| Year |
Citation |
Score |
| 2024 |
Vandermeulen L, Geric I, Fumagalli L, Kreir M, Lu A, Nonneman A, Premereur J, Wolfs L, Policarpo R, Fattorelli N, De Bondt A, Van Den Wyngaert I, Asselbergh B, Fiers M, De Strooper B, et al. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. Molecular Neurodegeneration. 19: 37. PMID 38654375 DOI: 10.1186/s13024-024-00725-9 |
0.301 |
|
| 2024 |
Mancuso R, Fattorelli N, Martinez-Muriana A, Davis E, Wolfs L, Van Den Daele J, Geric I, Premereur J, Polanco P, Bijnens B, Preman P, Serneels L, Poovathingal S, Balusu S, Verfaillie C, ... ... De Strooper B, et al. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature Neuroscience. PMID 38539015 DOI: 10.1038/s41593-024-01600-y |
0.322 |
|
| 2024 |
De Strooper B, Karran E. New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The Embo Journal. PMID 38396302 DOI: 10.1038/s44318-024-00057-w |
0.34 |
|
| 2023 |
Hou P, Zielonka M, Serneels L, Martinez-Muriana A, Fattorelli N, Wolfs L, Poovathingal S, T'Syen D, Balusu S, Theys T, Fiers M, Mancuso R, Howden AJM, De Strooper B. The γ-secretase substrate proteome and its role in cell signaling regulation. Molecular Cell. 83: 4106-4122.e10. PMID 37977120 DOI: 10.1016/j.molcel.2023.10.029 |
0.334 |
|
| 2023 |
Aghaizu ND, Jolly S, Samra SK, Kalmar B, Craessaerts K, Greensmith L, Salinas PC, De Strooper B, Whiting PJ. Microglial Expression of the Wnt Signaling Modulator Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models. Eneuro. 10. PMID 36599670 DOI: 10.1523/ENEURO.0306-22.2022 |
0.364 |
|
| 2022 |
Moonen S, Koper MJ, Van Schoor E, Schaeverbeke JM, Vandenberghe R, von Arnim CAF, Tousseyn T, De Strooper B, Thal DR. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta Neuropathologica. 145: 175-195. PMID 36481964 DOI: 10.1007/s00401-022-02528-y |
0.355 |
|
| 2022 |
Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, ... ... de Strooper B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020 |
0.426 |
|
| 2022 |
Koper MJ, Tomé SO, Gawor K, Belet A, Van Schoor E, Schaeverbeke J, Vandenberghe R, Vandenbulcke M, Ghebremedhin E, Otto M, von Arnim CAF, Balusu S, Blaschko MB, De Strooper B, Thal DR. LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease. Acta Neuropathologica Communications. 10: 128. PMID 36057624 DOI: 10.1186/s40478-022-01432-6 |
0.329 |
|
| 2022 |
Karran E, De Strooper B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nature Reviews. Drug Discovery. PMID 35177833 DOI: 10.1038/s41573-022-00391-w |
0.336 |
|
| 2021 |
Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, Wong N, Stringer KM, Vitanova KS, Smith VC, Joshi D, Saito T, Saido TC, Hardy J, Hanrieder J, ... De Strooper B, et al. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular Neurodegeneration. 16: 47. PMID 34266459 DOI: 10.1186/s13024-021-00457-0 |
0.328 |
|
| 2021 |
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, et al. The App mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathologica Communications. 9: 6. PMID 33407903 DOI: 10.1186/s40478-020-01102-5 |
0.309 |
|
| 2020 |
Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, et al. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica. PMID 33319314 DOI: 10.1007/s00401-020-02249-0 |
0.355 |
|
| 2020 |
Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, ... ... De Strooper B, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. PMID 32702314 DOI: 10.1016/j.cell.2020.06.038 |
0.314 |
|
| 2020 |
Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/J.Neuron.2020.06.005 |
0.344 |
|
| 2020 |
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, et al. The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry. PMID 32223911 DOI: 10.1016/J.Biopsych.2020.02.001 |
0.394 |
|
| 2020 |
Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. Embo Molecular Medicine. e10606. PMID 31951107 DOI: 10.15252/Emmm.201910606 |
0.304 |
|
| 2020 |
Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y |
0.4 |
|
| 2019 |
Koper MJ, Van Schoor E, Ospitalieri S, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Tousseyn T, Balusu S, De Strooper B, Thal DR. Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease. Acta Neuropathologica. PMID 31802237 DOI: 10.1007/S00401-019-02103-Y |
0.34 |
|
| 2019 |
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, ... ... De Strooper B, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099 |
0.312 |
|
| 2018 |
Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B. Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice. Journal of Alzheimer's Disease : Jad. PMID 30320577 DOI: 10.3233/Jad-180410 |
0.318 |
|
| 2018 |
Shah D, Latif-Hernandez A, De Strooper B, Saito T, Saido T, Verhoye M, D'Hooge R, Van der Linden A. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP knock-in mice. Scientific Reports. 8: 6264. PMID 29674739 DOI: 10.1038/S41598-018-24657-9 |
0.314 |
|
| 2017 |
Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397 |
0.386 |
|
| 2017 |
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, ... De Strooper B, et al. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell. 170: 443-456.e14. PMID 28753424 DOI: 10.1016/J.Cell.2017.07.004 |
0.334 |
|
| 2017 |
Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B. Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. Embo Molecular Medicine. PMID 28588032 DOI: 10.15252/emmm.201707561 |
0.338 |
|
| 2017 |
Brownjohn PW, Smith J, Portelius E, Serneels L, Kvartsberg H, De Strooper B, Blennow K, Zetterberg H, Livesey FJ. Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. Stem Cell Reports. PMID 28285880 DOI: 10.1016/j.stemcr.2017.02.006 |
0.349 |
|
| 2017 |
Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, ... ... De Strooper B, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Molecular Neurodegeneration. 12: 25. PMID 28279219 DOI: 10.1186/S13024-017-0165-0 |
0.326 |
|
| 2017 |
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, ... ... De Strooper B, et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. PMID 28238547 DOI: 10.1016/J.Neuron.2017.02.001 |
0.695 |
|
| 2017 |
Timmers M, Barão S, Van Broeck B, Tesseur I, Slemmon J, De Waepenaert K, Bogert J, Shaw LM, Engelborghs S, Moechars D, Mercken M, Van Nueten L, Tritsmans L, de Strooper B, Streffer JR. BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants. Journal of Alzheimer's Disease : Jad. PMID 28157093 DOI: 10.3233/Jad-160829 |
0.7 |
|
| 2016 |
Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, ... ... De Strooper B, et al. De novo design of a biologically active amyloid. Science (New York, N.Y.). 354. PMID 27846578 DOI: 10.1126/Science.Aah4949 |
0.308 |
|
| 2016 |
Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, ... ... De Strooper B, et al. Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell. PMID 27293189 DOI: 10.1016/J.Cell.2016.05.020 |
0.355 |
|
| 2016 |
Karran E, De Strooper B. The amyloid cascade hypothesis: are we poised for success or failure? Journal of Neurochemistry. PMID 27255958 DOI: 10.1111/jnc.13632 |
0.324 |
|
| 2016 |
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer's disease. Lancet (London, England). PMID 26921134 DOI: 10.1016/S0140-6736(15)01124-1 |
0.313 |
|
| 2016 |
De Strooper B, Karran E. The Cellular Phase of Alzheimer's Disease. Cell. 164: 603-15. PMID 26871627 DOI: 10.1016/j.cell.2015.12.056 |
0.309 |
|
| 2016 |
Barão S, Moechars D, Lichtenthaler SF, De Strooper B. BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease. Trends in Neurosciences. PMID 26833257 DOI: 10.1016/j.tins.2016.01.003 |
0.35 |
|
| 2015 |
Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L. Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. The Journal of Experimental Medicine. PMID 26481686 DOI: 10.1084/Jem.20150892 |
0.328 |
|
| 2015 |
Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... De Strooper B, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/Scitranslmed.Aab3492 |
0.423 |
|
| 2015 |
Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, Van Hove I, Moons L, De Strooper B, Kanazir S, Libert C, Vandenbroucke RE. Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12766-78. PMID 26377465 DOI: 10.1523/JNEUROSCI.0006-15.2015 |
0.341 |
|
| 2014 |
Benilova I, Gallardo R, Ungureanu AA, Castillo Cano V, Snellinx A, Ramakers M, Bartic C, Rousseau F, Schymkowitz J, De Strooper B. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. The Journal of Biological Chemistry. 289: 30977-89. PMID 25253695 DOI: 10.1074/jbc.M114.599027 |
0.328 |
|
| 2014 |
Serneels L, Tesseur I, De Strooper B. Assay to probe proteolytic processing of Notch by γ-secretase. Methods in Molecular Biology (Clifton, N.J.). 1187: 223-9. PMID 25053493 DOI: 10.1007/978-1-4939-1139-4_17 |
0.644 |
|
| 2014 |
Pimenova AA, Thathiah A, De Strooper B, Tesseur I. Regulation of amyloid precursor protein processing by serotonin signaling. Plos One. 9: e87014. PMID 24466315 DOI: 10.1371/Journal.Pone.0087014 |
0.706 |
|
| 2013 |
Tesseur I, De Strooper B. When the dust settles: what did we learn from the bexarotene discussion? Alzheimer's Research & Therapy. 5: 54. PMID 24229456 DOI: 10.1186/Alzrt218 |
0.689 |
|
| 2013 |
Benilova I, De Strooper B. Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner. Science (New York, N.Y.). 341: 1354-5. PMID 24052299 DOI: 10.1126/science.1244166 |
0.312 |
|
| 2013 |
Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R. Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500. Neuropharmacology. 75: 458-66. PMID 24035915 DOI: 10.1016/J.Neuropharm.2013.08.030 |
0.673 |
|
| 2013 |
Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D'Hooge R. Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 109-25. PMID 23788007 DOI: 10.3233/Jad-122296 |
0.702 |
|
| 2013 |
Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G. BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 10658-63. PMID 23754390 DOI: 10.1073/pnas.1220748110 |
0.374 |
|
| 2013 |
Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D'Hooge R, De Strooper B. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-e. PMID 23704554 DOI: 10.1126/science.1233937 |
0.691 |
|
| 2013 |
Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Current Alzheimer Research. 10: 671-8. PMID 23566348 DOI: 10.2174/15672050113109990138 |
0.518 |
|
| 2013 |
Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B. Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiology of Aging. 34: 1779-89. PMID 23474291 DOI: 10.1016/J.Neurobiolaging.2013.01.020 |
0.675 |
|
| 2013 |
Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B. β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. Nature Medicine. 19: 43-9. PMID 23202293 DOI: 10.1038/nm.3023 |
0.351 |
|
| 2013 |
Tesseur I, Lo A, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D’Hooge R, De Strooper B. Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs Molecular Neurodegeneration. 8: P40. DOI: 10.1186/1750-1326-8-S1-P40 |
0.685 |
|
| 2012 |
Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, ... ... De Strooper B, et al. Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Molecular Neurodegeneration. 7: 61. PMID 23249765 DOI: 10.1186/1750-1326-7-61 |
0.348 |
|
| 2012 |
Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, ... ... De Strooper B, et al. Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17297-305. PMID 23197721 DOI: 10.1523/Jneurosci.1451-12.2012 |
0.327 |
|
| 2012 |
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. Embo Molecular Medicine. 4: 660-73. PMID 22488900 DOI: 10.1002/Emmm.201200243 |
0.345 |
|
| 2012 |
De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine. 2: a006304. PMID 22315713 DOI: 10.1101/cshperspect.a006304 |
0.35 |
|
| 2012 |
Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. The Journal of Biological Chemistry. 287: 1100-11. PMID 22086926 DOI: 10.1074/Jbc.M111.288258 |
0.326 |
|
| 2011 |
Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/Jbc.M111.280495 |
0.684 |
|
| 2011 |
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proceedings of the National Academy of Sciences of the United States of America. 108: E559-68. PMID 21825135 DOI: 10.1073/Pnas.1100745108 |
0.336 |
|
| 2011 |
Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. Journal of Neurochemistry. 119: 231-9. PMID 21812781 DOI: 10.1111/j.1471-4159.2011.07412.x |
0.334 |
|
| 2011 |
Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of Disease. 44: 284-91. PMID 21807097 DOI: 10.1016/J.Nbd.2011.07.006 |
0.521 |
|
| 2011 |
Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. Embo Molecular Medicine. 3: 291-302. PMID 21500352 DOI: 10.1002/Emmm.201100138 |
0.51 |
|
| 2011 |
Thathiah A, De Strooper B. The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nature Reviews. Neuroscience. 12: 73-87. PMID 21248787 DOI: 10.1038/nrn2977 |
0.366 |
|
| 2010 |
Benilova I, De Strooper B. Prion protein in Alzheimer's pathogenesis: a hot and controversial issue. Embo Molecular Medicine. 2: 289-90. PMID 20698011 DOI: 10.1002/emmm.201000088 |
0.321 |
|
| 2010 |
De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiological Reviews. 90: 465-94. PMID 20393191 DOI: 10.1152/physrev.00023.2009 |
0.355 |
|
| 2010 |
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, et al. The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4833-44. PMID 20371803 DOI: 10.1523/Jneurosci.5221-09.2010 |
0.675 |
|
| 2010 |
De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218 |
0.368 |
|
| 2010 |
Bergmans BA, De Strooper B. gamma-secretases: from cell biology to therapeutic strategies. The Lancet. Neurology. 9: 215-26. PMID 20129170 DOI: 10.1016/S1474-4422(09)70332-1 |
0.324 |
|
| 2010 |
Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B. Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation. Stem Cells (Dayton, Ohio). 28: 399-406. PMID 20049903 DOI: 10.1002/Stem.296 |
0.304 |
|
| 2009 |
Thathiah A, De Strooper B. G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. Science Signaling. 2: re8. PMID 19843960 DOI: 10.1126/scisignal.293re8 |
0.37 |
|
| 2009 |
Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà -Freixa J, Suzuki T, Fernà ndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a Journal of Neurology. 132: 1335-45. PMID 19251756 DOI: 10.1093/Brain/Awp023 |
0.384 |
|
| 2009 |
Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (New York, N.Y.). 323: 946-51. PMID 19213921 DOI: 10.1126/Science.1160649 |
0.362 |
|
| 2008 |
O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047 |
0.337 |
|
| 2008 |
Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/Jneurosci.2635-08.2008 |
0.513 |
|
| 2008 |
Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F. Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. The Embo Journal. 27: 224-33. PMID 18059472 DOI: 10.1038/Sj.Emboj.7601953 |
0.322 |
|
| 2007 |
Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. The Journal of Pharmacology and Experimental Therapeutics. 323: 822-30. PMID 17895400 DOI: 10.1124/jpet.107.129007 |
0.351 |
|
| 2006 |
Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S, Bormans G, Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De Strooper B, Van Broeckhoven C, Vandenberghe R. Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment. Human Mutation. 27: 888-96. PMID 16917905 DOI: 10.1002/Humu.20402 |
0.305 |
|
| 2006 |
Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, Müller U, De Strooper B. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. Embo Reports. 7: 739-45. PMID 16729020 DOI: 10.1038/sj.embor.7400704 |
0.31 |
|
| 2005 |
Reinhard C, Hébert SS, De Strooper B. The amyloid-beta precursor protein: integrating structure with biological function. The Embo Journal. 24: 3996-4006. PMID 16252002 DOI: 10.1038/sj.emboj.7600860 |
0.322 |
|
| 2005 |
Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, Tschäpe JA, De Strooper B, Müller U, Shen J, Hartmann T. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nature Cell Biology. 7: 1118-23. PMID 16227967 DOI: 10.1038/Ncb1313 |
0.33 |
|
| 2005 |
Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, ... ... De Strooper B, et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. The Journal of Biological Chemistry. 280: 30797-806. PMID 15987683 DOI: 10.1074/Jbc.M505249200 |
0.326 |
|
| 2005 |
Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. The Journal of Biological Chemistry. 280: 23009-17. PMID 15824102 DOI: 10.1074/Jbc.M414648200 |
0.316 |
|
| 2005 |
Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 1719-24. PMID 15665098 DOI: 10.1073/Pnas.0408901102 |
0.313 |
|
| 2004 |
Dominguez DI, Hartmann D, De Strooper B. BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease. Neuro-Degenerative Diseases. 1: 168-74. PMID 16908986 DOI: 10.1159/000080982 |
0.34 |
|
| 2004 |
Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG. Neuronal membrane cholesterol loss enhances amyloid peptide generation. The Journal of Cell Biology. 167: 953-60. PMID 15583033 DOI: 10.1083/Jcb.200404149 |
0.313 |
|
| 2004 |
Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B. Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10908-17. PMID 15574741 DOI: 10.1523/JNEUROSCI.3987-04.2004 |
0.321 |
|
| 2003 |
De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron. 38: 9-12. PMID 12691659 DOI: 10.1016/S0896-6273(03)00205-8 |
0.333 |
|
| 2002 |
Kumar-Singh S, Julliams A, Nuydens R, Ceuterick C, Labeur C, Serneels S, Vennekens K, Van Osta P, Geerts H, De Strooper B, Van Broeckhoven C. In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity. Neurobiology of Disease. 11: 330-40. PMID 12505425 DOI: 10.1006/nbdi.2002.0529 |
0.321 |
|
| 2002 |
Annaert W, De Strooper B. A cell biological perspective on Alzheimer's disease. Annual Review of Cell and Developmental Biology. 18: 25-51. PMID 12142279 DOI: 10.1146/annurev.cellbio.18.020402.142302 |
0.363 |
|
| 2002 |
Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. The Journal of Biological Chemistry. 277: 12915-20. PMID 11799129 DOI: 10.1074/Jbc.M112372200 |
0.352 |
|
| 2001 |
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. Journal of Neurochemistry. 78: 1168-78. PMID 11553691 |
0.347 |
|
| 2001 |
Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. The Journal of Biological Chemistry. 276: 42645-57. PMID 11526104 DOI: 10.1074/Jbc.M102790200 |
0.33 |
|
| 2001 |
De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. Human Molecular Genetics. 10: 1665-71. PMID 11487570 DOI: 10.1093/Hmg/10.16.1665 |
0.312 |
|
| 2001 |
Dominguez DI, De Strooper B, Annaert W. Secretases as therapeutic targets for the treatment of Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 124-42. PMID 11409035 DOI: 10.3109/13506120109007356 |
0.339 |
|
| 2001 |
Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. Processing of beta-secretase by furin and other members of the proprotein convertase family. The Journal of Biological Chemistry. 276: 4211-7. PMID 11071887 DOI: 10.1074/Jbc.M006947200 |
0.341 |
|
| 2000 |
Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG. Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. Embo Reports. 1: 530-5. PMID 11263499 DOI: 10.1093/Embo-Reports/Kvd107 |
0.38 |
|
| 2000 |
Annaert W, Cupers P, Saftig P, De Strooper B. Presenilin function in APP processing. Annals of the New York Academy of Sciences. 920: 158-64. PMID 11193144 DOI: 10.1111/J.1749-6632.2000.Tb06917.X |
0.379 |
|
| 2000 |
Annaert W, De Strooper B. Neuronal models to study amyloid precursor protein expression and processing in vitro. Biochimica Et Biophysica Acta. 1502: 53-62. PMID 10899431 DOI: 10.1016/S0925-4439(00)00032-6 |
0.388 |
|
| 2000 |
De Strooper B, Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. Journal of Cell Science. 113: 1857-70. PMID 10806097 |
0.341 |
|
| 1999 |
Saftig P, Hartmann D, De Strooper B. The function of presenilin-1 in amyloid beta-peptide generation and brain development. European Archives of Psychiatry and Clinical Neuroscience. 249: 271-9. PMID 10653282 DOI: 10.1007/S004060050099 |
0.347 |
|
| 1999 |
Haass C, De Strooper B. The presenilins in Alzheimer's disease--proteolysis holds the key. Science (New York, N.Y.). 286: 916-9. PMID 10542139 DOI: 10.1126/Science.286.5441.916 |
0.41 |
|
| 1999 |
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. The Journal of Cell Biology. 147: 277-94. PMID 10525535 DOI: 10.1083/Jcb.147.2.277 |
0.322 |
|
| 1999 |
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, ... ... De Strooper B, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/Pnas.96.21.11872 |
0.505 |
|
| 1999 |
Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981 |
0.532 |
|
| 1998 |
Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F. Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research. 95: 55-64. PMID 9754877 DOI: 10.1016/S0166-4328(97)00210-6 |
0.553 |
|
| 1998 |
Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 6460-4. PMID 9600988 DOI: 10.1073/Pnas.95.11.6460 |
0.332 |
|
| 1998 |
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910 |
0.576 |
|
| 1997 |
De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/Jbc.272.6.3590 |
0.525 |
|
| 1996 |
Tienari PJ, De Strooper B, Ikonen E, Ida N, Simons M, Masters CL, Dotti CG, Beyreuther K. Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 575-85. PMID 9246484 DOI: 10.1101/Sqb.1996.061.01.058 |
0.325 |
|
| 1996 |
De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S, Carmeliet G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. Dermatology (Basel, Switzerland). 193: 212-20. PMID 8944343 |
0.467 |
|
| 1996 |
Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. The Journal of Biological Chemistry. 271: 27241-4. PMID 8910296 DOI: 10.1074/jbc.271.44.27241 |
0.575 |
|
| 1996 |
Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567 |
0.497 |
|
| 1996 |
Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The Embo Journal. 15: 1265-74. PMID 8635459 |
0.532 |
|
| 1995 |
De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 30310-4. PMID 8530453 |
0.532 |
|
| 1995 |
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. The Journal of Biological Chemistry. 270: 4058-65. PMID 7876155 |
0.56 |
|
| 1995 |
De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven WJ, Van Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochimica Et Biophysica Acta. 1246: 185-8. PMID 7819286 |
0.535 |
|
| 1995 |
Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Genomics. 25: 492-500. PMID 7789983 |
0.434 |
|
| 1995 |
Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. Dementia (Basel, Switzerland). 6: 63-8. PMID 7606281 |
0.577 |
|
| 1995 |
De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622 DOI: 10.1002/J.1460-2075.1995.Tb00176.X |
0.588 |
|
| 1995 |
Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65: 1009-25. PMID 7542371 |
0.518 |
|
| 1994 |
Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B. Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24: 78-89. PMID 7534747 |
0.452 |
|
| 1994 |
Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. Genomics. 22: 519-29. PMID 7528166 DOI: 10.1006/geno.1994.1425 |
0.426 |
|
| 1993 |
Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S. Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochimica Et Biophysica Acta. 1173: 71-4. PMID 8485155 |
0.459 |
|
| 1993 |
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway. The Journal of Cell Biology. 121: 295-304. PMID 8468348 |
0.572 |
|
| 1993 |
Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiology of Aging. 14: 233-7. PMID 7686641 |
0.521 |
|
| 1993 |
De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. Immunology Today. 14: 143-4. PMID 7682079 |
0.469 |
|
| 1993 |
Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B, Deckmyn H, Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. Hybridoma. 12: 467-74. PMID 7503943 |
0.437 |
|
| 1992 |
Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F, Tarcsay L, Cerletti N, Odink K, Diehl V, Bilbe G. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Blood. 80: 2891-6. PMID 1450414 |
0.46 |
|
| 1992 |
De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. Febs Letters. 308: 50-3. PMID 1379551 |
0.539 |
|
| 1992 |
van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H. The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. European Journal of Biochemistry / Febs. 210: 319-27. PMID 1280217 |
0.442 |
|
| 1991 |
De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman JJ. Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. European Journal of Biochemistry / Febs. 199: 25-33. PMID 1906002 |
0.468 |
|
| 1991 |
De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochimica Et Biophysica Acta. 1129: 141-3. PMID 1756177 |
0.519 |
|
| 1989 |
De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1 subgroup of the integrins in human cells and tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 299-307. PMID 2645360 |
0.445 |
|
| 1988 |
De Strooper B, Saison M, Jaspers M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. Cell Biology International Reports. 12: 9-16. PMID 2969294 |
0.469 |
|
| 1988 |
Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den Berghe H, Cassiman JJ. Post-translational modification of the beta-subunit of the human fibronectin receptor. Febs Letters. 231: 402-6. PMID 2966078 DOI: 10.1016/0014-5793(88)80859-7 |
0.473 |
|
| 1988 |
Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ. Mapping of human fibronectin receptor beta subunit gene to chromosome 10. Somatic Cell and Molecular Genetics. 14: 99-104. PMID 2963381 |
0.463 |
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