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Ohara Augusto, Ph.D. - Publications

Affiliations: 
1977- Departamento de Bioquímica University of São Paulo, São Paulo, São Paulo, Brazil 
Area:
Chemistry and Biochemistry of Free Radicals, Applications of Electronic Paramagnetic Resonance (EPR) in Biomedicine, Biological Oxidations, Redox Equilibrium in cells and organisms, Nitric Oxide and derived oxidants
Website:
http://www.iq.usp.br/oaugusto/indexing.html
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137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dantas LS, Viviani LG, Inague A, Piccirillo E, Rezende L, Ronsein GE, Augusto O, Medeiros MHG, Amaral ATD, Miyamoto S. Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation. Free Radical Biology & Medicine. 156: 157-167. PMID 32598986 DOI: 10.1016/J.Freeradbiomed.2020.05.011  0.355
2020 Truzzi DR, Alves SV, Netto LES, Augusto O. The Peroxidatic Thiol of Peroxiredoxin 1 is Nitrosated by Nitrosoglutathione but Coordinates to the Dinitrosyl Iron Complex of Glutathione. Antioxidants (Basel, Switzerland). 9. PMID 32218363 DOI: 10.3390/Antiox9040276  0.309
2020 Gonçalves LCP, Massari J, Licciardi S, Prado FM, Linares E, Klassen A, Tavares MFM, Augusto O, Di Mascio P, Bechara EJH. Singlet oxygen generation by the reaction of acrolein with peroxynitrite via a 2-hydroxyvinyl radical intermediate. Free Radical Biology & Medicine. 152: 83-90. PMID 32145303 DOI: 10.1016/J.Freeradbiomed.2020.03.003  0.436
2019 Truzzi DR, Augusto O, Iretskii AV, Ford PC. Dynamics of Dinitrosyl Iron Complex (DNIC) Formation with Low Molecular Weight Thiols. Inorganic Chemistry. PMID 31535856 DOI: 10.1021/Acs.Inorgchem.9B02338  0.351
2019 Truzzi DR, Coelho FR, Paviani V, Alves SV, Netto LES, Augusto O. The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1. The Journal of Biological Chemistry. PMID 31366734 DOI: 10.1074/Jbc.Ra119.008825  0.421
2019 Truzzi DR, Augusto O, Ford PC. Thiyl radicals are co-products of dinitrosyl iron complex (DNIC) formation. Chemical Communications (Cambridge, England). PMID 31304495 DOI: 10.1039/C9Cc04454J  0.361
2019 Augusto O, Goldstein S, Hurst JK, Lind J, Lymar SV, Merenyi G, Radi R. Carbon Dioxide-catalyzed peroxynitrite reactivity - The Resilience of the radical mechanism after two decades of research. Free Radical Biology & Medicine. PMID 30818056 DOI: 10.1016/J.Freeradbiomed.2019.02.026  0.371
2018 Damasceno FC, Condeles AL, Lopes AKB, Facci RR, Linares E, Truzzi DR, Augusto O, Toledo JC. The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source. The Journal of Biological Chemistry. PMID 29661935 DOI: 10.1074/Jbc.Ra117.000883  0.448
2018 Truzzi DR, Coelho FR, Paviani V, Alves SV, Netto LE, Augusto O. Bicarbonate increases peroxiredoxin 1 susceptibility to hyperoxidation Free Radical Biology and Medicine. 120: S37. DOI: 10.1016/J.Freeradbiomed.2018.04.125  0.382
2018 Augusto O. CO 2 toxicity: Role for redox reactions? Free Radical Biology and Medicine. 120: S23. DOI: 10.1016/J.Freeradbiomed.2018.04.094  0.338
2017 Peixoto AS, Geyer RR, Iqbal A, Truzzi DR, Soares Moretti AI, Laurindo FRM, Augusto O. Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein disulfide isomerase. The Journal of Biological Chemistry. PMID 29191937 DOI: 10.1074/Jbc.M117.807016  0.453
2017 Carvalho LA, Truzzi DR, Fallani TS, Alves SV, Toledo Junior JC, Augusto O, Netto LE, Meotti FC. Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2. The Journal of Biological Chemistry. PMID 28348082 DOI: 10.1074/Jbc.M116.767657  0.445
2017 Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovanni M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín DA, Heijnen HF, Piacenza L, Radi R. Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). Proceedings of the National Academy of Sciences of the United States of America. PMID 28179568 DOI: 10.1073/Pnas.1618611114  0.394
2017 Paviani V, Galdino GT, Prazeres JNd, Queiroz RF, Augusto O. Ditryptophan Cross-Links as Novel Products of Protein Oxidation Journal of the Brazilian Chemical Society. 29: 925-933. DOI: 10.21577/0103-5053.20170239  0.366
2017 Guercio AMFD, Alegria TGP, Meireles DdA, Truzzi DR, Neto JFdS, Augusto O, Trujillo M, Netto LES. Kinetic Characterization of the Redox Regulation of OhrR Free Radical Biology and Medicine. 112: 22-23. DOI: 10.1016/J.Freeradbiomed.2017.10.020  0.374
2016 Weller CE, Dhall A, Ding F, Linares E, Whedon SD, Senger NA, Tyson EL, Bagert JD, Li X, Augusto O, Chatterjee C. Aromatic thiol-mediated cleavage of N-O bonds enables chemical ubiquitylation of folded proteins. Nature Communications. 7: 12979. PMID 27680493 DOI: 10.1038/Ncomms12979  0.308
2016 Tairum CA, Santos MC, Breyer CA, Geyer RR, Nieves CJ, Portillo-Ledesma S, Ferrer-Sueta G, Toledo JC, Toyama MH, Augusto O, Netto LE, de Oliveira MA. Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. Scientific Reports. 6: 33133. PMID 27629822 DOI: 10.1038/Srep33133  0.304
2016 Gatti RM, Augusto O, Kwee JK, Giorgio S. Leishmanicidal activity of peroxynitrite. Redox Report : Communications in Free Radical Research. 1: 261-5. PMID 27405713 DOI: 10.1080/13510002.1995.11746996  0.376
2016 Truzzi DR, Alves SS, Netto LE, Augusto O. Peroxiredoxin 1 Coordination to the Dinitrosyl Iron Complex of Glutathione Free Radical Biology and Medicine. 100: S113. DOI: 10.1016/J.Freeradbiomed.2016.10.291  0.333
2016 Tairum CA, Cardoso Santos M, Alexandre Breyer C, Ryan Geyer R, Nieves CJ, Portillo-Ledesma S, Ferrer-Sueta G, Carlos Toledo-Jr J, Hikari Toyama M, Augusto O, Netto LES, Antonio de Oliveira M. Tsa1 and Tsa2 Are Two Highly Similar 2-Cys Prx from Yeast That Display Remarkable Differences in Their Structural Switches Free Radical Biology and Medicine. 100: S110-S111. DOI: 10.1016/J.Freeradbiomed.2016.10.284  0.36
2016 Souza Dantas L, Rodrigues Coelho F, Rezende L, Marques Peron L, Tavares do Amaral A, Medeiros MHG, Augusto O, Miyamoto S. Lipid-Derived Electrophiles Induce Covalent Modification and Aggregation of Cu,Zn-Superoxide Dismutase in a Hydrophobicity-Dependent Manner Free Radical Biology and Medicine. 100: S65. DOI: 10.1016/J.Freeradbiomed.2016.10.169  0.36
2016 Paviani V, Augusto O. The Overlooked Ditryptophan Cross-Link Is Present in Bovine Beta Crystalline Submitted to UVC or Solar Simulator Irradiation Free Radical Biology and Medicine. 100: S19. DOI: 10.1016/J.Freeradbiomed.2016.10.042  0.343
2015 Paviani V, Queiroz RF, Marques EF, Di Mascio P, Augusto O. Production of lysozyme and lysozyme-superoxide dismutase dimers bound by a ditryptophan cross-link in carbonate radical-treated lysozyme. Free Radical Biology & Medicine. 89: 72-82. PMID 26197052 DOI: 10.1016/J.Freeradbiomed.2015.07.015  0.456
2015 Appolinário PP, Medinas DB, Chaves-Filho AB, Genaro-Mattos TC, Cussiol JR, Netto LE, Augusto O, Miyamoto S. Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols. Plos One. 10: e0125146. PMID 25928076 DOI: 10.1371/Journal.Pone.0125146  0.354
2015 Genaro-Mattos TC, Queiroz RF, Cunha D, Appolinario PP, Di Mascio P, Nantes IL, Augusto O, Miyamoto S. Cytochrome c reacts with cholesterol hydroperoxides to produce lipid- and protein-derived radicals. Biochemistry. 54: 2841-50. PMID 25865416 DOI: 10.1021/Bi501409D  0.366
2015 Lima FL, Joazeiro PP, Lancellotti M, de Hollanda LM, de Araújo Lima B, Linares E, Augusto O, Brocchi M, Giorgio S. Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages. Future Microbiology. 10: 179-89. PMID 25689530 DOI: 10.2217/Fmb.14.111  0.313
2015 Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radical Biology & Medicine. 78: 233-5. PMID 25462642 DOI: 10.1016/J.Freeradbiomed.2014.10.504  0.396
2014 Coelho FR, Iqbal A, Linares E, Silva DF, Lima FS, Cuccovia IM, Augusto O. Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme. The Journal of Biological Chemistry. 289: 30690-701. PMID 25237191 DOI: 10.1074/Jbc.M114.586370  0.442
2014 Iqbal A, Paviani V, Moretti AI, Laurindo FR, Augusto O. Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase. Archives of Biochemistry and Biophysics. 557: 72-81. PMID 24956592 DOI: 10.1016/J.Abb.2014.06.013  0.469
2014 Dal Vechio FH, Cerqueira F, Augusto O, Lopes R, Demasi M. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radical Biology & Medicine. 67: 304-13. PMID 24291399 DOI: 10.1016/J.Freeradbiomed.2013.11.017  0.376
2014 Paviani V, Queiroz RF, Marquez EF, Di Mascio P, Augusto O. MS Characterization of the Ditryptophan Cross-Links in Lysozyme Submitted to Enzymatically and Photolytically Generated Carbonate Radicals Free Radical Biology and Medicine. 76: S159. DOI: 10.1016/J.Freeradbiomed.2014.10.068  0.31
2014 Iqbal A, Augusto O, Paviane V, Iochabel Moretti A, Laurindo FR. Corrigendum to "Inactivation and aggregation of protein disulfide isomerase by enzymatically and photolytically generated carbonate radical" [Free Rad. Biol. Med. 65 (suppl. 2) (2013) S54] Free Radical Biology and Medicine. 68: 259. DOI: 10.1016/J.Freeradbiomed.2013.12.008  0.36
2013 Queiroz RF, Paviani V, Coelho FR, Marques EF, Di Mascio P, Augusto O. The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol. The Biochemical Journal. 455: 37-46. PMID 23855710 DOI: 10.1042/Bj20130180  0.44
2013 Queliconi BB, Marazzi TB, Vaz SM, Brookes PS, Nehrke K, Augusto O, Kowaltowski AJ. Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion. Free Radical Biology & Medicine. 55: 46-53. PMID 23195687 DOI: 10.1016/J.Freeradbiomed.2012.11.007  0.345
2013 Iqbal A, Augusto O. Inactivation and Aggregation of Protein Disulfide Isomerase by Enzymatically and Photolytically Generated Carbonate Radical Free Radical Biology and Medicine. 65: S54. DOI: 10.1016/J.Freeradbiomed.2013.10.518  0.352
2012 Queiroz RF, Jordão AK, Cunha AC, Ferreira VF, Brigagão MR, Malvezzi A, Amaral AT, Augusto O. Nitroxides attenuate carrageenan-induced inflammation in rat paws by reducing neutrophil infiltration and the resulting myeloperoxidase-mediated damage. Free Radical Biology & Medicine. 53: 1942-53. PMID 22982597 DOI: 10.1016/J.Freeradbiomed.2012.09.001  0.314
2012 Toledo JC, Augusto O. Connecting the chemical and biological properties of nitric oxide. Chemical Research in Toxicology. 25: 975-89. PMID 22449080 DOI: 10.1021/Tx300042G  0.423
2011 Queiroz RF, Vaz SM, Augusto O. Inhibition of the chlorinating activity of myeloperoxidase by tempol: revisiting the kinetics and mechanisms. The Biochemical Journal. 439: 423-31. PMID 21749327 DOI: 10.1042/Bj20110555  0.414
2011 Toledo JC, Audi R, Ogusucu R, Monteiro G, Netto LE, Augusto O. Horseradish peroxidase compound I as a tool to investigate reactive protein-cysteine residues: from quantification to kinetics. Free Radical Biology & Medicine. 50: 1032-8. PMID 21354305 DOI: 10.1016/J.Freeradbiomed.2011.02.020  0.377
2010 Medinas DB, Gozzo FC, Santos LF, Iglesias AH, Augusto O. A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity. Free Radical Biology & Medicine. 49: 1046-53. PMID 20600836 DOI: 10.1016/J.Freeradbiomed.2010.06.018  0.392
2010 Medinas DB, Augusto O. Mechanism of the peroxidase activity of superoxide dismutase 1. Free Radical Biology & Medicine. 49: 682; author reply 68. PMID 20553855 DOI: 10.1016/J.Freeradbiomed.2010.04.040  0.325
2009 Vieira AL, Linares E, Augusto O, Gomes SL. Evidence of a Ca(2+)-(*)NO-cGMP signaling pathway controlling zoospore biogenesis in the aquatic fungus Blastocladiella emersonii. Fungal Genetics and Biology : Fg & B. 46: 575-84. PMID 19393757 DOI: 10.1016/J.Fgb.2009.04.002  0.413
2009 Medinas DB, Toledo JC, Cerchiaro G, do-Amaral AT, de-Rezende L, Malvezzi A, Augusto O. Peroxymonocarbonate and carbonate radical displace the hydroxyl-like oxidant in the Sod1 peroxidase activity under physiological conditions. Chemical Research in Toxicology. 22: 639-48. PMID 19243126 DOI: 10.1021/Tx800287M  0.453
2009 Vaz SM, Prado FM, Di Mascio P, Augusto O. Oxidation and nitration of ribonuclease and lysozyme by peroxynitrite and myeloperoxidase. Archives of Biochemistry and Biophysics. 484: 127-33. PMID 19135975 DOI: 10.1016/J.Abb.2008.12.017  0.432
2009 Ogusucu R, Rettori D, Netto LE, Augusto O. Superoxide dismutase 1-mediated production of ethanol- and DNA-derived radicals in yeasts challenged with hydrogen peroxide: molecular insights into the genome instability of peroxiredoxin-null strains. The Journal of Biological Chemistry. 284: 5546-56. PMID 19106092 DOI: 10.1074/Jbc.M805526200  0.429
2008 Vaz SM, Augusto O. Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications. Proceedings of the National Academy of Sciences of the United States of America. 105: 8191-6. PMID 18499804 DOI: 10.1073/Pnas.0708211105  0.463
2008 Augusto O, Trindade DF, Linares E, Vaz SM. Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications. Anais Da Academia Brasileira De CiêNcias. 80: 179-89. PMID 18345386 DOI: 10.1590/S0001-37652008000100013  0.459
2008 Linares E, Giorgio S, Augusto O. Inhibition of in vivo leishmanicidal mechanisms by tempol: nitric oxide down-regulation and oxidant scavenging. Free Radical Biology & Medicine. 44: 1668-76. PMID 18313408 DOI: 10.1016/J.Freeradbiomed.2008.01.027  0.427
2007 Medinas DB, Cerchiaro G, Trindade DF, Augusto O. The carbonate radical and related oxidants derived from bicarbonate buffer. Iubmb Life. 59: 255-62. PMID 17505962 DOI: 10.1080/15216540701230511  0.394
2007 Monteiro G, Horta BB, Pimenta DC, Augusto O, Netto LE. Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proceedings of the National Academy of Sciences of the United States of America. 104: 4886-91. PMID 17360337 DOI: 10.1073/Pnas.0700481104  0.389
2007 Ogusucu R, Rettori D, Munhoz DC, Netto LE, Augusto O. Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics. Free Radical Biology & Medicine. 42: 326-34. PMID 17210445 DOI: 10.1016/J.Freeradbiomed.2006.10.042  0.346
2007 Augusto O, Muntz Vaz S. EPR spin-trapping of protein radicals to investigate biological oxidative mechanisms. Amino Acids. 32: 535-42. PMID 17048125 DOI: 10.1007/S00726-006-0429-4  0.457
2007 Cerqueira FM, De Medeiros MHG, Augusto O. Dietetic antioxidants: Controversies and perspectives | Antioxidantes dietéticos: Controvérsias e perspectivas Quimica Nova. 30: 441-449. DOI: 10.1590/S0100-40422007000200036  0.379
2006 Trindade DF, Cerchiaro G, Augusto O. A role for peroxymonocarbonate in the stimulation of biothiol peroxidation by the bicarbonate/carbon dioxide pair. Chemical Research in Toxicology. 19: 1475-82. PMID 17112235 DOI: 10.1021/Tx060146X  0.401
2006 Tsuhako MH, Augusto O, Linares E, Dagli ML, Pereira CA. Association between nitric oxide synthesis and vaccination-acquired resistance to murine hepatitis virus by spf mice. Free Radical Biology & Medicine. 41: 1534-41. PMID 17045921 DOI: 10.1016/J.Freeradbiomed.2006.08.011  0.336
2006 Miyamoto S, Martinez GR, Rettori D, Augusto O, Medeiros MH, Di Mascio P. Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen. Proceedings of the National Academy of Sciences of the United States of America. 103: 293-8. PMID 16387855 DOI: 10.1073/Pnas.0508170103  0.346
2006 Keppler AF, Cerchiaro G, Augusto O, Miyamoto S, Prado F, Di Mascio P, Comasseto JV. Organic tellurium-centered radicals evidenced by EPR spin trapping and mass spectrometry experiments: Insights into the mechanism of the hydrotelluration reaction Organometallics. 25: 5059-5066. DOI: 10.1021/Om060560S  0.391
2006 Modolo LV, Augusto O, Almeida IMG, Pinto-Maglio CAF, Oliveira HC, Seligman K, Salgado I. Decreased arginine and nitrite levels in nitrate reductase-deficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae Plant Science. 171: 34-40. DOI: 10.1016/J.Plantsci.2006.02.010  0.32
2005 Lima ES, Bonini MG, Augusto O, Barbeiro HV, Souza HP, Abdalla DS. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radical Biology & Medicine. 39: 532-9. PMID 16043024 DOI: 10.1016/J.Freeradbiomed.2005.04.005  0.449
2005 Modolo LV, Augusto O, Almeida IM, Magalhaes JR, Salgado I. Nitrite as the major source of nitric oxide production by Arabidopsis thaliana in response to Pseudomonas syringae. Febs Letters. 579: 3814-20. PMID 15978583 DOI: 10.1016/J.Febslet.2005.05.078  0.376
2005 Fernandes DC, Medinas DB, Alves MJ, Augusto O. Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation. Free Radical Biology & Medicine. 38: 189-200. PMID 15607902 DOI: 10.1016/J.Freeradbiomed.2004.09.027  0.463
2004 Bonini MG, Miyamoto S, Di Mascio P, Augusto O. Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate. The Journal of Biological Chemistry. 279: 51836-43. PMID 15448145 DOI: 10.1074/Jbc.M406929200  0.493
2004 Augusto O, Bonini MG, Trindade D. Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants. Free Radical Biology & Medicine. 36: 1224-32. PMID 15110387 DOI: 10.1016/J.Freeradbiomed.2004.02.076  0.445
2004 Chen YR, Chen CL, Chen W, Zweier JL, Augusto O, Radi R, Mason RP. Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. The Journal of Biological Chemistry. 279: 18054-62. PMID 14761966 DOI: 10.1074/Jbc.M307706200  0.397
2004 Bonini MG, Fernandes DC, Augusto O. Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals. Biochemistry. 43: 344-51. PMID 14717588 DOI: 10.1021/Bi035606P  0.439
2003 Romero N, Radi R, Linares E, Augusto O, Detweiler CD, Mason RP, Denicola A. Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. The Journal of Biological Chemistry. 278: 44049-57. PMID 12920120 DOI: 10.1074/Jbc.M305895200  0.484
2003 Nakao LS, Iwai LK, Kalil J, Augusto O. Radical production from free and peptide-bound methionine sulfoxide oxidation by peroxynitrite and hydrogen peroxide/iron(II). Febs Letters. 547: 87-91. PMID 12860391 DOI: 10.1016/S0014-5793(03)00674-4  0.458
2003 Aliaga C, Lissi EA, Augusto O, Linares E. Kinetics and mechanism of the reaction of a nitroxide radical (tempol) with a phenolic antioxidant. Free Radical Research. 37: 225-30. PMID 12688417 DOI: 10.1080/1071576031000081587  0.34
2003 Linares E, Nakao LS, Augusto O, Kadiiska MB. EPR studies of in vivo radical production by lipopolysaccharide: potential role of iron mobilized from iron-nitrosyl complexes. Free Radical Biology & Medicine. 34: 766-73. PMID 12633753 DOI: 10.1016/S0891-5849(02)01424-7  0.439
2002 Augusto O, Lopes de Menezes S, Linares E, Romero N, Radi R, Denicola A. EPR detection of glutathiyl and hemoglobin-cysteinyl radicals during the interaction of peroxynitrite with human erythrocytes. Biochemistry. 41: 14323-8. PMID 12450398 DOI: 10.1021/Bi0262202  0.483
2002 Augusto O, Bonini MG, Amanso AM, Linares E, Santos CC, De Menezes SL. Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. Free Radical Biology & Medicine. 32: 841-59. PMID 11978486 DOI: 10.1016/S0891-5849(02)00786-4  0.458
2002 Bonini MG, Mason RP, Augusto O. The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species. Chemical Research in Toxicology. 15: 506-11. PMID 11952336 DOI: 10.1021/Tx015571Z  0.446
2001 Lopes de Menezes S, Augusto O. EPR detection of glutathionyl and protein-tyrosyl radicals during the interaction of peroxynitrite with macrophages (J774). The Journal of Biological Chemistry. 276: 39879-84. PMID 11518708 DOI: 10.1074/Jbc.M104012200  0.458
2001 Linares E, Giorgio S, Mortara RA, Santos CX, Yamada AT, Augusto O. Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation. Free Radical Biology & Medicine. 30: 1234-42. PMID 11368921 DOI: 10.1016/S0891-5849(01)00516-0  0.414
2001 Bonini MG, Augusto O. Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite. The Journal of Biological Chemistry. 276: 9749-54. PMID 11134018 DOI: 10.1074/Jbc.M008456200  0.48
2000 Batthyány C, Santos CX, Botti H, Cerveñansky C, Radi R, Augusto O, Rubbo H. Direct evidence for apo B-100-mediated copper reduction: studies with purified apo B-100 and detection of tryptophanyl radicals. Archives of Biochemistry and Biophysics. 384: 335-40. PMID 11368321 DOI: 10.1006/Abbi.2000.2102  0.325
2000 Hix S, Kadiiska MB, Mason RP, Augusto O. In vivo metabolism of tert-butyl hydroperoxide to methyl radicals. EPR spin-trapping and DNA methylation studies. Chemical Research in Toxicology. 13: 1056-64. PMID 11080055 DOI: 10.1021/Tx000130L  0.368
2000 Janiszewski M, Pedro MA, Scheffer RC, van Asseldonk JH, Souza LC, da Luz PL, Augusto O, Laurindo FR. Inhibition of vascular NADH/NADPH oxidase activity by thiol reagents: lack of correlation with cellular glutathione redox status. Free Radical Biology & Medicine. 29: 889-99. PMID 11063914 DOI: 10.1016/S0891-5849(00)00393-2  0.41
2000 Nakao LS, Kadiiska MB, Mason RP, Grijalba MT, Augusto O. Metabolism of acetaldehyde to methyl and acetyl radicals: in vitro and in vivo electron paramagnetic resonance spin-trapping studies. Free Radical Biology & Medicine. 29: 721-9. PMID 11053773 DOI: 10.1016/S0891-5849(00)00374-9  0.448
2000 Martinez GR, Di Mascio P, Bonini MG, Augusto O, Briviba K, Sies H, Maurer P, Röthlisberger U, Herold S, Koppenol WH. Peroxynitrite does not decompose to singlet oxygen ((1)Delta (g)O(2)) andnitroxyl (NO(-)). Proceedings of the National Academy of Sciences of the United States of America. 97: 10307-12. PMID 10973492 DOI: 10.1073/Pnas.190256897  0.337
2000 Souza HP, Souza LC, Anastacio VM, Pereira AC, Junqueira ML, Krieger JE, da Luz PL, Augusto O, Laurindo FR. Vascular oxidant stress early after balloon injury: evidence for increased NAD(P)H oxidoreductase activity. Free Radical Biology & Medicine. 28: 1232-42. PMID 10889453 DOI: 10.1016/S0891-5849(00)00240-9  0.41
2000 Santos CX, Bonini MG, Augusto O. Role of the carbonate radical anion in tyrosine nitration and hydroxylation by peroxynitrite. Archives of Biochemistry and Biophysics. 377: 146-52. PMID 10775454 DOI: 10.1006/Abbi.2000.1751  0.446
1999 Santos CX, Anjos EI, Augusto O. Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Archives of Biochemistry and Biophysics. 372: 285-94. PMID 10600166 DOI: 10.1006/Abbi.1999.1491  0.493
1999 Nakao LS, Ouchi D, Augusto O. Oxidation of acetaldehyde by peroxynitrite and hydrogen Peroxide/Iron(II). Production Of acetate, formate, and methyl radicals. Chemical Research in Toxicology. 12: 1010-8. PMID 10525279 DOI: 10.1021/Tx990055I  0.489
1999 Hix S, Augusto O. DNA methylation by tert-butyl hydroperoxide-iron (II): a role for the transition metal ion in the production of DNA base adducts. Chemico-Biological Interactions. 118: 141-9. PMID 10359458 DOI: 10.1016/S0009-2797(99)00079-4  0.324
1999 Bonini MG, Radi R, Ferrer-Sueta G, Ferreira AM, Augusto O. Direct EPR detection of the carbonate radical anion produced from peroxynitrite and carbon dioxide. The Journal of Biological Chemistry. 274: 10802-6. PMID 10196155 DOI: 10.1074/Jbc.274.16.10802  0.356
1999 Linares E, Giorgio S, Mortara RA, Augusto O. Late nitric oxide synthesis during cutaneous murine leishmaniasis Free Radical Biology and Medicine. 27: S80. DOI: 10.1016/S0891-5849(99)90771-2  0.376
1999 Augusto O. Free radical formation from peroxynitrite: EPR studies in test tubes and cells Free Radical Biology and Medicine. 27: S3. DOI: 10.1016/S0891-5849(99)90517-8  0.348
1998 Kwee JK, Armelin MS, Stefani HA, Augusto O. Cell proliferation induced by 8-oxoguanosine and 8-methylguanosine, two adducts produced by free radical attack on ribonucleosides and RNA. Chemico-Biological Interactions. 116: 61-77. PMID 9877201 DOI: 10.1016/S0009-2797(98)00079-9  0.332
1998 Nakao LS, Augusto O. Nucleic acid alkylation by free radical metabolites of ethanol. Formation of 8-(1-hydroxyethyl)guanine and 8-(2-hydroxyethyl)guanine adducts. Chemical Research in Toxicology. 11: 888-94. PMID 9705750 DOI: 10.1021/Tx9800351  0.355
1998 Pedro MA, Augusto O, Barbeiro HV, Carvalho MH, da-Luz PL, Laurindo FR. Nonspecific blockade of vascular free radical signals by methylated arginine analogues. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 31: 749-55. PMID 9698818 DOI: 10.1590/S0100-879X1998000600004  0.344
1998 Giorgio S, Linares E, Ischiropoulos H, Von Zuben FJ, Yamada A, Augusto O. In vivo formation of electron paramagnetic resonance-detectable nitric oxide and of nitrotyrosine is not impaired during murine leishmaniasis. Infection and Immunity. 66: 807-14. PMID 9453645 DOI: 10.1128/Iai.66.2.807-814.1998  0.345
1998 Gatti RM, Alvarez B, Vasquez-Vivar J, Radi R, Augusto O. Formation of spin trap adducts during the decomposition of peroxynitrite. Archives of Biochemistry and Biophysics. 349: 36-46. PMID 9439580 DOI: 10.1006/Abbi.1997.0451  0.471
1997 Vásquez-Vivar J, Denicola A, Radi R, Augusto O. Peroxynitrite-mediated decarboxylation of pyruvate to both carbon dioxide and carbon dioxide radical anion. Chemical Research in Toxicology. 10: 786-94. PMID 9250413 DOI: 10.1021/Tx970031G  0.497
1997 Quijano C, Alvarez B, Gatti RM, Augusto O, Radi R. Pathways of peroxynitrite oxidation of thiol groups. The Biochemical Journal. 322: 167-73. PMID 9078258 DOI: 10.1042/Bj3220167  0.41
1997 de Almeida Ribeiro MC, Augusto O, da Costa Ferreira AM. Influence of quinoline-containing antimalarials in the catalase activity of ferriprotoporphyrin IX Journal of Inorganic Biochemistry. 65: 15-23. DOI: 10.1016/S0162-0134(96)00064-5  0.324
1996 Augusto O, Linares E, Giorgio S. Possible roles of nitric oxide and peroxynitrite in murine leishmaniasis. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 29: 853-62. PMID 9070374  0.325
1996 Giorgio S, Linares E, Capurro Mde L, de Bianchi AG, Augusto O. Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis. Photochemistry and Photobiology. 63: 750-4. PMID 8992499 DOI: 10.1111/J.1751-1097.1996.Tb09626.X  0.409
1996 Augusto O, Radi R, Gatti RM, Vásquez-Vivar J. Detection of secondary radicals from peroxynitrite-medicated oxidations by electron spin resonance. Methods in Enzymology. 269: 346-54. PMID 8791663 DOI: 10.1016/S0076-6879(96)69035-1  0.454
1996 Vásquez-Vivar J, Santos AM, Junqueira VB, Augusto O. Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acid-derived free radicals. The Biochemical Journal. 314: 869-76. PMID 8615782 DOI: 10.1042/Bj3140869  0.476
1995 Denicola A, Souza JM, Gatti RM, Augusto O, Radi R. Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: role of the hydroxamic groups. Free Radical Biology & Medicine. 19: 11-9. PMID 7635352 DOI: 10.1016/0891-5849(94)00239-G  0.47
1995 Hix S, Morais Mda S, Augusto O. DNA methylation by tert-butyl hydroperoxide-iron (II). Free Radical Biology & Medicine. 19: 293-301. PMID 7557543 DOI: 10.1016/0891-5849(95)00026-T  0.327
1995 Ribeiro MCdA, Augusto O, Ferreira AMdC. Inhibitory effect of chloroquine on the peroxidase activity of ferriprotoporphyrin IX Journal of the Chemical Society-Dalton Transactions. 3759-3766. DOI: 10.1039/Dt9950003759  0.348
1994 Vásquez-Vivar J, Augusto O. Oxidative activity of primaquine metabolites on rat erythrocytes in vitro and in vivo. Biochemical Pharmacology. 47: 309-16. PMID 8304975 DOI: 10.1016/0006-2952(94)90022-1  0.469
1994 Augusto O, Gatti RM, Radi R. Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates. Archives of Biochemistry and Biophysics. 310: 118-25. PMID 8161194 DOI: 10.1006/Abbi.1994.1147  0.489
1994 Gatti RM, Radi R, Augusto O. Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical. Febs Letters. 348: 287-90. PMID 8034056 DOI: 10.1016/0014-5793(94)00625-3  0.475
1994 Laurindo FR, Pedro Mde A, Barbeiro HV, Pileggi F, Carvalho MH, Augusto O, da Luz PL. Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism. Circulation Research. 74: 700-9. PMID 7511072 DOI: 10.1161/01.Res.74.4.700  0.368
1993 Augusto O. Alkylation and cleavage of DNA by carbon-centered radical metabolites. Free Radical Biology & Medicine. 15: 329-36. PMID 8406132 DOI: 10.1016/0891-5849(93)90079-A  0.322
1991 Gomes LF, Augusto O. Formation of methyl radicals during the catalase-mediated oxidation of formaldehyde hydrazone. Carcinogenesis. 12: 1351-3. PMID 1649016 DOI: 10.1093/Carcin/12.7.1351  0.451
1991 Netto LE, Ferreira AM, Augusto O. Iron(III) binding in DNA solutions: complex formation and catalytic activity in the oxidation of hydrazine derivatives. Chemico-Biological Interactions. 79: 1-14. PMID 1647885 DOI: 10.1016/0009-2797(91)90048-C  0.333
1991 Augusto O. Carbon-Centered Radicals: Dna Alkylation And Biological Sources Oxidative Damage & Repairchemical, Biological and Medical Aspects. 148-153. DOI: 10.1016/B978-0-08-041749-3.50031-0  0.307
1990 Vasquez-Vivar J, Augusto O. ESR detection of free radical intermediates during autoxidation of 5-hydroxyprimaquine. Free Radical Research Communications. 9: 383-9. PMID 2167276 DOI: 10.3109/10715769009145698  0.358
1990 Augusto O, Vasquez-Vivar J, Morais MS. Red cell oxidative stress caused by the antimalarial primaqui NE: ESR studies Free Radical Biology and Medicine. 9: 37. DOI: 10.1016/0891-5849(90)90301-X  0.336
1989 Monteiro HP, Abdalla DS, Augusto O, Bechara EJ. Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies. Archives of Biochemistry and Biophysics. 271: 206-16. PMID 2540713 DOI: 10.1016/0003-9861(89)90271-3  0.686
1989 Leite LC, Augusto O. DNA alterations induced by the carbon-centered radical derived from the oxidation of 2-phenylethylhydrazine. Archives of Biochemistry and Biophysics. 270: 560-72. PMID 2539776 DOI: 10.1016/0003-9861(89)90538-9  0.461
1989 Tsuhako MH, Alves MJ, Colli W, Brener Z, Augusto O. Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections. Biochemical Pharmacology. 38: 4491-6. PMID 2513811 DOI: 10.1016/0006-2952(89)90661-8  0.395
1988 Netto LE, Leite LC, Augusto O. Hemoglobin-mediated oxidation of the carcinogen 1,2-dimethylhydrazine to methyl radicals. Archives of Biochemistry and Biophysics. 266: 562-72. PMID 2847657 DOI: 10.1016/0003-9861(88)90289-5  0.466
1988 Augusto O, Schreiber J, Mason RP. Direct ESR detection of a free radical intermediate during the peroxidase-catalyzed oxidation of the antimalarial drug primaquine Biochemical Pharmacology. 37: 2791-2797. PMID 2840077 DOI: 10.1016/0006-2952(88)90042-1  0.479
1986 Augusto O, Alves MJ, Colli W, Filardi LS, Brener Z. Primaquine can mediate hydroxyl radical generation by Trypanosoma cruzi extracts. Biochemical and Biophysical Research Communications. 135: 1029-34. PMID 3008737 DOI: 10.1016/0006-291X(86)91031-4  0.399
1986 Augusto O, Weingrill CL, Schreier S, Amemiya H. Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides. Catalysis by hemoglobin and microsomes. Archives of Biochemistry and Biophysics. 244: 147-55. PMID 3004336 DOI: 10.1016/0003-9861(86)90103-7  0.438
1985 Augusto O, Du Plessis LR, Weingrill CL. Spin-trapping of methyl radical in the oxidative metabolism of 1,2-dimethylhydrazine. Biochemical and Biophysical Research Communications. 126: 853-8. PMID 2983693 DOI: 10.1016/0006-291X(85)90263-3  0.458
1984 Augusto O, Faljoni-Alário A, Leite LC, Nóbrega FG. DNA strand scission by the carbon radical derived from 2-phenyl-ethylhydrazine metabolism. Carcinogenesis. 5: 781-4. PMID 6327112 DOI: 10.1093/Carcin/5.6.781  0.413
1983 Ortiz de Montellano PR, Augusto O, Viola F, Kunze KL. Carbon radicals in the metabolism of alkyl hydrazines. The Journal of Biological Chemistry. 258: 8623-9. PMID 6305994  0.546
1982 Augusto O, Kunze KL, Ortiz de Montellano PR. N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate. The Journal of Biological Chemistry. 257: 6231-41. PMID 7076671  0.578
1982 Augusto O, Beilan HS, Ortiz de Montellano PR. The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation. The Journal of Biological Chemistry. 257: 11288-95. PMID 6288676  0.577
1982 Ortiz de Montellano PR, Kunze KL, Augusto O. Hemoprotein destruction. Iron-nitrogen shift of a phenyl group in a porphyrin complex Journal of the American Chemical Society. 104: 3545-3546. DOI: 10.1021/Ja00376A069  0.59
1981 Augusto O, Packer L. Selective inactivation of microsomal drug metabolizing proteins by visible light. Photochemistry and Photobiology. 33: 765-7. PMID 7267726 DOI: 10.1111/J.1751-1097.1981.Tb05488.X  0.488
1981 Augusto O, Ortiz de Montellano PR, Quintanilha A. Spin-trapping of free radicals formed during microsomal metabolism of ethylhydrazine and acetylhydrazine. Biochemical and Biophysical Research Communications. 101: 1324-30. PMID 6272782 DOI: 10.1016/0006-291X(81)91592-8  0.623
1981 Rivas-Suárez E, Augusto O, Cilento G. QUENCHING OF ENZYME GENERATED TRIPLET ACETONE BY 2-METHYL-1,4-NAPHTOQUINONE Photochemistry and Photobiology. 33: 279-282. DOI: 10.1111/J.1751-1097.1981.Tb05340.X  0.568
1980 Augusto O, Bechara EJ. Hemin-catalyzed generation of triplet acetone. Biochimica Et Biophysica Acta. 631: 203-9. PMID 7397246 DOI: 10.1016/0304-4165(80)90068-9  0.643
1980 Haun M, Durán N, Augusto O, Cilento G. Model studies of the α-peroxidase system: Formation of an electronically excited product Archives of Biochemistry and Biophysics. 200: 245-252. PMID 7362254 DOI: 10.1016/0003-9861(80)90351-3  0.584
1979 Augusto O, Cilento G. DARK EXCITATION OF CHLOROPHYLL Photochemistry and Photobiology. 30: 191-193. DOI: 10.1111/J.1751-1097.1979.Tb07135.X  0.562
1978 Augusto O, Cilento G, Jung J, Song PS. Phototransformation of phytochrome in the dark. Biochemical and Biophysical Research Communications. 83: 963-9. PMID 708444 DOI: 10.1016/0006-291X(78)91489-4  0.549
1978 Cilento G, Durán N, Zinner K, Vidigal CCC, Oliveira OMMF, Haun M, Fauoni A, Augusto O, Baptista RCd, Bechara EJH. CHEMIENERGIZED SPECIES IN PEROXIDASE SYSTEMS Photochemistry and Photobiology. 28: 445-450. DOI: 10.1111/J.1751-1097.1978.Tb06945.X  0.591
1977 Augusto O, Cilento G. Conversion of tryptophan to indolacetamide. Evidence for an electronically excited intermediate. Biochemical and Biophysical Research Communications. 79: 1238-44. PMID 603656 DOI: 10.1016/0006-291X(77)91139-1  0.573
1975 Augusto O, Cilento G. The effect of diphenols upon the autoxiation of oxyhemoglobin and oxymyoglobin. Archives of Biochemistry and Biophysics. 168: 549-56. PMID 1169917 DOI: 10.1016/0003-9861(75)90286-6  0.624
1973 Augusto O, Bechara EJ, Sanioto DL, Cilento G. The effect of o-diphenols upon the microsomal NADPH and NADH oxidase activities. Archives of Biochemistry and Biophysics. 158: 359-64. PMID 4147081 DOI: 10.1016/0003-9861(73)90632-2  0.732
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