Sian Harding - Publications

Affiliations: 
National Heart and Lung Institute Imperial College London, London, England, United Kingdom 

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Tranter MH, Redfors B, Wright PT, Couch LS, Lyon AR, Omerovic E, Harding SE. Corrigendum: Hyperthermia as a trigger for Takotsubo syndrome in a rat model. Frontiers in Cardiovascular Medicine. 9: 1021913. PMID 36119743 DOI: 10.3389/fcvm.2022.1021913  0.762
2022 Tranter MH, Redfors B, Wright PT, Couch LS, Lyon AR, Omerovic E, Harding SE. Hyperthermia as a trigger for Takotsubo syndrome in a rat model. Frontiers in Cardiovascular Medicine. 9: 869585. PMID 35958426 DOI: 10.3389/fcvm.2022.869585  0.782
2021 Wright PT, Gorelik J, Harding SE. Electrophysiological Remodeling: Cardiac T-Tubules and ß-Adrenoceptors. Cells. 10. PMID 34572106 DOI: 10.3390/cells10092456  0.789
2021 Jabbour RJ, Owen TJ, Pandey P, Reinsch M, Wang B, King O, Couch LS, Pantou D, Pitcher DS, Chowdhury RA, Pitoulis FG, Handa BS, Kit-Anan W, Perbellini F, Myles RC, ... ... Harding SE, et al. In vivo grafting of large engineered heart tissue patches for cardiac repair. Jci Insight. 6. PMID 34369384 DOI: 10.1172/jci.insight.144068  0.613
2021 Basnett P, Matharu RK, Taylor CS, Illangakoon U, Dawson JI, Kanczler JM, Behbehani M, Humphrey E, Majid Q, Lukasiewicz B, Nigmatullin R, Heseltine P, Oreffo ROC, Haycock JW, Terracciano C, ... Harding SE, et al. Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering. Acs Applied Materials & Interfaces. PMID 34228435 DOI: 10.1021/acsami.0c19689  0.502
2021 Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, ... ... Harding SE, et al. Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure. Cardiovascular Research. PMID 34155498 DOI: 10.1093/cvr/cvab210  0.779
2021 Pitoulis FG, Nunez-Toldra R, Xiao K, Kit-Anan W, Mitzka S, Jabbour RJ, Harding SE, Perbellini F, Thum T, de Tombe PP, Terracciano CM. Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro. Cardiovascular Research. PMID 33723566 DOI: 10.1093/cvr/cvab084  0.557
2021 Kit-Anan W, Mazo MM, Wang BX, Leonardo V, Pence IJ, Gopal S, Gelmi A, Nagelkerke A, Becce M, Chiappini C, Harding SE, Terracciano CM, Stevens MM. Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation. Biofabrication. 13: 025004. PMID 33710972 DOI: 10.1088/1758-5090/abce0a  0.549
2021 Kondrashov A, Mohd Yusof NAN, Hasan A, Goulding J, Kodagoda T, Hoang DM, Vo NTN, Melarangi T, Dolatshad N, Gorelik J, Hill SJ, Harding SE, Denning C. CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of βAR in isogenic hPSC-derived cardiomyocytes. Molecular Therapy. Methods & Clinical Development. 20: 39-53. PMID 33335946 DOI: 10.1016/j.omtm.2020.10.019  0.688
2020 Forte E, Panahi M, Baxan N, Ng FS, Boyle JJ, Branca J, Bedard O, Hasham MG, Benson L, Harding SE, Rosenthal N, Sattler S. Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. Journal of Cellular and Molecular Medicine. PMID 33249764 DOI: 10.1111/jcmm.15937  0.307
2020 Hasan A, Mohammadi N, Nawaz A, Kodagoda T, Diakonov I, Harding SE, Gorelik J. Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of βAR-cAMP Signalling. Cells. 9. PMID 33053822 DOI: 10.3390/cells9102275  0.714
2020 Crestani T, Steichen C, Neri E, Rodrigues M, Fonseca-Alaniz MH, Ormrod B, Holt MR, Pandey P, Harding S, Ehler E, Krieger JE. Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells. Biochemical and Biophysical Research Communications. PMID 32962862 DOI: 10.1016/J.Bbrc.2020.09.021  0.375
2020 Meijles DN, Cull JJ, Markou T, Cooper STE, Haines ZHR, Fuller SJ, O'Gara P, Sheppard MN, Harding SE, Sugden PH, Clerk A. Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. Hypertension (Dallas, Tex. : 1979). 76: 1208-1218. PMID 32903101 DOI: 10.1161/HYPERTENSIONAHA.119.14556  0.301
2020 Brook J, Kim MY, Koutsoftidis S, Pitcher D, Agha-Jaffar D, Sufi A, Jenkins C, Tzortzis K, Ma S, Jabbour RJ, Houston C, Handa BS, Li X, Chow JJ, Jothidasan A, ... ... Harding S, et al. Development of a pro-arrhythmic ex vivo intact human and porcine model: cardiac electrophysiological changes associated with cellular uncoupling. Pflugers Archiv : European Journal of Physiology. PMID 32870378 DOI: 10.1007/S00424-020-02446-6  0.383
2020 Sintou A, Mansfield C, Iacob A, Chowdhury RA, Narodden S, Rothery SM, Podovei R, Sanchez-Alonso JL, Ferraro E, Swiatlowska P, Harding SE, Prasad S, Rosenthal N, Gorelik J, Sattler S. Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans. Frontiers in Cell and Developmental Biology. 8: 695. PMID 32850816 DOI: 10.3389/Fcell.2020.00695  0.719
2020 Constantinou C, Miranda AMA, Chaves P, Bellahcene M, Massaia A, Cheng K, Samari S, Rothery SM, Chandler AM, Schwarz RP, Harding SE, Punjabi P, Schneider MD, Noseda M. Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Scientific Reports. 10: 13016. PMID 32747668 DOI: 10.1038/s41598-020-69495-w  0.309
2020 Lyon AR, Babalis D, Morley-Smith AC, Hedger M, Suarez Barrientos A, Foldes G, Couch LS, Chowdhury RA, Tzortzis KN, Peters NS, Rog-Zielinska EA, Yang HY, Welch S, Bowles CT, Rahman Haley S, ... ... Harding SE, et al. Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL. Gene Therapy. PMID 32669717 DOI: 10.1038/S41434-020-0171-7  0.713
2020 Schobesberger S, Wright PT, Poulet C, Sanchez Alonso Mardones JL, Mansfield C, Friebe A, Harding SE, Balligand JL, Nikolaev VO, Gorelik J. β-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes. Elife. 9. PMID 32228862 DOI: 10.7554/Elife.52221  0.802
2020 Pitoulis FG, Hasan W, Papadaki M, Clavere NG, Perbellini F, Harding SE, Kirk JA, Boateng SY, de Tombe PP, Terracciano CM. Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics. Journal of Molecular and Cellular Cardiology. PMID 32201175 DOI: 10.1016/J.Yjmcc.2020.03.007  0.609
2020 Schobesberger S, Wright PT, Poulet C, Mardones JLSA, Mansfield C, Friebe A, Harding SE, Balligand J, Nikolaev VO, Gorelik J. Author response: β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes Elife. DOI: 10.7554/Elife.52221.Sa2  0.766
2020 Pitoulis FG, Nunez-Toldra R, Kit-Anan WS, Dries E, Bardi I, Perbellini F, Harding SE, Tombe PPd, Terracciano CM. Exploring Mechanical Load-Induced Cardiac Remodelling Using a Novel Organotypic Myocardial Slice Model Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2392  0.566
2019 Ramuz M, Hasan A, Gruscheski L, Diakonov I, Pavlaki N, Nikolaev VO, Harding S, Dunsby C, Gorelik J. A Software Tool for High-Throughput Real-Time Measurement of Intensity-Based Ratio-Metric FRET. Cells. 8. PMID 31795419 DOI: 10.3390/Cells8121541  0.744
2019 Gintant G, Burridge P, Gepstein L, Harding S, Herron T, Hong C, Jalife J, Wu JC. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association. Circulation Research. RES0000000000000291. PMID 31533542 DOI: 10.1161/Res.0000000000000291  0.361
2019 Watson SA, Duff J, Bardi I, Zabielska M, Atanur SS, Jabbour RJ, Simon A, Tomas A, Smolenski RT, Harding SE, Perbellini F, Terracciano CM. Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro. Nature Communications. 10: 2168. PMID 31092830 DOI: 10.1038/S41467-019-10175-3  0.598
2019 Jabbour R, Owen T, Reinsch M, Pandey P, Terracciano C, Weinberger F, Eschenhagen T, Harding S. BS27 Development and preclinical testing of a large heart muscle patch Heart. 105. DOI: 10.1136/Heartjnl-2019-Bcs.190  0.637
2019 Pitoulis F, Perbellini F, Harding SE, Tombe PD, Terracciano CM. P5373Mechanical heterogeneity across the left ventricular wall - a study using intact multicellular preparations European Heart Journal. 40. DOI: 10.1093/Eurheartj/Ehz746.0336  0.512
2018 Adamowicz M, Morgan CC, Haubner BJ, Noseda M, Collins MJ, Abreu Paiva M, Srivastava PK, Gellert P, Razzaghi B, O'Gara P, Raina P, Game L, Bottolo L, Schneider MD, Harding SE, et al. Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human. Circulation. Genomic and Precision Medicine. 11: e001805. PMID 32966096 DOI: 10.1161/Circgen.117.001805  0.319
2018 Kapnisi M, Mansfield C, Marijon C, Guex AG, Perbellini F, Bardi I, Humphrey EJ, Puetzer JL, Mawad D, Koutsogeorgis DC, Stuckey DJ, Terracciano CM, Harding SE, Stevens MM. Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction. Advanced Functional Materials. 28: 1800618. PMID 29875619 DOI: 10.1002/Adfm.201800618  0.609
2018 Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, et al. Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in βAR-cAMP Responsiveness in Murine Hearts. Cell Reports. 23: 459-469. PMID 29642004 DOI: 10.1016/J.Celrep.2018.03.053  0.796
2018 Ricardo C, Hellen N, Foldes G, Kodagoda T, Terracciano C, Duchen, Harding S. P19 Low levels of the A3243G MTDNA mutation in human induced pluripotent stem cell-cardiomyocytes do not cause functional or metabolic disturbances but increase with further passaging Heart. DOI: 10.1136/Heartjnl-2018-Bscr.24  0.555
2018 Watson SA, Duff JD, Bardi IB, Zabielska M, Atanur SS, Jabbour RJ, Smolenski RT, Harding SE, Perbellini F, Terracciano CM. 5330A novel platform to maintain adult cardiac tissue in vitro: myocardial slices and electromechanical stimulation with physiological preload European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy566.5330  0.55
2018 Panahi M, Papanikolaou A, Khan H, Torabi A, Cleland JGF, Vadgama N, Rosenthal NA, Harding S, Sattler S. P2861A systematic review and meta-analysis of anti-cytokine therapies targeting IL-1 and TNF- A in myocardial infarction and heart failure European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy565.P2861  0.321
2018 Narodden S, Baxan N, Harding S. 4384High-frame rate cine-MRI reveals systolic and diastolic functional abnormalities in the remote segments of ischaemia-reperfusion myocardial infarction European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy563.4384  0.307
2017 Todd Milne G, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS, Wong D, Sarko C, Fryer R, Richman J, Reinhart GA, Boustany CM, Pullen SS, ... ... Harding SE, et al. Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017. Bmc Pharmacology & Toxicology. 18: 64. PMID 29035170 DOI: 10.1186/s40360-017-0170-5  0.737
2017 Sikkel MB, Francis DP, Howard J, Gordon F, Rowlands C, Peters NS, Lyon AR, Harding SE, MacLeod KT. Hierarchical Statistical Techniques are Necessary to Draw Reliable Conclusions from Analysis of Isolated Cardiomyocyte Studies. Cardiovascular Research. PMID 29016722 DOI: 10.1093/Cvr/Cvx151  0.626
2017 Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C, Dufton NP, Simon A, Sikkel MB, Faggian G, Randi AM, Gorelik J, Harding SE, et al. Investigation of cardiac fibroblasts using myocardial slices. Cardiovascular Research. PMID 29016704 DOI: 10.1093/Cvr/Cvx152  0.759
2017 Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh HAM, Ramu E, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, ... ... Harding SE, et al. Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis. Human Molecular Genetics. PMID 28521042 DOI: 10.1093/hmg/ddx140  0.326
2017 Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik J. T-tubule remodelling disturbs localised β2-adrenergic signalling in rat ventricular myocyte during the progression of heart failure. Cardiovascular Research. PMID 28505272 DOI: 10.1093/Cvr/Cvx074  0.802
2017 Sikkel MB, Kumar S, Maioli V, Rowlands C, Gordon F, Harding SE, Lyon AR, MacLeod KT, Dunsby C. Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes: [J. Biophotonics 9, No. 3, 311-323 (2016)]. Journal of Biophotonics. 10: 744-745. PMID 28498628 DOI: 10.1002/Jbio.201700062  0.574
2017 Couch L, Derda AA, Thum T, Terracciano C, Harding S. 199 Takotsubo syndrome associated mir-16 and mir-26a reduce contractility of cardiomyocytes in vitro by an inhibitory g-?protein dependent mechanism Heart. 103. DOI: 10.1136/Heartjnl-2017-311726.197  0.556
2017 Leong K, Ng F, Shun-Shin M, Davies N, Francis D, Lim P, Qureshi N, Koa-Wing M, Linton N, Whinnett Z, Lefroy D, Harding S, Davies D, Peters N, Behr E, et al. 1Non-invasive detection of exercise induced cardiac conduction abnormalities in sudden cardiac death survivors in the inherited arrhythmic syndromes Europace. 19. DOI: 10.1093/Europace/Eux283.141A  0.327
2017 Watson SA, Perbellini F, Harding SE, Terracciano CM. P5840Structural and functional plasticity of myocardial slices in response to prolonged mechanical loading and unloading in vitro European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P5840  0.516
2016 Mawad D, Mansfield C, Lauto A, Perbellini F, Nelson GW, Tonkin J, Bello SO, Carrad DJ, Micolich AP, Mahat MM, Furman J, Payne D, Lyon AR, Gooding JJ, Harding SE, et al. A conducting polymer with enhanced electronic stability applied in cardiac models. Science Advances. 2: e1601007. PMID 28138526 DOI: 10.1126/Sciadv.1601007  0.711
2016 Bagdadi AV, Safari M, Dubey P, Basnett P, Sofokleous P, Humphrey E, Locke I, Edirisinghe M, Terracciano C, Boccaccini AR, Knowles JC, Harding SE, Roy I. Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. PMID 27689781 DOI: 10.1002/Term.2318  0.55
2015 Sikkel MB, Kumar S, Maioli V, Rowlands C, Gordon F, Harding SE, Lyon AR, MacLeod KT, Dunsby C. High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes. Journal of Biophotonics. PMID 26488431 DOI: 10.1002/Jbio.201500193  0.613
2015 Roca-Alonso L, Castellano L, Mills A, Dabrowska AF, Sikkel MB, Pellegrino L, Jacob J, Frampton AE, Krell J, Coombes RC, Harding SE, Lyon AR, Stebbing J. Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis. Cell Death & Disease. 6: e1754. PMID 25950484 DOI: 10.1038/cddis.2015.89  0.609
2015 Hayward C, Banner NR, Morley-Smith A, Lyon AR, Harding SE. The Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective. Human Gene Therapy. 26: 293-304. PMID 25914929 DOI: 10.1089/hum.2015.018  0.62
2015 Merkely B, Gara E, Lendvai Z, Skopál J, Leja T, Zhou W, Kosztin A, Várady G, Mioulane M, Bagyura Z, Németh T, Harding SE, Földes G. Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells. Stem Cells and Development. 24: 869-78. PMID 25387407 DOI: 10.1093/Cvr/Cvu082.21  0.313
2015 Chahine MN, Mioulane M, Sikkel MB, O'Gara P, Dos Remedios CG, Pierce GN, Lyon AR, Földes G, Harding SE. Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. Cardiovascular Research. 105: 31-43. PMID 25341891 DOI: 10.1093/Cvr/Cvu218  0.652
2015 Dyer B, Elder J, Lagarto J, Harding S, French P, Peters N, Dunsby C, Lyon A. 165 Label-free autofluorescence lifetime to assess changes in myocardial fibrosis and metabolism in vivo in a doxorubicin cardiomyopathy heart failure model Heart. 101. DOI: 10.1136/Heartjnl-2015-308066.165  0.684
2014 Land S, Niederer SA, Louch WE, Røe Ã…T, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP. Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 307: H1487-96. PMID 25239804 DOI: 10.1152/ajpheart.00443.2014  0.646
2014 Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J. Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. Journal of Molecular and Cellular Cardiology. 67: 38-48. PMID 24345421 DOI: 10.1016/J.Yjmcc.2013.12.003  0.791
2014 Sikkel MB, Hayward C, MacLeod KT, Harding SE, Lyon AR. SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope. British Journal of Pharmacology. 171: 38-54. PMID 24138023 DOI: 10.1111/Bph.12472  0.666
2014 Fiedler L, Jenkins M, Maifoshie E, Harada M, Stuckey D, Song W, Sampson R, Harding S, Schneider. Map4K4 Mediates Cardiomyocyte Cell Death And Potentiates A Heart Failure Phenotype Heart. 100. DOI: 10.1136/Heartjnl-2014-306916.60  0.374
2014 Tranter M, Wright P, Lyon A, Harding S. P763Ovariectomy increases epinephrine-induced mortality in a rat takotsubo cardiomyopathy model: the effects of estrogen supplementation Cardiovascular Research. 103. DOI: 10.1093/Cvr/Cvu098.182  0.773
2014 Mills AM, Sikkel M, Kumarswamy R, Macleod K, Lyon A, Thum T, Harding S. P393miR-1: a link between SERCA2a and the Beta-Adrenoceptor in the failing heart? Cardiovascular Research. 103: S72.3-S72. DOI: 10.1093/Cvr/Cvu091.75  0.649
2014 Hellen N, Wheeler J, Ricardo CP, Foldes G, Kodagoda T, Whiting G, Mioulane M, Terracciano C, Vauchez K, Harding S. P343Effect of T3 on human induced pluripotent stem cell-derived cardiomyocyte maturation Cardiovascular Research. 103. DOI: 10.1093/Cvr/Cvu091.29  0.588
2014 Zhou W, Vilar R, Ying L, Harding S. P491Transcriptional regulatory roles of G-quadruplex DNA in promoters of genes involved in beta-adrenergic signaling pathway Cardiovascular Research. 103. DOI: 10.1093/Cvr/Cvu091.165  0.315
2014 Roca-Alonso L, Castellano L, Mills A, Harding S, Lyon A, Stebbing J. P65Myocardial miR-30 down-regulation caused by doxorubicin alters the beta-adrenergic system and mitochondrial death pathways Cardiovascular Research. 103. DOI: 10.1093/Cvr/Cvu082.9  0.639
2013 Harding S. Heart failure therapy: drugs, genes or stem cells?: by Caroline Telfer. Future Cardiology. 9: 629-33. PMID 24020663 DOI: 10.2217/Fca.13.64  0.369
2013 Sikkel MB, Collins TP, Rowlands C, Shah M, O'Gara P, Williams AJ, Harding SE, Lyon AR, MacLeod KT. Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply. Cardiovascular Research. 98: 327-8. PMID 23536607 DOI: 10.1093/Cvr/Cvt068  0.592
2013 Gorelik J, Wright PT, Lyon AR, Harding SE. Spatial control of the βAR system in heart failure: the transverse tubule and beyond. Cardiovascular Research. 98: 216-24. PMID 23345264 DOI: 10.1093/Cvr/Cvt005  0.81
2013 Sikkel MB, Collins TP, Rowlands C, Shah M, O'Gara P, Williams AJ, Harding SE, Lyon AR, MacLeod KT. Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current. Cardiovascular Research. 98: 286-96. PMID 23334259 DOI: 10.1093/Cvr/Cvt012  0.564
2013 Rao C, Prodromakis T, Kolker L, Chaudhry UA, Trantidou T, Sridhar A, Weekes C, Camelliti P, Harding SE, Darzi A, Yacoub MH, Athanasiou T, Terracciano CM. The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells. Biomaterials. 34: 2399-411. PMID 23261219 DOI: 10.1016/J.Biomaterials.2012.11.055  0.543
2013 Khan JM, Lyon AR, Harding SE. The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. British Journal of Pharmacology. 169: 304-17. PMID 22845396 DOI: 10.1111/j.1476-5381.2012.02118.x  0.602
2013 Sikkel M, Rowlands C, Harding S, Lyon A, MacLeod K. 221 REDUCING SARCOLEMMAL SODIUM CURRENT DECREASES SPONTANEOUS SR CA2+ RELEASE Heart. 99: A120.1-A120. DOI: 10.1136/Heartjnl-2013-304019.221  0.613
2012 Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, ... ... Harding SE, et al. High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 126: 697-706. PMID 22732314 DOI: 10.1161/Circulationaha.112.111591  0.798
2012 Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J. Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circulation. Heart Failure. 5: 357-65. PMID 22456061 DOI: 10.1161/Circheartfailure.111.964692  0.822
2012 Kumarswamy R, Lyon AR, Volkmann I, Mills AM, Bretthauer J, Pahuja A, Geers-Knörr C, Kraft T, Hajjar RJ, Macleod KT, Harding SE, Thum T. SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. European Heart Journal. 33: 1067-75. PMID 22362515 DOI: 10.1093/Eurheartj/Ehs043  0.664
2012 Wright P, Pannell L, Nikolaev V, Lyon A, Harding S, Gorelik J. 16 Imaging Regional Differences in Beta-2 Adrenergic Receptor Function at The Cellular Level Heart. 98: A5.3-A5. DOI: 10.1136/Heartjnl-2012-302951.016  0.791
2011 Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE. SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circulation. Arrhythmia and Electrophysiology. 4: 362-72. PMID 21406682 DOI: 10.1161/Circep.110.961615  0.646
2011 Miragoli M, Moshkov A, Novak P, Shevchuk A, Nikolaev VO, El-Hamamsy I, Potter CM, Wright P, Kadir SH, Lyon AR, Mitchell JA, Chester AH, Klenerman D, Lab MJ, Korchev YE, ... Harding SE, et al. Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. Journal of the Royal Society, Interface / the Royal Society. 8: 913-25. PMID 21325316 DOI: 10.1098/Rsif.2010.0597  0.788
2011 Földes G, Mioulane M, Wright JS, Liu AQ, Novak P, Merkely B, Gorelik J, Schneider MD, Ali NN, Harding SE. Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy? Journal of Molecular and Cellular Cardiology. 50: 367-76. PMID 21047517 DOI: 10.1016/J.Yjmcc.2010.10.029  0.692
2011 Chahine MN, Mioulane M, Foldes G, Lyon A, Ali NN, Schneider MD, Harding SE. 27 Nuclear protein import mediates phenylephrine-induced hypertrophy in adult and human embryonic stem cell-derived cardiomyocytes Heart. 97. DOI: 10.1136/Heartjnl-2011-300920B.27  0.648
2010 Song W, Dyer E, Stuckey D, Leung MC, Memo M, Mansfield C, Ferenczi M, Liu K, Redwood C, Nowak K, Harding S, Clarke K, Wells D, Marston S. Investigation of a transgenic mouse model of familial dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 49: 380-9. PMID 20600154 DOI: 10.1016/J.Yjmcc.2010.05.009  0.361
2010 Stuckey DJ, Ishii H, Chen QZ, Boccaccini AR, Hansen U, Carr CA, Roether JA, Jawad H, Tyler DJ, Ali NN, Clarke K, Harding SE. Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction. Tissue Engineering. Part A. 16: 3395-402. PMID 20528670 DOI: 10.1089/ten.TEA.2010.0213  0.317
2010 Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (New York, N.Y.). 327: 1653-7. PMID 20185685 DOI: 10.1126/Science.1185988  0.821
2010 Chen QZ, Ishii H, Thouas GA, Lyon AR, Wright JS, Blaker JJ, Chrzanowski W, Boccaccini AR, Ali NN, Knowles JC, Harding SE. An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart. Biomaterials. 31: 3885-93. PMID 20153041 DOI: 10.1016/j.biomaterials.2010.01.108  0.655
2010 Sato M, Carr CA, Stuckey DJ, Ishii H, Kanda GK, Terracciano CM, Siedlecka U, Tatton L, Watt SM, Martin-Rendon E, Clarke K, Harding SE. Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy. Stem Cells and Development. 19: 1025-34. PMID 20053126 DOI: 10.1089/scd.2009.0330  0.534
2010 Lyon AR, Bannister ML, Coward E, Dubb SS, Garcia E, Kohlbrenner E, Hajjar RJ, Harding SE, Macleod KM. 011 Stabilisation of SR leak in heart failure after SERCA2A gene therapy Heart. 96: A10.1-A10. DOI: 10.1136/hrt.2010.195941.11  0.623
2009 Abdul Kadir SH, Ali NN, Mioulane M, Brito-Martins M, Abu-Hayyeh S, Foldes G, Moshkov AV, Williamson C, Harding SE, Gorelik J. Embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease. Journal of Cellular and Molecular Medicine. 13: 3730-41. PMID 19438812 DOI: 10.1111/J.1582-4934.2009.00741.X  0.69
2009 Lyon AR, MacLeod KT, Zhang Y, Garcia E, Kanda GK, Lab MJ, Korchev YE, Harding SE, Gorelik J. Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart Proceedings of the National Academy of Sciences of the United States of America. 106: 6854-6859. PMID 19342485 DOI: 10.1073/Pnas.0809777106  0.799
2008 Lyon AR, Harding SE, Peters NS. Cardiac stem cell therapy and arrhythmogenicity: prometheus and the arrows of Apollo and Artemis. Journal of Cardiovascular Translational Research. 1: 207-16. PMID 20559921 DOI: 10.1007/s12265-008-9045-x  0.637
2008 Gorelik J, Ali NN, Sheikh Abdul Kadir SH, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE. Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective. Tissue Engineering. Part C, Methods. 14: 311-8. PMID 19055357 DOI: 10.1089/Ten.Tec.2008.0058  0.672
2008 Jawad H, Lyon AR, Harding SE, Ali NN, Boccaccini AR. Myocardial tissue engineering. British Medical Bulletin. 87: 31-47. PMID 18790825 DOI: 10.1093/bmb/ldn026  0.611
2008 Siedlecka U, Arora M, Kolettis T, Soppa GK, Lee J, Stagg MA, Harding SE, Yacoub MH, Terracciano CM. Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1917-26. PMID 18775853 DOI: 10.1152/ajpheart.00258.2008  0.581
2008 Jacques AM, Briceno N, Messer AE, Gallon CE, Jalilzadeh S, Garcia E, Kikonda-Kanda G, Goddard J, Harding SE, Watkins H, Esteban MT, Tsang VT, McKenna WJ, Marston SB. The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy Cardiovascular Research. 79: 481-491. PMID 18411228 DOI: 10.1093/Cvr/Cvn094  0.381
2008 Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nature Clinical Practice. Cardiovascular Medicine. 5: 22-9. PMID 18094670 DOI: 10.1038/ncpcardio1066  0.625
2008 Lyon AR, Sato M, Hajjar RJ, Samulski RJ, Harding SE. Gene therapy: Targeting the myocardium Heart. 94: 89-99. PMID 18083952 DOI: 10.1136/Hrt.2007.116483  0.602
2008 Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Authors' response to “Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning” Nature Clinical Practice Cardiovascular Medicine. 5: E2-E2. DOI: 10.1038/ncpcardio1236  0.607
2008 Kadir SHSA, Ali NN, Abu-Hayyeh S, Harding SE, Williamson C, Gorelik J. The use of embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease Journal of Molecular and Cellular Cardiology. 44: 774. DOI: 10.1016/J.Yjmcc.2008.02.151  0.668
2008 Garcia EA, Kanda GK, Lyon A, Gallon CE, Messer AE, O'Gara P, Marston SB, Harding SE. Tonic support of contraction involving the PI3 kinase pathway in ventricular myocytes from failing human heart Journal of Molecular and Cellular Cardiology. 44: 752-753. DOI: 10.1016/J.Yjmcc.2008.02.100  0.641
2008 Lyon A, Gorelik J, Dubb S, Macleod K, Poole-Wilson P, Harding S. Surface morphology and calcium control in myocytes from a rat MI model of heart failure Journal of Molecular and Cellular Cardiology. 44: 750. DOI: 10.1016/J.Yjmcc.2008.02.094  0.796
2008 Lyon A, Sepehripour A, Dubb S, Macleod K, Poole-Wilson P, Peters N, Harding S. Heterogeneous SERCA2a transfection reduces ventricular arrhythmias in the rat model of heart failure Journal of Molecular and Cellular Cardiology. 44: 714-715. DOI: 10.1016/J.Yjmcc.2008.02.010  0.687
2008 Chen QZ, Harding SE, Ali NN, Lyon AR, Boccaccini AR. Biomaterials in cardiac tissue engineering: Ten years of research survey Materials Science and Engineering R: Reports. 59: 1-37. DOI: 10.1016/j.mser.2007.08.001  0.592
2007 Jawad H, Ali NN, Lyon AR, Chen QZ, Harding SE, Boccaccini AR. Myocardial tissue engineering: a review. Journal of Tissue Engineering and Regenerative Medicine. 1: 327-42. PMID 18038427 DOI: 10.1002/term.46  0.626
2007 Patel TA, Belcher E, Warner TD, Harding SE, Mitchell JA. Identification and characterization of a dysfunctional cardiac myocyte phenotype: Role of bacteria, toll-like receptors, and endothelin Shock. 28: 434-440. PMID 17558348 DOI: 10.1097/shk.0b013e31804a55a7  0.316
2007 Lyon A, Harding S. The potential of cardiac stem cell therapy for heart failure. Current Opinion in Pharmacology. 7: 164-70. PMID 17275411 DOI: 10.1016/J.Coph.2006.10.003  0.69
2007 Harding SE, Ali NN, Brito-Martins M, Gorelik J. The human embryonic stem cell-derived cardiomyocyte as a pharmacological model Pharmacology and Therapeutics. 113: 341-353. PMID 17081613 DOI: 10.1016/J.Pharmthera.2006.08.008  0.694
2007 Gorelik J, Yang L, Zhang Y, Lab M, Korchev YE, Monte Fd, Harding SE. WITHDRAWN: A novel Z-groove index characterizing myocardial surface structure and its modification in failing human heart Journal of Molecular and Cellular Cardiology. 42. DOI: 10.1016/J.Yjmcc.2007.03.812  0.703
2007 Lyon AR, Poole-Wilson PA, Peters NS, Harding SE. Differential effects of SERCA2a transfection on ventricular arrhythmia susceptibility in the normal rat heart Journal of Molecular and Cellular Cardiology. 42: S20. DOI: 10.1016/J.YJMCC.2007.03.056  0.659
2006 Gorelik J, Yang LQ, Zhang Y, Lab M, Korchev Y, Harding SE. A novel Z-groove index characterizing myocardial surface structure Cardiovascular Research. 72: 422-429. PMID 17054929 DOI: 10.1016/J.Cardiores.2006.09.009  0.683
2006 Gorelik J, Ali NN, Shevchuk AI, Lab M, Williamson C, Harding SE, Korchev YE. Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy Tissue Engineering. 12: 657-664. PMID 16674281 DOI: 10.1089/Ten.2006.12.657  0.688
2006 Yang LQ, Gorelik J, Korchev Y, Harding SE. Increase in β1AR-Gi coupling after detubulation in rat ventricular myocytes Journal of Molecular and Cellular Cardiology. 40: 923-924. DOI: 10.1016/J.Yjmcc.2006.03.025  0.678
2005 Ali NN, Brito-Martins M, Gorelik J, Xu X, Korchev Y, Zhu H, Poole-Wilson PA, Fuller SJ, Harding SE. Pharmacological characterisation of embryonic stem cell-derived cardiomyocyte cultures Stem Cell Repair and Regeneration. 139-148. DOI: 10.1142/9781860949296_0010  0.665
2003 Terracciano CM, Harding SE, Adamson D, Koban M, Tansley P, Birks EJ, Barton PJ, Yacoub MH. Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy. European Heart Journal. 24: 1329-39. PMID 12871690 DOI: 10.1016/S0195-668X(03)00242-2  0.574
2003 Rau T, Nose M, Remmers U, Weil J, Weissmüller A, Davia K, Harding S, Peppel K, Koch WJ, Eschenhagen T. Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 523-5. PMID 12631586 DOI: 10.1096/Fj.02-0660Fje  0.405
2003 El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann WH, Jäckel E, Harding SE, Boknik P, Neumann J, Eschenhagen T. Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 437-9. PMID 12514122 DOI: 10.1096/fj.02-0057fje  0.307
2003 Terracciano CM, Hajjar RJ, Harding SE. Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes. Cell Calcium. 31: 299-305. PMID 12098219 DOI: 10.1016/S0143-4160(02)00058-1  0.511
2002 Gorelik J, Gu Y, Spohr HA, Shevchuk AI, Lab MJ, Harding SE, Edwards CR, Whitaker M, Moss GW, Benton DC, Sánchez D, Darszon A, Vodyanoy I, Klenerman D, Korchev YE. Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophysical Journal. 83: 3296-303. PMID 12496097 DOI: 10.1016/S0006-3495(02)75330-7  0.663
2002 Gorelik J, Harding SE, Shevchuk AI, Koralage D, Lab M, de Swiet M, Korchev Y, Williamson C. Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clinical Science (London, England : 1979). 103: 191-200. PMID 12149111 DOI: 10.1042/Cs1030191  0.691
2002 Ranu HK, Terracciano CM, Davia K, Bernobich E, Chaudhri B, Robinson SE, Bin Kang Z, Hajjar RJ, MacLeod KT, Harding SE. Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 34: 389-400. PMID 11991729 DOI: 10.1006/Jmcc.2001.1521  0.511
2002 Gu Y, Gorelik J, Spohr HA, Shevchuk A, Lab MJ, Harding SE, Vodyanoy I, Klenerman D, Korchev YE. High-resolution scanning patch-clamp: new insights into cell function The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 748-750. PMID 11923226 DOI: 10.1096/Fj.01-1024Fje  0.673
2001 Shevchuk AI, Gorelik J, Harding SE, Lab MJ, Klenerman D, Korchev YE. Simultaneous measurement of Ca2+ and cellular dynamics: Combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes Biophysical Journal. 81: 1759-1764. PMID 11509385 DOI: 10.1016/S0006-3495(01)75826-2  0.705
2001 Davia K, Bernobich E, Ranu HK, del Monte F, Terracciano CM, MacLeod KT, Adamson DL, Chaudhri B, Hajjar RJ, Harding SE. SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 33: 1005-15. PMID 11343422 DOI: 10.1006/Jmcc.2001.1368  0.545
1999 Owen VJ, Burton PB, Michel MC, Zolk O, Böhm M, Pepper JR, Barton PJ, Yacoub MH, Harding SE. Myocardial dysfunction in donor hearts. A possible etiology. Circulation. 99: 2565-70. PMID 10330389 DOI: 10.1161/01.CIR.99.19.2565  0.301
1999 Monte Fd, Harding S, Gwathmey JK, Rosenzweig A, Hajjar RJ. Restoration of contractile function in isolated failing human ventricular cardiac myocytes by gene transfer of SERCA2a Journal of Cardiac Failure. 5: 1. DOI: 10.1016/S1071-9164(99)91346-5  0.383
1996 Lefroy DC, Crake T, Monte FD, Vescovo G, Libera LD, Harding S, Poole-Wilson PA. Angiotensin II and contraction of isolated myocytes from human, guinea pig, and infarcted rat hearts American Journal of Physiology-Heart and Circulatory Physiology. 270. PMID 8764257 DOI: 10.1152/Ajpheart.1996.270.6.H2060  0.353
1996 Ravens U, Davia K, Davies CH, O'Gara P, Drake-Holland AJ, Hynd JW, Noble MIM, Harding SE. Tachycardia-induced failure alters contractile properties of canine ventricular myocytes Cardiovascular Research. 32: 613-621. DOI: 10.1016/S0008-6363(96)00121-6  0.332
1995 Harding SE, MacLeod KT, Davies CH, Wynne DG, Poole-Wilson PA. Abnormalities of the myocytes in ischaemic cardiomyopathy. European Heart Journal. 16: 74-81. PMID 8829961 DOI: 10.1093/Eurheartj/16.Suppl_I.74  0.376
1995 Davies C, Poole-Wilson P, Harding S. Does Reduced Contraction of Individual Ventricular Myocytes Contribute to the Pathogenesis of Human Heart Failure Clinical Science. 89. DOI: 10.1042/Cs089046P  0.393
1994 Harding SE, Davies CH, Wynne DG, Poole-Wilson PA. Contractile function and response to agonists in myocytes from failing human heart. European Heart Journal. 15: 35-6. PMID 7713111 DOI: 10.1093/EURHEARTJ/15.SUPPL_D.35  0.315
1989 Poole-Wilson P, Harding S, O'Gara P, Jones S. Comparison of Isolated Atrial and Ventricular Myocytes from Humans and Rabbits Clinical Science. 76. DOI: 10.1042/Cs076006P  0.305
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