journal of Neuroinflammation. 16: 173. PMID 31470863 DOI: 10.1186/s12974-019-1562-9 | 0.317 | |||
| 2019 | Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK. Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice. Neurobiology of Aging. 81: 166-176. PMID 31284126 DOI: 10.1016/J.Neurobiolaging.2019.05.025 | 0.397 | |||
| 2019 | Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. Humanization of the entire murine gene provides a murine model of pathological human tau propagation. The Journal of Biological Chemistry. PMID 31273083 DOI: 10.1074/Jbc.Ra119.009487 | 0.345 | |||
| 2019 | Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, Gong H, Richard-Loendt A, Huang W, Saito T, Saido TC, et al. Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes. Science (New York, N.Y.). PMID 31221773 DOI: 10.1126/Science.Aav9518 | 0.332 | |||
| 2019 | Izuo N, Murakami K, Fujihara Y, Maeda M, Saito T, Saido TC, Irie K, Shimizu T. An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease. Biochemical and Biophysical Research Communications. PMID 31164199 DOI: 10.1016/j.bbrc.2019.05.131 | 0.379 | |||
| 2019 | Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T. Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature Communications. 10: 2394. PMID 31160584 DOI: 10.1038/s41467-019-10278-x | 0.376 | |||
| 2019 | Hamaguchi T, Tsutsui-Kimura I, Mimura M, Saito T, Saido TC, Tanaka KF. AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation. Neurochemistry International. 104470. PMID 31102607 DOI: 10.1016/j.neuint.2019.104470 | 0.37 | |||
| 2019 | Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099 | 0.311 | |||
| 2019 | Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. Bmc Neuroscience. 20: 13. PMID 30894120 DOI: 10.1186/s12868-019-0496-6 | 0.402 | |||
| 2019 | Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M. Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse. Biological & Pharmaceutical Bulletin. 42: 354-356. PMID 30828067 DOI: 10.1248/Bpb.B18-00899 | 0.384 | |||
| 2019 | Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. P4-471: AMYLOID-β PLAQUE FORMATION AND REACTIVE GLIOSIS ARE REQUIRED FOR INDUCTION OF COGNITIVE DEFICITS AND SYNAPTIC DEGENERATION IN APP KNOCK-IN MOUSE MODELS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1492-P1492. DOI: 10.1016/j.jalz.2019.08.017 | 0.325 | |||
| 2018 | Saito T, Saido TC. Neuroinflammation in mouse models of Alzheimer's disease. Clinical & Experimental Neuroimmunology. 9: 211-218. PMID 30546389 DOI: 10.1111/cen3.12475 | 0.333 | |||
| 2018 | Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone. Nature. PMID 30546139 DOI: 10.1038/S41586-018-0790-Y | 0.341 | |||
| 2018 | Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B. Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice. Journal of Alzheimer's Disease : Jad. PMID 30320577 DOI: 10.3233/Jad-180410 | 0.359 | |||
| 2018 | Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu SI, Fujita K, Okazawa H. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular Psychiatry. PMID 30283027 DOI: 10.1038/s41380-018-0253-8 | 0.352 | |||
| 2018 | Chen L, Saito T, Saido TC, Mody I. Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease. Eneuro. 5. PMID 30105300 DOI: 10.1523/ENEURO.0059-18.2018 | 0.321 | |||
| 2018 | Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. Bmc Neuroscience. 19: 46. PMID 30055565 DOI: 10.1186/s12868-018-0446-8 | 0.39 | |||
| 2018 | Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. Bmc Neuroscience. 19: 46. PMID 30055565 DOI: 10.1186/s12868-018-0446-8 | 0.39 | |||
| 2018 | Brown R, Lam AD, Gonzalez-Sulser A, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot AL, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, et al. Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. Eneuro. 5. PMID 29780880 DOI: 10.1523/ENEURO.0426-17.2018 | 0.303 | |||
| 2018 | Nagata K, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nature Communications. 9: 1800. PMID 29728560 DOI: 10.1038/s41467-018-04238-0 | 0.332 | |||
| 2018 | Shah D, Latif-Hernandez A, De Strooper B, Saito T, Saido T, Verhoye M, D'Hooge R, Van der Linden A. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP knock-in mice. Scientific Reports. 8: 6264. PMID 29674739 DOI: 10.1038/S41598-018-24657-9 | 0.399 | |||
| 2018 | Izumi H, Shinoda Y, Saito T, Saido T, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K. The disease-modifying drug candidate, SAK3 improves cognitive impairment and inhibits amyloid beta deposition in App knock-in mice. Neuroscience. PMID 29510211 DOI: 10.1016/j.neuroscience.2018.02.031 | 0.376 | |||
| 2018 | Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184 | 0.379 | |||
| 2018 | Hashimoto S, Ishii A, Kamano N, Watamura N, Saito T, Oshima T, Yokosuka M, Saido TC. Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm. The Journal of Biological Chemistry. PMID 29298895 DOI: 10.1074/Jbc.M117.811315 | 0.302 | |||
| 2018 | Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido TC, Tomita T, Sohma Y, Kanai M. Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide Chem. 4: 807-820. DOI: 10.1016/J.Chempr.2018.02.008 | 0.32 | |||
| 2017 | Hernandez AL, Shah D, Craessaerts K, Saido T, Saito T, De Strooper B, Van der Linden A, D'Hooge R. Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP(NL-G-F) mice before prominent plaque deposition. Behavioural Brain Research. PMID 29158112 DOI: 10.1016/j.bbr.2017.11.017 | 0.374 | |||
| 2017 | Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiology of Disease. PMID 29100987 DOI: 10.1016/J.Nbd.2017.10.014 | 0.358 | |||
| 2017 | Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, ... ... Saido TC, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/Pnas.1707151114 | 0.356 | |||
| 2017 | Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G. Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease. Plos One. 12: e0182844. PMID 28832675 DOI: 10.1371/Journal.Pone.0182844 | 0.347 | |||
| 2017 | Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397 | 0.356 | |||
| 2017 | Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, et al. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell. 170: 443-456.e14. PMID 28753424 DOI: 10.1016/J.Cell.2017.07.004 | 0.315 | |||
| 2016 | Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido TC. Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9933-6. PMID 27656030 DOI: 10.1523/JNEUROSCI.1907-16.2016 | 0.395 | |||
| 2016 | Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Scientific Reports. 6: 31895. PMID 27557632 DOI: 10.1038/Srep31895 | 0.342 | |||
| 2016 | Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S. Cognitive deficits in single App knock-in mouse models. Neurobiology of Learning and Memory. PMID 27377630 DOI: 10.1016/J.Nlm.2016.07.001 | 0.339 | |||
| 2016 | Nilsson P, Sekiguchi M, Saito T, Saido TC. P4-099: AB Secretion and Plaque Formation Depend on Autophagy in An App Knock-In Mouse Model of Alzheimer's Alzheimer's & Dementia. 12: P1050-P1050. DOI: 10.1016/j.jalz.2016.06.2152 | 0.301 | |||
| 2015 | Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... Saido TC, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/Scitranslmed.Aab3492 | 0.405 | |||
| 2015 | Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. The Biochemical Journal. PMID 26467158 DOI: 10.1042/BJ20150607 | 0.306 | |||
| 2015 | Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I. Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13275-86. PMID 26424877 DOI: 10.1523/Jneurosci.1034-15.2015 | 0.326 | |||
| 2015 | Nilsson P, Loganathan K, Sekiguchi M, Winblad B, Iwata N, Saido TC, Tjernberg LO. Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice. Proteomics. 15: 3349-55. PMID 26194619 DOI: 10.1002/pmic.201400211 | 0.392 | |||
| 2015 | Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. Embo Molecular Medicine. 7: 175-89. PMID 25592972 DOI: 10.15252/emmm.201404438 | 0.397 | |||
| 2015 | Thal DR, Walter J, Saido TC, Fändrich M. Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathologica. 129: 167-82. PMID 25534025 DOI: 10.1007/s00401-014-1375-y | 0.346 | |||
| 2015 | Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC. Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi. The American Journal of Pathology. 185: 305-13. PMID 25433221 DOI: 10.1016/j.ajpath.2014.10.011 | 0.393 | |||
| 2014 | Nilsson P, Saito T, Saido TC. New mouse model of Alzheimer's. Acs Chemical Neuroscience. 5: 499-502. PMID 24852598 DOI: 10.1021/cn500105p | 0.382 | |||
| 2014 | Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer's disease. Nature Neuroscience. 17: 661-3. PMID 24728269 DOI: 10.1038/nn.3697 | 0.387 | |||
| 2014 | Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 570-8. PMID 24711225 DOI: 10.1002/bies.201400002 | 0.31 | |||
| 2013 | Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Aβ secretion and plaque formation depend on autophagy. Cell Reports. 5: 61-9. PMID 24095740 DOI: 10.1016/j.celrep.2013.08.042 | 0.397 | |||
| 2013 | Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/J.Ajpath.2013.05.005 | 0.339 | |||
| 2013 | Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M. Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. Biochemistry. 52: 3532-42. PMID 23614719 DOI: 10.1021/bi301705c | 0.371 | |||
| 2013 | Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Scientific Reports. 3: 1472. PMID 23503602 DOI: 10.1038/srep01472 | 0.349 | |||
| 2013 | Saido T, Saito T, Matsuba Y, Yamazaki N. P.5.a.001 Single amyloid precursor protein (APP) locus knockin mouse models of Alzheimer's disease European Neuropsychopharmacology. 23: S535. DOI: 10.1016/S0924-977X(13)70849-6 | 0.32 | |||
| 2012 | Abramowski D, Rabe S, Upadhaya AR, Reichwald J, Danner S, Staab D, Capetillo-Zarate E, Yamaguchi H, Saido TC, Wiederhold KH, Thal DR, Staufenbiel M. Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1273-83. PMID 22279212 DOI: 10.1523/Jneurosci.4586-11.2012 | 0.392 | |||
| 2012 | Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1204-17. PMID 22173972 DOI: 10.1096/fj.11-187740 | 0.416 | |||
| 2012 | Nilsson P, Iwata N, Sekiguchi M, Saito T, Saido T. P4-014: Autophagy deficiency increases beta-amyloid pathology and memory impairment in APP transgenic mice Alzheimer's & Dementia. 8: P642-P642. DOI: 10.1016/j.jalz.2012.05.1715 | 0.32 | |||
| 2011 | Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K. An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3720-30. PMID 21746863 DOI: 10.1096/fj.11-182154 | 0.319 | |||
| 2011 | Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858 | 0.374 | |||
| 2011 | Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/Jneurosci.3076-10.2011 | 0.383 | |||
| 2010 | Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N. Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. The Journal of Biological Chemistry. 285: 40097-103. PMID 20952385 DOI: 10.1074/jbc.M110.144626 | 0.332 | |||
| 2010 | Nilsson P, Iwata N, Muramatsu S, Tjernberg LO, Winblad B, Saido TC. Gene therapy in Alzheimer's disease - potential for disease modification. Journal of Cellular and Molecular Medicine. 14: 741-57. PMID 20158567 DOI: 10.1111/J.1582-4934.2010.01038.X | 0.332 | |||
| 2009 | Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. International Journal of Alzheimer's Disease. 2009. PMID 20798763 DOI: 10.4061/2009/689285 | 0.382 | |||
| 2009 | Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, et al. Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. The Journal of Biological Chemistry. 284: 33400-8. PMID 19679659 DOI: 10.1074/jbc.M109.054056 | 0.382 | |||
| 2009 | Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. Journal of Neurochemistry. 109: 1648-57. PMID 19457098 DOI: 10.1111/j.1471-4159.2009.06069.x | 0.382 | |||
| 2008 | Nakajima R, Takao K, Huang SM, Takano J, Iwata N, Miyakawa T, Saido TC. Comprehensive behavioral phenotyping of calpastatin-knockout mice. Molecular Brain. 1: 7. PMID 18803809 DOI: 10.1186/1756-6606-1-7 | 0.538 | |||
| 2008 | Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry. 47: 7405-13. PMID 18570439 DOI: 10.1021/bi800250p | 0.302 | |||
| 2008 | Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... Saido TC, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/J.Brainres.2008.03.079 | 0.373 | |||
| 2008 | Iwata N, Tsubuki S, Higuchi M, Watanabe K, Staufenbiel M, Mann DM, Saido TC. P1-434: Accumulation of Aβ starting with pyroglutamate at position 3 in the brain and its impact on amyloid pathology of Alzheimer's disease Alzheimer's & Dementia. 4: T346-T347. DOI: 10.1016/J.Jalz.2008.05.1016 | 0.34 | |||
| 2007 | Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, Staufenbiel M, Iwata N, Ono M, Saido TC, Suzuki K, Mori H, Higuchi M, Suhara T. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10957-68. PMID 17928437 DOI: 10.1523/JNEUROSCI.0673-07.2007 | 0.362 | |||
| 2007 | Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53: 337-51. PMID 17270732 DOI: 10.1016/J.Neuron.2007.01.010 | 0.344 | |||
| 2007 | Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K. Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochemical and Biophysical Research Communications. 352: 498-502. PMID 17125739 DOI: 10.1016/j.bbrc.2006.11.043 | 0.365 | |||
| 2006 | Higuchi M, Saido TC, Suhara T. Animal models of tauopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 26: 491-7. PMID 17080730 DOI: 10.1111/j.1440-1789.2006.00685.x | 0.381 | |||
| 2006 | Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama K, Mizutani S, Ishiura S. BACE1 interacts with lipid raft proteins. Journal of Neuroscience Research. 84: 912-7. PMID 16823808 DOI: 10.1002/jnr.20981 | 0.302 | |||
| 2006 | Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K. Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1. Brain Research. 1094: 192-9. PMID 16713590 DOI: 10.1016/J.Brainres.2005.12.134 | 0.362 | |||
| 2006 | Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai H. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. Journal of Neuroscience Research. 84: 427-33. PMID 16676329 DOI: 10.1002/jnr.20891 | 0.325 | |||
| 2006 | Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N. Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. The Journal of Biological Chemistry. 281: 17941-51. PMID 16636059 DOI: 10.1074/jbc.M601372200 | 0.573 | |||
| 2006 | Saido TC, Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neuroscience Research. 54: 235-53. PMID 16457902 DOI: 10.1016/j.neures.2005.12.015 | 0.363 | |||
| 2006 | Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T, Hashimoto Y. Sialylation enhances the secretion of neurotoxic amyloid-beta peptides. Journal of Neurochemistry. 96: 924-33. PMID 16412100 DOI: 10.1111/j.1471-4159.2005.03595.x | 0.346 | |||
| 2006 | Zou LB, Mouri A, Iwata N, Saido TC, Wang D, Wang MW, Mizoguchi H, Noda Y, Nabeshima T. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. The Journal of Pharmacology and Experimental Therapeutics. 317: 334-40. PMID 16382024 DOI: 10.1124/jpet.105.095687 | 0.331 | |||
| 2006 | Mouri A, Zou LB, Iwata N, Saido TC, Wang D, Wang MW, Noda Y, Nabeshima T. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioural Brain Research. 168: 83-91. PMID 16360221 DOI: 10.1016/j.bbr.2005.10.014 | 0.346 | |||
| 2006 | Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. Journal of Neurochemistry. 96: 533-40. PMID 16336629 DOI: 10.1111/j.1471-4159.2005.03576.x | 0.353 | |||
| 2006 | Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters. 395: 37-41. PMID 16298484 DOI: 10.1016/J.Neulet.2005.10.087 | 0.349 | |||
| 2006 | Fukunaga K, Izumi H, Shinoda Y, Yabuki Y, Saito T, Saido TC. P2-050: DECREASE IN AMYLOID PLAQUE FORMATION BY DISEASE-MODIFYING DRUG SAK3 IN APP KNOCK-IN MICE Alzheimer's & Dementia. 14: P685-P685. DOI: 10.1016/j.jalz.2018.06.734 | 0.312 | |||
| 2005 | Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/S00401-005-1053-1 | 0.32 | |||
| 2005 | Iwata N, Higuchi M, Saido TC. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacology & Therapeutics. 108: 129-48. PMID 16112736 DOI: 10.1016/j.pharmthera.2005.03.010 | 0.389 | |||
| 2005 | Piccini A, Russo C, Gliozzi A, Relini A, Vitali A, Borghi R, Giliberto L, Armirotti A, D'Arrigo C, Bachi A, Cattaneo A, Canale C, Torrassa S, Saido TC, Markesbery W, et al. beta-amyloid is different in normal aging and in Alzheimer disease. The Journal of Biological Chemistry. 280: 34186-92. PMID 16103127 DOI: 10.1074/Jbc.M501694200 | 0.307 | |||
| 2005 | Higuchi M, Iwata N, Saido TC. Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochimica Et Biophysica Acta. 1751: 60-7. PMID 16054018 DOI: 10.1016/j.bbapap.2005.02.013 | 0.427 | |||
| 2005 | Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Annals of Neurology. 57: 832-42. PMID 15929037 DOI: 10.1002/ana.20494 | 0.362 | |||
| 2005 | Hama E, Saido TC. Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide. Medical Hypotheses. 65: 498-500. PMID 15921860 DOI: 10.1016/j.mehy.2005.02.045 | 0.342 | |||
| 2005 | Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC. Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nature Medicine. 11: 434-9. PMID 15778722 DOI: 10.1038/nm1206 | 0.391 | |||
| 2005 | Iwata N, Ozawa K, Saido TC. [Gene therapy for Alzheimer' s disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 63: 394-400. PMID 15773336 | 0.379 | |||
| 2005 | Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC. 19F and 1H MRI detection of amyloid beta plaques in vivo. Nature Neuroscience. 8: 527-33. PMID 15768036 DOI: 10.1038/nn1422 | 0.342 | |||
| 2005 | Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S, Saido TC. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. The Journal of Biological Chemistry. 280: 15229-37. PMID 15699033 DOI: 10.1074/jbc.M500939200 | 0.314 | |||
| 2004 | Saido TC. [Towards presymptomatic diagnosis, prevention and treatment of Alzheimer's disease]. Rinshå Shinkeigaku = Clinical Neurology. 44: 775-7. PMID 15651288 | 0.342 | |||
| 2004 | Kitazume S, Saido TC, Hashimoto Y. Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconjugate Journal. 20: 59-62. PMID 14973371 DOI: 10.1023/B:GLYC.0000016743.25495.45 | 0.328 | |||
| 2004 | Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 991-8. PMID 14749444 DOI: 10.1523/Jneurosci.4792-03.2004 | 0.386 | |||
| 2004 | Higuchi M, Takano J, Iwata N, Sekiguchi M, Saido TC. P1-234 Contribution of calpains and caspases to Abeta-induced neuritic and synaptic pathologies in Alzheimer's disease patients and amyloid precursor protein transgenic mice Neurobiology of Aging. 25: S163. DOI: 10.1016/S0197-4580(04)80547-5 | 0.387 | |||
| 2003 | Wang DS, Iwata N, Hama E, Saido TC, Dickson DW. Oxidized neprilysin in aging and Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 310: 236-41. PMID 14511676 DOI: 10.1016/J.Bbrc.2003.09.003 | 0.336 | |||
| 2003 | Saito T, Takaki Y, Iwata N, Trojanowski J, Saido TC. Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism. Science of Aging Knowledge Environment : Sage Ke. 2003: PE1. PMID 12844556 DOI: 10.1126/Sageke.2003.3.Pe1 | 0.381 | |||
| 2003 | Iwata N, Saido TC. [Amyloid-beta peptide metabolism and Alzheimer's disease]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 122: 5-14. PMID 12843567 DOI: 10.1254/fpj.122.5 | 0.401 | |||
| 2002 | Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. Journal of Neuroscience Research. 70: 493-500. PMID 12391610 DOI: 10.1002/jnr.10390 | 0.342 | |||
| 2002 | Shirotani K, Tsubuki S, Lee HJ, Maruyama K, Saido TC. Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. Neuroscience Letters. 327: 25-8. PMID 12098492 DOI: 10.1016/S0304-3940(02)00351-8 | 0.321 | |||
| 2002 | Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neuroscience Research. 43: 39-56. PMID 12074840 DOI: 10.1016/S0168-0102(02)00015-9 | 0.393 | |||
| 2002 | Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 accumulation in Down syndrome brain Amyloid. 9: 88-102. DOI: 10.3109/13506120208995241 | 0.357 | |||
| 2002 | Fukami S, Iwata N, Saido TC. Therapeutic strategies of Alzheimer's disease through manipulation of Aβ metabolism: A focus on Aβ-degrading peptidase, neprilysin Drug Development Research. 56: 171-183. DOI: 10.1002/ddr.10073 | 0.3 | |||
| 2001 | Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC. Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons. Journal of Biochemistry. 130: 721-6. PMID 11726269 | 0.354 | |||
| 2001 | Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 98: 13554-9. PMID 11698669 DOI: 10.1073/pnas.241509198 | 0.303 | |||
| 2001 | Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Metabolic regulation of brain Abeta by neprilysin. Science (New York, N.Y.). 292: 1550-2. PMID 11375493 DOI: 10.1126/Science.1059946 | 0.378 | |||
| 2001 | Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 372-81. PMID 11160418 | 0.354 | |||
| 2000 | Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee HJ, Shirotani K, Saido TC. Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. Journal of Biochemistry. 128: 897-902. PMID 11098130 DOI: 10.1093/Oxfordjournals.Jbchem.A022839 | 0.305 | |||
| 2000 | Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochemical and Biophysical Research Communications. 276: 422-7. PMID 11027491 DOI: 10.1006/Bbrc.2000.3490 | 0.341 | |||
| 2000 | Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403 DOI: 10.1016/S0002-9440(10)64544-0 | 0.347 | |||
| 2000 | Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM, Trojanowski JQ. Brain trauma in aged transgenic mice induces regression of established abeta deposits. Experimental Neurology. 163: 244-52. PMID 10785464 DOI: 10.1006/Exnr.2000.7375 | 0.396 | |||
| 2000 | Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S. Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice. The Journal of Pathology. 191: 93-101. PMID 10767725 DOI: 10.1002/(Sici)1096-9896(200005)191:1<93::Aid-Path567>3.0.Co;2-Q | 0.331 | |||
| 2000 | Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nature Medicine. 6: 143-50. PMID 10655101 DOI: 10.1038/72237 | 0.321 | |||
| 1999 | Schmidt ML, Saido TC, Lee VM, Trojanowski JQ. Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 58: 1227-33. PMID 10604747 DOI: 10.1097/00005072-199912000-00003 | 0.314 | |||
| 1999 | McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/Nbdi.1999.0243 | 0.378 | |||
| 1999 | Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ. Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. The Journal of Comparative Neurology. 411: 390-8. PMID 10413774 DOI: 10.1002/(Sici)1096-9861(19990830)411:3<390::Aid-Cne3>3.0.Co;2-# | 0.395 | |||
| 1999 | Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 25: 324-31. PMID 10028915 DOI: 10.1002/(Sici)1098-1136(19990215)25:4<324::Aid-Glia2>3.0.Co;2-5 | 0.304 | |||
| 1998 | Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido TC, Cole GM. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8311-21. PMID 9763475 | 0.353 | |||
| 1998 | Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X | 0.34 | |||
| 1998 | Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359 | 0.305 | |||
| 1998 | Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathologica. 95: 117-22. PMID 9498044 DOI: 10.1007/S004010050774 | 0.333 | |||
| 1998 | Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. The American Journal of Pathology. 152: 307-17. PMID 9422548 | 0.384 | |||
| 1998 | Schmidt ML, -Y. Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Troianowski JO. AMYLOID PLAQUES IN GUAM AMYOTROPHIC LATERAL SCLEROSIS/AND PARKINSONISM-DEMENTIA COMPLEX (ALS/PDC) CONTAIN SPECIES OF Aβ SIMILAR TO THOSE FOUND IN THE AMYLOID PLAQUES OF ALZHEIMERʼS DISEASE (AD) AND PATHOLOGICAL AGING (PA) Journal of Neuropathology and Experimental Neurology. 57: 475. DOI: 10.1097/00005072-199805000-00037 | 0.308 | |||
| 1997 | Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature. 389: 689-95. PMID 9338779 DOI: 10.1038/39522 | 0.312 | |||
| 1997 | Shin RW, Ogino K, Kondo A, Saido TC, Trojanowski JQ, Kitamoto T, Tateishi J. Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8187-93. PMID 9334394 | 0.326 | |||
| 1997 | Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y | 0.341 | |||
| 1997 | Kuda T, Shoji M, Arai H, Kawashima S, Saido TC. Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease. Biochemical and Biophysical Research Communications. 231: 526-30. PMID 9070837 DOI: 10.1006/bbrc.1996.5920 | 0.31 | |||
| 1997 | Shin R, Ogino K, Kondo A, Saido TC, Trojanowski JQ, Kitamoto T, Tateishi J. Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain The Journal of Neuroscience. 17: 8187-8193. DOI: 10.1523/Jneurosci.17-21-08187.1997 | 0.337 | |||
| 1996 | Shin R, Ogino K, Saido T, Kitamoto T, Trojanowski J, Tateishi J. 253 Assembly of soluble β-amyloid peptides into Alzheimer disease amyloid fibrils in rat brain Neurobiology of Aging. 17: S63-S64. DOI: 10.1016/S0197-4580(96)80255-7 | 0.302 | |||
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