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Erik J. Sontheimer, Ph.D. - Publications

Affiliations: 
1999-2014 Molecular Biosciences Northwestern University, Evanston, IL 
 2014- RNA Therapeutics Institute University Of Massachusetts Med Sch Worcester 
Area:
RNA biology, CRISPR, genome editing
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kraus C, Sontheimer EJ. Viruses use RNA decoys to thwart CRISPR defences. Nature. 623: 490-491. PMID 37853195 DOI: 10.1038/d41586-023-03133-z  0.376
2022 Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ. A split prime editor with untethered reverse transcriptase and circular RNA template. Nature Biotechnology. PMID 35379962 DOI: 10.1038/s41587-022-01255-9  0.367
2020 Barrangou R, Sontheimer EJ. Shutting down RNA-targeting CRISPR. Science (New York, N.Y.). 369: 31-32. PMID 32631881 DOI: 10.1126/science.abc8243  0.5
2019 Gao XD, Rodríguez TC, Sontheimer EJ. Adapting dCas9-APEX2 for subnuclear proteomic profiling. Methods in Enzymology. 616: 365-383. PMID 30691651 DOI: 10.1016/bs.mie.2018.10.030  0.328
2018 Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641. PMID 29980686 DOI: 10.1038/S41467-018-05073-Z  0.507
2016 Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science (New York, N.Y.). 351: 920-1. PMID 26917756 DOI: 10.1126/Science.Aaf2851  0.654
2015 Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ. DNase H Activity of Neisseria meningitidis Cas9. Molecular Cell. 60: 242-55. PMID 26474066 DOI: 10.1016/j.molcel.2015.09.020  0.502
2015 Wakefield N, Rajan R, Sontheimer EJ. Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. Febs Letters. 589: 3197-204. PMID 26364721 DOI: 10.1016/j.febslet.2015.09.005  0.711
2015 Sontheimer EJ, Barrangou R. The Bacterial Origins of the CRISPR Genome-Editing Revolution. Human Gene Therapy. 26: 413-24. PMID 26078042 DOI: 10.1089/hum.2015.091  0.337
2013 Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proceedings of the National Academy of Sciences of the United States of America. 110: 15644-9. PMID 23940360 DOI: 10.1073/Pnas.1313587110  0.514
2013 Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ. Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis. Molecular Cell. 50: 488-503. PMID 23706818 DOI: 10.1016/J.Molcel.2013.05.001  0.537
2013 Kim Guisbert KS, Sontheimer EJ. Quit stalling or you'll be silenced. Cell. 152: 938-9. PMID 23452843 DOI: 10.1016/j.cell.2013.02.025  0.489
2012 Sontheimer EJ. Small RNAs of opposite sign… but same absolute value. Cell. 151: 1157-8. PMID 23217700 DOI: 10.1016/j.cell.2012.11.032  0.44
2011 Gerbasi VR, Preall JB, Golden DE, Powell DW, Cummins TD, Sontheimer EJ. Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 3204-9. PMID 21300896 DOI: 10.1073/Pnas.1009781108  0.526
2010 Sontheimer EJ, Marraffini LA. Microbiology: slicer for DNA. Nature. 468: 45-6. PMID 21048757 DOI: 10.1038/468045A  0.663
2010 Gerbasi VR, Golden DE, Hurtado SB, Sontheimer EJ. Proteomics identification of Drosophila small interfering RNA-associated factors. Molecular & Cellular Proteomics : McP. 9: 1866-72. PMID 20472918 DOI: 10.1074/Mcp.M900614-Mcp200  0.535
2010 Marraffini LA, Sontheimer EJ. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nature Reviews. Genetics. 11: 181-90. PMID 20125085 DOI: 10.1038/Nrg2749  0.717
2010 Marraffini LA, Sontheimer EJ. Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature. 463: 568-71. PMID 20072129 DOI: 10.1038/Nature08703  0.649
2009 Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim do H, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW. Silencing by small RNAs is linked to endosomal trafficking. Nature Cell Biology. 11: 1150-6. PMID 19684574 DOI: 10.1038/Ncb1930  0.823
2009 Marraffini LA, Sontheimer EJ. Invasive DNA, chopped and in the CRISPR. Structure (London, England : 1993). 17: 786-8. PMID 19523896 DOI: 10.1016/J.Str.2009.05.002  0.606
2009 Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 136: 642-55. PMID 19239886 DOI: 10.1016/j.cell.2009.01.035  0.368
2008 Marraffini LA, Sontheimer EJ. CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science (New York, N.Y.). 322: 1843-5. PMID 19095942 DOI: 10.1126/Science.1165771  0.627
2008 Bellare P, Small EC, Huang X, Wohlschlegel JA, Staley JP, Sontheimer EJ. A role for ubiquitin in the spliceosome assembly pathway. Nature Structural & Molecular Biology. 15: 444-51. PMID 18425143 DOI: 10.1038/Nsmb.1401  0.778
2007 Bellare P, Sontheimer EJ. A fork in the road for microRNAs. Nature Structural & Molecular Biology. 14: 684-6. PMID 17676029 DOI: 10.1038/nsmb0807-684  0.743
2006 Preall JB, He Z, Gorra JM, Sontheimer EJ. Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila. Current Biology : Cb. 16: 530-5. PMID 16527750 DOI: 10.1016/j.cub.2006.01.061  0.813
2006 Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. Rna (New York, N.Y.). 12: 292-302. PMID 16428608 DOI: 10.1261/Rna.2152306  0.775
2005 Preall JB, Sontheimer EJ. RNAi: RISC gets loaded. Cell. 123: 543-5. PMID 16286001 DOI: 10.1016/j.cell.2005.11.006  0.352
2005 Pham JW, Sontheimer EJ. Molecular requirements for RNA-induced silencing complex assembly in the Drosophila RNA interference pathway. The Journal of Biological Chemistry. 280: 39278-83. PMID 16179342 DOI: 10.1074/jbc.M509202200  0.721
2005 Pellino JL, Jaskiewicz L, Filipowicz W, Sontheimer EJ. ATP modulates siRNA interactions with an endogenous human Dicer complex. Rna (New York, N.Y.). 11: 1719-24. PMID 16177131 DOI: 10.1261/rna.2102805  0.758
2005 Sontheimer EJ, Carthew RW. Silence from within: endogenous siRNAs and miRNAs. Cell. 122: 9-12. PMID 16009127 DOI: 10.1016/j.cell.2005.06.030  0.356
2005 Pham JW, Sontheimer EJ. Separation of Drosophila RNA silencing complexes by native gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 309: 11-6. PMID 15990394 DOI: 10.1385/1-59259-935-4:011  0.719
2005 Sontheimer EJ. Assembly and function of RNA silencing complexes. Nature Reviews. Molecular Cell Biology. 6: 127-38. PMID 15654322 DOI: 10.1038/nrm1568  0.555
2004 He Z, Sontheimer EJ. "siRNAs and miRNAs": a meeting report on RNA silencing. Rna (New York, N.Y.). 10: 1165-73. PMID 15272116 DOI: 10.1261/rna.7900204  0.796
2004 Pham JW, Sontheimer EJ. The Making of an siRNA. Molecular Cell. 15: 163-4. PMID 15260964 DOI: 10.1016/j.molcel.2004.07.002  0.598
2004 Pham JW, Radhakrishnan I, Sontheimer EJ. Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Research. 32: 3446-55. PMID 15247335 DOI: 10.1093/Nar/Gkh658  0.738
2004 Pham JW, Pellino JL, Lee YS, Carthew RW, Sontheimer EJ. A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell. 117: 83-94. PMID 15066284 DOI: 10.1016/S0092-8674(04)00258-2  0.747
2004 Lee YS, Nakahara K, Pham JW, Kim K, He Z, Sontheimer EJ, Carthew RW. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell. 117: 69-81. PMID 15066283 DOI: 10.1016/S0092-8674(04)00261-2  0.787
2003 Pellino JL, Sontheimer EJ. R2D2 leads the silencing trigger to mRNA's death star. Cell. 115: 132-3. PMID 14567910 DOI: 10.1016/S0092-8674(03)00806-7  0.788
2001 Sontheimer EJ. The spliceosome shows its metal Nature Structural Biology. 8: 11-13. PMID 11135658 DOI: 10.1038/82979  0.385
2000 Gordon PM, Sontheimer EJ, Piccirilli JA. Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis. Biochemistry. 39: 12939-52. PMID 11041859 DOI: 10.1021/Bi001089O  0.551
2000 Gordon PM, Sontheimer EJ, Piccirilli JA. Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns. Rna (New York, N.Y.). 6: 199-205. PMID 10688359 DOI: 10.1017/S1355838200992069  0.619
2000 Warnecke JM, Sontheimer EJ, Piccirilli JA, Hartmann RK. Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage. Nucleic Acids Research. 28: 720-7. PMID 10637323 DOI: 10.1093/Nar/28.3.720  0.586
1999 Sontheimer EJ, Gordon PM, Piccirilli JA. Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome. Genes & Development. 13: 1729-41. PMID 10398685 DOI: 10.1101/Gad.13.13.1729  0.587
1999 Sontheimer EJ. Bridging sulfur substitutions in the analysis of Pre-mRNA splicing Methods: a Companion to Methods in Enzymology. 18: 29-37. PMID 10208814 DOI: 10.1006/meth.1999.0754  0.428
1997 Sontheimer EJ, Sun S, Piccirilli JA. Metal ion catalysis during splicing of premessenger RNA. Nature. 388: 801-5. PMID 9285595 DOI: 10.1038/42068  0.615
1994 Sontheimer EJ. Site-specific RNA crosslinking with 4-thiouridine Molecular Biology Reports. 20: 35-44. PMID 7531281 DOI: 10.1007/BF00999853  0.47
1993 Sontheimer EJ, Steitz JA. The U5 and U6 small nuclear RNAs as active site components of the spliceosome Science. 262: 1989-1996. PMID 8266094 DOI: 10.1126/Science.8266094  0.665
1993 Cortes JJ, Sontheimer EJ, Seiwert SD, Steitz JA. Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5' splice sites in vivo. The Embo Journal. 12: 5181-9. PMID 8262061 DOI: 10.1002/J.1460-2075.1993.Tb06213.X  0.546
1992 Gelpi C, Sontheimer EJ, Rodriguez-Sanchez JL. Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proceedings of the National Academy of Sciences of the United States of America. 89: 9739-43. PMID 1409691  0.35
1992 Wyatt JR, Sontheimer EJ, Steitz JA. Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing Genes and Development. 6: 2542-2553. PMID 1340469 DOI: 10.1101/Gad.6.12B.2542  0.588
1992 Sontheimer EJ, Steitz JA. Three novel functional variants of human U5 small nuclear RNA Molecular and Cellular Biology. 12: 734-746. PMID 1310151 DOI: 10.1128/Mcb.12.2.734  0.62
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