Fiona M. Gribble - Publications

Clinical Biochemistry University of Cambridge, Cambridge, England, United Kingdom 

269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Guccio N, Gribble FM, Reimann F. Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential. Annual Review of Nutrition. PMID 35609956 DOI: 10.1146/annurev-nutr-062320-113625  0.543
2022 Koo A, Pustovit RV, Woodward ORM, Lewis JE, Gribble FM, Hossain MA, Reimann F, Furness JB. Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine. Cell and Tissue Research. PMID 35596811 DOI: 10.1007/s00441-022-03635-8  0.52
2022 Calderon RM, Smith CA, Miedzybrodzka EL, Silvaroli JA, Golczak M, Gribble FM, Reimann F, Blaner WS. Intestinal enteroendocrine cell signaling: Retinol-binding protein 2 (RBP2) and retinoid actions. Endocrinology. PMID 35552670 DOI: 10.1210/endocr/bqac064  0.549
2022 Smith C, Patterson-Cross R, Woodward O, Lewis J, Chiarugi D, Merkle F, Gribble F, Reimann F, Adriaenssens A. A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide-expressing cells in the hypothalamus. Appetite. 174: 106022. PMID 35430298 DOI: 10.1016/j.appet.2022.106022  0.568
2022 Miedzybrodzka EL, Reimann F, Gribble FM. The Enteroendocrine System in Obesity. Handbook of Experimental Pharmacology. PMID 35419621 DOI: 10.1007/164_2022_582  0.532
2022 Miedzybrodzka EL, Gribble FM, Reimann F. Targeting the Enteroendocrine System for Treatment of Obesity. Handbook of Experimental Pharmacology. PMID 35419620 DOI: 10.1007/164_2022_583  0.548
2022 Veprik A, Denwood G, Liu D, Bany Bakar R, Morfin V, McHugh K, Tebeka NN, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn KL, Hemsley PA, Ahnfelt-Rønne J, Rorsman P, et al. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Communications Biology. 5: 238. PMID 35304577 DOI: 10.1038/s42003-022-03170-w  0.591
2022 Campbell JE, Beaudry JL, Svendsen B, Baggio LL, Gordon AN, Ussher JR, Wong CK, Gribble FM, D'Alessio DA, Reimann F, Drucker DJ. The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue. Diabetes. PMID 35192688 DOI: 10.2337/db21-1166  0.513
2021 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells (Molecular metabolism. 2019 Nov;29:158-169). Molecular Metabolism. 101399. PMID 34863700 DOI: 10.1016/j.molmet.2021.101399  0.56
2021 Miedzybrodzka EL, Foreman RE, Lu VB, George AL, Smith CA, Larraufie P, Kay RG, Goldspink DA, Reimann F, Gribble FM. Stimulation of motilin secretion by bile, free fatty acids and acidification in human duodenal organoids. Molecular Metabolism. 101356. PMID 34662713 DOI: 10.1016/j.molmet.2021.101356  0.516
2021 Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, ... ... Gribble FM, et al. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Scientific Reports. 11: 17571. PMID 34475432 DOI: 10.1038/s41598-021-96278-8  0.441
2021 Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (Gip) Levels and Cardiovascular Disease Risk are Driven by Distinct Causal Variants in the Gipr Region. Diabetes. PMID 34426508 DOI: 10.2337/db21-0103  0.427
2021 Galvin SG, Kay RG, Foreman R, Larraufie P, Meek CL, Biggs E, Ravn P, Jermutus L, Reimann F, Gribble FM. The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1. Journal of Proteome Research. PMID 34423991 DOI: 10.1021/acs.jproteome.1c00463  0.544
2021 Kuhre RE, Modvig IM, Jepsen SL, Kizilkaya HS, Bæch-Laursen C, Smith CA, Reimann F, Gribble FM, Rosenkilde MM, Holst JJ. L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion. Frontiers in Endocrinology. 12: 690387. PMID 34421821 DOI: 10.3389/fendo.2021.690387  0.556
2021 Foreman RE, George AL, Reimann F, Gribble FM, Kay RG. Peptidomics: A Review of Clinical Applications and Methodologies. Journal of Proteome Research. PMID 34270237 DOI: 10.1021/acs.jproteome.1c00295  0.491
2021 Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE. GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders. Diabetes. PMID 34176786 DOI: 10.2337/dbi21-0002  0.486
2021 Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE. GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders. Diabetes. PMID 34176786 DOI: 10.2337/dbi21-0002  0.486
2021 Woodward OR, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding. The Journal of Physiology. PMID 34152020 DOI: 10.1113/JP280581  0.507
2021 Woodward OR, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding. The Journal of Physiology. PMID 34152020 DOI: 10.1113/JP280581  0.507
2021 Napso T, Zhao X, Lligoña MI, Sandovici I, Kay RG, George AL, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN. Placental secretome characterization identifies candidates for pregnancy complications. Communications Biology. 4: 701. PMID 34103657 DOI: 10.1038/s42003-021-02214-x  0.44
2021 Kay RG, Barker P, Burling K, Cohen M, Halsall D, Reimann F, Gribble FM, Semple RK, Church D. Increased C-Peptide Immunoreactivity in Insulin Autoimmune Syndrome (Hirata Disease) Due to High Molecular Weight Proinsulin. Clinical Chemistry. 67: 854-862. PMID 34051096 DOI: 10.1093/clinchem/hvab043  0.501
2021 Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, ... ... Gribble FM, et al. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience. PMID 34002087 DOI: 10.1038/s41593-021-00854-0  0.489
2021 Dolezalova N, Gruszczyk A, Barkan K, Gamble JA, Galvin S, Moreth T, O'Holleran K, Mahbubani KT, Higgins JA, Gribble FM, Reimann F, Surmacki J, Andrews S, Casey JJ, Pampaloni F, et al. Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Scientific Reports. 11: 10418. PMID 34001961 DOI: 10.1038/s41598-021-89853-6  0.495
2021 Lu VB, Gribble FM, Reimann F. Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion. Nutrients. 13. PMID 33803183 DOI: 10.3390/nu13030883  0.569
2021 Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brandt H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O'Flaherty EAA, Roberts GP, Ämmälä C, ... ... Gribble FM, et al. Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice. Peptides. 170532. PMID 33744371 DOI: 10.1016/j.peptides.2021.170532  0.543
2021 Lafferty RA, Tanday N, Moffett RC, Reimann F, Gribble FM, Flatt PR, Irwin N. Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice. Frontiers in Endocrinology. 12: 633625. PMID 33716983 DOI: 10.3389/fendo.2021.633625  0.517
2021 Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, et al. Central and peripheral GLP-1 systems independently suppress eating. Nature Metabolism. PMID 33589843 DOI: 10.1038/s42255-021-00344-4  0.488
2021 Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink DA, Jenkins B, Koulman A, Brighton CA, Ma M, Lam BYH, Coll AP, O'Rahilly S, Reimann F, Gribble FM. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Scientific Reports. 11: 2529. PMID 33510216 DOI: 10.1038/s41598-021-81349-7  0.545
2021 Yang M, Reimann F, Gribble FM. Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities. Current Opinion in Endocrinology, Diabetes, and Obesity. PMID 33449572 DOI: 10.1097/MED.0000000000000614  0.543
2021 Gribble FM, Reimann F. Metabolic Messengers: glucagon-like peptide 1. Nature Metabolism. PMID 33432200 DOI: 10.1038/s42255-020-00327-x  0.556
2021 Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, ... ... Gribble FM, et al. A cross-platform approach identifies genetic regulators of human metabolism and health. Nature Genetics. 53: 54-64. PMID 33414548 DOI: 10.1038/s41588-020-00751-5  0.483
2020 Miedzybrodzka EL, Foreman RE, Galvin SG, Larraufie P, George AL, Goldspink DA, Reimann F, Gribble FM, Kay RG. Organoid Sample Preparation and Extraction for LC-MS Peptidomics. Star Protocols. 1: 100164. PMID 33377058 DOI: 10.1016/j.xpro.2020.100164  0.443
2020 Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, et al. Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Molecular Metabolism. 101118. PMID 33221554 DOI: 10.1016/j.molmet.2020.101118  0.417
2020 Meek CL, Lewis HB, Burling K, Reinmann F, Gribble F. EXPRESS: Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state. Annals of Clinical Biochemistry. 4563220975658. PMID 33175577 DOI: 10.1177/0004563220975658  0.3
2020 Sarnobat D, Moffett CR, Tanday N, Reimann F, Gribble FM, Flatt PR, Tarasov AI. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation. Biochemical Pharmacology. 182: 114216. PMID 32926875 DOI: 10.1016/J.Bcp.2020.114216  0.592
2020 Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, ... ... Gribble FM, et al. SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Molecular Metabolism. 101071. PMID 32896668 DOI: 10.1016/J.Molmet.2020.101071  0.602
2020 Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM. The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 9. PMID 32723474 DOI: 10.7554/Elife.55164  0.519
2020 Goldspink DA, Lu VB, Miedzybrodzka EL, Smith CA, Foreman RE, Billing LJ, Kay RG, Reimann F, Gribble FM. Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture. Cell Reports. 31: 107833. PMID 32610134 DOI: 10.1016/J.Celrep.2020.107833  0.609
2020 Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM. Mass spectrometric characterisation of the circulating peptidome following oral glucose ingestion in control and gastrectomised patients. Rapid Communications in Mass Spectrometry : Rcm. e8849. PMID 32492232 DOI: 10.1002/Rcm.8849  0.555
2020 Calderon G, McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes. Ebiomedicine. 55: 102759. PMID 32344198 DOI: 10.1016/J.Ebiom.2020.102759  0.566
2020 Lewis JE, Miedzybrodzka EL, Foreman RE, Woodward ORM, Kay RG, Goldspink DA, Gribble FM, Reimann F. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. PMID 32342115 DOI: 10.1007/S00125-020-05149-W  0.614
2020 Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, et al. Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. Molecular Metabolism. 35: 100954. PMID 32244182 DOI: 10.1016/J.Molmet.2020.01.018  0.513
2020 Campbell JR, Martchenko A, Sweeney ME, Maalouf MF, Psichas A, Gribble FM, Reimann F, Brubaker PL. Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion. Endocrinology. PMID 32141504 DOI: 10.1210/endocr/bqaa039  0.544
2020 Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, ... ... Gribble FM, et al. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. PMID 32051582 DOI: 10.1038/S41586-020-2031-4  0.47
2020 Lund ML, Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N. L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling. Diabetes. PMID 32041793 DOI: 10.2337/Db19-0764  0.573
2020 Modvig IM, Andersen DB, Grunddal KV, Kuhre RE, Martinussen C, Christiansen CB, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller KN, Madsbad S, Wewer Albrechtsen NJ, et al. Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine. International Journal of Obesity (2005). PMID 32015474 DOI: 10.1038/S41366-020-0541-7  0.568
2020 Biancolin AD, Martchenko A, Mitova E, Gurges P, Michalchyshyn E, Chalmers JA, Doria A, Mychaleckyj JC, Adriaenssens AE, Reimann F, Gribble FM, Gil-Lozano M, Cox BJ, Brubaker PL. The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. Molecular Metabolism. 31: 124-137. PMID 31918914 DOI: 10.1016/J.Molmet.2019.11.004  0.587
2020 Adriaenssens AE, Gribble FM, Reimann F. The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system Peptides. 125: 170194. PMID 31697967 DOI: 10.1016/J.Peptides.2019.170194  0.629
2020 Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM. Author response: The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling Elife. DOI: 10.7554/Elife.55164.Sa2  0.476
2019 Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr]apelin-13 in humans. Scientific Reports. 9: 19934. PMID 31882594 DOI: 10.1038/S41598-019-56157-9  0.496
2019 Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, ... ... Gribble FM, et al. GDF15 mediates the effects of metformin on body weight and energy balance. Nature. PMID 31875646 DOI: 10.1038/S41586-019-1911-Y  0.538
2019 Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, et al. Glucagon-like peptide 1 (GLP-1). Molecular Metabolism. 30: 72-130. PMID 31767182 DOI: 10.1016/J.Molmet.2019.09.010  0.611
2019 Reimann F, Diakogiannaki E, E Moss C, Gribble FM. Cellular mechanisms governing Glucose-dependent insulinotropic polypeptide secretion. Peptides. 170206. PMID 31756367 DOI: 10.1016/J.Peptides.2019.170206  0.619
2019 Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fändriks L. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet. Gut. PMID 31753852 DOI: 10.1136/Gutjnl-2019-319372  0.585
2019 Sarnobat D, Moffett RC, Gault VA, Tanday N, Reimann F, Gribble FM, Flatt PR, Irwin N. Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic Glu;ROSA26-eYFP mice. Peptides. 170205. PMID 31738969 DOI: 10.1016/J.Peptides.2019.170205  0.569
2019 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Molecular Metabolism. 29: 158-169. PMID 31668387 DOI: 10.1016/J.Molmet.2019.09.001  0.612
2019 Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O'Rahilly S, ... ... Gribble FM, et al. Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion. Scientific Reports. 9: 15574. PMID 31666564 DOI: 10.1038/S41598-019-52049-0  0.564
2019 Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L. Synaptic inputs to the mouse dorsal vagal complex and its resident preproglucagon neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31666353 DOI: 10.1523/Jneurosci.2145-19.2019  0.495
2019 Thiebaud N, Gribble F, Reimann F, Trapp S, Fadool DA. A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Scientific Reports. 9: 15542. PMID 31664163 DOI: 10.1038/S41598-019-51880-9  0.513
2019 Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE. Ghrelin does not directly stimulate secretion of glucagon-like peptide-1. The Journal of Clinical Endocrinology and Metabolism. PMID 31608930 DOI: 10.1210/Clinem/Dgz046  0.571
2019 Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. International Journal of Molecular Sciences. 20. PMID 31509948 DOI: 10.3390/Ijms20184448  0.528
2019 Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, et al. Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 31503512 DOI: 10.1152/Ajpendo.00239.2019  0.622
2019 Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metabolism. PMID 31447324 DOI: 10.1016/J.Cmet.2019.07.013  0.612
2019 Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q. Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca release. The Journal of General Physiology. PMID 31358556 DOI: 10.1085/Jgp.201912351  0.578
2019 Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, et al. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Obesity (Silver Spring, Md.). 27: 1292-1304. PMID 31338999 DOI: 10.1002/Oby.22521  0.557
2019 Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. No direct effect of SGLT2 activity on glucagon secretion. Diabetologia. PMID 30903205 DOI: 10.1007/S00125-019-4849-6  0.594
2019 Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nature Communications. 10: 1029. PMID 30833673 DOI: 10.1038/S41467-019-09045-9  0.627
2019 Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Scientific Reports. 9: 2903. PMID 30814564 DOI: 10.1038/S41598-019-39562-Y  0.33
2019 Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nature Reviews. Endocrinology. PMID 30760847 DOI: 10.1038/S41574-019-0168-8  0.616
2019 Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, ... ... Gribble FM, et al. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. PMID 30733330 DOI: 10.2337/Db18-0883  0.587
2019 Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. The Journal of Clinical Endocrinology and Metabolism. PMID 30726969 DOI: 10.1210/Jc.2018-02503  0.547
2019 Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Reports. 26: 1399-1408.e6. PMID 30726726 DOI: 10.1016/J.Celrep.2019.01.047  0.588
2019 Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, et al. PYY plays a key role in the resolution of diabetes following bariatric surgery in humans. Ebiomedicine. PMID 30639417 DOI: 10.1016/J.Ebiom.2018.12.040  0.562
2019 Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, ... ... Gribble FM, et al. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metabolism. PMID 30639358 DOI: 10.1016/J.Cmet.2018.12.016  0.53
2019 Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, et al. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature Communications. 10: 139. PMID 30635569 DOI: 10.1038/S41467-018-08193-8  0.688
2018 Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, et al. Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Therapy. PMID 30514969 DOI: 10.1038/S41434-018-0052-5  0.531
2018 Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O'Rahilly S, et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 564: 263-267. PMID 30487605 DOI: 10.1038/S41586-018-0753-3  0.511
2018 Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, et al. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Molecular Metabolism. PMID 30472415 DOI: 10.1016/J.Molmet.2018.10.012  0.533
2018 Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes. PMID 30279161 DOI: 10.2337/Db18-0729  0.534
2018 Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. PMID 30239642 DOI: 10.1210/En.2018-00672  0.595
2018 Adriaenssens AE, Reimann F, Gribble FM. Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract. Comprehensive Physiology. 8: 1603-1638. PMID 30215862 DOI: 10.1002/Cphy.C170047  0.576
2018 Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Molecular Metabolism. PMID 30201275 DOI: 10.1016/J.Molmet.2018.08.006  0.534
2018 Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F. Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Molecular Metabolism. PMID 30104166 DOI: 10.1016/J.Molmet.2018.07.011  0.624
2018 Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, et al. Assessment and Management of Anti-insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome. The Journal of Clinical Endocrinology and Metabolism. PMID 30085133 DOI: 10.1210/Jc.2018-00972  0.532
2018 Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient. Nature Cell Biology. PMID 30038251 DOI: 10.1038/S41556-018-0143-Y  0.569
2018 Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM. Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours. Rapid Communications in Mass Spectrometry : Rcm. PMID 29857350 DOI: 10.1002/Rcm.8183  0.484
2018 Lu VB, Gribble FM, Reimann F. Free-fatty acid receptors in enteroendocrine cells. Endocrinology. PMID 29688303 DOI: 10.1210/En.2018-00261  0.581
2018 Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Molecular Metabolism. PMID 29656109 DOI: 10.1016/J.Molmet.2018.03.007  0.563
2018 Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM. Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. PMID 29548882 DOI: 10.1016/J.Soard.2018.01.039  0.546
2018 Augustine V, Gokce SK, Lee S, Wang B, Davidson TJ, Reimann F, Gribble F, Deisseroth K, Lois C, Oka Y. Hierarchical neural architecture underlying thirst regulation. Nature. PMID 29489747 DOI: 10.1038/Nature25488  0.511
2018 Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Molecular Metabolism. PMID 29439854 DOI: 10.1016/J.Molmet.2018.01.021  0.526
2018 Gribble FM, Meek CL, Reimann F. Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies. Peptides. 100: 68-74. PMID 29412834 DOI: 10.1016/J.Peptides.2017.11.008  0.554
2018 Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F. Microbial regulation of the L cell transcriptome. Scientific Reports. 8: 1207. PMID 29352262 DOI: 10.1038/S41598-017-18079-2  0.593
2018 Larraufie P, Martin-Gallausiaux C, Lapaque N, Dore J, Gribble FM, Reimann F, Blottiere HM. SCFAs strongly stimulate PYY production in human enteroendocrine cells. Scientific Reports. 8: 74. PMID 29311617 DOI: 10.1038/S41598-017-18259-0  0.611
2018 Bonis AN, Roberts G, Calderon G, Woodrum J, Salisbury J, Reimann F, Camilleri M, LaRusso NF, Gribble F, Acosta A. 1103 - Fluorescence-Activated Cell Sorting of Enteroendocrine Cells in Humans: Technique Validation by Mucosal Endoscopic Biopsies and Novel Progression to Ex-Vivo Studies Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)31118-1  0.52
2017 Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells. Molecular Metabolism. PMID 29167062 DOI: 10.1016/J.Molmet.2017.11.005  0.575
2017 Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM. Development and characterisation of a novel glucagon like peptide-1 receptor antibody. Diabetologia. PMID 29119245 DOI: 10.1007/S00125-017-4491-0  0.599
2017 Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM. Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine. Molecular Metabolism. 6: 1296-1303. PMID 29031728 DOI: 10.1016/J.Molmet.2017.07.014  0.57
2017 Chimerel C, Riccio C, Murison K, Gribble FM, Reimann F. Optogenetic analysis of depolarization dependent glucagon-like peptide-1 release. Endocrinology. PMID 28938466 DOI: 10.1210/En.2017-00434  0.6
2017 Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F. Chylomicrons stimulate incretin secretion in mouse and human cells. Diabetologia. PMID 28866808 DOI: 10.1007/S00125-017-4420-2  0.598
2017 Kay RG, Galvin S, Larraufie P, Reimann F, Gribble FM. LC/MS based detection and semi-quantitative analysis of INSL5 in human and murine tissues. Rapid Communications in Mass Spectrometry : Rcm. PMID 28857318 DOI: 10.1002/Rcm.7978  0.574
2017 Worthington JJ, Reimann F, Gribble FM. Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity. Mucosal Immunology. 11: 3-20. PMID 28853441 DOI: 10.1038/Mi.2017.73  0.555
2017 Holt MK, Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S. Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse. Molecular Metabolism. 6: 909-921. PMID 28752054 DOI: 10.1016/J.Molmet.2017.06.002  0.498
2017 Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. PMID 28636871 DOI: 10.1016/J.Steroids.2017.06.005  0.538
2017 Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. PMID 28596237 DOI: 10.2337/Db16-1403  0.631
2017 Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. Journal of Visualized Experiments : Jove. PMID 28448057 DOI: 10.3791/55687  0.586
2017 Gribble FM, Reimann F. Signalling in the gut endocrine axis. Physiology & Behavior. PMID 28257936 DOI: 10.1016/J.Physbeh.2017.02.039  0.611
2017 Anderberg RH, Richard JE, Eerola K, Ferreras LL, Nordbeck EB, Hansson C, Nissbrandt H, Berqquist F, Gribble FM, Reimann F, Wernstedt-Asterholm I, Lamy C, Skibicka KP. Glucagon-Like Peptide-1 and its Analogues Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight. Diabetes. PMID 28057699 DOI: 10.2337/Db16-0755  0.545
2017 Biggs EK, Gribble FM, Reimann F. Scaling it down: new in vitro tools to get the balance right. The Biochemical Journal. 474: 47-50. PMID 28008090 DOI: 10.1042/Bcj20160874  0.583
2016 Gribble FM, Diakogiannaki E, Reimann F. Gut Hormone Regulation and Secretion via FFA1 and FFA4. Handbook of Experimental Pharmacology. PMID 27873089 DOI: 10.1007/164_2016_46  0.564
2016 Ekberg JH, Hauge M, Kristensen LV, Madsen AN, Engelstoft MS, Husted AS, Sichlau R, Egerod KL, Timshel P, Kowalski TJ, Gribble FM, Reiman F, Hansen HS, Howard AD, Holst B, et al. GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40). Endocrinology. en20161334. PMID 27779915 DOI: 10.1210/En.2016-1334  0.346
2016 Dusaulcy R, Handgraaf S, Skarupelova S, Visentin F, Vesin C, Heddad-Masson M, Reimann F, Gribble F, Philippe J, Gosmain Y. Functional and molecular adaptations of enteroendocrine L-cells in male obese mice are associated with preservation of pancreatic alpha-cells function and prevention of hyperglycemia. Endocrinology. en20161433. PMID 27547850 DOI: 10.1210/En.2016-1433  0.598
2016 Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor dependent GLP-1 and PYY secretion in mice and humans. Endocrinology. en20161384. PMID 27447725 DOI: 10.1210/En.2016-1384  0.567
2016 Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia. PMID 27390011 DOI: 10.1007/S00125-016-4033-1  0.556
2016 Holst JJ, Gribble F, Horowitz M, Rayner CK. Roles of the Gut in Glucose Homeostasis. Diabetes Care. 39: 884-92. PMID 27222546 DOI: 10.2337/Dc16-0351  0.369
2016 Reimann F, Gribble FM. Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion. Journal of Diabetes Investigation. 7: 13-9. PMID 27186350 DOI: 10.1111/Jdi.12478  0.649
2016 Anesten FB, Holt MK, Schéle E, Palsdottir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon (PPG) neurons in the hindbrain have IL-6 Receptor α (IL-6Rα) and show Ca2+ influx in response to IL-6. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00383.2015. PMID 27097661 DOI: 10.1152/Ajpregu.00383.2015  0.501
2016 Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in Arginine Vasopressin - mediated inhibition of colonic anion secretion. The Journal of Physiology. PMID 27037495 DOI: 10.1113/Jp272053  0.611
2016 Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA. Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. Plos One. 11: e0149549. PMID 27010458 DOI: 10.1371/Journal.Pone.0149549  0.605
2016 Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA. The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. The Journal of Physiology. PMID 26931093 DOI: 10.1113/Jp272322  0.581
2016 Pais R, Gribble FM, Reimann F. Stimulation of incretin secreting cells. Therapeutic Advances in Endocrinology and Metabolism. 7: 24-42. PMID 26885360 DOI: 10.1177/2042018815618177  0.627
2016 Kuhre RE, Wewer Albrechtsen NJ, Deacon C, Balk-Møller E, Rehfeld JF, Reimann F, Gribble F, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells. Journal of Molecular Endocrinology. PMID 26819328 DOI: 10.1530/Jme-15-0293  0.623
2016 Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin. Endocrinology. 157: 536-47. PMID 26696123 DOI: 10.1210/En.2015-1725  0.4
2016 Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin Endocrinology. 157: 536-547. DOI: 10.1210/en.2015-1725  0.503
2016 Reimann F, Gribble FM. Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion Journal of Diabetes Investigation. DOI: 10.1111/jdi.12478  0.536
2015 Challis BG, Albrechtsen NJ, Bansiya V, Burling K, Barker P, Hartmann B, Gribble F, O'Rahilly S, Holst JJ, Simpson HL. Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides. Endocrinology, Diabetes & Metabolism Case Reports. 2015: 150105. PMID 26693280 DOI: 10.1530/Edm-15-0105  0.359
2015 Reimann F, Gribble FM. G protein-coupled receptors as new therapeutic targets for type 2 diabetes. Diabetologia. PMID 26661410 DOI: 10.1007/S00125-015-3825-Z  0.558
2015 Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. British Journal of Pharmacology. PMID 26661062 DOI: 10.1111/Bph.13407  0.65
2015 Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides. PMID 26541888 DOI: 10.1016/J.Peptides.2015.10.008  0.584
2015 Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Molecular Metabolism. 4: 718-31. PMID 26500843 DOI: 10.1016/J.Molmet.2015.07.008  0.565
2015 Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Habib A, Egerod KL, Jensen SM, Gribble F, Schwartz TW, Reimann F, Holst JJ. GLP1 and GIP cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. The Journal of Endocrinology. PMID 26483393 DOI: 10.1530/Joe-15-0247  0.63
2015 Gribble FM, Reimann F. Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium. Annual Review of Physiology. PMID 26442437 DOI: 10.1146/Annurev-Physiol-021115-105439  0.59
2015 Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA. Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells. Molecular Metabolism. 4: 619-30. PMID 26413468 DOI: 10.1016/J.Molmet.2015.06.007  0.624
2015 Meek CL, Lewis HB, Reimann F, Gribble FM, Park AJ. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides. PMID 26344355 DOI: 10.1016/J.Peptides.2015.08.013  0.575
2015 Meek CL, Reimann F, Park AJ, Gribble FM. Can encapsulated glutamine increase GLP-1 secretion, improve glucose tolerance, and reduce meal size in healthy volunteers? A randomised, placebo-controlled, cross-over trial. Lancet (London, England). 385: S68. PMID 26312890 DOI: 10.1016/S0140-6736(15)60383-X  0.573
2015 Brighton CA, Rievaj J, Kuhre RE, Glass LL, Schoonjans K, Holst JJ, Gribble FM, Reimann F. Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology. 156: 3961-70. PMID 26280129 DOI: 10.1210/En.2015-1321  0.595
2015 Adriaenssens A, Lam BY, Billing L, Skeffington K, Sewing S, Reimann F, Gribble F. A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology. 156: 3924-36. PMID 26241122 DOI: 10.1210/En.2015-1301  0.564
2015 Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides. PMID 26215048 DOI: 10.1016/J.Peptides.2015.07.019  0.621
2015 Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides. PMID 26145551 DOI: 10.1016/J.Peptides.2015.06.006  0.606
2015 Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides. PMID 26144594 DOI: 10.1016/J.Peptides.2015.06.012  0.728
2015 Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, ... ... Gribble FM, et al. Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nature Communications. 6: 7629. PMID 26134028 DOI: 10.1038/Ncomms8629  0.641
2015 Lewis HB, Ahern AL, Solis-Trapala I, Walker CG, Reimann F, Gribble FM, Jebb SA. Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults. Obesity (Silver Spring, Md.). 23: 1362-70. PMID 26054049 DOI: 10.1002/Oby.21105  0.507
2015 Emery EC, Habib AM, Cox JJ, Nicholas AK, Gribble FM, Woods CG, Reimann F. Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7674-81. PMID 25995458 DOI: 10.1523/Jneurosci.3935-14.2015  0.5
2015 Li J, Yu Q, Ahooghalandari P, Gribble FM, Reimann F, Tengholm A, Gylfe E. Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25911612 DOI: 10.1096/Fj.14-265918  0.567
2015 Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, et al. LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Molecular Metabolism. 4: 277-86. PMID 25830091 DOI: 10.1016/J.Molmet.2015.01.006  0.603
2015 Richard JE, Anderberg RH, Göteson A, Gribble FM, Reimann F, Skibicka KP. Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system. Plos One. 10: e0119034. PMID 25793511 DOI: 10.1371/Journal.Pone.0119034  0.517
2015 Stamenkovic JA, Andersson LE, Adriaenssens AE, Bagge A, Sharoyko VV, Gribble F, Reimann F, Wollheim CB, Mulder H, Spégel P. Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion. The Biochemical Journal. 468: 49-63. PMID 25731850 DOI: 10.1042/Bj20140697  0.63
2015 Psichas A, Reimann F, Gribble FM. Gut chemosensing mechanisms. The Journal of Clinical Investigation. 125: 908-17. PMID 25664852 DOI: 10.1172/Jci76309  0.567
2015 Gribble FM. An absorbing sense of sweetness. Diabetes. 64: 338-40. PMID 25614668 DOI: 10.2337/Db14-1477  0.479
2015 Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ. Targeting development of incretin-producing cells increases insulin secretion. The Journal of Clinical Investigation. 125: 379-85. PMID 25500886 DOI: 10.1172/Jci75838  0.637
2015 Llewellyn-Smith IJ, Marina N, Manton RN, Reimann F, Gribble FM, Trapp S. Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons. Neuroscience. 284: 872-87. PMID 25450967 DOI: 10.1016/J.Neuroscience.2014.10.043  0.488
2015 Emery EC, Diakogiannaki E, Gentry C, Psichas A, Habib AM, Bevan S, Fischer MJ, Reimann F, Gribble FM. Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1. Diabetes. 64: 1202-10. PMID 25325736 DOI: 10.2337/db14-0737  0.587
2015 Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain Molecular Metabolism. DOI: 10.1016/j.molmet.2015.07.008  0.502
2015 Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA. Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells Molecular Metabolism. 4: 619-630. DOI: 10.1016/j.molmet.2015.06.007  0.541
2014 Chimerel C, Emery E, Summers DK, Keyser U, Gribble FM, Reimann F. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Reports. 9: 1202-8. PMID 25456122 DOI: 10.1016/J.Celrep.2014.10.032  0.603
2014 Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metabolism. 20: 1018-29. PMID 25453189 DOI: 10.1016/J.Cmet.2014.10.004  0.616
2014 Samocha-Bonet D, Chisholm DJ, Gribble FM, Coster AC, Carpenter KH, Jones GR, Holst JJ, Greenfield JR. Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. Plos One. 9: e113366. PMID 25412338 DOI: 10.1371/Journal.Pone.0113366  0.319
2014 Parker HE, Gribble FM, Reimann F. The role of gut endocrine cells in control of metabolism and appetite. Experimental Physiology. 99: 1116-20. PMID 25210110 DOI: 10.1113/Expphysiol.2014.079764  0.638
2014 Zac-Varghese S, Trapp S, Richards P, Sayers S, Sun G, Bloom SR, Reimann F, Gribble FM, Rutter GA. The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Disease Models & Mechanisms. 7: 1275-86. PMID 25190708 DOI: 10.1242/Dmm.014720  0.585
2014 Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of Physiology. 592: 4677-96. PMID 25172946 DOI: 10.1113/Jphysiol.2014.274209  0.648
2014 Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature Communications. 5: 4639. PMID 25145789 DOI: 10.1038/Ncomms5639  0.7
2014 Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature. 514: 503-7. PMID 25141178 DOI: 10.1038/Nature13633  0.58
2014 Richard JE, Farkas I, Anesten F, Anderberg RH, Dickson SL, Gribble FM, Reimann F, Jansson JO, Liposits Z, Skibicka KP. GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence. Endocrinology. 155: 4356-67. PMID 25116706 DOI: 10.1210/En.2014-1248  0.548
2014 Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4972-85. PMID 25070369 DOI: 10.1096/Fj.14-257667  0.554
2014 Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, ... ... Gribble FM, et al. Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proceedings of the National Academy of Sciences of the United States of America. 111: 11133-8. PMID 25028498 DOI: 10.1073/Pnas.1411413111  0.635
2014 Kuhre RE, Gribble FM, Hartmann B, Reimann F, Windeløv JA, Rehfeld JF, Holst JJ. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G622-30. PMID 24525020 DOI: 10.1152/Ajpgi.00372.2013  0.64
2014 Richards P, Parker HE, Adriaenssens AE, Hodgson JM, Cork SC, Trapp S, Gribble FM, Reimann F. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes. 63: 1224-33. PMID 24296712 DOI: 10.2337/Db13-1440  0.609
2014 Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ. Generation of L cells in mouse and human small intestine organoids. Diabetes. 63: 410-20. PMID 24130334 DOI: 10.2337/Db13-0991  0.597
2013 Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, ... ... Gribble F, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metabolism. 18: 871-82. PMID 24315372 DOI: 10.1016/J.Cmet.2013.10.014  0.706
2013 Reimann F, Gribble FM. Towards the harnessing of gut feelings. Current Opinion in Pharmacology. 13: 909-11. PMID 24140240 DOI: 10.1016/J.Coph.2013.09.020  0.477
2013 Reimann F, Gribble FM. A tag to track short chain fatty acid sensors. Endocrinology. 154: 3492-4. PMID 24058154 DOI: 10.1210/En.2013-1789  0.616
2013 Diakogiannaki E, Pais R, Tolhurst G, Parker HE, Horscroft J, Rauscher B, Zietek T, Daniel H, Gribble FM, Reimann F. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 56: 2688-96. PMID 24045836 DOI: 10.1007/S00125-013-3037-3  0.623
2013 Ezcurra M, Reimann F, Gribble FM, Emery E. Molecular mechanisms of incretin hormone secretion. Current Opinion in Pharmacology. 13: 922-7. PMID 24035446 DOI: 10.1016/J.Coph.2013.08.013  0.638
2013 Habib AM, Richards P, Rogers GJ, Reimann F, Gribble FM. Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia. 56: 1413-6. PMID 23519462 DOI: 10.1007/S00125-013-2887-Z  0.608
2013 Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T. The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. The Journal of Biological Chemistry. 288: 4513-21. PMID 23269670 DOI: 10.1074/Jbc.M112.402677  0.581
2013 Llewellyn-Smith IJ, Gnanamanickam GJ, Reimann F, Gribble FM, Trapp S. Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience. 229: 130-43. PMID 23069752 DOI: 10.1016/J.Neuroscience.2012.09.071  0.491
2012 Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, et al. PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. The Journal of Clinical Investigation. 122: 4105-17. PMID 23093780 DOI: 10.1172/Jci42127  0.597
2012 Gribble FM. The gut endocrine system as a coordinator of postprandial nutrient homoeostasis. The Proceedings of the Nutrition Society. 71: 456-62. PMID 22906726 DOI: 10.1017/S0029665112000705  0.325
2012 Moss CE, Marsh WJ, Parker HE, Ogunnowo-Bada E, Riches CH, Habib AM, Evans ML, Gribble FM, Reimann F. Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents. Diabetologia. 55: 3094-103. PMID 22872212 DOI: 10.1007/S00125-012-2663-5  0.74
2012 Garfield AS, Patterson C, Skora S, Gribble FM, Reimann F, Evans ML, Myers MG, Heisler LK. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology. 153: 4600-7. PMID 22869346 DOI: 10.1210/En.2012-1282  0.546
2012 Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F, Gribble FM. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology. 153: 3054-65. PMID 22685263 DOI: 10.1210/En.2011-2170  0.597
2012 Parker HE, Adriaenssens A, Rogers G, Richards P, Koepsell H, Reimann F, Gribble FM. Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia. 55: 2445-55. PMID 22638549 DOI: 10.1007/S00125-012-2585-2  0.604
2012 Reimann F, Tolhurst G, Gribble FM. G-protein-coupled receptors in intestinal chemosensation. Cell Metabolism. 15: 421-31. PMID 22482725 DOI: 10.1016/J.Cmet.2011.12.019  0.554
2012 Tolhurst G, Reimann F, Gribble FM. Intestinal sensing of nutrients. Handbook of Experimental Pharmacology. 309-35. PMID 22249821 DOI: 10.1007/978-3-642-24716-3_14  0.589
2012 Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J, Reimann F, Gribble FM. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 61: 364-71. PMID 22190648 DOI: 10.2337/Db11-1019  0.638
2012 Diakogiannaki E, Gribble FM, Reimann F. Nutrient detection by incretin hormone secreting cells. Physiology & Behavior. 106: 387-93. PMID 22182802 DOI: 10.1016/J.Physbeh.2011.12.001  0.625
2012 Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, ... ... Gribble FM, et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 61: 187-96. PMID 22124465 DOI: 10.2337/Db11-1029  0.567
2012 Parker HE, Wallis K, le Roux CW, Wong KY, Reimann F, Gribble FM. Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. British Journal of Pharmacology. 165: 414-23. PMID 21718300 DOI: 10.1111/J.1476-5381.2011.01561.X  0.641
2011 Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, ... ... Gribble FM, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature Medicine. 17: 1481-9. PMID 22037645 DOI: 10.1038/Nm.2513  0.579
2011 Hisadome K, Reimann F, Gribble FM, Trapp S. CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 60: 2701-9. PMID 21885869 DOI: 10.2337/Db11-0489  0.527
2011 Samocha-Bonet D, Wong O, Synnott EL, Piyaratna N, Douglas A, Gribble FM, Holst JJ, Chisholm DJ, Greenfield JR. Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients. The Journal of Nutrition. 141: 1233-8. PMID 21593352 DOI: 10.3945/Jn.111.139824  0.419
2011 Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S. Preproglucagon neurons project widely to autonomic control areas in the mouse brain. Neuroscience. 180: 111-21. PMID 21329743 DOI: 10.1016/J.Neuroscience.2011.02.023  0.513
2011 Rogers GJ, Tolhurst G, Ramzan A, Habib AM, Parker HE, Gribble FM, Reimann F. Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells. The Journal of Physiology. 589: 1081-93. PMID 21224236 DOI: 10.1113/Jphysiol.2010.198069  0.606
2011 Tolhurst G, Zheng Y, Parker HE, Habib AM, Reimann F, Gribble FM. Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP. Endocrinology. 152: 405-13. PMID 21209017 DOI: 10.1210/En.2010-0956  0.59
2011 da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, Bugliani M, Marselli L, Marchetti P, Birzele F, Sun G, Scharfmann R, Rutter J, Siniakowicz K, Weir G, ... ... Gribble FM, et al. Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 54: 819-27. PMID 21181396 DOI: 10.1007/S00125-010-2010-7  0.612
2011 Friedlander RS, Moss CE, Mace J, Parker HE, Tolhurst G, Habib AM, Wachten S, Cooper DM, Gribble FM, Reimann F. Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells. British Journal of Pharmacology. 163: 261-71. PMID 21054345 DOI: 10.1111/J.1476-5381.2010.01107.X  0.732
2010 Hisadome K, Reimann F, Gribble FM, Trapp S. Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons. Diabetes. 59: 1890-8. PMID 20522593 DOI: 10.2337/Db10-0128  0.574
2010 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, ... ... Gribble F, et al. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metabolism. 11: 543-53. PMID 20519125 DOI: 10.1016/J.Cmet.2010.04.007  0.6
2010 Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, et al. Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 53: 924-36. PMID 20221584 DOI: 10.1007/S00125-010-1692-1  0.6
2010 Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin DV, McHale DP, Drenth JP, Dai F, Wheeler J, Sanders F, Wood L, Wu TX, Karppinen J, Nikolajsen L, Männikkö M, ... ... Gribble FM, et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proceedings of the National Academy of Sciences of the United States of America. 107: 5148-53. PMID 20212137 DOI: 10.1073/Pnas.0913181107  0.459
2010 Gribble FM. Alpha2A-adrenergic receptors and type 2 diabetes. The New England Journal of Medicine. 362: 361-2. PMID 20107223 DOI: 10.1056/Nejmcibr0911499  0.319
2010 Parker HE, Reimann F, Gribble FM. Molecular mechanisms underlying nutrient-stimulated incretin secretion. Expert Reviews in Molecular Medicine. 12: e1. PMID 20047700 DOI: 10.1017/S146239940900132X  0.634
2009 Guran T, Tolhurst G, Bereket A, Rocha N, Porter K, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, et al. Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. The Journal of Clinical Endocrinology and Metabolism. 94: 3633-9. PMID 19755480 DOI: 10.1210/Jc.2009-0551  0.523
2009 Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, ... ... Gribble FM, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 58: 2070-83. PMID 19542200 DOI: 10.2337/Db09-0551  0.579
2009 Ong WK, Gribble FM, Reimann F, Lynch MJ, Houslay MD, Baillie GS, Furman BL, Pyne NJ. The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. British Journal of Pharmacology. 157: 633-44. PMID 19371330 DOI: 10.1111/J.1476-5381.2009.00194.X  0.602
2009 Gribble FM. Intolerant of glucose and gasping for oxygen. Nature Medicine. 15: 247-9. PMID 19265823 DOI: 10.1038/Nm0309-247  0.388
2009 Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia. 52: 289-98. PMID 19082577 DOI: 10.1007/S00125-008-1202-X  0.632
2009 Greenfield JR, Farooqi IS, Keogh JM, Henning E, Habib AM, Blackwood A, Reimann F, Holst JJ, Gribble FM. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. The American Journal of Clinical Nutrition. 89: 106-13. PMID 19056578 DOI: 10.3945/Ajcn.2008.26362  0.59
2009 Tolhurst G, Reimann F, Gribble FM. Nutritional regulation of glucagon-like peptide-1 secretion. The Journal of Physiology. 587: 27-32. PMID 19001044 DOI: 10.1113/Jphysiol.2008.164012  0.618
2009 Trapp S, Hisadome K, Reimann F, Gribble F. S8.2 Regulation of excitability of GLP-1 releasing NTS neurons — Do these cells signal satiety? Autonomic Neuroscience. 149: 35. DOI: 10.1016/J.Autneu.2009.05.042  0.532
2008 Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM. Glucose sensing in L cells: a primary cell study. Cell Metabolism. 8: 532-9. PMID 19041768 DOI: 10.1016/J.Cmet.2008.11.002  0.644
2008 Gribble FM. RD Lawrence Lecture 2008: Targeting GLP-1 release as a potential strategy for the therapy of Type 2 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association. 25: 889-94. PMID 18959599 DOI: 10.1111/J.1464-5491.2008.02514.X  0.446
2008 Casas S, Novials A, Reimann F, Gomis R, Gribble FM. Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia. 51: 2252-62. PMID 18751967 DOI: 10.1007/S00125-008-1111-Z  0.57
2008 Evans JM, Ogston SA, Reimann F, Gribble FM, Morris AD, Pearson ER. No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis. Diabetes, Obesity & Metabolism. 10: 350-2. PMID 18093208 DOI: 10.1111/J.1463-1326.2007.00833.X  0.477
2008 Wallis K, Parker HE, Le Roux CW, Ghatei MA, Forbes A, Gabe SM, Gribble F, Walters JR. T1834 Bile Acids Stimulate Glucagon Like Peptide- 2 Secretion from L-Cells; Possible Mediation Through Membrane Receptor TGR5 Gastroenterology. 134: A-573. DOI: 10.1016/S0016-5085(08)62675-X  0.38
2007 Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, Reimann F, Gribble FM. Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line. Diabetologia. 50: 2181-9. PMID 17643200 DOI: 10.1007/S00125-007-0750-9  0.615
2007 Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A. Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis. Diabetes. 56: 2284-94. PMID 17563070 DOI: 10.2337/Db07-0178  0.325
2007 Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ. TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes. 56: 1943-7. PMID 17416797 DOI: 10.2337/Db07-0055  0.353
2006 Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, ... ... Gribble FM, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 444: 894-8. PMID 17167479 DOI: 10.1038/Nature05413  0.542
2006 O'Malley D, Reimann F, Simpson AK, Gribble FM. Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes. 55: 3381-6. PMID 17130483 DOI: 10.2337/Db06-0531  0.568
2006 Pryor PR, Reimann F, Gribble FM, Luzio JP. Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (Copenhagen, Denmark). 7: 1388-98. PMID 16978393 DOI: 10.1111/J.1600-0854.2006.00475.X  0.492
2006 Reimann F, Ward PS, Gribble FM. Signaling mechanisms underlying the release of glucagon-like peptide 1 Diabetes. 55: S78-S85. DOI: 10.2337/Db06-S010  0.645
2005 Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, Simpson AK, Gribble FM. The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line. The Journal of Physiology. 569: 761-72. PMID 16223757 DOI: 10.1113/Jphysiol.2005.098962  0.577
2005 Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT. Relapsing diabetes can result from moderately activating mutations in KCNJ11. Human Molecular Genetics. 14: 925-34. PMID 15718250 DOI: 10.1093/Hmg/Ddi086  0.619
2005 Reimann F, Maziarz M, Flock G, Habib AM, Drucker DJ, Gribble FM. Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line. The Journal of Physiology. 563: 161-75. PMID 15611035 DOI: 10.1113/Jphysiol.2004.076414  0.619
2004 Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, ... ... Gribble FM, et al. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 47: A1-A464. PMID 27770180 DOI: 10.1007/Bf03375463  0.477
2004 Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM. Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia. 47: 1592-601. PMID 15365617 DOI: 10.1007/S00125-004-1498-0  0.63
2004 Gribble FM, Reimann F. Open to control--new hope for patients with neonatal diabetes. The New England Journal of Medicine. 350: 1817-8. PMID 15115828 DOI: 10.1056/Nejmp048044  0.621
2003 Gribble FM, Reimann F. Sulphonylurea action revisited: the post-cloning era. Diabetologia. 46: 875-91. PMID 12819907 DOI: 10.1007/S00125-003-1143-3  0.582
2003 Gribble FM, Williams L, Simpson AK, Reimann F. A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes. 52: 1147-54. PMID 12716745 DOI: 10.2337/Diabetes.52.5.1147  0.625
2003 Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM. Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population. Diabetologia. 46: 241-9. PMID 12627323 DOI: 10.1007/S00125-002-1014-3  0.661
2003 Gribble FM, Reimann F. Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions. Journal of Diabetes and Its Complications. 17: 11-5. PMID 12623163 DOI: 10.1016/S1056-8727(02)00272-6  0.568
2003 Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM. Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. The Journal of Physiology. 547: 159-68. PMID 12562963 DOI: 10.1113/jphysiol.2002.031625  0.651
2003 Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM. Analysis of the differential modulation of sulphonylurea block of β‐cell and cardiac ATP‐sensitive K+ (KATP) channels by Mg‐nucleotides The Journal of Physiology. 547: 159-168. DOI: 10.1111/J.1469-7793.2003.00159.X  0.677
2003 Gribble FM, Reimann F. KATP channel pharmacology in the pancreas and the cardiovascular system International Congress Series. 1253: 279-287. DOI: 10.1016/S0531-5131(03)00132-8  0.463
2002 Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea stimulation of insulin secretion. Diabetes. 51: S368-76. PMID 12475777 DOI: 10.2337/Diabetes.51.2007.S368  0.671
2002 Reimann F, Gribble FM. Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes. 51: 2757-63. PMID 12196469 DOI: 10.2337/Diabetes.51.9.2757  0.645
2002 Gribble FM, Reimann F. Pharmacological modulation of K(ATP) channels. Biochemical Society Transactions. 30: 333-9. PMID 12023875 DOI: 10.1042/  0.513
2001 Reimann F, Ashcroft FM, Gribble FM. Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 50: 2253-9. PMID 11574406 DOI: 10.2337/Diabetes.50.10.2253  0.659
2001 Gribble FM, Manley SE, Levy JC. Randomized dose ranging study of the reduction of fasting and postprandial glucose in type 2 diabetes by nateglinide (A-4166). Diabetes Care. 24: 1221-5. PMID 11423506 DOI: 10.2337/Diacare.24.7.1221  0.331
2001 Gribble FM, Ashcroft FM. Differentsirovannaya chuvstvitel'nost' ?-kletochnykh i ekstrapankreaticheskikh ATF zavisimykh K kanalov k gliklazidu Diabetes Mellitus. 4: 13-15. DOI: 10.14341/2072-0351-6101  0.39
2000 Ashcroft FM, Gribble FM. New windows on the mechanism of action of K(ATP) channel openers. Trends in Pharmacological Sciences. 21: 439-45. PMID 11121575 DOI: 10.1016/S0165-6147(00)01563-7  0.534
2000 Reimann F, Gribble FM, Ashcroft FM. Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. Molecular Pharmacology. 58: 1318-25. PMID 11093769 DOI: 10.1124/Mol.58.6.1318  0.649
2000 Gribble FM, Ashcroft FM. Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism: Clinical and Experimental. 49: 3-6. PMID 11078468  0.521
2000 Gribble FM, Davis TM, Higham CE, Clark A, Ashcroft FM. The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. British Journal of Pharmacology. 131: 756-60. PMID 11030725 DOI: 10.1038/Sj.Bjp.0703638  0.566
2000 Ashcroft FM, Gribble FM. Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels. Journal of Diabetes and Its Complications. 14: 192-6. PMID 11004427 DOI: 10.1016/S1056-8727(00)00081-7  0.565
2000 Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM. A novel method for measurement of submembrane ATP concentration. The Journal of Biological Chemistry. 275: 30046-9. PMID 10866996 DOI: 10.1074/Jbc.M001010200  0.652
2000 Gribble FM, Reimann F, Ashfield R, Ashcroft FM. Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A. Molecular Pharmacology. 57: 1256-61. PMID 10825398  0.621
2000 Gribble FM, Ashcroft FM. Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels fromcells and extrapancreatic tissues Metabolism-Clinical and Experimental. 49: 3-6. DOI: 10.1053/Meta.2000.17822  0.572
1999 Le Brigand L, Virsolvy A, Manechez D, Godfroid JJ, Guardiola-Lemaître B, Gribble FM, Ashcroft FM, Bataille D. In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound. British Journal of Pharmacology. 128: 1021-6. PMID 10556939 DOI: 10.1038/Sj.Bjp.0702883  0.595
1999 Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia. 42: 903-19. PMID 10491749 DOI: 10.1007/S001250051247  0.554
1999 Gribble FM, Ashcroft FM. Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide. Diabetologia. 42: 845-8. PMID 10440127 DOI: 10.1007/S001250051236  0.552
1999 Ashfield R, Gribble FM, Ashcroft SJ, Ashcroft FM. Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel. Diabetes. 48: 1341-7. PMID 10342826 DOI: 10.2337/Diabetes.48.6.1341  0.547
1999 Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM. Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP. The Journal of Physiology. 514: 19-25. PMID 9831713 DOI: 10.1111/J.1469-7793.1999.019Af.X  0.653
1998 Gribble FM, Proks P, Corkey BE, Ashcroft FM. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. The Journal of Biological Chemistry. 273: 26383-7. PMID 9756869 DOI: 10.1074/Jbc.273.41.26383  0.585
1998 Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. Diabetes. 47: 1412-8. PMID 9726229 DOI: 10.2337/Diabetes.47.9.1412  0.682
1998 Ashcroft FM, Gribble FM. Correlating structure and function in ATP-sensitive K+ channels. Trends in Neurosciences. 21: 288-94. PMID 9683320 DOI: 10.1016/S0166-2236(98)01225-9  0.567
1998 Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Proceedings of the National Academy of Sciences of the United States of America. 95: 8387-91. PMID 9653196 DOI: 10.1073/Pnas.95.14.8387  0.616
1998 Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, Ashcroft FM. Molecular determinants of KATP channel inhibition by ATP. The Embo Journal. 17: 3290-6. PMID 9628866 DOI: 10.1093/Emboj/17.12.3290  0.721
1998 Gribble FM, Tucker SJ, Haug T, Ashcroft FM. MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit. Proceedings of the National Academy of Sciences of the United States of America. 95: 7185-90. PMID 9618560 DOI: 10.1073/Pnas.95.12.7185  0.691
1997 Gribble FM, Tucker SJ, Ashcroft FM. The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation. The Journal of Physiology. 504: 35-45. PMID 9350615 DOI: 10.1111/J.1469-7793.1997.00035.X  0.662
1997 Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature. 387: 179-83. PMID 9144288 DOI: 10.1038/387179A0  0.688
1997 Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. The Embo Journal. 16: 1145-52. PMID 9135131 DOI: 10.1093/Emboj/16.6.1145  0.695
1997 Gribble FM, Ashfield R, Ammälä C, Ashcroft FM. Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes. The Journal of Physiology. 498: 87-98. PMID 9023770 DOI: 10.1113/Jphysiol.1997.Sp021843  0.555
1996 Rachman J, Gribble FM, Barrow BA, Levy JC, Buchanan KD, Turner RC. Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM. Diabetes. 45: 1524-30. PMID 8866556 DOI: 10.2337/Diab.45.11.1524  0.402
1996 Tucker SJ, Pessia M, Moorhouse AJ, Gribble F, Ashcroft FM, Maylie J, Adelman JP. Heteromeric channel formation and Ca2+-free media reduce the toxic effect of the weaver K(ir), 3.2 allele Febs Letters. 390: 253-257. PMID 8706871 DOI: 10.1016/0014-5793(96)00635-7  0.675
1996 Ammälä C, Moorhouse A, Gribble F, Ashfield R, Proks P, Smith PA, Sakura H, Coles B, Ashcroft SJ, Ashcroft FM. Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature. 379: 545-8. PMID 8596634 DOI: 10.1038/379545A0  0.577
1995 Sakura H, Ammälä C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. Febs Letters. 377: 338-44. PMID 8549751 DOI: 10.1016/0014-5793(95)01369-5  0.556
1995 Bond CT, Ämmälä C, Ashfield R, Blair TA, Gribble F, Khan RN, Lee K, Proks P, Rowe ICM, Sakura H, Ashford MJ, Adelman JP, Ashcroft FM. Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic β-cells and in the brain Febs Letters. 367: 61-66. PMID 7601286 DOI: 10.1016/0014-5793(95)00497-W  0.558
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