Frank Reimann - Publications

Clinical Biochemistry University of Cambridge, Cambridge, England, United Kingdom 

201 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr]apelin-13 in humans. Scientific Reports. 9: 19934. PMID 31882594 DOI: 10.1038/s41598-019-56157-9  1
2019 Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, ... ... Reimann F, et al. GDF15 mediates the effects of metformin on body weight and energy balance. Nature. PMID 31875646 DOI: 10.1038/s41586-019-1911-y  1
2019 Reimann F, Diakogiannaki E, E Moss C, Gribble FM. Cellular mechanisms governing Glucose-dependent insulinotropic polypeptide secretion. Peptides. 170206. PMID 31756367 DOI: 10.1016/j.peptides.2019.170206  1
2019 Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fändriks L. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet. Gut. PMID 31753852 DOI: 10.1136/gutjnl-2019-319372  1
2019 Sarnobat D, Moffett RC, Gault VA, Tanday N, Reimann F, Gribble FM, Flatt PR, Irwin N. Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic Glu;ROSA26-eYFP mice. Peptides. 170205. PMID 31738969 DOI: 10.1016/j.peptides.2019.170205  1
2019 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Molecular Metabolism. 29: 158-169. PMID 31668387 DOI: 10.1016/j.molmet.2019.09.001  1
2019 Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O'Rahilly S, ... ... Reimann F, et al. Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion. Scientific Reports. 9: 15574. PMID 31666564 DOI: 10.1038/s41598-019-52049-0  1
2019 Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31666353 DOI: 10.1523/JNEUROSCI.2145-19.2019  1
2019 Thiebaud N, Gribble F, Reimann F, Trapp S, Fadool DA. A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Scientific Reports. 9: 15542. PMID 31664163 DOI: 10.1038/s41598-019-51880-9  0.68
2019 Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE. Ghrelin does not directly stimulate secretion of glucagon-like peptide-1. The Journal of Clinical Endocrinology and Metabolism. PMID 31608930 DOI: 10.1210/clinem/dgz046  1
2019 Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. International Journal of Molecular Sciences. 20. PMID 31509948 DOI: 10.3390/ijms20184448  1
2019 Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, et al. Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 31503512 DOI: 10.1152/ajpendo.00239.2019  1
2019 Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metabolism. PMID 31447324 DOI: 10.1016/j.cmet.2019.07.013  1
2019 Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q. Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca release. The Journal of General Physiology. PMID 31358556 DOI: 10.1085/jgp.201912351  0.32
2019 Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, et al. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Obesity (Silver Spring, Md.). 27: 1292-1304. PMID 31338999 DOI: 10.1002/oby.22521  0.48
2019 Terrill SJ, Holt MK, Maske CB, Abrams N, Reimann F, Trapp S, Williams DL. Endogenous GLP-1 in lateral septum promotes satiety and suppresses motivation for food in mice. Physiology & Behavior. PMID 30980855 DOI: 10.1016/j.physbeh.2019.04.008  0.68
2019 Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. No direct effect of SGLT2 activity on glucagon secretion. Diabetologia. PMID 30903205 DOI: 10.1007/s00125-019-4849-6  1
2019 Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nature Communications. 10: 1029. PMID 30833673 DOI: 10.1038/s41467-019-09045-9  1
2019 Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nature Reviews. Endocrinology. PMID 30760847 DOI: 10.1038/s41574-019-0168-8  1
2019 Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, ... Reimann F, et al. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. PMID 30733330 DOI: 10.2337/db18-0883  1
2019 Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. The Journal of Clinical Endocrinology and Metabolism. PMID 30726969 DOI: 10.1210/jc.2018-02503  1
2019 Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Reports. 26: 1399-1408.e6. PMID 30726726 DOI: 10.1016/j.celrep.2019.01.047  1
2019 Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, ... ... Reimann F, et al. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metabolism. PMID 30639358 DOI: 10.1016/j.cmet.2018.12.016  1
2019 Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, et al. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature Communications. 10: 139. PMID 30635569 DOI: 10.1038/s41467-018-08193-8  1
2018 Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N. Butyrate Produced by Commensal Bacteria Down-Regulates () Expression a Dual Mechanism in Human Intestinal Epithelial Cells. Frontiers in Immunology. 9: 2838. PMID 30619249 DOI: 10.3389/fimmu.2018.02838  0.48
2018 Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, et al. Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Therapy. PMID 30514969 DOI: 10.1038/s41434-018-0052-5  1
2018 Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O'Rahilly S, et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 564: 263-267. PMID 30487605 DOI: 10.1038/s41586-018-0753-3  1
2018 Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, et al. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Molecular Metabolism. PMID 30472415 DOI: 10.1016/j.molmet.2018.10.012  0.48
2018 Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes. PMID 30279161 DOI: 10.2337/db18-0729  1
2018 Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. PMID 30239642 DOI: 10.1210/en.2018-00672  1
2018 Adriaenssens AE, Reimann F, Gribble FM. Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract. Comprehensive Physiology. 8: 1603-1638. PMID 30215862 DOI: 10.1002/cphy.c170047  1
2018 Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Molecular Metabolism. PMID 30201275 DOI: 10.1016/j.molmet.2018.08.006  1
2018 Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F. Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Molecular Metabolism. PMID 30104166 DOI: 10.1016/j.molmet.2018.07.011  1
2018 Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, et al. Assessment and Management of Anti-insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome. The Journal of Clinical Endocrinology and Metabolism. PMID 30085133 DOI: 10.1210/jc.2018-00972  1
2018 Tarasov AI, Galvanovskis J, Rorsman O, Hamilton A, Vergari E, Johnson PRV, Reimann F, Ashcroft FM, Rorsman P. Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis. Lab On a Chip. PMID 30083680 DOI: 10.1039/c8lc00417j  0.72
2018 Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient. Nature Cell Biology. PMID 30038251 DOI: 10.1038/s41556-018-0143-y  0.4
2018 Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM. Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours. Rapid Communications in Mass Spectrometry : Rcm. PMID 29857350 DOI: 10.1002/rcm.8183  1
2018 Lu VB, Gribble FM, Reimann F. Free-fatty acid receptors in enteroendocrine cells. Endocrinology. PMID 29688303 DOI: 10.1210/en.2018-00261  1
2018 Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Molecular Metabolism. PMID 29656109 DOI: 10.1016/j.molmet.2018.03.007  1
2018 Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM. Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. PMID 29548882 DOI: 10.1016/j.soard.2018.01.039  1
2018 Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Molecular Metabolism. PMID 29439854 DOI: 10.1016/j.molmet.2018.01.021  1
2018 Gribble FM, Meek CL, Reimann F. Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies. Peptides. 100: 68-74. PMID 29412834 DOI: 10.1016/j.peptides.2017.11.008  1
2018 Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F. Microbial regulation of the L cell transcriptome. Scientific Reports. 8: 1207. PMID 29352262 DOI: 10.1038/s41598-017-18079-2  1
2017 Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells. Molecular Metabolism. PMID 29167062 DOI: 10.1016/j.molmet.2017.11.005  1
2017 Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM. Development and characterisation of a novel glucagon like peptide-1 receptor antibody. Diabetologia. PMID 29119245 DOI: 10.1007/s00125-017-4491-0  1
2017 Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM. Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine. Molecular Metabolism. 6: 1296-1303. PMID 29031728 DOI: 10.1016/j.molmet.2017.07.014  1
2017 Chimerel C, Riccio C, Murison K, Gribble FM, Reimann F. Optogenetic analysis of depolarization dependent glucagon-like peptide-1 release. Endocrinology. PMID 28938466 DOI: 10.1210/en.2017-00434  1
2017 Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F. Chylomicrons stimulate incretin secretion in mouse and human cells. Diabetologia. PMID 28866808 DOI: 10.1007/s00125-017-4420-2  1
2017 Holt MK, Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S. Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse. Molecular Metabolism. 6: 909-921. PMID 28752054 DOI: 10.1016/j.molmet.2017.06.002  1
2017 Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. PMID 28636871 DOI: 10.1016/j.steroids.2017.06.005  1
2017 Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. PMID 28596237 DOI: 10.2337/db16-1403  1
2017 Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. Journal of Visualized Experiments : Jove. PMID 28448057 DOI: 10.3791/55687  1
2017 Gribble FM, Reimann F. Signalling in the gut endocrine axis. Physiology & Behavior. PMID 28257936 DOI: 10.1016/j.physbeh.2017.02.039  1
2017 Anderberg RH, Richard JE, Eerola K, Ferreras LL, Nordbeck EB, Hansson C, Nissbrandt H, Berqquist F, Gribble FM, Reimann F, Wernstedt-Asterholm I, Lamy C, Skibicka KP. Glucagon-Like Peptide-1 and its Analogues Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight. Diabetes. PMID 28057699 DOI: 10.2337/db16-0755  1
2017 Biggs EK, Gribble FM, Reimann F. Scaling it down: new in vitro tools to get the balance right. The Biochemical Journal. 474: 47-50. PMID 28008090 DOI: 10.1042/BCJ20160874  1
2016 Gribble FM, Diakogiannaki E, Reimann F. Gut Hormone Regulation and Secretion via FFA1 and FFA4. Handbook of Experimental Pharmacology. PMID 27873089 DOI: 10.1007/164_2016_46  1
2016 Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor dependent GLP-1 and PYY secretion in mice and humans. Endocrinology. en20161384. PMID 27447725 DOI: 10.1210/en.2016-1384  0.68
2016 Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia. PMID 27390011 DOI: 10.1007/s00125-016-4033-1  1
2016 Reimann F, Gribble FM. Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion. Journal of Diabetes Investigation. 7: 13-9. PMID 27186350 DOI: 10.1111/jdi.12478  1
2016 Anesten FB, Holt MK, Schéle E, Palsdottir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon (PPG) neurons in the hindbrain have IL-6 Receptor α (IL-6Rα) and show Ca2+ influx in response to IL-6. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00383.2015. PMID 27097661 DOI: 10.1152/ajpregu.00383.2015  1
2016 Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in Arginine Vasopressin - mediated inhibition of colonic anion secretion. The Journal of Physiology. PMID 27037495 DOI: 10.1113/JP272053  0.68
2016 Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA. Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. Plos One. 11: e0149549. PMID 27010458 DOI: 10.1371/journal.pone.0149549  1
2016 Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA. The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. The Journal of Physiology. PMID 26931093 DOI: 10.1113/JP272322  0.68
2016 Pais R, Gribble FM, Reimann F. Stimulation of incretin secreting cells. Therapeutic Advances in Endocrinology and Metabolism. 7: 24-42. PMID 26885360 DOI: 10.1177/2042018815618177  1
2016 Kuhre RE, Wewer Albrechtsen NJ, Deacon C, Balk-Møller E, Rehfeld JF, Reimann F, Gribble F, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells. Journal of Molecular Endocrinology. PMID 26819328 DOI: 10.1530/JME-15-0293  0.48
2016 Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin Endocrinology. 157: 536-547. DOI: 10.1210/en.2015-1725  1
2016 Reimann F, Gribble FM. Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion Journal of Diabetes Investigation. DOI: 10.1111/jdi.12478  1
2015 Reimann F, Gribble FM. G protein-coupled receptors as new therapeutic targets for type 2 diabetes. Diabetologia. PMID 26661410 DOI: 10.1007/s00125-015-3825-z  1
2015 Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. British Journal of Pharmacology. PMID 26661062 DOI: 10.1111/bph.13407  1
2015 Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides. PMID 26541888 DOI: 10.1016/j.peptides.2015.10.008  1
2015 Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Molecular Metabolism. 4: 718-31. PMID 26500843 DOI: 10.1016/j.molmet.2015.07.008  1
2015 Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Habib A, Egerod KL, Jensen SM, Gribble F, Schwartz TW, Reimann F, Holst JJ. GLP1 and GIP cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. The Journal of Endocrinology. PMID 26483393 DOI: 10.1530/JOE-15-0247  1
2015 Gribble FM, Reimann F. Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium. Annual Review of Physiology. PMID 26442437 DOI: 10.1146/annurev-physiol-021115-105439  1
2015 Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA. Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells. Molecular Metabolism. 4: 619-30. PMID 26413468 DOI: 10.1016/j.molmet.2015.06.007  1
2015 Meek CL, Lewis HB, Reimann F, Gribble FM, Park AJ. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides. PMID 26344355 DOI: 10.1016/j.peptides.2015.08.013  1
2015 Meek CL, Reimann F, Park AJ, Gribble FM. Can encapsulated glutamine increase GLP-1 secretion, improve glucose tolerance, and reduce meal size in healthy volunteers? A randomised, placebo-controlled, cross-over trial. Lancet (London, England). 385: S68. PMID 26312890 DOI: 10.1016/S0140-6736(15)60383-X  1
2015 Brighton CA, Rievaj J, Kuhre RE, Glass LL, Schoonjans K, Holst JJ, Gribble FM, Reimann F. Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology. 156: 3961-70. PMID 26280129 DOI: 10.1210/en.2015-1321  1
2015 Adriaenssens A, Lam BY, Billing L, Skeffington K, Sewing S, Reimann F, Gribble F. A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology. 156: 3924-36. PMID 26241122 DOI: 10.1210/en.2015-1301  1
2015 Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides. PMID 26215048 DOI: 10.1016/j.peptides.2015.07.019  1
2015 Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides. PMID 26145551 DOI: 10.1016/j.peptides.2015.06.006  1
2015 Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides. PMID 26144594 DOI: 10.1016/j.peptides.2015.06.012  1
2015 Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, ... ... Reimann F, et al. Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nature Communications. 6: 7629. PMID 26134028 DOI: 10.1038/ncomms8629  1
2015 Lewis HB, Ahern AL, Solis-Trapala I, Walker CG, Reimann F, Gribble FM, Jebb SA. Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults. Obesity (Silver Spring, Md.). 23: 1362-70. PMID 26054049 DOI: 10.1002/oby.21105  1
2015 Emery EC, Habib AM, Cox JJ, Nicholas AK, Gribble FM, Woods CG, Reimann F. Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7674-81. PMID 25995458 DOI: 10.1523/JNEUROSCI.3935-14.2015  1
2015 Li J, Yu Q, Ahooghalandari P, Gribble FM, Reimann F, Tengholm A, Gylfe E. Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25911612 DOI: 10.1096/fj.14-265918  1
2015 Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, et al. LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Molecular Metabolism. 4: 277-86. PMID 25830091 DOI: 10.1016/j.molmet.2015.01.006  1
2015 Richard JE, Anderberg RH, Göteson A, Gribble FM, Reimann F, Skibicka KP. Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system. Plos One. 10: e0119034. PMID 25793511 DOI: 10.1371/journal.pone.0119034  1
2015 Stamenkovic JA, Andersson LE, Adriaenssens AE, Bagge A, Sharoyko VV, Gribble F, Reimann F, Wollheim CB, Mulder H, Spégel P. Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion. The Biochemical Journal. 468: 49-63. PMID 25731850 DOI: 10.1042/BJ20140697  1
2015 Psichas A, Reimann F, Gribble FM. Gut chemosensing mechanisms. The Journal of Clinical Investigation. 125: 908-17. PMID 25664852 DOI: 10.1172/JCI76309  1
2015 Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ. Targeting development of incretin-producing cells increases insulin secretion. The Journal of Clinical Investigation. 125: 379-85. PMID 25500886 DOI: 10.1172/JCI75838  1
2015 Llewellyn-Smith IJ, Marina N, Manton RN, Reimann F, Gribble FM, Trapp S. Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons. Neuroscience. 284: 872-87. PMID 25450967 DOI: 10.1016/j.neuroscience.2014.10.043  1
2015 Emery EC, Diakogiannaki E, Gentry C, Psichas A, Habib AM, Bevan S, Fischer MJ, Reimann F, Gribble FM. Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1. Diabetes. 64: 1202-10. PMID 25325736 DOI: 10.2337/db14-0737  1
2015 Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain Molecular Metabolism. DOI: 10.1016/j.molmet.2015.07.008  1
2015 Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA. Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells Molecular Metabolism. 4: 619-630. DOI: 10.1016/j.molmet.2015.06.007  1
2014 Chimerel C, Emery E, Summers DK, Keyser U, Gribble FM, Reimann F. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Reports. 9: 1202-8. PMID 25456122 DOI: 10.1016/j.celrep.2014.10.032  1
2014 Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metabolism. 20: 1018-29. PMID 25453189 DOI: 10.1016/j.cmet.2014.10.004  1
2014 Reimann F, Reddy AB. Clocking up GLP-1: considering intestinal rhythms in the incretin effect. Diabetes. 63: 3584-6. PMID 25342730 DOI: 10.2337/db14-0781  1
2014 Parker HE, Gribble FM, Reimann F. The role of gut endocrine cells in control of metabolism and appetite. Experimental Physiology. 99: 1116-20. PMID 25210110 DOI: 10.1113/expphysiol.2014.079764  1
2014 Zac-Varghese S, Trapp S, Richards P, Sayers S, Sun G, Bloom SR, Reimann F, Gribble FM, Rutter GA. The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Disease Models & Mechanisms. 7: 1275-86. PMID 25190708 DOI: 10.1242/dmm.014720  1
2014 Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of Physiology. 592: 4677-96. PMID 25172946 DOI: 10.1113/jphysiol.2014.274209  1
2014 Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature Communications. 5: 4639. PMID 25145789 DOI: 10.1038/ncomms5639  1
2014 Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature. 514: 503-7. PMID 25141178 DOI: 10.1038/nature13633  1
2014 Richard JE, Farkas I, Anesten F, Anderberg RH, Dickson SL, Gribble FM, Reimann F, Jansson JO, Liposits Z, Skibicka KP. GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence. Endocrinology. 155: 4356-67. PMID 25116706 DOI: 10.1210/en.2014-1248  1
2014 Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4972-85. PMID 25070369 DOI: 10.1096/fj.14-257667  1
2014 Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, ... ... Reimann F, et al. Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proceedings of the National Academy of Sciences of the United States of America. 111: 11133-8. PMID 25028498 DOI: 10.1073/pnas.1411413111  0.48
2014 Kuhre RE, Gribble FM, Hartmann B, Reimann F, Windeløv JA, Rehfeld JF, Holst JJ. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G622-30. PMID 24525020 DOI: 10.1152/ajpgi.00372.2013  0.48
2014 Richards P, Parker HE, Adriaenssens AE, Hodgson JM, Cork SC, Trapp S, Gribble FM, Reimann F. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes. 63: 1224-33. PMID 24296712 DOI: 10.2337/db13-1440  1
2014 Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ. Generation of L cells in mouse and human small intestine organoids. Diabetes. 63: 410-20. PMID 24130334 DOI: 10.2337/db13-0991  1
2013 Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, ... ... Reimann F, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metabolism. 18: 871-82. PMID 24315372 DOI: 10.1016/j.cmet.2013.10.014  1
2013 Reimann F, Gribble FM. Towards the harnessing of gut feelings. Current Opinion in Pharmacology. 13: 909-11. PMID 24140240 DOI: 10.1016/j.coph.2013.09.020  1
2013 Reimann F, Gribble FM. A tag to track short chain fatty acid sensors. Endocrinology. 154: 3492-4. PMID 24058154 DOI: 10.1210/en.2013-1789  1
2013 Diakogiannaki E, Pais R, Tolhurst G, Parker HE, Horscroft J, Rauscher B, Zietek T, Daniel H, Gribble FM, Reimann F. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 56: 2688-96. PMID 24045836 DOI: 10.1007/s00125-013-3037-3  1
2013 Ezcurra M, Reimann F, Gribble FM, Emery E. Molecular mechanisms of incretin hormone secretion. Current Opinion in Pharmacology. 13: 922-7. PMID 24035446 DOI: 10.1016/j.coph.2013.08.013  1
2013 Habib AM, Richards P, Rogers GJ, Reimann F, Gribble FM. Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia. 56: 1413-6. PMID 23519462 DOI: 10.1007/s00125-013-2887-z  1
2013 Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T. The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. The Journal of Biological Chemistry. 288: 4513-21. PMID 23269670 DOI: 10.1074/jbc.M112.402677  1
2013 Llewellyn-Smith IJ, Gnanamanickam GJ, Reimann F, Gribble FM, Trapp S. Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience. 229: 130-43. PMID 23069752 DOI: 10.1016/j.neuroscience.2012.09.071  1
2012 Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, et al. PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. The Journal of Clinical Investigation. 122: 4105-17. PMID 23093780 DOI: 10.1172/JCI42127  1
2012 Moss CE, Marsh WJ, Parker HE, Ogunnowo-Bada E, Riches CH, Habib AM, Evans ML, Gribble FM, Reimann F. Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents. Diabetologia. 55: 3094-103. PMID 22872212 DOI: 10.1007/s00125-012-2663-5  1
2012 Garfield AS, Patterson C, Skora S, Gribble FM, Reimann F, Evans ML, Myers MG, Heisler LK. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology. 153: 4600-7. PMID 22869346 DOI: 10.1210/en.2012-1282  1
2012 Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F, Gribble FM. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology. 153: 3054-65. PMID 22685263 DOI: 10.1210/en.2011-2170  1
2012 Parker HE, Adriaenssens A, Rogers G, Richards P, Koepsell H, Reimann F, Gribble FM. Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia. 55: 2445-55. PMID 22638549 DOI: 10.1007/s00125-012-2585-2  1
2012 Reimann F, Tolhurst G, Gribble FM. G-protein-coupled receptors in intestinal chemosensation. Cell Metabolism. 15: 421-31. PMID 22482725 DOI: 10.1016/j.cmet.2011.12.019  1
2012 Tolhurst G, Reimann F, Gribble FM. Intestinal sensing of nutrients. Handbook of Experimental Pharmacology. 309-35. PMID 22249821 DOI: 10.1007/978-3-642-24716-3_14  1
2012 Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J, Reimann F, Gribble FM. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 61: 364-71. PMID 22190648 DOI: 10.2337/db11-1019  1
2012 Diakogiannaki E, Gribble FM, Reimann F. Nutrient detection by incretin hormone secreting cells. Physiology & Behavior. 106: 387-93. PMID 22182802 DOI: 10.1016/j.physbeh.2011.12.001  1
2012 Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, ... ... Reimann F, et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 61: 187-96. PMID 22124465 DOI: 10.2337/db11-1029  1
2012 Parker HE, Wallis K, le Roux CW, Wong KY, Reimann F, Gribble FM. Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. British Journal of Pharmacology. 165: 414-23. PMID 21718300 DOI: 10.1111/j.1476-5381.2011.01561.x  1
2011 Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature Medicine. 17: 1481-9. PMID 22037645 DOI: 10.1038/nm.2513  1
2011 Hisadome K, Reimann F, Gribble FM, Trapp S. CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 60: 2701-9. PMID 21885869 DOI: 10.2337/db11-0489  1
2011 Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S. Preproglucagon neurons project widely to autonomic control areas in the mouse brain. Neuroscience. 180: 111-21. PMID 21329743 DOI: 10.1016/j.neuroscience.2011.02.023  1
2011 Rogers GJ, Tolhurst G, Ramzan A, Habib AM, Parker HE, Gribble FM, Reimann F. Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells. The Journal of Physiology. 589: 1081-93. PMID 21224236 DOI: 10.1113/jphysiol.2010.198069  1
2011 Tolhurst G, Zheng Y, Parker HE, Habib AM, Reimann F, Gribble FM. Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP. Endocrinology. 152: 405-13. PMID 21209017 DOI: 10.1210/en.2010-0956  1
2011 da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, Bugliani M, Marselli L, Marchetti P, Birzele F, Sun G, Scharfmann R, Rutter J, Siniakowicz K, Weir G, ... ... Reimann F, et al. Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 54: 819-27. PMID 21181396 DOI: 10.1007/s00125-010-2010-7  1
2011 Friedlander RS, Moss CE, Mace J, Parker HE, Tolhurst G, Habib AM, Wachten S, Cooper DM, Gribble FM, Reimann F. Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells. British Journal of Pharmacology. 163: 261-71. PMID 21054345 DOI: 10.1111/j.1476-5381.2010.01107.x  1
2010 Cox JJ, Sheynin J, Shorer Z, Reimann F, Nicholas AK, Zubovic L, Baralle M, Wraige E, Manor E, Levy J, Woods CG, Parvari R. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Human Mutation. 31: E1670-86. PMID 20635406 DOI: 10.1002/humu.21325  1
2010 Hisadome K, Reimann F, Gribble FM, Trapp S. Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons. Diabetes. 59: 1890-8. PMID 20522593 DOI: 10.2337/db10-0128  1
2010 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, et al. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metabolism. 11: 543-53. PMID 20519125 DOI: 10.1016/j.cmet.2010.04.007  1
2010 Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, et al. Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 53: 924-36. PMID 20221584 DOI: 10.1007/s00125-010-1692-1  1
2010 Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin DV, McHale DP, Drenth JP, Dai F, Wheeler J, Sanders F, Wood L, Wu TX, Karppinen J, Nikolajsen L, Männikkö M, et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proceedings of the National Academy of Sciences of the United States of America. 107: 5148-53. PMID 20212137 DOI: 10.1073/pnas.0913181107  1
2010 Reimann F. Molecular mechanisms underlying nutrient detection by incretin-secreting cells. International Dairy Journal / Published in Association With the International Dairy Federation. 20: 236-242. PMID 20204054 DOI: 10.1016/j.idairyj.2009.11.014  1
2010 Parker HE, Reimann F, Gribble FM. Molecular mechanisms underlying nutrient-stimulated incretin secretion. Expert Reviews in Molecular Medicine. 12: e1. PMID 20047700 DOI: 10.1017/S146239940900132X  1
2009 Guran T, Tolhurst G, Bereket A, Rocha N, Porter K, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, et al. Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. The Journal of Clinical Endocrinology and Metabolism. 94: 3633-9. PMID 19755480 DOI: 10.1210/jc.2009-0551  1
2009 Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, ... ... Reimann F, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 58: 2070-83. PMID 19542200 DOI: 10.2337/db09-0551  1
2009 Ong WK, Gribble FM, Reimann F, Lynch MJ, Houslay MD, Baillie GS, Furman BL, Pyne NJ. The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. British Journal of Pharmacology. 157: 633-44. PMID 19371330 DOI: 10.1111/j.1476-5381.2009.00194.x  1
2009 Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia. 52: 289-98. PMID 19082577 DOI: 10.1007/s00125-008-1202-x  1
2009 Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O'Rahilly S, Semple RK. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nature Genetics. 41: 354-8. PMID 19079066 DOI: 10.1038/ng.306  1
2009 Greenfield JR, Farooqi IS, Keogh JM, Henning E, Habib AM, Blackwood A, Reimann F, Holst JJ, Gribble FM. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. The American Journal of Clinical Nutrition. 89: 106-13. PMID 19056578 DOI: 10.3945/ajcn.2008.26362  1
2009 Tolhurst G, Reimann F, Gribble FM. Nutritional regulation of glucagon-like peptide-1 secretion. The Journal of Physiology. 587: 27-32. PMID 19001044 DOI: 10.1113/jphysiol.2008.164012  1
2009 Gonzàlez JA, Reimann F, Burdakov D. Dissociation between sensing and metabolism of glucose in sugar sensing neurones. The Journal of Physiology. 587: 41-8. PMID 18981030 DOI: 10.1113/jphysiol.2008.163410  0.48
2008 Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM. Glucose sensing in L cells: a primary cell study. Cell Metabolism. 8: 532-9. PMID 19041768 DOI: 10.1016/j.cmet.2008.11.002  1
2008 Casas S, Novials A, Reimann F, Gomis R, Gribble FM. Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia. 51: 2252-62. PMID 18751967 DOI: 10.1007/s00125-008-1111-z  1
2008 Evans JM, Ogston SA, Reimann F, Gribble FM, Morris AD, Pearson ER. No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis. Diabetes, Obesity & Metabolism. 10: 350-2. PMID 18093208 DOI: 10.1111/j.1463-1326.2007.00833.x  1
2007 Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, Reimann F, Gribble FM. Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line. Diabetologia. 50: 2181-9. PMID 17643200 DOI: 10.1007/s00125-007-0750-9  0.48
2006 Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 444: 894-8. PMID 17167479 DOI: 10.1038/nature05413  1
2006 O'Malley D, Reimann F, Simpson AK, Gribble FM. Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes. 55: 3381-6. PMID 17130483 DOI: 10.2337/db06-0531  1
2006 Pryor PR, Reimann F, Gribble FM, Luzio JP. Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (Copenhagen, Denmark). 7: 1388-98. PMID 16978393 DOI: 10.1111/j.1600-0854.2006.00475.x  1
2006 Reimann F, Ward PS, Gribble FM. Signaling mechanisms underlying the release of glucagon-like peptide 1 Diabetes. 55: S78-S85. DOI: 10.2337/db06-S010  1
2005 Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, Simpson AK, Gribble FM. The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line. The Journal of Physiology. 569: 761-72. PMID 16223757 DOI: 10.1113/jphysiol.2005.098962  0.48
2005 Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT. Relapsing diabetes can result from moderately activating mutations in KCNJ11. Human Molecular Genetics. 14: 925-34. PMID 15718250 DOI: 10.1093/hmg/ddi086  1
2005 Reimann F, Maziarz M, Flock G, Habib AM, Drucker DJ, Gribble FM. Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line. The Journal of Physiology. 563: 161-75. PMID 15611035 DOI: 10.1113/jphysiol.2004.076414  0.48
2004 Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM. Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia. 47: 1592-601. PMID 15365617 DOI: 10.1007/s00125-004-1498-0  1
2004 Gärtner U, Alpár A, Reimann F, Seeger G, Heumann R, Arendt T. Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice. Journal of Neuroscience Research. 77: 630-41. PMID 15352209 DOI: 10.1002/jnr.20194  1
2004 Gribble FM, Reimann F. Open to control--new hope for patients with neonatal diabetes. The New England Journal of Medicine. 350: 1817-8. PMID 15115828 DOI: 10.1056/NEJMp048044  1
2004 Bartsch S, Brüning A, Reimann FM, Ludwig D. Haemodynamic effects of dopexamine on postprandial splanchnic hyperaemia. European Journal of Clinical Investigation. 34: 268-74. PMID 15086358 DOI: 10.1111/j.1365-2362.2004.01323.x  1
2004 Rungroj N, Devonald MA, Cuthbert AW, Reimann F, Akkarapatumwong V, Yenchitsomanus PT, Bennett WM, Karet FE. A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells. The Journal of Biological Chemistry. 279: 13833-8. PMID 14734552 DOI: 10.1074/jbc.M400188200  1
2003 Gribble FM, Reimann F. Sulphonylurea action revisited: the post-cloning era. Diabetologia. 46: 875-91. PMID 12819907 DOI: 10.1007/s00125-003-1143-3  1
2003 Gribble FM, Williams L, Simpson AK, Reimann F. A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes. 52: 1147-54. PMID 12716745 DOI: 10.2337/diabetes.52.5.1147  1
2003 Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM. Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population. Diabetologia. 46: 241-9. PMID 12627323 DOI: 10.1007/s00125-002-1014-3  1
2003 Gribble FM, Reimann F. Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions. Journal of Diabetes and Its Complications. 17: 11-5. PMID 12623163 DOI: 10.1016/S1056-8727(02)00272-6  1
2003 Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM. Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. The Journal of Physiology. 547: 159-68. PMID 12562963 DOI: 10.1113/jphysiol.2002.031625  1
2003 Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M. A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet (London, England). 361: 301-7. PMID 12559865 DOI: 10.1016/S0140-6736(03)12325-2  1
2002 Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea stimulation of insulin secretion. Diabetes. 51: S368-76. PMID 12475777  1
2002 Reimann F, Gribble FM. Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes. 51: 2757-63. PMID 12196469  1
2002 Gribble FM, Reimann F. Pharmacological modulation of K(ATP) channels. Biochemical Society Transactions. 30: 333-9. PMID 12023875 DOI: 10.1042/  1
2001 Reimann F, Ashcroft FM, Gribble FM. Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 50: 2253-9. PMID 11574406  1
2001 Reimann F, Proks P, Ashcroft FM. Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. British Journal of Pharmacology. 132: 1542-8. PMID 11264248 DOI: 10.1038/sj.bjp.0703962  1
2000 Reimann F, Gribble FM, Ashcroft FM. Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. Molecular Pharmacology. 58: 1318-25. PMID 11093769  1
2000 Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko HL, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. The Journal of Clinical Investigation. 106: 897-906. PMID 11018078 DOI: 10.1172/JCI9804  1
2000 Fuchs M, Reimann FM, Gaebel C, Ludwig D, Stange EF. Treatment of infected pancreatic pseudocysts by endoscopic ultrasonography-guided cystogastrostomy Endoscopy. 32: 654-657. PMID 10935798 DOI: 10.1055/s-2000-4660  1
2000 Behrens R, Nolting A, Reimann F, Schwarz M, Waldschütz R, Pongs O. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel β subunit family Febs Letters. 474: 99-106. PMID 10828459 DOI: 10.1016/S0014-5793(00)01584-2  1
2000 Gribble FM, Reimann F, Ashfield R, Ashcroft FM. Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A. Molecular Pharmacology. 57: 1256-61. PMID 10825398  1
2000 Reimann FM, Samson U, Derad I, Fuchs M, Schiefer B, Stange EF. Synergistic sedation with low-dose midazolam and propofol for colonoscopies Endoscopy. 32: 239-244. PMID 10718390 DOI: 10.1055/s-2000-134  1
1999 Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM. The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP. The Journal of Physiology. 520: 661-9. PMID 10545134 DOI: 10.1111/j.1469-7793.1999.00661.x  1
1999 Reimann F, Ashcroft FM. Inwardly rectifying potassium channels Current Opinion in Cell Biology. 11: 503-508. PMID 10449331 DOI: 10.1016/S0955-0674(99)80073-8  1
1999 Reimann F, Tucker SJ, Proks P, Ashcroft FM. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor. The Journal of Physiology. 518: 325-36. PMID 10381582 DOI: 10.1111/j.1469-7793.1999.0325p.x  1
1998 Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, Ashcroft FM. Molecular determinants of KATP channel inhibition by ATP. The Embo Journal. 17: 3290-6. PMID 9628866 DOI: 10.1093/emboj/17.12.3290  1
1997 Reimann FM, Schreiber M, Lerche L, Brüning A, Stange EF. Gastrointestinal diseases in the elderly | Gastroenterologische probleme des alten patienten Zeitschrift Fur Gerontologie Und Geriatrie. 30: 208-219. PMID 9333452  1
1997 Klinger A, Reimann FM, Klinger MHF, Stange EF. Clathrin-mediated endocytosis of high density lipoprotein, in human intestinal Caco-2 cells. A post-embedding immunocytochemical study Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1345: 65-70. PMID 9084502 DOI: 10.1016/S0005-2760(96)00164-6  1
1996 Reimann FM, Winkelmann F, Fellermann K, Stange EF. Reduced cholesterol esterification in CaCo-2 cells by indirect action of pravastatin Atherosclerosis. 125: 63-70. PMID 8831928 DOI: 10.1016/0021-9150(96)05848-0  1
1992 Reimann FM, Herold G, Grosshans I, Rogler G, Fellermann K, Stange EF. Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal caco-2 cells Digestion. 51: 10-17. PMID 1639221 DOI: 10.1159/000200870  1
1992 Rogler G, Herold G, Fahr C, Fahr M, Rogler D, Reimann FM, Stange EF. High-density lipoprotein 3 retroendocytosis: A new lipoprotein pathway in the enterocyte (Caco-2) Gastroenterology. 103: 469-480. PMID 1634065  1
1992 Fellermann K, Reimann FM, Herold G, Stange EF. Mevinolin, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase, suppresses enterocyte esterification of exogenous but not endogenous cholesterol Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1165: 78-83. PMID 1420351 DOI: 10.1016/0005-2760(92)90078-A  1
1992 Reimann F, Fischer S. The latest KNAUER sequencer with the new "loop reactor" for higher reproducibility of reagent delivery Journal of Protein Chemistry. 11: 359-360. DOI: 10.1007/BF01673711  1
1991 Stange EE, Frühholz M, Osenbrügge M, Reimann F, Ditschuneit H. Bezafibrate fails to directly modulate HMG-CoA reductase or LDL catabolism in human mononuclear cells European Journal of Clinical Pharmacology. 40: S37-S40. PMID 2044641 DOI: 10.1007/BF01409406  1
1991 Reimann FM, Herold G, Schneider A, Stange EF. Compartmentalization of cholesterol metabolism and cellular growth in cultured intestinal crypt cells Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1085: 315-321. PMID 1911865 DOI: 10.1016/0005-2760(91)90135-5  1
1991 Stange EF, Osenbrügge M, Rustan M, Reimann F, Schneider A, Ditschuneit HH, Ditschuneit H. Inhibition of HMG-CoA reductase in mononuclear cells during gemfibrozil treatment Atherosclerosis. 91: 257-265. PMID 1789808 DOI: 10.1016/0021-9150(91)90173-Z  1
1991 Stange EF, Rogler G, Reimann F, Herold G. Cholesterol absorption and metabolism in the small intestine | Cholesterinabsorption und -stoffwechsel im Dünndarm Zeitschrift Fur Gastroenterologie. Verhandlungsband. 26: 100-101. PMID 1714113  1
1990 Diniz CR, do Nascimento Cordeiro M, Junor LR, Kelly P, Fischer S, Reimann F, Oliveira EB, Richardson M. The purification and amino acid sequence of the lethal neurotoxin Tx1 from the venom of the Brazilian 'armed' spider Phoneutria nigriventer Febs Letters. 263: 251-253. PMID 2335228 DOI: 10.1016/0014-5793(90)81386-3  1
1990 Herold G, Rogler G, Reimann FM, Stange EF. Regulation of intestinal cholesterol metabolism | Regulation des intestinalen Cholesterinstoffwechsels Klinische Wochenschrift. 68: 1-6. PMID 1964987  1
1988 Stange EF, Preclik G, Schneider A, Reimann F. The role of enterocyte cholesterol metabolism in intestinal cell growth and differentiation Scandinavian Journal of Gastroenterology, Supplement. 151: 79-85. PMID 3067345  1
1988 Reimann FM, Herold G, Stange EF. Compartmentalisation of cholesterol metabolism in cultured intestinal cells Agents and Actions Supplements. 26: 67-81. PMID 3064574  1
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