Ernest Fraenkel, Ph.D.
Affiliations: | Biological Engineering | Massachusetts Institute of Technology, Cambridge, MA, United States |
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"Ernest Fraenkel"Children
Sign in to add trainee| Amanda J Kedaigle | grad student | MIT (Chemistry Tree) | |
| Shao-Shan Carol Huang | grad student | 2011 | MIT |
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Publications
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| Akimov SS, Jiang M, Kedaigle AJ, et al. (2021) Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics. Human Molecular Genetics |
| Smith-Geater C, Hernandez SJ, Lim RG, et al. (2020) Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation. Stem Cell Reports |
| Patel-Murray NL, Adam M, Huynh N, et al. (2020) A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules. Scientific Reports. 10: 954 |
| Chapman OS, Ehrenberger T, Archer TC, et al. (2020) Abstract 447: Integrated omics modeling of transcriptional regulation in medulloblastoma subtypes Cancer Research. 80: 447-447 |
| Yildirim F, Ng CW, Kappes V, et al. (2019) Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America |
| Kedaigle AJ, Reidling JC, Lim RG, et al. (2019) Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice. Human Molecular Genetics |
| Woo AJ, Patry CA, Ghamari A, et al. (2019) Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Advances. 3: 2499-2511 |
| Kedaigle AJ, Fraenkel E, Atwal RS, et al. (2019) Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites. Human Molecular Genetics |
| Köksal AS, Beck K, Cronin DR, et al. (2018) Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data. Cell Reports. 24: 3607-3618 |
| Archer TC, Ehrenberger T, Mundt F, et al. (2018) Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 34: 396-410.e8 |